FB2025_02 , released April 17, 2025
Gene: Dmel\Ppa
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General Information
Symbol
Dmel\Ppa
Species
D. melanogaster
Name
Partner of paired
Annotation Symbol
CG9952
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020257
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
59A1-59A2
Sequence location
Recombination map
2-101
RefSeq locus
NT_033778 REGION:22684955..22688987
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN002547163
(GO Reference Genome Project, 2011-)
inferred from sequence model
(FlyBase Curators, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of SCF ubiquitin ligase complex
inferred from biological aspect of ancestor with PANTHER:PTN002547163
(GO Reference Genome Project, 2011-)
inferred from sequence model
(FlyBase Curators, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
F BOX AND LEUCINE-RICH REPEAT PROTEINS -
F box and Leucine-rich repeat (FBXL) proteins are F box proteins which contain leucine-rich repeats. F box proteins are the variable substrate adapters for Skp, Cullin, F-box (SCF) E3 ubiquitin ligase complexes. (Adapted from FBrf0225076).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Ppa for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KF28)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ppa-RA
FBtr0071924
NM_079088
3463
538
Ppa-RB
FBtr0330249
NM_001274209
3463
562
Ppa-RC
FBtr0343014
NM_001299814
4033
538
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ppa-PA
FBpp0071835
58.4
538
8.22
Q9W214
NP_523812
AAF46886
Ppa-PB
FBpp0303282
60.9
562
8.13
A0A0B4KF28
NP_001261138
AGB93669
Ppa-PC
FBpp0309766
58.4
538
8.22
Q9W214
NP_001286743
AHN56538
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

538 aa isoforms: Ppa-PA, Ppa-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ppa using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.93

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
clypeo-labral anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic cycle 10 -- embryonic cycle 13
organism | uniform

