FB2020_06, released Dec 22, 2020

Gene: Dmel\Orct

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General Information
Symbol
Dmel\Orct
Species
D. melanogaster
Name
Organic cation transporter
Annotation Symbol
CG6331
Feature Type
protein_coding_gene
FlyBase ID
FBgn0019952
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
95F8-95F8
Sequence location
3R:24,276,260..24,278,792 [+]
Recombination map

3-84

RefSeq locus
NT_033777 REGION:24276260..24278792
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables transmembrane transporter activity
inferred from electronic annotation with InterPro:IPR005828
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in apoptotic process
traceable author statement
(assigned by UniProt )
(Taylor et al., 1997)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR005828
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR005828
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
non-traceable author statement
(assigned by UniProt )
(Taylor et al., 1997)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (Q9VCA2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC22 FAMILY OF ORGANIC IONS TRANSPORTERS -
Solute carrier family 22 (SLC22) members are organic cation, organic anion and organic zwiterrion/cations transporters. (Adapted from FBrf0179202 and PMID:23506881).
Protein Function (UniProtKB)
Probably transports organic cations.
(UniProt, Q9VCA2)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Orct for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Possible gene duplication of CG13610

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Orct-RA
FBtr0084599
NM_079755
2533
548
Orct-RB
FBtr0334870
NM_001275979
2154
548
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Orct-PA
FBpp0083983
61.0
548
5.56
NP_524479
AAF56271
Orct-PB
FBpp0306893
61.0
548
5.56
NP_001262908
AGB96288
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

548 aa isoforms: Orct-PA, Orct-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

548, 370 (aa)

(Taylor et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orct using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 12
midline primordium
(Kearney et al., 2004)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic midgut chamber
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
(Taylor et al., 1997)
Additional Descriptive Data

Orct transcripts are detected in embryos, third instar larvae, and adults on northern blots with the highest levels in larvae. Other stages were not tested.

