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Gene Dmel\mre11

General Information
Symbol	Dmel\mre11	Species	D. melanogaster
Name	meiotic recombination 11	Annotation symbol	CG16928
Feature type	protein_coding_gene	FlyBase ID	FBgn0020270
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32E2-32E2	Sequence location	2L:11,282,090..11,284,335 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene meiotic recombination 11 is referred to in FlyBase by the symbol Dmel\mre11 (CG16928, FBgn0020270). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endonuclease activity; exonuclease activity. There is experimental evidence that it is involved in the biological process: G2 DNA damage checkpoint; response to DNA damage stimulus; telomere maintenance; chromosome organization; telomere capping. 14 alleles are reported. The phenotype of these alleles is annotated with: chromosome, telomeric region. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA repair protein Mre11; Metallophosphoesterase domain; Mre11, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637151_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mre11. Gene sequence location is 2L:11282090..11284335.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32E2-32E2   Limits computationally determined from genome sequence between P{PZ}l(2)0400804008&P{PZ}cmet04431 and P{PZ}salm03602
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32F1-32F2     (Brodsky, 1999.3.2) 32F-32F   (determined by in situ hybridisation)   (Flores, 1997.4.18)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mre11 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mre11-RA FBtr0080213  NM_078823   2013   620
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mre11-PA   FBpp0079802   69.3   620   5.81     NP_523547   AAF53093
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA repair protein Mre11 (IPR003701) Metallophosphoesterase domain (IPR004843) Mre11, DNA-binding (IPR007281)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246197   AA264398   AA264980   AA440659   AA539320   AA820331   AA942402   AE014134 AAF53093   AF132144 AAD33591   AI389561   AI389955   AI513019   AI513643   AI543536   BG640821   BI239505   BI240375   BI242033   BI591969   BI592983   BI593028   BI608046   BI610981   BI612645   BI617063   BI631452   CO315909   EC066434   EL879413
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9XYZ4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    324.95 Larval Midgut    141.5 Larval Hindgut    208.7 Larval Malpighian Tubules    214.9 Larval Fat Body    78.1 Larval Salivary Gland    149.9 Larval Trachea    309.225 Larval Carcass    133.175 Adult Head    122.2 Adult Eye    159.2 Adult Brain    160.6 Adult Thoracic-Abdominal Ganglion    236.1 Adult Crop    167.7 Adult Midgut    121.9 Adult Hindgut    133.8 Adult Malpighian Tubules    299.2 Adult Fat Body    103.7 Adult Salivary Gland    219.9 Adult Heart    199.425 Adult VirginFemale Spermatheca    205 Adult InseminatedFemale Spermatheca    280.8 Adult Ovary    309 Adult Testis    38.5 Adult Male Accessory Gland    222.3 Adult Carcass    124.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    122.2   NA  Eye    159.2   NA  Brain    160.6   324.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    236.1   NA  Crop    167.7   141.5  Midgut    121.9   208.7  Hindgut    133.8   214.9  Malpighian Tubules    299.2   78.1  Fat Body    103.7   149.9  Salivary Gland    219.9   NA  Heart    199.425   309.225  Trachea    NA   NA  VirginFemale Spermatheca    205   NA  InseminatedFemale Spermatheca    280.8   NA  Ovary    309   NA  Testis    38.5   NA  Male Accessory Gland    222.3   133.175  Carcass    124.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    20 ovary, mated 4-day female    18 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    46 embryo 04-06hr    36 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day    36 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (49) embryo 02-04hr  (46) embryo 04-06hr  (36) embryo 06-08hr  (34) embryo 08-10hr  (32) embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day  (36) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    46 embryo 04-06hr    36 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day    36 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    46 embryo 04-06hr    36 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day    36 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    46 embryo 04-06hr    36 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day    36 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (49) embryo 02-04hr  (46) embryo 04-06hr  (36) embryo 06-08hr  (34) embryo 08-10hr  32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day  (36) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    46 embryo 04-06hr    36 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day    36 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    46 embryo 04-06hr    36 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    19 embryo 12-14hr    16 embryo 14-16hr    17 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    14 embryo 22-24hr    17 larva L1    17 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    21 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    22 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    24 adult female 05day    36 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    24 embryonic 1182-4H    33 embryonic GM2    35 embryonic Kc167    66 embryonic S1    39 embryonic S3    29 leg disc CME L1    24 wing disc CME-W2    55 wing disc ML-DmD8    25 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    25 ovary fGS/OSS    35 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (28) Schneider line 2 Sg4    24 embryonic 1182-4H  (33) embryonic GM2  (35) embryonic Kc167  (66) embryonic S1  (39) embryonic S3  (29) leg disc CME L1    24 wing disc CME-W2  (55) wing disc ML-DmD8    25 wing disc ML-DmD9  (35) wing disc ML-DmD16-c3    21 wing disc ML-DmD21  (30) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11  (42) antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1  (31) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2    25 ovary fGS/OSS  (35) ovary OSC  (31) ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    24 embryonic 1182-4H    33 embryonic GM2    35 embryonic Kc167    66 embryonic S1    39 embryonic S3    29 leg disc CME L1    24 wing disc CME-W2    55 wing disc ML-DmD8    25 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    25 ovary fGS/OSS    35 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    24 embryonic 1182-4H    33 embryonic GM2    35 embryonic Kc167    66 embryonic S1    39 embryonic S3    29 leg disc CME L1    24 wing disc CME-W2    55 wing disc ML-DmD8    25 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    25 ovary fGS/OSS    35 ovary OSC    31 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    24 embryonic 1182-4H    33 embryonic GM2    35 embryonic Kc167    66 embryonic S1    39 embryonic S3    29 leg disc CME L1    24 wing disc CME-W2    55 wing disc ML-DmD8    25 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    25 ovary fGS/OSS    35 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  28 Schneider line 2 Sg4    24 embryonic 1182-4H  (33) embryonic GM2  (35) embryonic Kc167  (66) embryonic S1  (39) embryonic S3  29 leg disc CME L1    24 wing disc CME-W2  (55) wing disc ML-DmD8    25 wing disc ML-DmD9  (35) wing disc ML-DmD16-c3    21 wing disc ML-DmD21  30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11  (42) antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1  31 CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2    25 ovary fGS/OSS  (35) ovary OSC  31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    24 embryonic 1182-4H    33 embryonic GM2    35 embryonic Kc167    66 embryonic S1    39 embryonic S3    29 leg disc CME L1    24 wing disc CME-W2    55 wing disc ML-DmD8    25 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    25 ovary fGS/OSS    35 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    24 embryonic 1182-4H    33 embryonic GM2    35 embryonic Kc167    66 embryonic S1    39 embryonic S3    29 leg disc CME L1    24 wing disc CME-W2    55 wing disc ML-DmD8    25 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    30 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    25 ovary fGS/OSS    35 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD08638 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020270 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16928-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect mre1158S lethal | pupal stage mre11unspecified lethal | pupal stage | recessive mre11Δ35K1 viable, with Scer\GAL4pnr-MD237 mre11GD4185 Sterility Allele female sterile mre1158S male fertile mre1158S Other Phenotypes Allele mitotic cell cycle defective mre1158S mre11Δ35K1 radiation sensitive mre11Δ35K1 Phenotype manifest in Allele chromosome, telomeric region mre11Δ35K1 chromosome & neuroblast | third instar larval stage 2 mre11unspecified mitosis & nuclear chromosome mre11Δ35K1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of mre11 Class Mutagen Stocks Known lesion mre11G6145 P-element activity 1 -- mre11Δ35K1 recombination