FB2019_05, released Oct 15, 2019

Gene: Dmel\Drice

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General Information
Symbol
Dmel\Drice
Species
D. melanogaster
Name
Death related ICE-like caspase
Annotation Symbol
CG7788
Feature Type
protein_coding_gene
FlyBase ID
FBgn0019972
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
Ice, caspase-3
Key Links
Genomic Location
Cytogenetic map
99C1-99C1
Sequence location
3R:29,799,658..29,801,584 [+]
Recombination map
3-99
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase C14A family. (O01382)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
BIR domain binding; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis
Predictions / Assertions
cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process
Summaries
Gene Group (FlyBase)
CASPASES -
Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. (Adapted from FBrf0215539).
Protein Function (UniProtKB)
Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.
(UniProt, O01382)
Summary (Interactive Fly)
a effector caspase - activated during spermatogenesis and necessary for the removal of cytoplasm and the generation of functional sperm
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Drice or the JBrowse view of Dmel\Drice for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Drice-RA
FBtr0085482
NM_079827
1927
339
Additional Transcript Data and Comments
Reported size (kB)
1.02 (longest cDNA)
(Fraser and Evan, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Drice-PA
FBpp0084848
37.4
339
7.07
NP_524551
AAF56939
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
339 (aa)
(Fraser and Evan, 1997)
Comments
External Data
Subunit Structure (UniProtKB)
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Dronc and Drice can form a stable complex (PubMed:10675329). Interacts with Diap2 (via BIR3 domain) to form a stable complex (PubMed:18166655).
(UniProt, O01382)
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drice using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (18 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
BIR domain binding
inferred from physical interaction with FLYBASE:Diap2; FB:FBgn0015247
(Leulier et al., 2006)
inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635
(Leulier et al., 2006)
cysteine-type endopeptidase activity
inferred from direct assay
(Yeh and Bratton, 2013, Kanuka et al., 2005)
cysteine-type endopeptidase activity involved in apoptotic process
inferred from direct assay
(Ribeiro et al., 2007)
cysteine-type endopeptidase activity involved in execution phase of apoptosis
inferred from direct assay
(Yan et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cysteine-type endopeptidase activity
inferred from sequence or structural similarity with HGNC:1504
(Fraser and Evan, 1997)
inferred from sequence or structural similarity with HGNC:1507
(Fraser and Evan, 1997)
traceable author statement
(Brachmann and Cagan, 2003, Richardson and Kumar, 2002, Kumar and Doumanis, 2000, Tittel and Steller, 2000, Abrams, 1999)
cysteine-type endopeptidase activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000047947
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (13 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
neuron remodeling
inferred from mutant phenotype
(Schoenmann et al., 2010)
nurse cell apoptotic process
inferred from genetic interaction with FLYBASE:Dcp-1; FB:FBgn0010501
(Baum et al., 2007)
positive regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Leulier et al., 2006)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
inferred from direct assay
(Yan et al., 2004)
programmed cell death
inferred from mutant phenotype
(Muro et al., 2006)
inferred from direct assay
(Lee et al., 2011)
programmed cell death involved in cell development
inferred from mutant phenotype
(Kondo et al., 2006)
proteolysis
inferred from direct assay
(Yeh and Bratton, 2013)
response to X-ray
inferred from mutant phenotype
(Muro et al., 2006)
salivary gland histolysis
inferred from mutant phenotype
(Leulier et al., 2006)
spermatid differentiation
inferred from mutant phenotype
(Muro et al., 2006)
sterol regulatory element binding protein cleavage
inferred from direct assay
(Amarneh et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000047947
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Richardson and Kumar, 2002)
regulation of retinal cell programmed cell death
non-traceable author statement
(Brachmann and Cagan, 2003)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Martin and Baehrecke, 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000047947
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Fraser and Evan, 1997)
pupal stage
salivary gland
(Lee et al., 2003)
Additional Descriptive Data
The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.
(Lee et al., 2003)
Drice transcript is expressed in all developmental stages, with highest levels detected in 2-6 hr embryos.
(Fraser and Evan, 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
salivary gland
• cytoplasm
(Shukla and Tapadia, 2011)
Malpighian tubule
(Shukla and Tapadia, 2011)
prepupal stage P4 -- pupal stage P5
salivary gland
• cytoplasm

