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Gene Dmel\ttv

General Information
Symbol	Dmel\ttv	Species	D. melanogaster
Name	tout-velu	Annotation symbol	CG10117
Feature type	protein_coding_gene	FlyBase ID	FBgn0020245
Gene Model Status	Current	Stock availability	36 publicly available
Also Known As	DEXT1, l(2)05282
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	51A7-51B4	Sequence location	2R:10,414,076..10,472,826 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tout-velu is referred to in FlyBase by the symbol Dmel\ttv (CG10117, FBgn0020245). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; localization; cellular biosynthetic process; primary metabolic process; heparan sulfate proteoglycan biosynthetic process; response to stimulus; cellular macromolecule biosynthetic process; nitrogen compound metabolic process; regulation of cellular process; intracellular distribution of mitochondria. 65 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; trichogen cell; cuticle; macrochaeta; bouton; germline cell; synapse; denticle belt. It has one annotated transcript and one annotated polypeptide. Protein features are: EXTL2, alpha-1,4-N-acetylhexosaminyltransferase; Exostosin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, adult fat body, adult female reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1637442_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ttv. Gene sequence location is 2R:10414076..10472826.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Nishihara, 2010, Methods Enzymol. 480C: 323--351 Dejima et al., 2011, J. Biol. Chem. 286(19): 17103--17111 Sequence features HFA07709 BKN27341
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51A7-51B4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51B5-51B5   (determined by in situ hybridisation)   (Misra, 2000.8.25) 51A2-51B2     (Bellaiche, 1998.8.13) 51B1-51B5   (determined by in situ hybridisation)   (Spradling et al., 1999) 51A-51A   (determined by in situ hybridisation)   (Bellaiche et al., 1998) 51B1-51B5   (determined by in situ hybridisation)   (Perrimon et al., 1996) 51B1-51B2   51B7--8   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Dickson et al., 1995)
Left of (cM)
Right of (cM)	phyl (Dickson et al., 1995)
Notes	36 recombinants in 31,272 progeny. (Dickson et al., 1995)
Gene Model & Products
Please see the GBrowse view of Dmel\ttv for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ttv-RA FBtr0087495  NM_057883   3999   760
Additional Transcript Data & Comments
Reported size (kB)	3.8 (longest cDNA) (Bellaiche et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ttv-PA   FBpp0086624   87.3   760   9.37     NP_477231   AAF58236
Additional Polypeptide Data & Comments
Reported size (kDa)	760 (aa); 80 (kD observed) (Bellaiche et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Exostosin-like (IPR004263) EXTL2, alpha-1,4-N-acetylhexosaminyltransferase (IPR015338)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141426   AA141427   AA141777   AA201422   AA202549   AA203094   AA264876   AA392023   AA392029   AA438478   AA438594   AA538690   AA540291   AE013599 AAF58236   AB221351 BAE78509   AC008306   AF083889 AAC32397   AQ025728   AQ026040   AQ026500   BG637129   BG637790   BG637960   BG638166   BH840616   BI142008   BI164768   BI164834   BI170368   BI215274   BI241338   BI368839   BI369106   BI369493   BI373052   BI373943   BI374059   BI484496   BI565751   BI638731   BP551252   BP551253   BT021403 AAX33551   BT124899   CO276622   CO282348   CO283966   CO284024   CO286247   CO292488   CO321374   CO321403   CO325832   CO338123   CZ467446   CZ468264   CZ468826   CZ470366   CZ474937   CZ479934   CZ479935   CZ481711   CZ485734   EC069981   EC079653   EC197704   EC198462   EC211773   EC222429   EC222555   EC223256   EC234966   EC257767   EC258967   EC261153   EC262518   FE426489   FE426505   FE426569   FE862643   FE863200   GH739718   GH741762   GH742916   GH744455   GH762934   GH779323   GH779635   GH779871   GO254551