Comment: not maternally deposited

(Raj et al., 2000)
embryonic stage 5 -- 8
organism | pair rule expression pattern
(Raj et al., 2000)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
clypeo-labral anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 12
organism | segmentally repeated
(Raj et al., 2000)
embryonic stage 11 -- 12
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ppa in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ppa
Transgenic constructs containing regulatory region of Ppa
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
chemical sensitive, with Scer\GAL4da.G32
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
mesonotum, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (26)
Hsap\FBXL14
14 of 14
Yes
Yes
1  
Hsap\FBXL13
3 of 14
No
No
Hsap\FBXL16
3 of 14
No
No
Hsap\AMN1
2 of 14
No
Yes
Hsap\FBXL3
2 of 14
No
No
Hsap\FBXL4
2 of 14
No
No
Hsap\FBXL5
2 of 14
No
Yes
Hsap\FBXL6
2 of 14
No
No
Hsap\FBXL7
2 of 14
No
No
Hsap\FBXL12
2 of 14
No
No
1  
Hsap\FBXL17
2 of 14
No
No
Hsap\FBXL22
2 of 14
No
Yes
Hsap\KDM2A
2 of 14
No
No
2  
Hsap\KDM2B
2 of 14
No
No
Hsap\DMAC2
1 of 14
No
No
Hsap\DMAC2L
1 of 14
No
No
Hsap\FBXL2
1 of 14
No
No
Hsap\FBXL9P
1 of 14
No
No
1  
Hsap\FBXL15
1 of 14
No
No
1  
Hsap\FBXL19
1 of 14
No
No
Hsap\FBXL20
1 of 14
No
No
1  
Hsap\FBXL21P
1 of 14
No
No
Hsap\FBXO33
1 of 14
No
No
Hsap\FBXO39
1 of 14
No
No
Hsap\NLRC5
1 of 14
No
Yes
Hsap\SKP2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (28)
Rnor\Fbxl13
3 of 14
Yes
No
Rnor\Fbxl16
3 of 14
Yes
No
Rnor\Fbxl4
2 of 14
No
No
Rnor\Fbxl5
2 of 14
No
Yes
Rnor\Fbxl6
2 of 14
No
No
Rnor\Fbxl12
2 of 14
No
No
Rnor\Fbxl14
2 of 14
No
Yes
Rnor\Fbxl15
2 of 14
No
No
Rnor\Fbxl17
2 of 14
No
No
Rnor\Fbxl21
2 of 14
No
No
Rnor\Fbxl22
2 of 14
No
Yes
Rnor\Fbxo39
2 of 14
No
Yes
Rnor\Kdm2a
2 of 14
No
No
Rnor\Kdm2b
2 of 14
No
No
Rnor\Lrrc29
2 of 14
No
No
Rnor\Amn1
1 of 14
No
No
Rnor\Dmac2l
1 of 14
No
No
Rnor\Dmac2
1 of 14
No
No
Rnor\Fbxl2
1 of 14
No
No
Rnor\Fbxl3
1 of 14
No
No
Rnor\Fbxl7
1 of 14
No
No
Rnor\Fbxl8
1 of 14
No
No
Rnor\Fbxl19
1 of 14
No
No
Rnor\Fbxl20
1 of 14
No
No
Rnor\Fbxo33
1 of 14
No
No
Rnor\Lrrcc1
1 of 14
No
No
Rnor\RGD1560784
1 of 14
No
Yes
Rnor\Skp2
1 of 14
No
No
Mus musculus (laboratory mouse) (26)
Mmus\Fbxl14
14 of 14
Yes
Yes
Mmus\Fbxl16
3 of 14
No
No
Mmus\Fbxl3
2 of 14
No
No
Mmus\Fbxl4
2 of 14
No
No
Mmus\Fbxl5
2 of 14
No
Yes
Mmus\Fbxl6
2 of 14
No
No
Mmus\Fbxl7
2 of 14
No
No
Mmus\Fbxl12
2 of 14
No
No
Mmus\Fbxl13
2 of 14
No
No
Mmus\Fbxl15
2 of 14
No
No
Mmus\Fbxl17
2 of 14
No
No
Mmus\Fbxl19
2 of 14
No
No
Mmus\Fbxl21
2 of 14
No
No
Mmus\Fbxl22
2 of 14
No
Yes
Mmus\Fbxo39
2 of 14
No
Yes
Mmus\Kdm2a
2 of 14
No
No
Mmus\Kdm2b
2 of 14
No
No
Mmus\Lrrc29
2 of 14
No
No
Mmus\Amn1
1 of 14
No
No
Mmus\B630019K06Rik
1 of 14
No
Yes
Mmus\Dmac2l
1 of 14
No
No
Mmus\Dmac2
1 of 14
No
No
Mmus\Fbxl2
1 of 14
No
No
Mmus\Fbxl20
1 of 14
No
No
Mmus\Fbxo33
1 of 14
No
No
Mmus\Skp2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\fbxl14
8 of 13
Yes
Yes
Xtro\fbxl5
2 of 13
No
Yes
Xtro\fbxl16
2 of 13
No
No
Xtro\ssbp1
2 of 13
No
No
Xtro\aldh3b2
1 of 13
No
No
Xtro\b4gat1
1 of 13
No
No
Xtro\fbxl3
1 of 13
No
No
Xtro\fbxl4
1 of 13
No
No
Xtro\fbxl12
1 of 13
No
No
Xtro\fbxl13
1 of 13
No
Yes
Xtro\fbxl15
1 of 13
No
No
Xtro\fbxl21p
1 of 13
No
No
Xtro\fbxo33
1 of 13
No
No
Xtro\kdm2a
1 of 13
No
No
Xtro\lingo1
1 of 13
No
No
Danio rerio (Zebrafish) (32)
Drer\fbxl14a
14 of 14
Yes
Yes
Drer\fbxl14b
14 of 14
Yes
Yes
Drer\fbxl13
3 of 14
No
No
Drer\si:ch73-173p19.1
3 of 14
No
Yes
Drer\fbxl3l
2 of 14
No
No
Drer\fbxl4
2 of 14
No
No
Drer\fbxl5
2 of 14
No
Yes
Drer\fbxl6
2 of 14
No
No
Drer\fbxl7
2 of 14
No
No
Drer\fbxl15
2 of 14
No
No
Drer\fbxl16
2 of 14
No
No
Drer\fbxl17
2 of 14
No
No
Drer\kdm2ab
2 of 14
No
No
Drer\lrrc29
2 of 14
No
No
Drer\si:dkey-192l18.9
2 of 14
No
No
Drer\amn1
1 of 14
No
No
Drer\dmac2l
1 of 14
No
No
Drer\fbxl2
1 of 14
No
No
Drer\fbxl3a
1 of 14
No
No
Drer\fbxl3b
1 of 14
No
No
Drer\fbxl8
1 of 14
No
No
Drer\fbxl20
1 of 14
No
No
Drer\fbxl22
1 of 14
No
No
Drer\kdm2aa
1 of 14
No
No
Drer\kdm2ba
1 of 14
No
No
Drer\kdm2bb
1 of 14
No
No
Drer\LOC100536129
1 of 14
No
No
Drer\rxfp2b
1 of 14
No
No
Drer\si:ch73-236c18.7
1 of 14
No
Yes
Drer\si:dkey-59l11.10
1 of 14
No
Yes
Drer\skp2
1 of 14
No
No
Drer\zgc:158376
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (26)
Cele\T01E8.1
3 of 14
Yes
Yes