Comment: 10-14 hr APF; activated form

(Martin and Baehrecke, 2004)
prepupal stage P4(ii) -- pupal stage P5
salivary gland
• cytoplasm

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
Malpighian tubule

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
spermatogenesis & adult stage | male
spermatid cyst
• cytoplasm

Comment: preindividualized part of cyst

(Arama et al., 2003)
cystic bulge
(Arama et al., 2003)
waste bag
(Arama et al., 2003)
oogenesis stage S10 -- S12
nurse cell
• cytoplasm | punctate
(Peterson et al., 2003)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
salivary gland
(Shukla and Tapadia, 2011)
Malpighian tubule
(Shukla and Tapadia, 2011)
prepupal stage P4(ii) -- pupal stage P5
salivary gland

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
Malpighian tubule

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
Additional Descriptive Data
Processing of the full-length Drice precursor transcript (35 kDa) differs between pupal and larval salivary gland and Malpighian tubule tissue. Only the pupal salivary gland shows a band of fully activated Drice at 19 kDa.
(Shukla and Tapadia, 2011)
Drice protein detected by an antibody specific to the activated form is observed in the cytoplasm of salivary glands beginning at 10 hours APF. Levels increase with time, and activated Drice protein is abundant at 14 hours APF.
(Martin and Baehrecke, 2004)
Active Drice protein is observed to accumulate in the cytoplasm of preindividualized part of the spermatid cyst, and in the cystic bulge, but is not detectable in the postindividualized part of the spermatid cyst. Inactive Drice protein is observed uniformly in preindividualizing spermatid cysts.
(Arama et al., 2003)
An antibody thatspecifically recognizes the activated form of Drice was used to examine expression of this protein during apoptosis that occurs in nurse cells during oogenesis. Foci of activated Drice staining was first observed near nuclei of the nurse cells closest to the oocyte. Later, at stage 12, increased expression of Drice was observed in all nurse cells.
(Peterson et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Martin and Baehrecke, 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Drice in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Drice
Transgenic constructs containing regulatory region of Drice
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of pupal stage
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die (with Df(3R)Drice)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
male fertile
semi-sterile
Other Phenotypes
Allele
cell death defective
cell death defective, with Scer\GAL4Crz.504
cell death defective | drug conditional
cell death defective | somatic clone
chemical resistant, with Scer\GAL4ple.PF
decreased cell death
decreased cell death | adult stage
decreased cell death | adult stage, with Scer\GAL4CCAP.PP
decreased cell death | adult stage (with Drice17)
decreased cell death | adult stage (with DriceΔ1)
decreased cell death | embryonic stage
decreased cell death | pupal stage | somatic clone
developmental rate defective | partially | pupal stage
hyperplasia | larval stage | conditional, with Scer\GAL4ci.PU
increased cell death
increased cell death | P-stage
increased cell death | P-stage, with Scer\GAL4elav-C155
increased cell death | P-stage | recessive
neuroanatomy defective | adult stage
neuroanatomy defective | adult stage, with Scer\GAL4CCAP.PP
neuroanatomy defective | adult stage (with Drice17)
neuroanatomy defective | adult stage (with DriceΔ1)
radiation resistant
radiation resistant, with Scer\GAL4en-e16E
short lived
some die during embryonic stage
some die during larval stage
some die during pupal stage
some die during pupal stage, with Scer\GAL4pnr-MD237
tumorigenic | pupal stage
visible
visible, with DriceP10.GMR
visible, with DriceP20.GMR
wild-type
Phenotype manifest in
Allele
adult abdomen
adult optic lobe | P-stage
adult optic lobe | P-stage, with Scer\GAL4elav-C155
arista
dendrite, with Scer\GAL4ppk.PG
dendrite (with Drice17), with Scer\GAL4ppk.PG
dendrite (with DriceΔ1), with Scer\GAL4ppk.PG
eye
eye, with DriceP10.GMR
eye, with DriceP20.GMR
eye disc
eye disc | somatic clone
interommatidial precursor cell | pharate adult stage P9 | supernumerary, with Scer\GAL4GMR.PF
interommatidial precursor cell | pupal stage | supernumerary
male genitalia
male germline cell
midline glial cell
neuron
neuron, with Scer\GAL4Crz.504
neuron, with Scer\GAL4ppk.PG
neuron (with Drice17), with Scer\GAL4ppk.PG
neuron (with DriceΔ1), with Scer\GAL4ppk.PG
peptidergic neuron | adult stage | ectopic
peptidergic neuron | adult stage | ectopic, with Scer\GAL4CCAP.PP
peptidergic neuron | adult stage | ectopic (with Drice17)
peptidergic neuron | adult stage | ectopic (with DriceΔ1)
retina
retina | pupal stage | somatic clone
salivary gland | pupal stage, with Scer\GAL434B
spermatid cyst
spermatogonial cyst
wing
wing | somatic clone
wing disc
wing disc anterior compartment | conditional, with Scer\GAL4ci.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CASP7
13 of 15
Yes
Yes
Hsap\CASP3
11 of 15
No
Yes
 