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V730
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (The et al., 1999)
Additional Descriptive Data
	Epitope-tagged ttv protein colocalizes with Golgi apparatus marker βCop and endoplasmic reticulum marker Hsc70-3, but not with plasma membrane markers arm or shg, indicating that it is localized to the secretory apparatus, and not to the plasma membrane. (The et al., 1999)
Marker for
Subcellular Localization
CV Term	plasma membrane (Bellaiche et al., 1998)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020245    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020245 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020245 expression level Developmental Stage   Expression Level embryo 00-02hr    1781 embryo 02-04hr    2377 embryo 04-06hr    1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1781) embryo 02-04hr  (2377) embryo 04-06hr  (1827) embryo 06-08hr  (1360) embryo 08-10hr  (1320) embryo 10-12hr  (812) embryo 12-14hr  (1083) embryo 14-16hr  (938) embryo 16-18hr  (811) embryo 18-20hr  (542) embryo 20-22hr  (865) embryo 22-24hr  (949) larva L1  (549) larva L2  (438) larva L3 12hr old  (329) larva L3 puffstage 1-2  (251) larva L3 puffstage 3-6  (467) larva L3 puffstage 7-9  (554) white prepupae new  (654) white prepupae 12hr  (595) white prepupae 24hr  (792) pupae 2d postWPP  (726) pupae 3d postWPP  (484) pupae 4d postWPP  (281) adult male 01day  (349) adult male 05day  (386) adult male 30day  (324) adult female 01day  (744) adult female 05day  (1197) adult female 30day  (1175) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1781) embryo 02-04hr  (2377) embryo 04-06hr  (1827) embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1781 embryo 02-04hr    2377 embryo 04-06hr    1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1781 embryo 02-04hr    2377 embryo 04-06hr    1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020245 expression level Developmental Stage   Expression Level embryo 00-02hr    1781 embryo 02-04hr    2377 embryo 04-06hr    1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1781) embryo 02-04hr  (2377) embryo 04-06hr  (1827) embryo 06-08hr  (1360) embryo 08-10hr  (1320) embryo 10-12hr  (812) embryo 12-14hr  (1083) embryo 14-16hr  (938) embryo 16-18hr  (811) embryo 18-20hr  (542) embryo 20-22hr  (865) embryo 22-24hr  (949) larva L1  (549) larva L2  (438) larva L3 12hr old  (329) larva L3 puffstage 1-2  (251) larva L3 puffstage 3-6  (467) larva L3 puffstage 7-9  (554) white prepupae new  (654) white prepupae 12hr  (595) white prepupae 24hr  (792) pupae 2d postWPP  (726) pupae 3d postWPP  (484) pupae 4d postWPP  (281) adult male 01day  (349) adult male 05day  (386) adult male 30day  (324) adult female 01day  (744) adult female 05day  (1197) adult female 30day  (1175) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1781 embryo 02-04hr  2377 embryo 04-06hr  1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1781 embryo 02-04hr    2377 embryo 04-06hr    1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1781 embryo 02-04hr    2377 embryo 04-06hr    1827 embryo 06-08hr    1360 embryo 08-10hr    1320 embryo 10-12hr    812 embryo 12-14hr    1083 embryo 14-16hr    938 embryo 16-18hr    811 embryo 18-20hr    542 embryo 20-22hr    865 embryo 22-24hr    949 larva L1    549 larva L2    438 larva L3 12hr old    329 larva L3 puffstage 1-2    251 larva L3 puffstage 3-6    467 larva L3 puffstage 7-9    554 white prepupae new    654 white prepupae 12hr    595 white prepupae 24hr    792 pupae 2d postWPP    726 pupae 3d postWPP    484 pupae 4d postWPP    281 adult male 01day    349 adult male 05day    386 adult male 30day    324 adult female 01day    744 adult female 05day    1197 adult female 30day    1175 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020245    