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Gene Dmel\Surf4

General Information
Symbol	Dmel\Surf4	Species	D. melanogaster
Name	Surfeit 4	Annotation symbol	CG6202
Feature type	protein_coding_gene	FlyBase ID	FBgn0019925
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	SURF-4
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88F1-88F1	Sequence location	3R:11,169,375..11,171,898 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Surfeit 4 is referred to in FlyBase by the symbol Dmel\Surf4 (CG6202, FBgn0019925). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: lateral inhibition. 6 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Surfeit locus 4. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-18 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult hindgut, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1640313_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Surf4. Gene sequence location is 3R:11169375..11171898.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88F1-88F1   Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88F-88F     (Fried, 1997.9.15) 88F3-88F4   (determined by in situ hybridisation)   (Armes and Fried, 1996)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Surf4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Surf4-RA FBtr0083117  NM_057874   1641   270 Surf4-RB FBtr0083118  NM_169647   1578   270
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Surf4-PA   FBpp0082571   30.5   270   9.31     NP_477222   AAF55176 Surf4-PB   FBpp0082572   30.5   270   9.31     NP_732016   AAN13656
Additional Polypeptide Data & Comments
Reported size (kDa)	270 (aa) (Armes and Fried, 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Surfeit locus 4 (IPR002995)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439642   AA440755   AA802698   AE014297 AAF55176   AE014297 AAN13656   AI113680   AI256961   AI387721   AI388419   AI389904   AY118406 AAM48435   BF488504   BF505937   BI162720   BI162721   BI163025   BI164650   BI165585   BI213712   BI214547   BI216082   BI228790   BI235391   BI235934   BI239644   BI240406   BI241864   BI352114   BI361401   BI361524   BI363136   BI363756   BI366053   BI374628   BI483476   BI569647   BI580439   BI589947   BI592246   BI605464   BI605853   BI606329   BI606334   BI623184   BI625426   BI628608   BP550822   BP550823   BP551992   BP551993   BP559014   BP559015   CA806504   CL868609   CO156853   CO269911   CO272646   CO272841   CO275282   CO277374   CO279435   CO297949   CO336526   CO343179   CZ473828   DQ440426   EC051888   EC051966   EC052391   EC052468   EC052960   EC053459   EC053469   EC053952   EC054924   EC057092   EC057093   EC059692   EC060377   EC089704   EC209582   EC220623   EC232390   EC257337   EC263270   EC264030   EL874315   ES692210   ES692215   EV578652   EV597162   GH747784   GH747855   GH751168   GH751464   GH751637   GH752692   GH752917   GH753458   GH753633   GH756166   GH756854   GH757412   GH758115   GH758132   GH758263   GH758726   GH758798   GH758908   GH759045   GH759079   GH759860   GH772312   GH772800   GH773156   GH773844   GH775282   GH775685   GH775708   GH775797   GH776552   GH777100   GH778846   GH779989   GH780236   GH780376   GH780434   GH780618   GH782662   GH783031   GH783837   GH785167   GH786015   GH786334   GH790246   GH790261   GH790832   GH791708   GH792223   GH792297   GH792444   GH793386   GH794132   GH796158   GH798605   GH800114   GH800318   GH801000   GH801054   GH801256   GH801260   GH804130   GH804168   GH804247   GH806337   GH806340   GH806661   GH808358   GH809758   GH809921   GH810734   GH811750   GH812282   GH812669   GH813104   GH813403   GH814356   GH816323   GH816593   GH816670   GH816808   GH817408   GH817542   GH818625   GH821034   GH821038   GH821558   GH821795   GH822643   GH824894   GH826382   GH827386   GH827940   GH828506   GH829029   GH829485   GH829990   GH830032   GH830267   GH832367   GH832389   GH832617   GH834087   GH834611   GH836293   GH837206   GH838225   GH838265   GH838572   GH838841   GH840748   GH843451   GH843777   GH844367   GH844837   GH846920   GH847039   GH847755   GH848213   GH849733   GH850752   GH850988   GH851790   GH852011   GH853317   GH855769   GH856549   GH856649   GH856909   GH859154   GH860830   GH863486   GH864820   GH865134   GH865221   GH865584   GH865670   GH866396   GH866400   GH868236   GH868349   GH868744   GH869050   GH869625   GH869868   GH870202   GH870369   GH871190   GH871343   GH872776   GH873069   GH873568   GH874523   GH875630   GH876390   GH879996   GH880918   GH883295   GH884755   GH884772   GH885806   GH888493   GH889832   GH891196   GH891939   GH892153   GH892329   GH895108   GH898706   GH898732   GH899423   GH901426   GH902441   GH904183   GH905855   GH907411   GH908124   GH908460   GH909303   GH909651   GH909935   GH909963   GH910024   GH913661   GH914213   GH914415   GH915643   GH915678   GH916966   GH917101   GH917646   GH917683   GH918090   GH918186   GH918223   GH918665   GH919120   GH919176   GH919296   GH919569   GH919765   GH920310   GH920628   GH922132   GH922202   GH922314   GH922883   GH923063   GH923556   GH924106   GH924310   GH924792   GH925277   GH926162   GH927015   GH927598   GH927781   GH928465   GH928779   GH930753   GH930831   GH932488   GH933217   GH934463   GH937478   GH937951   GH938413   GH938654   GH940011   GH942468   Y14823 CAA75100
UniProtKB/Swiss-Prot	O18405
