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Gene Dmel\mGluRA

General Information
Symbol	Dmel\mGluRA	Species	D. melanogaster
Name	metabotropic glutamate receptor	Annotation symbol	CG11144
Feature type	protein_coding_gene	FlyBase ID	FBgn0019985
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	DmGluRA, mGluR
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102F1-102F3	Sequence location	4:957,445..967,451 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene metabotropic glutamate receptor is referred to in FlyBase by the symbol Dmel\mGluRA (CG11144, FBgn0019985). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cholesterol binding; glutamate binding. There is experimental evidence that it is involved in the biological process: regulation of synaptic transmission, glutamatergic; neuromuscular junction development. 11 alleles are reported. The phenotypes of these alleles are annotated with: bouton; type I bouton. It has one annotated transcript and one annotated polypeptide. Protein features are: Extracellular ligand-binding receptor; GPCR, family 3; GPCR, family 3, C-terminal; GPCR, family 3, conserved site; GPCR, family 3, metabotropic glutamate receptor; GPCR, family 3, nine cysteines domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1639492_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mGluRA. Gene sequence location is 4:957445..967451.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN22336 HFA17215
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102F1-102F3
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102C-102D     (Parmentier, 1996.7.31) 102C-102D   (determined by in situ hybridisation)   (Parmentier et al., 1996)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mGluRA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mGluRA-RA FBtr0089184  NM_079900   3345   976
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mGluRA-PA   FBpp0088248   108.5   976   7.26     NP_524639   AAF59402
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GPCR, family 3, C-terminal (IPR017978) GPCR, family 3, conserved site (IPR017979) GPCR, family 3, metabotropic glutamate receptor (IPR000162) GPCR, family 3 (IPR000337) Extracellular ligand-binding receptor (IPR001828) GPCR, family 3, nine cysteines domain (IPR011500)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014135 AAF59402   AC010838   AC010916   BT025152   BT088899   CO186988   CO190111   CO264984   CO270435   CO271306   CO299913   CO300506   CO333909   CO343809   CO344246   EC051216   EC053232   EC054222   EC054743   EC055858   EC070946   EC090803   EC194920   EC205064   EC219777   EC220421   EC221655   EL871058   EL871294   EL871295   X99675 CAA67993
UniProtKB/Swiss-Prot	P91685
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval brain   (Ramaekers et al., 2001) embryonic/larval deuterocerebrum   (Ramaekers et al., 2001) embryonic/larval optic lobe   (Ramaekers et al., 2001) embryonic/larval subesophageal ganglion   (Ramaekers et al., 2001) adult stage   adult antennal lobe glomerulus   (Ramaekers et al., 2001) local interneuron of adult antennal lobe   (Ramaekers et al., 2001) optic lobe   (Ramaekers et al., 2001) medulla   (Ramaekers et al., 2001, Kolodziejczyk et al., 2008) lobula   (Ramaekers et al., 2001) adult tritocerebrum   (Ramaekers et al., 2001) adult central complex   (Ramaekers et al., 2001) fan-shaped body   (Ramaekers et al., 2001) metathoracic neuromere   (Ramaekers et al., 2001) abdominal neuromere   (Ramaekers et al., 2001) lobula complex   (Kolodziejczyk et al., 2008)
Additional Descriptive Data
