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Gene Dmel\Mcr

General Information
Symbol	Dmel\Mcr	Species	D. melanogaster
Name	Macroglobulin complement-related	Annotation symbol	CG7586
Feature type	protein_coding_gene	FlyBase ID	FBgn0020240
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	28E1-28E3	Sequence location	2L:8,074,109..8,082,969 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Macroglobulin complement-related is referred to in FlyBase by the symbol Dmel\Mcr (CG7586, FBgn0020240). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; eukaryotic cell surface binding. There is experimental evidence that it is involved in the biological process: response to yeast; lateral inhibition; phagocytosis, engulfment. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; chaeta. It has one annotated transcript and one annotated polypeptide. Protein features are: A-macroglobulin complement component; Alpha-2-macroglobulin; Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; Alpha-macroglobulin, receptor-binding; Low-density lipoprotein (LDL) receptor class A repeat; Terpenoid cylases/protein prenyltransferase alpha-alpha toroid. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629779_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Mcr. Gene sequence location is 2L:8074109..8082969.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Guenin et al., 2010, BMC Genomics 11: 47 Sequence features BKN25702 HFA03366
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28E1-28E3   Limits computationally determined from genome sequence between P{EP}poeEP737 and P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28D-28E     (Crowley, 1997.2.6) 28D-28E     (Crowley et al., 1993)
Experimentally Determined Recombination Data
Location	2- (Crowley, 1997.2.6)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mcr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mcr-RA FBtr0079543  NM_079949   6291   1760
Additional Transcript Data & Comments
Reported size (kB)	8 (northern blot) (Vallejo and Leon, 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mcr-PA   FBpp0079165   202.8   1760   6.42     NP_524688   AAF52601
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Alpha-2-macroglobulin, N-terminal (IPR002890) Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (IPR008930) Alpha-macroglobulin, receptor-binding (IPR009048) Alpha-2-macroglobulin, N-terminal 2 (IPR011625) A-macroglobulin complement component (IPR011626) Alpha-2-macroglobulin (IPR001599)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441134   AA540366   AA940947   AA941816   AE014134 AAF52601   AW942672   AY058526 AAL13755   BF498495   BG638108   BG638495   BI232287   BI238333   BI366429   BI369201   BP557996   BP557997   CO185606   CO187745   CO190342   CO192523   CO262542   CO265525   CO266437   CO270990   CO279247   CO284775   CO288028   CO291458   CO292492   CO294112   CO297366   CO299073   CO299681   CO301764   CO306097   CO308401   CO318188   CO319000   CO319293   CO329532   CO332073   CZ486447   CZ486448   EC064456   EC066954   EC070697   EC072859   EC078832   EC085280   EC085489   EC086204   EC086590   EC089600   EC089787   EC201375   EC204483   EC205221   EC207564   EC208141   EC210150   EC210396   EC217328   EC218290   EC226225   EC230379   EC230918   EC234206   EC245342   EC248308   ES694186   EV575666   EV594571   GH748124   GH750232   GH771280   GH775112   GH778876   GH778947   GH785448   GH795576   GH798302   GH803060   GH806005   GH810241   GH812864   GH813311   GH830885   GH834910   GH862486   GH871134   GH873017   GH876188   GH877263   GH882872   GH885271   GH887134   GH907778   GH915414   GH922925   GH924316   GH928566   GH931252   Y11116
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VLT3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system   (Vallejo and Leon, 1989) spermatogenesis & adult stage   testis   (Vallejo and Leon, 1989) spermatocyte   (Vallejo and Leon, 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020240    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020240 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020240 expression level Developmental Stage   Expression Level embryo 00-02hr    3570 embryo 02-04hr    1697 embryo 04-06hr    4723 embryo 06-08hr    8771 embryo 08-10hr    9332 embryo 10-12hr    7758 embryo 12-14hr    8129 embryo 14-16hr    5140 embryo 16-18hr    3765 embryo 18-20hr    2850 embryo 20-22hr    1649 embryo 22-24hr    2008 larva L1    1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6    2051 larva L3 puffstage 7-9    2978 white prepupae new    3041 white prepupae 