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020245 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, adult fat body, adult female reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020245 expression level Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020245 expression level Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    114.9 Larval Midgut    114.3 Larval Hindgut    109.5 Larval Malpighian Tubules    96.5 Larval Fat Body    74.5 Larval Salivary Gland    97.2 Larval Trachea    99.55 Larval Carcass    72.75 Adult Head    66.3 Adult Eye    51.25 Adult Brain    52.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    76.1 Adult Midgut    67.5 Adult Hindgut    59.6 Adult Malpighian Tubules    107.6 Adult Fat Body    147.8 Adult Salivary Gland    62.1 Adult Heart    74 Adult VirginFemale Spermatheca    102.7 Adult InseminatedFemale Spermatheca    107.6 Adult Ovary    245.7 Adult Testis    55.6 Adult Male Accessory Gland    69.3 Adult Carcass    76.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    66.3   NA  Eye    51.25   NA  Brain    52.1   114.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55.1   NA  Crop    76.1   114.3  Midgut    67.5   109.5  Hindgut    59.6   96.5  Malpighian Tubules    107.6   74.5  Fat Body    147.8   97.2  Salivary Gland    62.1   NA  Heart    74   99.55  Trachea    NA   NA  VirginFemale Spermatheca    102.7   NA  InseminatedFemale Spermatheca    107.6   NA  Ovary    245.7   NA  Testis    55.6   NA  Male Accessory Gland    69.3   72.75  Carcass    76.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020245 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10117-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU ttvdsRNA.IR.Scer\UAS lethal (with ttv00681b) ttvG00158 ttvUM-8373-3 lethal (with ttvG00158) ttv00681b lethal (with ttvUM-8373-3) ttv00681b lethal | embryonic stage | fully | rescuable maternal effect ttv00681b lethal | embryonic stage | germline clone | maternal effect ttv02055 lethal | pupal stage ttv00681b lethal | pupal stage, with Scer\GAL4da.G32, ttv00681b ttvScer\UAS.T:Hsap\MYC lethal | pupal stage, with Scer\GAL4da.G32, ttvScer\UAS.T:Hsap\MYC ttv00681b lethal | pupal stage, with Scer\GAL4elav-C155, ttv00681b ttvScer\UAS.T:Hsap\MYC lethal | pupal stage, with Scer\GAL4elav-C155, ttvScer\UAS.T:Hsap\MYC ttv00681b lethal | pupal stage, with Scer\GAL4G14, ttv00681b ttvScer\UAS.T:Hsap\MYC lethal | pupal stage, with Scer\GAL4G14, ttvScer\UAS.T:Hsap\MYC ttv00681b lethal | pupal stage (with ttv205) ttv524 lethal | pupal stage (with ttv524) ttv205 lethal | recessive ttv00681b ttv01901 ttvk00115 ttvk00812 ttvk01106 ttvk03617 ttvk06619 ttvk11904 semi-lethal ttv05282 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ttvGD1993 semi-lethal | recessive ttv05282 viable (with ttv00681b) ttvEX3 ttvEX5 ttvEX16 ttvEX187 ttvEX265 ttvEX296 ttvEX364 viable (with ttv00681b), with Scer\GAL4[-]: ttvEP2199 viable (with ttvEP2199), with Scer\GAL4[-]: ttv00681b viable (with ttvEX3) ttv00681b viable (with ttvEX5) ttv00681b viable (with ttvEX16) ttv00681b viable (with ttvEX187) ttv00681b viable (with ttvEX265) ttv00681b viable (with ttvEX296) ttv00681b viable (with ttvEX364) ttv00681b Other Phenotypes Allele locomotor behavior defective | pupal stage ttv00681b neuroanatomy defective ttv00681b ttv05282 neurophysiology defective | pupal stage ttv00681b visible, with Scer\GAL4pnr-MD237 ttvGD1993 visible | recessive | somatic clone ttv00681b wild-type ttvEX3 ttvEX5 ttvEX16 ttvEX187 ttvEX265 ttvEX296 ttvEX364 ttvhs.PB wild-type, with Scer\GAL4[-]: ttvEP2199 Phenotype manifest in Allele anterior fascicle & bouton ttv00681b ttv05282 bouton ttv00681b bouton, with Scer\GAL4da.G32, ttv00681b ttvScer\UAS.T:Hsap\MYC bouton, with Scer\GAL4da.G32, ttvScer\UAS.T:Hsap\MYC ttv00681b cuticle ttv00681b denticle | ectopic | germline clone | rescuable maternal effect ttv02055 denticle | germline clone | maternal