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Gene Dmel\crol

General Information
Symbol	Dmel\crol	Species	D. melanogaster
Name	crooked legs	Annotation symbol	CG14938
Feature type	protein_coding_gene	FlyBase ID	FBgn0020309
Gene Model Status	Current	Stock availability	30 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33A1-33A2	Sequence location	2L:11,794,327..11,809,438 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crooked legs is referred to in FlyBase by the symbol Dmel\crol (CG14938, FBgn0020309). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: lateral inhibition; cell adhesion; negative regulation of Wnt receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of chromatin silencing; imaginal disc-derived wing morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of mitotic cell cycle. 53 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; thoracic segment; imaginal precursor; organ system; multicellular structure; portion of tissue; adult; appendage segment; stage P14 pharate adult; epithelial furrow. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult hindgut, adult heart, larval/adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626018_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of crol. Gene sequence location is 2L:11794327..11809438.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33A1-33A2   Limits computationally determined from genome sequence between P{PZ}salm03602 and P{PZ}crol04418&P{EP}crolEP1183
Experimentally Determined Cytological Location
Cytogenetic map Notes References 33A6-33A7     (D'Avino, 1997.8.21) 33A1-33A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 33A1-33A2   33A2--3 33A3--4   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\crol for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) crol-RA FBtr0080261  NM_057895   5936   962 crol-RB FBtr0080262  NM_057897   6047   891 crol-RC FBtr0080263  NM_057896   5642   756 crol-RD FBtr0080260  NM_164971   6207   878 crol-RE FBtr0305262  NM_001259064   6150   962 crol-RF FBtr0335473  NM_001273461   6184   907 crol-RG FBtr0335474  NM_001273462   6097   878 crol-RH FBtr0335475  NM_001273463   5631   686 crol-RI FBtr0335476  NM_001273464   5617   962
Additional Transcript Data & Comments
Reported size (kB)	6.0, 5.3 (northern blot) (D'Avino and Thummel, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein crol-PA   FBpp0079845   106.4   962   9.46     NP_477243   AAF53121 crol-PB   FBpp0079846   98.5   891   9.29     NP_477245   AAN10786 crol-PC   FBpp0079847   82.9   756   9.49     NP_477244   AAN10784 crol-PD   FBpp0079844   96.4   878   9.41     NP_723687   AAN10785 crol-PE   FBpp0293786   106.4   962   9.46     NP_001245993   AFH03667 crol-PF   FBpp0307448   99.6   907   9.43     NP_001260390   AGB92925 crol-PG   FBpp0307449   96.2   878   9.48     NP_001260391   AGB92926 crol-PH   FBpp0307450   75.1   686   9.25     NP_001260392   AGB92927 crol-PI   FBpp0307451   106.4   962   9.46     NP_001260393   AGB92928
Additional Polypeptide Data & Comments
Reported size (kDa)	962, 891, 756 (aa) (D'Avino and Thummel, 1998)
Comments	The beta form of crol protein has 16 zinc fingers. (D'Avino and Thummel, 1998) The alpha form of crol protein has 18 zinc fingers. (D'Avino and Thummel, 1998) The gamma form of crol protein has 12 zinc fingers. (D'Avino and Thummel, 1998)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441431   AA695157   AA698250   AE014134 AAF53121   AE014134 AAN10784   AE014134 AAN10785   AE014134 AAN10786   AC006240   AC093199   AF020347 AAC15516   AF020348 AAC15517   AF020349 AAC15518   AE014134 AFH03667   AE014134 AGB92925   AE014134 AGB92926   AE014134 AGB92927   AE014134 AGB92928   AI124287   AI124327   AI258817   AI259759   AI295061   AI405543   AI517279   AQ025047   AQ072919   AQ073413   AW941081   AW942415   AW943984   AY061538 AAL29086   AY119553 AAM50207   BI484352   BI484409   BI486290   BI578424   BI605378   BI606478   BI641377   CA805034   CL632180   CO178429   CO184094   CO262474   CO264006   CO268828   CO273751   CO274507   CO276458   CO280208   CO280381   CO283268   CO288875   CO289232   CO297947   CO303560   CO308063   CO311145   CO314313   CO317260   CO317463   CO318002   CO318731   CO328989   CO332584   CO333431   CO339550   CO339871   CO342260   CZ469369   CZ469415   CZ472089   CZ472178   CZ473248   CZ473349   CZ474964   CZ474965   CZ478437   CZ481775   CZ481897   CZ482574   CZ490444   CZ490510   CZ490785   EC058119   EC058716   EC062004   EC064771   EC066601   EC067932   EC068308   EC070471   EC071640   EC072086   EC081640   EC083785   EC195829   EC197568   EC204288   EC209877   EC210703   EC211263   EC212802   EC214984   EC219325   EC227018   EC235536   EC243036   EC245290   EC246567   EC253234   EC256026   EC258949   EC263547   ES693157   G00541   GH941530   GH942822   GH948420   GH948441   GH948877   GH950780   GH951600   GH955421   GH956441   GH957814   GH962034   GH962814   GH965298   GH967814   GH973266   GH973973   GH974999   GH975590   GH976396   GH977985   GH982559   GH984134
