• Home
• Tools
  • BLAST
  • GBrowse
  • QueryBuilder
  • TermLink
  • ImageBrowse
  • Interactions Browser
  • Apollo
  • CytoSearch
  • QuickSearch
  • Batch Download
  • Coordinate Converter
  • Google™ FlyBase
  • Find A Person
  • Update An Address
  • Add A New Person
• Files
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases FTP
  • Genomes FTP
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Synteny Table
  • Drosophilidae
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All resources
  • Interactive Fly
  • Textpresso for Fly
  • AAA site
  • BDGP
  • DHGP
  • DGRC
  • Model Organisms
  • Stock Collections:
  • Bloomington
  • DrosDel
  • Ehime
  • Exelixis (Harvard)
  • GDP (Baylor)
  • Kyoto
  • NIG-Fly
  • Szeged
  • Tucson
  • VDRC
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Known Problems
  • Contact FlyBase
• Archives
  • Prior Home Page
  • R4.3 BLAST
  • R4.3 GBrowse
  • Older Archives

Gene Dmel\dve

General Information
Symbol	Dmel\dve	Species	D. melanogaster
Name	defective proventriculus	Annotation symbol	CG5799
Feature type	protein_coding_gene	FlyBase ID	FBgn0020307
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58D2-58D2	Sequence location	2R:18,131,468..18,173,982 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene defective proventriculus is referred to in FlyBase by the symbol dve (CG5799, FBgn0020307). It has the cytological map location 58D2. Its sequence location is 2R:18131468..18173982. Its molecular function is described as: transcription factor activity; AT DNA binding. It is involved in the biological processes: midgut development; regulation of transcription, DNA-dependent; imaginal disc-derived wing morphogenesis; regulation of transcription. 19 alleles are reported. The phenotypes of these alleles are annotated with: wing; wing margin bristle; wing vein L2; wing vein L5; dorsal mesothoracic disc; cuprophilic cell; proventriculus outer layer; proventriculus inner layer. It has 2 annotated transcripts and 2 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58D2-58D2   Limits computationally determined from genome sequence between P{PZ}ari-207768 and P{lacW}l(2)k09801k09801
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58D1-58D2   (Nakagoshi, 1998.1.10) 58D1-58D2   (Fuss, 1998.9.28) 58D1-58D2 (determined by in situ hybridisation)   (Spradling et al., 1999) 58D1-58D2 58D1--3   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: mei-S332+ a+ ari-2+ dve+ (Liu and Lengyel, 2000) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\dve for information on other features
Comments on Gene Model
	SwissProt O77289 Real has additional DR in protein sequence following aa 198 such that its sequence starting at aa 180 isnatpksdReReReReRdRdr... whereas Swissprot O76143 and Q9TYH1 and transcripts RA-D have sequence natpksdReReReReRdR...starting at aa 180
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dve-RA FBtr0071775  NM_057894   4911   1024 dve-RB FBtr0071776  NM_057893   3475   780
Additional Transcript Data & Comments
Reported size (kB)	4.9 (longest cDNA) (Nakagoshi et al., 1998) 5.0, 1.7 (northern blot) (Fuss and Hoch, 1998)
Comments	The 5.0 kb transcript is absent in dve mutant embryos and larvae. (Fuss and Hoch, 1998)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein dve-PA   FBpp0071689   112.0   1024   6.64     NP_477242   AAF46827 dve-PB   FBpp0089292   85.8   780   6.40     NP_477241   AAM68216
Additional Polypeptide Data & Comments
Reported size (kD)	1021, 245 (aa) (Fuss and Hoch, 1998) 1019 (aa) (Nakagoshi et al., 1998)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0020307
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AB010299 BAA32660   AC004252   AE003456 AAF46827   AE003456 AAM68216   AJ011671 CAA09729   AJ011672 CAA09730   AQ034163   AY128459 AAM75052   BH146146   BH146147   BI164075   BI236478   BI369965   BI568815   BI569487   BI569601   BI589622   BI589756   BT025086   BZ665777   CL526218   CO179487   CO186411   CO269634   CO315942   CZ474185   CZ475651   CZ476383   EC051962   EC052472   EC054471   EC055515   EC056581   EC058504   EC066047   EC089346   EC089945   EC090042   EC229223   EC239630   EC243139   EL874518   G00411
