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Gene Dmel\Ice

General Information
Symbol	Dmel\Ice	Species	D. melanogaster
Name	Ice	Annotation symbol	CG7788
Feature type	protein_coding_gene	FlyBase ID	FBgn0019972
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	drICE, crice
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99C1-99C1	Sequence location	3R:25,625,380..25,627,306 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ice is referred to in FlyBase by the symbol Dmel\Ice (CG7788, FBgn0019972). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: salivary gland histolysis; spermatid differentiation; programmed cell death; nurse cell apoptotic process; sterol regulatory element binding protein cleavage; neuron remodeling; positive regulation of compound eye retinal cell programmed cell death; response to X-ray; developmental programmed cell death. 33 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult; external compound sense organ; adult segment; multicellular structure; imaginal precursor; thoracic segment; cell part; embryonic/larval imaginal precursor. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, ICE, catalytic subunit p20, active site; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634668_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ice. Gene sequence location is 3R:25625380..25627306.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99C1-99C1   Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ice for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ice-RA FBtr0085482  NM_079827   1927   339
Additional Transcript Data & Comments
Reported size (kB)	1.02 (longest cDNA) (Fraser and Evan, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ice-PA   FBpp0084848   37.4   339   7.07     NP_524551   AAF56939
Additional Polypeptide Data & Comments
Reported size (kDa)	339 (aa) (Fraser and Evan, 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) Peptidase C14, ICE, catalytic subunit p20, active site (IPR016129) MEROPS - An information resource for peptidases and the proteins that inhibit them • C14.015
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392006   AA439676   AA695198   AA698434   AA950438   AA950801   AE014297 AAF56939   AI260677   AI294203   AI403610   AI404544   AI455184   AI455574   AI456807   AI456990   AI511850   AI512195   AI512501   AI514905   AI519418   AI542262   AI544116   AI544228   AI546388   AW941865   AY058451 AAL13680   BG641044   BI164684   BI172124   BI172546   BI172586   BI172619   BI173690   BI214945   BI232405   BI234518   BI240573   BI240600   BI357770   BI362090   BI365638   BI373129   BI374068   BI483722   BI483818   BI484207   BI579890   BI632574   BI640006   CA804517   CA806273   CA806745   CK660560   CO152789   CO178078   CO267551   CO269456   CO337088   CO344751   EC051640   EC053143   EC053624   EC054633   EC055694   EC056145   EC207187   EC210549   EC222815   EC249781   EC255141   EC266069   EC266275   GO254594   Y12261 CAA72937
UniProtKB/Swiss-Prot	O01382
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Fraser and Evan, 1997) pupal stage   salivary gland   (Lee et al., 2003)
Additional Descriptive Data
	The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue. (Lee et al., 2003) Ice transcript is expressed in all developmental stages, with highest levels detected in 2-6 hr embryos. (Fraser and Evan, 1997)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference prepupal stage P4 -- pupal stage P5   salivary gland   • cytoplasm (Martin and Baehrecke, 2004) Comment:10-14 hr APF; activated form spermatogenesis & adult stage | male   spermatid cyst   • cytoplasm (Arama et al., 2003) Comment:preindividualized part of cyst cystic bulge   (Arama et al., 2003) waste bag   (Arama et al., 2003) oogenesis stage S10 -- S12   nurse cell   • cytoplasm | punctate (Peterson et al., 2003)
Additional Descriptive Data
	Ice protein detected by an antibody specific to the activated form is observed in the cytoplasm of salivary glands beginning at 10 hours APF. Levels increase with time, and activated Ice protein is abundant at 14 hours APF. (Martin and Baehrecke, 2004) An antibody thatspecifically recognizes the activated form of Ice was used to examine expression of this protein during apoptosis that occurs in nurse cells during oogenesis. Foci of activated Ice staining was first observed near nuclei of the nurse cells closest to the oocyte. Later, at stage 12, increased expression of Ice was observed in all nurse cells. (Peterson et al., 2003) Active Ice protein is observed to accumulate in the cytoplasm of preindividualized part of the spermatid cyst, and in the cystic bulge, but is not detectable in the postindividualized part of the spermatid cyst. Inactive Ice protein is observed uniformly in preindividualizing spermatid cysts. (Arama et al., 2003)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    681.75 Larval Midgut    938.2 Larval Hindgut    566.7 Larval Malpighian Tubules    952.5 Larval Fat Body    529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass    981.225 Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary    552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (681.75) Larval Midgut  (938.2) Larval Hindgut  (566.7) Larval Malpighian Tubules  (952.5) Larval Fat Body  529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass  (981.225) Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary  (552.2) Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    681.75 Larval Midgut    938.2 