FB2025_05 , released December 11, 2025
Gene: Dmel\ATPsynγ
Open Close
General Information
Symbol
Dmel\ATPsynγ
Species
D. melanogaster
Name
ATP synthase, γ subunit
Annotation Symbol
CG7610
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020235
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. (UniProt, O01666)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ATPsyn-gamma, ATPsyn-γ, ATP synthase-gamma chain

Key Links
Genomic Location
Cytogenetic map
99B10-99B10
Sequence location
Recombination map
3-99
RefSeq locus
NT_033777 REGION:29747704..29749163
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
contributes_to proton-transporting ATP synthase activity, rotational mechanism
non-traceable author statement
(Tripoli et al., 2005)
inferred from sequence or structural similarity with UniProtKB:P38077
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000190379
(GO Reference Genome Project, 2011-)
enables proton-transporting ATP synthase activity, rotational mechanism
inferred from electronic annotation with InterPro:IPR000131, InterPro:IPR035968
(InterPro Project Members, 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proton motive force-driven ATP synthesis
inferred from electronic annotation with InterPro:IPR000131, InterPro:IPR035968
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with SGD:S000000243
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000190379
(GO Reference Genome Project, 2011-)
non-traceable author statement
(Tripoli et al., 2005)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in mitochondrial inner membrane
inferred from sequence or structural similarity with UniProtKB:P38077
(Gene Ontology Curators, 2002-)
non-traceable author statement
(Tripoli et al., 2005)
part_of proton-transporting ATP synthase complex
non-traceable author statement
(Porcelli et al., 2007, Tripoli et al., 2005)
inferred from sequence or structural similarity with UniProtKB:P38077
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR000131, InterPro:IPR035968
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the ATPase gamma chain family. (O01666)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
proton-transporting ATP synthase activity, rotational mechanism
RHEA 57722:
Summaries
Gene Group (FlyBase)
MITOCHONDRIAL COMPLEX V - CENTRAL STALK -
Mitochondrial ATP synthase (Complex V) synthesizes ATP from ADP and inorganic phosphate using the energy provided by the proton electrochemical gradient across the inner mitochondrial membrane. It consists of two structural domains: the F[[1]] sector, a soluble portion situated in the mitochondrial matrix, and the F[[0]] sector, which spans the inner mitochondrial membrane. The F[[1]] sector is composed of three copies each of subunits alpha and beta, which form the catalytic core that synthesizes ATP, and one each of subunits gamma, delta and epsilon, which constitute the central stalk. (Adapted from PMID:21874297.)
MITOCHONDRIAL COMPLEX V - TESTIS-SPECIFIC VARIANT -
Mitochondrial ATP synthase (Complex V) synthesizes ATP from ADP and inorganic phosphate using the energy provided by the proton electrochemical gradient (proton-motive force) across the inner mitochondrial membrane generated by electron transport complexes of the respiratory chain. It is an F-type ATPase and consists of two structural domains: the F1 sector, a soluble portion situated in the mitochondrial matrix, and the F0 sector, which spans the inner mitochondrial membrane. Protons pass from the inter membrane space to the matrix through F0, which transfers the energy created by the proton-motive force to F1 where ADP is phosphorylated to ATP using a rotational mechanism. (Adapted from PMID:23356252 and PMID:21874297).
MITOCHONDRIAL COMPLEX V -
Mitochondrial ATP synthase (Complex V) synthesizes ATP from ADP and inorganic phosphate using the energy provided by the proton electrochemical gradient (proton-motive force) across the inner mitochondrial membrane generated by electron transport complexes of the respiratory chain. It is an F-type ATPase and consists of two structural domains: the F1 sector, a soluble portion situated in the mitochondrial matrix, and the F0 sector, which spans the inner mitochondrial membrane. Protons pass from the inter membrane space to the matrix through F0, which transfers the energy created by the proton-motive force to F1 where ADP is phosphorylated to ATP using a rotational mechanism. (Adapted from PMID:23356252 and PMID:21874297).
Pathway (FlyBase)
OXIDATIVE PHOSPHORYLATION -
Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)
Protein Function (UniProtKB)
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
(UniProt, O01666)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ATPsynγ for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O01666)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ATPsynγ-RA
FBtr0085539
NM_079826
1080
297
ATPsynγ-RB
FBtr0085540
NM_170425
1395
297
ATPsynγ-RC
FBtr0085541
NM_170426
1166
297
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ATPsynγ-PA
FBpp0084905
32.9
297
9.67
O01666
NP_524550
AAN14185
ATPsynγ-PB
FBpp0084906
32.9
297
9.67
O01666
NP_733304
AAF56932
ATPsynγ-PC
FBpp0084907
32.9
297
9.67
O01666
NP_733305
AAN14186
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