effect ttv00681b denticle belt ttv00681b embryonic/first instar larval cuticle | germline clone ttv00681b embryonic/first instar larval cuticle | germline clone | maternal effect ttv00681b embryonic/first instar larval cuticle | germline clone | rescuable maternal effect | segment polarity expression pattern ttv02055 eye | P-stage (with ttv205) ttv524 eye | P-stage (with ttv524) ttv205 eye | somatic clone ttv00681b germline cell, with Scer\GAL4elav.PLu ttvScer\UAS.T:Hsap\MYC germline cell, with Scer\GAL4ptc-559.1 ttvScer\UAS.T:Hsap\MYC germline cell, with Scer\GAL4wg.PM ttvScer\UAS.T:Hsap\MYC germline cell | non-rescuable maternal effect ttvunspecified imaginal disc | larval stage (with ttv205) ttv524 imaginal disc | larval stage (with ttv524) ttv205 leg | P-stage (with ttv205) ttv524 leg | P-stage (with ttv524) ttv205 macrochaeta ttvBG01109 synapse ttv00681b trichogen cell, with Scer\GAL4pnr-MD237 ttvGD1993 wing | somatic clone ttv205 ttv524 ttv63 wing disc ttv00681b wing disc | larval stage (with ttv205) ttv524 wing disc | larval stage (with ttv524) ttv205 wing margin | somatic clone ttv02055 ttv63 wing margin bristle | ectopic | somatic clone ttv02055 wing vein | somatic clone ttv63 wing vein L3 | somatic clone ttv02055 wing vein L4 | somatic clone ttv02055
Classical Alleles ( 59 )
For All Classical Alleles Show
Allele of ttv Class Mutagen Stocks Known lesion ttvG00158 3 Yes ttvk11904 P-element activity 2 Yes ttv00681b loss of function allele P-element activity 1 Yes ttv5-HA-1202 1 -- ttv5-HA-2742 1 -- ttv5-HA-2825 1 -- ttvc01785 piggyBac transposase 1 -- ttvc02857 piggyBac transposase 1 -- ttvc03806 piggyBac transposase 1 -- ttvc05929 piggyBac transposase 1 -- ttvCB-0299-3 1 -- ttvCB-5224-3 1 -- ttvCB-5522-3 1 -- ttvCB-5671-3 1 -- ttvCB-6304-3 1 -- ttvd02754 1 -- ttvd06136 P-element activity 1 -- ttvDG14305 P-element activity 1 -- ttve02106 piggyBac transposase 1 -- ttve03949 piggyBac transposase 1 -- ttvf03193 piggyBac transposase 1 -- ttvk03617 P-element activity 1 -- ttvk06619 P-element activity 1 -- ttvKG05875 P-element activity 1 -- ttvMI01522 1 -- ttvNP0774 1 -- ttvNP3088 1 -- ttvNP5249 1 -- ttvNP5287 1 -- ttvNP7078 1 -- ttvUM-8279-3 1 -- ttvUM-8373-3 1 Yes ttv01901 P-element activity 0 -- ttv02055 0 -- ttv05282 P-element activity 0 -- ttv205 ethyl methanesulfonate 0 Yes ttv5-HA-2168 0 -- ttv5-HA-2425 0 -- ttv524 ethyl methanesulfonate 0 Yes ttv63 0 Yes ttvB11 P-element activity recombination 0 Yes ttvBG01109 P-element activity 0 Yes ttvEP2142 P-element activity 0 Yes ttvEP2199 P-element activity 0 Yes ttvEP2552 P-element activity 0 Yes ttvEP765 P-element activity 0 Yes ttvEX16 Delta2-3 0 Yes ttvEX187 Delta2-3 0 Yes ttvEX265 Delta2-3 0 Yes ttvEX296 Delta2-3 0 Yes ttvEX364 Delta2-3 0 Yes ttvEX3 Delta2-3 0 Yes ttvEX5 Delta2-3 0 Yes ttvk00115 P-element activity 0 -- ttvk00812 P-element activity 0 -- ttvk01106 P-element activity 0 -- ttvk14904 P-element activity 0 -- ttvNP4633 0 -- ttvunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ttv Class Mutagen Stocks Known lesion ttvGD1993 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ttvAct5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttvdsRNA.cLa in vitro construct - RNAi 0 Yes ttvdsRNA.IR.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ttvhs.PB in vitro construct - regulatory fusion 0 Yes ttvScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)03072 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Bischoff et al., 2009) Df(2R)BSC668 (Christensen et al., 2008.12.28) Df(2R)trix (Bellaiche et al., 1998, Spradling et al., 1999, Schulze et al., 2005, BDGP Project Members, 1994-1999, Dickson et al., 1995)
Partially disrupted in	Df(2L)LamCEX187 (Schulze et al., 2005) Df(2L)LamCEX296 (Schulze et al., 2005)