Larval Hindgut    566.7 Larval Malpighian Tubules    952.5 Larval Fat Body    529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass    981.225 Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary    552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    681.75 Larval Midgut    938.2 Larval Hindgut    566.7 Larval Malpighian Tubules    952.5 Larval Fat Body    529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass    981.225 Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary    552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    681.75 Larval Midgut    938.2 Larval Hindgut    566.7 Larval Malpighian Tubules    952.5 Larval Fat Body    529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass    981.225 Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary    552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  681.75 Larval Midgut  (938.2) Larval Hindgut  566.7 Larval Malpighian Tubules  (952.5) Larval Fat Body  529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass  (981.225) Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary  552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    681.75 Larval Midgut    938.2 Larval Hindgut    566.7 Larval Malpighian Tubules    952.5 Larval Fat Body    529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass    981.225 Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary    552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    681.75 Larval Midgut    938.2 Larval Hindgut    566.7 Larval Malpighian Tubules    952.5 Larval Fat Body    529 Larval Salivary Gland    222.3 Larval Trachea    462.55 Larval Carcass    981.225 Adult Head    165.7 Adult Eye    106.6 Adult Brain    120.3 Adult Thoracic-Abdominal Ganglion    92.9 Adult Crop    303.6 Adult Midgut    417.5 Adult Hindgut    239.6 Adult Malpighian Tubules    332 Adult Fat Body    480.7 Adult Salivary Gland    116 Adult Heart    242.95 Adult VirginFemale Spermatheca    347.4 Adult InseminatedFemale Spermatheca    278.5 Adult Ovary    552.2 Adult Testis    48.2 Adult Male Accessory Gland    77.6 Adult Carcass    237.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    165.7   NA  Eye    106.6   NA  Brain    120.3   681.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    92.9   NA  Crop    303.6   938.2  Midgut    417.5   566.7  Hindgut    239.6   952.5  Malpighian Tubules    332   529  Fat Body    480.7   222.3  Salivary Gland    116   NA  Heart    242.95   462.55  Trachea    NA   NA  VirginFemale Spermatheca    347.4   NA  InseminatedFemale Spermatheca    278.5   NA  Ovary    552.2   NA  Testis    48.2   NA  Male Accessory Gland    77.6   981.225  Carcass    237.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    108 digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering    42 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female    57 ovary, mated 4-day female    39 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  (32) central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  (108) digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering  (42) carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (39) testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    35 digestive system, larvae L3 wandering  (108) digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering    42 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female    57 ovary, mated 4-day female    39 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    108 digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering    42 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female    57 ovary, mated 4-day female    39 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    108 digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering    42 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female    57 ovary, mated 4-day female    39 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  (108) digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering  (42) carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (39) testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    35 digestive system, larvae L3 wandering  108 digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering    42 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female    57 ovary, mated 4-day female    39 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    32 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    9 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    108 digestive system, 1-day adult    14 digestive system, 4-day adult    10 digestive system, 20-day adult    17 fat body, larvae L3 wandering    12 fat body, white prepupae    19 fat body, pupae P8    22 carcass, larvae L3 wandering    42 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    10 ovary, virgin 4-day female    57 ovary, mated 4-day female    39 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    110 embryo 04-06hr    120 embryo 06-08hr    78 embryo 08-10hr    68 embryo 10-12hr    69 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    21 embryo 20-22hr    35 embryo 22-24hr    30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    57 white prepupae new    67 white prepupae 12hr    55 white prepupae 24hr    38 pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP    44 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day    31 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (110) embryo 04-06hr  (120) embryo 06-08hr  (78) embryo 08-10hr  (68) embryo 10-12hr  (69) embryo 12-14hr  (36) embryo 14-16hr  (31) embryo 16-18hr  26 embryo 18-20hr    21 embryo 20-22hr  (35) embryo 22-24hr  (30) larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2  (28) larva L3 puffstage 3-6  (47) larva L3 puffstage 7-9  (57) white prepupae new  (67) white prepupae 12hr  (55) white prepupae 24hr  (38) pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP  (44) adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day  (31) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr  (110) embryo 04-06hr  (120) embryo 06-08hr    78 embryo 08-10hr    68 embryo 10-12hr    69 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    21 embryo 20-22hr    35 embryo 22-24hr    30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    57 white prepupae new    67 white prepupae 12hr    55 white prepupae 24hr    38 pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP    44 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day    31 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    110 embryo 04-06hr    120 embryo 06-08hr    78 embryo 08-10hr    68 embryo 10-12hr    69 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    21 embryo 20-22hr    35 embryo 22-24hr    30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    57 white prepupae new    67 white prepupae 12hr    55 white prepupae 24hr    38 pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP    44 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day    31 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    110 embryo 04-06hr    120 embryo 06-08hr    78 embryo 08-10hr    68 embryo 10-12hr    69 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    21 embryo 20-22hr    35 embryo 22-24hr    30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    57 white prepupae new    67 white prepupae 12hr    55 white prepupae 24hr    38 pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP    44 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day    31 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (110) embryo 04-06hr  (120) embryo 06-08hr  (78) embryo 08-10hr  (68) embryo 10-12hr  (69) embryo 12-14hr  (36) embryo 14-16hr  31 embryo 16-18hr  26 embryo 18-20hr    21 embryo 20-22hr  (35) embryo 22-24hr  30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2  28 larva L3 puffstage 3-6  (47) larva L3 puffstage 7-9  (57) white prepupae new  (67) white prepupae 12hr  (55) white prepupae 24hr  (38) pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP  (44) adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day  31 adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr  110 embryo 04-06hr  120 embryo 06-08hr    78 embryo 08-10hr    68 embryo 10-12hr    69 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    21 embryo 20-22hr    35 embryo 22-24hr    30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    57 white prepupae new    67 white prepupae 12hr    55 white prepupae 24hr    38 pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP    44 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day    31 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    110 embryo 04-06hr    120 embryo 06-08hr    78 embryo 08-10hr    68 embryo 10-12hr    69 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    21 embryo 20-22hr    35 embryo 22-24hr    30 larva L1    6 larva L2    6 larva L3 12hr old    10 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    57 white prepupae new    67 white prepupae 12hr    55 white prepupae 24hr    38 pupae 2d postWPP    20 pupae 3d postWPP    11 pupae 4d postWPP    44 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    23 adult female 05day    31 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    72 Schneider line 2 Sg4    49 embryonic 1182-4H    31 embryonic GM2    14 embryonic Kc167    19 embryonic S1    97 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    45 wing disc ML-DmD8    70 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    81 mixed discs ML-DmD4-c1    65 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    85 ovary fGS/OSS    55 ovary OSC    47 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (72) Schneider line 2 Sg4  (49) embryonic 1182-4H  (31) embryonic GM2    14 embryonic Kc167    19 embryonic S1  (97) embryonic S3  (28) leg disc CME L1  (33) wing disc CME-W2  (45) wing disc ML-DmD8  (70) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (78) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (55) antennal disc ML-DmD20-c5  (81) mixed discs ML-DmD4-c1  (65) CNS ML-DmBG1-c1  (28) CNS ML-DmBG2-c2  (76) tumorous blood cells mbn2  (85) ovary fGS/OSS  (55) ovary OSC  (47) ovary OSS  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    72 Schneider line 2 Sg4    49 embryonic 1182-4H    31 embryonic GM2    14 embryonic Kc167    19 embryonic S1    97 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    45 wing disc ML-DmD8    70 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    81 mixed discs ML-DmD4-c1    65 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    85 ovary fGS/OSS    55 ovary OSC    47 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    72 Schneider line 2 Sg4    49 embryonic 1182-4H    31 embryonic GM2    14 embryonic Kc167    19 embryonic S1    97 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    45 wing disc ML-DmD8    70 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    81 mixed discs ML-DmD4-c1    65 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    