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Gene Dmel\ran

General Information
Symbol	Dmel\ran	Species	D. melanogaster
Name	ran	Annotation symbol	CG1404
Feature type	protein_coding_gene	FlyBase ID	FBgn0020255
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(1)G0075
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10A8-10A8	Sequence location	X:11,038,909..11,042,622 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ran is referred to in FlyBase by the symbol Dmel\ran (CG1404, FBgn0020255). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTP binding; protein binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; cell adhesion; cell cycle; actin filament organization. 9 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; photoreceptor cell; cone cell; ommatidium; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ran GTPase; Small GTP-binding protein domain; Small GTPase superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1637015_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of ran. Gene sequence location is X:11038909..11042622.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Sequence features BKN28549 HFA20364
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A8-10A8   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10A7-10A9   (determined by in situ hybridisation)   (Koizumi et al., 2001) 10A-10A     (Frasch, 2000.2.11) 10A4-10A9   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 9D-9D   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29) 10A7-10A9     (Stivers et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ran for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ran-RA FBtr0073472  NM_143712   1625   216 ran-RB FBtr0073471  NM_167272   1136   216
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ran-PA   FBpp0073328   24.7   216   7.96     NP_651969   AAF48008 ran-PB   FBpp0073327   24.7   216   7.96     NP_727499   AAN09287
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ran GTPase (IPR002041) Small GTP-binding protein domain (IPR005225) Small GTPase superfamily (IPR001806)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201307   AA201452   AA201719   AA201794   AA202110   AA202365   AA202640   AA203044   AA246876   AA263247   AA263966   AA264179   AA264282   AA264293   AA264483   AA264541   AA390472   AA390836   AA390939   AA391821   AA392489   AA393016   AA440248   AA440581   AA538666   AA539727   AA539926   AA540001   AA540694   AA540753   AA567081   AA567262   AA695146   AA695814   AA695903   AA696443   AA698727   AA735712   AA801634   AA803259   AA803334   AA803335   AA803818   AA816303   AA816511   AA821040   AA940853   AA949278   AA949301   AA950335   AA951444   AA951470   AA951574   AA951668   AA951725   AA951853   AA951870   AA951891   AA952286   AA979041   AA990635   AA990714   AA990716   AE014298 AAF48008   AE014298 AAN09287   AF220950 AAF30287   AF233584 AAF60289   AF233585 AAF60290   AI062398   AI107231   AI135242   AI257929   AI257978   AI258571   AI292520   AI456134   AI457037   AI511663   AI511786   AI512928   AI516188   AI516812   AI518094   AI518720   AI519004   AI519044   AI519522   AI520541   AI520553   AI520597   AI543987   AI546115   AI546444   AI546477   AI546510   AJ426854   AK339964   AK339965   AW943135   AY061398 AAL28946   AY070533 AAL48004   AY232185   BE976876   BE977213   BE977807   BF488197   BF489351   BF490219   BF491588   BF494684   BF495119   BF496405   BF496706   BF502389   BF503865   BF504806   BG634882   BI162133   BI162134   BI163189   BI163771   BI164315   BI164466   BI166079   BI168042   BI170455   BI170701   BI170878   BI170915   BI171960   BI172334   BI172705   BI172866   BI173595   BI212151   BI212285   BI213160   BI213391   BI215415   BI215854   BI216116   BI216478   BI227870   BI230166   BI230703   BI230767   BI231696   BI232753   BI233241   BI234701   BI235204   BI235262   BI235374   BI235485   BI235746   BI236136   BI236188   BI236459   BI237042   BI238040   BI240360   BI241313   BI241552   BI241866   BI242265   BI243787   BI351873   BI351952   BI352377   BI352767   BI353332   BI353485   BI355034   BI356366   BI356568   BI357734   BI361700   BI362375   BI363389   BI363555   BI364973   BI366502   BI367088   BI368135   BI368888   BI368915   BI371165   BI372534   BI373762   BI374769   BI375858   BI481533   BI481993   BI482497   BI482754   BI483022   BI483048   BI483155   BI483190   BI483265   BI483803   BI484080   BI484818   BI486562   BI486735   BI487229   BI567522   BI570844   BI571636   BI572328   BI572335   BI574067   BI574068   BI574397   BI576224   BI576368   BI577494   BI579110   BI580343   BI580924   BI582236   BI584478   BI584919   BI585417   BI587426   BI592478   BI607825   BI610228   BI613711   BI615719   BI615886   BI623192   BI624948   BI632702   BI635715   BI636168   BI638487   BI639490   BI640076   BP542416   BP547617   BP552334   BP553492   BP553493   BP554158   BP555044   BP555045   BP555079   BP555080   BP556090   BP556091   BP558165   BP558166   BQ103029   BQ103033   BT003574 AAO39578   BX016048   BX031280   BX037177   BX039401   BX044267   BX047537   BX055515   BX065836   BX071159   CK604415   CK604416   CK604618   CK604619   CK604651   CK604652   CK657563   CK657940   CK659006   CL527823   CO154387   CO154462   CO155135   CO155244   CO155317   CO156084   CO182969   CO185336   CO192294   CO196077   CO262666   CO264938   CO301206   CO312599   CO317604   CO317623   CO319089   CO335697   CO336283   CO338315   EC056699   EC056756   EC056872   EC061350   EC061723   EC074209   EC077632   EC083836   EC194905   EC196696   EC197254   EC203378   EC204179   EC224070   EC231076   EC233212   EC238997   EC260969   EC261073   EC261182   EC261649   EC261848   EC262001   EC262094   EC263760   EC265923   EC266543   EC266853   ES688945   ES689086   EV574815   EV576521   EV583441   EV583948   EV592105   EV595917   EV596249   EV597104   EV597574   EV598868   EV598911
