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Gene Dmel\Smg5

General Information
Symbol	Dmel\Smg5	Species	D. melanogaster
Name	Smg5	Annotation symbol	CG8954
Feature type	protein_coding_gene	FlyBase ID	FBgn0019890
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	BG:DS08220.2
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34E2-34E2	Sequence location	2L:13,899,353..13,904,659 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Smg5 is referred to in FlyBase by the symbol Dmel\Smg5 (CG8954, FBgn0019890). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. 15 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA/RNA-binding domain, Est1-type; Nucleotide binding protein, PINc; Telomerase activating protein Est1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627564_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Smg5. Gene sequence location is 2L:13899353..13904659.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34E2-34E2   Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34E2-34E3   (determined by in situ hybridisation)   (Ashburner et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Smg5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD22235 appears problematic: incomplete CDS DGC clone LD42783 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Smg5-RA FBtr0080561  NM_135841   4276   1177 Smg5-RB FBtr0080562  NM_165069   4167   1177
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Smg5-PA   FBpp0080138   135.3   1177   7.46     NP_609685   AAF53351 Smg5-PB   FBpp0080139   135.3   1177   7.46     NP_723851   AAF53352
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA/RNA-binding domain, Est1-type (IPR018834) Nucleotide binding protein, PINc (IPR006596) Telomerase activating protein Est1 (IPR019458) PIN domain (IPR002716)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202382   AA246968   AA540559   AA816812   AA820087   AA952054   AE014134 AAF53351   AE014134 AAF53352   AE003408 AAF44833   AI106599   AI113575   AI114061   AI516747   AI542236   AJ556817 CAD89222   AQ073365   AW942629   AW943626   AY058705 AAL13934   AY069495 AAL39640   BF487249   BF496026   BF497326   BF498736   BG633857   BG637854   BG638296   BG641389   BH634792   BI361462   BI577504   BI578780   BP542063   BT031137   CO272224   CO277023   CO277259   CO289269   CO300146   CO308300   CO310093   CO312464   CO316169   CO332328   CO343039   CO343398   CZ466529   CZ469119   CZ470095   CZ477997   CZ481753   CZ481978   EC070216   EC071825   EC088275   EC200198   EC203751   EC205267   EC220557   EC220611   EC225073   EC225245   EC250513   EC254898   EC254940   EC260584   ES696018   GH941605   GH941619   GH943368   GH944032   GH944203   GH944828   GH945664   GH946590   GH948152   GH948433   GH948537   GH949056   GH950691   GH951112   GH951290   GH951433   GH951483   GH952343   GH952891   GH954047   GH954249   GH954539   GH955259   GH956052   GH956261   GH956537   GH957099   GH958359   GH958893   GH959050   GH960266   GH960273   GH960883   GH961559   GH962778   GH964391   GH964615   GH964894   GH966385   GH967059   GH967544   GH967774   GH968144   GH968312   GH968315   GH968636   GH969172   GH969682   GH970823   GH971046   GH973028   GH973633   GH973693   GH973925   GH974273   GH974824   GH974891   GH975115   GH975165   GH975338   GH975981   GH976985   GH977045   GH977274   GH979021   GH982098   GH983549   GH983557   GH983952   GH985000   L80114
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V414 Q8T080 Q95TL1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal ectoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain    612.1 Adult Thoracic-Abdominal Ganglion    516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain  (612.1) Adult Thoracic-Abdominal Ganglion  516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain    612.1 Adult Thoracic-Abdominal Ganglion    516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain    612.1 Adult Thoracic-Abdominal Ganglion    516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain    612.1 Adult Thoracic-Abdominal Ganglion    516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain  612.1 Adult Thoracic-Abdominal Ganglion  516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain    612.1 Adult Thoracic-Abdominal Ganglion    516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    304.05 Larval Midgut    156.5 Larval Hindgut    154.6 Larval Malpighian Tubules    354.6 Larval Fat Body    203.4 Larval Salivary Gland    362.2 Larval Trachea    249.8 Larval Carcass    221.225 Adult Head    211.7 Adult Eye    343.85 Adult Brain    612.1 Adult Thoracic-Abdominal Ganglion    516.1 Adult Crop    193.3 Adult Midgut    136 Adult Hindgut    167.3 Adult Malpighian Tubules    268.6 Adult Fat Body    213.7 Adult Salivary Gland    273.7 Adult Heart    296.025 Adult VirginFemale Spermatheca    261.6 Adult InseminatedFemale Spermatheca    260.4 Adult Ovary    138.4 Adult Testis    261.6 Adult Male Accessory Gland    213.5 Adult Carcass    221.