FB2019_06, released Dec 19, 2019

Gene: Dmel\mst

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General Information
Symbol
Dmel\mst
Species
D. melanogaster
Name
misato
Annotation Symbol
CG1424
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020272
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
misato (mst) encodes a conserved protein that acts as a co-factor of the TCP-1 tubulin chaperone complex. It is required for mitotic spindle assembly and viability and for tubulin polymerization and stability. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
LB20, l(1)LB20
Key Links
Genomic Location
Cytogenetic map
20A1-20A1
Sequence location
X:21,388,977..21,391,533 [+]
Recombination map
1-66
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the misato family. (O01939)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Summary (Interactive Fly)
co-factor of the Tubulin Chaperone Protein-1 (TCP-1) complex - plays an essential role in the Tubulin-folding processes required for proper assembly of spindle microtubules - depletion of Misato in the visceral muscle is a model of the pathogenic mechanism for visceral myopathy - mutations in inhibit kinetochore-driven microtubule growth
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\mst or the JBrowse view of Dmel\mst for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mst-RA
FBtr0077211
NM_078711
1893
574
mst-RB
FBtr0346380
NM_001298589
2443
574
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
mst-PA
FBpp0076907
64.8
574
4.67
NP_523435
AAF50817
mst-PB
FBpp0312074
64.8
574
4.67
NP_001285518
AHN59988
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

574 aa isoforms: mst-PA, mst-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
574 (aa)
(Maleszka et al., 1998, Miklos et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mst using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (5 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
mitotic sister chromatid segregation
inferred from mutant phenotype
(Miklos et al., 1997)
mitotic spindle assembly
inferred from mutant phenotype
(Mottier-Pavie et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
mitochondrial genome maintenance
inferred from biological aspect of ancestor with PANTHER:PTN000333441
(assigned by GO_Central )
(Gaudet et al., 2011)
mitochondrion distribution
inferred from biological aspect of ancestor with PANTHER:PTN000333441
(assigned by GO_Central )
(Gaudet et al., 2011)
mitotic sister chromatid segregation
inferred from biological aspect of ancestor with PANTHER:PTN000333441
(assigned by GO_Central )
(Gaudet et al., 2011)
mitotic spindle assembly
inferred from biological aspect of ancestor with PANTHER:PTN000333441
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Mottier-Pavie et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000333441
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
imaginal disc
(Maleszka et al., 1998)
embryonic/larval fat body
(Maleszka et al., 1998)
adult stage
adult brain
(Maleszka et al., 1998)
adult stage | female
(Miklos et al., 1997)
adult stage & oogenesis
ovary
(Maleszka et al., 1998)
embryonic stage -- adult stage
(Maleszka et al., 1998)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
pharate adult stage
brain
(Maleszka et al., 1998)
Additional Descriptive Data
mst transcripts are detected in embryos, larvae, pupae, and adults on northern blots and in ovaries, larval fat body, imaginal discs, and late pupal and adult brain by RT-PCR.
(Maleszka et al., 1998)
The mst transcript is relatively rare. The highest levels are found in the female germ line.