UniProtKB/Swiss-Prot	Q9VZ23
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   • spindle (Trieselmann and Wilde, 2002) Comment:mitosis organism   • nucleus & nuclear membrane (Trieselmann and Wilde, 2002) Comment:interphase mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Expression of ranprotein was inferred by the localization of human rhodamine labeled Ran injected into embryos. The protein was partially excluded from the chromatin. Based on the localization of mutant proteins locked into either the GTP or GDP bound states it was concluded that the majority of the labeled ran protein injected into the embryo was bound to GTP. (Trieselmann and Wilde, 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020255    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020255 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020255 expression level Developmental Stage   Expression Level embryo 00-02hr    52170 embryo 02-04hr    76165 embryo 04-06hr    77944 embryo 06-08hr    50204 embryo 08-10hr    43836 embryo 10-12hr    29535 embryo 12-14hr    23557 embryo 14-16hr    23359 embryo 16-18hr    16451 embryo 18-20hr    7580 embryo 20-22hr    10080 embryo 22-24hr    10972 larva L1    24978 larva L2    24469 larva L3 12hr old    16936 larva L3 puffstage 1-2    12817 larva L3 puffstage 3-6    15272 larva L3 puffstage 7-9    19375 white prepupae new    17606 white prepupae 12hr    17406 white prepupae 24hr    17461 pupae 2d postWPP    13275 pupae 3d postWPP    8624 pupae 4d postWPP    12904 adult male 01day    9313 adult male 05day    9625 adult male 30day    11794 adult female 01day    30539 adult female 05day    37304 adult female 30day    35168 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (52170) embryo 02-04hr  (76165) embryo 04-06hr  (77944) embryo 06-08hr  (50204) embryo 08-10hr  (43836) embryo 10-12hr  (29535) embryo 12-14hr  (23557) embryo 14-16hr  (23359) embryo 16-18hr  (16451) embryo 18-20hr  (7580) embryo 20-22hr  (10080) embryo 22-24hr  (10972) larva L1  (24978) larva L2  (24469) larva L3 12hr old  (16936) larva L3 puffstage 1-2  (12817) larva L3 puffstage 3-6  (15272) larva L3 puffstage 7-9  (19375) white prepupae new  (17606) white prepupae 12hr  (17406) white prepupae 24hr  (17461) pupae 2d postWPP  (13275) pupae 3d postWPP  (8624) pupae 4d postWPP  (12904) adult male 01day  (9313) adult male 05day  (9625) adult male 30day  (11794) adult female 01day  (30539) adult female 05day  (37304) adult female 30day  (35168) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52170) embryo 02-04hr  (76165) embryo 04-06hr  (77944) embryo 06-08hr  (50204) embryo 08-10hr  (43836) embryo 10-12hr  (29535) embryo 12-14hr  (23557) embryo 14-16hr  (23359) embryo 16-18hr  (16451) embryo 18-20hr  (7580) embryo 20-22hr  (10080) embryo 22-24hr  (10972) larva L1  (24978) larva L2  (24469) larva L3 12hr old  (16936) larva L3 puffstage 1-2  (12817) larva L3 puffstage 3-6  (15272) larva L3 puffstage 7-9  (19375) white prepupae new  (17606) white prepupae 12hr  (17406) white prepupae 24hr  (17461) pupae 2d postWPP  (13275) pupae 3d postWPP  (8624) pupae 4d postWPP  (12904) adult male 01day  (9313) adult male 05day  (9625) adult male 30day  (11794) adult female 01day  (30539) adult female 05day  (37304) adult female 30day  (35168) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (52170) embryo 02-04hr  (76165) embryo 04-06hr  (77944) embryo 06-08hr  (50204) embryo 08-10hr  (43836) embryo 10-12hr  (29535) embryo 12-14hr  (23557) embryo 14-16hr  (23359) embryo 16-18hr  (16451) embryo 18-20hr    7580 embryo 20-22hr  10080 embryo 22-24hr  (10972) larva L1  (24978) larva L2  (24469) larva L3 12hr old  (16936) larva L3 puffstage 1-2  (12817) larva L3 puffstage 3-6  (15272) larva L3 puffstage 7-9  (19375) white prepupae new  (17606) white prepupae 12hr  (17406) white prepupae 24hr  (17461) pupae 2d postWPP  (13275) pupae 3d postWPP    8624 pupae 4d postWPP  (12904) adult male 01day    9313 adult male 05day    9625 adult male 30day  (11794) adult female 01day  (30539) adult female 05day  (37304) adult female 30day  (35168) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52170 embryo 02-04hr    76165 embryo 04-06hr    77944 embryo 06-08hr    50204 embryo 08-10hr    43836 embryo 10-12hr    29535 embryo 12-14hr    23557 embryo 14-16hr    23359 embryo 16-18hr    16451 embryo 18-20hr    7580 embryo 20-22hr    10080 embryo 22-24hr    10972 larva