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Gene Dmel\ATPCL

General Information
Symbol	Dmel\ATPCL	Species	D. melanogaster
Name	ATP citrate lyase	Annotation symbol	CG8322
Feature type	protein_coding_gene	FlyBase ID	FBgn0020236
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52D10-52D12	Sequence location	2R:11,881,036..11,888,795 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ATP citrate lyase is referred to in FlyBase by the symbol Dmel\ATPCL (CG8322, FBgn0020236). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP citrate synthase activity. Based on sequence similarity, it is predicted to be involved in the biological process: citrate metabolic process; acetyl-CoA biosynthetic process. 14 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: ATP-citrate lyase/succinyl-CoA ligase; ATP-citrate lyase/succinyl-CoA ligase, active site; ATP-citrate synthase; ATP-grasp fold, subdomain 2; ATP-grasp fold, succinyl-CoA synthetase-type; Citrate synthase-like; Citrate synthase-like, core; Citrate synthase-like, large alpha subdomain; Citrate synthase-like, small alpha subdomain; CoA-binding; NAD(P)-binding domain; Succinyl-CoA ligase, alpha subunit; Succinyl-CoA synthetase, beta subunit, conserved site; Succinyl-CoA synthetase-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1634006_s_at completely aligns to an exonic region of only a subset of 1 of the 3 FlyBase-annotated transcript isoforms of ATPCL. Gene sequence location is 2R:11879931..11888795.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52D10-52D12   Limits computationally determined from genome sequence between P{lacW}l(2)k02205k02205&P{PZ}sli05248 and P{lacW}ATPCLk09217
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52D9-52D10   (determined by in situ hybridisation) 52D11--12 (determined by in situ hybridisation)   (Spradling et al., 1999) 52D9-52D10   52D11--12   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ATPCL for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ATPCL-RD FBtr0300596  NM_079031   3874   1112 ATPCL-RE FBtr0300597  NM_001144202   4146   1112 ATPCL-RF FBtr0300598  NM_166131   3913   1095 ATPCL-RG FBtr0340016     3916   1096
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ATPCL-PD   FBpp0289823   121.4   1112   7.33     NP_523755   AAF58082 ATPCL-PE   FBpp0289824   121.4   1112   7.33     NP_001137674   ACL83128 ATPCL-PF   FBpp0289825   119.7   1095   7.13     NP_725514   AAM70940 ATPCL-PG   FBpp0309030   119.8   1096   7.13
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CoA-binding (IPR003781) Succinyl-CoA ligase, alpha subunit (IPR005810) ATP-citrate lyase/succinyl-CoA ligase (IPR005811) ATP-grasp fold, succinyl-CoA synthetase-type (IPR013650) ATP-grasp fold, subdomain 2 (IPR013816) ATP-citrate synthase (IPR014608) Succinyl-CoA synthetase-like (IPR016102) Citrate synthase-like, core (IPR016141) Citrate synthase-like, small alpha subdomain (IPR016143) ATP-citrate lyase/succinyl-CoA ligase, active site (IPR017440) NAD(P)-binding domain (IPR016040) Succinyl-CoA synthetase, beta subunit, conserved site (IPR017866) Citrate synthase-like (IPR002020) Citrate synthase-like, large alpha subdomain (IPR016142)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695049   AA697678   AA735448   AE013599 AAF58082   AE013599 AAM70940   AC004426   AC004516   AE013599 ACL83128   AF132166 AAD34754   AI403661   AI405870   AI455129   AI541859   AQ025890   AQ034162   AQ073497   AX154830   BF502123   BI162207   BI162208   BI565292   BI576638   BI583256   BI604329   BI605742   BI609969   BI610618   BI613502   BI618965   BI621310   BI633319   BP552353   BT010203 AAQ23521   BT015200   CK657000   CK660003   CO177048   CO187135   CO188767   CO268664   CO270419   CO276762   CO276788   CO281720   CO282943   CO282989   CO287154   CO291817   CO291884   CO295518   CO302072   CO310027   CO316474   CO316927   CO320933   CO326024   CO329985   CO341223   CZ468218   CZ479244   CZ479245   CZ482011   EC057517   EC062698   EC063545   EC064445   EC067419   EC069266   EC069693   EC073769   EC074617   EC075835   EC078001   EC082250   EC082320   EC089386   EC199798   EC201481   EC201787   EC210990   EC215359   EC217839   EC224023   EC230143   EC232170   EC236500   EC242789   EC242851   EC243540   EC245878   EC250627   EC252154   EV577414   EV577416   EV578085   EV581564   EV581688   EV587157   U87317 AAB47486
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KN85 E2QCF1 Q7JNC6 Q6NR74