(Miklos et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Mottier-Pavie et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mst in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mst
Transgenic constructs containing regulatory region of mst
Deletions and Duplications ( 157 )
Disrupted in
Df(1)2/19B
(Maleszka et al., 1996, Miklos and de Couet, 1990, Perrimon et al., 1989)
Df(1)14-11
(Munoz, 2003.12.10)
Df(1)16-1-88
(Munoz, 2004.1.5)
Df(1)16-3-22
(Miklos et al., 1987)
Df(1)16-3-95
(Munoz, 2004.1.5)
Df(1)16-3-129
(Munoz, 2004.1.5)
Df(1)16-3-139
(Munoz, 2004.1.5)
Df(1)16-3-160
(Munoz, 2004.1.5)
Df(1)17-59
(Schalet and Lefevre, 1973)
Df(1)17-241
(Munoz, 2003.12.10)
Df(1)17-244
(Munoz, 2004.1.5)
Df(1)17-257
(Maleszka et al., 1996, Russell et al., 1992, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)17-322
(Munoz, 2004.1.5)
Df(1)17-351
(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)17-412
(Munoz, 2004.1.5)
Df(1)17-489
(Perrimon et al., 1989, Miklos et al., 1987)
Df(1)18-36
(Munoz, 2004.1.5)
Df(1)19-2
(Munoz, 2004.1.5)
Df(1)19-18
(Munoz, 2004.1.5, Munoz, 2003.12.10)
Df(1)26B
(Perrimon et al., 1989)
Df(1)156
(Paradi et al., 1983)
Df(1)217
(Paradi et al., 1983)
Df(1)218
(Paradi et al., 1983)
Df(1)A53
(Perrimon et al., 1989)
Df(1)B12
(Prud'homme et al., 1995, Lifschytz and Yakobovitz, 1978)
Df(1)C74
(Miklos and de Couet, 1990, Perrimon et al., 1989)
Df(1)D43L1
(Kramers et al., 1991, Perrimon et al., 1989, Kramers et al., 1983, Paradi et al., 1983)
Df(1)DCB1-35b
(Prud'homme et al., 1995, Perrimon et al., 1989)
Df(1)GA33
(Perrimon et al., 1989)
Df(1)GA37
(Perrimon et al., 1989)
Df(1)GA40
(Perrimon et al., 1989)
Df(1)GA104
(Maleszka et al., 1996, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)GE263
(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)HM45
(Kramers et al., 1983)
Df(1)HM49
(Kramers et al., 1983)
Df(1)HM50
(Kramers et al., 1983)
Df(1)JA117
(Miklos et al., 1997, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)JC77
(Miklos et al., 1997, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)LB6
(Prud'homme et al., 1995, Perrimon et al., 1989)
Df(1)LB7
(Perrimon et al., 1989)
Df(1)LB23
(Perrimon et al., 1989)
Df(1)mal3
(Kramers et al., 1991, Kramers et al., 1983)
Df(1)mal6
(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983)
Df(1)mal12
(Paradi et al., 1983)
Df(1)n17-8
(Munoz, 2004.1.5)
Df(1)N77
(Perrimon et al., 1989)
Df(1)Q539
(Miklos et al., 1997, Prud'homme et al., 1995, Kramers et al., 1991, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Kramers et al., 1983, Paradi et al., 1983, Schalet and Lefevre, 1973)
Df(1)S54
(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)su(f)7085
(Lifschytz and Yakobovitz, 1978)
Df(1)su(f)9122
(Lifschytz and Yakobovitz, 1978)
Df(1)T100
(Paradi et al., 1983)
Df(1)T101
(Paradi et al., 1983)
Df(1)T103
(Paradi et al., 1983)
Df(1)T106
(Paradi et al., 1983)
Df(1)T107
(Paradi et al., 1983)
Df(1)T113
(Paradi et al., 1983)
Df(1)T114
(Paradi et al., 1983)
Df(1)T122
(Paradi et al., 1983)
Df(1)T123
(Paradi et al., 1983)
Df(1)T124
(Paradi et al., 1983)
Df(1)T130
(Paradi et al., 1983)
Df(1)T138
(Paradi et al., 1983)
Not disrupted in
Df(1)16-2-13
(Prud'homme et al., 1995, Miklos et al., 1987)
Df(1)16-3-35
(Kramers et al., 1991, Perrimon et al., 1989, Miklos et al., 1987, Paradi et al., 1983)
Df(1)16-3-53
(Munoz, 2004.1.5)
Df(1)16-129
(Maleszka et al., 1996, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)
Df(1)17-87
(Rahman and Lindsley, 1980)
Df(1)17-137
(Kramers et al., 1991, Schalet and Lefevre, 1973)
Df(1)17-148
(Prud'homme et al., 1995)
Df(1)17-228
(Munoz, 2004.1.5)
Df(1)17-369
(Munoz, 2004.1.5)
Df(1)17-456
(Munoz, 2004.1.5)
Df(1)18-80
(Munoz, 2004.1.5, Schalet and Lefevre, 1973)
Df(1)120
(Paradi et al., 1983)
Df(1)127
(Paradi et al., 1983)
Df(1)136
(Paradi et al., 1983)