L1    24978 larva L2    24469 larva L3 12hr old    16936 larva L3 puffstage 1-2    12817 larva L3 puffstage 3-6    15272 larva L3 puffstage 7-9    19375 white prepupae new    17606 white prepupae 12hr    17406 white prepupae 24hr    17461 pupae 2d postWPP    13275 pupae 3d postWPP    8624 pupae 4d postWPP    12904 adult male 01day    9313 adult male 05day    9625 adult male 30day    11794 adult female 01day    30539 adult female 05day    37304 adult female 30day    35168 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020255 expression level Developmental Stage   Expression Level embryo 00-02hr    52170 embryo 02-04hr    76165 embryo 04-06hr    77944 embryo 06-08hr    50204 embryo 08-10hr    43836 embryo 10-12hr    29535 embryo 12-14hr    23557 embryo 14-16hr    23359 embryo 16-18hr    16451 embryo 18-20hr    7580 embryo 20-22hr    10080 embryo 22-24hr    10972 larva L1    24978 larva L2    24469 larva L3 12hr old    16936 larva L3 puffstage 1-2    12817 larva L3 puffstage 3-6    15272 larva L3 puffstage 7-9    19375 white prepupae new    17606 white prepupae 12hr    17406 white prepupae 24hr    17461 pupae 2d postWPP    13275 pupae 3d postWPP    8624 pupae 4d postWPP    12904 adult male 01day    9313 adult male 05day    9625 adult male 30day    11794 adult female 01day    30539 adult female 05day    37304 adult female 30day    35168 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (52170) embryo 02-04hr  (76165) embryo 04-06hr  (77944) embryo 06-08hr  (50204) embryo 08-10hr  (43836) embryo 10-12hr  (29535) embryo 12-14hr  (23557) embryo 14-16hr  (23359) embryo 16-18hr  (16451) embryo 18-20hr  (7580) embryo 20-22hr  (10080) embryo 22-24hr  (10972) larva L1  (24978) larva L2  (24469) larva L3 12hr old  (16936) larva L3 puffstage 1-2  (12817) larva L3 puffstage 3-6  (15272) larva L3 puffstage 7-9  (19375) white prepupae new  (17606) white prepupae 12hr  (17406) white prepupae 24hr  (17461) pupae 2d postWPP  (13275) pupae 3d postWPP  (8624) pupae 4d postWPP  (12904) adult male 01day  (9313) adult male 05day  (9625) adult male 30day  (11794) adult female 01day  (30539) adult female 05day  (37304) adult female 30day  (35168) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52170) embryo 02-04hr  (76165) embryo 04-06hr  (77944) embryo 06-08hr  (50204) embryo 08-10hr  (43836) embryo 10-12hr  (29535) embryo 12-14hr  (23557) embryo 14-16hr  (23359) embryo 16-18hr  (16451) embryo 18-20hr  (7580) embryo 20-22hr  (10080) embryo 22-24hr  (10972) larva L1  (24978) larva L2  (24469) larva L3 12hr old  (16936) larva L3 puffstage 1-2  (12817) larva L3 puffstage 3-6  (15272) larva L3 puffstage 7-9  (19375) white prepupae new  (17606) white prepupae 12hr  (17406) white prepupae 24hr  (17461) pupae 2d postWPP  (13275) pupae 3d postWPP  (8624) pupae 4d postWPP  (12904) adult male 01day  (9313) adult male 05day  (9625) adult male 30day  (11794) adult female 01day  (30539) adult female 05day  (37304) adult female 30day  (35168) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (52170) embryo 02-04hr  (76165) embryo 04-06hr  (77944) embryo 06-08hr  (50204) embryo 08-10hr  (43836) embryo 10-12hr  (29535) embryo 12-14hr  (23557) embryo 14-16hr  (23359) embryo 16-18hr  16451 embryo 18-20hr    7580 embryo 20-22hr  10080 embryo 22-24hr  10972 larva L1  (24978) larva L2  (24469) larva L3 12hr old  16936 larva L3 puffstage 1-2  12817 larva L3 puffstage 3-6  15272 larva L3 puffstage 7-9  19375 white prepupae new  17606 white prepupae 12hr  17406 white prepupae 24hr  17461 pupae 2d postWPP  13275 pupae 3d postWPP    8624 pupae 4d postWPP  12904 adult male 01day    9313 adult male 05day    9625 adult male 30day  11794 adult female 01day  (30539) adult female 05day  (37304) adult female 30day  (35168) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52170 embryo 02-04hr    76165 embryo 04-06hr    77944 embryo 06-08hr    50204 embryo 08-10hr    43836 embryo 10-12hr    29535 embryo 12-14hr    23557 embryo 14-16hr    23359 embryo 16-18hr    16451 embryo 18-20hr    7580 embryo 20-22hr    10080 embryo 22-24hr    10972 larva L1    24978 larva L2    24469 larva L3 12hr old    16936 larva L3 puffstage 1-2    12817 larva L3 puffstage 3-6    15272 larva L3 puffstage 7-9    19375 white prepupae new    17606 white prepupae 12hr    17406 white prepupae 24hr    17461 pupae 2d postWPP    13275 pupae 3d postWPP    8624 pupae 4d postWPP    12904 adult male 01day    9313 adult male 05day    9625 adult male 30day    11794 adult female 01day    30539 adult female 05day    37304 adult female 30day    35168 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020255    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020255 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020255 expression level Tissue   Expression Level Larval Central Nervous System    1739.075 Larval Midgut    806.9 Larval Hindgut    1183 Larval Malpighian Tubules    566.5 Larval Fat Body    884.6 Larval Salivary Gland    1686.6 Larval Trachea    1086.5 Larval Carcass    1411.65 Adult Head    563.2 Adult Eye    567.175 Adult Brain    619 Adult Thoracic-Abdominal Ganglion    804 Adult Crop    850.4 Adult Midgut    592 Adult Hindgut    