85 ovary fGS/OSS    55 ovary OSC    47 ovary OSS    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    72 Schneider line 2 Sg4    49 embryonic 1182-4H    31 embryonic GM2    14 embryonic Kc167    19 embryonic S1    97 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    45 wing disc ML-DmD8    70 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    81 mixed discs ML-DmD4-c1    65 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    85 ovary fGS/OSS    55 ovary OSC    47 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (72) Schneider line 2 Sg4  (49) embryonic 1182-4H  31 embryonic GM2    14 embryonic Kc167    19 embryonic S1  (97) embryonic S3  28 leg disc CME L1  (33) wing disc CME-W2  (45) wing disc ML-DmD8  (70) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (78) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (55) antennal disc ML-DmD20-c5  (81) mixed discs ML-DmD4-c1  (65) CNS ML-DmBG1-c1  28 CNS ML-DmBG2-c2  (76) tumorous blood cells mbn2  (85) ovary fGS/OSS  (55) ovary OSC  (47) ovary OSS  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    72 Schneider line 2 Sg4    49 embryonic 1182-4H    31 embryonic GM2    14 embryonic Kc167    19 embryonic S1    97 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    45 wing disc ML-DmD8    70 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    81 mixed discs ML-DmD4-c1    65 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    85 ovary fGS/OSS    55 ovary OSC    47 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    72 Schneider line 2 Sg4    49 embryonic 1182-4H    31 embryonic GM2    14 embryonic Kc167    19 embryonic S1    97 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    45 wing disc ML-DmD8    70 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    81 mixed discs ML-DmD4-c1    65 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    85 ovary fGS/OSS    55 ovary OSC    47 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    34 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    35 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3  (34) Cadmium 50 mM 12 hrs, larvae L3  (46) Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3  (32) Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (33) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (31) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3  (35) Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    34 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    35 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    34 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    35 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    34 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    35 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3  (34) Cadmium 50 mM 12 hrs, larvae L3  (46) Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3  32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (33) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3  (35) Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    34 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    35 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    34 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    35 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH24292 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019972 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7788-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ice Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage IceΔ1 partially lethal - majority die (with Df(3R)Ice) Ice17 partially lethal - majority die | embryonic stage Ice17 partially lethal - majority die | larval stage IceΔ1 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 IceGD12284 viable IceΔ1A1 Sterility Allele fertile IceΔ1A1 male fertile IceΔ1 semi-sterile Ice17 Other Phenotypes Allele cell death defective IceΔ1 cell death defective, with Scer\GAL4Crz.504 IcemiRNA.L.Scer\UAS cell death defective | drug conditional IceΔ1 cell death defective | somatic clone IceΔ1 decreased cell death IcedsRNA.cKa IceΔ1 IceΔ2C8 decreased cell death | embryonic stage Ice17 developmental rate defective | partially | pupal stage IceΔ1 increased cell death Icehs.PK radiation resistant IceΔ1 radiation resistant, with Scer\GAL4en-e16E IcemiRNA.Scer\UAS tumorigenic | pupal stage IceΔ1 visible Ice17 IceGMR.PU visible, with IceP10.GMR IceP20.GMR visible, with IceP20.GMR IceP10.GMR wild-type Icefl.GMR IceΔN.GMR Phenotype manifest in Allele adult abdomen IceΔ1 arista IceΔ1 dendrite, with Scer\GAL4ppk.PG IcedsRNA.Scer\UAS dendrite (with Ice17), with Scer\GAL4ppk.PG IceΔ1 dendrite (with IceΔ1), with Scer\GAL4ppk.PG Ice17 eye IceGMR.PU eye, with IceP10.GMR IceP20.GMR eye, with IceP20.GMR IceP10.GMR eye disc Ice17 IceΔ2C8 eye disc | somatic clone Ice17 inter-ommatidial precursor cell | pharate adult stage P9 | supernumerary, with Scer\GAL4GMR.PF IcedsRNA.Scer\UAS.cLa inter-ommatidial precursor cell | pupal stage | supernumerary Ice17 male genitalia IceΔ1 midline glial cell IceΔ1 Ice17 neuron IceΔ1 neuron, with Scer\GAL4Crz.504 IcemiRNA.L.Scer\UAS neuron, with Scer\GAL4ppk.PG IcedsRNA.Scer\UAS neuron (with Ice17), with Scer\GAL4ppk.PG IceΔ1 neuron (with IceΔ1), with Scer\GAL4ppk.PG Ice17 retina IceΔ1 salivary gland | pupal stage, with Scer\GAL434B IcedsRNA.Scer\UAS.cLa spermatid cyst IceΔ1 wing IceΔ1 Ice17 wing | somatic clone IceΔ1 wing disc IceΔ1