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O61360 O61361 O61362 Q8MRK4 Q95R99
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference third instar larval stage     (D'Avino and Thummel, 1998) prepupal stage     (D'Avino and Thummel, 1998)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Mitchell et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult hindgut, adult heart, larval/adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    832.725 Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain    796.6 Adult Thoracic-Abdominal Ganglion    548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (832.725) Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain  (796.6) Adult Thoracic-Abdominal Ganglion  (548.3) Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    832.725 Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain    796.6 Adult Thoracic-Abdominal Ganglion    548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    832.725 Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain    796.6 Adult Thoracic-Abdominal Ganglion    548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    832.725 Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain    796.6 Adult Thoracic-Abdominal Ganglion    548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (832.725) Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain  796.6 Adult Thoracic-Abdominal Ganglion  548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    832.725 Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain    796.6 Adult Thoracic-Abdominal Ganglion    548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    832.725 Larval Midgut    67.2 Larval Hindgut    136.9 Larval Malpighian Tubules    80 Larval Fat Body    54.7 Larval Salivary Gland    180.2 Larval Trachea    194.1 Larval Carcass    124.95 Adult Head    246.3 Adult Eye    239.875 Adult Brain    796.6 Adult Thoracic-Abdominal Ganglion    548.3 Adult Crop    147.7 Adult Midgut    68.5 Adult Hindgut    171.7 Adult Malpighian Tubules    59.4 Adult Fat Body    71 Adult Salivary Gland    159.2 Adult Heart    111.075 Adult VirginFemale Spermatheca    77.2 Adult InseminatedFemale Spermatheca    90.2 Adult Ovary    25.2 Adult Testis    19.2 Adult Male Accessory Gland    224.2 Adult Carcass    115.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    246.3   NA  Eye    239.875   NA  Brain    796.6   832.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    548.3   NA  Crop    147.7   67.2  Midgut    68.5   136.9  Hindgut    171.7   80  Malpighian Tubules    59.4   54.7  Fat Body    71   180.2  Salivary Gland    159.2   NA  Heart    111.075   194.1  Trachea    NA   NA  VirginFemale Spermatheca    77.2   NA  InseminatedFemale Spermatheca    90.2   NA  Ovary    25.2   NA  Testis    19.2   NA  Male Accessory Gland    224.2   124.95  Carcass    115.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    119 central nervous system, pupae P8    60 head, virgin 1-day female    27 head, virgin 4-day female    29 head, virgin 20-day female    18 head, mated 1-day female    31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male    40 head, mated 4-day male    38 head, mated 20-day male    35 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    30 carcass, larvae L3 wandering    58 carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    39 ovary, mated 4-day female    48 testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (75) central nervous system, larvae L3  (119) central nervous system, pupae P8  (60) head, virgin 1-day female  (27) head, virgin 4-day female  (29) head, virgin 20-day female    18 head, mated 1-day female  (31) head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male  (40) head, mated 4-day male  (38) head, mated 20-day male  (35) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (33) digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8  (30) carcass, larvae L3 wandering  (58) carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (48) testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3  (119) central nervous system, pupae P8    60 head, virgin 1-day female    27 head, virgin 4-day female    29 head, virgin 20-day female    18 head, mated 1-day female    31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male    40 head, mated 4-day male    38 head, mated 20-day male    35 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    30 carcass, larvae L3 wandering    58 carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    39 ovary, mated 4-day female    48 testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    119 central nervous system, pupae P8    60 head, virgin 1-day female    27 head, virgin 