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Gene Dmel\dve

General Information
Symbol	Dmel\dve	Species	D. melanogaster
Name	defective proventriculus	Annotation symbol	CG5799
Feature type	protein_coding_gene	FlyBase ID	FBgn0020307
Gene Model Status	Current	Stock availability	18 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58D2-58D2	Sequence location	2R:18,131,468..18,173,974 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene defective proventriculus is referred to in FlyBase by the symbol Dmel\dve (CG5799, FBgn0020307). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; AT DNA binding. There is experimental evidence that it is involved in the biological process: copper ion import; negative regulation of transcription from RNA polymerase II promoter; imaginal disc-derived wing morphogenesis; midgut development; imaginal disc-derived leg joint morphogenesis. 38 alleles are reported. The phenotypes of these alleles are annotated with: larva; embryonic/larval midgut; proventriculus inner layer; eye disc; wing disc; cuprophilic cell; midgut; proventriculus outer layer; wing; proventriculus. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeodomain; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, adult male accessory gland. Gene sequence location is 2R:18131468..18173974.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58D2-58D2   Limits computationally determined from genome sequence between P{PZ}ari-207768 and P{lacW}l(2)k09801k09801
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58D1-58D2     (Nakagoshi, 1998.1.10) 58D1-58D2     (Fuss, 1998.9.28) 58D1-58D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 58D1-58D2   58D1--3   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dve for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dve-RA FBtr0071775  NM_057894   4903   1024 dve-RB FBtr0071776  NM_057893   3469   780
Additional Transcript Data & Comments
Reported size (kB)	5.0, 1.7 (northern blot) (Fuss and Hoch, 1998) 4.9 (longest cDNA) (Nakagoshi et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dve-PA   FBpp0071689   112.0   1024   6.64     NP_477242   AAF46827 dve-PB   FBpp0089292   85.8   780   6.40     NP_477241   AAM68216
Additional Polypeptide Data & Comments
Reported size (kDa)	1021, 245 (aa) (Fuss and Hoch, 1998) 1019 (aa) (Nakagoshi et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain (IPR001356) Homeodomain-like (IPR009057)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46827   AE013599 AAM68216   AB010299 BAA32660   AC004252   AJ011671 CAA09729   AJ011672 CAA09730   AQ034163   AY128459 AAM75052   BH146146   BH146147   BI164075   BI236478   BI369965   BI568815   BI569487   BI569601   BI589622   BI589756   BT025086   BZ665777   CL526218   CO179487   CO186411   CO269634   CO315942   CO319827   CZ474185   CZ475651   CZ476383   EC051962   EC052472   EC054471   EC055515   EC056581   EC058504   EC066047   EC089346   EC089945   EC090042   EC229223   EC239630   EC243139   EL874518   G00411   GH748338   GH748838   GH751135   GH754057   GH755772   GH777966   GH778284   GH784562   GH784672   GH787333   GH791325   GH791358   GH802522   GH805452   GH810307   GH819104   GH826949   GH832932   GH835457   GH849534   GH852331   GH857852   GH863465   GH864660   GH864770   GH868479   GH869347   GH881347   GH883287   GH884727   GH893607   GH893994   GH895198   GH911414   GH915599   GH916964   GH917043   GH925134   GH928999   GH930685   GH938923   GH939083
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MLT6 Q9W268 O77289 Q8MQP8 O76143 Q9TYH1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435440 2R:18,134,411..18,136,065 evidence=Reporter construct (in vivo) (Busser et al., 2012, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 17   anterior midgut primordium | restricted   (Fuss and Hoch, 1998) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) dorsal sensory complex primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) proventriculus primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 12   posterior midgut primordium | anterior   (Fuss and Hoch, 1998) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic midgut chamber   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 16   proventriculus outer layer   (Fuss and Hoch, 1998) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17     (Fuss and Hoch, 1998) Comment:reference states 0-18 hr AEL embryonic stage 9   mesectoderm | restricted   (Fuss and Hoch, 1998) embryonic stage 12   embryonic/larval pharynx | vicinity of   (Fuss and Hoch, 1998) embryonic stage 13   ventral nerve cord | restricted   (Fuss and Hoch, 1998) embryonic brain | restricted   (Fuss and Hoch, 1998) embryonic stage 13 -- 17   embryonic/larval midgut | restricted   (Fuss and Hoch, 1998)