Df(1)167
(Paradi et al., 1983)
Df(1)208
(Paradi et al., 1983)
Df(1)216
(Paradi et al., 1983)
Df(1)228
(Paradi et al., 1983)
Df(1)A118
(Kramers et al., 1991, Perrimon et al., 1989, Miklos et al., 1987, Kramers et al., 1983, Paradi et al., 1983, Lifschytz and Yakobovitz, 1978)
Df(1)A209
(Rahman and Lindsley, 1980)
Df(1)B57
(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Lifschytz and Yakobovitz, 1978)
Df(1)DCB1-35c
(Prud'homme et al., 1995, Miklos et al., 1987)
Df(1)EA113
(Miklos et al., 1987)
Df(1)flam-l9
(Prud'homme et al., 1995)
Df(1)GA22
(Miklos et al., 1987)
Df(1)GA42
(Rahman and Lindsley, 1980)
Df(1)GA90
(Rahman and Lindsley, 1980)
Df(1)GA131
(Miklos et al., 1987)
Df(1)HC279
(Perrimon et al., 1989)
Df(1)HF359
(Miklos et al., 1987)
Df(1)HM5
(Kramers et al., 1983)
Df(1)HM8
(Kramers et al., 1983)
Df(1)HM44
(Miklos et al., 1997, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Miklos et al., 1986, Kramers et al., 1983)
Df(1)HM47
(Kramers et al., 1983)
Df(1)HM418
(Kramers et al., 1983)
Df(1)HM422
(Kramers et al., 1983)
Df(1)HM444
(Kramers et al., 1983)
Df(1)HM455
(Kramers et al., 1983)
Df(1)JA21
(Miklos et al., 1987)
Df(1)JC4
(Miklos and de Couet, 1990, Miklos et al., 1987)
Df(1)l2
(Prud'homme et al., 1995)
Df(1)l3
(Prud'homme et al., 1995)
Df(1)l4
(Prud'homme et al., 1995)
Df(1)l5
(Prud'homme et al., 1995)
Df(1)l6
(Prud'homme et al., 1995)
Df(1)l7
(Prud'homme et al., 1995)
Df(1)l8
(Prud'homme et al., 1995)
Df(1)l10
(Prud'homme et al., 1995)
Df(1)l11
(Prud'homme et al., 1995)
Df(1)l12
(Prud'homme et al., 1995)
Df(1)l13
(Prud'homme et al., 1995)
Df(1)l14
(Prud'homme et al., 1995)
Df(1)l15
(Prud'homme et al., 1995)
Df(1)l16
(Prud'homme et al., 1995)
Df(1)M31
(Lifschytz and Yakobovitz, 1978)
Df(1)M158
(Lifschytz and Yakobovitz, 1978)
Df(1)M171
(Lifschytz and Yakobovitz, 1978)
Df(1)M176
(Lifschytz and Yakobovitz, 1978)
Df(1)mal8
(Kramers et al., 1991, Paradi et al., 1983)
Df(1)mal10
(Perrimon et al., 1989, Paradi et al., 1983)
Df(1)mal12
(Rahman and Lindsley, 1980)
Df(1)mal17
(Perrimon et al., 1989)
Df(1)R7
(Prud'homme et al., 1995)
Df(1)R20
(Prud'homme et al., 1995)
Df(1)R21
(Prud'homme et al., 1995)
Df(1)R25
(Rahman and Lindsley, 1980)
Df(1)R44
(Prud'homme et al., 1995, Rahman and Lindsley, 1980)
Df(1)R46
(Prud'homme et al., 1995)
Df(1)run1112
(Perrimon et al., 1989)
Df(1)Sp20A-F
(Schalet, 1986)
Df(1)su(f)4B
(Kramers et al., 1991, Kramers et al., 1983)
Df(1)su(f)724
(Prud'homme et al., 1995, Lifschytz and Yakobovitz, 1978)
Df(1)su(f)733
(Lifschytz and Yakobovitz, 1978)
Df(1)su(f)754
(Lifschytz and Yakobovitz, 1978)
Df(1)su(f)795
(Lifschytz and Yakobovitz, 1978)
Df(1)su(f)7009
(Lifschytz and Yakobovitz, 1978)
Df(1)T2-14A
(Perrimon et al., 1989, Miklos et al., 1987)
Df(1)T105
(Paradi et al., 1983)
Df(1)T110
(Paradi et al., 1983)
Df(1)T136
(Paradi et al., 1983)
Df(1)T137
(Paradi et al., 1983)
Df(1)X-1
(Rahman and Lindsley, 1980)
Df(1)y-X15
(Kramers et al., 1991, Rahman and Lindsley, 1980)
Dp(1;Y)y+mal126
(Lifschytz and Yakobovitz, 1978)
Not duplicated in
Dp(1;Y)BS
(Prud'homme et al., 1995, Kramers et al., 1991)
Dp(1;Y)y+mal118
(Prud'homme et al., 1995)
Dp(1;Y)y+mal126
(Kramers et al., 1991, Miklos and de Couet, 1990, Kramers et al., 1983, Schalet and Lefevre, 1973)
Dp(1;Y)y+malN152
(Prud'homme et al., 1995)
Duplicated in
Dp(1;f)mini2
(Perrimon et al., 1989)
Dp(1;f)mini7
(Prud'homme et al., 1995)
Dp(1;f)mini77
(Miklos and de Couet, 1990, Perrimon et al., 1989)
Dp(1;f)mini-ring
(Perrimon et al., 1989)
Dp(1;Y)B101
(Perrimon et al., 1989)
Dp(1;Y)y+mal102
(Prud'homme et al., 1995, Perrimon et al., 1989)
Dp(1;Y)y+mal106
(Prud'homme et al., 1995, Miklos and de Couet, 1990)
Dp(1;Y)y+mal171
(Perrimon et al., 1989)
Dp(1;Y)y+mal+
(Prud'homme et al., 1995, Lefevre, 1981)
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | germline clone
lethal, with Scer\GAL4da.PU