ends-out gene targeting 1 Yes mre11+.5' recombination SCEI endonuclease FLPase gene targeting by homologous recombination 0 -- mre11armGFP gene targeting by homologous recombination 0 Yes mre11H230Y.3' recombination SCEI endonuclease FLPase gene targeting by homologous recombination 0 Yes mre11unspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mre11 Class Mutagen Stocks Known lesion mre11GD4185 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mre11HMS01947 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mre11+tCa in vitro construct - genomic fragment 0 Yes mre11+tCb in vitro construct - genomic fragment 0 Yes mre1158S hypomorphic allele - genetic evidence 0 -- mre11NIG.16928R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes mre11Scer\SceI.RS.cGa in vitro construct 0 Yes mre11Scer\SceI.RS in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6028 (Ryder, 2004.4.26) Df(2L)k07716-V.1 (Ciapponi et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4185} NA P{NIG.16928R} NA P{TRiP.HMS01947} NA characterization construct P{FRT(mre11.Scer\SceI.RS.armGFP)} NA P{FRT(whs.mre11Scer\SceI.RS)} NA P{mre11.H230Y} NA P{mre11+tCa} NA P{mre11+tCb} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}mre11G6145 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromosome organization inferred from mutant phenotype (Bi et al., 2004, Ciapponi et al., 2004) G2 DNA damage checkpoint inferred from mutant phenotype (Bi et al., 2005) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) telomere capping inferred from direct assay (Gao et al., 2009) telomere maintenance inferred from mutant phenotype (Bi et al., 2004, Ciapponi et al., 2004, Bi et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
endonuclease activity inferred from sequence or structural similarity with Saccharomyces MRE11 (FlyBase, 1992-) non-traceable author statement (Brodsky, 1999.3.2) exonuclease activity inferred from sequence or structural similarity with Saccharomyces MRE11 (FlyBase, 1992-) non-traceable author statement (Brodsky, 1999.3.2) manganese ion binding inferred from electronic annotation with InterPro:IPR007281 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
double-strand break repair inferred from sequence or structural similarity with Saccharomyces MRE11 (FlyBase, 1992-) nucleotide-excision repair non-traceable author statement (Brodsky, 1999.3.2)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR007281 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
mre11 - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mre11 - GABPI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mre11 allele Gene References mre11Δ35K1 tefu (Bi et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60622 DroID - A comprehensive database of gene and protein interactions. • FBgn0020270 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34565 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9XYZ4
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64QTKG Dipteran inclusive ortholog search EOG6SXNMR Insect inclusive ortholog search EOG6DJHRK Arthropod inclusive ortholog search EOG6JM64S Metazoa inclusive ortholog search EOG6K9Q5C
Orthologs in Drosophila Species (EOG64QTKG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mre11     Drosophila simulans   Dsim\GD23775 Y   Drosophila sechellia   Dsec\GM19007 Y   Drosophila erecta   Dere\GG23718 Y   Drosophila yakuba   Dyak\GE18523 Y   Drosophila ananassae   Dana\GF14771 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14221 Y   Drosophila persimilis   Dper\GL19555 Y   Drosophila willistoni   Dwil\GK21058 Y   Drosophila virilis   Dvir\GJ13289 Y   Drosophila mojavensis   Dmoj\GI20705 Y   Drosophila grimshawi   Dgri\GH13392 Y
Orthologs in non-Drosophila Dipterans (EOG6SXNMR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010595   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000034   Anopheles gambiae Malaria mosquito  Agam\AGAP006797   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004537
Orthologs in non-Dipteran Insects (EOG6DJHRK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49582   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013556   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16703   Atta cephalotes Leafcutter ant  Acep\ACEP11146   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18197   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13081   Linepithema humile Argentine ant  Lhum\LH17547   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10616   Solenopsis invicta Red fire ant  Sinv\SINV14930   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005628   Bombyx mori Silkmoth  Bmor\BGIBMGA001084   Pediculus humanus Human body louse  Phum\PHUM168400   Tribolium castaneum Red flour beetle  Tcas\mre11