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    211.7   NA  Eye    343.85   NA  Brain    612.1   304.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    516.1   NA  Crop    193.3   156.5  Midgut    136   154.6  Hindgut    167.3   354.6  Malpighian Tubules    268.6   203.4  Fat Body    213.7   362.2  Salivary Gland    273.7   NA  Heart    296.025   249.8  Trachea    NA   NA  VirginFemale Spermatheca    261.6   NA  InseminatedFemale Spermatheca    260.4   NA  Ovary    138.4   NA  Testis    261.6   NA  Male Accessory Gland    213.5   221.225  Carcass    221.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    39 central nervous system, pupae P8    32 head, virgin 1-day female    24 head, virgin 4-day female    27 head, virgin 20-day female    26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male    40 head, mated 4-day male    36 head, mated 20-day male    41 salivary gland, larvae L3 wandering    74 salivary gland, white prepupae    294 digestive system, larvae L3 wandering    72 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae    35 fat body, pupae P8    26 carcass, larvae L3 wandering    56 carcass, 1-day adult    27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (39) central nervous system, pupae P8  (32) head, virgin 1-day female    24 head, virgin 4-day female  (27) head, virgin 20-day female  26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male  (40) head, mated 4-day male  (36) head, mated 20-day male  (41) salivary gland, larvae L3 wandering  (74) salivary gland, white prepupae  (294) digestive system, larvae L3 wandering  (72) digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae  (35) fat body, pupae P8  26 carcass, larvae L3 wandering  (56) carcass, 1-day adult  (27) carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male  26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    39 central nervous system, pupae P8    32 head, virgin 1-day female    24 head, virgin 4-day female    27 head, virgin 20-day female    26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male    40 head, mated 4-day male    36 head, mated 20-day male    41 salivary gland, larvae L3 wandering    74 salivary gland, white prepupae  (294) digestive system, larvae L3 wandering    72 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae    35 fat body, pupae P8    26 carcass, larvae L3 wandering    56 carcass, 1-day adult    27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    39 central nervous system, pupae P8    32 head, virgin 1-day female    24 head, virgin 4-day female    27 head, virgin 20-day female    26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male    40 head, mated 4-day male    36 head, mated 20-day male    41 salivary gland, larvae L3 wandering    74 salivary gland, white prepupae    294 digestive system, larvae L3 wandering    72 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae    35 fat body, pupae P8    26 carcass, larvae L3 wandering    56 carcass, 1-day adult    27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    26 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    39 central nervous system, pupae P8    32 head, virgin 1-day female    24 head, virgin 4-day female    27 head, virgin 20-day female    26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male    40 head, mated 4-day male    36 head, mated 20-day male    41 salivary gland, larvae L3 wandering    74 salivary gland, white prepupae    294 digestive system, larvae L3 wandering    72 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae    35 fat body, pupae P8    26 carcass, larvae L3 wandering    56 carcass, 1-day adult    27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (39) central nervous system, pupae P8  32 head, virgin 1-day female    24 head, virgin 4-day female  27 head, virgin 20-day female  26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male  (40) head, mated 4-day male  (36) head, mated 20-day male  (41) salivary gland, larvae L3 wandering  (74) salivary gland, white prepupae  (294) digestive system, larvae L3 wandering  (72) digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae  (35) fat body, pupae P8  26 carcass, larvae L3 wandering  (56) carcass, 1-day adult  27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male  26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    39 central nervous system, pupae P8    32 head, virgin 1-day female    24 head, virgin 4-day female    27 head, virgin 20-day female    26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male    40 head, mated 4-day male    36 head, mated 20-day male    41 salivary gland, larvae L3 wandering    74 salivary gland, white prepupae  (294) digestive