515.2 Adult Malpighian Tubules    581.6 Adult Fat Body    982.3 Adult Salivary Gland    579.7 Adult Heart    693.525 Adult VirginFemale Spermatheca    984.4 Adult InseminatedFemale Spermatheca    1313.5 Adult Ovary    1639.8 Adult Testis    418 Adult Male Accessory Gland    716.5 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1739.075) Larval Midgut  (806.9) Larval Hindgut  (1183) Larval Malpighian Tubules  (566.5) Larval Fat Body  (884.6) Larval Salivary Gland  (1686.6) Larval Trachea  (1086.5) Larval Carcass  (1411.65) Adult Head  (563.2) Adult Eye  (567.175) Adult Brain  (619) Adult Thoracic-Abdominal Ganglion  (804) Adult Crop  (850.4) Adult Midgut  (592) Adult Hindgut  515.2 Adult Malpighian Tubules  (581.6) Adult Fat Body  (982.3) Adult Salivary Gland  (579.7) Adult Heart  (693.525) Adult VirginFemale Spermatheca  (984.4) Adult InseminatedFemale Spermatheca  (1313.5) Adult Ovary  (1639.8) Adult Testis    418 Adult Male Accessory Gland  (716.5) Adult Carcass  (552.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1739.075) Larval Midgut    806.9 Larval Hindgut  (1183) Larval Malpighian Tubules    566.5 Larval Fat Body    884.6 Larval Salivary Gland  (1686.6) Larval Trachea  (1086.5) Larval Carcass  (1411.65) Adult Head    563.2 Adult Eye    567.175 Adult Brain    619 Adult Thoracic-Abdominal Ganglion    804 Adult Crop    850.4 Adult Midgut    592 Adult Hindgut    515.2 Adult Malpighian Tubules    581.6 Adult Fat Body    982.3 Adult Salivary Gland    579.7 Adult Heart    693.525 Adult VirginFemale Spermatheca    984.4 Adult InseminatedFemale Spermatheca  (1313.5) Adult Ovary  (1639.8) Adult Testis    418 Adult Male Accessory Gland    716.5 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1739.075 Larval Midgut    806.9 Larval Hindgut    1183 Larval Malpighian Tubules    566.5 Larval Fat Body    884.6 Larval Salivary Gland    1686.6 Larval Trachea    1086.5 Larval Carcass    1411.65 Adult Head    563.2 Adult Eye    567.175 Adult Brain    619 Adult Thoracic-Abdominal Ganglion    804 Adult Crop    850.4 Adult Midgut    592 Adult Hindgut    515.2 Adult Malpighian Tubules    581.6 Adult Fat Body    982.3 Adult Salivary Gland    579.7 Adult Heart    693.525 Adult VirginFemale Spermatheca    984.4 Adult InseminatedFemale Spermatheca    1313.5 Adult Ovary    1639.8 Adult Testis    418 Adult Male Accessory Gland    716.5 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020255 expression level Tissue   Expression Level Larval Central Nervous System    1739.075 Larval Midgut    806.9 Larval Hindgut    1183 Larval Malpighian Tubules    566.5 Larval Fat Body    884.6 Larval Salivary Gland    1686.6 Larval Trachea    1086.5 Larval Carcass    1411.65 Adult Head    563.2 Adult Eye    567.175 Adult Brain    619 Adult Thoracic-Abdominal Ganglion    804 Adult Crop    850.4 Adult Midgut    592 Adult Hindgut    515.2 Adult Malpighian Tubules    581.6 Adult Fat Body    982.3 Adult Salivary Gland    579.7 Adult Heart    693.525 Adult VirginFemale Spermatheca    984.4 Adult InseminatedFemale Spermatheca    1313.5 Adult Ovary    1639.8 Adult Testis    418 Adult Male Accessory Gland    716.5 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1739.075) Larval Midgut  806.9 Larval Hindgut  (1183) Larval Malpighian Tubules  566.5 Larval Fat Body  (884.6) Larval Salivary Gland  (1686.6) Larval Trachea  (1086.5) Larval Carcass  (1411.65) Adult Head  563.2 Adult Eye  567.175 Adult Brain  619 Adult Thoracic-Abdominal Ganglion  804 Adult Crop  (850.4) Adult Midgut  592 Adult Hindgut  515.2 Adult Malpighian Tubules  581.6 Adult Fat Body  (982.3) Adult Salivary Gland  579.7 Adult Heart  693.525 Adult VirginFemale Spermatheca  (984.4) Adult InseminatedFemale Spermatheca  (1313.5) Adult Ovary  (1639.8) Adult Testis    418 Adult Male Accessory Gland  716.5 Adult Carcass  552.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1739.075) Larval Midgut    806.9 Larval Hindgut  1183 Larval Malpighian Tubules    566.5 Larval Fat Body    884.6 Larval Salivary Gland  1686.6 Larval Trachea  1086.5 Larval Carcass  1411.65 Adult Head    563.2 Adult Eye    567.175 Adult Brain    619 Adult Thoracic-Abdominal Ganglion    804 Adult Crop    850.4 Adult Midgut    592 Adult Hindgut    515.2 Adult Malpighian Tubules    581.6 Adult Fat Body    982.3 Adult Salivary Gland    579.7 Adult Heart    693.525 Adult VirginFemale Spermatheca    984.4 Adult InseminatedFemale Spermatheca  1313.5 Adult Ovary  1639.8 Adult Testis    418 Adult Male Accessory Gland    716.5 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1739.075 Larval Midgut    806.9 Larval Hindgut    1183 Larval Malpighian Tubules    566.5 Larval Fat Body    884.6 Larval Salivary Gland    1686.6 Larval Trachea    1086.5 Larval Carcass    1411.65 Adult Head    563.2 Adult Eye    567.175 Adult Brain    619 Adult Thoracic-Abdominal Ganglion    804 Adult Crop    850.4 Adult Midgut    592 Adult Hindgut    515.2 Adult Malpighian Tubules    581.6 Adult Fat Body    982.3 Adult Salivary Gland    579.7 Adult Heart    693.525 Adult VirginFemale Spermatheca    984.4 Adult InseminatedFemale Spermatheca    1313.5 Adult Ovary    1639.8 Adult Testis    418 Adult Male Accessory Gland    716.5 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    563.2   NA  Eye    567.175   NA  Brain    619   1739.