Not disrupted in	Df(2L)LamCEX187 (Schulze et al., 2005) Df(2L)LamCEX296 (Schulze et al., 2005) Df(3R)2-2 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-ttv.B} NA UAS construct P{GD1993} NA P{UAS-ttv.IR} NA P{UAS-ttv.myc} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0161SH0161 No P{lacW}ttvk00115 No P{lacW}ttvk00812 No P{lacW}ttvk01106 No P{lacW}ttvk03617 No P{lacW}ttvk06619 No P{lacW}ttvk11904 No P{lacW}ttvk14904 No P{PZ}ttv00681b No P{PZ}ttv01901 No P{PZ}ttv05282 No insertion of mobile activating element P{EP}LamCEP2142 NA P{EP}LamCEP2199 NA P{EP}LamCEP2552 NA P{EP}ttvEP765 NA P{XP}LamCd04234 NA P{XP}ttvd02754 NA P{XP}ttvd06136 NA miscellaneous insertions Mi{MIC}ttvMI01522 NA P{?PTT-GB}LamCEX3 NA P{?PTT-GB}LamCEX5 NA P{?PTT-GB}LamCEX16 NA P{?PTT-GB}LamCEX187 NA P{?PTT-GB}LamCEX265 NA P{?PTT-GB}LamCEX364 NA P{GT1}ttvBG01109 NA P{PTT-GB}LamCG00158 NA P{RS3}LamCUM-8373-3 NA P{RS3}ttvCB-0299-3 NA P{RS3}ttvCB-5224-3 NA P{RS3}ttvCB-5522-3 NA P{RS3}ttvCB-5671-3 NA P{RS3}ttvCB-6304-3 NA P{RS3}ttvUM-8279-3 NA P{RS5}ttv5-HA-1202 NA P{RS5}ttv5-HA-2168 NA P{RS5}ttv5-HA-2425 NA P{RS5}ttv5-HA-2742 NA P{RS5}ttv5-HA-2825 NA P{SUPor-P}ttvKG05875 NA P{wHy}LamCDG14305 NA PBac{PB}ttvc01785 NA PBac{PB}ttvc02857 NA PBac{PB}ttvc03806 NA PBac{PB}ttvc05929 NA PBac{RB}ttve02106 NA PBac{RB}ttve03949 NA PBac{WH}ttvf03193 NA insertion of enhancer trap binary system P{GawB}ttvNP0774 No P{GawB}ttvNP3088 No P{GawB}ttvNP4633 No P{GawB}ttvNP5249 No P{GawB}ttvNP5287 No P{GawB}ttvNP7078 No
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Ext2 (assigned by UniProtKB) (Han et al., 2004)
Biological Process
CV term Evidence References
decapentaplegic signaling pathway inferred from mutant phenotype (Bornemann et al., 2004) inferred from mutant phenotype (assigned by UniProtKB) (Han et al., 2004) germ cell migration inferred from mutant phenotype (Deshpande et al., 2007) glycosaminoglycan biosynthetic process inferred from mutant phenotype (Bornemann et al., 2004) inferred from mutant phenotype (assigned by UniProtKB) (Toyoda et al., 2000, Toyoda et al., 2000) heparan sulfate proteoglycan biosynthetic process inferred from direct assay (Izumikawa et al., 2006) inferred from mutant phenotype (Kim et al., 2002, Ren et al., 2009) inferred from mutant phenotype (assigned by UniProtKB) (The et al., 1999) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process inferred from mutant phenotype (Takei et al., 2004) heparin biosynthetic process inferred from mutant phenotype (Bornemann et al., 2004) intracellular distribution of mitochondria inferred from mutant phenotype (Ren et al., 2009) regulation of smoothened signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Bellaiche et al., 1998, Gallet et al., 2003) smoothened signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Han et al., 2004) synapse organization inferred from mutant phenotype (Ren et al., 2009) synaptic vesicle endocytosis inferred from mutant phenotype (Ren et al., 2009) Wnt receptor signaling pathway inferred from genetic interaction with Ext2 (assigned by UniProtKB) (Han et al., 2004) inferred from mutant phenotype (Bornemann et al., 2004)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from direct assay (assigned by UniProtKB) (The et al., 1999, Han et al., 2004) Golgi apparatus inferred from direct assay (assigned by UniProtKB) (The et al., 1999, Han et al., 2004)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
acetylglucosaminyltransferase activity inferred from sequence or structural similarity with EMBL:AF089748 (FlyBase, 1992-) non-traceable author statement (Wilson, 2002) glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity inferred from sequence or structural similarity with UniProtKB:O77783 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.5.1) glucuronosyltransferase activity non-traceable author statement (Wilson, 2002) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity inferred from sequence or structural similarity with UniProtKB:O77783 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.5.1)
Biological Process
CV term Evidence References