	There are fourteen mGluRA immunopositive cell bodies are found in the third instar larval brain. Expression of mGlu</up>RA is detected in the dorsal and ventral aspect of the adult fan-shaped body of the central complex. Three neurons of the metathoracic neuromere, and four pairs of neurons in the abdominal neuromere are mGluRA immunopositive. (Ramaekers et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0019985    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0019985 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0019985 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr  (135) embryo 18-20hr  (120) embryo 20-22hr  (129) embryo 22-24hr  (221) larva L1  (152) larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr  103 white prepupae 24hr  (160) pupae 2d postWPP  (255) pupae 3d postWPP  (214) pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0019985 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr  135 embryo 18-20hr  120 embryo 20-22hr  129 embryo 22-24hr  (221) larva L1  (152) larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr  103 white prepupae 24hr  (160) pupae 2d postWPP  (255) pupae 3d postWPP  (214) pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    26 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    21 embryo 12-14hr    54 embryo 14-16hr    64 embryo 16-18hr    135 embryo 18-20hr    120 embryo 20-22hr    129 embryo 22-24hr    221 larva L1    152 larva L2    79 larva L3 12hr old    21 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    68 white prepupae new    69 white prepupae 12hr    103 white prepupae 24hr    160 pupae 2d postWPP    255 pupae 3d postWPP    214 pupae 4d postWPP    41 adult male 01day    83 adult male 05day    73 adult male 30day    67 adult female 01day    30 adult female 05day    14 adult female 30day    12 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0019985    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0019985 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0019985 expression level Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0019985 expression level Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.625 Larval Midgut    7.6 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    3.3 Larval Trachea    1.225 Larval Carcass    5.15 Adult Head    13.1 Adult Eye    3.625 Adult Brain    75.7 Adult Thoracic-Abdominal Ganglion    44.5 Adult Crop    5.7 Adult Midgut    6.7 Adult Hindgut    4.4 Adult Malpighian Tubules    3.3 Adult Fat Body    7.2 Adult Salivary Gland    6.2 Adult Heart    3.175 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    5.2 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    3.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    13.1   NA  Eye    3.625   NA  Brain    75.7   14.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    44.5   NA  Crop    5.7   7.6  Midgut    6.7   3.7  Hindgut    4.4   4.6  Malpighian Tubules    3.3   6.8  Fat Body    7.2   3.3  Salivary Gland    6.2   NA  Heart    3.175   1.225  Trachea    NA   NA  VirginFemale Spermatheca    4.3   NA  InseminatedFemale Spermatheca    5.2   NA  Ovary    1.2   NA  Testis    2.7   NA  Male Accessory Gland    3.6   5.15  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019985 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11144-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mGluRA112b viable, with Scer\GAL4pnr-MD237 mGluRAGD707 Other Phenotypes Allele neuroanatomy defective mGluRA112b neuroanatomy defective, with Scer\GAL4BG380 mGluRAScer\UAS.cRa neuroanatomy defective, with Scer\GAL4OK6 mGluRAScer\UAS.cRa neuroanatomy defective | recessive mGluRA112b neurophysiology defective mGluRA112b neurophysiology defective, with Scer\GAL4BG380 mGluRAdsRNA.Scer\UAS neurophysiology defective (with Df(4)O2) mGluRA112b Phenotype manifest in Allele bouton mGluRA112b bouton | supernumerary, with Scer\GAL4BG380 mGluRAScer\UAS.cRa bouton | supernumerary, with Scer\GAL4OK6 mGluRAScer\UAS.cRa type I bouton mGluRA112b type I bouton, with Scer\GAL4BG380 mGluRAdsRNA.Scer\UAS type I bouton (with Df(4)O2) mGluRA112b