Cele\B0393.3
2 of 14
No
No
Cele\gadr-4
2 of 14
No
Yes
Cele\skpt-1
2 of 14
No
No
Cele\Y53G8AR.8
2 of 14
No
No
Cele\B0564.6
1 of 14
No
No
Cele\B0564.9
1 of 14
No
No
Cele\C05C8.1
1 of 14
No
No
Cele\C48D1.1
1 of 14
No
Yes
Cele\EEED8.10
1 of 14
No
No
Cele\F44E5.2
1 of 14
No
No
Cele\F53G2.1
1 of 14
No
No
Cele\fbxl-1
1 of 14
No
No
Cele\gadr-3
1 of 14
No
No
Cele\gadr-5
1 of 14
No
Yes
Cele\gadr-6
1 of 14
No
No
Cele\H04D03.4
1 of 14
No
Yes
Cele\H24K24.2
1 of 14
No
No
Cele\K02A6.3
1 of 14
No
No
Cele\K05C4.9
1 of 14
No
No
Cele\R02D5.8
1 of 14
No
No
Cele\T28B4.1
1 of 14
No
No
Cele\Y9C9A.13
1 of 14
No
No
Cele\Y55F3C.9
1 of 14
No
Yes
Cele\Y71A12B.15
1 of 14
No
No
Cele\zeel-1
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (25)
Agam\AgaP_AGAP010289
12 of 12
Yes
Yes
Agam\AgaP_AGAP012123
3 of 12
No
No
Agam\AgaP_AGAP001895
2 of 12
No
No
Agam\AgaP_AGAP003285
2 of 12
No
No
Agam\AgaP_AGAP006408
2 of 12
No
No
Agam\AgaP_AGAP006431
2 of 12
No
No
Agam\AgaP_AGAP009335
2 of 12
No
No
Agam\AgaP_AGAP010607
2 of 12
No
Yes
Agam\AgaP_AGAP011930
2 of 12
No
No
Agam\AgaP_AGAP012769
2 of 12
No
No
Agam\AgaP_AGAP000471
1 of 12
No
No
Agam\AgaP_AGAP003661
1 of 12
No
No
Agam\AgaP_AGAP004167
1 of 12
No
Yes
Agam\AgaP_AGAP004478
1 of 12
No
No
Agam\AgaP_AGAP004683
1 of 12
No
No
Agam\AgaP_AGAP005273
1 of 12
No
No
Agam\AgaP_AGAP005297
1 of 12
No
No
Agam\AgaP_AGAP005622
1 of 12
No
No
Agam\AgaP_AGAP007061
1 of 12
No
No
Agam\AgaP_AGAP007807
1 of 12
No
No
Agam\AgaP_AGAP009775
1 of 12
No
No
Agam\AgaP_AGAP011911
1 of 12
No
No
Agam\AgaP_AGAP011928
1 of 12
No
No
Agam\AgaP_AGAP011929
1 of 12
No
No
Agam\AgaP_AGAP011947
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (62)
Atha\AT1G15740
4 of 13
Yes
Yes
Atha\AFB2
3 of 13
No
Yes
Atha\AFB3
3 of 13
No
Yes
Atha\AFB4
3 of 13
No
Yes
Atha\AFB5
3 of 13
No
Yes
Atha\AT1G55590
3 of 13
No
Yes
Atha\AT2G17020
3 of 13
No
Yes
Atha\AT4G15475
3 of 13
No
No
Atha\AT5G01720
3 of 13
No
Yes
Atha\AT5G23340
3 of 13
No
No
Atha\AT5G27920
3 of 13
No
No
Atha\AT5G67140
3 of 13
No
Yes
Atha\EBF1
3 of 13
No
No
Atha\EBF2
3 of 13
No
Yes
Atha\GRH1
3 of 13
No
Yes
Atha\SLOMO
3 of 13
No
Yes
Atha\TIR1
3 of 13
No
Yes
Atha\AT1G80570
2 of 13
No
No
Atha\AT1G80630
2 of 13
No
No
Atha\AT2G06040
2 of 13
No
No
Atha\AT2G36370
2 of 13
No
Yes
Atha\AT3G07550
2 of 13
No
No
Atha\AT3G48880
2 of 13
No
Yes
Atha\AT3G58530
2 of 13
No
No
Atha\AT4G03630
2 of 13
No
Yes
Atha\AT4G03635
2 of 13
No
Yes
Atha\AT4G05460
2 of 13
No
Yes
Atha\AT4G05470
2 of 13
No
Yes
Atha\AT4G05475
2 of 13
No
Yes
Atha\AT4G05490
2 of 13
No
No
Atha\AT4G05497
2 of 13
No
Yes
Atha\AT4G11580
2 of 13
No
Yes
Atha\AT4G30640
2 of 13
No
Yes
Atha\AT5G07670
2 of 13
No
No
Atha\AT5G21900
2 of 13
No
No
Atha\AT5G40470
2 of 13
No
No
Atha\AT5G51370
2 of 13
No
No
Atha\AT5G51380
2 of 13
No
No
Atha\AT5G52480
2 of 13
No
Yes
Atha\COI1
2 of 13
No
Yes
Atha\FBW2
2 of 13
No
Yes
Atha\SKIP1
2 of 13
No
Yes
Atha\SKIP2
2 of 13
No
No
Atha\SKP2A
2 of 13
No
Yes
Atha\SKP2B
2 of 13
No
Yes
Atha\SNC1
2 of 13
No
Yes
Atha\VFB1
2 of 13
No
No
Atha\VFB2
2 of 13
No
No
Atha\VFB3
2 of 13
No
No
Atha\ARABIDILLO-1
1 of 13
No
No
Atha\ARABIDILLO-2
1 of 13
No
No
Atha\AT1G16940
1 of 13
No
Yes
Atha\AT1G47695
1 of 13
No
Yes
Atha\AT1G50980
1 of 13
No
Yes
Atha\AT3G44630
1 of 13
No
Yes
Atha\AT4G05500
1 of 13
No
Yes
Atha\AT4G23840
1 of 13
No
Yes
Atha\AT4G26980
1 of 13
No
Yes
Atha\AT4G36140
1 of 13
No
No
Atha\FBL17
1 of 13
No
Yes
Atha\MAX2
1 of 13
No
Yes
Atha\RPP1
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\GRR1
3 of 13
Yes
No
Scer\RAD7
3 of 13
Yes
Yes
Scer\AMN1
2 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\pof2
3 of 12
Yes
No
Spom\rhp7
2 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ppa. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (23)
CG32085
6 of 13
CG8272
4 of 13
CG9003
4 of 13
CG14891
4 of 13
CG15056
4 of 13
Fbxl7
4 of 13
CG9316
3 of 13
CG12402
3 of 13
Fbxl4
3 of 13
FipoQ
3 of 13
jet
3 of 13
CG5003
2 of 13
Fbl6
2 of 13
Kdm2
2 of 13
Skp2
2 of 13
CG4911
1 of 13
CG10731
1 of 13
CG11044
1 of 13
CG14102
1 of 13
CG32221
1 of 13
CG43064
1 of 13
CG44006
1 of 13
Lgr4
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    PpaJF01315
    exacerbates  Machado-Joseph disease
    modeled by Hsap\ATXN3fl.SCA3.UAS
    (Ashraf et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FBXL14; F-box and leucine rich repeat protein 14
    14 of 14
    609081
         