(Taylor et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Orct in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Orct
Transgenic constructs containing regulatory region of Orct
Deletions and Duplications ( 5 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC22A4
8 of 15
Yes
Yes
Hsap\SLC22A5
7 of 15
No
Yes
Hsap\SLC22A13
7 of 15
No
Yes
Hsap\SLC22A16
7 of 15
No
Yes
Hsap\SLC22A6
6 of 15
No
Yes
Hsap\SLC22A12
6 of 15
No
Yes
Hsap\SLC22A1
5 of 15
No
Yes
Hsap\SLC22A2
5 of 15
No
Yes
1  
Hsap\SLC22A3
5 of 15
No
No
Hsap\SLC22A8
5 of 15
No
Yes
Hsap\SLC22A11
5 of 15
No
No
Hsap\SLC22A7
4 of 15
No
No
Hsap\SLC22A9
4 of 15
No
Yes
Hsap\SLC22A10
4 of 15
No
Yes
Hsap\SLC22A14
4 of 15
No
No
Hsap\SLC22A15
4 of 15
No
Yes
Hsap\SLC22A25
4 of 15
No
No
Hsap\SLC22A17
3 of 15
No
Yes
Hsap\SLC22A23
3 of 15
No
Yes
Hsap\SLC22A24
3 of 15
No
No
Hsap\SLC22A31
3 of 15
No
Yes
Hsap\SVOP
3 of 15
No
No
Hsap\SV2A
2 of 15
No
No
Hsap\SV2B
2 of 15
No
No
Hsap\SV2C
2 of 15
No
No
Hsap\SLC22A20P
1 of 15
No
No
Hsap\SVOPL
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (30)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc22a4
8 of 15
Yes
Yes
Mmus\Slc22a21
8 of 15
Yes
Yes
Mmus\Slc22a5
7 of 15
No
Yes
Mmus\Slc22a1
6 of 15
No
Yes
Mmus\Slc22a2
6 of 15
No
Yes
Mmus\Slc22a3
6 of 15
No
Yes
Mmus\Slc22a6
6 of 15
No
Yes
Mmus\Slc22a12
6 of 15
No
Yes
Mmus\Slc22a13
6 of 15
No
No
Mmus\Slc22a16
6 of 15
No
No
Mmus\Slc22a8
5 of 15
No
Yes
Mmus\Slc22a20
5 of 15
No
Yes
Mmus\Slc22a7
4 of 15
No
No
Mmus\Slc22a14
4 of 15
No
No
Mmus\Slc22a19
4 of 15
No
Yes
Mmus\Slc22a22
4 of 15
No
No
Mmus\Slc22a26
4 of 15
No
Yes
Mmus\Slc22a27
4 of 15
No
No
Mmus\Slc22a28
4 of 15
No
No
Mmus\Slc22a29
4 of 15
No
Yes
Mmus\Slc22a30
4 of 15
No
Yes
Mmus\Slc22a15
3 of 15
No
Yes
Mmus\Slc22a17
3 of 15
No
No
Mmus\Slc22a23
3 of 15
No
Yes
Mmus\Svop
3 of 15
No
No
Mmus\Sv2a
2 of 15
No
No
Mmus\Sv2b
2 of 15
No
No
Mmus\Sv2c
2 of 15
No
No
Mmus\Slc22a13b
1 of 15
No
Yes
Mmus\Svopl
1 of 15
No
No
Rattus norvegicus (Norway rat) (28)
Rnor\Slc22a1
7 of 13
Yes
Yes
Rnor\Slc22a2
7 of 13
Yes
Yes
Rnor\Slc22a3
7 of 13
Yes
Yes
Rnor\Slc22a5
5 of 13
No
Yes
Rnor\Slc22a6
5 of 13
No
Yes
Rnor\LOC685081
4 of 13
No
No
Rnor\Slc22a8
4 of 13
No
No
Rnor\Slc22a12
4 of 13
No
Yes
Rnor\Slc22a13
4 of 13
No
Yes
Rnor\Slc22a15
4 of 13
No
Yes
Rnor\Slc22a20
4 of 13
No
No
Rnor\Slc22a22
4 of 13
No
No
Rnor\Slc22a25
4 of 13
No
No
Rnor\UST4r
4 of 13
No
No
Rnor\Slc22a7
3 of 13
No
No
Rnor\Slc22a17
3 of 13
No
No
Rnor\Slc22a23
3 of 13
No
Yes
Rnor\Ust5r
3 of 13
No
Yes
Rnor\LOC303140
2 of 13
No
Yes
Rnor\Slc22a4
2 of 13
No
No
Rnor\Slc22a14
2 of 13
No
No
Rnor\Slc22a16
2 of 13
No
Yes
Rnor\Svop
2 of 13
No
No
Rnor\LOC102553250
1 of 13
No
No
Rnor\Slc22a24
1 of 13
No
No
Rnor\Sv2a
1 of 13
No
No
Rnor\Sv2c
1 of 13
No
No
Rnor\Svopl
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\slc22a6
7 of 12
Yes
Yes
Xtro\slc22a5
6 of 12
No
Yes
Xtro\slc22a16
5 of 12
No
Yes
Xtro\slc22a4
4 of 12
No
Yes
Xtro\slc22a13
4 of 12
No
No
Xtro\slc22a15.1
4 of 12
No
Yes
Xtro\slc22a15.2
4 of 12
No
Yes
Xtro\slc22a31
3 of 12
No
Yes
Xtro\LOC100490266
2 of 12
No
Yes
Xtro\LOC100490946
2 of 12
No
Yes
Xtro\slc22a2
2 of 12
No
Yes
Xtro\slc22a8l.1
2 of 12
No
No
Xtro\slc22a20p.1
2 of 12
No
Yes
Xtro\sv2b
2 of 12
No
No
Xtro\svop
2 of 12
No
No
Xtro\sv2a
1 of 12
No
No
Xtro\sv2c
1 of 12
No
No
Xtro\svopl
1 of 12
No
No
Danio rerio (Zebrafish) (32)
Drer\si:dkey-166k12.1
9 of 15
Yes
Yes
Drer\slc22a13b
8 of 15
No
Yes
Drer\si:dkey-119m7.4
6 of 15
No
Yes
Drer\slc22a6l
6 of 15
No
Yes
Drer\slc22a16
6 of 15
No
Yes
Drer\oct2
5 of 15
No
Yes
Drer\slc22a2
5 of 15
No
Yes
Drer\slc22a4
5 of 15
No
Yes
Drer\slc22a5
5 of 15
No
Yes
Drer\oatx
4 of 15
No
No
Drer\slc22a7a
4 of 15
No
No
Drer\slc22a7b.1
4 of 15
No
No
Drer\slc22a15
4 of 15
No
Yes
Drer\slc22a21
4 of 15
No
No
Drer\slc22a23
4 of 15
No
Yes
Drer\LOC566640
3 of 15
No
No
Drer\slc22a7b.2
3 of 15
No
No
Drer\slc22a7b.3
3 of 15
No
No
Drer\slc22a13a
3 of 15
No
No
Drer\slc22a31
3 of 15
No
Yes
Drer\zmp:0000001102
3 of 15
No
No
Drer\sv2a
2 of 15
No
No
Drer\sv2bb
2 of 15
No
No
Drer\sv2ca
2 of 15
No
No
Drer\svopa
2 of 15
No
No
Drer\LOC100334012
1 of 15
No
No
Drer\LOC101884074
1 of 15
No
No
Drer\slc22a17
1 of 15
No
Yes
Drer\sv2ba
1 of 15
No
No
Drer\sv2
1 of 15
No
No
Drer\svopb
1 of 15
No
No
Drer\svopl
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (32)
Cele\Y82E9BR.16
8 of 15
Yes
Yes
Cele\F45E10.2
7 of 15
No
Yes
Cele\oct-1
6 of 15
No
No
Cele\oct-2
4 of 15
No
No
Cele\str-176
4 of 15
No
Yes
Cele\T05A1.5
4 of 15
No
No
Cele\T22F7.1
4 of 15
No
Yes
Cele\B0252.3
3 of 15
No
Yes
Cele\B0361.11
3 of 15
No
Yes
Cele\C06H5.6
3 of 15
No
Yes
Cele\C46C2.2