4-day female    29 head, virgin 20-day female    18 head, mated 1-day female    31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male    40 head, mated 4-day male    38 head, mated 20-day male    35 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    30 carcass, larvae L3 wandering    58 carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    39 ovary, mated 4-day female    48 testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    119 central nervous system, pupae P8    60 head, virgin 1-day female    27 head, virgin 4-day female    29 head, virgin 20-day female    18 head, mated 1-day female    31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male    40 head, mated 4-day male    38 head, mated 20-day male    35 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    30 carcass, larvae L3 wandering    58 carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    39 ovary, mated 4-day female    48 testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (75) central nervous system, larvae L3  (119) central nervous system, pupae P8  (60) head, virgin 1-day female  27 head, virgin 4-day female  29 head, virgin 20-day female    18 head, mated 1-day female  31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male  (40) head, mated 4-day male  (38) head, mated 20-day male  (35) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (33) digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8  30 carcass, larvae L3 wandering  (58) carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (48) testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3  119 central nervous system, pupae P8    60 head, virgin 1-day female    27 head, virgin 4-day female    29 head, virgin 20-day female    18 head, mated 1-day female    31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male    40 head, mated 4-day male    38 head, mated 20-day male    35 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    30 carcass, larvae L3 wandering    58 carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    39 ovary, mated 4-day female    48 testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    119 central nervous system, pupae P8    60 head, virgin 1-day female    27 head, virgin 4-day female    29 head, virgin 20-day female    18 head, mated 1-day female    31 head, mated 4-day female    25 head, mated 20-day female    20 head, mated 1-day male    40 head, mated 4-day male    38 head, mated 20-day male    35 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    15 fat body, white prepupae    25 fat body, pupae P8    30 carcass, larvae L3 wandering    58 carcass, 1-day adult    19 carcass, 4-day adult    21 carcass, 20-day adult    22 ovary, virgin 4-day female    39 ovary, mated 4-day female    48 testis, mated 4-day male    6 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    52 embryo 08-10hr    60 embryo 10-12hr    56 embryo 12-14hr    54 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    32 embryo 20-22hr    25 embryo 22-24hr    26 larva L1    35 larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    45 white prepupae new    57 white prepupae 12hr    61 white prepupae 24hr    73 pupae 2d postWPP    32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day    27 adult female 01day    36 adult female 05day    32 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr  (52) embryo 08-10hr  (60) embryo 10-12hr  (56) embryo 12-14hr  (54) embryo 14-16hr  (46) embryo 16-18hr  (35) embryo 18-20hr  (32) embryo 20-22hr    25 embryo 22-24hr  26 larva L1  (35) larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (42) larva L3 puffstage 7-9  (45) white prepupae new  (57) white prepupae 12hr  (61) white prepupae 24hr  (73) pupae 2d postWPP  (32) pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day  (27) adult female 01day  (36) adult female 05day  (32) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    52 embryo 08-10hr    60 embryo 10-12hr    56 embryo 12-14hr    54 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    32 embryo 20-22hr    25 embryo 22-24hr    26 larva L1    35 larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    45 white prepupae new    57 white prepupae 12hr    61 white prepupae 24hr    73 pupae 2d postWPP    32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day    27 adult female 01day    36 adult female 05day    32 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    52 embryo 08-10hr    60 embryo 10-12hr    56 embryo 12-14hr    54 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    32 embryo 20-22hr    25 embryo 22-24hr    26 larva L1    35 larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    45 white prepupae new    57 white prepupae 12hr    61 white prepupae 24hr    73 pupae 2d postWPP    32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day    27 adult female 01day    36 adult