system, larvae L3 wandering    72 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae    35 fat body, pupae P8    26 carcass, larvae L3 wandering    56 carcass, 1-day adult    27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    39 central nervous system, pupae P8    32 head, virgin 1-day female    24 head, virgin 4-day female    27 head, virgin 20-day female    26 head, mated 1-day female    24 head, mated 4-day female    22 head, mated 20-day female    22 head, mated 1-day male    40 head, mated 4-day male    36 head, mated 20-day male    41 salivary gland, larvae L3 wandering    74 salivary gland, white prepupae    294 digestive system, larvae L3 wandering    72 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    17 fat body, larvae L3 wandering    23 fat body, white prepupae    35 fat body, pupae P8    26 carcass, larvae L3 wandering    56 carcass, 1-day adult    27 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    26 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    60 embryo 04-06hr    62 embryo 06-08hr    40 embryo 08-10hr    35 embryo 10-12hr    25 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    33 embryo 18-20hr    38 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    60 white prepupae new    69 white prepupae 12hr    60 white prepupae 24hr    53 pupae 2d postWPP    45 pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day    30 adult male 05day    34 adult male 30day    29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr  (60) embryo 04-06hr  (62) embryo 06-08hr  (40) embryo 08-10hr  (35) embryo 10-12hr    25 embryo 12-14hr  26 embryo 14-16hr  (28) embryo 16-18hr  (33) embryo 18-20hr  (38) embryo 20-22hr  (34) embryo 22-24hr  (39) larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9  (60) white prepupae new  (69) white prepupae 12hr  (60) white prepupae 24hr  (53) pupae 2d postWPP  (45) pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day  (30) adult male 05day  (34) adult male 30day  (29) adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    60 embryo 04-06hr    62 embryo 06-08hr    40 embryo 08-10hr    35 embryo 10-12hr    25 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    33 embryo 18-20hr    38 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    60 white prepupae new    69 white prepupae 12hr    60 white prepupae 24hr    53 pupae 2d postWPP    45 pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day    30 adult male 05day    34 adult male 30day    29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    60 embryo 04-06hr    62 embryo 06-08hr    40 embryo 08-10hr    35 embryo 10-12hr    25 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    33 embryo 18-20hr    38 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    60 white prepupae new    69 white prepupae 12hr    60 white prepupae 24hr    53 pupae 2d postWPP    45 pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day    30 adult male 05day    34 adult male 30day    29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    60 embryo 04-06hr    62 embryo 06-08hr    40 embryo 08-10hr    35 embryo 10-12hr    25 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    33 embryo 18-20hr    38 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    60 white prepupae new    69 white prepupae 12hr    60 white prepupae 24hr    53 pupae 2d postWPP    45 pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day    30 adult male 05day    34 adult male 30day    29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr  (60) embryo 04-06hr  (62) embryo 06-08hr  (40) embryo 08-10hr  (35) embryo 10-12hr    25 embryo 12-14hr  26 embryo 14-16hr  28 embryo 16-18hr  (33) embryo 18-20hr  (38) embryo 20-22hr  (34) embryo 22-24hr  (39) larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9  (60) white prepupae new  (69) white prepupae 12hr  (60) white prepupae 24hr  (53) pupae 2d postWPP  (45) pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day  30 adult male 05day  (34) adult male 30day  29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    60 embryo 04-06hr    62 embryo 06-08hr    40 embryo 08-10hr    35 embryo 10-12hr    25 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    33 embryo 18-20hr    38 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    60 white prepupae new    69 white prepupae 12hr    60 white prepupae 24hr    53 pupae 2d postWPP    45 pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day    30 adult male 05day    34 adult male 30day    29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    60 embryo 04-06hr    62 embryo 06-08hr    40 embryo 08-10hr    35 embryo 10-12hr    25 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    33 embryo 18-20hr    38 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    19 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    