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Ice Class Mutagen Stocks Known lesion Ice17 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes IceGE28489 P-element activity 0 Yes Iceunspecified 0 -- IceΔ1 P-element activity 0 Yes IceΔ1A1 P-element activity 0 Yes IceΔ1E4 P-element activity 0 Yes IceΔ2C8 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ice Class Mutagen Stocks Known lesion IceGD12284 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes IceHMS00398 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ice+t2.4 in vitro construct - genomic fragment 0 Yes Ice81-339.MtnA in vitro construct - regulatory fusion 0 Yes Icea.cIa in vitro construct - RNAi in vitro construct 0 Yes IcecIa in vitro construct - RNAi in vitro construct 0 Yes IceDcp-1.5'3'UTR in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes IcedsRNA.84-763 in vitro construct - RNAi 0 Yes IcedsRNA.cKa in vitro construct - RNAi 0 Yes IcedsRNA.Scer\UAS.cLa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes IcedsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 -- Icefl.5'3'UTR in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes Icefl.GMR in vitro construct - regulatory fusion 0 Yes IceGMR.PU in vitro construct - regulatory fusion 0 Yes Icehs.PK in vitro construct - regulatory fusion 0 Yes IcemiRNA.L.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes IcemiRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes IceMtnA.C:A.T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes IceMtnA.PF in vitro construct - regulatory fusion 0 Yes IceNIG.7788R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes IceP10.GMR 0 Yes IceP20.GMR 0 Yes IceScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes IceScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes IceT:Zzzz\His6 in vitro construct - coding region fusion 0 Yes IceΔN.GMR in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Ice (Xu et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12284} NA P{NIG.7788R} NA P{TRiP.HMS00398} NA P{UAS-Ice.dsRNA} NA P{UAS-Ice.miRNA} NA P{UAS-Ice.Y} NA characterization construct P{GMR-fl-Ice} NA P{GMR-Ice.P10} NA P{GMR-Ice.P20} NA P{GMR-Ice.U} NA P{GMR-ΔN-Ice} NA P{Ice+t2.4} NA PBac{Dcp-1.5':Ice:Dcp-1.3'} NA PBac{Ice.5'3'UTR} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}IceGE28489 NA miscellaneous insertions P{?EP}IceΔ1 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from direct assay (Kanuka et al., 2005)
Biological Process
CV term Evidence References
developmental programmed cell death inferred from mutant phenotype (Kondo et al., 2006) neuron remodeling inferred from mutant phenotype (Schoenmann et al., 2010) nurse cell apoptotic process inferred from genetic interaction with Dcp-1 (Baum et al., 2007) positive regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Leulier et al., 2006) programmed cell death inferred from direct assay (Lee et al., 2011) inferred from mutant phenotype (Muro et al., 2006) response to X-ray inferred from mutant phenotype (Muro et al., 2006) salivary gland histolysis inferred from mutant phenotype (Leulier et al., 2006) spermatid differentiation inferred from mutant phenotype (Muro et al., 2006) sterol regulatory element binding protein cleavage inferred from direct assay (Amarneh et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with human CASP3 AND inferred from sequence or structural similarity with human CASP6 (Fraser and Evan, 1997) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Brachmann and Cagan, 2003, Tittel and Steller, 2000, Bergmann et al., 2003, Abrams, 1999)
Biological Process
CV term Evidence References
apoptotic process traceable author statement (Richardson and Kumar, 2002, Bergmann et al., 2003) proteolysis inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR002398, InterPro:IPR011600, InterPro:IPR016129 (FlyBase Curators et al., 2004-) traceable author statement (Bergmann et al., 2003) regulation of retinal cell programmed cell death non-traceable author statement (Brachmann and Cagan, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ice - CG10209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ice - CG10566 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ice - CG30344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ice - CG3793 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ice - CG6439 experimental knowledge based (Guruharsha et al., 2011) Ice - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ice - CG7277 experimental knowledge based (Guruharsha et al., 2011) Ice - CG8026 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ice - Lapsyn experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ice - MtnA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ice - Nedd8 anti bait coimmunoprecipitation, western blot (Broemer et al., 2010) Ice - Teh1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ice - Timp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ice - tmod anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ice allele Gene References Icea.cIa rpr (Igaki et al., 2002) IcecIa rpr (Igaki et al., 2002) Icefl.GMR rpr (Song et al., 2000) Icehs.PK Ark (Kanuka et al., 1999) unspecified Dcp-1 (Muro et al., 2006) grim (Muro et al., 2006) rpr (Muro et al., 2006) th (Muro et al., 2006) W (Muro et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68378 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0019972 DroID - A comprehensive database of gene and protein interactions. • FBgn0019972 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43514
Orthologs