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    804   NA  Crop    850.4   806.9  Midgut    592   1183  Hindgut    515.2   566.5  Malpighian Tubules    581.6   884.6  Fat Body    982.3   1686.6  Salivary Gland    579.7   NA  Heart    693.525   1086.5  Trachea    NA   NA  VirginFemale Spermatheca    984.4   NA  InseminatedFemale Spermatheca    1313.5   NA  Ovary    1639.8   NA  Testis    418   NA  Male Accessory Gland    716.5   1411.65  Carcass    552.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020255 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1404-RB;CG14991-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ran Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 ranGD8203 lethal | larval stage, with Scer\GAL4elav.PLu ranG19V.Q69L.Scer\UAS lethal | larval stage, with Scer\GAL4h-1J3 ranG19V.Q69L.Scer\UAS lethal | larval stage, with Scer\GAL4nub.PK ranG19V.Q69L.Scer\UAS lethal | pharate adult stage ranG0075 lethal | pharate adult stage, with Scer\GAL4pros.PMG ranG19V.Q69L.Scer\UAS semi-lethal | recessive ranG0075 viable ranEY05705 viable, with Scer\GAL4elav.PLu ranScer\UAS.cKa viable, with Scer\GAL4h-1J3 ranScer\UAS.cKa viable, with Scer\GAL4nub.PK ranScer\UAS.cKa viable, with Scer\GAL4pros.PMG ranScer\UAS.cKa viable, with Scer\GAL4unspecified ranG19V.Q69L.Scer\UAS ranScer\UAS.cKa Sterility Allele fertile ranEY05705 Other Phenotypes Allele visible, with Scer\GAL4sev.EP.M ranG19V.Q69L.Scer\UAS wild-type, with Scer\GAL4dpp.blk1 ranG19V.Q69L.Scer\UAS ranScer\UAS.cKa wild-type, with Scer\GAL4GMR.PF ranScer\UAS.cKa wild-type, with Scer\GAL4sev.EP.M ranScer\UAS.cKa Phenotype manifest in Allele cone cell, with Scer\GAL4GMR.PF ranG19V.Q69L.Scer\UAS ommatidium, with Scer\GAL4sev.EP.M ranG19V.Q69L.Scer\UAS photoreceptor cell, with Scer\GAL4GMR.PF ranG19V.Q69L.Scer\UAS photoreceptor cell, with Scer\GAL4sev.EP.M ranG19V.Q69L.Scer\UAS photoreceptor cell R7, with Scer\GAL4sev.EP.M ranG19V.Q69L.Scer\UAS pigment cell, with Scer\GAL4GMR.PF ranG19V.Q69L.Scer\UAS
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of ran Class Mutagen Stocks Known lesion ranEY05705 P-element activity 1 -- ranG0075 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ran Class Mutagen Stocks Known lesion ranGD8203 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ranJF01381 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ranKK108549 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes randsRNA.cRa in vitro construct - RNAi 0 Yes ranG19V.Q69L.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ranScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes ranβTub85D.PK in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC235 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8203} NA P{KK108549} NA P{TRiP.JF01381} NA P{UAS-ran.G19V.Q69L} NA P{UAS-ran.K} NA characterization construct P{βTub85D-ran.K} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}ranEY05705 NA insertion of enhancer trap P{lacW}ranG0075 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
GTP binding inferred from direct assay (assigned by UniProtKB) (Trieselmann and Wilde, 2002) protein binding inferred from physical interaction with tamo (assigned by UniProtKB) (Minakhina et al., 2003)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) cell cycle inferred from direct assay (assigned by UniProtKB) (Trieselmann and Wilde, 2002) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Minakhina et al., 2003) lipid particle inferred from direct assay (Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) nuclear microtubule inferred from direct assay (assigned by UniProtKB) (Trieselmann and Wilde, 2002)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity (Stivers et al., 1997, Jekely, 2003) inferred from sequence or structural similarity with mouse Ran (FlyBase, 1992-)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR002041 (FlyBase Curators et al., 2004-) intracellular protein transport inferred from electronic annotation with InterPro:IPR002041 (FlyBase Curators et al., 2004-) nucleocytoplasmic transport inferred from electronic annotation with InterPro:IPR002041 (FlyBase Curators et al., 2004-) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ran allele Gene References ranG19V.Q69L.Scer\UAS BacA\p35 (Koizumi et al., 2001) ranβTub85D.PK RanGap (Kusano et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68814 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020255 DroID - A comprehensive database of gene and protein interactions. • FBgn0020255 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44072
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20389 Dere\GG18876 Dgri\GH24573 Dmoj\GI15278 Dper\GL20255 Dpse\GA12719 Dsec\GM11261 Dsim\GD24539 Dvir\GJ16931 Dwil\GK17213 Dyak\ran
Curated drosophilid orthologs	Dpse\GA12719   Dyak\ran
