Gene: Dmel\colt
CACT
Please see the JBrowse view of Dmel\colt for information on other features
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Multiple additional alternative polyA sites documented in FBrf0099765.
Gene model reviewed during 5.47
1.4 (northern blot)
306 (aa); 33 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\colt using the Feature Mapper tool.
colt transcript is detected in all developmental stages, but is most abundant in adults.
GBrowse - Visual display of RNA-Seq signals
View Dmel\colt in GBrowse 22-7
2-6.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
The product of colt is presumed to be involved in a mitochondrial metabolic process and can be critically required in specific morphogenetic mechanisms.
Embryonic development can take place without zygotic colt function giving rise to larvae with incomplete filling of the tracheal system with gas. If development proceeds further colt function specifically affects morphogenesis of the wings, by altering the differentiation of the wing epithelial cells and by blocking the unfolding and expansion of the wings after eclosion.