lethal, with Scer\GAL4Tub.PU
lethal | recessive
lethal - all die before end of larval stage | recessive
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
feeding behavior defective | adult stage, with Scer\GAL4Act5C.PI
feeding behavior defective | adult stage, with Scer\GAL4how-24B
feeding behavior defective | adult stage, with Scer\GAL4Mef2.PU
feeding behavior defective | adult stage, with Scer\GAL4tey-5053A
increased cell death | adult stage, with Scer\GAL4Mef2.PU
mitotic cell cycle defective
mitotic cell cycle defective | larval stage
short lived, with Scer\GAL4how-24B
short lived, with Scer\GAL4Mef2.PU
size defective, with Scer\GAL4how-24B
size defective, with Scer\GAL4Mef2.PU, Scer\GAL80nSyb.PS
size defective, with Scer\GAL4tey-5053A
size defective | adult stage, with Scer\GAL4Mef2.PU
size defective | adult stage | progressive, with Scer\GAL4Mef2.PU
some die during larval stage | recessive
wild-type
Phenotype manifest in
Allele
adult abdomen, with Scer\GAL4Mef2.PU
adult midgut, with Scer\GAL4how-24B
adult midgut, with Scer\GAL4Mef2.PU
adult midgut, with Scer\GAL4Mef2.PU, Scer\GAL80nSyb.PS
adult midgut, with Scer\GAL4tey-5053A
adult midgut longitudinal muscle, with Scer\GAL4tey-5053A
adult midgut muscle, with Scer\GAL4how-24B
adult midgut muscle, with Scer\GAL4Mef2.PU
filamentous actin | adult stage, with Scer\GAL4Mef2.PU
mitochondrion | adult stage, with Scer\GAL4Mef2.PU
mitotic spindle
neuroblast | larval stage
sarcomere | adult stage, with Scer\GAL4Mef2.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MSTO1
15 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Msto1
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Msto1
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\msto1
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\msto1
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (1)
Atha\AT4G37190
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\DML1
9 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\dml1
8 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905GT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\mst
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008242
Drosophila simulans
Dsim\GD17537
Drosophila sechellia
Dsec\GM23085
Drosophila erecta
Dere\GG19729
Drosophila yakuba
Dyak\GE17927
Drosophila ananassae
Dana\GF20926
Drosophila pseudoobscura pseudoobscura
Dpse\GA12852
Drosophila persimilis
Dper\GL16019
Drosophila willistoni
Dwil\GK25434
Drosophila virilis
Dvir\GJ16019
Drosophila mojavensis
Dmoj\GI21660
Drosophila grimshawi
Dgri\GH24680
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504JT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019003
Glossina morsitans
Tsetse fly
Gmor\GMOY003790
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10187
Mayetiola destructor
Hessian fly
Mdes\Mdes005213
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008947
Anopheles darlingi
American malaria mosquito
Adar\ADAC003063
Anopheles gambiae
Malaria mosquito
Agam\AGAP002778
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012456
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04DG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000446
Danaus plexippus
Monarch butterfly
Dple\DPOGS203266-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015363
Apis florea
Little honeybee
Aflo\4020252708
Apis mellifera
Western honey bee
Amel\LOC551622
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22222
Bombus terrestris
Buff-tailed bumblebee
Bter\15212273
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00299c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004352
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05413
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15425
Pediculus humanus
Human body louse
Phum\PHUM371400
Rhodnius prolixus
Kissing bug
Rpro\RPRC002663