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.575 Larval Midgut    1.1 Larval Hindgut    2.8 Larval Malpighian Tubules    5.5 Larval Fat Body    6.9 Larval Salivary Gland    8.6 Larval Trachea    3.225 Larval Carcass    2.275 Adult Head    4.8 Adult Eye    5.075 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    5.5 Adult Midgut    4.6 Adult Hindgut    5.1 Adult Malpighian Tubules    3 Adult Fat Body    7.3 Adult Salivary Gland    8.1 Adult Heart    3.95 Adult VirginFemale Spermatheca    16.9 Adult InseminatedFemale Spermatheca    20.1 Adult Ovary    4 Adult Testis    1 Adult Male Accessory Gland    3.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.8   NA  Eye    5.075   NA  Brain    1.7   4.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.6   NA  Crop    5.5   1.1  Midgut    4.6   2.8  Hindgut    5.1   5.5  Malpighian Tubules    3   6.9  Fat Body    7.3   8.6  Salivary Gland    8.1   NA  Heart    3.95   3.225  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    4   NA  Testis    1   NA  Male Accessory Gland    3.4   2.275  Carcass    4.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    63 head, virgin 4-day female    60 head, virgin 20-day female    119 head, mated 1-day female    50 head, mated 4-day female    65 head, mated 20-day female    79 head, mated 1-day male    60 head, mated 4-day male    112 head, mated 20-day male    209 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    43 digestive system, 4-day adult    44 digestive system, 20-day adult    55 fat body, larvae L3 wandering    70 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    190 carcass, 1-day adult    87 carcass, 4-day adult    105 carcass, 20-day adult    142 ovary, virgin 4-day female    72 ovary, mated 4-day female    58 testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (44) central nervous system, pupae P8  (32) head, virgin 1-day female  (63) head, virgin 4-day female  (60) head, virgin 20-day female  (119) head, mated 1-day female  (50) head, mated 4-day female  (65) head, mated 20-day female  (79) head, mated 1-day male  (60) head, mated 4-day male  (112) head, mated 20-day male  (209) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult  (43) digestive system, 4-day adult  (44) digestive system, 20-day adult  (55) fat body, larvae L3 wandering  (70) fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering  (190) carcass, 1-day adult  (87) carcass, 4-day adult  (105) carcass, 20-day adult  (142) ovary, virgin 4-day female  (72) ovary, mated 4-day female  (58) testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    63 head, virgin 4-day female    60 head, virgin 20-day female  (119) head, mated 1-day female    50 head, mated 4-day female    65 head, mated 20-day female    79 head, mated 1-day male    60 head, mated 4-day male  (112) head, mated 20-day male  (209) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    43 digestive system, 4-day adult    44 digestive system, 20-day adult    55 fat body, larvae L3 wandering    70 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering  (190) carcass, 1-day adult    87 carcass, 4-day adult  105 carcass, 20-day adult  (142) ovary, virgin 4-day female    72 ovary, mated 4-day female    58 testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    63 head, virgin 4-day female    60 head, virgin 20-day female    119 head, mated 1-day female    50 head, mated 4-day female    65 head, mated 20-day female    79 head, mated 1-day male    60 head, mated 4-day male    112 head, mated 20-day male    209 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    43 digestive system, 4-day adult    44 digestive system, 20-day adult    55 fat body, larvae L3 wandering    70 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    190 carcass, 1-day adult    87 carcass, 4-day adult    105 carcass, 20-day adult    142 ovary, virgin 4-day female    72 ovary, mated 4-day female    58 testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    63 head, virgin 4-day female    60 head, virgin 20-day female    119 head, mated 1-day female    50 head, mated 4-day female    65 head, mated 20-day female    79 head, mated 1-day male    60 head, mated 4-day male    112 head, mated 20-day male    209 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    43 digestive system, 4-day adult    44 digestive system, 20-day adult    55 fat body, larvae L3 wandering    70 