12hr    2529 white prepupae 24hr    3907 pupae 2d postWPP    3296 pupae 3d postWPP    2697 pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day    1457 adult female 05day    2821 adult female 30day    2679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3570) embryo 02-04hr  (1697) embryo 04-06hr  (4723) embryo 06-08hr  (8771) embryo 08-10hr  (9332) embryo 10-12hr  (7758) embryo 12-14hr  (8129) embryo 14-16hr  (5140) embryo 16-18hr  (3765) embryo 18-20hr  (2850) embryo 20-22hr  (1649) embryo 22-24hr  (2008) larva L1  (1852) larva L2  (1135) larva L3 12hr old  (898) larva L3 puffstage 1-2  (1034) larva L3 puffstage 3-6  (2051) larva L3 puffstage 7-9  (2978) white prepupae new  (3041) white prepupae 12hr  (2529) white prepupae 24hr  (3907) pupae 2d postWPP  (3296) pupae 3d postWPP  (2697) pupae 4d postWPP  (757) adult male 01day  (1001) adult male 05day  (1141) adult male 30day  (1199) adult female 01day  (1457) adult female 05day  (2821) adult female 30day  (2679) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3570) embryo 02-04hr  (1697) embryo 04-06hr  (4723) embryo 06-08hr  (8771) embryo 08-10hr  (9332) embryo 10-12hr  (7758) embryo 12-14hr  (8129) embryo 14-16hr  (5140) embryo 16-18hr  (3765) embryo 18-20hr  (2850) embryo 20-22hr  (1649) embryo 22-24hr  (2008) larva L1  (1852) larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6  (2051) larva L3 puffstage 7-9  (2978) white prepupae new  (3041) white prepupae 12hr  (2529) white prepupae 24hr  (3907) pupae 2d postWPP  (3296) pupae 3d postWPP  (2697) pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day  1457 adult female 05day  (2821) adult female 30day  (2679) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3570 embryo 02-04hr    1697 embryo 04-06hr    4723 embryo 06-08hr    8771 embryo 08-10hr    9332 embryo 10-12hr    7758 embryo 12-14hr    8129 embryo 14-16hr    5140 embryo 16-18hr    3765 embryo 18-20hr    2850 embryo 20-22hr    1649 embryo 22-24hr    2008 larva L1    1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6    2051 larva L3 puffstage 7-9    2978 white prepupae new    3041 white prepupae 12hr    2529 white prepupae 24hr    3907 pupae 2d postWPP    3296 pupae 3d postWPP    2697 pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day    1457 adult female 05day    2821 adult female 30day    2679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3570 embryo 02-04hr    1697 embryo 04-06hr    4723 embryo 06-08hr    8771 embryo 08-10hr    9332 embryo 10-12hr    7758 embryo 12-14hr    8129 embryo 14-16hr    5140 embryo 16-18hr    3765 embryo 18-20hr    2850 embryo 20-22hr    1649 embryo 22-24hr    2008 larva L1    1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6    2051 larva L3 puffstage 7-9    2978 white prepupae new    3041 white prepupae 12hr    2529 white prepupae 24hr    3907 pupae 2d postWPP    3296 pupae 3d postWPP    2697 pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day    1457 adult female 05day    2821 adult female 30day    2679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020240 expression level Developmental Stage   Expression Level embryo 00-02hr    3570 embryo 02-04hr    1697 embryo 04-06hr    4723 embryo 06-08hr    8771 embryo 08-10hr    9332 embryo 10-12hr    7758 embryo 12-14hr    8129 embryo 14-16hr    5140 embryo 16-18hr    3765 embryo 18-20hr    2850 embryo 20-22hr    1649 embryo 22-24hr    2008 larva L1    1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6    2051 larva L3 puffstage 7-9    2978 white prepupae new    3041 white prepupae 12hr    2529 white prepupae 24hr    3907 pupae 2d postWPP    3296 pupae 3d postWPP    2697 pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day    1457 adult female 05day    2821 adult female 30day    2679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3570) embryo 02-04hr  (1697) embryo 04-06hr  (4723) embryo 06-08hr  (8771) embryo 08-10hr  (9332) embryo 10-12hr  (7758) embryo 12-14hr  (8129) embryo 14-16hr  (5140) embryo 16-18hr  (3765) embryo 18-20hr  (2850) embryo 20-22hr  (1649) embryo 22-24hr  (2008) larva L1  (1852) larva L2  (1135) larva L3 12hr old  (898) larva L3 puffstage 1-2  (1034) larva L3 puffstage 3-6  (2051) larva L3 puffstage 7-9  (2978) white prepupae new  (3041) white prepupae 12hr  (2529) white prepupae 24hr  (3907) pupae 2d postWPP  (3296) pupae 3d postWPP  (2697) pupae 4d postWPP  (757) adult male 01day  (1001) adult male 05day  (1141) adult male 30day  (1199) adult female 01day  (1457) adult female 05day  (2821) adult female 30day  (2679) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3570) embryo 02-04hr  1697 embryo 