297 aa isoforms: ATPsynγ-PA, ATPsynγ-PB, ATPsynγ-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

(UniProt, O01666)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATPsynγ using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.35

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ATPsynγ in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ATPsynγ
Transgenic constructs containing regulatory region of ATPsynγ
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel9025
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\ATP5F1C
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Atp5f1c
12 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Atp5c1
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\atp5f1c
11 of 13
Yes
Yes
Xtro\ehmt1
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\atp5f1c
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y69A2AR.18
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP007966
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\ATP3
13 of 13
Yes
Yes
Atha\ATPC1
5 of 13
No
Yes
Atha\ATPC2
5 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ATP3
13 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\atp3
12 of 12
Yes
Yes
Escherichia coli (enterobacterium) (1)
Ecol\atpG
8 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ATPsynγ. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATP5F1C; ATP synthase F1 subunit gamma
    14 of 14
    108729
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        ATPsynγ - ATPsynB
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ATPsynCF6
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ATPsynD
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ATPsynF
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ATPsynO
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ATPsynδ
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Akt
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        ATPsynγ - CCT3
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - CCT6
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - CG1416
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - CG2065
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Chc
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Cyp12d1-p
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Gp93
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Ldh
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Mcad
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Mec2
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Ost1
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Ost48
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Rab1
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Rab2
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Rab5
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Rdh1
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Rpt1
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Rpt4
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - SERCA
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ScsβA
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ScsβG
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - SsRβ
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Tapδ
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - Tecr
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - UQCR-C2
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - blw
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - mEFTu1
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - mt:CoII
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - ox
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - porin
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - spidey
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - sun
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynγ - wal
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
        (UniProt, O01666 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        OXIDATIVE PHOSPHORYLATION
        External Links
        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-99
        Cytogenetic map
        99B10-99B10
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        99B10-99B10
        Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        99B-99B
        (Caggese, 1997.4.21)
        99B6-99B10
        (determined by in situ hybridisation)
        (Caggese et al., 1999)
        Experimentally Determined Recombination Data
        Location

        3-99

        (FlyBase, 2016)

        3-96.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (12)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (239)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

            (Stroschein-Stevenson et al., 2006)

            RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

            (Boutros et al., 2004)
            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: ATPsynγ ATPsyn-γ

            (Porcelli and Marygold, 2014.9.16)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (19)
            Reported As
            Symbol Synonym
            ATP-syn-γ
            (Li et al., 2016)
            ATPG
            (Caggese et al., 2006)
            ATPG_DROME
            (Storm and Sonnhammer, 2003)
            ATPsyn-gam
            (Dorus et al., 2006)
            ATPsyn-gamma
            (Lotz et al., 2014, Kwon et al., 2013, Short and Lazzaro, 2013, Gurudatta et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Wasbrough et al., 2010, Tan et al., 2009, Porcelli et al., 2007, Beller et al., 2006, Caggese et al., 2006, Tripoli et al., 2005, Giot et al., 2003)
            ATPsyn-γ
            (Curcio et al., 2024, Collins et al., 2018, Stuart et al., 2007, Stroschein-Stevenson et al., 2006)
            ATPsynγ
            (Salminen et al., 2024, Ren et al., 2023, Ding et al., 2022, van den Ameele and Brand, 2019, Porcelli and Marygold, 2014.9.16)
            CG7610
            (Curcio et al., 2024, Kolkhof et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Teixeira et al., 2015, Fukuoh et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Porcelli et al., 2007, Cermelli et al., 2006)
            Name Synonyms
            ATP synthase Gamma chain
            (Tripoli et al., 2005)
            ATP synthase gamma chain
            (Caggese et al., 2006)
            ATP synthase subunit gamma
            (Caggese, 1997.4.21)
            ATP synthase, γ subunit
            (Porcelli and Marygold, 2014.9.16)
            ATP synthase-gamma chain
            (Sen and Cox, 2016, Jaspers et al., 2012, Cammarato et al., 2011)
            ATP synthase-γ chain
            ATPsyn-gamma chain
            (Cermelli et al., 2006)
            ATPsynthase gamma
            (Mossman et al., 2019)
            F0/F1 ATP synthase Gamma
            (Porcelli et al., 2007)
            F1ATP synthase
            (Gandhi et al., 2004)
            catalytic core of F1 ATP synthase of complex V
            (Chang et al., 2011)
            Secondary FlyBase IDs
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 48 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
              References (81)