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009287-PA Aedes aegypti (mosquito) AGAP007699-PC Anopheles gambiae (mosquito) XP_393761.1 Apis mellifera (honey bee) XP_001951291.1 Acyrthosiphon pisum (pea aphid) At5g20020.1 Arabidopsis thaliana (wall cress) 89133 Batrachochytrium dendrobatidis (chytrid fungus) 132195 Branchiostoma floridae (lancelet) 282949 Branchiostoma floridae (lancelet) BGIBMGA006751-PA Bombyx mori (silk worm) ENSBTAP00000017722 Bos taurus (bovine) CAL0005360 Candida albicans (a form of yeast) CN22671 Caenorhabditis brenneri (small nematode) CBP10814 Caenorhabditis briggsae (nematode) CE16194 Caenorhabditis elegans (worm) ENSCAFP00000009963 Canis familiaris (dog) CAGL0I00594g Candida glabrata (haploid yeast) Chro.70035 Cryptosporidium hominis (obligate parasite) ENSCINP00000008166 Ciona intestinalis (sea squirt) JA18889 Caenorhabditis japonica (nematode) CMT257C Cyanidioschyzon merolae (red alga) cn05296 Cryptococcus neoformans (yeast-like fungus) cgd7_220 Cryptosporidium parvum (protozoan parasite) CPIJ008595 Culex pipens (mosquito) 128522 Chlamidomonas reinhardtii (green alga) RP15054 Caenorhabditis remanei (nematode) ENSCSAVP00000010252 Ciona savignyi (sedentary tunicate) 21290 Capitella spl (polychaete worm) DDB0215409 Dictyostelium discoideum (amoeba) DEHA2F01980g Debaryomyces Hansenii (yeast) 305970 Daphnia pulex (daphnia) ENSDARP00000074060 Danio rerio (zebra fish) ENSECAP00000018078 Equus caballus (horse) XP_657523 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023469 Gymnopilus aculeatus (mushroom) ENSGALP00000038926 Gallus gallus (chicken) GL50803_15869 Giardia lamblia (flagellated protozoan) 185702 Hypsipyla robusta (cedar shoot borer) ENSP00000376176 Homo sapiens (human) ISCW023654-PA Ixodes scapularis (deer tick) KLLA0A04499g Kluyveromyces lactis (yeast) KLLA0C05126g Kluyveromyces lactis (yeast) 104069 Lottia gigantea (owl limpet) LmjF25.1420 Leishmania major (virus) 38949 Monocosta brevicollis (choanoflagellate) ENSMODP00000019467 Monodelphis domestica (gray opossum) ENSMMUP00000027540 Macaca mulatta (rhesus monkey) ENSMUSP00000031383 Mus musculus (house mouse) 170199 Nematostella vectensis (starlet anemone) XP_001607134.1 Nasonia vitripennis (wasp) ENSOANP00000010293 Ornithorynchus anatinus (platypus) ENSORLP00000004290 Oryzias latipes (japanese killifish) LOC_Os01g42530.1 Oryza sativa (asian rice) LOC_Os05g49890.1 Oryza sativa (asian rice) 20980 Ostreococcus tauri (green alga) PF11_0183 Plasmodium falciparum (protozoal parasite) PP29091 Pristionchus pacificus (nematode) 162510 Physcomitrella patens (moss) ENSPPYP00000005840 Pongo pygmaeus (orangutan) 51857 Phytophthora ramorum (sudden oak death pathogen) 108912 Phytophthora sojae (root rot pathogen) 561858 Populus trichocarpa (black cottonwood) 578173 Populus trichocarpa (black cottonwood) 578176 Populus trichocarpa (black cottonwood) 717966 Populus trichocarpa (black cottonwood) ENSPTRP00000009585 Pan troglodytes (chimpanzee) PVX_091515 Plasmodium vivax (protozoal parasite) ENSRNOP00000001247 Rattus norvegicus (norway rat) 149829 Sorghum bicolor (sorghum) YOR185C Saccharomyces cerevisiae (budding yeast) Smp_079430.2 Schistosoma mansoni (trematode parasite) SPBC1289.03c Schizosaccharomyces pombe (fission yeast) XP_786730.1 Strongylocentrotus purpuratus (purple sea urchin) 50649 Trichoplax adhaerens (metazoa) TA06865 Theileria annulata (apicomplexan parasite) XP_975893.1 Tribolium castaneum (red flour beetle) Tc00.1047053503539.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509455.80 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016119 Tetraodon nigroviridis (green spotted pufferfish) TP01_0757 Theileria parva (parasitic protozoan) 39470 Thalassiosira pseudonana (marine diatom) ENSTRUP00000035114 Takifugu rubripes (pufferfish Takifugu) 1.m01059 Tetrahymena thermophila (ciliate protozoa) 86498.m00509 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049065 Xenopus tropicalis (frog) YALI0F04730g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17956 NV14356 LH10986 ISCW023654 ISCW021828 FBgn0067934 FBgn0219212 FBgn0204110 FBgn0195873 FBgn0166206 JGI_V11_305970 FBgn0072765 FBgn0157850 FBgn0138027 FBgn0132029 FBgn0123675 FBgn0111083 FBgn0097396 CPIJ008595 BGIBMGA006751 ACYPI004024 GB13869 AGAP007699 AAEL009287 PHUM095420 GLEAN_12793
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	11800 w67c23 P{lacW}ranG0075/FM7c 31392 y1 v1; P{TRiP.JF01381}attP2 16670 y1 w67c23 P{EPgy2}ranEY05705
VDRC	v104417 P{KK108549}VIE-260B v24835 w1118; P{GD8203}v24835/CyO
Genomic Clones ( 1 )
	BACR26J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 304 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM14354 LD32416 LD40852
Other clones	DPiM_GM14354 yak-ad_ran
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03406 AT03953 AT05083 AT06835 AT10203 AT10604 AT18091 AT23407 AT25341 AT26534 AT28367 AT31261 GH06564 GH12910 GH15442 GM01009 GM02030 GM02241 GM02314 GM04532 GM04748 GM05471 GM07693 GM09615 GM10471 GM10589 GM10590 GM15154 GM16482 GM16977 GM19018 GM20671 GM23165 GM23842 GM29280 HL05568 LD01952 LD02219 LD02647 LD02808 LD03304 LD03512 LD03721 LD04269 LD04549 LD04926 LD05856 LD06345 LD06567 LD07628 LD07841 LD07907 LD07948 LD08160 LD08775 LD09039 LD10745 LD11364 LD11780 LD14881 LD18035 LD18247 LD19228 LD19318 LD20468 LD20553 LD23128 LD28110 LD28141 LD28859 LD29409 LD31908 LD31944 LD32170 LD32320 LD32586 LD32722 LD32771 LD33289 LD34434 LD34554 LD34556 LD35989 LD37253 LD37512 LD38162 LD38417 LD39144 LD40732 LD40746 LD40795 LD41971 LD42885 LD43141 LD43309 LD45059 LD45344 LD46001 LD48020 LD48061 LP01794 LP06433 LP06493 LP23965 RE06106 RE12481 RE15556 RE16546 RE21810 RE29178 RE31214 RE42747 RE46032 RE48182 RE48401 RE64103 RE66136 RE67974 RE74525 RE75173 RH06895 RH07824 RH11777 RH23408 RH23694 RH24247 RH28102 RH32745 RH37938 RH42931 RH45450 RH64715 SD02813 SD17153 SD17758 SD20784 SD22072 SD22854 SD26547