04-06hr  (4723) embryo 06-08hr  (8771) embryo 08-10hr  (9332) embryo 10-12hr  (7758) embryo 12-14hr  (8129) embryo 14-16hr  (5140) embryo 16-18hr  (3765) embryo 18-20hr  (2850) embryo 20-22hr  1649 embryo 22-24hr  2008 larva L1  1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6  2051 larva L3 puffstage 7-9  (2978) white prepupae new  (3041) white prepupae 12hr  (2529) white prepupae 24hr  (3907) pupae 2d postWPP  (3296) pupae 3d postWPP  (2697) pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day  1457 adult female 05day  (2821) adult female 30day  (2679) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3570 embryo 02-04hr    1697 embryo 04-06hr    4723 embryo 06-08hr    8771 embryo 08-10hr    9332 embryo 10-12hr    7758 embryo 12-14hr    8129 embryo 14-16hr    5140 embryo 16-18hr    3765 embryo 18-20hr    2850 embryo 20-22hr    1649 embryo 22-24hr    2008 larva L1    1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6    2051 larva L3 puffstage 7-9    2978 white prepupae new    3041 white prepupae 12hr    2529 white prepupae 24hr    3907 pupae 2d postWPP    3296 pupae 3d postWPP    2697 pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day    1457 adult female 05day    2821 adult female 30day    2679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3570 embryo 02-04hr    1697 embryo 04-06hr    4723 embryo 06-08hr    8771 embryo 08-10hr    9332 embryo 10-12hr    7758 embryo 12-14hr    8129 embryo 14-16hr    5140 embryo 16-18hr    3765 embryo 18-20hr    2850 embryo 20-22hr    1649 embryo 22-24hr    2008 larva L1    1852 larva L2    1135 larva L3 12hr old    898 larva L3 puffstage 1-2    1034 larva L3 puffstage 3-6    2051 larva L3 puffstage 7-9    2978 white prepupae new    3041 white prepupae 12hr    2529 white prepupae 24hr    3907 pupae 2d postWPP    3296 pupae 3d postWPP    2697 pupae 4d postWPP    757 adult male 01day    1001 adult male 05day    1141 adult male 30day    1199 adult female 01day    1457 adult female 05day    2821 adult female 30day    2679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020240    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020240 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval trachea, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020240 expression level Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland    524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop    544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland    528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary    585 Adult Testis    116.1 Adult Male Accessory Gland    561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland  524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop  (544.4) Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland  528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary  (585) Adult Testis    116.1 Adult Male Accessory Gland  (561.1) Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland    524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop    544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland    528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary    585 Adult Testis    116.1 Adult Male Accessory Gland    561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland    524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop    544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland    528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary    585 Adult Testis    116.1 Adult Male Accessory Gland    561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020240 expression level Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland    524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop    544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland    528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary    585 Adult Testis    116.1 Adult Male Accessory Gland    561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland  524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop  544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland  528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary  585 Adult Testis    116.1 Adult Male Accessory Gland  561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland    524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop    544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland    528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary    585 Adult Testis    116.1 Adult Male Accessory Gland    561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    250.1 Larval Midgut    64.4 Larval Hindgut    490.8 Larval Malpighian Tubules    135.6 Larval Fat Body    194.2 Larval Salivary Gland    524.7 Larval Trachea    452.65 Larval Carcass    391.325 Adult Head    334.9 Adult Eye    361.65 Adult Brain    150.6 Adult Thoracic-Abdominal Ganglion    153.9 Adult Crop    544.4 Adult Midgut    54.4 Adult Hindgut    338 Adult Malpighian Tubules    62.5 Adult Fat Body    126.6 Adult Salivary Gland    528.4 Adult Heart    65.975 Adult VirginFemale Spermatheca    267.7 Adult InseminatedFemale Spermatheca    405.5 Adult Ovary    585 Adult Testis    116.1 Adult Male Accessory Gland    561.1 Adult Carcass    193.