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    190 carcass, 1-day adult    87 carcass, 4-day adult    105 carcass, 20-day adult    142 ovary, virgin 4-day female    72 ovary, mated 4-day female    58 testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (44) central nervous system, pupae P8  32 head, virgin 1-day female  (63) head, virgin 4-day female  (60) head, virgin 20-day female  (119) head, mated 1-day female  (50) head, mated 4-day female  (65) head, mated 20-day female  (79) head, mated 1-day male  (60) head, mated 4-day male  (112) head, mated 20-day male  (209) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult  (43) digestive system, 4-day adult  (44) digestive system, 20-day adult  (55) fat body, larvae L3 wandering  (70) fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering  (190) carcass, 1-day adult  (87) carcass, 4-day adult  (105) carcass, 20-day adult  (142) ovary, virgin 4-day female  (72) ovary, mated 4-day female  (58) testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    63 head, virgin 4-day female    60 head, virgin 20-day female  119 head, mated 1-day female    50 head, mated 4-day female    65 head, mated 20-day female    79 head, mated 1-day male    60 head, mated 4-day male  112 head, mated 20-day male  (209) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    43 digestive system, 4-day adult    44 digestive system, 20-day adult    55 fat body, larvae L3 wandering    70 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering  (190) carcass, 1-day adult    87 carcass, 4-day adult  105 carcass, 20-day adult  142 ovary, virgin 4-day female    72 ovary, mated 4-day female    58 testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    63 head, virgin 4-day female    60 head, virgin 20-day female    119 head, mated 1-day female    50 head, mated 4-day female    65 head, mated 20-day female    79 head, mated 1-day male    60 head, mated 4-day male    112 head, mated 20-day male    209 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    43 digestive system, 4-day adult    44 digestive system, 20-day adult    55 fat body, larvae L3 wandering    70 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    190 carcass, 1-day adult    87 carcass, 4-day adult    105 carcass, 20-day adult    142 ovary, virgin 4-day female    72 ovary, mated 4-day female    58 testis, mated 4-day male    19 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    36 embryo 04-06hr    79 embryo 06-08hr    72 embryo 08-10hr    54 embryo 10-12hr    68 embryo 12-14hr    98 embryo 14-16hr    164 embryo 16-18hr    55 embryo 18-20hr    37 embryo 20-22hr    60 embryo 22-24hr    68 larva L1    91 larva L2    158 larva L3 12hr old    156 larva L3 puffstage 1-2    78 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    123 white prepupae new    81 white prepupae 12hr    73 white prepupae 24hr    49 pupae 2d postWPP    75 pupae 3d postWPP    46 pupae 4d postWPP    74 adult male 01day    133 adult male 05day    131 adult male 30day    98 adult female 01day    108 adult female 05day    119 adult female 30day    122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (99) embryo 02-04hr  (36) embryo 04-06hr  (79) embryo 06-08hr  (72) embryo 08-10hr  (54) embryo 10-12hr  (68) embryo 12-14hr  (98) embryo 14-16hr  (164) embryo 16-18hr  (55) embryo 18-20hr  (37) embryo 20-22hr  (60) embryo 22-24hr  (68) larva L1  (91) larva L2  (158) larva L3 12hr old  (156) larva L3 puffstage 1-2  (78) larva L3 puffstage 3-6  (78) larva L3 puffstage 7-9  (123) white prepupae new  (81) white prepupae 12hr  (73) white prepupae 24hr  (49) pupae 2d postWPP  (75) pupae 3d postWPP  (46) pupae 4d postWPP  (74) adult male 01day  (133) adult male 05day  (131) adult male 30day  (98) adult female 01day  (108) adult female 05day  (119) adult female 30day  (122) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    36 embryo 04-06hr    79 embryo 06-08hr    72 embryo 08-10hr    54 embryo 10-12hr    68 embryo 12-14hr    98 embryo 14-16hr  (164) embryo 16-18hr    55 embryo 18-20hr    37 embryo 20-22hr    60 embryo 22-24hr    68 larva L1    91 larva L2  (158) larva L3 12hr old  (156) larva L3 puffstage 1-2    78 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9  (123) white prepupae new    81 white prepupae 12hr    73 white prepupae 24hr    49 pupae 2d postWPP    75 pupae 3d postWPP    46 pupae 4d postWPP    74 adult male 01day  (133) adult male 05day  (131) adult male 