Hsap\CASP6
6 of 15
No
Yes
Hsap\CFLAR
3 of 15
No
Yes
Hsap\CASP2
2 of 15
No
No
Hsap\CASP8
2 of 15
No
No
Hsap\CASP9
2 of 15
No
No
Hsap\CASP10
2 of 15
No
No
Hsap\CASP14
2 of 15
No
No
Hsap\CARD8
1 of 15
No
Yes
Hsap\CARD16
1 of 15
No
Yes
Hsap\CARD17
1 of 15
No
Yes
Hsap\CARD18
1 of 15
No
Yes
Hsap\CASP1
1 of 15
No
No
 
Hsap\CASP4
1 of 15
No
No
Hsap\CASP5
1 of 15
No
No
Hsap\PEA15
1 of 15
No
Yes
Hsap\PTCD1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Casp7
13 of 15
Yes
Yes
Mmus\Casp3
12 of 15
No
Yes
Mmus\Casp6
6 of 15
No
Yes
Mmus\Cflar
3 of 15
No
Yes
Mmus\Casp2
2 of 15
No
No
Mmus\Casp8
2 of 15
No
No
Mmus\Casp9
2 of 15
No
No
Mmus\Casp1
1 of 15
No
No
Mmus\Casp4
1 of 15
No
No
Mmus\Casp12
1 of 15
No
No
Mmus\Casp14
1 of 15
No
No
Mmus\Pea15a
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (13)
Rnor\Casp3
11 of 13
Yes
Yes
Rnor\Casp7
8 of 13
No
Yes
Rnor\LOC103689977
4 of 13
No
Yes
Rnor\Casp6
3 of 13
No
Yes
Rnor\Cflar
3 of 13
No
Yes
Rnor\Casp2
2 of 13
No
No
Rnor\Casp8
2 of 13
No
No
Rnor\Casp14
2 of 13
No
No
Rnor\Casp1
1 of 13
No
No
Rnor\Casp4
1 of 13
No
No
Rnor\Casp9
1 of 13
No
Yes
Rnor\Casp12
1 of 13
No
No
Rnor\Pea15
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\casp3
10 of 12
Yes
Yes
Xtro\casp7
7 of 12
No
Yes
Xtro\casp6
3 of 12
No
Yes
Xtro\casp2
2 of 12
No
No
Xtro\casp9
2 of 12
No
Yes
Xtro\LOC733553
2 of 12
No
No
Xtro\casp1
1 of 12
No
No
Xtro\casp10
1 of 12
No
No
Xtro\LOC100486222
1 of 12
No
Yes
Xtro\pea15
1 of 12
No
Yes
Danio rerio (Zebrafish) (26)
Drer\casp3a
12 of 15
Yes
Yes
Drer\casp3b
12 of 15
Yes
Yes
Drer\casp7
8 of 15
No
Yes
Drer\LOC100331324
7 of 15
No
Yes
Drer\casp6
5 of 15
No
Yes
Drer\casp6l2
3 of 15
No
Yes
Drer\casp8l1
3 of 15
No
No
Drer\cflara
3 of 15
No
Yes
Drer\LOC798445
3 of 15
No
No
Drer\LOC101886133
3 of 15
No
Yes
Drer\casp2
2 of 15
No
No
Drer\casp6l1
2 of 15
No
No
Drer\casp8
2 of 15
No
No
Drer\casp8l2
2 of 15
No
No
Drer\casp9
2 of 15
No
No
Drer\caspb
2 of 15
No
No
Drer\caspbl
2 of 15
No
No
Drer\caspxa
2 of 15
No
No
Drer\LOC795066
2 of 15
No
Yes
Drer\si:ch211-195h23.3
2 of 15
No
Yes
Drer\si:dkey-103e21.5
2 of 15
No
Yes
Drer\zgc:194469
2 of 15
No
Yes
Drer\caspa
1 of 15
No
No
Drer\gbp3
1 of 15
No
Yes
Drer\pea15
1 of 15
No
Yes
Drer\zgc:171731
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ced-3
9 of 15
Yes
Yes
 
