D-cbl, dCbl, D-cblL, D-cblS, Cbl proto-oncogene ortholog
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
448 (aa); 52 (kD observed)
Cbl protein lacks proline-rich sequences at the carboxy-terminus that are found in related proteins which allow binding to SH3-domain containing adaptor proteins. An in vitro protein interaction assay was used to show that Cbl protein does not interact with drk protein. It does, however associate with activated Egfr protein in vivo.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cbl using the Feature Mapper tool.
Both Cbl protein isoforms, as assayed by Western blot analysis, are expressed at all embryonic stages, all larval instars, and in ovaries. The short isoform is predominant at all stages.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cbl in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Area matching Drosophila Cbl gene, Acc. No. U87925. This association is confirmed by overlap with Drosophila EST AA441040.
Mutations in Cbl produce dorsalised egg shells and embryos, and also cause an extra vein phenotype in the wing.
The predicted protein lacks the proline rich domain and the putative leucine zipper of c-cbl.
Named 'Cbl' after the human ortholog.