Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lush using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\lush in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
lush mediates both avoidance of concentrated alcohols and attraction to 11-cis vaccenyl acetate pheromone.
lush is specifically required for 11-cis vaccenyl acetate sensitivity of T1 neurons.
In contrast to FBrf0104760, which suggested that lush can modify the perception of ethanol at high concentrations (which would require some specific binding of ethanol to lush protein), no specific binding of ethanol to lush protein has been detected in studies in FBrf0174630. Instead, in FBrf0174630, it has been shown that lush protein binds some phthalates.
The gene is named "lush" after the increased affinity of mutant flies for alcohol-rich environments.