heparan sulfate proteoglycan biosynthetic process non-traceable author statement (Wilson, 2002) traceable author statement (Mann and Beachy, 2000, Park et al., 2000) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process non-traceable author statement (Perrimon and Bernfield, 2000) N-acetylglucosamine metabolic process inferred from sequence or structural similarity with UniProtKB:O77783 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.5.1) smoothened signaling pathway non-traceable author statement (Nybakken and Perrimon, 2002)
Cellular Component
CV term Evidence References
integral to membrane non-traceable author statement (assigned by UniProtKB) (Bellaiche et al., 1998) intrinsic to endoplasmic reticulum membrane inferred from electronic annotation with InterPro:IPR015338 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ttv allele Gene References ttv00681b hh (Gallet et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62362 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020245 DroID - A comprehensive database of gene and protein interactions. • FBgn0020245 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36614
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13249 Dere\GG20465 Dgri\GH20787 Dmoj\GI20872 Dper\GL11446 Dpse\GA10084 Dsec\GM21554 Dsim\GD11060 Dvir\GJ20607 Dwil\GK15839 Dyak\GE13596
Curated drosophilid orthologs	Dpse\GA10084
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003533-PA Aedes aegypti (mosquito) AGAP010388-PA Anopheles gambiae (mosquito) XP_391845.2 Apis mellifera (honey bee) XP_001951081.1 Acyrthosiphon pisum (pea aphid) BGIBMGA003727-PA Bombyx mori (silk worm) ENSBTAP00000008154 Bos taurus (bovine) ENSCAFP00000001191 Canis familiaris (dog) ENSCINP00000013351 Ciona intestinalis (sea squirt) ENSCPOP00000011724 Cavia porcellus (guinea pig) ENSCSAVP00000012420 Ciona savignyi (sedentary tunicate) 92231 Capitella spl (polychaete worm) 304945 Daphnia pulex (daphnia) ENSDARP00000003397 Danio rerio (zebra fish) ENSECAP00000020753 Equus caballus (horse) ENSGACP00000009174 Gymnopilus aculeatus (mushroom) ENSGALP00000025918 Gallus gallus (chicken) 119925 Hypsipyla robusta (cedar shoot borer) ENSP00000367446 Homo sapiens (human) 199269 Lottia gigantea (owl limpet) ENSMODP00000005034 Monodelphis domestica (gray opossum) ENSMMUP00000011329 Macaca mulatta (rhesus monkey) ENSMUSP00000076505 Mus musculus (house mouse) 173450 Nematostella vectensis (starlet anemone) XP_001603840.1 Nasonia vitripennis (wasp) ENSOANP00000020397 Ornithorynchus anatinus (platypus) ENSORLP00000007001 Oryzias latipes (japanese killifish) PHUM000044-PA Pediculus humanus (human body louse) PP28672 Pristionchus pacificus (nematode) ENSPPYP00000021133 Pongo pygmaeus (orangutan) ENSPTRP00000035108 Pan troglodytes (chimpanzee) ENSRNOP00000031943 Rattus norvegicus (norway rat) Smp_172060 Schistosoma mansoni (trematode parasite) XP_001176764.1 Strongylocentrotus purpuratus (purple sea urchin) 1026 Trichoplax adhaerens (metazoa) XP_968944.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022303 Tetraodon nigroviridis (green spotted pufferfish) 263396 Thalassiosira pseudonana (marine diatom) ENSTRUP00000015505 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000041488 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16807 NV15289 LH21456 ISCW021389 FBgn0231258 FBgn0217842 FBgn0207746 FBgn0182820 FBgn0176434 JGI_V11_304945 FBgn0070143 FBgn0149055 FBgn0143606 FBgn0128250 FBgn0112655 FBgn0090281 BGIBMGA003727 ACYPI008556 GB17343 AGAP010388 AAEL003533 PHUM455050 GLEAN_04758
Stocks & Reagents
Stocks Listed in FlyBase ( 36 )
Harvard	- P{XP}ttvd02754 - P{XP}ttvd06136 - PBac{PB}ttvc01785 - PBac{PB}ttvc02857 - PBac{PB}ttvc03806 - PBac{PB}ttvc05929 - PBac{RB}ttve02106 - PBac{RB}ttve03949 - PBac{WH}ttvf03193
Kyoto	110612 P{PTT-GB}LamCG00158 123114 w1118; P{RS3}ttvCB-0299-3
VDRC	v4871 w1118; P{GD1993}v4871
	More stocks available...