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76143 O77289 Q8MLT6 Q8MQP8 Q9TYH1 Q9W268
Maps to	DS09121 (FlyBase, 1992-, Fuss and Hoch, 1998)
Does NOT map to
Identified with	RE03646 (BDGP Project Members, 2000-) Dm0005 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 1297
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage | stage >=9  anterior midgut primordium | restricted (Fuss and Hoch, 1998)  embryonic stage | stage 13  ventral nerve cord | restricted (Fuss and Hoch, 1998)  embryonic stage | stage 12  posterior midgut primordium | anterior (Fuss and Hoch, 1998)  embryonic stage | stage 12  embryonic/larval pharynx | vicinity of (Fuss and Hoch, 1998)  embryonic stage | stage 16  outer layer of proventriculus (Fuss and Hoch, 1998)  embryonic stage | stage 13-17  embryonic/larval midgut | restricted (Fuss and Hoch, 1998)  embryonic stage | 0-18 hr   (Fuss and Hoch, 1998)  embryonic stage | stage 13  embryonic brain | restricted (Fuss and Hoch, 1998)  embryonic stage | stage 9  mesectoderm | restricted (Fuss and Hoch, 1998)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  embryonic stage | stage 16  outer layer of proventriculus (Nakagoshi et al., 1998)  larval stage | third instar  dorsal mesothoracic disc | restricted (Kolzer et al., 2003)  embryonic stage | stage >=11  anterior midgut primordium | restricted (Nakagoshi et al., 1998)  embryonic stage | stage >=13  posterior embryonic/larval midgut | restricted (Nakagoshi et al., 1998)  embryonic stage | stage 16  specialised embryonic/larval midgut cell | precursor (Nakagoshi et al., 1998)  embryonic stage | stage >=13  mid embryonic/larval midgut | restricted (Nakagoshi et al., 1998)  embryonic stage | stage 10  stomodeum (Nakagoshi et al., 1998)
Marker for
	embryonic proventriculus outer layer
Subcellular Localization
CV Term	nucleus (Nakagoshi et al., 1998)
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020307 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0020307 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0020307 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for dve FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dve Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable dveEY10348 dveSH255 lethal dve01738 dvek06515 lethal (with Df(2R)X58-5) dve01738 lethal (with dve01738) dveBG02382 lethal (with dveBG02382) dve01738 lethal | recessive dve01493 dve01704 dve01738 dvek06515 lethal | larval stage | recessive dve01738 dve01829 dve05084 dve06432 Other Phenotypes Allele visible dve01738 visible | recessive | somatic clone dve01738 visible, with Scer\GAL4vg.PM dveScer\UAS.cNa Sterility Allele fertile dveEY10348 Phenotype manifest in Allele wing | somatic clone dve01738 wing margin bristle | ectopic | somatic clone dve01738 wing | proximal dve01738 wing dve01738 wing vein L2 | proximal dve01738 wing vein L5 | distal dve01738 dorsal mesothoracic disc dve01738 dorsal mesothoracic disc | somatic clone dve01738 larval proventriculus & embryo dve01738 cuprophilic cell dve01738 dveE38 proventriculus outer layer dve01738 proventriculus inner layer dve01738 dorsal mesothoracic disc | somatic clone, with Scer\GAL4Act5C.PI dve5.0.Scer\UAS cuprophilic cell, with Scer\GAL4hs.PB dveScer\UAS.cNa wing, with Scer\GAL4vg.PM dveScer\UAS.cNa