female 05day    32 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    52 embryo 08-10hr    60 embryo 10-12hr    56 embryo 12-14hr    54 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    32 embryo 20-22hr    25 embryo 22-24hr    26 larva L1    35 larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    45 white prepupae new    57 white prepupae 12hr    61 white prepupae 24hr    73 pupae 2d postWPP    32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day    27 adult female 01day    36 adult female 05day    32 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr  (52) embryo 08-10hr  (60) embryo 10-12hr  (56) embryo 12-14hr  (54) embryo 14-16hr  (46) embryo 16-18hr  (35) embryo 18-20hr  32 embryo 20-22hr    25 embryo 22-24hr  26 larva L1  (35) larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (42) larva L3 puffstage 7-9  (45) white prepupae new  (57) white prepupae 12hr  (61) white prepupae 24hr  (73) pupae 2d postWPP  32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day  27 adult female 01day  (36) adult female 05day  32 adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    52 embryo 08-10hr    60 embryo 10-12hr    56 embryo 12-14hr    54 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    32 embryo 20-22hr    25 embryo 22-24hr    26 larva L1    35 larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    45 white prepupae new    57 white prepupae 12hr    61 white prepupae 24hr    73 pupae 2d postWPP    32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day    27 adult female 01day    36 adult female 05day    32 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    52 embryo 08-10hr    60 embryo 10-12hr    56 embryo 12-14hr    54 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    32 embryo 20-22hr    25 embryo 22-24hr    26 larva L1    35 larva L2    18 larva L3 12hr old    19 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    45 white prepupae new    57 white prepupae 12hr    61 white prepupae 24hr    73 pupae 2d postWPP    32 pupae 3d postWPP    17 pupae 4d postWPP    22 adult male 01day    21 adult male 05day    24 adult male 30day    27 adult female 01day    36 adult female 05day    32 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    40 embryonic 1182-4H    45 embryonic GM2    49 embryonic Kc167    79 embryonic S1    87 embryonic S3    43 leg disc CME L1    44 wing disc CME-W2    39 wing disc ML-DmD8    59 wing disc ML-DmD9    57 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    46 wing disc ML-DmD32    59 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    60 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    54 ovary fGS/OSS    133 ovary OSC    95 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (59) Schneider line 2 Sg4  (40) embryonic 1182-4H  (45) embryonic GM2  (49) embryonic Kc167  (79) embryonic S1  (87) embryonic S3  (43) leg disc CME L1  (44) wing disc CME-W2  (39) wing disc ML-DmD8  (59) wing disc ML-DmD9  (57) wing disc ML-DmD16-c3  (70) wing disc ML-DmD21  (46) wing disc ML-DmD32  (59) haltere disc ML-DmD17-c3  (65) eye-antennal disc ML-DmD11  (52) antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1  (55) CNS ML-DmBG1-c1  (60) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (54) ovary fGS/OSS  (133) ovary OSC  (95) ovary OSS  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    40 embryonic 1182-4H    45 embryonic GM2    49 embryonic Kc167    79 embryonic S1    87 embryonic S3    43 leg disc CME L1    44 wing disc CME-W2    39 wing disc ML-DmD8    59 wing disc ML-DmD9    57 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    46 wing disc ML-DmD32    59 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    60 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    54 ovary fGS/OSS  (133) ovary OSC    95 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    40 embryonic 1182-4H    45 embryonic GM2    49 embryonic Kc167    79 embryonic S1    87 embryonic S3    43 leg disc CME L1    44 wing disc CME-W2    39 wing disc ML-DmD8    59 wing disc ML-DmD9    57 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    46 wing disc ML-DmD32    59 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    60 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    54 ovary fGS/OSS    133 ovary OSC    95 ovary OSS    59 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    40 embryonic 1182-4H    45 embryonic GM2    49 embryonic Kc167    79 embryonic S1    87 embryonic S3    43 leg disc CME L1    44 wing disc CME-W2    39 wing disc ML-DmD8    59 wing disc ML-DmD9    57 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    46 wing disc ML-DmD32    59 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    60 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    54 ovary fGS/OSS    133 ovary OSC    95 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (59) Schneider