Cele\csp-1
4 of 15
No
Yes
Cele\csp-2
3 of 15
No
Yes
Cele\csp-3
3 of 15
No
Yes
Cele\ZK795.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BE1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Drice
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008487
Drosophila simulans
Dsim\GD21467
Drosophila sechellia
Dsec\GM12823
Drosophila erecta
Dere\GG26440
Drosophila yakuba
Dyak\GE23886
Drosophila ananassae
Dana\GF18666
Drosophila pseudoobscura pseudoobscura
Dpse\GA20588
Drosophila persimilis
Dper\GL23515
Drosophila willistoni
Dwil\GK11928
Drosophila virilis
Dvir\GJ24096
Drosophila mojavensis
Dmoj\GI22043
Drosophila grimshawi
Dgri\GH19956
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503R7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012787
Musca domestica
House fly
Mdoa\17021485
Glossina morsitans
Tsetse fly
Gmor\GMOY005883
Glossina morsitans
Tsetse fly
Gmor\GMOY007347
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07925
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13466
Mayetiola destructor
Hessian fly
Mdes\Mdes002881
Aedes aegypti
Yellow fever mosquito
Aaeg\CASPS8
Anopheles darlingi
American malaria mosquito
Adar\ADAC006014
Anopheles darlingi
American malaria mosquito
Adar\ADAC004636
Anopheles gambiae
Malaria mosquito
Agam\CASPS7
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000671
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009056
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03JD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006946
Danaus plexippus
Monarch butterfly
Dple\DPOGS213029-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004700
Apis florea
Little honeybee
Aflo\4054857652
Apis mellifera
Western honey bee
Amel\LOC412235
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16697
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17823
Bombus terrestris
Buff-tailed bumblebee
Bter\15213364
Bombus terrestris
Buff-tailed bumblebee
Bter\15216186
Linepithema humile
Argentine ant
Lhum\LH17480
Linepithema humile
Argentine ant
Lhum\LH11162
Linepithema humile
Argentine ant
Lhum\LH11050
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002ec5
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b1f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d5a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010240
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010089
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010095
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12329
Tribolium castaneum
Red flour beetle
Tcas\TC003841
Pediculus humanus
Human body louse
Phum\PHUM536790
Pediculus humanus
Human body louse
Phum\PHUM221390
Rhodnius prolixus
Kissing bug
Rpro\RPRC003946
Rhodnius prolixus
Kissing bug
Rpro\RPRC011129
Cimex lectularius
Bed bug
Clec\CLEC006064
Cimex lectularius
Bed bug
Clec\CLEC001510
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003462
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004566
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001931
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003094
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13497
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17676
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14304
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18362
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03G0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010202
Strigamia maritima
European centipede
Smar\SMAR005942
Ixodes scapularis
Black-legged tick
Isca\ISCW013172
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82851.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82848.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02850
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g08820
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314077
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307426
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314078
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309162
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05YD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CspeN2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe8L4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe8L5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L1b2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CspeN5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023703gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe8L3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CspeN2a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001472gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007259gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe6L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe8L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe8L2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe3/7L
Ciona intestinalis
Vase tunicate
Cint\LOC100185724
Ciona intestinalis
Vase tunicate
Cint\LOC100175572
Ciona intestinalis
Vase tunicate
Cint\LOC100177955
Ciona intestinalis
Vase tunicate
Cint\LOC100185209
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024334
Ciona intestinalis
Vase tunicate
Cint\LOC494382
Ciona intestinalis
Vase tunicate
Cint\LOC100178691
Ciona intestinalis
Vase tunicate
Cint\LOC100183628
Gallus gallus
Domestic chicken
Ggal\CASP3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008346
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008240
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008305
Gallus gallus
Domestic chicken
Ggal\CASP6
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008355
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001366
Gallus gallus
Domestic chicken
Ggal\CASP2
Gallus gallus
Domestic chicken
Ggal\CASP7
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dcp-1
9 of 10
Decay
5 of 10
Dronc
4 of 10
Damm
3 of 10
Dredd
3 of 10
Strica
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
DriceΔ1
ameliorates  retinitis pigmentosa
modeled by ninaEP37H, ninaE17
(Griciuc et al., 2014)
DriceNIG.7788R
ameliorates  cancer
modeled by hidUAS.cUa, BacA\p35UAS.cHa
(Rudrapatna et al., 2013)
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CASP7; caspase 7
13 of 15
601761
      CASP3; caspase 3
      11 of 15
      600636
           