60 white prepupae new    69 white prepupae 12hr    60 white prepupae 24hr    53 pupae 2d postWPP    45 pupae 3d postWPP    25 pupae 4d postWPP    23 adult male 01day    30 adult male 05day    34 adult male 30day    29 adult female 01day    20 adult female 05day    20 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    16 embryonic 1182-4H    41 embryonic GM2    45 embryonic Kc167    52 embryonic S1    92 embryonic S3    85 leg disc CME L1    26 wing disc CME-W2    33 wing disc ML-DmD8    40 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    55 wing disc ML-DmD21    24 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    58 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    31 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (32) Schneider line 2 Sg4    16 embryonic 1182-4H  (41) embryonic GM2  (45) embryonic Kc167  (52) embryonic S1  (92) embryonic S3  (85) leg disc CME L1  26 wing disc CME-W2  (33) wing disc ML-DmD8  (40) wing disc ML-DmD9  (45) wing disc ML-DmD16-c3  (55) wing disc ML-DmD21    24 wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3  (58) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  (33) CNS ML-DmBG1-c1  (49) CNS ML-DmBG2-c2  (46) tumorous blood cells mbn2  (41) ovary fGS/OSS  (78) ovary OSC  (31) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    16 embryonic 1182-4H    41 embryonic GM2    45 embryonic Kc167    52 embryonic S1    92 embryonic S3    85 leg disc CME L1    26 wing disc CME-W2    33 wing disc ML-DmD8    40 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    55 wing disc ML-DmD21    24 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    58 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    31 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    16 embryonic 1182-4H    41 embryonic GM2    45 embryonic Kc167    52 embryonic S1    92 embryonic S3    85 leg disc CME L1    26 wing disc CME-W2    33 wing disc ML-DmD8    40 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    55 wing disc ML-DmD21    24 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    58 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    31 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    16 embryonic 1182-4H    41 embryonic GM2    45 embryonic Kc167    52 embryonic S1    92 embryonic S3    85 leg disc CME L1    26 wing disc CME-W2    33 wing disc ML-DmD8    40 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    55 wing disc ML-DmD21    24 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    58 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    31 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  32 Schneider line 2 Sg4    16 embryonic 1182-4H  (41) embryonic GM2  (45) embryonic Kc167  (52) embryonic S1  (92) embryonic S3  (85) leg disc CME L1  26 wing disc CME-W2  (33) wing disc ML-DmD8  (40) wing disc ML-DmD9  (45) wing disc ML-DmD16-c3  (55) wing disc ML-DmD21    24 wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3  (58) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  (33) CNS ML-DmBG1-c1  (49) CNS ML-DmBG2-c2  (46) tumorous blood cells mbn2  (41) ovary fGS/OSS  (78) ovary OSC  31 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    16 embryonic 1182-4H    41 embryonic GM2    45 embryonic Kc167    52 embryonic S1    92 embryonic S3    85 leg disc CME L1    26 wing disc CME-W2    33 wing disc ML-DmD8    40 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    55 wing disc ML-DmD21    24 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    58 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    31 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    16 embryonic 1182-4H    41 embryonic GM2    45 embryonic Kc167    52 embryonic S1    92 embryonic S3    85 leg disc CME L1    26 wing disc CME-W2    33 wing disc ML-DmD8    40 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    55 wing disc ML-DmD21    24 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    58 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    31 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (33) cold shock, 4-day adult  (30) heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (35) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (33) cold shock, 4-day adult  30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (35) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD22235 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019890 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8954-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Smg5 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4[-]: Smg5EP2171 viable, with Scer\GAL4pnr-MD237 Smg5GD14079 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Smg5EP2171 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 Smg5EP2171 intersegmental nerve, with Scer\GAL4elav-C155 Smg5EP2171
