FlyBase Gene Report: Maur\Prp

FB2025_05 , released December 11, 2025

FB2025_05 , released December 11, 2025

Gene: Maur\Prp

General Information

Symbol

Maur\Prp

Species

M. auratus

Name

Prion protein precursor

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0019963

Gene Model Status

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

PrP

Foreign Gene Data

Foreign sequence; species == Mesocricetus auratus; gene == 'Prp'; UniProt:P04273.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Maur\Prp

Transgenic constructs containing regulatory region of Maur\Prp

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^elav.PU

Maur\Prp^UAS.cFa

Other Phenotypes

Allele

abnormal locomotor behavior, with Scer\GAL4^BG380

Maur\Prp^UAS.cFa

abnormal locomotor behavior | adult stage, with Scer\GAL4^BG380

Maur\Prp^UAS.cFa

abnormal locomotor behavior | adult stage | progressive, with Maur\Prp^CJD.UAS, Scer\GAL4^elav-C155

Maur\Prp^WT.UAS

abnormal locomotor behavior | adult stage | progressive, with Maur\Prp^WT.UAS, Scer\GAL4^elav-C155

Maur\Prp^CJD.UAS

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Act.PU

Maur\Prp^UAS.cFa

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^BG380

Maur\Prp^UAS.cFa

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

abnormal locomotor behavior | adult stage | progressive | heat sensitive, with Scer\GAL4^BG380, Scer\GAL80^ts.αTub84B

Maur\Prp^UAS.cFa

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^ey-OK107

Maur\Prp^UAS.cFa

abnormal neuroanatomy | progressive, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

abnormal neuroanatomy | progressive, with Scer\GAL4^ey-OK107

Maur\Prp^UAS.cFa

Phenotype manifest in

Allele

adult brain, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

adult brain | progressive, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

adult brain cell body rind, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

adult brain cell body rind | progressive, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

adult mushroom body alpha-lobe, with Scer\GAL4^ey-OK107

Maur\Prp^UAS.cFa

adult mushroom body alpha-lobe | progressive, with Scer\GAL4^ey-OK107

Maur\Prp^UAS.cFa

adult optic lobe, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

adult optic lobe | adult stage | progressive, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

Kenyon cell, with Scer\GAL4^ey-OK107

Maur\Prp^UAS.cFa

neuropil, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

neuropil | adult stage | progressive, with Scer\GAL4^da.G32

Maur\Prp^UAS.cFa

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

Maur\Prp^UAS.cFa

model of prion disease

CEA

(Myers et al., 2022, Zhang et al., 2014, Fernandez-Funez et al., 2010, Fernandez-Funez et al., 2009)

Maur\Prp^WT.UAS

model of prion disease

CEA with Maur\Prp^FFI.UAS

(Thackray et al., 2017)

CEA with Maur\Prp^CJD.UAS

(Thackray et al., 2017)

Maur\Prp^FFI.UAS

model of prion disease

CEA with Maur\Prp^WT.UAS

(Thackray et al., 2017)

Maur\Prp^CJD.UAS

model of prion disease

CEA with Maur\Prp^WT.UAS

(Thackray et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Maur\Prp^UAS.cFa

model of prion disease

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Fernandez-Funez et al., 2009)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (0)

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

HaPrP

(Fernandez-Funez et al., 2010)

Hamster PrP

(Fernandez-Funez et al., 2017)

Maur\Prp

PrP

(Thackray et al., 2017, Fernandez-Funez et al., 2010, Raeber et al., 1993)

Prnp

(Fernandez-Funez et al., 2009)

Prp

(Zhang et al., 2014)

Name Synonyms

Prion protein precursor

hamster PrP

(Zhang et al., 2014)

prion protein

(Fernandez-Funez et al., 2010)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (11)