line 2 Sg4  (40) embryonic 1182-4H  (45) embryonic GM2  (49) embryonic Kc167  (79) embryonic S1  (87) embryonic S3  (43) leg disc CME L1  (44) wing disc CME-W2  (39) wing disc ML-DmD8  (59) wing disc ML-DmD9  (57) wing disc ML-DmD16-c3  (70) wing disc ML-DmD21  (46) wing disc ML-DmD32  (59) haltere disc ML-DmD17-c3  (65) eye-antennal disc ML-DmD11  (52) antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1  (55) CNS ML-DmBG1-c1  (60) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (54) ovary fGS/OSS  (133) ovary OSC  (95) ovary OSS  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    40 embryonic 1182-4H    45 embryonic GM2    49 embryonic Kc167    79 embryonic S1    87 embryonic S3    43 leg disc CME L1    44 wing disc CME-W2    39 wing disc ML-DmD8    59 wing disc ML-DmD9    57 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    46 wing disc ML-DmD32    59 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    60 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    54 ovary fGS/OSS  133 ovary OSC    95 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    40 embryonic 1182-4H    45 embryonic GM2    49 embryonic Kc167    79 embryonic S1    87 embryonic S3    43 leg disc CME L1    44 wing disc CME-W2    39 wing disc ML-DmD8    59 wing disc ML-DmD9    57 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    46 wing disc ML-DmD32    59 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    60 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    54 ovary fGS/OSS    133 ovary OSC    95 ovary OSS    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  (31) heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3  (31) Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3  (30) Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (32) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3  31 Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3  30 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH27971 LP02106 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020309 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14938-RD FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for crol Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal crol06470 crolk08217 lethal, with Scer\GAL4Act5C.PI crolLAJJ2A lethal | pupal stage | recessive crol04418 lethal | recessive crol11 crol04418 crol06470 crol10639 crolk05205 crolk08217 crolk09625 crolk14612 crols2346 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 crolGD1410 viable crol1ex15 crol3ex5 crolCB03039 crold03228 crolEY08953 Sterility Allele fertile crol1ex15 crold03228 crolEY08953 Other Phenotypes Allele cell death defective, with Scer\GAL4ey.PH crolunspecified gravitaxis defective | female limited crolBG00346 increased cell death, with Scer\GAL4en-e16E crolScer\UAS.cMa long lived | male limited crolBG00346 mitotic cell cycle defective, with Scer\GAL4en-e16E crolScer\UAS.cMa mitotic cell cycle defective | somatic clone crolk05205 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 crolEP2226 starvation stress response defective crolBG00346 temperature response defective crolBG00346 visible, with Scer\GAL4en-e16E crolScer\UAS.cMa visible, with Scer\GAL4pnr-MD237 crolGD1410 Phenotype manifest in Allele adult head crol04418 chaeta | supernumerary, with Scer\GAL4pnr-MD237 crolGD1410 femur crol06470 crolk08217 intersegmental nerve, with Scer\GAL4elav-C155 crolEP2226 leg crol04418 crol06470 crolk08217 macrochaeta crolBG00346 crolBG01255 crolBG01256 mesothoracic tergum, with Scer\GAL4pnr-MD237 crolGD1410 metathoracic femur crol04418 metathoracic leg crol04418 metathoracic leg sensillum crol04418 morphogenetic furrow, with Scer\GAL4ey.PH crolunspecified pupa crol04418 stage P5 pupa crol04418 stage P14 pharate adult crol04418 ventral thoracic disc crol04418 crolk08217 wing crol06470 crolk08217 wing | posterior compartment, with Scer\GAL4en-e16E crolScer\UAS.cMa wing disc, with Scer\GAL4en-e16E crolScer\UAS.cMa wing pouch, with Scer\GAL4en-e16E crolScer\UAS.cMa wing pouch | somatic clone crolk05205 wing vein | ectopic crol1ex15
Classical Alleles ( 48 )
For All Classical Alleles Show