Cimex lectularius
Bed bug
Clec\CLEC009021
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI28797
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001528
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03305
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04A6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012010
Ixodes scapularis
Black-legged tick
Isca\ISCW015167
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62795.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300608
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0FFX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Msto1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008620
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000019794
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
mstUAS.ORF
ameliorates  congenital myopathy
modeled by mstJF03280
(Min et al., 2017)
mstJF03280
model of  congenital myopathy
is ameliorated by mstUAS.ORF
(Min et al., 2017)
is ameliorated by Act79BUASp.GFP
(Min et al., 2017)
is ameliorated by BacA\p35UAS.cHa
(Min et al., 2017)
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MSTO1; misato mitochondrial distribution and morphology regulator 1
15 of 15
617619
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    mst - CCT1
    anti tag coimmunoprecipitation, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot
    (Palumbo et al., 2015)
    mst - CCT2
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CCT3
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CCT4
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CCT5
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CCT6
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CCT7
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CCT8
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - CG5721
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - PDCD-5
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - Pfdn1
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - Pfdn2
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - Pfdn4
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - Pfdn5
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - Pfdn6
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - STUB1
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - Smyd4-4
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - mgr
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    mst - viaf
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Palumbo et al., 2015)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    mst
    suppressible
    Act79B
    (Min et al., 2017)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-66
    Cytogenetic map
    20A1-20A1
    Sequence location
    X:21,388,977..21,391,533 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    20A1-20A1
    Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    1-66
    (FlyBase, 2016)
    1-66.0
    (Comeron et al., 2012)
    1-
    (Miklos, 1997.8.4)
    Left of (cM)
    (Schalet, 1972)
    Right of (cM)
    (Schalet, 1972)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (10)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (6)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Mottier-Pavie et al., 2011)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: mst CG1424
      (Li, 1999.11)
      Source for database merge of
      Additional comments
      Other Comments
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      (Kiger et al., 2003)
      Origin and Etymology
      Discoverer
      Etymology
      Misato means 'beautiful dawn'.
      (Miklos et al., 1997)
      Identification
      External Crossreferences and Linkouts ( 32 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (10)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (64)