3 of 15
No
Yes
Cele\F17C11.12
3 of 15
No
No
Cele\F23F12.3
3 of 15
No
No
Cele\F23F12.13
3 of 15
No
No
Cele\F32H5.4
3 of 15
No
No
Cele\K05F1.6
3 of 15
No
No
Cele\oat-1
3 of 15
No
Yes
Cele\Y51A2D.18
3 of 15
No
No
Cele\Y66D12A.13
3 of 15
No
No
Cele\ZK892.3
3 of 15
No
No
Cele\C44C10.3
2 of 15
No
No
Cele\C53B4.1
2 of 15
No
No
Cele\pes-23
2 of 15
No
No
Cele\svop-1
2 of 15
No
No
Cele\T08B1.1
2 of 15
No
No
Cele\T12B3.2
2 of 15
No
No
Cele\Y57G11C.23
2 of 15
No
No
Cele\K09C4.4
1 of 15
No
No
Cele\K09C4.5
1 of 15
No
No
Cele\K09E9.1
1 of 15
No
Yes
Cele\K11D9.3
1 of 15
No
No
Cele\ZK829.9
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\OCT4
8 of 9
Yes
Yes
Atha\OCT1
5 of 9
No
Yes
Atha\OCT3
5 of 9
No
Yes
Atha\OCT2
4 of 9
No
Yes
Atha\OCT5
3 of 9
No
Yes
Atha\OCT6
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (15)
Scer\PHO84
4 of 15
Yes
Yes
Scer\GIT1
2 of 15
No
No
Scer\AQR1
1 of 15
No
Yes
Scer\DTR1
1 of 15
No
Yes
Scer\FLR1
1 of 15
No
Yes
Scer\HOL1
1 of 15
No
Yes
Scer\HXT9
1 of 15
No
No
Scer\QDR1
1 of 15
No
No
Scer\QDR2
1 of 15
No
Yes
Scer\QDR3
1 of 15
No
Yes
Scer\TPO1
1 of 15
No
Yes
Scer\TPO2
1 of 15
No
Yes
Scer\TPO3
1 of 15
No
Yes
Scer\TPO4
1 of 15
No
Yes
Scer\YHK8
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPAPB1E7.08c
5 of 12
Yes
No
Spom\SPBC8E4.01c
1 of 12
No
No
Spom\SPBC1271.09
1 of 12
No
No
Spom\SPCC2H8.02
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905FO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD21083
Drosophila sechellia
Dsec\GM26581
Drosophila erecta
Dere\GG11272
Drosophila yakuba
Dyak\GE23464
Drosophila ananassae
Dana\GF16120
Drosophila pseudoobscura pseudoobscura
Dpse\GA19517
Drosophila persimilis
Dper\GL23362
Drosophila willistoni
Dwil\GK11735
Drosophila willistoni
Dwil\GK11736
Drosophila virilis
Dvir\GJ24209
Drosophila mojavensis
Dmoj\GI22094
Drosophila grimshawi
Dgri\GH14185
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150165 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010058
Musca domestica
House fly
Mdoa\17010059
Glossina morsitans
Tsetse fly
Gmor\GMOY004574
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11706
Mayetiola destructor
Hessian fly
Mdes\Mdes014427
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012443
Anopheles darlingi
American malaria mosquito
Adar\ADAC010383
Anopheles gambiae
Malaria mosquito
Agam\AGAP004309
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001657
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02HQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2348939252
Apis mellifera
Western honey bee
Amel\LOC412399
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19103
Bombus terrestris
Buff-tailed bumblebee
Bter\15213169
Linepithema humile
Argentine ant
Lhum\LH14192
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b33
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000828
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00193
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12340
Tribolium castaneum
Red flour beetle
Tcas\TC002947
Pediculus humanus
Human body louse
Phum\PHUM284880
Rhodnius prolixus
Kissing bug
Rpro\RPRC011131
Cimex lectularius
Bed bug
Clec\CLEC006090
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003152
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10598
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0408 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010845
Strigamia maritima
European centipede
Smar\SMAR014801
Strigamia maritima
European centipede
Smar\SMAR005893
Strigamia maritima
European centipede
Smar\SMAR005895
Strigamia maritima
European centipede
Smar\SMAR014678
Strigamia maritima
European centipede
Smar\SMAR014217
Strigamia maritima
European centipede
Smar\SMAR005892
Strigamia maritima
European centipede
Smar\SMAR011430
Strigamia maritima
European centipede
Smar\SMAR007650
Strigamia maritima
European centipede
Smar\SMAR005896
Strigamia maritima
European centipede
Smar\SMAR008573
Ixodes scapularis
Black-legged tick
Isca\ISCW023859
Ixodes scapularis
Black-legged tick
Isca\ISCW018253
Ixodes scapularis
Black-legged tick
Isca\ISCW018658
Ixodes scapularis
Black-legged tick
Isca\ISCW008146
Ixodes scapularis
Black-legged tick
Isca\ISCW007789
Ixodes scapularis
Black-legged tick
Isca\ISCW018657
Ixodes scapularis
Black-legged tick
Isca\ISCW022995
Ixodes scapularis
Black-legged tick
Isca\ISCW018768
Ixodes scapularis
Black-legged tick
Isca\ISCW018250
Ixodes scapularis
Black-legged tick
Isca\ISCW020957
Ixodes scapularis
Black-legged tick
Isca\ISCW002228
