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General Information
Symbol
Dmel\Fab-7
Species
D. melanogaster
Name
Fab-7
Annotation Symbol
Feature Type
FlyBase ID
FBgn0020011
Gene Model Status
Stock Availability
Also Known As

Frontabdominal-7, Fab-7 PRE

Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Molecular Function (GO)
    [Detailed GO annotations]
    Experimental Evidence
    -
    Predictions / Assertions
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fab-7 using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Gene Ontology (0 terms)
      Molecular Function (0 terms)
      Terms Based on Experimental Evidence (0 terms)
      Terms Based on Predictions or Assertions (0 terms)
      Biological Process (0 terms)
      Terms Based on Experimental Evidence (0 terms)
      Terms Based on Predictions or Assertions (0 terms)
      Cellular Component (0 terms)
      Terms Based on Experimental Evidence (0 terms)
      Terms Based on Predictions or Assertions (0 terms)
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Dmel\Fab-7 in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, and Transgenic Constructs
      Classical and Insertion Alleles ( 19 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 27 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of Fab-7
      Transgenic constructs containing regulatory region of Fab-7
      Deletions and Duplications ( 0 )
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Phenotype manifest in
      Allele
      Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (0)
      No records found.
      Rattus norvegicus (Norway rat) (0)
      No records found.
      Xenopus tropicalis (Western clawed frog) (0)
      No records found.
      Danio rerio (Zebrafish) (0)
      No records found.
      Caenorhabditis elegans (Nematode, roundworm) (0)
      No records found.
      Arabidopsis thaliana (thale-cress) (0)
      No records found.
      Saccharomyces cerevisiae (Brewer's yeast) (0)
      No records found.
      Schizosaccharomyces pombe (Fission yeast) (0)
      No records found.
      Orthologs in Drosophila Species (via OrthoDB v9.1) ( None identified )
      No orthologies identified
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
      No non-Drosophilid orthologies identified
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
      No non-Dipteran orthologies identified
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
      No non-Insect Arthropod orthologies identified
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
      No non-Arthropod Metazoa orthologies identified
      Paralogs
      Paralogs (via DIOPT v7.1)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement

        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map

        3-

        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        89E2-89E3
        Left limit from (method unavailable) (FBrf0091909) Right limit from (method unavailable) (FBrf0091909)
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (1)
        Genomic Clones (0)
         
          cDNA Clones (0)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments
                    Other Comments

                    Fab-7 and MCP-PRE appear to have two distinct roles; they regulate the expression of their flanking genes in cis, but they also mediate long-distance regulatory interactions with Hox genes in the Antennapedia complex.

                    Continuous transcription through the Fab-7 PRE in a transgene, producing either sense or antisense Fab-7 RNA, leads to the epigenetic activation of the Fab-7 element.

                    Trl protein-binding sites are necessary but not sufficient for full Fab-7 enhancer-blocking activity. Distinct Trl protein-binding sites within the Fab-7 element are required for different enhancer-blocking activities at different stages of development.

                    Fab-7 sites exhibit epigenetic inheritance of depressed chromatin states.

                    A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor.

                    Fab-7 can be switched to an active or a silencing mode. Both epigenetically determined states can be transmitted to a fraction of progeny in the next generation through the female germline. This suggests that a protein-based cellular memory mechanism can be propogated through meiosis.

                    The Fab-7 region can be subdivided into a chromatin domain boundary and a Polycomb-response element.

                    Chromatin domain boundary element in the Bithorax-complex. Fab-7 can be functionally subdivided into enhancer block and Pc response elements.

                    Deletion of the Fab-7 element results in fusion of the iab-6 and iab-7 cis-regulatory domains into a single regulatory domain that inappropriately regulates Abd-B. This result suggests Fab-7 is a chromatin domain boundary within the context of the bithorax complex that normally functions to ensure the autonomous activity of the iab-6 and iab-7 cis-regulatory domains.

                    A specialised DNA element, Fab-7, is proposed to function as a boundary element that separates the iab-6 and iab-7 cis regulatory regions within the Abd-B domain of the BX-C. Studies suggest Fab-7 functions as an attenuator which weakens gene expression by reducing enhancer-promoter interactions. Fab-7 selectively blocks distal enhancers in an orientation-independent fashion and can function when far from either the distal enhancer or target promoter.

                    The role of Fab-7 as a boundary element may be restricted to particular tissues in which the homeotic genes are active.

                    The Fab-7 element shows an orientation-dependent silencing of w+mC but this silencing varies between different insertion lines.

                    The sequence and chromatin organisation of Fab-7 and Mcp have been compared.

                    The 3' flanking region of Abd-B includes three silencer regulatory regions, IAB5, MCP and Fab-7, whose function is dependent on segmentation gene products.

                    The expression of the P{bluetail} insertion into the PS12-specific regulatory domain in Abd-Bblt allows dissection of the neighboring cis-regulatory region into independent domains.

                    Boundary elements in the bithorax complex, such as Fab-7 organize the parasegment specific cis-regulatory sub-regions into a series of autonomous domains, insulating each domain from the regulatory influences of the adjacent ones.

                    An insulating boundary element in the 'Fab7' region is characterized by an unusual chromatin structure.

                    Fab-7 and Mcp region chromatin structure contain distinct chromatin structures that display similarities to the scs and scs' structures of the Hsp70A locus, and are constitutive. Deletion analysis demonstrates that the DNA segment required for Fab-7 function contains 3 nuclease hypersensitive regions and that for Mcp function contains 1 major hypersensitive region and 3 minor nuclease hypersensitive regions.

                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 3 )
                    Other crossreferences
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    Synonyms and Secondary IDs (6)
                    Reported As
                    Symbol Synonym
                    Fab7 PRE
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (162)