          CASP6; caspase 6
          6 of 15
          601532
              CFLAR; CASP8 and FADD like apoptosis regulator
              3 of 15
              603599
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Show neighbor-neighbor interactions:
                  Select Layout:
                  Legend:
                  Protein
                  RNA
                  Selected Interactor(s)
                  Interactions Browser
                  View in Interactions Browser
                  Please see the Physical Interaction reports below for full details
                  RNA-RNA
                  Physical Interaction
                  Assay
                  References
                  Drice - mir-14
                  western blot
                  (Xu et al., 2003)
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  Drice - Akt1
                  anti tag coimmunoprecipitation, Identification by mass spectrometry
                  (Vinayagam et al., 2016)
                  Drice - CG3793
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Drice - Coq6
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Drice - Dcp-1
                  enzymatic study, autoradiography, western blot
                  (Choutka et al., 2017, DeVorkin et al., 2014)
                  Drice - Diap1
                  anti tag coimmunoprecipitation, western blot, anti tag western blot, pull down
                  (Huang et al., 2014, Ditzel et al., 2008, Leulier et al., 2006, Tenev et al., 2005)
                  Drice - Diap2
                  anti tag coimmunoprecipitation, western blot
                  (Ribeiro et al., 2007, Leulier et al., 2006)
                  Drice - Dronc
                  cleavage assay, autoradiography, enzymatic study, molecular weight estimation by staining, anti tag western blot
                  (Pang et al., 2015, D'Brot et al., 2013, Yang et al., 2010, Dorstyn and Kumar, 2008, Snipas et al., 2008)
                  Drice - Hsap\PARP1
                  enzymatic study, western blot
                  (Ditzel et al., 2008)
                  Drice - ICA69
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Drice - Idh3b
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Drice - Lapsyn
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Drice - Nedd8
                  anti bait coimmunoprecipitation, western blot
                  (Broemer et al., 2010)
                  Drice - Teh1
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Drice - Ubr3
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Huang et al., 2014)
                  Drice - tmod
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Drice|Diap1
                  suppressible
                  Damm|Dcp-1|Decay
                  (Leulier et al., 2006)
                  Drice|hid
                  suppressible
                  Dcp-1
                  (Leulier et al., 2006)
                  Drice
                  enhanceable
                  Dcp-1
                  (Muro et al., 2006, Xu et al., 2006)
                  Drice
                  enhanceable
                  rpr
                  (Song et al., 2000)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Diap1
                  suppressible
                  Drice
                  (Leulier et al., 2006, Muro et al., 2006)
                  grim
                  suppressible
                  Drice
                  (Muro et al., 2006)
                  hid
                  suppressible
                  Drice
                  (Wu et al., 2016, Rudrapatna et al., 2013, Kondo et al., 2006, Leulier et al., 2006, Muro et al., 2006, Xu et al., 2006)
                  hid
                  suppressible
                  Dcp-1|Drice
                  (Leulier et al., 2006)
                  ninaE
                  suppressible
                  Drice
                  (Griciuc et al., 2014)
                  nos
                  suppressible
                  Drice
                  (Bhogal et al., 2016)
                  rpr
                  suppressible
                  Drice
                  (Wu et al., 2016, Muro et al., 2006, Xu et al., 2006)
                  rpr
                  enhanceable
                  Drice
                  (Wu et al., 2016)
                  S2P
                  suppressible
                  Drice
                  (Amarneh et al., 2009)
                  External Data
                  Subunit Structure (UniProtKB)
                  Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Dronc and Drice can form a stable complex (PubMed:10675329). Interacts with Diap2 (via BIR3 domain) to form a stable complex (PubMed:18166655).
                  (UniProt, O01382 )
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3R
                  Recombination map
                  3-99
                  Cytogenetic map
                  99C1-99C1
                  Sequence location
                  3R:29,799,658..29,801,584 [+]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  99C1-99C1
                  Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location
                  3-99
                  (FlyBase, 2016)
                  3-97.0
                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (6)
                  Genomic Clones (17)
                   