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 7 -- 8   head mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   head mesoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult hindgut, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut    972.6 Larval Hindgut    716 Larval Malpighian Tubules    731.4 Larval Fat Body    944.7 Larval Salivary Gland    3488.7 Larval Trachea    927.475 Larval Carcass    947.775 Adult Head    616.7 Adult Eye    676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop    635.5 Adult Midgut    794 Adult Hindgut    455.7 Adult Malpighian Tubules    609 Adult Fat Body    1354.6 Adult Salivary Gland    3305 Adult Heart    921.175 Adult VirginFemale Spermatheca    991.3 Adult InseminatedFemale Spermatheca    1154.4 Adult Ovary    534.8 Adult Testis    150.7 Adult Male Accessory Gland    2570.6 Adult Carcass    727.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut  (972.6) Larval Hindgut  (716) Larval Malpighian Tubules  (731.4) Larval Fat Body  (944.7) Larval Salivary Gland  (3488.7) Larval Trachea  (927.475) Larval Carcass  (947.775) Adult Head  (616.7) Adult Eye  (676.9) Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop  (635.5) Adult Midgut  (794) Adult Hindgut    455.7 Adult Malpighian Tubules  (609) Adult Fat Body  (1354.6) Adult Salivary Gland  (3305) Adult Heart  (921.175) Adult VirginFemale Spermatheca  (991.3) Adult InseminatedFemale Spermatheca  (1154.4) Adult Ovary  534.8 Adult Testis    150.7 Adult Male Accessory Gland  (2570.6) Adult Carcass  (727.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut    972.6 Larval Hindgut    716 Larval Malpighian Tubules    731.4 Larval Fat Body    944.7 Larval Salivary Gland  (3488.7) Larval Trachea    927.475 Larval Carcass    947.775 Adult Head    616.7 Adult Eye    676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop    635.5 Adult Midgut    794 Adult Hindgut    455.7 Adult Malpighian Tubules    609 Adult Fat Body  (1354.6) Adult Salivary Gland  (3305) Adult Heart    921.175 Adult VirginFemale Spermatheca    991.3 Adult InseminatedFemale Spermatheca  (1154.4) Adult Ovary    534.8 Adult Testis    150.7 Adult Male Accessory Gland  (2570.6) Adult Carcass    727.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut    972.6 Larval Hindgut    716 Larval Malpighian Tubules    731.4 Larval Fat Body    944.7 Larval Salivary Gland    3488.7 Larval Trachea    927.475 Larval Carcass    947.775 Adult Head    616.7 Adult Eye    676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop    635.5 Adult Midgut    794 Adult Hindgut    455.7 Adult Malpighian Tubules    609 Adult Fat Body    1354.6 Adult Salivary Gland    3305 Adult Heart    921.175 Adult VirginFemale Spermatheca    991.3 Adult InseminatedFemale Spermatheca    1154.4 Adult Ovary    534.8 Adult Testis    150.7 Adult Male Accessory Gland    2570.6 Adult Carcass    727.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut    972.6 Larval Hindgut    716 Larval Malpighian Tubules    731.4 Larval Fat Body    944.7 Larval Salivary Gland    3488.7 Larval Trachea    927.475 Larval Carcass    947.775 Adult Head    616.7 Adult Eye    676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop    635.5 Adult Midgut    794 Adult Hindgut    455.7 Adult Malpighian Tubules    609 Adult Fat Body    1354.6 Adult Salivary Gland    3305 Adult Heart    921.175 Adult VirginFemale Spermatheca    991.3 Adult InseminatedFemale Spermatheca    1154.4 Adult Ovary    534.8 Adult Testis    150.7 Adult Male Accessory Gland    2570.6 Adult Carcass    727.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut  (972.6) Larval Hindgut  716 Larval Malpighian Tubules  731.4 Larval Fat Body  (944.7) Larval Salivary Gland  (3488.7) Larval Trachea  (927.475) Larval Carcass  (947.775) Adult Head  616.7 Adult Eye  676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop  635.5 Adult Midgut  794 Adult Hindgut    455.7 Adult Malpighian Tubules  609 Adult Fat Body  (1354.6) Adult Salivary Gland  (3305) Adult Heart  (921.175) Adult VirginFemale Spermatheca  (991.3) Adult InseminatedFemale Spermatheca  (1154.4) Adult Ovary  534.8 Adult Testis    150.7 Adult Male Accessory Gland  (2570.6) Adult Carcass  727.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut    972.6 Larval Hindgut    716 Larval Malpighian Tubules    731.4 Larval Fat Body    944.7 Larval Salivary Gland  (3488.7) Larval Trachea    927.475 Larval Carcass    947.775 Adult Head    616.7 Adult Eye    676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop    635.5 Adult Midgut    794 Adult Hindgut    455.7 Adult Malpighian Tubules    609 Adult Fat Body  1354.6 Adult Salivary Gland  (3305) Adult Heart    921.175 Adult VirginFemale Spermatheca    991.3 Adult InseminatedFemale Spermatheca  1154.4 Adult Ovary    534.8 Adult Testis    150.7 Adult Male Accessory Gland  (2570.6) Adult Carcass    727.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    431.15 Larval Midgut    972.6 Larval Hindgut    716 Larval Malpighian Tubules    731.4 Larval Fat Body    944.7 Larval Salivary Gland    3488.7 Larval Trachea    927.475 Larval Carcass    947.775 Adult Head    616.7 Adult Eye    676.9 Adult Brain    339.6 Adult Thoracic-Abdominal Ganglion    317.3 Adult Crop    635.5 Adult Midgut    794 Adult Hindgut    455.7 Adult Malpighian Tubules    609 Adult Fat Body    1354.6 Adult Salivary Gland    3305 Adult Heart    921.175 Adult VirginFemale Spermatheca    991.3 Adult InseminatedFemale Spermatheca    1154.4 Adult Ovary    534.8 Adult Testis    150.7 Adult Male Accessory Gland    2570.6 Adult Carcass    727.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    616.7   NA  Eye    676.9   NA  Brain    339.6   431.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    317.3   NA  Crop    635.5   972.6  Midgut    794   716  Hindgut    455.7   731.4  Malpighian Tubules    609   944.7  Fat Body    1354.6   3488.7  Salivary Gland    3305   NA  Heart    921.175   927.475  Trachea    NA   NA  VirginFemale Spermatheca    991.3   NA  InseminatedFemale Spermatheca    1154.4   NA  Ovary    534.8   NA  Testis    150.7   NA  Male Accessory Gland    2570.6   947.775  Carcass    727.