Other clones	18404 30207 32422 38500 58102 71406 145215 153355 164357 174841 292379 522995 523647 523723 524464 524665 524730 527124 542633 557696 571268 bs57a12 bs61a10 bs69d04 CK01.1D.G11 CK01.26A.C8 CK01.102A.B8 CK01.111B.H12 CK01.114B.D1 CK01.125A.E2 Dmel_dig_006558_0594_2670 Dmel_dig_011509_0589_2667 Dmel_dig_014003_0616_0864 Dmel_dig_016701_0634_2461 Dmel_neb_008032_0946_3501 Dmel_neb_010244_0826_2410 Dmel_neb_010907_0576_0610 Dmel_neb_012024_0835_3194 Dmel_neb_013505_0700_1768 Dmel_neb_014599_0697_3389 Dmel_neb_015455_0951_1198 EC24357 EC33488 EK000448 EK008226 EK086040 EK140946 EK180425 EK229501 EK268608 EK268634 EK276210 EN04029 EN04158 EN05437 EN05710 EN05825 EN07320 EN11015 EN12222 EN16457 FGC012H10 FGH118H05 FGM218B08 FGM224G01 FGM228C12 FGM233B07 FGM233D01 FGM301D02 FGM313D03 GH01582 LD01171 LD15410 LP16396 RC0-DA0001-120700-025-B07 RC0-DA0001-120700-027-F11 RE01537 RE02528 RE03270 RE03967 RE04148 RE08577 RE11904 RE12243 RE12540 RE13865 RE14677 RE14729 RE15205 RE15357 RE17175 RE17344 RE18504 RE18778 RE22605 RE23035 RE23315 RE23611 RE25251 RE28876 RE29537 RE30449 RE31021 RE31082 RE31335 RE31667 RE32146 RE32215 RE32517 RE33189 RE34409 RE37187 RE38347 RE38648 RE39057 RE39553 RE41523 RE42490 RE44283 RE46916 RE50182 RE52054 RE52763 RE54052 RE54946 RE54974 RE58005 RE59525 RE61165 RE62442 RE63753 RE64631 RE65193 RE65494 RE65848 RE65883 RE66002 RE66041 RE66750 RE67113 RE70010 RE70195 RE70751 RE71181 RE73086 RH05636 RH07816 RH09474 RH10175 RH15278 RH20201 RH24980 RH32918 RH45776 RH55283 UT01167 UT01329 UT01351 UUGC0425 UUGC0429
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020255 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44072
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ran CG1404 (Bayraktaroglu, 2000.8.7) Source for merge of: ran l(1)G0075 (Peter et al., 2002)
Additional comments	The ran-like gene may have been derived from the ran gene by retroposition. (Dai et al., 2006)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) dsRNA made from templates generated with primers directed against ran that is transfected into S2 treated with Listeria monocytogenes reveals ran to be involved in Listeria monocytogenes entry and vacuolar escape. (Cheng et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: Screen for genes required for late lineage CNS development. (Stivers et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143712 NM_167272 RefSeq (Proteins) • NP_651969 NP_727499 DDBJ / EMBL / GenBank • AA803818 AA951725 AAF30287 AAF48008 AAF60289 AAF60290 AAL28946 AAL48004 AAN09287 AAO39578 AF220950 AF233584 AF233585 AI519004 AJ426854 AW943135 AY061398 AY070533 BT003574 CL527823 Entrez Gene - A searchable database of RefSeq genes. • 44072 UniProtKB/Swiss-Prot • Q9VZ23
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ran GTPase (IPR002041) Small GTP-binding protein domain (IPR005225) Small GTPase superfamily (IPR001806)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68814 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020255 DroID - A comprehensive database of gene and protein interactions. • FBgn0020255 DRSC - Results from RNAi screens. • FBgn0020255 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020255 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1404-RB;CG14991-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020255 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44072 InParanoid A subset of ortholog calls from InParanoid. • AAEL009287-PA Aedes aegypti (mosquito) AGAP007699-PC Anopheles gambiae (mosquito) XP_393761.1 Apis mellifera (honey bee) XP_001951291.1 Acyrthosiphon pisum (pea aphid) At5g20020.1 Arabidopsis thaliana (wall cress) 89133 Batrachochytrium dendrobatidis (chytrid fungus) 132195 Branchiostoma floridae (lancelet) 282949 Branchiostoma floridae (lancelet) BGIBMGA006751-PA Bombyx mori (silk worm) ENSBTAP00000017722 Bos taurus (bovine) CAL0005360 Candida albicans (a form of yeast) CN22671 Caenorhabditis brenneri (small nematode) CBP10814 Caenorhabditis briggsae (nematode) CE16194 Caenorhabditis elegans (worm) ENSCAFP00000009963 Canis familiaris (dog) CAGL0I00594g Candida glabrata (haploid yeast) Chro.70035 Cryptosporidium hominis (obligate parasite) ENSCINP00000008166 Ciona intestinalis (sea squirt) JA18889 Caenorhabditis japonica (nematode) CMT257C Cyanidioschyzon merolae (red alga) cn05296 Cryptococcus neoformans (yeast-like fungus) cgd7_220 Cryptosporidium parvum (protozoan parasite) CPIJ008595 Culex pipens (mosquito) 128522 Chlamidomonas reinhardtii (green alga) RP15054 Caenorhabditis remanei (nematode) ENSCSAVP00000010252 Ciona savignyi (sedentary