                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                  cDNA Clones (71)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequences
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  polyclonal
                  (Yeh and Bratton, 2013, Lannan et al., 2007)
                  polyclonal antibody CM1
                  (Arama et al., 2003)
                  Commercially Available Antibodies
                   
                  Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for identity of: Drice Ice
                  (Steller et al., 2014.7.9)
                  Source for database merge of
                  Additional comments
                  Changed from 'Ice' to 'Drice' to reflect common usage in the literature.
                  (Steller et al., 2014.7.9)
                  The Ice gene may have been derived from the Dcp-1 gene by retroposition.
                  (Langille and Clark, 2007)
                  Other Comments
                  Ice is activated in wing discs after irradiation.
                  (Florentin and Arama, 2012)
                  th blocks effector caspases by targeting them for polyubiquitylation and nonproteasomal inactivation.
                  (Ditzel et al., 2008)
                  Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
                  (Liu and Lehmann, 2008)
                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                  (Kiger et al., 2003)
                  A CED-4-like P-loop-containing ATPase is involved in the activation of Ice to promote the cell death program in Drosophila.
                  (Kanuka et al., 1999)
                  Overexpression of Ice sensitizes cells to apoptotic stimuli and expression of an N-terminally truncated form rapidly induces apoptosis. Ice is a Cys protease that cleaves baculovirus p35 and Lam in vitro and Ice is expressed at all stages of development at which programmed cell death can be induced. These results strongly suggest that Ice is an apoptotic caspase that acts downstream of rpr.
                  (Fraser and Evan, 1997)
                  Ice encodes an essential caspase required for apoptotic activity in Drosophila cells.
                  (Fraser et al., 1997)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 62 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
                  modMine - A data warehouse for the modENCODE project
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                  Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                  DPiM - Drosophila Protein interaction map
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (17)
                  Reported As
                  Symbol Synonym
                  CG7788
                  (Ni et al., 2010.12.1, Sun et al., 2010, Wagner et al., 2009, Pal et al., 2007, Lee et al., 2003, Irving et al., 2001)
                  DRICE
                  (Ziraldo and Ma, 2015, Shukla and Tapadia, 2011, Gupta et al., 2010, Dorstyn and Kumar, 2008, Khan et al., 2008, Snipas et al., 2008, Daish et al., 2004, Dorstyn et al., 2004, Huh et al., 2004, Arama et al., 2003, Ilangovan et al., 2003, Morey et al., 2003, Morey et al., 2003, Dorstyn et al., 2002, Muro et al., 2002, Harvey et al., 2001)
                  DrICE
