FlyBase Gene Report: Dmel\Orct

SLC22 FAMILY OF ORGANIC IONS TRANSPORTERS -: Solute carrier family 22 (SLC22) members are organic cation, organic anion and organic zwiterrion/cations transporters. (Adapted from FBrf0179202 and PMID:23506881).

Protein Function (UniProtKB)

Probably transports organic cations.

(UniProt, Q9VCA2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Orct or the JBrowse view of Dmel\Orct for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Possible gene duplication of CG13610

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Orct-RA

FBtr0084599

NM_079755

2533

548

Orct-RB

FBtr0334870

NM_001275979

2154

548

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Orct-PA

FBpp0083983

61.0

548

5.56

NP_524479

AAF56271

Orct-PB

FBpp0306893

61.0

548

5.56

NP_001262908

AGB96288

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

548 aa isoforms: Orct-PA, Orct-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

548, 370 (aa)

(Taylor et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orct using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

transmembrane transporter activity

inferred from electronic annotation with InterPro:IPR005828

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

apoptotic process

traceable author statement

(assigned by UniProt )

(Taylor et al., 1997)

transmembrane transport

inferred from electronic annotation with InterPro:IPR005828

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

integral component of membrane

inferred from electronic annotation with InterPro:IPR005828

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

non-traceable author statement

(assigned by UniProt )

(Taylor et al., 1997)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 12

midline primordium

(Kearney et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic midgut chamber

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval midgut interstitial cell

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & larval stage & adult stage

(Taylor et al., 1997)

Additional Descriptive Data

Orct transcripts are detected in embryos, third instar larvae, and adults on northern blots with the highest levels in larvae. Other stages were not tested.

(Taylor et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{PZ}lmgA⁰³⁴²⁴

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

stomodeum