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    87 central nervous system, larvae L3    80 central nervous system, pupae P8    71 head, virgin 1-day female    128 head, virgin 4-day female    80 head, virgin 20-day female    97 head, mated 1-day female    88 head, mated 4-day female    84 head, mated 20-day female    98 head, mated 1-day male    72 head, mated 4-day male    85 head, mated 20-day male    95 salivary gland, larvae L3 wandering    127 salivary gland, white prepupae    144 digestive system, larvae L3 wandering    93 digestive system, 1-day adult    102 digestive system, 4-day adult    90 digestive system, 20-day adult    70 fat body, larvae L3 wandering    130 fat body, white prepupae    131 fat body, pupae P8    134 carcass, larvae L3 wandering    112 carcass, 1-day adult    97 carcass, 4-day adult    132 carcass, 20-day adult    106 ovary, virgin 4-day female    154 ovary, mated 4-day female    134 testis, mated 4-day male    47 accessory gland, mated 4-day male    215 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (87) central nervous system, larvae L3  (80) central nervous system, pupae P8  (71) head, virgin 1-day female  (128) head, virgin 4-day female  (80) head, virgin 20-day female  (97) head, mated 1-day female  (88) head, mated 4-day female  (84) head, mated 20-day female  (98) head, mated 1-day male  (72) head, mated 4-day male  (85) head, mated 20-day male  (95) salivary gland, larvae L3 wandering  (127) salivary gland, white prepupae  (144) digestive system, larvae L3 wandering  (93) digestive system, 1-day adult  (102) digestive system, 4-day adult  (90) digestive system, 20-day adult  (70) fat body, larvae L3 wandering  (130) fat body, white prepupae  (131) fat body, pupae P8  (134) carcass, larvae L3 wandering  (112) carcass, 1-day adult  (97) carcass, 4-day adult  (132) carcass, 20-day adult  (106) ovary, virgin 4-day female  (154) ovary, mated 4-day female  (134) testis, mated 4-day male  (47) accessory gland, mated 4-day male  (215) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    87 central nervous system, larvae L3    80 central nervous system, pupae P8    71 head, virgin 1-day female  (128) head, virgin 4-day female    80 head, virgin 20-day female    97 head, mated 1-day female    88 head, mated 4-day female    84 head, mated 20-day female    98 head, mated 1-day male    72 head, mated 4-day male    85 head, mated 20-day male    95 salivary gland, larvae L3 wandering  (127) salivary gland, white prepupae  (144) digestive system, larvae L3 wandering    93 digestive system, 1-day adult  102 digestive system, 4-day adult    90 digestive system, 20-day adult    70 fat body, larvae L3 wandering  (130) fat body, white prepupae  (131) fat body, pupae P8  (134) carcass, larvae L3 wandering  (112) carcass, 1-day adult    97 carcass, 4-day adult  (132) carcass, 20-day adult  106 ovary, virgin 4-day female  (154) ovary, mated 4-day female  (134) testis, mated 4-day male    47 accessory gland, mated 4-day male  (215) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    87 central nervous system, larvae L3    80 central nervous system, pupae P8    71 head, virgin 1-day female    128 head, virgin 4-day female    80 head, virgin 20-day female    97 head, mated 1-day female    88 head, mated 4-day female    84 head, mated 20-day female    98 head, mated 1-day male    72 head, mated 4-day male    85 head, mated 20-day male    95 salivary gland, larvae L3 wandering    127 salivary gland, white prepupae    144 digestive system, larvae L3 wandering    93 digestive system, 1-day adult    102 digestive system, 4-day adult    90 digestive system, 20-day adult    70 fat body, larvae L3 wandering    130 fat body, white prepupae    131 fat body, pupae P8    134 carcass, larvae L3 wandering    112 carcass, 1-day adult    97 carcass, 4-day adult    132 carcass, 20-day adult    106 ovary, virgin 4-day female    154 ovary, mated 4-day female    134 testis, mated 4-day male    47 accessory gland, mated 4-day male    215 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    87 central nervous system, larvae L3    80 central nervous system, pupae P8    71 head, virgin 1-day female    128 head, virgin 4-day female    80 head, virgin 20-day female    97 head, mated 1-day female    88 head, mated 4-day female    84 head, mated 20-day female    98 head, mated 1-day male    72 head, mated 4-day male    85 head, mated 20-day male    95 salivary gland, larvae L3 wandering    127 salivary gland, white prepupae    144 digestive system, larvae L3 wandering    93 digestive system, 1-day adult    102 digestive system, 4-day adult    90 digestive system, 20-day adult    70 fat body, larvae L3 wandering    130 fat body, white prepupae    131 fat body, pupae P8    134 carcass, larvae L3 wandering    112 carcass, 1-day adult    97 carcass, 4-day adult    132 carcass, 20-day adult    106 ovary, virgin 4-day female    154 ovary, mated 4-day female    134 testis, mated 4-day male    47 accessory gland, mated 4-day male    215 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (87) central nervous system, larvae L3  (80) central nervous system, pupae P8  (71) head, virgin 1-day female  (128) head, virgin 4-day female  (80) head, virgin 20-day female  (97) head, mated 1-day female  (88) head, mated 4-day female  (84) head, mated 20-day female  (98) head, mated 1-day male  (72) head, mated 4-day male  (85) head, mated 20-day male  (95) salivary gland, larvae L3 wandering  (127) salivary gland, white prepupae  (144) digestive system, larvae L3 wandering  (93) digestive system, 1-day adult  (102) digestive system, 4-day adult  (90) digestive system, 20-day adult  (70) fat body, larvae L3 wandering  (130) fat body, white prepupae  (131) fat body, pupae P8  (134) carcass, larvae L3 wandering  (112) carcass, 1-day adult  (97) carcass, 4-day adult  (132) carcass, 20-day adult  (106) ovary, virgin 4-day female  (154) ovary, mated 4-day female  (134) testis, mated 4-day male  (47) accessory gland, mated 4-day male  (215) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    87 central nervous system, larvae L3    80 central nervous system, pupae P8    71 head, virgin 1-day female  128 head, virgin 4-day female    80 head, virgin 20-day female    97 head, mated 1-day female    88 head, mated 4-day female    84 head, mated 20-day female    98 head, mated 1-day male    72 head, mated 4-day male    85 head, mated 20-day male    95 salivary gland, larvae L3 wandering  127 salivary gland, white prepupae  (144) digestive system, larvae L3 wandering    93 digestive system, 1-day adult  102 digestive system, 4-day adult    90 digestive system, 20-day adult    70 fat body, larvae L3 wandering  130 fat body, white prepupae  131 fat body, pupae P8  134 carcass, larvae L3 wandering  112 carcass, 1-day adult    97 carcass, 4-day adult  132 carcass, 20-day adult  106 ovary, virgin 4-day female  (154) ovary, mated 4-day female  134 testis, mated 4-day male    47 accessory gland, mated 4-day male  (215) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    87 central nervous