Additional Descriptive Data
	The 1.7 kb dve transcript is expressed at low levels in embryos. A probe that detects both the 1.7 and 5.0 kb dve transcripts, and a probe that detects only the 5.0 kb transcript give the same in situ hybridization pattern, indicating that the expression pattern of the 1.7 kb and 5.0 kb transcripts overlap. (Fuss and Hoch, 1998) The 5.0 kb dve transcript is expressed at high levels in embryos. Starting in stage 9 embryos, dve transcript is detected in the anterior midgut primordium in a region that will give rise to the proventriculus endoderm. This expression persists and in later stages is confined to the outer endodermal wall of the developing proventriculus. At stage 12, expression is detected at the anterior tip of the posterior midgut primordium, in endodermal cells in the midgut/hindgut boundary, and in cells at the base of the pharynx. At stage 13, expression is detected in the anterior, central and posterior portions of the midgut. In stage 14 embryos, the central expression domain expands, and by stage 16 covers the second and third midgut lobes. Additional expression is detected in mesectodermal cells in stage 9, neural cells in the ventral nerve cord and in the brain lobes at stage 13, and the tip cells of the Malpighian tubules. (Fuss and Hoch, 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   stomodeum   (Nakagoshi et al., 1998) embryonic stage 11 -- 17   anterior midgut primordium | restricted   (Nakagoshi et al., 1998) embryonic stage 12 -- 17   embryonic foregut   (Fuss et al., 2004) Comment:endodermal cells embryonic stage 13 -- 17   mid embryonic/larval midgut | restricted   (Nakagoshi et al., 1998) posterior embryonic/larval midgut | restricted   (Nakagoshi et al., 1998) embryonic stage 14 -- 15   keyhole structure | posterior   (Fuss et al., 2004) embryonic stage 16   proventriculus outer layer   (Nakagoshi et al., 1998) embryonic/larval midgut cell | precursor   (Nakagoshi et al., 1998) embryonic stage 17   embryonic proventriculus outer layer   (Fuss et al., 2004) third instar larval stage   wing disc | restricted   (Nakagoshi et al., 2002, Kolzer et al., 2003)
Additional Descriptive Data
	dve protein is expressed in the entodermal cells of the developing embryonic foregut. Expression stops sharply at the ectodermal/endodermal boundary. (Fuss et al., 2004) In early to midthird instar larvae dve protein is detected in the developing wing pouch. Expression initially overlaps that of wg. In mid to late third instar larvae dve protein is excluded from the dorsal/ventral boundary and is expressed in a pattern complementary to wg protein. In late third instar larvae the distal expression of dve is decreased but the proximal expression remains. (Nakagoshi et al., 2002) Protein expression is first detected in the wing disc at the time that wg expression resolves into a peripheral ring and a stripe at the dorsal-ventral boundary. dve expression is observed in a disc-like domain within the ring of wg expression and is excluded from most of the dorsal-ventral boundary soon after expression is initiated. (Kolzer et al., 2003) dve protein is first detected in the invaginated stomodeum of stage 10 embryos. dve and wg protein expression in the stomodeum overlap at first, but subsequently separate into adjacent but non-overlapping regions. dve protein is expressed in the anterior-most region of the midgut, in the region that will become the outer layer of the proventriculus at stage 16. Starting at stage 13, dve protein is also detected in the central and posterior-most regions of the midgut; the central region, where the anterior and posterior midgut primordia are fused, will become the second and third gut lobes at stage 16. All four types of specialized embryonic/larval midgut cells including copper and interstitial cell precursors in this region express dve at stage 16; in larval stages, dve expression is repressed in copper cells. (Nakagoshi et al., 1998)
Marker for