                  (McSharry and Beitel, 2019, Diwanji and Bergmann, 2018, Dorstyn et al., 2018, Diwanji and Bergmann, 2017, Nainu et al., 2017, Nakajima and Kuranaga, 2017, Wang et al., 2017, Dabrowska et al., 2016, Eroglu and Derry, 2016, Kawamoto et al., 2016, Koerver et al., 2016, Huang et al., 2014, Tamori and Deng, 2014, Christiansen et al., 2013, Yeh and Bratton, 2013, Filipiak et al., 2012, Kuranaga, 2011, Vandergaast et al., 2011, Yuan et al., 2011, Mallik and Lakhotia, 2009, Fan and Bergmann, 2008, Settles and Friesen, 2008, Challa et al., 2007, Fan and Bergmann, 2007, Herman-Bachinsky et al., 2007, Kuranaga and Miura, 2007, Lannan et al., 2007, Means et al., 2006, Kornbluth and White, 2005, Xu et al., 2005, Shiozaki and Shi, 2004, Yan et al., 2004, Yin and Thummel, 2004, Hawkins et al., 1999)
                  DrIce
                  (Muzzopappa et al., 2017, McPhee et al., 2013, Yuan and Akey, 2013, Rives et al., 2006, Singh and Choi, 2006, Baehrecke, 2000)
                  Drice
                  (Bozler et al., 2019, Meltzer et al., 2019, Pinal et al., 2019, Ahmed-de-Prado and Baonza, 2018, Chi et al., 2018, Xu et al., 2018, Choutka et al., 2017, Khan et al., 2017, Macedo et al., 2017, Schott et al., 2017, Tavignot et al., 2017, Transgenic RNAi Project members, 2017-, Bhogal et al., 2016, Chen et al., 2016, Eroglu and Derry, 2016, Melzer and Broemer, 2016, Zheng et al., 2016, Arya and White, 2015, Denton and Kumar, 2015, Dwivedi et al., 2015, Means et al., 2015, Nicolson et al., 2015, Sakamaki et al., 2015, Su, 2015, Zimmermann et al., 2015, DeVorkin et al., 2014, Liu et al., 2014, Steller et al., 2014.7.9, D'Brot et al., 2013, Denton et al., 2013, Dick and Megeney, 2013, Lee et al., 2013, Rudrapatna et al., 2013, Tran et al., 2013, Fabian and Brill, 2012, Florentin and Arama, 2012, Marchal et al., 2012, Miura, 2012, Verghese et al., 2012, Keller et al., 2011, Miura, 2011, Morata et al., 2011, Chew et al., 2009, Liu et al., 2009, Ribaya et al., 2009, Umemori et al., 2009, Bardet et al., 2008, Biteau et al., 2008, Guha et al., 2008, Li and Cadigan, 2008, Pret et al., 2008, Agnès et al., 2007, Chew et al., 2007, Copeland et al., 2007, Guan et al., 2007, Huh et al., 2007, Primrose et al., 2007, Sato et al., 2007, Baehrecke, 2006, Lee et al., 2006, Montell, 2006, Singh et al., 2006, Vidal and Cagan, 2006, Baum et al., 2005, Cabernard and Affolter, 2005, Lee et al., 2005, Perez-Garijo et al., 2005, Singh and Choi, 2005, Wienholds and Plasterk, 2005, Gendre et al., 2004, Hanyu-Nakamura et al., 2004, Hay et al., 2004, He and Hannon, 2004, Huh et al., 2004, Martin and Baehrecke, 2004, Moreno and Basler, 2004, Muro et al., 2004, Sen et al., 2004, Xu et al., 2004, Ambros, 2003, Anonymous, 2003, Baehrecke, 2003, Baehrecke, 2003, Brachmann and Cagan, 2003, Cagan, 2003, Claveria and Torres, 2003, Jia et al., 2003, Lawen, 2003, Lee et al., 2003, Peterson et al., 2003, Udan et al., 2003, Van Hoof and Goris, 2003, Xu et al., 2003, Adams and Cory, 2002, Gorski and Marra, 2002, Kango-Singh et al., 2002, Li et al., 2002, Richardson and Kumar, 2002, Tapon et al., 2002, Yoo et al., 2002, Yu et al., 2002, Adams and Cory, 2001, Yu et al., 2001, Kumar, 2000, Vernooy et al., 2000, Abrams, 1999)
                  Drive
                  (Chen et al., 2012)
                  ICE
                  (Ertürk-Hasdemir et al., 2009, Hoffmann, 2003)
                  Ice
                  (Mondal et al., 2018, Fallahi et al., 2016, Appocher et al., 2014, dos Santos, 2014, Griciuc et al., 2014, Kim et al., 2014, Robbins et al., 2014, Japanese National Institute of Genetics, 2012.5.21, McGurk and Bonini, 2012, Friedman et al., 2011, Seong et al., 2011, Sun et al., 2010, Liu et al., 2009, Wagner et al., 2009, Hou et al., 2008, Liu and Lehmann, 2008, Nusinow et al., 2008, Langille and Clark, 2007, Zeitouni et al., 2007, Zhong and Belote, 2007, Muro et al., 2006, Chan et al., 2005, Kim et al., 2005)
