FlyBase Gene Report: Dmel\Ser7

General Information

Symbol

Dmel\Ser7

Species

D. melanogaster

Name

Ser7

Annotation Symbol

CG2045

Feature Type

protein_coding_gene

FlyBase ID

FBgn0019929

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SP#2

Key Links

Genomic Location

Cytogenetic map

9A2-9A2

Sequence location

X:9,865,233..9,867,070 [+]

Recombination map

1-30

RefSeq locus

NC_004354 REGION:9865233..9867070

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from sequence model

(Cao and Jiang, 2018, Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

enables serine-type peptidase activity

inferred from sequence or structural similarity

(Coustau et al., 1996)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE -: Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ser7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W314)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ser7-RA

FBtr0071387

NM_132354

1413

397

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ser7-PA

FBpp0071322

43.6

397

7.35

Q9W314

NP_572582

AAF46523

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W314

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ser7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ser7_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ser7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ser7

View exonic expression by tissue for Dmel\Ser7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0019929

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31917/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0019929

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0019929

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0019929

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2045

Flygut - An atlas of the Drosophila adult midgut

FBgn0019929

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ser7

Transgenic constructs containing regulatory region of Ser7

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ser7^GD6459

viable, with Scer\GAL4^Mef2.PR

Ser7^GD6459

viable, with Scer\GAL4^pnr-MD237

Ser7^GD6459

viable, with Scer\GAL4^unspecified

Ser7^RNAi.UAS.cMa

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (99)

Hsap\F10

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\HPN

1 of 14

Hsap\HPR

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (88)

Rnor\F10

2 of 14

Yes

Rnor\Acr

1 of 14

Rnor\C1s

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (109)