OrthoDB Orthologs (82) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NZVDC Dipteran inclusive ortholog search EOG6TF0V1 Insect inclusive ortholog search EOG6NP60S Arthropod inclusive ortholog search EOG6F1VKC Metazoa inclusive ortholog search EOG654NTB
Orthologs in Drosophila Species (EOG6NZVDC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ice     Drosophila simulans   Dsim\GD21467 Y   Drosophila sechellia   Dsec\GM12823 Y   Drosophila yakuba   Dyak\GE23886 Y   Drosophila ananassae   Dana\GF18666 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20588 Y   Drosophila persimilis   Dper\GL23515 Y   Drosophila willistoni   Dwil\GK11928 Y   Drosophila virilis   Dvir\GJ24096 Y   Drosophila mojavensis   Dmoj\GI22043 Y   Drosophila grimshawi   Dgri\GH19956 Y
Orthologs in non-Drosophila Dipterans (EOG6TF0V1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012143 Y Anopheles gambiae Malaria mosquito  Agam\CASPS7 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802232 Y
Orthologs in non-Dipteran Insects (EOG6NP60S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC412235 Y Apis mellifera Western honey bee  Amel\GB41369 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003516 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010240 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010089 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010095 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19630 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10628 Y Atta cephalotes Leafcutter ant  Acep\ACEP10275 Y Atta cephalotes Leafcutter ant  Acep\ACEP16299 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21999 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO11803 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21486 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23623 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22042 Y Linepithema humile Argentine ant  Lhum\LH17480 Y Linepithema humile Argentine ant  Lhum\LH11050 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27284 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27285 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24677 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27282 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27283 Y Solenopsis invicta Red fire ant  Sinv\SINV16269 Y Solenopsis invicta Red fire ant  Sinv\SINV13920 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003462 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001931 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004566 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003094 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006946 Y Pediculus humanus Human body louse  Phum\PHUM536790 Y Pediculus humanus Human body louse  Phum\PHUM221390 Y Tribolium castaneum Red flour beetle  Tcas\TC003841 Y
Orthologs in non-Insect Arthropods (EOG6F1VKC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rbcL Y Daphnia pulex Water flea  Dpux\JGI_V11_7107 Y Daphnia pulex Water flea  Dpux\JGI_V11_314077 Y Daphnia pulex Water flea  Dpux\JGI_V11_56759 Y Daphnia pulex Water flea  Dpux\JGI_V11_307426 Y Daphnia pulex Water flea  Dpux\JGI_V11_314078 Y Daphnia pulex Water flea  Dpux\JGI_V11_15026 Y Daphnia pulex Water flea  Dpux\EF2 Y Daphnia pulex Water flea  Dpux\JGI_V11_309162 Y Ixodes scapularis Deer tick  Isca\ISCW003039 Y Ixodes scapularis Deer tick  Isca\ISCW013172 Y
Orthologs in non-Arthropod Metazoa (EOG654NTB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008746gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002280gn Y Danio rerio Zebrafish  Drer\casp6 Y Danio rerio Zebrafish  Drer\casp6l2 Y Danio rerio Zebrafish  Drer\CABZ01041682.1 Y Danio rerio Zebrafish  Drer\casp6l1 Y Danio rerio Zebrafish  Drer\casp7 Y Danio rerio Zebrafish  Drer\casp3b Y Xenopus tropicalis Western clawed frog  Xtro\casp6 Y Xenopus tropicalis Western clawed frog  Xtro\casp3 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030678 Y Xenopus tropicalis Western clawed frog  Xtro\casp7 Y Gallus gallus Domestic chicken  Ggal\CASP3 Y Gallus gallus Domestic chicken  Ggal\CASP6 Y Gallus gallus Domestic chicken  Ggal\CASP7 Y Mus musculus House mouse  Mmus\Casp7 Y Mus musculus House mouse  Mmus\Casp3 Y Mus musculus House mouse  Mmus\Casp6 Y Rattus norvegicus Norway rat  Rnor\Casp3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032779 Y Rattus norvegicus Norway rat  Rnor\Casp7 Y Rattus norvegicus Norway rat  Rnor\Casp6 Y Homo sapiens Human  Hsap\CASP3 Y Homo sapiens Human  Hsap\CASP7 Y Homo sapiens Human  Hsap\ENSG00000138794 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\CASP3     Hsap\CASP7     Hsap\ENSG00000138794
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21467 Drosophila sechellia Dsec\GM12823 Drosophila yakuba Dyak\GE23886 Drosophila ananassae Dana\GF18666 Drosophila pseudoobscura pseudoobscura Dpse\GA20588 Drosophila persimilis Dper\GL23515 Drosophila willistoni Dwil\GK11928 Drosophila virilis Dvir\GJ24096 Drosophila mojavensis Dmoj\GI22043 Drosophila grimshawi Dgri\GH19956
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	32403 y1 sc* v1; P{TRiP.HMS00398}attP2
VDRC	v28065 w1118; P{GD12284}v28065 v28064 w1118; P{GD12284}v28064/TM3
Genomic Clones ( 2 )
	BACR02E15 BACR02O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH24292
Other clones	DPiM_GH24292