	embryonic proventriculus outer layer
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Nakagoshi et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    8 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    12 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    16 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    11 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    5 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    4 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • IP14647 RE03646 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020307 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5799-RB;CG5799-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dve Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dve01738 dvek06515 lethal, with Scer\GAL4pnr-MD237 dveGD1425 lethal (with Df(2R)X58-5) dve01738 lethal (with dve01738) dveBG02382 lethal (with dveBG02382) dve01738 lethal | larval stage | recessive dve01738 dve01829 dve05084 dve06432 lethal | recessive dve01493 dve01704 dve01738 dvek06515 dveND369 partially lethal - majority die dveE181 viable dveEY10348 dveSH255 Sterility Allele fertile dveEY10348 Other Phenotypes Allele visible dve01738 visible, with Scer\GAL4ey.PU dveScer\UAS.cUa visible, with Scer\GAL4vg.PM dveScer\UAS.cNa visible | pharate adult stage, with Scer\GAL4bi-md653 dve5.0.Scer\UAS visible | recessive | somatic clone dve01738 Phenotype manifest in Allele cuprophilic cell dve01738 dveE38 cuprophilic cell, with Scer\GAL448Y dveScer\UAS.cNa cuprophilic cell, with Scer\GAL4hs.PB dveScer\UAS.cNa cuprophilic cell, with Scer\GAL4NP3012 dveScer\UAS.cNa cuprophilic cell, with Scer\GAL4NP3157 dveB.Scer\UAS.T:Zzzz\FLAG cuprophilic cell | male limited | heat sensitive, with Scer\GAL4NP3123 dveGD1425 embryonic/larval midgut, with Scer\GAL448Y dveB.Scer\UAS.T:Zzzz\FLAG embryonic/larval proventriculus | embryonic stage dve01738 eye disc, with Scer\GAL4ey.PU dveScer\UAS.cUa joint | dorsal | pharate adult stage, with Scer\GAL4bi-md653 dve5.0.Scer\UAS joint | ectopic | somatic clone dve01738 larva, with Scer\GAL448Y dveB.Scer\UAS.T:Zzzz\FLAG midgut dve01738 midgut, with Scer\GAL448Y dveScer\UAS.cNa midgut, with Scer\GAL4NP3012 dveScer\UAS.cNa midgut, with Scer\GAL4NP3157 dveB.Scer\UAS.T:Zzzz\FLAG midgut, with Scer\GAL4NP3207 dveB.Scer\UAS.T:Zzzz\FLAG midgut (with dve01738) dveE181 dveNP3060 midgut (with dveE181) dve01738 midgut (with dveNP3060) dve01738 midgut | heat sensitive, with Scer\GAL4NP3012 dveGD1425 midgut | heat sensitive, with Scer\GAL4NP3123 dveGD1425 midgut | heat sensitive, with Scer\GAL4NP3157 dveGD1425 midgut | heat sensitive, with Scer\GAL4NP3207 dveGD1425 midgut | heat sensitive, with Scer\GAL4NP3270 dveGD1425 midgut | heat sensitive, with Scer\GAL4NP3612 dveGD1425 proventriculus dveE181 proventriculus (with Df(2R)01D01W-L186) dve01738 proventriculus (with dve01738) dveE181 proventriculus (with dveE181) dve01738 proventriculus inner layer dve01738 proventriculus outer layer dve01738 tarsal segment | dorsal | pharate adult stage, with Scer\GAL4bi-md653 dve5.0.Scer\UAS tarsal segment | somatic clone dve01738 wing dve01738 wing, with Scer\GAL4vg.PM dveScer\UAS.cNa wing | proximal dve01738 wing | somatic clone dve01738 wing disc dve01738 wing disc | somatic clone dve01738 wing disc | somatic clone, with Scer\GAL4Act5C.PI dve5.0.Scer\UAS wing margin bristle | ectopic | somatic clone dve01738 wing vein L2 | proximal dve01738 wing vein L5 | distal dve01738
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of dve Class Mutagen Stocks Known lesion dveBG02382 P-element activity 2 Yes dvek06515 P-element activity 2 -- dve01738 hypomorphic allele - genetic evidence P-element activity 1 Yes dved04879 P-element activity 1 -- dved08355 1 -- dveEY10348 P-element activity 1 -- dvef07490b 1 -- dveKG10532 P-element activity 1 -- dveNP1550 1 -- dveNP3060 1 -- dveNP3428 1 -- dve01493 P-element activity 0 -- dve01704 P-element activity 0 -- dve01829 hypomorphic allele - genetic evidence P-element activity 0 Yes dve01D01W-L019 0 -- dve01D01W-L082 0 -- dve01D01W-L131 0 -- dve01D01W-L140 0 -- dve01D01W-L164 0 -- dve05084 hypomorphic allele - genetic evidence P-element activity 0 Yes dve06432 hypomorphic allele - genetic evidence P-element activity 0 Yes dved05100 0 -- dved07302 P-element activity 0 -- dved08715 P-element activity 0 -- dveE181 P-element activity 0 Yes dveE38 P-element activity 0 Yes dveE8 hypomorphic allele - genetic evidence P-element activity 0 -- dveND369 P-element activity 0 Yes dveSH0150 0 -- dveSH1292 0 -- dveSH255 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dve Class Mutagen Stocks Known lesion dveGD1425 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes dve5.0.Scer\UAS in vitro construct - regulatory fusion 1 Yes dveJF02123 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dveB.