Genomic Clones ( 2 )
	BACR06D02 BACR27M04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10920
Other clones	DPiM_LD10920 MIP20656
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03594 LD04489 LD09555 LD10959 LD10966 LD12905 LD19740 RE04512 RE04583 RE11780 RE21632 RE38376 RE54882 RE55182 RE55689 RE60264 RE61412 RE61571 RE67611 RH63565 SD14990 SD15993 SD21094
Other clones	976 29975 44085 46065 59213 60783 62008 214471.69 214501.65 525656 569971 CK01.80B.G7 CK01.113C.F4 CK01724 CK02423 EK062228 EK121639 EK160260 EK164920 EK165049 EK185546 EK185619 EK200306 EN16010 EP02622 FGM211H03 LD04003 LD10385 LD18275 RM05141 RM05241 RM05441 RM05641 RM06441 RP01033 RP001012746 RP001017426 RP001021430 RP001040904 RP001045105 RP001046398 RP001047803 RP001048758
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020245 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36614
Antibody Information
	polyclonal (The et al., 1999)
Other Information
Discoverer
Etymology
	'tout-velu' means 'all hair' in French. (Bellaiche et al., 1998)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ttv l(2)00681 (Bellaiche et al., 1998) Source for merge of: ttv l(2)05282 l(2)k03617 (Beaton, 1999.12.12)
Additional comments
Other Comments
	ttv is required for normal germ cell migration in the developing embryo. (Deshpande et al., 2007) ttv is necessary for normal levels of heparan sulphate glycosaminoglycan modification of dally and dlp gene products. (Han et al., 2004) ttv is required for transport of morphogens (hh, wg, and dpp) in the developing imaginal discs. (Takei et al., 2004) ttv is involved in heparan sulfate proteoglycan synthesis. (The et al., 1999) ttv is required for the diffusion of the hh gene product. ttv is a member of the EXT gene family. (Bellaiche et al., 1998) Mutants show maternal effect segment polarity phenotypes. (Bellaiche et al., 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) Isolated in a screen for lethal mutations affecting segmentation. (Bellaiche et al., 1997) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057883 RefSeq (Proteins) • NP_477231 DDBJ / EMBL / GenBank • AAC32397 AAF58236 AAX33551 AB221351 AC008306 AF083889 AQ025728 AQ026040 AQ026500 BAE78509 BH840616 BT021403 CZ467446 CZ468264 CZ468826 CZ470366 CZ474937 CZ479934 CZ479935 CZ481711 CZ485734 Entrez Gene - A searchable database of RefSeq genes. • 36614 UniProtKB/TrEMBL • Q9V730
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Exostosin-like (IPR004263) EXTL2, alpha-1,4-N-acetylhexosaminyltransferase (IPR015338)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62362 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020245 DroID - A comprehensive database of gene and protein interactions. • FBgn0020245 DRSC - Results from RNAi screens. • FBgn0020245 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020245 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10117-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020245 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36614 InParanoid A subset of ortholog calls from InParanoid. • AAEL003533-PA Aedes aegypti (mosquito) AGAP010388-PA Anopheles gambiae (mosquito) XP_391845.2 Apis mellifera (honey bee) XP_001951081.1 Acyrthosiphon pisum (pea aphid) BGIBMGA003727-PA Bombyx mori (silk worm) ENSBTAP00000008154 Bos taurus (bovine) ENSCAFP00000001191 Canis familiaris (dog) ENSCINP00000013351 Ciona intestinalis (sea squirt) ENSCPOP00000011724 Cavia porcellus (guinea pig) ENSCSAVP00000012420 Ciona savignyi (sedentary tunicate) 92231 Capitella spl (polychaete worm) 304945 Daphnia pulex (daphnia) ENSDARP00000003397 Danio rerio (zebra fish) ENSECAP00000020753 Equus caballus (horse) ENSGACP00000009174 Gymnopilus aculeatus (mushroom) ENSGALP00000025918 Gallus gallus (chicken) 119925 Hypsipyla robusta (cedar shoot borer) ENSP00000367446 Homo sapiens (human) 199269 Lottia gigantea (owl limpet) ENSMODP00000005034 Monodelphis domestica (gray opossum) ENSMMUP00000011329 Macaca mulatta (rhesus monkey) ENSMUSP00000076505 Mus musculus (house mouse) 173450 Nematostella vectensis (starlet anemone) XP_001603840.1 Nasonia vitripennis (wasp) ENSOANP00000020397 Ornithorynchus anatinus (platypus) ENSORLP00000007001 Oryzias latipes (japanese killifish) PHUM000044-PA Pediculus humanus (human body louse) PP28672 Pristionchus pacificus (nematode) ENSPPYP00000021133 Pongo pygmaeus (orangutan) ENSPTRP00000035108 Pan troglodytes (chimpanzee) ENSRNOP00000031943 Rattus norvegicus (norway rat) Smp_172060 Schistosoma mansoni (trematode parasite) XP_001176764.1 Strongylocentrotus purpuratus (purple sea urchin) 1026 Trichoplax adhaerens (metazoa) XP_968944.