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH23084 GM02390 HL04502 LD10939 LD14307 LD21661 LD29701 LD30220 LD30933 LD36940 LD37184 LD39017 LD43389 LD43955 LD44391 LD46350 LD46535 LD47689 LD47950 LP04630 LP07524 LP19218 RE04407 RE14089 RE15069 RE15118 RE15153 RE16770 RE21109 RE28467 RE30228 RE37445 RE37479 RE44332 RE46561 RE51009 RE60347 RE61581 RE66646 RE66767 RE73987 SD08483 SD12271 SD22756 SD26388
Other clones	38013 53190 160393 214381.25 473653 562144 CK01.69A.H3 EC051640 EC053143 EC053624 EC054633 EC055694 EC056145 EK055230 EK094604 EK150810 EN00441 EN13814 EP19832 ESG012c.E21_D12 ESG014d.E21_D08 ESG0114a.B21_B01 RE67269 RP01844
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0019972 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43514
Antibody Information
	polyclonal (Lannan et al., 2007) polyclonal antibody CM1 (Arama et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Ice is activated in wing discs after irradiation. (Florentin and Arama, 2012) th blocks effector caspases by targeting them for polyubiquitylation and nonproteasomal inactivation. (Ditzel et al., 2008) Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) A CED-4-like P-loop-containing ATPase is involved in the activation of Ice to promote the cell death program in Drosophila. (Kanuka et al., 1999) Overexpression of Ice sensitizes cells to apoptotic stimuli and expression of an N-terminally truncated form rapidly induces apoptosis. Ice is a Cys protease that cleaves baculovirus p35 and Lam in vitro and Ice is expressed at all stages of development at which programmed cell death can be induced. These results strongly suggest that Ice is an apoptotic caspase that acts downstream of rpr. (Fraser and Evan, 1997) Ice encodes an essential caspase required for apoptotic activity in Drosophila cells. (Fraser et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079827 RefSeq (Proteins) • NP_524551 DDBJ / EMBL / GenBank • AAF56939 AAL13680 AI404544 AW941865 AY058451 CAA72937 Y12261 Entrez Gene - A searchable database of RefSeq genes. • 43514 UniProtKB/Swiss-Prot • O01382
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) Peptidase C14, ICE, catalytic subunit p20, active site (IPR016129) MEROPS - An information resource for peptidases and the proteins that inhibit them • C14.015 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH24292
Linkouts
	BioGRID - A database of protein and genetic interactions • 68378 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0019972 DroID - A comprehensive database of gene and protein interactions. • FBgn0019972 DRSC - Results from RNAi screens. • FBgn0019972 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019972 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7788-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0019972 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43514 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/drice1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43514 modMine - Data generated by the modENCODE project. • FBgn0019972
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	caspase 3 (Wichmann et al., 2006) CG7788 (Lee et al., 2003, Irving et al., 2001, Pal et al., 2007, Sun et al., 2010, Wagner et al., 2009, Ni et al., 2010.12.1) crice (Zeitouni et al., 2007, Amarneh et al., 2009) drICE (Arama et al., 2006, Tenev et al., 2005, Arama and Steller, 2005, Manaka et al., 2004, Igaki and Miura, 2004, Zachariou et al., 2003, Kessler and Muller, 2003, Olson et al., 2003, Bergmann et al., 2003, Jabbour et al., 2002, Kessler and Mueller, 2004, Arama and Steller, 2004, Bergmann and Lane, 2003, Ditzel et al., 2003, Tittel and Steller, 2000, Igaki et al., 2002, Bialik and Gottlieb, 2000, Meier et al., 2000, Huh et al., 2001, Bangs et al., 2000, Vernooy et al., 2000, Hawkins et al., 2000, Yokoyama et al., 2000, Song et al., 2000, White, 2000, Meier et al., 2000, White, 1999, Zhou et al., 1999, Kanuka et al., 1999, Rodriguez et al., 1999, Dorstyn et al., 1999, Wang et al., 1999, Miller, 1999, McNeill and Downward, 1999, Deveraux and Reed, 1999, Kanuka et al., 1999, Bergmann et al., 1999, Bergmann et al., 1998, Kaiser et al., 1998, Fraser et al., 1997, McCall and Steller, 1997, Fraser and Evan, 1997, Xu et al., 2006, Shin and Yoo, 2007, Kim and Yoo, 2007, Xu and Bergmann, 2007, Ribeiro et al., 2007, Wichmann et al., 2006, Xu and Bergmann, 2008, Li et al., 2011, Luque and Milan, 2007, Mendes et al., 2006, Fan and Bergmann, 2008, Ribeiro et al., 2007, Xu et al., 2006, Lee et al., 2009, Kessler and Müller, 2009, Creagh et al., 2009, Tenev et al., 2007, Ditzel et al., 2008, Arama et al., 2007, Ertürk-Hasdemir et al., 2009, Fan and Bergmann, 2010, Bardet et al., 2008, Broemer et al., 2010, Yang et al., 2010) Drice (Perez-Garijo et al., 2005, Vidal and Cagan, 2006, Wienholds, 2005, Udan et al., 2003, Hanyu-Nakamura et al., 2004, Adams and Cory, 2001, Abrams, 1999, Singh and Choi, 2005, Baum et al., 2005, Xu et al., 2004, Hay et al., 2004, Martin and Baehrecke, 2004, He and Hannon, 2004, Huh et al., 2004, Moreno and Basler, 2004, Sen et al., 2004, Gendre et al., 2004, Lawen, 2003, Jia et al., 2003, Lee et al., 2003, Baehrecke, 2003, Adams and Cory, 2002, Kumar, 2000, Cagan, 2003, Peterson et al., 2003, Xu et al., 2003, Yoo et al., 2002, Anonymous, 2003, Ambros, 2003, Van Hoof and Goris, 2003, Claveria and Torres, 2003, Brachmann and Cagan, 2003, Kango-Singh et al., 2002, Tapon et al., 2002, Richardson and Kumar, 2002, Yu et al., 2002, Gorski and Marra, 2002, Yu et al., 2001, Vernooy et al., 2000, Singh et al., 2006, Chew et al., 2007, Agnès et al., 2007, Huh et al., 2007, Baehrecke, 2006, Montell, 2006, Li et al., 2002, Li and