exoribonuclease that degrades decapped mRNA - directly interacts with Decapping protein 1 to couple mRNA decapping to 5' exonucleolytic degradation - required for degradation of mRNAs targeted by NMD and RNAi - regulates polycomb silencing - regulates insulin-like peptide and the neuropeptide-like precursor Nplp2 mRNA levels - affects apoptosis and regulates expression of and - regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in wing imaginal discs
Gene model reviewed during 5.45
Gene model reviewed during 5.56
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pcm using the Feature Mapper tool.
pcm transcripts are abundantly expressed in 0-4 and 4-8hr embryos and in adult males and females. pcm transcripts are first detected by in situ hybridization in stage 3 egg chambers in both nurse cells and the oocyte. By stage 10, expression is mainly in nurse cells with very little expression in the oocyte. In embryos, transcripts are ubiquitously distributed and are particularly abundant in the germ band and in head structures.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pcm in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: pcm CG3291
Changes in expression profiles associated with the unfolded protein response have been analyzed in S2 cells following treatment with dsRNA made from templates generated with primers directed against this gene.
dsRNA has been made from templates generated with primers directed against this gene.