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68451.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64973.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78101.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65310.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67684.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70014.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78100.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79480.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62071.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73711.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65316.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78099.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65311.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63092.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68455.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70941.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur24g01510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g03687
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g00920
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g06990
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g02460
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g05771
Tetranychus urticae
Two-spotted spider mite
Turt\tetur184g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur192g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g01720
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g01690
Tetranychus urticae
Two-spotted spider mite
Turt\tetur24g01520
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302495
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310083
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312381
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60927
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_64502
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_99384
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_50627
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_332857
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_229532
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04NR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Orctl3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a13_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027643gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Orct_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a9_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a5L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a5_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a13_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027501gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a13_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Orct_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007102gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc22a3_6
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022021
Ciona intestinalis
Vase tunicate
Cint\LOC100183072
Ciona intestinalis
Vase tunicate
Cint\LOC100186620
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (39)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Orct2
9 of 10
Balat
6 of 10
CG4630
6 of 10
CG6126
6 of 10
CG6356
6 of 10
CG7458
6 of 10
CG8654
6 of 10
CG44098
6 of 10
SLC22A
6 of 10
CG4459
5 of 10
CG4462
5 of 10
CG4465
5 of 10
CG5592
5 of 10
CG6006
5 of 10
CG6231
5 of 10
CG7333
5 of 10
CG7342
5 of 10
CG8925
5 of 10
CG10486
5 of 10
CG14855
5 of 10
CG14856
5 of 10
CG14857
5 of 10
CG16727
5 of 10
CG17751
5 of 10
CG17752
5 of 10
CG42269
5 of 10
CarT
4 of 10
CG3168
4 of 10
CG3690
4 of 10
CG4324
4 of 10
CG7084
4 of 10
CG12783
4 of 10
CG14691
4 of 10
CG15221
4 of 10
CG31103
4 of 10
CG31106
4 of 10
CG31272
4 of 10
CG33233
4 of 10
CG33234
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC22A4; solute carrier family 22 member 4
    8 of 15
    604190
    SLC22A5; solute carrier family 22 member 5
    7 of 15
    603377
    SLC22A13; solute carrier family 22 member 13
    7 of 15
    604047
        SLC22A16; solute carrier family 22 member 16
        7 of 15
        608276
            SLC22A6; solute carrier family 22 member 6
            6 of 15
            607582
                SLC22A12; solute carrier family 22 member 12
                6 of 15
                607096
                  SLC22A1; solute carrier family 22 member 1
                  5 of 15
                  602607
                      SLC22A2; solute carrier family 22 member 2
                      5 of 15
                      602608
                           