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dveKK115422 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dveScer\UAS.cNa in vitro construct - regulatory fusion 0 Yes dveScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)TE30Cb-1 (BDGP Project Members, 1994-1999) Df(2R)02311 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)BSC424 (Christensen et al., 2008.4.15) Df(2R)BSC597 (Christensen et al., 2008.9.3) Df(2R)X58-3 (Nakagoshi et al., 1998) Df(2R)X58-5 (Fuss and Hoch, 1998, Kolzer et al., 2003) Df(2R)X58-7 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)Pu-D17 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)XE3030 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1425} NA P{KK115422} NA P{TRiP.JF02123} NA P{UAS-dve.5.0} NA P{UAS-dve.N} NA P{UAS-dve.U} NA P{UAS-FLAG-dve.B} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{5'wHy}dve01D01W-L019 NA P{5'wHy}dve01D01W-L082 NA P{5'wHy}dve01D01W-L131 NA P{5'wHy}dve01D01W-L140 NA P{5'wHy}dve01D01W-L164 NA P{?PZ}dveE8 NA P{GT1}dveBG02382 NA P{PZ-ΔE38}dveE38 NA P{SUPor-P}dveKG10532 NA PBac{WH}dvef07490b NA insertion of enhancer trap P{FZ}dveSH255 No P{lacW}dvek06515 No P{lacW}dveSH0150 No P{lacW}dveSH1292 No P{lacW}l(2)SH1464SH1464 No P{PZ}dve01493 No P{PZ}dve01704 No P{PZ}dve01738 No P{PZ}dve01829 No P{PZ}dve05084 No P{PZ}dve06432 No insertion of mobile activating element P{EPgy2}dveEY10348 NA P{XP}d05100 NA P{XP}dved04879 NA P{XP}dved07302 NA P{XP}dved08355 NA P{XP}dved08715 NA insertion of enhancer trap binary system P{GalW}dveND369 No P{GawB}dveNP1550 No P{GawB}dveNP3060 No P{GawB}dveNP3428 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
copper ion import inferred from mutant phenotype (Nakagawa et al., 2011) imaginal disc-derived leg joint morphogenesis inferred from mutant phenotype (Ciechanska et al., 2007) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Kolzer et al., 2003) midgut development inferred from mutant phenotype (Nakagawa et al., 2011, Nakagoshi et al., 1998) negative regulation of transcription from RNA polymerase II promoter inferred from expression pattern (Ciechanska et al., 2007)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Nakagoshi et al., 1998)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
AT DNA binding inferred from sequence or structural similarity with UniProtKB:Q60611 (FlyBase, 1992-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with vvl (Nakagoshi et al., 1998) non-traceable author statement (FlyBase, 1992-) traceable author statement (Murakami et al., 1999)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with vvl (Nakagoshi et al., 1998) traceable author statement (Murakami et al., 1999)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dve - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dve allele Gene References dve01738 peb (Wilk et al., 2004) dvek06515 peb (Wilk et al., 2004) unspecified H (Mueller et al., 2005) p53 (Mueller et al., 2005) rpr (Mueller et al., 2005) W (Mueller et al., 2005)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020307 DroID - A comprehensive database of gene and protein interactions. • FBgn0020307 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37546
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62Z595 Dipteran inclusive ortholog search EOG6PNXR8 Insect inclusive ortholog search EOG6WDC72 Arthropod inclusive ortholog search EOG6RBP0W Metazoa inclusive ortholog search EOG696BK1
Orthologs in Drosophila Species (EOG62Z595)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dve     Drosophila sechellia   Dsec\GM15897 Y   Drosophila erecta   Dere\GG22176 Y   Drosophila yakuba   Dyak\GE14170 Y   Drosophila ananassae   Dana\GF12619 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19138 Y   Drosophila persimilis   Dper\GL17532 Y   Drosophila willistoni   Dwil\GK23702     Drosophila willistoni   Dwil\GK20806 Y   Drosophila willistoni   Dwil\GK18827     Drosophila willistoni   Dwil\GK10790     Drosophila willistoni   Dwil\GK23597     Drosophila willistoni   Dwil\GK24899     Drosophila willistoni   Dwil\GK21171     Drosophila willistoni   Dwil\GK16538     Drosophila willistoni   Dwil\GK24109     Drosophila virilis   Dvir\GJ15096 Y   Drosophila mojavensis   Dmoj\GI19929 Y   Drosophila grimshawi   Dgri\GH21453 Y