30day    98 adult female 01day  (108) adult female 05day  (119) adult female 30day  (122) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    36 embryo 04-06hr    79 embryo 06-08hr    72 embryo 08-10hr    54 embryo 10-12hr    68 embryo 12-14hr    98 embryo 14-16hr    164 embryo 16-18hr    55 embryo 18-20hr    37 embryo 20-22hr    60 embryo 22-24hr    68 larva L1    91 larva L2    158 larva L3 12hr old    156 larva L3 puffstage 1-2    78 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    123 white prepupae new    81 white prepupae 12hr    73 white prepupae 24hr    49 pupae 2d postWPP    75 pupae 3d postWPP    46 pupae 4d postWPP    74 adult male 01day    133 adult male 05day    131 adult male 30day    98 adult female 01day    108 adult female 05day    119 adult female 30day    122 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    36 embryo 04-06hr    79 embryo 06-08hr    72 embryo 08-10hr    54 embryo 10-12hr    68 embryo 12-14hr    98 embryo 14-16hr    164 embryo 16-18hr    55 embryo 18-20hr    37 embryo 20-22hr    60 embryo 22-24hr    68 larva L1    91 larva L2    158 larva L3 12hr old    156 larva L3 puffstage 1-2    78 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    123 white prepupae new    81 white prepupae 12hr    73 white prepupae 24hr    49 pupae 2d postWPP    75 pupae 3d postWPP    46 pupae 4d postWPP    74 adult male 01day    133 adult male 05day    131 adult male 30day    98 adult female 01day    108 adult female 05day    119 adult female 30day    122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (99) embryo 02-04hr  (36) embryo 04-06hr  (79) embryo 06-08hr  (72) embryo 08-10hr  (54) embryo 10-12hr  (68) embryo 12-14hr  (98) embryo 14-16hr  (164) embryo 16-18hr  (55) embryo 18-20hr  (37) embryo 20-22hr  (60) embryo 22-24hr  (68) larva L1  (91) larva L2  (158) larva L3 12hr old  (156) larva L3 puffstage 1-2  (78) larva L3 puffstage 3-6  (78) larva L3 puffstage 7-9  (123) white prepupae new  (81) white prepupae 12hr  (73) white prepupae 24hr  (49) pupae 2d postWPP  (75) pupae 3d postWPP  (46) pupae 4d postWPP  (74) adult male 01day  (133) adult male 05day  (131) adult male 30day  (98) adult female 01day  (108) adult female 05day  (119) adult female 30day  (122) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    36 embryo 04-06hr    79 embryo 06-08hr    72 embryo 08-10hr    54 embryo 10-12hr    68 embryo 12-14hr    98 embryo 14-16hr  (164) embryo 16-18hr    55 embryo 18-20hr    37 embryo 20-22hr    60 embryo 22-24hr    68 larva L1    91 larva L2  (158) larva L3 12hr old  (156) larva L3 puffstage 1-2    78 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9  123 white prepupae new    81 white prepupae 12hr    73 white prepupae 24hr    49 pupae 2d postWPP    75 pupae 3d postWPP    46 pupae 4d postWPP    74 adult male 01day  133 adult male 05day  131 adult male 30day    98 adult female 01day  108 adult female 05day  119 adult female 30day  122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    36 embryo 04-06hr    79 embryo 06-08hr    72 embryo 08-10hr    54 embryo 10-12hr    68 embryo 12-14hr    98 embryo 14-16hr    164 embryo 16-18hr    55 embryo 18-20hr    37 embryo 20-22hr    60 embryo 22-24hr    68 larva L1    91 larva L2    158 larva L3 12hr old    156 larva L3 puffstage 1-2    78 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    123 white prepupae new    81 white prepupae 12hr    73 white prepupae 24hr    49 pupae 2d postWPP    75 pupae 3d postWPP    46 pupae 4d postWPP    74 adult male 01day    133 adult male 05day    131 adult male 30day    98 adult female 01day    108 adult female 05day    119 adult female 30day    122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    89 embryonic 1182-4H    55 embryonic GM2    87 embryonic Kc167    44 embryonic S1    64 embryonic S3    152 leg disc CME L1    63 wing disc CME-W2    62 wing disc ML-DmD8    54 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    47 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    47 CNS ML-DmBG2-c2    270 tumorous blood cells mbn2    58 ovary fGS/OSS    35 ovary OSC    55 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (89) embryonic 1182-4H  (55) embryonic GM2  (87) embryonic Kc167  (44) embryonic S1  (64) embryonic S3  (152) leg disc CME L1  (63) wing disc CME-W2  (62) wing disc ML-DmD8  (54) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21  (47) wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3  (113) eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (47) CNS ML-DmBG2-c2  (270) tumorous blood cells mbn2  (58) ovary fGS/OSS  (35) ovary OSC  (55) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4    89 embryonic 1182-4H    55 embryonic GM2    87 embryonic Kc167    44 embryonic S1    64 embryonic S3  (152) leg disc CME L1    63 wing disc CME-W2    62 wing disc ML-DmD8    54 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    47 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3  (113) eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    47 CNS ML-DmBG2-c2  (270) tumorous blood cells mbn2    58 ovary fGS/OSS    35 ovary OSC    55 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    89 embryonic 1182-4H    55 embryonic GM2    87 embryonic Kc167    44 embryonic S1    64 embryonic S3    152 leg disc CME L1    63 wing disc CME-W2    62 wing disc ML-DmD8    54 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    47 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    47 CNS ML-DmBG2-c2    270 tumorous blood cells mbn2    58 ovary fGS/OSS    35 ovary OSC    55 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    89 embryonic 1182-4H    55 embryonic GM2    87 embryonic Kc167    44 embryonic S1    64 embryonic S3    152 leg disc CME L1    63 wing disc CME-W2    62 wing disc ML-DmD8    54 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    47 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    47 CNS ML-DmBG2-c2    270 tumorous blood cells mbn2    58 ovary fGS/OSS    35 ovary OSC    55 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (89) embryonic 1182-4H  (55) embryonic GM2  (87) embryonic Kc167  (44) embryonic S1  (64) embryonic S3  (152) leg disc CME L1  (63) wing disc CME-W2  (62) wing disc ML-DmD8  (54) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21  (47) wing disc ML-DmD32  29 haltere disc ML-DmD17-c3  (113) eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (47) CNS ML-DmBG2-c2  (270) tumorous blood cells mbn2  (58) ovary fGS/OSS  (35) ovary OSC  (55) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  126 Schneider line 2 Sg4    89 embryonic 1182-4H    55 embryonic GM2    87 embryonic Kc167    44 embryonic S1    64 embryonic S3  (152) leg disc CME L1    63 wing disc CME-W2    62 wing disc ML-DmD8    54 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    47 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3  113 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    47 CNS ML-DmBG2-c2  (270) tumorous blood cells mbn2    58 ovary fGS/OSS    35 ovary OSC    55 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    89 embryonic 1182-4H    55 embryonic GM2    87 embryonic Kc167    44 embryonic S1    64 embryonic S3    152 leg disc CME L1    63 wing disc CME-W2    62 wing disc ML-DmD8    54 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    47 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    47 CNS ML-DmBG2-c2    270 tumorous blood cells mbn2    58 ovary fGS/OSS    35 ovary OSC    55 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    77 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    63 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    75 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    23 heat shock, 4-day adult  (70) Cadmium 50 mM 6 hrs, larvae L3  (77) Cadmium 50 mM 12 hrs, larvae L3  (64) Cadmium 50 mM 48 hrs, 4-day adult  (95) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (33) Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3  (27) Zinc 4.5 mM 48 hrs, 4-day adult  (29) Ethanol 2.5% 3 hrs, larvae L3  (75) Ethanol 5% 3 hrs, larvae L3  (111) Ethanol 10% 3 hrs, larvae L3  (110) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (56) Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult  (63) Paraquat 10 mM 48 hrs, 4-day adult  (93) Rotenone 2 μg 12 hrs, larvae L3  (75) Rotenone 8 μg 12 hrs, larvae L3  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    77 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3  (111) Ethanol 10% 3 hrs, larvae L3  (110) Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    63 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    75 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    77 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    63 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    75 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    77 