                          SLC22A3; solute carrier family 22 member 3
                          5 of 15
                          604842
                              SLC22A8; solute carrier family 22 member 8
                              5 of 15
                              607581
                                  SLC22A11; solute carrier family 22 member 11
                                  5 of 15
                                  607097
                                      SLC22A7; solute carrier family 22 member 7
                                      4 of 15
                                      604995
                                          SLC22A9; solute carrier family 22 member 9
                                          4 of 15
                                          607579
                                              SLC22A10; solute carrier family 22 member 10
                                              4 of 15
                                              607580
                                                  SLC22A14; solute carrier family 22 member 14
                                                  4 of 15
                                                  604048
                                                      SLC22A15; solute carrier family 22 member 15
                                                      4 of 15
                                                      608275
                                                          SLC22A25; solute carrier family 22 member 25
                                                          4 of 15
                                                          610792
                                                              SLC22A17; solute carrier family 22 member 17
                                                              3 of 15
                                                              611461
                                                                  SLC22A23; solute carrier family 22 member 23
                                                                  3 of 15
                                                                  611697
                                                                      SLC22A24; solute carrier family 22 member 24
                                                                      3 of 15
                                                                      611698
                                                                          SLC22A31; solute carrier family 22 member 31
                                                                          3 of 15
                                                                              SVOP; SV2 related protein
                                                                              3 of 15
                                                                              611699
                                                                                  Functional Complementation Data
                                                                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                                  Interactions
                                                                                  Summary of Physical Interactions
                                                                                  esyN Network Diagram
                                                                                  Interactions Browser
                                                                                  Summary of Genetic Interactions
                                                                                  esyN Network Diagram
                                                                                  Starting gene(s)
                                                                                  Interaction type
                                                                                  Interacting gene(s)
                                                                                  Reference
                                                                                  Starting gene(s)
                                                                                  Interaction type
                                                                                  Interacting gene(s)
                                                                                  Reference
                                                                                  External Data
                                                                                  Linkouts
                                                                                  BioGRID - A database of protein and genetic interactions.
                                                                                  DroID - A comprehensive database of gene and protein interactions.
                                                                                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                                                  Pathways
                                                                                  Signaling Pathways (FlyBase)
                                                                                  Metabolic Pathways
                                                                                  External Data
                                                                                  Linkouts
                                                                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                                  Genomic Location and Detailed Mapping Data
                                                                                  Chromosome (arm)
                                                                                  3R
                                                                                  Recombination map