        FBXL13; F-box and leucine rich repeat protein 13
        3 of 14
        609080
            FBXL16; F-box and leucine rich repeat protein 16
            3 of 14
            609082
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                RNA-protein
                Physical Interaction
                Assay
                References
                Ppa - stau
                anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
                (Laver et al., 2013)
                protein-protein
                Physical Interaction
                Assay
                References
                Ppa - cid
                two hybrid, pull down, western blot, autoradiography
                (Moreno-Moreno et al., 2011)
                Summary of Genetic Interactions
                Interaction Browsers
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2R
                Recombination map
                2-101
                Cytogenetic map
                59A1-59A2
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                59A1-59A2
                Limits computationally determined from genome sequence between P{EP}EP718EP718 and P{EP}ppaEP698&P{EP}EP2184
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                58F7-59A1
                (Raj, 1999.9.17)
                Experimentally Determined Recombination Data
                Location

                2-101

                (FlyBase, 2016)

                2-105.5

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (13)
                Genomic Clones (17)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (120)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                  Other Comments

                  Identification: Yeast interaction trap for proteins that interact with prd gene product.

                  (Raj et al., 1997)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: ppa CG9952

                  (FlyBase, 1996-)
                  Additional comments

                  The ppa gene may have been derived from the CG12402 gene by retroposition.

                  (Pan and Zhang, 2009)

                  Source for merge of ppa CG9952 was sequence comparison ( date:001003 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Ppa ppa

                  (FlyBase, 2009-)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (8)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 45 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (66)