Mmus\1810009J06Rik

1 of 14

Yes

Mmus\2210010C04Rik

1 of 14

Yes

Mmus\Acr

1 of 14

Yes

Mmus\C1s1

1 of 14

Yes

Mmus\Cela2a

1 of 14

Yes

Mmus\Cela3b

1 of 14

Yes

Mmus\Cfd

1 of 14

Yes

Mmus\Cfi

1 of 14

Yes

Mmus\Cma2

1 of 14

Yes

Mmus\Ctrb1

1 of 14

Yes

Mmus\Ctrc

1 of 14

Yes

Mmus\Ctrl

1 of 14

Yes

Mmus\Ctsg

1 of 14

Yes

Mmus\Egfbp2

1 of 14

Yes

Mmus\Elane

1 of 14

Yes

Mmus\F2

1 of 14

Yes

Mmus\F7

1 of 14

Yes

Mmus\F9

1 of 14

Yes

Mmus\F10

1 of 14

Yes

Mmus\F11

1 of 14

Yes

Mmus\F12

1 of 14

Yes

Mmus\Gm2663

1 of 14

Yes

Mmus\Gm5771

1 of 14

Yes

Mmus\Gm10334

1 of 14

Yes

Mmus\Gzma

1 of 14

Yes

Mmus\Gzmc

1 of 14

Yes

Mmus\Gzme

1 of 14

Yes

Mmus\Gzmf

1 of 14

Yes

Mmus\Gzmg

1 of 14

Yes

Mmus\Gzmm

1 of 14

Yes

Mmus\Gzmn

1 of 14

Yes

Mmus\Habp2

1 of 14

Yes

Mmus\Hgfac

1 of 14

Yes

Mmus\Hpn

1 of 14

Yes

Mmus\Klk1b1

1 of 14

Yes

Mmus\Klk1b3

1 of 14

Yes

Mmus\Klk1b5

1 of 14

Yes

Mmus\Klk1b8

1 of 14

Yes

Mmus\Klk1b9

1 of 14

Yes

Mmus\Klk1b11

1 of 14

Yes

Mmus\Klk1b26

1 of 14

Yes

Mmus\Klk1

1 of 14

Yes

Mmus\Klk4

1 of 14

Yes

Mmus\Klk5

1 of 14

Yes

Mmus\Klk6

1 of 14

Yes

Mmus\Klk8

1 of 14

Yes

Mmus\Klk10

1 of 14

Yes

Mmus\Klk11

1 of 14

Yes

Mmus\Klk12

1 of 14

Yes

Mmus\Klk13

1 of 14

Yes

Mmus\Klk14

1 of 14

Yes

Mmus\Klk15

1 of 14

Yes

Mmus\Klkb1

1 of 14

Yes

Mmus\Masp1

1 of 14

Yes

Mmus\Masp2

1 of 14

Yes

Mmus\Mcpt1

1 of 14

Yes

Mmus\Mcpt4

1 of 14

Yes

Mmus\Mcpt8

1 of 14

Yes

Mmus\Ovch2

1 of 14

Yes

Mmus\Plat

1 of 14

Yes

Mmus\Plau

1 of 14

Yes

Mmus\Plg

1 of 14

Yes

Mmus\Proc

1 of 14

Yes

Mmus\Prss1

1 of 14

Yes

Mmus\Prss2

1 of 14

Yes

Mmus\Prss3

1 of 14

Yes

Mmus\Prss8

1 of 14

Yes

Mmus\Prss12

1 of 14

Yes

Mmus\Prss21

1 of 14

Yes

Mmus\Prss22

1 of 14

Yes

Mmus\Prss27

1 of 14

Yes

Mmus\Prss29

1 of 14

Yes

Mmus\Prss30

1 of 14

Yes

Mmus\Prss32

1 of 14

Yes

Mmus\Prss34

1 of 14

Yes

Mmus\Prss39

1 of 14

Yes

Mmus\Prss41

1 of 14

Yes

Mmus\Prss42

1 of 14

Yes

Mmus\Prss43

1 of 14

Yes

Mmus\Prss44

1 of 14

Yes

Mmus\Prss45

1 of 14

Yes

Mmus\Prss46

1 of 14

Yes

Mmus\Prss47

1 of 14

Yes

Mmus\Prss48

1 of 14

Yes

Mmus\Prss55

1 of 14

Yes

Mmus\Prss56

1 of 14

Yes

Mmus\Prss57

1 of 14

Yes

Mmus\Prtn3

1 of 14

Yes

Mmus\St14

1 of 14

Yes

Mmus\Tmprss2

1 of 14

Yes

Mmus\Tmprss3

1 of 14

Yes

Mmus\Tmprss4

1 of 14

Yes

Mmus\Tmprss5

1 of 14

Yes

Mmus\Tmprss6

1 of 14

Yes

Mmus\Tmprss9

1 of 14

Yes

Mmus\Tmprss11a

1 of 14

Yes

Mmus\Tmprss11b

1 of 14

Yes

Mmus\Tmprss11d

1 of 14

Yes

Mmus\Tmprss11f

1 of 14

Yes

Mmus\Tmprss11g

1 of 14

Yes

Mmus\Tmprss12

1 of 14

Yes

Mmus\Tmprss13

1 of 14

Yes

Mmus\Tmprss15

1 of 14

Yes

Mmus\Tpsab1

1 of 14

Yes

Mmus\Tpsb2

1 of 14

Yes

Mmus\Tpsg1

1 of 14

Yes

Mmus\Try4

1 of 14

Yes

Mmus\Try5

1 of 14

Yes

Mmus\Try10

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (59)

Xtro\c1s

2 of 13

Yes

Xtro\proc.2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (75)

Drer\f10

2 of 14

Yes

Drer\LOC100004411

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:dkey-78l4.4

1 of 14

Drer\si:dkey-78l4.10

1 of 14

Drer\si:dkey-78l4.11

1 of 14

Yes

Drer\si:dkey-78l4.12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\nas-39

1 of 14

Yes

Cele\svh-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (253)