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    63 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    75 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    23 heat shock, 4-day adult  (70) Cadmium 50 mM 6 hrs, larvae L3  (77) Cadmium 50 mM 12 hrs, larvae L3  (64) Cadmium 50 mM 48 hrs, 4-day adult  (95) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (33) Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3  27 Zinc 4.5 mM 48 hrs, 4-day adult  29 Ethanol 2.5% 3 hrs, larvae L3  (75) Ethanol 5% 3 hrs, larvae L3  (111) Ethanol 10% 3 hrs, larvae L3  (110) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (56) Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult  (63) Paraquat 10 mM 48 hrs, 4-day adult  (93) Rotenone 2 μg 12 hrs, larvae L3  (75) Rotenone 8 μg 12 hrs, larvae L3  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    77 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3  111 Ethanol 10% 3 hrs, larvae L3  110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    63 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    75 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    77 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    63 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    75 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020236 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8322-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive ATPCL01466 partially lethal - majority die ATPCL01466 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 ATPCLGD3552 viable ATPCLk09217 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 ATPCLGD3552 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 ATPCLGD3552 trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 ATPCLGD3552
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of ATPCL Class Mutagen Stocks Known lesion ATPCLk09217 P-element activity 2 -- ATPCL01466 P-element activity 1 Yes ATPCLc02804 piggyBac transposase 1 -- ATPCLCB-0549-3 1 -- ATPCLCB-0831-3 1 -- ATPCLDG20812 1 -- ATPCLDG23402 P-element activity 1 -- ATPCLe01432 piggyBac transposase 1 -- ATPCLMB01163 1 -- ATPCLNP0624 1 -- ATPCLe04264 piggyBac transposase 0 -- ATPCLEP2329 P-element activity 0 -- ATPCLSH1787 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ATPCL Class Mutagen Stocks Known lesion ATPCLGD3552 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7138 (Ryder, 2004.4.26) Df(2R)Jp1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Jp4 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)Jp6 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3552} NA P{GD17534} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}CG42671BG00805 NA P{PTT-GB}CG8370CB04427 NA P{RS3}ATPCLCB-0549-3 NA P{RS3}ATPCLCB-0831-3 NA P{SUPor-P}KG00786 NA P{wHy}ATPCLDG23402 NA P{wHy}CG8320DG20812 NA PBac{PB}ATPCLc02804 NA PBac{RB}ATPCLe01432 NA PBac{RB}ATPCLe04264 NA insertion of enhancer trap P{lacW}ATPCLk09217 No P{lacW}ATPCLSH1787 No P{lacW}l(2)SH0527SH0527 No P{PZ}ATPCL01466 No insertion of enhancer trap binary system Mi{ET1}CG8320MB01163 No P{GawB}ATPCLNP0624 No insertion of mobile activating element P{EP}ATPCLEP2329 NA P{GSV1}EP-M21 NA P{GSV1}GSd415GSd415 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR013816 (FlyBase Curators et al., 2004-) ATP citrate synthase activity inferred from sequence or structural similarity (Spradling et al., 1999) inferred from sequence or structural similarity with UniProtKB:P16638 (FlyBase, 1992-) non-traceable author statement (Ryerse, 1997.1.27) cofactor binding inferred from electronic annotation with InterPro:IPR003781 (FlyBase Curators et al., 2004-) succinate-CoA ligase (ADP-forming) activity inferred from electronic annotation with InterPro:IPR017440 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
acetyl-CoA biosynthetic process inferred from sequence or structural similarity with UniProtKB:P16638 (FlyBase, 1992-) cellular carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR002020, InterPro:IPR014608, InterPro:IPR016141, InterPro:IPR016142, InterPro:IPR016143 (FlyBase Curators et al., 2004-) citrate metabolic process inferred from sequence or structural similarity with UniProtKB:P16638 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with UniProtKB:P16638 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ATPCL - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPCL - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPCL - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPCL - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ATPCL allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62486 DroID - A comprehensive database of gene and protein interactions. • FBgn0020236 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36760