Orthologs in non-Drosophila Dipterans (EOG6PNXR8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012091   Anopheles gambiae Malaria mosquito  Agam\AGAP006642   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005190
Orthologs in non-Dipteran Insects (EOG6WDC72)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50892   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007611   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16780   Atta cephalotes Leafcutter ant  Acep\ACEP17090   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18805   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18460   Linepithema humile Argentine ant  Lhum\LH12934   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21141   Solenopsis invicta Red fire ant  Sinv\SINV11333   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009254   Bombyx mori Silkmoth  Bmor\BGIBMGA002615   Pediculus humanus Human body louse  Phum\PHUM502960   Tribolium castaneum Red flour beetle  Tcas\TC001741
Orthologs in non-Insect Arthropods (EOG6RBP0W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_302916   Ixodes scapularis Deer tick  Isca\ISCW015706
Orthologs in non-Arthropod Metazoa (EOG696BK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dve-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015151gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008753gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006623gn   Danio rerio Zebrafish  Drer\si:ch211-195k18.2
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM15897 Drosophila erecta Dere\GG22176 Drosophila yakuba Dyak\GE14170 Drosophila ananassae Dana\GF12619 Drosophila pseudoobscura pseudoobscura Dpse\GA19138 Drosophila persimilis Dper\GL17532 Drosophila willistoni Dwil\GK20806 Drosophila virilis Dvir\GJ15096 Drosophila mojavensis Dmoj\GI19929 Drosophila grimshawi Dgri\GH21453
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	7086 w*; P{UAS-dve.5.0}3 12859 w1118; P{GT1}dveBG02382/CyO 11073 cn1 P{PZ}dve01738/CyO; ry506 17670 y1 w67c23; P{EPgy2}dveEY10348 10399 y1 w67c23; P{lacW}dvek06515/CyO
Harvard	- P{XP}dved04879 - P{XP}dved08355 - PBac{WH}f07490a, PBac{WH}dvef07490b
Kyoto	104359 w*; P{GawB}dveNP3060
VDRC	v3780 w1118; P{GD1425}v3780 v3781 w1118; P{GD1425}v3781 v3782 w1118; P{GD1425}v3782
	More stocks available...
Genomic Clones ( 2 )
	BACR02I11 BACR02O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP14647 RE03646
Other clones	DPiM_IP14647
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE32537 RE56320 RH01118 RH01567 RH01704 RH03082 RH03239
Other clones	147528 160395 175971 179083 273282 CK01.21A.H7 CK01.76A.G9 CK01.125A.C11 EC051962 EC052472 EC054471 EC055515 EC056581 EK019432 EK059525 EK095412 EK263159 EK280959 IP14547 RP003011025 RP003014151 RP003020507 RP003045843 RP003089825 RP003110499 RP003123481 RP003173122 RP003179288 RP003186095 RP003195830 RP003196179 RP003214837 RP003220327 RP003230799 RP003232967 RP003238045 RP003241967 RP003244266 RP003255414 RP003255983 RP003319092 RP003374075 RP003390782 RP003391243 RP003416245 RP003423508 RP003430418 RP003434200 RP003454570 RP003455943 RP003456804 RP003488817 RP003493680 RP003500185 RP003582435 RP003599451 RP003617851 RP003627871 RP003643731 RP003662423 RP003665959
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020307 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37546
Antibody Information
	polyclonal (Nakagoshi et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dve CG5799 (Milshina, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dve isoform-A is important for proventriculus morphogenesis and functional development. (Nakagawa et al., 2011) dve is required at the foregut/midgut boundary for the formation of the proventriculus. (Fuss and Hoch, 1998) dve is required for midgut specification under the control of dpp and wg. (Nakagoshi et al., 1998) Identified during an enhancer trap screen for flies with an abnormal object fixation response. (Nakagoshi et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057893 NM_057894 RefSeq (Proteins) • NP_477241 NP_477242 DDBJ / EMBL / GenBank • AAF46827 AAM68216 AAM75052 AB010299 AC004252 AJ011671 AJ011672 AQ034163 AY128459 BAA32660 BH146146 BH146147 BI164075 BZ665777 CAA09729 CAA09730 CL526218 CZ474185 CZ475651 CZ476383 G00411 Entrez Gene - A searchable database of RefSeq genes. • 37546 UniProtKB/TrEMBL • O76143 O77289 Q8MLT6 Q8MQP8 Q9TYH1 Q9W268