                  caspase 3
                  (Wichmann et al., 2006)
                  crice
                  (Zeitouni et al., 2007)
                  drICE
                  (Pérez et al., 2017, Orme et al., 2016, Wu et al., 2016, Akagawa et al., 2015, Di Cara et al., 2015, Enomoto et al., 2015, Nainu et al., 2015, Ortega-Arellano et al., 2013, Yang et al., 2013, Li et al., 2011, Broemer et al., 2010, Fan and Bergmann, 2010, Yang et al., 2010, Creagh et al., 2009, Ertürk-Hasdemir et al., 2009, Kessler and Müller, 2009, Lee et al., 2009, Xu et al., 2009, Bardet et al., 2008, Ditzel et al., 2008, Fan and Bergmann, 2008, Xu and Bergmann, 2008, Arama et al., 2007, Kim and Yoo, 2007, Luque and Milan, 2007, Ribeiro et al., 2007, Ribeiro et al., 2007, Shin and Yoo, 2007, Tenev et al., 2007, Xu and Bergmann, 2007, Arama et al., 2006, Mendes et al., 2006, Wichmann et al., 2006, Xu et al., 2006, Xu et al., 2006, Arama and Steller, 2005, Tenev et al., 2005, Arama and Steller, 2004, Igaki and Miura, 2004, Kessler and Müller, 2004, Manaka et al., 2004, Bergmann and Lane, 2003, Bergmann et al., 2003, Ditzel et al., 2003, Kessler and Muller, 2003, Olson et al., 2003, Zachariou et al., 2003, Igaki et al., 2002, Jabbour et al., 2002, Huh et al., 2001, Bangs et al., 2000, Bialik and Gottlieb, 2000, Hawkins et al., 2000, Meier et al., 2000, Meier et al., 2000, Song et al., 2000, Tittel and Steller, 2000, Vernooy et al., 2000, White, 2000, Yokoyama et al., 2000, Bergmann et al., 1999, Deveraux and Reed, 1999, Dorstyn et al., 1999, Kanuka et al., 1999, Kanuka et al., 1999, McNeill and Downward, 1999, Miller, 1999, Rodriguez et al., 1999, Wang et al., 1999, White, 1999, Zhou et al., 1999, Bergmann et al., 1998, Kaiser et al., 1998, Fraser and Evan, 1997, Fraser et al., 1997, McCall and Steller, 1997)
                  drIce
                  (Leulier et al., 2006)
                  drice
                  (Robin et al., 2019, Borensztejn et al., 2018, Kang et al., 2017, Lu et al., 2017, Means et al., 2015, Wang and Baker, 2015, Zhang et al., 2015, Liang et al., 2014, Denton et al., 2013, Lee et al., 2013, Yacobi-Sharon et al., 2013, Chandrasekhar et al., 2012, Khammari et al., 2011, Ozdemir and Rawson, 2011, Matthews et al., 2010, Schoenmann et al., 2010, Sharma and Fitzgerald, 2010, Amarneh et al., 2009, Denton et al., 2009, Denton et al., 2008, Baum et al., 2007, Link et al., 2007, McCall et al., 2007, Herranz et al., 2006, Kondo et al., 2006, Kilpatrick et al., 2005, Kondo et al., 2005, Zheng et al., 2005, Cakouros et al., 2004, Kumar and Cakouros, 2004, McCall, 2004, Kumar et al., 2003, Lai, 2003, Kumar and Doumanis, 2000)
                  ice
                  (Mondal et al., 2017, Lee et al., 2013, Lee et al., 2011, Pal et al., 2007, Fraser, 1997.4.3)
                  Name Synonyms
                  Death related ICE-like caspase
                  (Steller et al., 2014.7.9)
                  Drice
                  (Koch et al., 2009, Chandraratna et al., 2007, Umemori et al., 2007, Sprecher and Hirth, 2006)
                  Ice
                  (Zeitouni et al., 2007)
                  caspase-3
                  (Griciuc et al., 2014, Gupta et al., 2010, Mallik and Lakhotia, 2009, Primrose et al., 2007)
                  interleukin-1β-converting enzyme
                  (Khan et al., 2008)
                  Secondary FlyBase IDs
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                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (354)