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG698VK3 Dipteran inclusive ortholog search EOG6XH072 Insect inclusive ortholog search EOG6XKT2V Arthropod inclusive ortholog search EOG6STQKG Metazoa inclusive ortholog search EOG6WQCV9
Orthologs in Drosophila Species (EOG698VK3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ATPCL     Drosophila simulans   Dsim\GD25577 Y   Drosophila sechellia   Dsec\GM20101 Y   Drosophila erecta   Dere\GG22311 Y   Drosophila yakuba   Dyak\GE14108 Y   Drosophila ananassae   Dana\GF13329 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20986 Y   Drosophila persimilis   Dper\GL20648 Y   Drosophila willistoni   Dwil\GK10643 Y   Drosophila virilis   Dvir\GJ20089 Y   Drosophila mojavensis   Dmoj\GI20417 Y   Drosophila grimshawi   Dgri\GH19829 Y
Orthologs in non-Drosophila Dipterans (EOG6XH072)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004297   Anopheles gambiae Malaria mosquito  Agam\AGAP010156   Anopheles gambiae Malaria mosquito  Agam\AGAP010155   Anopheles gambiae Malaria mosquito  Agam\AGAP010154   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000859
Orthologs in non-Dipteran Insects (EOG6XKT2V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\ATPCL   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007739   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19392   Atta cephalotes Leafcutter ant  Acep\ACEP27981   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21877   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21876   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18429   Linepithema humile Argentine ant  Lhum\LH21038   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22151   Solenopsis invicta Red fire ant  Sinv\SINV19987   Solenopsis invicta Red fire ant  Sinv\SINV19989   Acyrthosiphon pisum Pea aphid  Apim\ACYPI067814   Bombyx mori Silkmoth  Bmor\BGIBMGA014294   Bombyx mori Silkmoth  Bmor\BGIBMGA014446   Pediculus humanus Human body louse  Phum\PHUM337470   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15096
Orthologs in non-Insect Arthropods (EOG6STQKG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Tmc4   Ixodes scapularis Deer tick  Isca\ISCW009919   Ixodes scapularis Deer tick  Isca\ISCW024816
Orthologs in non-Arthropod Metazoa (EOG6WQCV9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\D1005.1   Caenorhabditis elegans Nematode  Cele\B0365.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000947gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006509gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004450gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011751gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025934gn   Danio rerio Zebrafish  Drer\aclya   Danio rerio Zebrafish  Drer\ENSDARG00000055652   Xenopus tropicalis Western clawed frog  Xtro\acly   Gallus gallus Domestic chicken  Ggal\ACLY   Mus musculus House mouse  Mmus\Acly   Rattus norvegicus Norway rat  Rnor\Acly   Homo sapiens Human  Hsap\ACLY
Human Orthologs (1)
Gene OMIM HGNC Hsap\ACLY
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25577 Drosophila sechellia Dsec\GM20101 Drosophila erecta Dere\GG22311 Drosophila yakuba Dyak\GE14108 Drosophila ananassae Dana\GF13329 Drosophila pseudoobscura pseudoobscura Dpse\GA20986 Drosophila persimilis Dper\GL20648 Drosophila willistoni Dwil\GK10643 Drosophila virilis Dvir\GJ20089 Drosophila mojavensis Dmoj\GI20417 Drosophila grimshawi Dgri\GH19829
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	11055 cn1 P{PZ}ATPCL01466/CyO; ry506 21750 y1 w67c23; P{wHy}CG8320DG20812 ATPCLDG20812 23005 y1 w67c23; Mi{ET1}CG8320MB01163 ATPCLMB01163 10865 y1 w67c23; P{lacW}ATPCLk09217, l(2)k09217k09217/CyO
Harvard	- PBac{PB}ATPCLc02804 - PBac{RB}ATPCLe01432
Kyoto	123234 w1118; P{RS3}ATPCLCB-0549-3 123342 w1118; P{RS3}ATPCLCB-0831-3 103681 w*; P{GawB}ATPCLNP0624 / CyO 102696 y1 w67c23 ; P{lacW}ATPCLk09217 / CyO
VDRC	v30280 w1118; P{GD3552}v30280 v30282 w1118; P{GD3552}v30282/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR04O19 BACR07M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 76 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21334 RE70805