tunicate) 21290 Capitella spl (polychaete worm) DDB0215409 Dictyostelium discoideum (amoeba) DEHA2F01980g Debaryomyces Hansenii (yeast) 305970 Daphnia pulex (daphnia) ENSDARP00000074060 Danio rerio (zebra fish) ENSECAP00000018078 Equus caballus (horse) XP_657523 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023469 Gymnopilus aculeatus (mushroom) ENSGALP00000038926 Gallus gallus (chicken) GL50803_15869 Giardia lamblia (flagellated protozoan) 185702 Hypsipyla robusta (cedar shoot borer) ENSP00000376176 Homo sapiens (human) ISCW023654-PA Ixodes scapularis (deer tick) KLLA0A04499g Kluyveromyces lactis (yeast) KLLA0C05126g Kluyveromyces lactis (yeast) 104069 Lottia gigantea (owl limpet) LmjF25.1420 Leishmania major (virus) 38949 Monocosta brevicollis (choanoflagellate) ENSMODP00000019467 Monodelphis domestica (gray opossum) ENSMMUP00000027540 Macaca mulatta (rhesus monkey) ENSMUSP00000031383 Mus musculus (house mouse) 170199 Nematostella vectensis (starlet anemone) XP_001607134.1 Nasonia vitripennis (wasp) ENSOANP00000010293 Ornithorynchus anatinus (platypus) ENSORLP00000004290 Oryzias latipes (japanese killifish) LOC_Os01g42530.1 Oryza sativa (asian rice) LOC_Os05g49890.1 Oryza sativa (asian rice) 20980 Ostreococcus tauri (green alga) PF11_0183 Plasmodium falciparum (protozoal parasite) PP29091 Pristionchus pacificus (nematode) 162510 Physcomitrella patens (moss) ENSPPYP00000005840 Pongo pygmaeus (orangutan) 51857 Phytophthora ramorum (sudden oak death pathogen) 108912 Phytophthora sojae (root rot pathogen) 561858 Populus trichocarpa (black cottonwood) 578173 Populus trichocarpa (black cottonwood) 578176 Populus trichocarpa (black cottonwood) 717966 Populus trichocarpa (black cottonwood) ENSPTRP00000009585 Pan troglodytes (chimpanzee) PVX_091515 Plasmodium vivax (protozoal parasite) ENSRNOP00000001247 Rattus norvegicus (norway rat) 149829 Sorghum bicolor (sorghum) YOR185C Saccharomyces cerevisiae (budding yeast) Smp_079430.2 Schistosoma mansoni (trematode parasite) SPBC1289.03c Schizosaccharomyces pombe (fission yeast) XP_786730.1 Strongylocentrotus purpuratus (purple sea urchin) 50649 Trichoplax adhaerens (metazoa) TA06865 Theileria annulata (apicomplexan parasite) XP_975893.1 Tribolium castaneum (red flour beetle) Tc00.1047053503539.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509455.80 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016119 Tetraodon nigroviridis (green spotted pufferfish) TP01_0757 Theileria parva (parasitic protozoan) 39470 Thalassiosira pseudonana (marine diatom) ENSTRUP00000035114 Takifugu rubripes (pufferfish Takifugu) 1.m01059 Tetrahymena thermophila (ciliate protozoa) 86498.m00509 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049065 Xenopus tropicalis (frog) YALI0F04730g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/ran1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44072 modMine - Data generated by the modENCODE project. • FBgn0020255 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17956 NV14356 LH10986 ISCW023654 ISCW021828 FBgn0067934 FBgn0219212 FBgn0204110 FBgn0195873 FBgn0166206 JGI_V11_305970 FBgn0072765 FBgn0157850 FBgn0138027 FBgn0132029 FBgn0123675 FBgn0111083 FBgn0097396 CPIJ008595 BGIBMGA006751 ACYPI004024 GB13869 AGAP007699 AAEL009287 PHUM095420 GLEAN_12793
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	AAF30287 (Jekely, 2003) CG1404 (Peter et al., 2002, Ramet et al., 2002, Labourier et al., 2002, Cermelli et al., 2006, Dai et al., 2006, Minakhina et al., 2003, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2008, Cammarato et al., 2011) dran (Stivers et al., 1997) l(1)G0075 (Schaefer et al., 1999.6.15, Schaefer et al., 1999.3.29, ) Ran (Kategaya et al., 2009, Baeg et al., 2005, Timinszky et al., 2002, Jekely, 2003, Bernards, 2003, Orian et al., 2003, Hawley, 2001, Kusano et al., 2001, Kusano et al., 2001, Szabad et al., 2001, Minakhina et al., 2003, Silverman-Gavrila and Wilde, 2006, Cesario and McKim, 2008, McLean et al., 2008, Motiwale et al., 2008, Sepp et al., 2008, Hughes et al., 2008, Bono et al., 2010, Li et al., 2010) ran (Cermelli et al., 2006, Shigenobu et al., 2006, Somma et al., 2008, Babenko et al., 2009, Moussian et al., 2005, Popodi et al., 2010-, Bai et al., 2007, Zhou et al., 2008, Tracy et al., 2010) ran10A (Frasch, 2000.2.11)
Name Synonym	ran (Somma et al., 2008, Cammarato et al., 2011) Ran GTPase (Sepp et al., 2008)
Secondary FlyBase IDs
	FBgn0026685 FBgn0030273
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 7 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation. [FBrf0216492] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Bono et al., 2010, Mol. Cell 37(2): 211--222 Nuclear Import Mechanism of the EJC Component Mago-Y14 Revealed by Structural Studies of Importin 13. [FBrf0209868] Li et al., 2010, J. Biol. Chem. 285(26): 19705--19709 Regulation of mTORC1 by the Rab and Arf GTPases. [FBrf0211071] Tracy et al., 2010, Genetics 184(4): 1067--1076 Convergently recruited nuclear transport retrogenes are male biased in expression and evolving under positive selection in Drosophila. [FBrf0210734] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...