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022303 Tetraodon nigroviridis (green spotted pufferfish) 263396 Thalassiosira pseudonana (marine diatom) ENSTRUP00000015505 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000041488 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/toutvelu1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36614 modMine - Data generated by the modENCODE project. • FBgn0020245 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16807 NV15289 LH21456 ISCW021389 FBgn0231258 FBgn0217842 FBgn0207746 FBgn0182820 FBgn0176434 JGI_V11_304945 FBgn0070143 FBgn0149055 FBgn0143606 FBgn0128250 FBgn0112655 FBgn0090281 BGIBMGA003727 ACYPI008556 GB17343 AGAP010388 AAEL003533 PHUM455050 GLEAN_04758
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG10117 (Norga et al., 2003, Mount, 2001.8.14, Kraut et al., 2001, Kraut et al., 2001, Izumikawa et al., 2006) DEXT1 (Wilson, 2002, Izumikawa et al., 2006, Nishihara, 2010) Ext1 (Wilson and Chuang, 2006) l(2)00681 (Spradling et al., 1999, ) l(2)05282 (Berkeley Drosophila Genome Project, 1993.6.1, BDGP Project Members, 1994-1999, ) l(2)k00115   l(2)k03617 (BDGP Project Members, 1994-1999, ) P1.15 (Dickson et al., 1995) ttv (Briscoe and Therond, 2005, Gorfinkiel et al., 2005, Izumikawa et al., 2006, Yao et al., 2006, Gallet et al., 2006, Christensen and Cook, 2007.10.29, Deshpande et al., 2007, Wilson and Chuang, 2006, Wendler et al., 2006, Ueyama et al., 2008, Torroja et al., 2005, Dasgupta et al., 2007, Christensen et al., 2008.12.28, Callejo et al., 2006, Eugster et al., 2007, Bornemann et al., 2008, Renault et al., 2009, Ren et al., 2009, Chanana et al., 2009, Glise et al., 2005, Hayashi et al., 2009, Bischoff et al., 2009, Belenkaya et al., 2008, Pospisilik et al., 2010, Baron et al., 2009, Wang et al., 2011, The et al., 1999, Nishihara, 2010, Dejima et al., 2011) Ttv (Gallet et al., 2006)
Name Synonym	tout velu (Kuwabara and Labouesse, 2002, Mann and Beachy, 2000, The et al., 1998, Torroja et al., 2005, Dasgupta et al., 2007, Bischoff et al., 2009) tout-velu (Kraut et al., 2001, Kraut et al., 2001, Bellaiche, 1998.8.13, Bellaiche et al., 1997, Izumikawa et al., 2006, Eldar and Barkai, 2005, Wilson and Chuang, 2006, Wendler et al., 2006, Eugster et al., 2007, Bornemann et al., 2008, Chanana et al., 2009, Hayashi et al., 2009, The et al., 1999) Tout velu (Gallet et al., 2006) toutvelu (Deshpande et al., 2007)
Secondary FlyBase IDs
	FBgn0010469 FBgn0010592 FBgn0024670
References ( 136 )
Generate a list of	All references relating to this gene ( 136 )
List References by type	Research paper  ( 53 ) Supplementary material  ( 5 ) Review  ( 35 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 18 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Meeting report  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 3 )
Recent research papers ( 4 )
	Dejima et al., 2011, J. Biol. Chem. 286(19): 17103--17111 Novel Contact-dependent Bone Morphogenetic Protein (BMP) Signaling Mediated by Heparan Sulfate Proteoglycans. [FBrf0213647] Wang et al., 2011, Infect. Immun. 79(2): 606--616 Host and Pathogen Glycosaminoglycan-Binding Proteins Modulate Antimicrobial Peptide Responses in Drosophila melanogaster. [FBrf0212806] Nishihara, 2010, Methods Enzymol. 480C: 323--351 Glycosyltransferases and Transporters that Contribute to Proteoglycan Synthesis in Drosophila Identification and Functional Analyses Using the Heritable and Inducible RNAi System. [FBrf0211722] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...