glide2, glial cells missing 2
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gcm2 using the Feature Mapper tool.
In the larval visual system, gcm2 transcript is expressed not only in specific glial subtypes, but also in the lineage that gives rise to lamina neurons.
gcm2 expression is observed in the larval optic lobe in some glial subtypes and in a lineage that gives rise to lamina neurons. Expression begins in glial precursor cells at the lamina margins that will give rise to epithelial and marginal glial cells. Expression is also observed in neruonal precursors in the lamina.
GBrowse - Visual display of RNA-Seq signalsView Dmel\gcm2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of gcm2 causes an increase in lateral branching and a marked reduction in dorsal extension of ddaE neurons. RNAi also causes defects in dendrite morphogenesis.
gcm2 is sufficient to induce gliogenesis within and outside the nervous system.