A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\dve

General Information
SymbolDmel\dveSpeciesD. melanogaster
Namedefective proventriculusAnnotation symbolCG5799
Feature typeprotein_coding_geneFlyBase IDFBgn0020307
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map58D2-58D2Sequence location2R:18,131,468..18,173,982 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene defective proventriculus is referred to in FlyBase by the symbol dve (CG5799, FBgn0020307). It has the cytological map location 58D2. Its sequence location is 2R:18131468..18173982. Its molecular function is described as: transcription factor activity; AT DNA binding. It is involved in the biological processes: midgut development; regulation of transcription, DNA-dependent; imaginal disc-derived wing morphogenesis; regulation of transcription. 19 alleles are reported. The phenotypes of these alleles are annotated with: wing; wing margin bristle; wing vein L2; wing vein L5; dorsal mesothoracic disc; cuprophilic cell; proventriculus outer layer; proventriculus inner layer. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
58D2-58D2  
Limits computationally determined from genome sequence between P{PZ}ari-207768 and P{lacW}l(2)k09801k09801  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
58D1-58D2
58D1-58D2
58D1-58D2
(determined by in situ hybridisation)  
58D1-58D2
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: mei-S332+ a+ ari-2+ dve+
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\dve for information on other features
detailed view FBtr0071775 FBtr0071776 FBpp0071689 FBpp0089292 FBti0005939 FBti0012272 FBti0069197 FBti0018107 FBti0058534 FBti0033009 FBti0033076 FBti0025118 FBti0005940 FBti0005941 FBti0068266 FBti0069706 FBti0025898 FBti0071099 FBti0039020 FBti0035416 FBti0056614 FBti0034477 FBti0033040 FBti0071162 FBti0005198 FBti0070019 FBti0033057 FBti0055668 FBti0033063 FBti0033087
Comments on Gene Model
SwissProt O77289 Real has additional DR in protein sequence following aa 198 such that its sequence starting at aa 180 isnatpksdReReReReRdRdr... whereas Swissprot O76143 and Q9TYH1 and transcripts RA-D have sequence natpksdReReReReRdR...starting at aa 180
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0071775
  4911
  1024
FBtr0071776
  3475
  780
Additional Transcript Data & Comments
Reported size (kB)
4.9 (longest cDNA)
5.0, 1.7 (northern blot)
Comments
The 5.0 kb transcript is absent in dve mutant embryos and larvae.
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
dve-PA  
FBpp0071689  
112.0  
1024  
6.64  
dve-PB  
FBpp0089292  
85.8  
780  
6.40  
Additional Polypeptide Data & Comments
Reported size (kD)
1021, 245 (aa)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Homeobox (IPR001356)
Homeodomain-like (IPR009057)
Homeodomain-related (IPR012287)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     embryonic stage | stage >=9
     anterior midgut primordium | restricted
     embryonic stage | stage 13
     ventral nerve cord | restricted
     embryonic stage | stage 12
     posterior midgut primordium | anterior
     embryonic stage | stage 12
     embryonic/larval pharynx | vicinity of
     embryonic stage | stage 16
     outer layer of proventriculus
     embryonic stage | stage 13-17
     embryonic/larval midgut | restricted
     embryonic stage | 0-18 hr
     embryonic stage | stage 13
     embryonic brain | restricted
     embryonic stage | stage 9
     mesectoderm | restricted
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
       embryonic stage | stage 16
       outer layer of proventriculus
       larval stage | third instar
       dorsal mesothoracic disc | restricted
       embryonic stage | stage >=11
       anterior midgut primordium | restricted
       embryonic stage | stage >=13
       posterior embryonic/larval midgut | restricted
       embryonic stage | stage 16
       specialised embryonic/larval midgut cell | precursor
       embryonic stage | stage >=13
       mid embryonic/larval midgut | restricted
       embryonic stage | stage 10
      Marker for
      Subcellular Localization
      CV Term
      hide External Data & Images
      Linkouts
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
      FlyExpress - Embryonic expression images (BDGP data)
      hide Alleles & Phenotypes
      hide Summary of Allele Phenotypes
      Lethality
      Allele
      Other Phenotypes
      Allele
      Sterility
      Allele
      Phenotype manifest in
      Allele
      larval proventriculus & embryo
      hide Classical Alleles ( 16 )
      For All Classical Alleles Show

      Allele of dveClassMutagenStocksKnown lesion
      dve014930 --
      dve017040 --
      dve01738hypomorph1 Yes
      dve01829hypomorph0 Yes
      dve05084hypomorph0 Yes
      dve06432hypomorph0 Yes
      dveBG023821 Yes
      dveE380 Yes
      dveE8hypomorph0 --
      dveEY103481 --
      dveKG105321 --
      dveSH2550 Yes
      dved048791 --
      dved073020 --
      dved087150 --
      dvek065152 --
      hide Alleles Carried on Transgenic Constructs ( 3 )
      For All Alleles Carried on Transgenic Constructs Show

      Allele of dveClassMutagenStocksKnown lesion
      dve5.0.Scer\UAS1 Yes
      dveGD14253 Yes
      dveScer\UAS.cNa0 Yes
      hide Aneuploid Aberrations
      Useful deficiency
      Useful duplication
      Disrupted in
      Not disrupted in
      hide Transgenic Constructs & Insertions
      Transgenic Constructs
      Type of construct
      Name
      Expression data
      UAS construct
      Insertions
      Type of insertions
      Name
      Expression data
      insertion of mobile activating element
      hide Related Comments
      Please look at the allele reports for the complete phenotype data
      hide Gene Ontology: Function, Process & Cellular Component ( 7 )
      hide Molecular Function
      CV term
      References
      inferred from sequence or structural similarity with UniProtKB:Q60611
      inferred from sequence or structural similarity with FLYBASE:vvl; FB:FBgn0003995
      non-traceable author statement
      traceable author statement
      hide Biological Process
      CV term
      References
      inferred from mutant phenotype
      inferred from mutant phenotype
      traceable author statement
      inferred from sequence or structural similarity with FLYBASE:vvl; FB:FBgn0003995
      hide Cellular Component
      CV term
      References
      non-traceable author statement
      inferred from electronic annotation with InterPro:IPR001356
      hide Sequence Ontology: Class of Gene
      hide Interactions & Pathways
      hide Summary of Genetic Interactions
      Interacts with
      Please look at the allele data for full details of the genetic interactions
      dve allele
      Gene
      References
      hide External Data
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      hide Orthologs
      Genome-wide drosophilid orthologs
      Curated drosophilid orthologs
      Linkouts
      InParanoid orthologs - Eukaryotic orthologs
      hide Functional Complementation between Species
      hide Inter-Species Misexpression Data
      Produces phenotype in
      Produces NO phenotype in
      hide Stocks & Reagents
      hide Stocks Listed in FlyBase ( 12 )
      Harvard
      Bloomington
      VDRC
      Szeged
      Kyoto
      hide Genomic Clones ( 2 )
      hide cDNA Clones ( 19 )
      Please Note
      This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
      cDNA Clones, Fully Sequenced
      BDGP DGC clones
      Other clones
      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      hide RNAi & Array Information
      Affy Oligo
      Linkouts
      DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data