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of mGluRA Class Mutagen Stocks Known lesion mGluRAMI02169 1 -- mGluRANP6701 1 -- mGluRA112b loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mGluRA Class Mutagen Stocks Known lesion mGluRAGD707 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mGluRAHMS00191 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mGluRAJF01958 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mGluRAKK102270 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mGluRAdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes mGluRAScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes mGluRAScer\UAS.T:Avic\GFP-EGFP.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mGluRAScer\UAS.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD707} NA P{KK102270} NA P{TRiP.HMS00191} NA P{TRiP.JF01958} NA P{UAS-mGluRA.His6} NA P{UAS-mGluRA.RNAi} NA P{UAS-mGluRA-GFP-His6} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}mGluRANP6701 No miscellaneous insertions Mi{MIC}mGluRAMI02169 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
cholesterol binding inferred from direct assay (Eroglu et al., 2003) glutamate binding inferred from direct assay (Eroglu et al., 2003)
Biological Process
CV term Evidence References
neuromuscular junction development inferred from mutant phenotype (Bogdanik et al., 2004) regulation of synaptic transmission, glutamatergic inferred from mutant phenotype (Bogdanik et al., 2004)
Cellular Component
CV term Evidence References
membrane raft inferred from direct assay (Eroglu et al., 2003) plasma membrane inferred from direct assay (Eroglu et al., 2003)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
glutamate receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) non-traceable author statement (Ramaekers et al., 1997, Parmentier, 1996.7.31) G-protein coupled receptor activity inferred from electronic annotation with InterPro:IPR000337, InterPro:IPR011500, InterPro:IPR017978, InterPro:IPR017979 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Radford et al., 2002)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000162, InterPro:IPR000337, InterPro:IPR011500, InterPro:IPR017978, InterPro:IPR017979 (FlyBase Curators et al., 2004-) metabotropic glutamate receptor signaling pathway inferred from sequence or structural similarity (Brody and Cravchik, 2000)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000162, InterPro:IPR000337, InterPro:IPR017978, InterPro:IPR017979 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000) integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1998.2.1) plasma membrane non-traceable author statement (Parmentier, 1996.7.31)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mGluRA allele Gene References unspecified Gβ13F (Bogdanik et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68663 DroID - A comprehensive database of gene and protein interactions. • FBgn0019985 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43838
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19012 Dere\GG16401 Dgri\GH23961 Dmoj\GI14041 Dper\GL17542 Dpse\GA22410 Dsec\GM26815 Dvir\GJ13080 Dwil\GK13663 Dyak\GE14562
Curated drosophilid orthologs	Dpse\GA10792
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • NP_001011624.1 Apis mellifera (honey bee) XP_001952249.1 Acyrthosiphon pisum (pea aphid) 194026 Branchiostoma floridae (lancelet) XP_001898444.1 Brugia malayi (roundworm nematode) BGIBMGA011259-PA Bombyx mori (silk worm) ENSBTAP00000025275 Bos taurus (bovine) CN19168 Caenorhabditis brenneri (small nematode) CBP00515 Caenorhabditis briggsae (nematode) CE01682 Caenorhabditis elegans (worm) ENSCAFP00000002613 Canis familiaris (dog) ENSCINP00000004255 Ciona intestinalis (sea squirt) JA03253 Caenorhabditis japonica (nematode) CPIJ008111 Culex pipens (mosquito) ENSCPOP00000012413 Cavia porcellus (guinea pig) RP28149 Caenorhabditis remanei (nematode) 211789 Capitella spl (polychaete worm) 44069 Daphnia pulex (daphnia) ENSDARP00000047308 Danio rerio (zebra fish) ENSECAP00000006741 Equus caballus (horse) ENSGACP00000016828 Gymnopilus aculeatus (mushroom) ENSGALP00000010610 Gallus gallus (chicken) 79942 Hypsipyla robusta (cedar shoot borer) ENSP00000355316 Homo sapiens (human) ISCW013154-PA Ixodes scapularis (deer tick) 130830 Lottia gigantea (owl limpet) ENSMODP00000021158 Monodelphis domestica (gray opossum) ENSMMUP00000029633 