system, larvae L3    80 central nervous system, pupae P8    71 head, virgin 1-day female    128 head, virgin 4-day female    80 head, virgin 20-day female    97 head, mated 1-day female    88 head, mated 4-day female    84 head, mated 20-day female    98 head, mated 1-day male    72 head, mated 4-day male    85 head, mated 20-day male    95 salivary gland, larvae L3 wandering    127 salivary gland, white prepupae    144 digestive system, larvae L3 wandering    93 digestive system, 1-day adult    102 digestive system, 4-day adult    90 digestive system, 20-day adult    70 fat body, larvae L3 wandering    130 fat body, white prepupae    131 fat body, pupae P8    134 carcass, larvae L3 wandering    112 carcass, 1-day adult    97 carcass, 4-day adult    132 carcass, 20-day adult    106 ovary, virgin 4-day female    154 ovary, mated 4-day female    134 testis, mated 4-day male    47 accessory gland, mated 4-day male    215 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-18 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    47 embryo 04-06hr    37 embryo 06-08hr    88 embryo 08-10hr    116 embryo 10-12hr    145 embryo 12-14hr    149 embryo 14-16hr    198 embryo 16-18hr    157 embryo 18-20hr    87 embryo 20-22hr    65 embryo 22-24hr    64 larva L1    88 larva L2    199 larva L3 12hr old    135 larva L3 puffstage 1-2    89 larva L3 puffstage 3-6    88 larva L3 puffstage 7-9    94 white prepupae new    91 white prepupae 12hr    55 white prepupae 24hr    60 pupae 2d postWPP    124 pupae 3d postWPP    55 pupae 4d postWPP    43 adult male 01day    71 adult male 05day    65 adult male 30day    61 adult female 01day    68 adult female 05day    90 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (110) embryo 02-04hr  (47) embryo 04-06hr  (37) embryo 06-08hr  (88) embryo 08-10hr  (116) embryo 10-12hr  (145) embryo 12-14hr  (149) embryo 14-16hr  (198) embryo 16-18hr  (157) embryo 18-20hr  (87) embryo 20-22hr  (65) embryo 22-24hr  (64) larva L1  (88) larva L2  (199) larva L3 12hr old  (135) larva L3 puffstage 1-2  (89) larva L3 puffstage 3-6  (88) larva L3 puffstage 7-9  (94) white prepupae new  (91) white prepupae 12hr  (55) white prepupae 24hr  (60) pupae 2d postWPP  (124) pupae 3d postWPP  (55) pupae 4d postWPP  (43) adult male 01day  (71) adult male 05day  (65) adult male 30day  (61) adult female 01day  (68) adult female 05day  (90) adult female 30day  (91) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (110) embryo 02-04hr    47 embryo 04-06hr    37 embryo 06-08hr    88 embryo 08-10hr  (116) embryo 10-12hr  (145) embryo 12-14hr  (149) embryo 14-16hr  (198) embryo 16-18hr  (157) embryo 18-20hr    87 embryo 20-22hr    65 embryo 22-24hr    64 larva L1    88 larva L2  (199) larva L3 12hr old  (135) larva L3 puffstage 1-2    89 larva L3 puffstage 3-6    88 larva L3 puffstage 7-9    94 white prepupae new    91 white prepupae 12hr    55 white prepupae 24hr    60 pupae 2d postWPP  (124) pupae 3d postWPP    55 pupae 4d postWPP    43 adult male 01day    71 adult male 05day    65 adult male 30day    61 adult female 01day    68 adult female 05day    90 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    47 embryo 04-06hr    37 embryo 06-08hr    88 embryo 08-10hr    116 embryo 10-12hr    145 embryo 12-14hr    149 embryo 14-16hr    198 embryo 16-18hr    157 embryo 18-20hr    87 embryo 20-22hr    65 embryo 22-24hr    64 larva L1    88 larva L2    199 larva L3 12hr old    135 larva L3 puffstage 1-2    89 larva L3 puffstage 3-6    88 larva L3 puffstage 7-9    94 white prepupae new    91 white prepupae 12hr    55 white prepupae 24hr    60 pupae 2d postWPP    124 pupae 3d postWPP    55 pupae 4d postWPP    43 adult male 01day    71 adult male 05day    65 adult male 30day    61 adult female 01day    68 adult female 05day    90 adult female 30day    91 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    47 embryo 04-06hr    37 embryo 06-08hr    88 embryo 08-10hr    116 embryo 10-12hr    145 embryo 12-14hr    149 embryo 14-16hr    198 embryo 16-18hr    157 embryo 18-20hr    87 embryo 20-22hr    65 embryo 22-24hr    64 larva L1    88 larva L2    199 larva L3 12hr old    135 larva L3 puffstage 1-2    89 larva L3 puffstage 3-6    88 larva L3 puffstage 7-9    94 white prepupae new    91 white prepupae 12hr    55 white prepupae 24hr    60 pupae 2d postWPP    124 pupae 3d postWPP    55 pupae 4d postWPP    43 adult male 01day    71 adult male 05day    65 adult male 30day    61 adult female 01day    68 adult female 05day    90 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (110) embryo 02-04hr  (47) embryo 04-06hr  (37) embryo 06-08hr  (88) embryo 08-10hr  (116) embryo 10-12hr  (145) embryo 12-14hr  (149) embryo 14-16hr  (198) embryo 16-18hr  (157) embryo 18-20hr  (87) embryo 20-22hr  (65) embryo 22-24hr  (64) larva L1  (88) larva L2  (199) larva L3 12hr old  (135) larva L3 puffstage 1-2  (89) larva L3 puffstage 3-6  (88) larva L3 puffstage 7-9  (94) white prepupae new  (91) white prepupae 12hr  (55) white prepupae 24hr  (60) pupae 2d postWPP  (124) pupae 3d postWPP  (55) pupae 4d postWPP  (43) adult male 01day  (71) adult male 05day  (65) adult male 30day  (61) adult female 01day  (68) adult female 05day  (90) adult female 30day  (91) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  110 embryo 02-04hr    47 embryo 04-06hr    37 embryo 06-08hr    88 embryo 08-10hr  116 embryo 10-12hr  (145) embryo 12-14hr  (149) embryo 14-16hr  (198) embryo 16-18hr  (157) embryo 18-20hr    87 embryo 20-22hr    65 embryo 22-24hr    64 larva L1    88 larva L2  (199) larva L3 12hr old  135 larva L3 puffstage 1-2    89 larva L3 puffstage 3-6    88 larva L3 puffstage 7-9    94 white prepupae new    91 white prepupae 12hr    55 white prepupae 24hr    60 pupae 2d postWPP  124 pupae 3d postWPP    55 pupae 4d postWPP    43 adult male 01day    71 adult male 05day    65 adult male 30day    61 adult female 01day    68 adult female 05day    90 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    47 embryo 04-06hr    37 embryo 06-08hr    88 embryo 08-10hr    116 embryo 10-12hr    145 embryo 12-14hr    149 embryo 14-16hr    198 embryo 16-18hr    157 embryo 18-20hr    87 embryo 20-22hr    65 embryo 22-24hr    64 larva L1    88 larva L2    