                                                                                  3-84

                                                                                  Cytogenetic map
                                                                                  95F8-95F8
                                                                                  Sequence location
                                                                                  3R:24,276,260..24,278,792 [+]
                                                                                  FlyBase Computed Cytological Location
                                                                                  Cytogenetic map
                                                                                  Evidence for location
                                                                                  95F8-95F8
                                                                                  Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
                                                                                  Experimentally Determined Cytological Location
                                                                                  Cytogenetic map
                                                                                  Notes
                                                                                  References
                                                                                  FlyBase curator comment: the sequence contained in the Y12399 accession is chimeric, containing sequences from two separate genomic regions; part of the Y12399 sequence corresponds to CG6331 (Orct) at 95F, while the other part maps to an intron of CG17834 at 29D (see Shirras, 2005.5.31, personal communication to FlyBase).
                                                                                  (Shirras, 1997.4.7)
                                                                                  Experimentally Determined Recombination Data
                                                                                  Location

                                                                                  3-84

                                                                                  (FlyBase, 2016)

                                                                                  3-83.0

                                                                                  (Comeron et al., 2012)
                                                                                  Left of (cM)
                                                                                  Right of (cM)
                                                                                  Notes
                                                                                  Stocks and Reagents
                                                                                  Stocks (5)
                                                                                  Genomic Clones (15)
                                                                                   

                                                                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                                  cDNA Clones (35)
                                                                                   

                                                                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                                  cDNA clones, fully sequenced
                                                                                  BDGP DGC clones
                                                                                  Other clones
                                                                                  Drosophila Genomics Resource Center cDNA clones

                                                                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                                  cDNA Clones, End Sequenced (ESTs)
                                                                                  BDGP DGC clones
                                                                                  Other clones
                                                                                  RNAi and Array Information
                                                                                  Linkouts
                                                                                  DRSC - Results frm RNAi screens
                                                                                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                                                  Antibody Information
                                                                                  Laboratory Generated Antibodies
                                                                                   
                                                                                  Commercially Available Antibodies
                                                                                   
                                                                                  Other Information
                                                                                  Relationship to Other Genes
                                                                                  Source for database identify of

                                                                                  Source for identity of: Orct CG6331

                                                                                  (Kodira, 1999.11)
                                                                                  Source for database merge of
                                                                                  Additional comments
                                                                                  Other Comments

                                                                                  In FBrf0099562, the Orct locus is stated to be adjacent to the P{PZ}lmg03424 insertion, which is at 29D. However, the protein sequence of Orct (Q9VCA2) corresponds to the annotation CG6331, which maps to 95F. The confusion arose because the Y12399 sequence accession is chimeric, containing sequences from two separate genomic regions; part of the Y12399 sequence corresponds to CG6331 (i.e. Orct) at 95F, while the other part maps to an intron of CG17834 (which is adjacent to lmg) at 29D.

                                                                                  (Shirras, 2005.5.31)

                                                                                  FlyBase curator comment: in FBrf0125046, the Orct locus is stated to span Acer and lmg which are at 29D. However, this is now known to be an error, with Orct corresponding to annotation CG6331 at 95F. The confusion arose because the Orct accession Y12399 is chimeric (see Shirras, 2005.5.31, personal communication to FlyBase).

                                                                                  (Shirras, 2000.1.5)

                                                                                  FlyBase curator comment: in FBrf0099562, the Orct locus is stated to be adjacent to the P{PZ}lmg03424 insertion, which is at 29D. However, this is now known to be an error, with Orct corresponding to annotation CG6331 at 95F. The confusion arose because the Orct accession Y12399 is chimeric (see Shirras, 2005.5.31, personal communication to FlyBase).

                                                                                  (Taylor et al., 1997)
                                                                                  Origin and Etymology
                                                                                  Discoverer
                                                                                  Etymology
                                                                                  Identification
                                                                                  External Crossreferences and Linkouts ( 40 )
                                                                                  Sequence Crossreferences
                                                                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                                  Other crossreferences
                                                                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                                  Flygut - An atlas of the Drosophila adult midgut
                                                                                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                  InterPro - A database of protein families, domains and functional sites
                                                                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                  modMine - A data warehouse for the modENCODE project
                                                                                  Linkouts
                                                                                  BioGRID - A database of protein and genetic interactions.
                                                                                  DPiM - Drosophila Protein interaction map
                                                                                  DroID - A comprehensive database of gene and protein interactions.
                                                                                  DRSC - Results frm RNAi screens
                                                                                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                                                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                  FlyMine - An integrated database for Drosophila genomics
                                                                                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                                  Synonyms and Secondary IDs (6)
                                                                                  Datasets (0)
                                                                                  Study focus (0)
                                                                                  Experimental Role
                                                                                  Project
                                                                                  Project Type
                                                                                  Title
                                                                                  References (58)