Macaca mulatta (rhesus monkey) ENSMUSP00000004076 Mus musculus (house mouse) 229374 Nematostella vectensis (starlet anemone) ENSOANP00000009192 Ornithorynchus anatinus (platypus) ENSORLP00000011816 Oryzias latipes (japanese killifish) PHUM004939-PA Pediculus humanus (human body louse) PP12897 Pristionchus pacificus (nematode) ENSPPYP00000020006 Pongo pygmaeus (orangutan) ENSPTRP00000033113 Pan troglodytes (chimpanzee) ENSRNOP00000007572 Rattus norvegicus (norway rat) XP_001194117.1 Strongylocentrotus purpuratus (purple sea urchin) 11098 Trichoplax adhaerens (metazoa) 25549 Trichoplax adhaerens (metazoa) XP_972407.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022399 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036431 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000011950 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18252 PB18253 LH22634 ISCW016808 FBgn0232161 FBgn0215671 FBgn0200308 FBgn0181666 FBgn0167951 JGI_V11_44069 FBgn0243817 FBgn0155145 FBgn0136795 FBgn0131418 FBgn0108633 FBgn0096024 FBgn0096023 GB18621 GLEAN_04727
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	32830 y1; Mi{MIC}mGluRAMI02169 25938 y1 v1; P{TRiP.JF01958}attP2 34872 y1 sc* v1; P{TRiP.HMS00191}attP2
Kyoto	105323 w*; P{GawB}mGluRANP6701
VDRC	v103736 P{KK102270}VIE-260B v1793 w1118; P{GD707}v1793 v1794 w1118; P{GD707}v1794
Genomic Clones ( 3 )
	BACR11A04 BACR13D24 BACR16N23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03518
Other clones	IP03318
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	31448 194634 282712 CK01.26B.E12 CK01.109B.E4 CK01.168A.G2 EC051216 EC053232 EC054222 EC054743 EC055858 EK025139 EK046602 EK098850 EK102943 EK141133 EK176912 EK178401 EK308316 EP18103 EP18926 IP03218 IP03418
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0019985 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43838
Antibody Information
	polyclonal (Generated in rabbit against the C-terminal peptide sequence EFLPEVGERVEPI corresponding to residues 958-969.) (Ramaekers et al., 2001)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	When co-expressed in Xenopus oocytes with a mammalian G-protein coupled inwardly rectifying potassium channel protein the Glu-RA protein activates an inwardly rectifying potassium current. (Raymond et al., 1999) Encodes a G protein-coupled metabotropic glutamate receptor. (Grau et al., 1997) Glu-RA is expressed in the adult and in the CNS of late embryos. (Parmentier et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079900 RefSeq (Proteins) • NP_524639 DDBJ / EMBL / GenBank • AAF59402 AC010838 AC010916 CAA67993 X99675 Entrez Gene - A searchable database of RefSeq genes. • 43838 UniProtKB/Swiss-Prot • P91685
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GPCR, family 3, C-terminal (IPR017978) GPCR, family 3, conserved site (IPR017979) GPCR, family 3, metabotropic glutamate receptor (IPR000162) GPCR, family 3 (IPR000337) Extracellular ligand-binding receptor (IPR001828) GPCR, family 3, nine cysteines domain (IPR011500)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68663 DroID - A comprehensive database of gene and protein interactions. • FBgn0019985 DRSC - Results from RNAi screens. • FBgn0019985 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019985 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11144-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0019985 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43838 InParanoid A subset of ortholog calls from InParanoid. • NP_001011624.1 Apis mellifera (honey bee) XP_001952249.1 Acyrthosiphon pisum (pea aphid) 194026 Branchiostoma floridae (lancelet) XP_001898444.1 Brugia malayi (roundworm nematode) BGIBMGA011259-PA Bombyx mori (silk worm) ENSBTAP00000025275 Bos taurus (bovine) CN19168 Caenorhabditis brenneri (small nematode) CBP00515 Caenorhabditis briggsae (nematode) CE01682 Caenorhabditis elegans (worm) ENSCAFP00000002613 Canis familiaris (dog) ENSCINP00000004255 Ciona intestinalis (sea squirt) JA03253 Caenorhabditis