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Smg5 Class Mutagen Stocks Known lesion Smg5c00531 piggyBac transposase 1 -- Smg5c05555 piggyBac transposase 1 -- Smg5e03996 piggyBac transposase 1 -- Smg5e04233 piggyBac transposase 1 -- Smg5EP2171 P-element activity 1 Yes Smg5Act5C.T:λ\N,T:Ivir\HA1 0 Yes Smg5c04263 piggyBac transposase 0 -- Smg5e00092 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Smg5 Class Mutagen Stocks Known lesion Smg5GD14079 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Smg5JF01554 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Smg5KK102117 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Smg5dsRNA.cGa in vitro construct - RNAi 0 Yes Smg5NIG.8954R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Smg5PIN.Act5C.T:λ\N,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Smg5RACE in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14079} NA P{KK102117} NA P{NIG.8954R} NA P{TRiP.JF01554} NA characterization construct P{mtRACE} NA P{RACE} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Smg5c00531 NA PBac{PB}Smg5c04263 NA PBac{PB}Smg5c05555 NA PBac{RB}Smg5e00092 NA PBac{RB}Smg5e03996 NA PBac{RB}Smg5e04233 NA insertion of enhancer trap P{lacW}l(2)SH2320SH2320 No insertion of mobile activating element P{EP}Smg5EP2171 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
NOT gene silencing by miRNA inferred from mutant phenotype (Rehwinkel et al., 2005) nuclear-transcribed mRNA catabolic process, nonsense-mediated decay inferred from mutant phenotype (Gatfield et al., 2003, Rehwinkel et al., 2005) NOT RNA interference inferred from mutant phenotype (Rehwinkel et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Smg5 - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Smg5 - nerfin-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Smg5 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60834 DroID - A comprehensive database of gene and protein interactions. • FBgn0019890 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34804
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6256C3 Dipteran inclusive ortholog search EOG66DM9S Insect inclusive ortholog search EOG6VMD98 Arthropod inclusive ortholog search EOG651C5M Metazoa inclusive ortholog search EOG6J488Q
Orthologs in Drosophila Species (EOG6256C3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Smg5     Drosophila simulans   Dsim\GD22031 Y   Drosophila sechellia   Dsec\GM15043 Y   Drosophila erecta   Dere\GG10174 Y   Drosophila yakuba   Dyak\GE11362 Y   Drosophila ananassae   Dana\GF15612 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21432 Y   Drosophila persimilis   Dper\GL21074 Y   Drosophila willistoni   Dwil\GK15115 Y   Drosophila virilis   Dvir\GJ18079 Y   Drosophila mojavensis   Dmoj\GI17401 Y   Drosophila grimshawi   Dgri\GH10610 Y
Orthologs in non-Drosophila Dipterans (EOG66DM9S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004986   Anopheles gambiae Malaria mosquito  Agam\AGAP008181   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801457
Orthologs in non-Dipteran Insects (EOG6VMD98)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46070   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG030443   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15359   Atta cephalotes Leafcutter ant  Acep\ACEP12903   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15797   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19610   Linepithema humile Argentine ant  Lhum\LH22933   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25664   Solenopsis invicta Red fire ant  Sinv\SINV17537   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008597   Bombyx mori Silkmoth  Bmor\BGIBMGA001478   Pediculus humanus Human body louse  Phum\PHUM245150   Tribolium castaneum Red flour beetle  Tcas\TC001202
Orthologs in non-Insect Arthropods (EOG651C5M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RPB1   Daphnia pulex Water flea  Dpux\JGI_V11_305898   Ixodes scapularis Deer tick  Isca\ISCW005323   Ixodes scapularis Deer tick  Isca\ISCW005326
Orthologs in non-Arthropod Metazoa (EOG6J488Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026456gn   Danio rerio Zebrafish  Drer\smg5   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033791   Gallus gallus Domestic chicken  Ggal\ENSGALG00000009011   Mus musculus House mouse  Mmus\Smg5   Mus musculus House mouse  Mmus\A930017M01Rik   Rattus norvegicus Norway rat  Rnor\Smg5   Rattus norvegicus Norway rat  Rnor\RGD1309489   Homo sapiens Human  Hsap\SMG5
Human Orthologs (1)
Gene OMIM HGNC Hsap\SMG5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22031 Drosophila sechellia Dsec\GM15043 Drosophila erecta Dere\GG10174 Drosophila yakuba Dyak\GE11362 Drosophila ananassae Dana\GF15612 Drosophila pseudoobscura pseudoobscura Dpse\GA21432 Drosophila persimilis Dper\GL21074 Drosophila willistoni Dwil\GK15115 Drosophila virilis Dvir\GJ18079 Drosophila mojavensis Dmoj\GI17401 Drosophila grimshawi Dgri\GH10610