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    334.9   NA  Eye    361.65   NA  Brain    150.6   250.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    153.9   NA  Crop    544.4   64.4  Midgut    54.4   490.8  Hindgut    338   135.6  Malpighian Tubules    62.5   194.2  Fat Body    126.6   524.7  Salivary Gland    528.4   NA  Heart    65.975   452.65  Trachea    NA   NA  VirginFemale Spermatheca    267.7   NA  InseminatedFemale Spermatheca    405.5   NA  Ovary    585   NA  Testis    116.1   NA  Male Accessory Gland    561.1   391.325  Carcass    193.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020240 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7586-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 McrGD988 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 McrGD988 Phenotype manifest in Allele chaeta, with Scer\GAL4pnr-MD237 McrGD988 trichogen cell, with Scer\GAL4pnr-MD237 McrGD988
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Mcr Class Mutagen Stocks Known lesion McrEY07421 P-element activity 2 -- McrCB-6141-3 1 -- Mcrf03851 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mcr Class Mutagen Stocks Known lesion McrGD988 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes McrKK104742 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7034 (Ryder, 2004.4.26) Df(2L)Trf-C6R31 (Crowley et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD988} NA P{KK104742} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}McrEY07421 NA miscellaneous insertions P{RS3}McrCB-6141-3 NA PBac{WH}Mcrf03851 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
eukaryotic cell surface binding inferred from direct assay (Stroschein-Stevenson et al., 2006) protein binding inferred from physical interaction with egg (Stabell et al., 2006)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) response to yeast inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
endopeptidase inhibitor activity inferred from sequence or structural similarity with UniProtKB:P14046 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular space inferred from electronic annotation with InterPro:IPR011626 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mcr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68813 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020240 DroID - A comprehensive database of gene and protein interactions. • FBgn0020240 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44071
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15134 Dere\GG23478 Dgri\GH10161 Dmoj\GI22464 Dper\GL24751 Dpse\GA20458 Dsec\GM13177 Dsim\GD22442 Dvir\GJ20388 Dwil\GK14802 Dyak\GE11194
Curated drosophilid orthologs	Dpse\GA20458
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012267-PA Aedes aegypti (mosquito) AGAP008407-PA Anopheles gambiae (mosquito) XP_397416.2 Apis mellifera (honey bee) XP_001948864.1 Acyrthosiphon pisum (pea aphid) BGIBMGA004193-PA Bombyx mori (silk worm) 227765 Capitella spl (polychaete worm) 229736 Daphnia pulex (daphnia) 192410 Hypsipyla robusta (cedar shoot borer) ISCW003089-PA Ixodes scapularis (deer tick) 231429 Lottia gigantea (owl limpet) XP_001608105.1 Nasonia vitripennis (wasp) PHUM004993-PA Pediculus humanus (human body louse) Smp_133880 Schistosoma mansoni (trematode parasite) XP_970922.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12837 NV10485 LH24313 ISCW003089 FBgn0229016 FBgn0216807 FBgn0207528 FBgn0193845 FBgn0168108 JGI_V11_229736 FBgn0080453 FBgn0162339 FBgn0145192 FBgn0117642 FBgn0115625 FBgn0092159 BGIBMGA004193 ACYPI010045 GB18789 TEP13 AAEL012267 PHUM289860 GLEAN_09375
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	15997 y1 w67c23; P{EPgy2}McrEY07421/CyO
Harvard	- PBac{WH}Mcrf03851
Kyoto	123945 w1118; P{RS3}McrCB-6141-3 111715 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{EPgy2}McrEY07421 P{neoFRT}40A/CyO y+
VDRC	v100197 P{KK104742}VIE-260B v2785 w1118; P{GD988}v2785
Genomic Clones ( 1 )