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of dve Class Mutagen Stocks Known lesion dve01493 P-element activity 0 -- dve01704 P-element activity 0 -- dve01738 hypomorph P-element activity 1 Yes dve01829 hypomorph P-element activity 0 Yes dve05084 hypomorph P-element activity 0 Yes dve06432 hypomorph P-element activity 0 Yes dveBG02382 P-element activity 1 Yes dveE38 P-element activity 0 Yes dveE8 hypomorph P-element activity 0 -- dveEY10348 P-element activity 1 -- dveKG10532 P-element activity 1 -- dveSH255 P-element activity 0 Yes dved04879 P-element activity 1 -- dved07302 P-element activity 0 -- dved08715 P-element activity 0 -- dvek06515 P-element activity 2 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dve Class Mutagen Stocks Known lesion dve5.0.Scer\UAS in vitro construct | regulatory fusion 1 Yes dveGD1425 in vitro construct | RNAi in vitro construct | regulatory fusion 3 Yes dveScer\UAS.cNa in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(2R)02311
Useful duplication	Dp(2;2)l-32
Disrupted in	Df(2L)TE30Cb-1 (BDGP Project Members, 1994-1999) Df(2R)02311 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)BSC424 (Christensen et al., 2008.4.15) Df(2R)X58-3 (Nakagoshi et al., 1998) Df(2R)X58-5 (Fuss and Hoch, 1998, Kolzer et al., 2003) Df(2R)X58-7 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)Pu-D17 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)XE3030 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1425} NA P{UAS-dve.5.0} NA P{UAS-dve.N} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?PZ}dveE8 NA P{GT1}dveBG02382 NA P{PZ-ΔE38}dveE38 NA P{SUPor-P}dveKG10532 NA insertion of enhancer trap P{FZ}dveSH255 No P{PZ}dve01493 No P{PZ}dve01704 No P{PZ}dve01738 Yes P{PZ}dve01829 No P{PZ}dve05084 No P{PZ}dve06432 No P{lacW}dvek06515 No P{lacW}l(2)SH1464SH1464 No insertion of mobile activating element P{EPgy2}dveEY10348 NA P{XP}dved04879 NA P{XP}dved07302 NA P{XP}dved08715 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 7 )
Molecular Function
CV term Evidence References
AT DNA binding inferred from sequence or structural similarity with UniProtKB:Q60611 (FlyBase, 1992-)
transcription factor activity inferred from sequence or structural similarity with FLYBASE:vvl; FB:FBgn0003995 (Nakagoshi et al., 1998) non-traceable author statement (FlyBase, 1992-) traceable author statement (Murakami et al., 1999)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Kolzer et al., 2003)
midgut development inferred from mutant phenotype (Nakagoshi et al., 1998)
regulation of transcription traceable author statement (Murakami et al., 1999)
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with FLYBASE:vvl; FB:FBgn0003995 (Nakagoshi et al., 1998)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (FlyBase, 1992-) inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dve allele Gene References dve01738 peb (Wilk et al., 2004) dvek06515 peb (Wilk et al., 2004) unspecified rpr (Mueller et al., 2005) W (Mueller et al., 2005) H (Mueller et al., 2005) p53 (Mueller et al., 2005)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 63163
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12619 Dere\GG22176 Dgri\GH21453 Dmoj\GI19929 Dper\GL17532 Dpse\GA19138 Dsec\GM15897 Dvir\GJ15096 Dwil\GK20806 Dyak\GE14170
Curated drosophilid orthologs	Dpse\GA19138
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000002626 Anopheles gambiae (Ensembl) WBGene00022861 Caenorhabditis elegans (Wormbase)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Harvard	- P{XP}dved04879
Bloomington	7086 w*; P{UAS-dve.5.0}3 12859 w1118; P{GT1}dveBG02382/CyO 11073 cn1 P{PZ}dve01738/CyO; ry506 17670 y1 w67c23; P{EPgy2}dveEY10348 10399 y1 w67c23; P{lacW}dvek06515/CyO 15276 y1; P{SUPor-P}dveKG10532; ry506
VDRC	v3780 w1118; P{GD1425}v3780 v3781 w1118; P{GD1425}v3781 v3782 w1118; P{GD1425}v3782
Szeged	- P{lacW}l(2)SH1464SH1464
Kyoto	102483 Df(1)w67c23, y1 ; P{lacW}dvek06515 / CyO
Genomic Clones ( 2 )
	BACR02O12 BACR02I11
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP14647 RE03646
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE56320 RE32537 RH01704 RH03082 RH03239 RH01567 RH01118
Other clones	EK059525 EK263159 EC052472 EC054471 EK095412 EK019432 EC055515 EC056581 IP14547 EC051962
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0020307 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data •