japonica (nematode) CPIJ008111 Culex pipens (mosquito) ENSCPOP00000012413 Cavia porcellus (guinea pig) RP28149 Caenorhabditis remanei (nematode) 211789 Capitella spl (polychaete worm) 44069 Daphnia pulex (daphnia) ENSDARP00000047308 Danio rerio (zebra fish) ENSECAP00000006741 Equus caballus (horse) ENSGACP00000016828 Gymnopilus aculeatus (mushroom) ENSGALP00000010610 Gallus gallus (chicken) 79942 Hypsipyla robusta (cedar shoot borer) ENSP00000355316 Homo sapiens (human) ISCW013154-PA Ixodes scapularis (deer tick) 130830 Lottia gigantea (owl limpet) ENSMODP00000021158 Monodelphis domestica (gray opossum) ENSMMUP00000029633 Macaca mulatta (rhesus monkey) ENSMUSP00000004076 Mus musculus (house mouse) 229374 Nematostella vectensis (starlet anemone) ENSOANP00000009192 Ornithorynchus anatinus (platypus) ENSORLP00000011816 Oryzias latipes (japanese killifish) PHUM004939-PA Pediculus humanus (human body louse) PP12897 Pristionchus pacificus (nematode) ENSPPYP00000020006 Pongo pygmaeus (orangutan) ENSPTRP00000033113 Pan troglodytes (chimpanzee) ENSRNOP00000007572 Rattus norvegicus (norway rat) XP_001194117.1 Strongylocentrotus purpuratus (purple sea urchin) 11098 Trichoplax adhaerens (metazoa) 25549 Trichoplax adhaerens (metazoa) XP_972407.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022399 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036431 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000011950 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43838 modMine - Data generated by the modENCODE project. • FBgn0019985 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18252 PB18253 LH22634 ISCW016808 FBgn0232161 FBgn0215671 FBgn0200308 FBgn0181666 FBgn0167951 JGI_V11_44069 FBgn0243817 FBgn0155145 FBgn0136795 FBgn0131418 FBgn0108633 FBgn0096024 FBgn0096023 GB18621 GLEAN_04727
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CAA67993.1_Dr (Yu et al., 2004) CG11144 (Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmGluAR (Parmentier et al., 2000) DmGlu-A (Ramaekers et al., 2001) DmGluA (Mitri et al., 2009) DmGluAR (Mitri et al., 2004) DmGluR (Locke et al., 2000) DmGluRA (Mezler et al., 2001) DmGluRA (Diagana et al., 2002, Ramaekers et al., 2001, Vanden Broeck, 2001, Raymond et al., 1999, Parmentier et al., 1997, Parmentier et al., 1997, Ramaekers et al., 1997, Grau et al., 1997, Parmentier et al., 1996, Kolodziejczyk et al., 2008, Dolen and Bear, 2005, McBride et al., 2005, Pan et al., 2008, Howlett et al., 2008, Bogdanik et al., 2004, Panneels et al., 2011, Eroglu et al., 2003, Eroglu et al., 2002, Devaud et al., 2008, McBride et al., 2010, Chun-Jen Lin et al., 2011) dmGluRA (Bhogal and Jongens, 2006, Pan and Broadie, 2007, Repicky and Broadie, 2009) DmGlu-RA (Pan and Broadie, 2007) GluR (Kolodziejczyk et al., 2008) Glu-RA   mGluR (Pan and Broadie, 2007, Repicky and Broadie, 2009, Chun-Jen Lin et al., 2011, Nishikawa and Kidokoro, 1999) mGluRA (Grosjean et al., 2008)
Name Synonym	metabotropic glutamate receptor (Parmentier, 1996.7.31, Pan and Broadie, 2007, Parmentier et al., 1996, Pan et al., 2008, Eroglu et al., 2002, Kolodziejczyk et al., 2008, McBride et al., 2010) Metabotropic glutamate receptor   Metabotropic Glutamate Receptor (Chun-Jen Lin et al., 2011)
Secondary FlyBase IDs
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 3 ) Review  ( 4 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Chun-Jen Lin et al., 2011, Genetics 188(3): 601--613 The Metabotropic Glutamate Receptor Activates the Lipid Kinase PI3K in Drosophila Motor Neurons Through the Calcium/Calmodulin-Dependent Protein Kinase II and the Nonreceptor Tyrosine Protein Kinase DFak. [FBrf0214227] Panneels et al., 2011, PLoS ONE 6(4): e18478 Drosophila photoreceptor cells exploited for the production of eukaryotic membrane proteins: receptors, transporters and channels. [FBrf0213462] McBride et al., 2010, J. Neurosci. 30(28): 9510--9522 Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. [FBrf0211297] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...