Cadigan, 2008, Pret et al., 2008, Baehrecke, 2003, Guan et al., 2007, Sato et al., 2007, Umemori et al., 2009, Muro et al., 2004, Lee et al., 2005, Primrose et al., 2007, Cabernard and Affolter, 2005, Copeland et al., 2007, Ribaya et al., 2009, Liu et al., 2009, Lee et al., 2006, Chew et al., 2009, Guha et al., 2008, Bardet et al., 2008, Biteau et al., 2008, Keller et al., 2011, Florentin and Arama, 2012, Marchal et al., 2012, Verghese et al., 2012) drice (Zheng et al., 2005, Kilpatrick et al., 2005, Kondo et al., 2005, McCall, 2004, Kumar and Cakouros, 2004, Lai, 2003, Cakouros et al., 2004, Kumar et al., 2003, Kumar and Doumanis, 2000, McCall et al., 2007, Herranz et al., 2006, Baum et al., 2007, Denton et al., 2008, Kondo et al., 2006, Khammari et al., 2011, Ozdemir and Rawson, 2011, Sharma and Fitzgerald, 2010, Link et al., 2007, Denton et al., 2009, Matthews et al., 2010, Schoenmann et al., 2010, Chandrasekhar et al., 2012) DrICE (Xu et al., 2005, Yin and Thummel, 2004, Shiozaki and Shi, 2004, Hawkins et al., 1999, Fan and Bergmann, 2007, Herman-Bachinsky et al., 2007, Kuranaga and Miura, 2007, Fan and Bergmann, 2008, Kornbluth and White, 2005, Challa et al., 2007, Means et al., 2006, Mallik and Lakhotia, 2009, Yuan et al., 2011, Vandergaast et al., 2011, Yan et al., 2004, Lannan et al., 2007, Settles and Friesen, 2008, Filipiak et al., 2012) DRICE (Arama et al., 2003, Morey et al., 2003, Huh et al., 2004, Ilangovan et al., 2003, Dorstyn et al., 2002, Muro et al., 2002, Harvey et al., 2001, Dorstyn et al., 2004, Gupta et al., 2010, Daish et al., 2004, Morey et al., 2003, Dorstyn and Kumar, 2008, Khan et al., 2008, Snipas et al., 2008, Shukla and Tapadia, 2011) DrIce (Baehrecke, 2000, Singh and Choi, 2006, Rives et al., 2006) drIce (Leulier et al., 2006) Drive (Chen et al., 2012) ICE (Hoffmann, 2003, Ertürk-Hasdemir et al., 2009) ice (Fraser, 1997.4.3, Pal et al., 2007, Lee et al., 2011) Ice (Muro et al., 2006, Sun et al., 2010, Liu and Lehmann, 2008, Zeitouni et al., 2007, Wagner et al., 2009, Nusinow et al., 2008, Zhong and Belote, 2007, Liu et al., 2009, Kim et al., 2005, Seong et al., 2011, McGurk and Bonini, 2012, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	caspase-3 (Gupta et al., 2010, Primrose et al., 2007, Mallik and Lakhotia, 2009) Drice (Umemori et al., 2007, Chandraratna et al., 2007, Koch et al., 2009, Sprecher and Hirth, 2006) Ice (Zeitouni et al., 2007) interleukin-1β-converting enzyme (Khan et al., 2008)
Secondary FlyBase IDs
References ( 244 )
Generate a list of	All references relating to this gene ( 244 )
List References by type	Research paper  ( 148 ) Supplementary material  ( 8 ) Review  ( 47 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 28 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 20 )
	Borensztejn et al., 2013, Development 140(1): 195--204 JAK/STAT autocontrol of ligand-producing cell number through apoptosis. [FBrf0220206] Rudrapatna et al., 2013, EMBO Rep. 14(2): 172--177 Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion. [FBrf0220676] Velentzas et al., 2013, Cell Biol. Toxicol. 29(1): 13--37 Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis. [FBrf0220377] Chandrasekhar et al., 2012, Bioorg. Med. Chem. Lett. 22(1): 645--648 aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle. [FBrf0219092] Chen et al., 2012, Cell Death Differ. 19(10): 1655--1663 Effectors of alcohol-induced cell killing in Drosophila. [FBrf0219410] Filipiak et al., 2012, Biometals 25(3): 507--516 Zinc induces caspase-dependent mitochondrial pathway of the programmed cell death in haemocytes of Drosophila melanogaster. [FBrf0218311] Florentin and Arama, 2012, J. Cell Biol. 196(4): 513--527 Caspase levels and execution efficiencies determine the apoptotic potential of the cell. [FBrf0217486] Marchal et al., 2012, PLoS ONE 7(3): e34310 The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling. [FBrf0218002] McGurk and Bonini, 2012, Hum. Mol. Genet. 21(1): 76--84 Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila. [FBrf0216939] Verghese et al., 2012, Cell Death Differ. 19(10): 1664--1676 Hippo signalling controls Dronc activity to regulate organ size in Drosophila. [FBrf0219371] Keller et al., 2011, Neuron 72(5): 760--775 Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. [FBrf0216904] Khammari et al., 2011, Cell Death Differ. 18(5): 793--805 Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1. [FBrf0213412] Lee et al., 2011, J. Comp. Neurol. 519(1): 34--48 Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. [FBrf0212368] Li et al., 2011, Nat. Commun. 2: 408 Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. [FBrf0214630] Nakajima et al., 2011, Mol. Cell. Biol. 31(12): 2499--2512 Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila. [FBrf0213728] Ozdemir and Rawson, 2011, Fly 5(1): 3--6 Other ways to skin a cat: Activating SREBP without Scap. [FBrf0212974] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Shukla and Tapadia, 2011, Europ. J. Cell Biol. 90(1): 72--80 Differential localization and processing of apoptotic proteins in Malpighian tubules of Drosophila during metamorphosis. [FBrf0212365] Vandergaast et al., 2011, J. Virol. 85(16): 8348--8358 Active Depletion of Host Cell Inhibitor-of-Apoptosis Proteins Triggers Apoptosis upon Baculovirus DNA Replication. [FBrf0214468] Yuan et al., 2011, Structure 19(1): 128--140 Structure of the Drosophila apoptosome at 6.9 å resolution. [FBrf0212736] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...