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain (IPR001356) Homeodomain-like (IPR009057) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP14647 RE03646
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020307 DroID - A comprehensive database of gene and protein interactions. • FBgn0020307 DRSC - Results from RNAi screens. • FBgn0020307 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020307 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5799-RB;CG5799-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020307 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37546 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/defecpr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37546 modMine - Data generated by the modENCODE project. • FBgn0020307
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG5799 (Hadar et al., 2012, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Lowery et al., 2010) dep (Nakagoshi et al., 1997) Dve (Nakagoshi et al., 2003, Fuss, 1998.9.28, Koelzer and Klein, 2006, Ogasawara et al., 2006, Desprat et al., 2008, Perea et al., 2009) dve (Jacobsen et al., 2006, Blanco et al., 2010, Carr et al., 2005, Hadar et al., 2012, Hazelett et al., 2012, Christensen et al., 2008.4.15, Christensen et al., 2008.9.3, Huet et al., 2002, Strand and Micchelli, 2011, Johnston et al., 2011, Choksi et al., 2006, Tanaka et al., 2007, Lechner et al., 2007, Shirai et al., 2007, Ciechanska et al., 2007, Terriente et al., 2008, Weake et al., 2011, Veenstra, 2009, Salzer et al., 2010, Beltran et al., 2007, Hazelett et al., 2009, Nakagawa et al., 2011, Lowery et al., 2010, Gieger et al., 2011, Terrell et al., 2012, Busser et al., 2012) Dve-s (Fuss, 1998.9.28) l(2)01738 (Spradling et al., 1999, ) SATB1 (Gieger et al., 2011) unnamed (Treisman and Rubin, 1996)
Name Synonym	compass   defective proventriculus (Nakagoshi et al., 1997, Carr et al., 2005, Kankel et al., 2007, Strand and Micchelli, 2011, Johnston et al., 2011, Shirai et al., 2007, Ciechanska et al., 2007, Salzer et al., 2010, Nakagawa et al., 2011) Defective proventriculus (Perea et al., 2009)
Secondary FlyBase IDs
	FBgn0010496 FBgn0041142
References ( 81 )
Generate a list of	All references relating to this gene ( 81 )
List References by type	Research paper  ( 49 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 2 ) Website  ( 1 )
Recent research papers ( 14 )
	Adamson and Lajeunesse, 2012, ScientificWorldJournal 2012: 347597 A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. [FBrf0218446] Busser et al., 2012, PLoS Genet. 8(3): e1002531 A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis. [FBrf0217716] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Minami et al., 2012, PLoS ONE 7(3): e32302 The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila. [FBrf0217789] Sood et al., 2012, PLoS Comput. Biol. 8(2): e1002357 Stochastic De-repression of Rhodopsins in Single Photoreceptors of the Fly Retina. [FBrf0217438] Terrell et al., 2012, Dev. Dyn. 241(1): 215--228 OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. [FBrf0216943] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Gieger et al., 2011, Nature 480(7376): 201--208 New gene functions in megakaryopoiesis and platelet formation. [FBrf0216907] Johnston et al., 2011, Cell 145(6): 956--968 Interlocked feedforward loops control cell-type-specific rhodopsin expression in the Drosophila eye. [FBrf0213864] Nakagawa et al., 2011, Mech. Dev. 128(5-6): 258--267 Spatial and temporal requirement of Defective proventriculus activity during Drosophila midgut development. [FBrf0214038] Strand and Micchelli, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(43): 17696--17701 Quiescent gastric stem cells maintain the adult Drosophila stomach. [FBrf0216495] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Yorimitsu et al., 2011, Dev. Biol. 356(2): 598--607 Defective proventriculus specifies the ocellar region in the Drosophila head. [FBrf0214458] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...