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17757 GH23146 GH26022 GM02007 HL02970 LP18207 LP22907 RH14829 RH16145 RH21806 RH33239 RH42664 RH49918 RH52633 RH63035 RH69648 RH71641 SD27380
Other clones	453 487 45826 51241 54871 57311 63780 70716 70761 76983 81530 82702 83048 97453 161044 161762 161876 184158 191691 214345.70 CK01.30B.D3 CK01.30B.H7 CK01.50D.F9 CK01.64B.E6 CK01.108A.E12 CK01.109B.G7 Dmel_dig_001169_0663_3736 Dmel_dig_005399_0633_3414 Dmel_dig_015767_0654_3073 Dmel_dig_016086_0681_3548 Dmel_dig_017201_0685_1811 Dmel_neb_011790_0095_1178 EK026614 EK041821 EK052239 EK065051 EK092250 EK098828 EK122013 EK122049 EK158636 EK161824 EK161944 EK183010 EK198421 EK198610 EK210445 EK220262 EK265039 EK266310 EK288834 EK294311 EP03102 EP12054 FGM218C07 RE01584
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020236 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36760
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ATPCL anon-WO0140519.179 (FlyBase, 1996-) Source for merge of: ATPCL l(2)01466 (Misra, 2000.8.25)
Additional comments	Source for merge of ATPCL anon-WO0140519.179 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; increased expression in per01, tim01 and ClkJrk background. (Claridge-Chang et al., 2001) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. (McDonald and Rosbash, 2001) Isolated from a 2-14 hour embryonic cDNA library. (Ryerse et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079031 NM_166131 NM_001144202 RefSeq (Proteins) • NP_523755 NP_725514 NP_001137674 DDBJ / EMBL / GenBank • AA735448 AAB47486 AAD34754 AAF58082 AAM70940 AAQ23521 AC004426 AC004516 ACL83128 AF132166 AI455129 AI541859 AQ025890 AQ034162 AQ073497 AX154830 BT010203 CZ468218 CZ479244 CZ479245 CZ482011 U87317 Entrez Gene - A searchable database of RefSeq genes. • 36760 UniProtKB/TrEMBL • E2QCF1 Q6NR74 Q7JNC6 Q7KN85
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CoA-binding (IPR003781) Succinyl-CoA ligase, alpha subunit (IPR005810) ATP-citrate lyase/succinyl-CoA ligase (IPR005811) ATP-grasp fold, succinyl-CoA synthetase-type (IPR013650) ATP-grasp fold, subdomain 2 (IPR013816) ATP-citrate synthase (IPR014608) Succinyl-CoA synthetase-like (IPR016102) Citrate synthase-like, core (IPR016141) Citrate synthase-like, small alpha subdomain (IPR016143) ATP-citrate lyase/succinyl-CoA ligase, active site (IPR017440) NAD(P)-binding domain (IPR016040) Succinyl-CoA synthetase, beta subunit, conserved site (IPR017866) Citrate synthase-like (IPR002020) Citrate synthase-like, large alpha subdomain (IPR016142)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62486 DroID - A comprehensive database of gene and protein interactions. • FBgn0020236 DRSC - Results from RNAi screens. • FBgn0020236 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020236 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8322-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020236 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36760 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36760 modMine - Data generated by the modENCODE project. • FBgn0020236
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-WO0140519.179   ATPCL (Beller et al., 2006, Dionne et al., 2006, Buszczak et al., 2007, Lim et al., 2011, Molnar et al., 2006, FlyBase Curators, 2008) BcDNA:LD21334 (Giot et al., 2003, ) CG8322 (Seegmiller et al., 2002, Beller et al., 2006, Molnar et al., 2006, Roxstrom-Lindquist et al., 2004, Cammarato et al., 2011) dATPCL (Sassu et al., 2012) DmATPCL (Ryerse et al., 1997) l(2)01466 (Spradling et al., 1999, ) l(2)k09217 (Beaton, 2000.1.31) n(2)k09217 (Spradling, 1999.12.9)
Name Synonym	ATP citrate lyase (Ryerse, 1997.1.27, Ryerse et al., 1997, Cammarato et al., 2011) ATP-citrate lyase (Chang et al., 2011)
Secondary FlyBase IDs
	FBgn0010490 FBgn0044698
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 10 ) Review  ( 2 ) Personal communication to FlyBase  ( 15 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 4 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Sassu et al., 2012, Biochem. Biophys. Res. Commun. 426(1): 43--48 Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. [FBrf0219467] Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Lim et al., 2011, Genes Dev. 25(2): 189--200 Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. [FBrf0212844] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...