199 larva L3 12hr old    135 larva L3 puffstage 1-2    89 larva L3 puffstage 3-6    88 larva L3 puffstage 7-9    94 white prepupae new    91 white prepupae 12hr    55 white prepupae 24hr    60 pupae 2d postWPP    124 pupae 3d postWPP    55 pupae 4d postWPP    43 adult male 01day    71 adult male 05day    65 adult male 30day    61 adult female 01day    68 adult female 05day    90 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    182 Schneider line 2 Sg4    165 embryonic 1182-4H    141 embryonic GM2    184 embryonic Kc167    60 embryonic S1    134 embryonic S3    258 leg disc CME L1    221 wing disc CME-W2    143 wing disc ML-DmD8    108 wing disc ML-DmD9    109 wing disc ML-DmD16-c3    129 wing disc ML-DmD21    130 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    147 antennal disc ML-DmD20-c5    200 mixed discs ML-DmD4-c1    174 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    120 tumorous blood cells mbn2    164 ovary fGS/OSS    84 ovary OSC    93 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (182) Schneider line 2 Sg4  (165) embryonic 1182-4H  (141) embryonic GM2  (184) embryonic Kc167  (60) embryonic S1  (134) embryonic S3  (258) leg disc CME L1  (221) wing disc CME-W2  (143) wing disc ML-DmD8  (108) wing disc ML-DmD9  (109) wing disc ML-DmD16-c3  (129) wing disc ML-DmD21  (130) wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3  (119) eye-antennal disc ML-DmD11  (147) antennal disc ML-DmD20-c5  (200) mixed discs ML-DmD4-c1  (174) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (120) tumorous blood cells mbn2  (164) ovary fGS/OSS  (84) ovary OSC  (93) ovary OSS  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (182) Schneider line 2 Sg4  (165) embryonic 1182-4H  (141) embryonic GM2  (184) embryonic Kc167    60 embryonic S1  (134) embryonic S3  (258) leg disc CME L1  (221) wing disc CME-W2  (143) wing disc ML-DmD8  (108) wing disc ML-DmD9  (109) wing disc ML-DmD16-c3  (129) wing disc ML-DmD21  (130) wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3  (119) eye-antennal disc ML-DmD11  (147) antennal disc ML-DmD20-c5  (200) mixed discs ML-DmD4-c1  (174) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (120) tumorous blood cells mbn2  (164) ovary fGS/OSS    84 ovary OSC    93 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    182 Schneider line 2 Sg4    165 embryonic 1182-4H    141 embryonic GM2    184 embryonic Kc167    60 embryonic S1    134 embryonic S3    258 leg disc CME L1    221 wing disc CME-W2    143 wing disc ML-DmD8    108 wing disc ML-DmD9    109 wing disc ML-DmD16-c3    129 wing disc ML-DmD21    130 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    147 antennal disc ML-DmD20-c5    200 mixed discs ML-DmD4-c1    174 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    120 tumorous blood cells mbn2    164 ovary fGS/OSS    84 ovary OSC    93 ovary OSS    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    182 Schneider line 2 Sg4    165 embryonic 1182-4H    141 embryonic GM2    184 embryonic Kc167    60 embryonic S1    134 embryonic S3    258 leg disc CME L1    221 wing disc CME-W2    143 wing disc ML-DmD8    108 wing disc ML-DmD9    109 wing disc ML-DmD16-c3    129 wing disc ML-DmD21    130 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    147 antennal disc ML-DmD20-c5    200 mixed discs ML-DmD4-c1    174 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    120 tumorous blood cells mbn2    164 ovary fGS/OSS    84 ovary OSC    93 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (182) Schneider line 2 Sg4  (165) embryonic 1182-4H  (141) embryonic GM2  (184) embryonic Kc167  (60) embryonic S1  (134) embryonic S3  (258) leg disc CME L1  (221) wing disc CME-W2  (143) wing disc ML-DmD8  (108) wing disc ML-DmD9  (109) wing disc ML-DmD16-c3  (129) wing disc ML-DmD21  (130) wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3  (119) eye-antennal disc ML-DmD11  (147) antennal disc ML-DmD20-c5  (200) mixed discs ML-DmD4-c1  (174) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (120) tumorous blood cells mbn2  (164) ovary fGS/OSS  (84) ovary OSC  (93) ovary OSS  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (182) Schneider line 2 Sg4  (165) embryonic 1182-4H  141 embryonic GM2  (184) embryonic Kc167    60 embryonic S1  134 embryonic S3  (258) leg disc CME L1  (221) wing disc CME-W2  143 wing disc ML-DmD8  108 wing disc ML-DmD9  109 wing disc ML-DmD16-c3  129 wing disc ML-DmD21  130 wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3  119 eye-antennal disc ML-DmD11  (147) antennal disc ML-DmD20-c5  (200) mixed discs ML-DmD4-c1  (174) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  120 tumorous blood cells mbn2  (164) ovary fGS/OSS    84 ovary OSC    93 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    182 Schneider line 2 Sg4    165 embryonic 1182-4H    141 embryonic GM2    184 embryonic Kc167    60 embryonic S1    134 embryonic S3    258 leg disc CME L1    221 wing disc CME-W2    143 wing disc ML-DmD8    108 wing disc ML-DmD9    109 wing disc ML-DmD16-c3    129 wing disc ML-DmD21    130 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    147 antennal disc ML-DmD20-c5    200 mixed discs ML-DmD4-c1    174 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    120 tumorous blood cells mbn2    164 ovary fGS/OSS    84 ovary OSC    93 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    55 cold shock, 4-day adult    48 heat shock, 4-day adult    89 Cadmium 50 mM 6 hrs, larvae L3    101 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    110 Cadmium 100 mM 48 hrs, 4-day adult    106 Copper 0.5 mM 12 hrs, larvae L3    64 Copper 15 mM 48 hrs, 4-day adult    143 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    111 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    127 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    94 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (55) cold shock, 4-day adult  (48) heat shock, 4-day adult  (89) Cadmium 50 mM 6 hrs, larvae L3  (101) Cadmium 50 mM 12 hrs, larvae L3  (114) Cadmium 50 mM 48 hrs, 4-day adult  (110) Cadmium 100 mM 48 hrs, 4-day adult  (106) Copper 0.5 mM 12 hrs, larvae L3  (64) Copper 15 mM 48 hrs, 4-day adult  (143) Zinc 5 mM 12 hrs, larvae L3  (84) Zinc 4.5 mM 48 hrs, 4-day adult  (111) Ethanol 2.5% 3 hrs, larvae L3  (74) Ethanol 5% 3 hrs, larvae L3  (127) Ethanol 10% 3 hrs, larvae L3  (96) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (88) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (112) Caffeine 25 mg/ml 48 hrs, 4-day adult  (77) Paraquat 5 mM 48 hrs, 4-day adult  (94) Paraquat 10 mM 48 hrs, 4-day adult  (64) Rotenone 2 μg 12 hrs, larvae L3  (115) Rotenone 8 μg 12 hrs, larvae L3  (91) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    55 cold shock, 4-day adult    48 heat shock, 4-day adult    89 Cadmium 50 mM 6 hrs, larvae L3  101 Cadmium 50 mM 12 hrs, larvae L3  (114) Cadmium 50 mM 48 hrs, 4-day adult  (110) Cadmium 100 mM 48 hrs, 4-day adult  106 Copper 0.5 mM 12 hrs, larvae L3    64 Copper 15 mM 48 hrs, 4-day adult  (143) Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult  (111) Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3  (127) Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (112) Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    94 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3  (115) Rotenone 8 μg 12 hrs, larvae L3    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    55 cold shock, 4-day adult    48 heat shock, 4-day adult    89 Cadmium 50 mM 6 hrs, larvae L3    101 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    110 Cadmium 100 mM 48 hrs, 4-day adult    106 Copper 0.5 mM 12 hrs, larvae L3    64 Copper 15 mM 48 hrs, 4-day adult    143 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    111 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    127 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    94 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    91 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    55 cold shock, 4-day adult    48 heat shock, 4-day adult    89 Cadmium 50 mM 6 hrs, larvae L3    101 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    110 Cadmium 100 mM 48 hrs, 4-day adult    106 Copper 0.5 mM 12 hrs, larvae L3    64 Copper 15 mM 48 hrs, 4-day adult    143 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    111 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    127 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    94 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (55) cold shock, 4-day adult  (48) heat shock, 4-day adult  (89) Cadmium 50 mM 6 hrs, larvae L3  (101) Cadmium 50 mM 12 hrs, larvae L3  (114) Cadmium 50 mM 48 hrs, 4-day adult  (110) Cadmium 100 mM 48 hrs, 4-day adult  (106) Copper 0.5 mM 12 hrs, larvae L3  (64) Copper 15 mM 48 hrs, 4-day adult  (143) Zinc 5 mM 12 hrs, larvae L3  (84) Zinc 4.5 mM 48 hrs, 4-day adult  (111) Ethanol 2.5% 3 hrs, larvae L3  (74) Ethanol 5% 3 hrs, larvae L3  (127) Ethanol 10% 3 hrs, larvae L3  (96) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (88) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (112) Caffeine 25 mg/ml 48 hrs, 4-day adult  (77) Paraquat 5 mM 48 hrs, 4-day adult  (94) Paraquat 10 mM 48 hrs, 4-day adult  (64) Rotenone 2 μg 12 hrs, larvae L3  (115) Rotenone 8 μg 12 hrs, larvae L3  (91) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    55 cold shock, 4-day adult    48 heat shock, 4-day adult    89 Cadmium 50 mM 6 hrs, larvae L3  101 Cadmium 50 mM 12 hrs, larvae L3  114 Cadmium 50 mM 48 hrs, 4-day adult  110 Cadmium 100 mM 48 hrs, 4-day adult  106 Copper 0.5 mM 12 hrs, larvae L3    64 Copper 15 mM 48 hrs, 4-day adult  143 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult  111 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3  127 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  112 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    94 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3  115 Rotenone 8 μg 12 hrs, larvae L3    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    55 cold shock, 4-day adult    48 heat shock, 4-day adult    89 Cadmium 50 mM 6 hrs, larvae L3    101 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    110 Cadmium 100 mM 48 hrs, 4-day adult    106 Copper 0.5 mM 12 hrs, larvae L3    64 Copper 15 mM 48 hrs, 4-day adult    143 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    111 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    127 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    94 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RE62265 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019925 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6202-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Surf4 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Surf4CC01684 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Surf4GD2999 viable Surf4EY13994 Sterility Allele fertile Surf4EY13994 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Surf4GD2999 visible, with Scer\GAL4pnr-MD237 Surf4GD2999 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 Surf4GD2999 mesothoracic tergum, with Scer\GAL4pnr-MD237 Surf4GD2999
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Surf4 Class Mutagen Stocks Known lesion Surf4d04274 P-element activity 2 -- Surf4EY13994 P-element activity 1 -- Surf4CC01684 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Surf4 Class Mutagen Stocks Known lesion Surf4GD2999 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Surf4KK101986 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Surf4NIG.6202R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6174 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2999} NA P{KK101986} NA P{NIG.6202R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Surf4EY13994 NA P{GSV1}EP-158EP-158 NA P{XP}Surf4d04274 NA miscellaneous insertions P{PTT-GC}Surf4CC01684 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009)
Cellular Component