	BACR08I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 94 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23292
Other clones	DPiM_LD23292
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD19832 RE28333 RE34749 RE51963 RE55317
Other clones	20134 33123 35285 43318 50309 52178 55472 65298 72040 75130 83215 103864 144565 164957 173328 174363 190716 274553 AT12914 CK01.7B.F6 CK01.59A.B6 CK01.78A.E1 CK01.85B.E2 CK01.101C.A8 CK01.103D.D12 CK01.103D.E1 Dmel_dig_010074_0638_2186 Dmel_neb_013567_0596_3144 EC33959 EK010455 EK032512 EK047830 EK067549 EK079448 EK085725 EK101301 EK133864 EK142855 EK146425 EK166764 EK174441 EK176324 EK182118 EK200314 EK206029 EK216819 EK250247 EK257904 EK270645 EK275741 EK277554 EK293045 EK302441 FGM312D07 LD16028 LD27113 RC0-DL0001-140700-215-A12 RP003002934 RP003021770 RP003022797 RP003040161 RP003087103 RP003097473 RP003129722 RP003136976 RP003150935 RP003169924 RP003193088 RP003234787 RP003260756 RP003275225 RP003304651 RP003305594 RP003332974 RP003343449 RP003345600 RP003356165 RP003359796 RP003426102 RP003438842 RP003441477 RP003480282 RP003493537 RP003510639 RP003564728 RP003605921 RP003674161
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020240 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44071
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mcr CG7586 (Bayraktaroglu, 2000.4.3)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. However, the dsRNA treatment does not affect phagocytosis of either Escherichia coli, Staphylococcus aureus or latex beads. (Stroschein-Stevenson et al., 2006) Transcription unit defined as part of a molecular analysis of Trf. (Crowley et al., 1993) P-element insertions P{lacW}Trf1 and P{lacW}Trf2 (which lie within 50bp of each other at 28D--28E) map approximately 3kb proximal to 3' end of Mcr transcription unit. (Crowley et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079949 RefSeq (Proteins) • NP_524688 DDBJ / EMBL / GenBank • AA940947 AAF52601 AAL13755 AW942672 AY058526 CZ486447 CZ486448 Y11116 Entrez Gene - A searchable database of RefSeq genes. • 44071 UniProtKB/TrEMBL • Q9VLT3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Alpha-2-macroglobulin, N-terminal (IPR002890) Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (IPR008930) Alpha-macroglobulin, receptor-binding (IPR009048) Alpha-2-macroglobulin, N-terminal 2 (IPR011625) A-macroglobulin complement component (IPR011626) Alpha-2-macroglobulin (IPR001599)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68813 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020240 DroID - A comprehensive database of gene and protein interactions. • FBgn0020240 DRSC - Results from RNAi screens. • FBgn0020240 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020240 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7586-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020240 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44071 InParanoid A subset of ortholog calls from InParanoid. • AAEL012267-PA Aedes aegypti (mosquito) AGAP008407-PA Anopheles gambiae (mosquito) XP_397416.2 Apis mellifera (honey bee) XP_001948864.1 Acyrthosiphon pisum (pea aphid) BGIBMGA004193-PA Bombyx mori (silk worm) 227765 Capitella spl (polychaete worm) 229736 Daphnia pulex (daphnia) 192410 Hypsipyla robusta (cedar shoot borer) ISCW003089-PA Ixodes scapularis (deer tick) 231429 Lottia gigantea (owl limpet) XP_001608105.1 Nasonia vitripennis (wasp) PHUM004993-PA Pediculus humanus (human body louse) Smp_133880 Schistosoma mansoni (trematode parasite) XP_970922.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44071 modMine - Data generated by the modENCODE project. • FBgn0020240 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12837 NV10485 LH24313 ISCW003089 FBgn0229016 FBgn0216807 FBgn0207528 FBgn0193845 FBgn0168108 JGI_V11_229736 FBgn0080453 FBgn0162339 FBgn0145192 FBgn0117642 FBgn0115625 FBgn0092159 BGIBMGA004193 ACYPI010045 GB18789 TEP13 AAEL012267 PHUM289860 GLEAN_09375
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-28DE   CG7586 (Anholt and Mackay, 2001, Stabell et al., 2006, Keleman et al., 2009.8.5) Mcr (Anonymous, 2006, Stroschein-Stevenson et al., 2006, Bou Aoun et al., 2008, Choksi et al., 2006) mcr (Guenin et al., 2010) α-2-Mrp
Name Synonym	Macroglobulin complement-related (Crowley, 1997.7.14) Macroglobulin complement related (Anonymous, 2006) α-2-macroglobulin related
Secondary FlyBase IDs
	FBgn0014086 FBgn0031984
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Guenin et al., 2010, BMC Genomics 11: 47 Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. [FBrf0210012] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...