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	17031 w1118; P{EP}Smg5EP2171 31090 y1 v1; P{TRiP.JF01554}attP2 25167 w1118; PBac{RB}Smg5e04233/CyO
Harvard	- PBac{PB}Smg5c00531 - PBac{PB}Smg5c05555 - PBac{RB}Smg5e03996
VDRC	v107160 P{KK102117}VIE-260B v23659 w1118; P{GD14079}v23659
Genomic Clones ( 1 )
	BACR16P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 119 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22235 LD36341 LD42783
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09731 AT11474 AT13205 AT21981 AT29807 GH06653 GH09924 GH10736 LD02558 LD12350 LD20278 LD22301 LD29084 RE45681 RE71193 RE72702 SD08396 SD12719
Other clones	1259 5014 8374 57288 98046 101823 109001 153937 214249.3 275371 CK01.89D.G5 EC250513 EC254898 EC254940 EK070627 EK106319 EK122657 EK123552 EK177461 EK220459 EK228853 EK257442 EK263834 EK303151 EP15963 EP16718 FGC008F08 LD06162 RP004015104 RP004020109 RP004036085 RP004065670 RP004076250 RP004082481 RP004086732 RP004100929 RP004112741 RP004117357 RP004119819 RP004138330 RP004145665 RP004157602 RP004158936 RP004161181 RP004166139 RP004174767 RP004190129 RP004198195 RP004198805 RP004200184 RP004204463 RP004209381 RP004209444 RP004218417 RP004224640 RP004228390 RP004235906 RP004245097 RP004246554 RP004252541 RP004255379 RP004264212 RP004264984 RP004277588 RP004296650 RP004303708 RP004305177 RP004330910 RP004344627 RP004349327 RP004349711 RP004354841 RP004356064 RP004366859 RP004373492 RP004377635 RP004378745 RP004388567 RP004418228 RP004421772 RP004438066 RP004445041 RP004453308 RP004456496 RP004456523 RP004459111 RP004463458 RP004466235 RP004472730 RP004480889 RP004498329 RP004501668 RP004504650 RP004521587 RP004533086 RP004540579 RP004546839 RP004547376
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0019890 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34804
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: anon-34Ea CG8954 (Guan, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Smg5 is required for nonsense-mediate mRNA decay. (Gatfield et al., 2003) Transcription unit identified during molecular analysis of the Ance region. Smg5 and Ance are divergently transcribed and their 5' ends are approximately 4kb apart. (Tatei et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135841 NM_165069 RefSeq (Proteins) • NP_609685 NP_723851 DDBJ / EMBL / GenBank • AA202382 AA246968 AA540559 AA816812 AA820087 AA952054 AAF44833 AAF53351 AAF53352 AAL13934 AAL39640 AE003408 AI516747 AJ556817 AQ073365 AW942629 AW943626 AY058705 AY069495 BG637854 BH634792 CAD89222 CZ466529 CZ469119 CZ470095 CZ477997 CZ481753 CZ481978 L80114 Entrez Gene - A searchable database of RefSeq genes. • 34804 UniProtKB/TrEMBL • Q8T080 Q9V414 Q95TL1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA/RNA-binding domain, Est1-type (IPR018834) Nucleotide binding protein, PINc (IPR006596) Telomerase activating protein Est1 (IPR019458) PIN domain (IPR002716) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22235
Linkouts
	BioGRID - A database of protein and genetic interactions • 60834 DroID - A comprehensive database of gene and protein interactions. • FBgn0019890 DRSC - Results from RNAi screens. • FBgn0019890 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019890 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8954-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0019890 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34804 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34804 modMine - Data generated by the modENCODE project. • FBgn0019890
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-34Ea (Gatfield et al., 2003, ) BG:DS08220.2 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG8954 (Bianchi-Frias et al., 2004, Ashburner et al., 1999, Ashburner et al., 1999, Moorman et al., 2006, Rehwinkel et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2008) dSMG5 (Glavan et al., 2006) SMG5 (Gatfield et al., 2003, Rehwinkel et al., 2005, Rehwinkel et al., 2005, Huntzinger et al., 2008) Smg5 (Metzstein et al., 2007, Dworkin et al., 2009, Rehmsmeier et al., 2004, Pospisilik et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Frizzell et al., 2012) smg5 (Avery et al., 2011) unnamed (Kraut et al., 2001, Tatei et al., 1995)
Name Synonym	Smg5 (Rehmsmeier et al., 2004)
Secondary FlyBase IDs
	FBgn0027901
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Frizzell et al., 2012, RNA 18(8): 1475--1486 Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. [FBrf0218868] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Avery et al., 2011, RNA 17(4): 624--638 Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. [FBrf0213282] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...