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane inferred from sequence or structural similarity (Swiss-Prot Project Members, 2001.8.20) inferred from sequence or structural similarity with UniProtKB:O15260 (FlyBase, 1992-) integral to membrane inferred from electronic annotation with InterPro:IPR002995 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Surf4 - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG11857 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG12262 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG13220 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG13887 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG1444 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG15087 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG15098 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG15211 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG18173 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG2064 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG2070 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG30008 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG30344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG3164 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG31729 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG3526 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG3558 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG5447 experimental knowledge based (Guruharsha et al., 2011) Surf4 - CG7655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG8026 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG8195 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Surf4 - CG8602 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Ca-P60A experimental knowledge based (Guruharsha et al., 2011) Surf4 - CdsA experimental knowledge based (Guruharsha et al., 2011) Surf4 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Cyp4ad1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Esp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - IntS10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - KdelR experimental knowledge based (Guruharsha et al., 2011) Surf4 - Kr-h2 experimental knowledge based (Guruharsha et al., 2011) Surf4 - MRP experimental knowledge based (Guruharsha et al., 2011) Surf4 - Mec2 experimental knowledge based (Guruharsha et al., 2011) Surf4 - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Oamb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Ost48 experimental knowledge based (Guruharsha et al., 2011) Surf4 - OstΔ experimental knowledge based (Guruharsha et al., 2011) Surf4 - Ostγ experimental knowledge based (Guruharsha et al., 2011) Surf4 - PH4αSG1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Pis anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Rcd6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - Sc2 experimental knowledge based (Guruharsha et al., 2011) Surf4 - Sec61α experimental knowledge based (Guruharsha et al., 2011) Surf4 - Tango9 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Surf4 - Tapδ experimental knowledge based (Guruharsha et al., 2011) Surf4 - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - ZnT63C experimental knowledge based (Guruharsha et al., 2011) Surf4 - fax experimental knowledge based (Guruharsha et al., 2011) Surf4 - ine anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - jagn experimental knowledge based (Guruharsha et al., 2011) Surf4 - pigeon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - porin experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Surf4 - schlank anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - sip3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Surf4 - sun experimental knowledge based (Guruharsha et al., 2011) Surf4 - wls anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Surf4 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66927 DroID - A comprehensive database of gene and protein interactions. • FBgn0019925 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41864
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SN27Z Dipteran inclusive ortholog search EOG65QHP5 Insect inclusive ortholog search EOG6000F8 Arthropod inclusive ortholog search EOG695X7T Metazoa inclusive ortholog search EOG6B620G
Orthologs in Drosophila Species (EOG6SN27Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Surf4     Drosophila simulans   Dsim\GD20359 Y   Drosophila sechellia   Dsec\GM25782 Y   Drosophila erecta   Dere\GG20651 Y   Drosophila yakuba   Dyak\GE26387 Y   Drosophila ananassae   Dana\GF23237 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19436 Y   Drosophila persimilis   Dper\GL13757 Y   Drosophila willistoni   Dwil\GK11312 Y   Drosophila virilis   Dvir\GJ10672 Y   Drosophila mojavensis   Dmoj\GI10730 Y   Drosophila grimshawi   Dgri\GH16895 Y
Orthologs in non-Drosophila Dipterans (EOG65QHP5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008461   Anopheles gambiae Malaria mosquito  Agam\AGAP001069   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011515   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011516
Orthologs in non-Dipteran Insects (EOG6000F8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Surf4   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003698   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20280   Atta cephalotes Leafcutter ant  Acep\ACEP23817   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17903   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23708   Linepithema humile Argentine ant  Lhum\LH13726   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18553   Solenopsis invicta Red fire ant  Sinv\SINV15461   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004461   Bombyx mori Silkmoth  Bmor\BGIBMGA007639   Pediculus humanus Human body louse  Phum\PHUM212820   Tribolium castaneum Red flour beetle  Tcas\TC000161
Orthologs in non-Insect Arthropods (EOG695X7T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307341   Ixodes scapularis Deer tick  Isca\ISCW010081
Orthologs in non-Arthropod Metazoa (EOG6B620G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\sft-4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006044gn   Danio rerio Zebrafish  Drer\surf4l   Danio rerio Zebrafish  Drer\surf4   Xenopus tropicalis Western clawed frog  Xtro\surf4   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000003448   Xenopus tropicalis Western clawed frog  Xtro\surf4.2   Gallus gallus Domestic chicken  Ggal\SURF4   Mus musculus House mouse  Mmus\Surf4   Homo sapiens Human  Hsap\SURF4
Human Orthologs (1)