Agam\CLIPB5

3 of 12

Yes

Agam\CLIPB6

3 of 12

Yes

Agam\CLIPB8

3 of 12

Yes

Agam\CLIPB13

3 of 12

Yes

Agam\CLIPB36

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004639

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011430

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012946

1 of 12

Agam\AgaP_AGAP013020

1 of 12

Agam\AgaP_AGAP013117

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ser7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (196)

SPE

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

MP1

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

mas

3 of 13

Sp7

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

teq

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ser7 - Hayan

enzymatic study, anti tag western blot

(Shan et al., 2023)

Ser7 - PPO2

enzymatic study, western blot

(Shan et al., 2023)

Ser7 - boca

experimental knowledge based

(Guruharsha et al., 2011)

Ser7 - psh

enzymatic study, anti tag western blot

(Shan et al., 2023)

Ser7 - spz

enzymatic study, western blot

(Shan et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58354

DroID - A comprehensive database of gene and protein interactions.

FBgn0019929

MIST (protein-protein) - An integrated Molecular Interaction Database

31917

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-30

Cytogenetic map

9A2-9A2

Sequence location

X:9,865,233..9,867,070 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

9A2-9A2

Limits computationally determined from genome sequence between P{EP}nej^EP1149&P{EP}nej^EP1179 and P{EP}α-Man-I^EP1628&P{EP}α-Man-I^EP1307

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-30

(FlyBase, 2016)

1-31.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41622

y¹ v¹; P{TRiP.GL01204}attP40

80590

y¹ TI{CRIMIC.TG4.0}Ser7^{CR00538-TG4.0} w^*

42649

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02485}attP2

VDRC

v44072

w¹¹¹⁸; P{GD6459}v44072

v44074

w¹¹¹⁸; P{GD6459}v44074/TM3

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (20)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH14088

Other clones

DPiM_GH14088

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0019929

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0019929

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: as a degenerate PCR amplified fragment.

(Coustau et al., 1996)

Expression of Ser7 transcript increases in larvae challenged with bacteria or parasitic wasp eggs.

(Coustau et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: Ser7 CG2045

(Schlenke, 2001.10.30, FlyBase, 1996-)

Additional comments

Source for merge of Ser7 CG2045 was sequence comparison ( date:011031 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG2045

(Veillard et al., 2016, Nam et al., 2012, Ni et al., 2010.12.1, Shah et al., 2008, Mulinari et al., 2006, Ross et al., 2003, Irving et al., 2001)

SP#2

(Coustau et al., 1996)

SP2

SP3

(Ross et al., 2003)

Ser7

(Owings and Chow, 2024, Nakano et al., 2023, Kumar et al., 2021, Cao and Jiang, 2018, Levis, 2018.8.30, Veillard et al., 2016, Keebaugh and Schlenke, 2014, Japanese National Institute of Genetics, 2012.5.21, Napoletano et al., 2011, Hill-Burns and Clark, 2009, Zsindely et al., 2009, Shah et al., 2008, Busse et al., 2007, Christophides et al., 2002)

c-SP3

(Ross et al., 2003)

cSP3

(Cao and Jiang, 2018)

Name Synonyms

Ser7

Serine Protease 2

Secondary FlyBase IDs

FBgn0030154

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31917

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W314

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W314

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W314

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0019929

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31917/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0019929

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0019929

FlyMine - An integrated database for Drosophila genomics

FBgn0019929

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2045

MARRVEL_MODEL - MARRVEL (model organism gene)

31917

Linkouts

BioGRID - A database of protein and genetic interactions.

58354

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0019929

DroID - A comprehensive database of gene and protein interactions.

FBgn0019929

DRSC - Results frm RNAi screens

FBgn0019929

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ser7_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0019929

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0019929

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2045

Flygut - An atlas of the Drosophila adult midgut

FBgn0019929

MIST (protein-protein) - An integrated Molecular Interaction Database

31917

References (42)

The following external sites may use different assemblies or annotations than FlyBase.

-0.75

Report Sections