Orthologs in non-Insect Arthropods (EOG6JM64S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_188962
Orthologs in non-Arthropod Metazoa (EOG6K9Q5C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mre-11   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014629gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028109gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018262gn   Danio rerio Zebrafish  Drer\mre11a   Xenopus tropicalis Western clawed frog  Xtro\mre11a   Gallus gallus Domestic chicken  Ggal\MRE11A   Mus musculus House mouse  Mmus\Mre11a   Rattus norvegicus Norway rat  Rnor\Mre11a   Homo sapiens Human  Hsap\MRE11A
Human Orthologs (1)
Gene OMIM HGNC Hsap\MRE11A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23775 Drosophila sechellia Dsec\GM19007 Drosophila erecta Dere\GG23718 Drosophila yakuba Dyak\GE18523 Drosophila ananassae Dana\GF14771 Drosophila pseudoobscura pseudoobscura Dpse\GA14221 Drosophila persimilis Dper\GL19555 Drosophila willistoni Dwil\GK21058 Drosophila virilis Dvir\GJ13289 Drosophila mojavensis Dmoj\GI20705 Drosophila grimshawi Dgri\GH13392
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	39028 y1 v1; P{TRiP.HMS01947}attP40 26917 y1 w*; P{EP}mre11G6145/CyO 43639 mre11Δ35K1/T(2;3)TSTL, CyO: TM6B, Tb+
VDRC	v30474 w1118; P{GD4185}v30474 v30476 w1118; P{GD4185}v30476
Genomic Clones ( 1 )
	BACR43K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD08638
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH20771 GH21278 LD06151 LD08140 LD15514 LD19016 LD23892 LD26586 LD45233 LD45849 RE36001 RE37210 RE39249 RH09544 RH10835 RH10892 RH12176 RH17033 RH41580 RH47273 RH61027 SD10328 SD11976
Other clones	159921 EK262961 IP09393
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020270 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34565
Antibody Information
	polyclonal (Gao et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	mre11 is required for the maintenance of normal telomeres. (Bi et al., 2004) mre11 mutants show a high level of spontaneous telomere fusions in larval neuroblasts. (Bi et al., 2004) Mutants show high levels of spontaneous telomere fusion and chromosome breakage in dividing cells. (Ciapponi et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078823 RefSeq (Proteins) • NP_523547 DDBJ / EMBL / GenBank • AA264980 AAD33591 AAF53093 AF132144 AFH03655 Entrez Gene - A searchable database of RefSeq genes. • 34565 UniProtKB/TrEMBL • Q9XYZ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA repair protein Mre11 (IPR003701) Metallophosphoesterase domain (IPR004843) Mre11, DNA-binding (IPR007281) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD08638
Linkouts
	BioGRID - A database of protein and genetic interactions • 60622 DroID - A comprehensive database of gene and protein interactions. • FBgn0020270 DRSC - Results from RNAi screens. • FBgn0020270 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020270 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16928-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020270 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34565 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34565 modMine - Data generated by the modENCODE project. • FBgn0020270 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9XYZ4
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	16928 (Ravi et al., 2009) CG16928 (Ni et al., 2010.12.1) MRE11 (Ahmad, 2004, Flores, 1997.4.18, Flores and Engels, 1997, Cenci et al., 2005) Mre11 (Villeneuve and Hillers, 2001, Pawlowski and Cande, 2005, Hochwagen, 2006, Gao et al., 2008, Brodsky et al., 2004, Raffa et al., 2011, Gao et al., 2009, Gao et al., 2009) mre11 (Oikemus et al., 2007, Ciapponi et al., 2006, Bi et al., 2005, Akdemir et al., 2007, Oikemus et al., 2006, Kurzhals et al., 2011, Huang et al., 2008, Rong, 2008, Anderson et al., 2009, Raffa et al., 2009, Musarò et al., 2008, Rehwinkel et al., 2005, Gao et al., 2010, Morciano et al., 2009, Gong et al., 2005, Kondo and Perrimon, 2011, Zhang et al., 2011, Reis et al., 2011, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	meiotic recombination 11 (Morciano et al., 2009)
Secondary FlyBase IDs
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Kurzhals et al., 2011, PLoS Genet. 7(6): e1002103 Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss. [FBrf0216299] Raffa et al., 2011, Nucleus 2(5): 383--391 Terminin: A protein complex that mediates epigenetic maintenance of Drosophila telomeres. [FBrf0216520] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...