Gene OMIM HGNC Hsap\SURF4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20359 Drosophila sechellia Dsec\GM25782 Drosophila erecta Dere\GG20651 Drosophila yakuba Dyak\GE26387 Drosophila ananassae Dana\GF23237 Drosophila pseudoobscura pseudoobscura Dpse\GA19436 Drosophila persimilis Dper\GL13757 Drosophila willistoni Dwil\GK11312 Drosophila virilis Dvir\GJ10672 Drosophila mojavensis Dmoj\GI10730 Drosophila grimshawi Dgri\GH16895
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20787 y1 w67c23; P{EPgy2}Surf4EY13994 19202 w1118; P{XP}Surf4d04274/TM6B, Tb1
Harvard	- P{XP}Surf4d04274
VDRC	v5883 w1118 P{GD2999}v5883
Genomic Clones ( 2 )
	BACR13A02 BACR17K19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 307 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE62265
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08267 AT23794 GH10104 GH18340 GH19328 GH21202 GM06147 GM17696 LD14260 LD15628 LP04064 RE02318 RE04364 RE05510 RE19176 RE20382 RE22892 RE26434 RE31231 RE31893 RE36189 RE37247 RE39053 RE45602 RE45770 RE47875 RE48691 RE51491 RE66378 RE74633 RH01763 RH03474 RH09888 RH55275 RH57093 RH65842 RH71076 RH71845 RH72653 RH72663
Other clones	5276 8972 9356 20800 166919 214543.32 528309 557949 CK01.18D.H11 CK01.126A.H11 Dmel_dig_016569_0674_2859 Dmel_neb_012467_0822_2320 EC051888 EC051966 EC052391 EC052468 EC052960 EC053459 EC053469 EC053952 EC054924 EK096532 EK107930 EK108530 EK117002 EK123964 EK134319 EK171003 EN09435 EN12717 EP16242 ESG013c.E21_H03 FGM209D02 FGM216A05 FGM318D03 IP14339 RE01959 RP003008991 RP003013355 RP003020760 RP003023665 RP003023695 RP003036192 RP003042612 RP003046983 RP003056500 RP003060029 RP003069910 RP003070075 RP003073329 RP003079140 RP003079295 RP003080231 RP003081709 RP003082728 RP003091214 RP003092634 RP003093909 RP003098180 RP003102539 RP003107250 RP003108684 RP003112863 RP003117951 RP003118499 RP003121125 RP003123106 RP003124399 RP003127247 RP003127991 RP003128481 RP003136825 RP003138876 RP003146240 RP003147531 RP003148593 RP003151086 RP003155766 RP003156976 RP003158150 RP003159385 RP003160990 RP003163159 RP003164633 RP003165214 RP003168375 RP003168934 RP003171887 RP003172406 RP003176340 RP003178117 RP003179725 RP003182033 RP003184949 RP003185241 RP003187226 RP003187653 RP003192795 RP003195719 RP003197144 RP003198406 RP003199331 RP003203805 RP003207090 RP003209152 RP003209213 RP003209231 RP003214186 RP003219678 RP003226524 RP003232047 RP003236043 RP003236659 RP003238570 RP003238894 RP003240149 RP003241361 RP003242973 RP003246774 RP003247187 RP003247223 RP003247358 RP003250808 RP003255457 RP003256616 RP003256690 RP003258749 RP003260952 RP003263118 RP003263719 RP003265561 RP003265710 RP003266826 RP003267200 RP003267634 RP003269873 RP003270229 RP003272000 RP003272475 RP003274507 RP003276107 RP003277224 RP003281379 RP003282524 RP003283842 RP003285703 RP003286268 RP003286402 RP003286966 RP003287666 RP003289510 RP003290608 RP003293056 RP003293139 RP003295095 RP003300413 RP003302869 RP003303135 RP003303605 RP003307845 RP003308626 RP003310110 RP003311737 RP003313058 RP003313481 RP003321270 RP003322210 RP003323188 RP003324310 RP003324498 RP003325761 RP003327214 RP003329686 RP003329765 RP003331033 RP003331672 RP003332595 RP003334200 RP003337345 RP003340007 RP003342890 RP003343493 RP003345488 RP003346024 RP003352470 RP003353183 RP003358305 RP003359173 RP003364479 RP003366770 RP003366973 RP003389376 RP003393965 RP003395790 RP003396922 RP003398735 RP003400259 RP003400567 RP003403803 RP003405975 RP003411730 RP003413579 RP003416863 RP003420581 RP003427540 RP003433693 RP003436594 RP003441337 RP003451876 RP003462540 RP003468551 RP003468876 RP003469390 RP003475143 RP003476652 RP003480613 RP003481163 RP003487722 RP003489150 RP003490330 RP003490907 RP003496057 RP003496130 RP003497035 RP003497534 RP003501740 RP003510045 RP003510662 RP003515652 RP003515970 RP003520563 RP003527839 RP003537129 RP003539187 RP003540409 RP003569474 RP003570537 RP003572973 RP003574673 RP003575510 RP003575843 RP003584766 RP003585045 RP003585274 RP003586827 RP003589483 RP003590153 RP003593775 RP003598117 RP003601341 RP003606533 RP003626642 RP003631504 RP003631711 RP003632242 RP003635307 RP003640428 RP003643781 RP003645200 RP003647024 RP003647132 RP003647355 RP003647800 RP003647838 RP003648308 RP003675240
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0019925 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41864
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Surf4 CG6202 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	In mouse the Surfeit locus contains six Surf genes in a tight gene cluster. In Drosophila Surf4 is not closely associated with other Surfeit gene homologs. (Armes and Fried, 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057874 NM_169647 RefSeq (Proteins) • NP_477222 NP_732016 DDBJ / EMBL / GenBank • AAF55176 AAM48435 AAN13656 AY118406 BI374628 CAA75100 CL868609 CZ473828 Y14823 Entrez Gene - A searchable database of RefSeq genes. • 41864 UniProtKB/Swiss-Prot • O18405
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Surfeit locus 4 (IPR002995) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE62265
Linkouts
	BioGRID - A database of protein and genetic interactions • 66927 DroID - A comprehensive database of gene and protein interactions. • FBgn0019925 DRSC - Results from RNAi screens. • FBgn0019925 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019925 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6202-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0019925 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41864 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41864 modMine - Data generated by the modENCODE project. • FBgn0019925
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG6202 (Molnar et al., 2006, Keleman et al., 2009.8.5) Surf4 (Czech et al., 2008, Buszczak et al., 2007, Molnar et al., 2006, Hazelett et al., 2012, Vinci et al., 2008, Lighthouse et al., 2008, Japanese National Institute of Genetics, 2012.5.21) SURF-4 (Fried, 1997.9.15) Surf-4 (Armes and Fried, 1996)
Name Synonym	Surfeit 4 (Armes and Fried, 1996, Tan et al., 2009)
Secondary FlyBase IDs
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Show all research papers ...