Allele of crol Class Mutagen Stocks Known lesion crolk05205 P-element activity 2 -- crol04418 P-element activity 1 Yes crol11 1 Yes crol5-HA-1713 1 -- crolc04610 piggyBac transposase 1 -- crolc04670 piggyBac transposase 1 -- crolCB-6231-3 1 -- crolCB-6679-3 1 -- crold01205 P-element activity 1 -- crold01351 P-element activity 1 -- crold03228 P-element activity 1 -- crold03416 P-element activity 1 -- crold06178 P-element activity 1 -- crole00560 piggyBac transposase 1 -- crole04017 piggyBac transposase 1 -- crolf00090 piggyBac transposase 1 -- crolf07710 piggyBac transposase 1 -- crolf08081 piggyBac transposase 1 -- crolk08217 P-element activity 1 Yes crolk14612 P-element activity 1 -- crolKG08183 1 -- crolNP0775 1 -- crolNP2213 1 -- crolNP2764 1 -- crolNP3486 1 -- crolNP6319 1 -- crol06470 P-element activity 0 Yes crol10639 P-element activity 0 -- crol1ex15 hypomorphic allele - genetic evidence Delta2-3 0 Yes crol3ex5 Delta2-3 0 Yes crolBG00346 P-element activity 0 Yes crolBG01255 P-element activity 0 Yes crolBG01256 P-element activity 0 Yes crolCB03039 P-element activity 0 Yes crole04148 piggyBac transposase 0 -- crolE8 Delta2-3 0 Yes crolEP1183 P-element activity 0 -- crolEP2119 P-element activity 0 -- crolEP2226 P-element activity 0 Yes crolEY08953 P-element activity 0 -- crolf07773 piggyBac transposase 0 -- crolGS2267 0 Yes crolk09625 P-element activity 0 -- crolLAJJ2A P-element activity 0 -- crolNP3187 0 -- crolrev4 Delta2-3 0 Yes crols2346 P-element activity 0 -- crolunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of crol Class Mutagen Stocks Known lesion crolGD1410 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crolHMS02202 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crolKK107361 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crolNIG.14938R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes crolScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC237 (Christensen and Cook, 2006.12.5) Df(2L)BSC244 (Christensen and Cook, 2006.12.5) Df(2L)esc10 (D'Avino and Thummel, 1998) Df(2L)Prl (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2L)CycYE8 (Liu and Finley, 2010)
Partially disrupted in	Df(2L)CycYE8 (Liu and Finley, 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1410} NA P{KK107361} NA P{NIG.14938R} NA P{TRiP.HMS02202} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}crolEP1183 NA P{EP}crolEP2119 NA P{EP}crolEP2226 NA P{EPgy2}crolEY08953 NA P{GSV1}crolGS2267 NA P{GSV1}EP-IbEP-Ib NA P{Mae-UAS.6.11}crolLAJJ2A NA P{XP}crold01205 NA P{XP}crold01351 NA P{XP}crold03228 NA P{XP}crold03416 NA P{XP}crold06178 NA insertion of enhancer trap P{lacW}crolk05205 No P{lacW}crolk08217 No P{lacW}crolk09625 No P{lacW}crolk14612 No P{lacW}crols2346 No P{lacW}l(2)SH0889SH0889 No P{PZ}crol04418 No P{PZ}crol06470 No P{PZ}crol10639 No miscellaneous insertions P{GT1}crolBG00346 NA P{GT1}crolBG01255 NA P{GT1}crolBG01256 NA P{PTT-GB}crolCB03039 NA P{RS3}crolCB-6231-3 NA P{RS3}crolCB-6679-3 NA P{RS5}crol5-HA-1713 NA P{SUPor-P}crolKG08183 NA P{UASp-YFP.Rab9.S26N}crol11 NA PBac{PB}crolc04610 NA PBac{PB}crolc04670 NA PBac{RB}crole00560 NA PBac{RB}crole04017 NA PBac{RB}crole04148 NA PBac{WH}crolf00090 NA PBac{WH}crolf07710 NA PBac{WH}crolf07773 NA PBac{WH}crolf08081 NA insertion of enhancer trap binary system P{GawB}crolNP0775 No P{GawB}crolNP2213 No P{GawB}crolNP2764 No P{GawB}crolNP3187 No P{GawB}crolNP3486 No P{GawB}crolNP6319 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from mutant phenotype (D'Avino and Thummel, 2000) imaginal disc-derived wing morphogenesis inferred from genetic interaction with if AND inferred from genetic interaction with mys AND inferred from mutant phenotype (D'Avino and Thummel, 2000) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Mitchell et al., 2008) negative regulation of Wnt receptor signaling pathway inferred from genetic interaction with arm (Mitchell et al., 2008) inferred from genetic interaction with Axn (Mitchell et al., 2008) positive regulation of mitotic cell cycle inferred from mutant phenotype (Mitchell et al., 2008) regulation of chromatin silencing inferred from mutant phenotype (Schneiderman et al., 2010) regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (D'Avino and Thummel, 2000)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Mitchell et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase II promoter inferred from sequence or structural similarity with EMBL:AF082568 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
crol - CalpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) crol - Pabp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions crol allele Gene References crol3ex5 if (D'Avino and Thummel, 2000) mys (D'Avino and Thummel, 2000) crol04418 if (D'Avino and Thummel, 2000) crol06470 if (D'Avino and Thummel, 2000) crolk08217 if (D'Avino and Thummel, 2000) mys (D'Avino and Thummel, 2000) unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60645 DroID - A comprehensive database of gene and protein interactions. • FBgn0020309 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34592
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22157 Drosophila sechellia Dsec\GM10968 Drosophila erecta Dere\GG10297 Drosophila yakuba Dyak\GE12687 Drosophila ananassae Dana\GF23400 Drosophila pseudoobscura pseudoobscura Dpse\GA25849 Drosophila persimilis Dper\GL18890 Drosophila willistoni Dwil\GK14973 Drosophila virilis Dvir\GJ17478 Drosophila mojavensis Dmoj\GI17692 Drosophila grimshawi Dgri\GH13073
Stocks & Reagents
Stocks Listed in FlyBase ( 30 )
Harvard	- P{XP}crold01205 - P{XP}crold01351 - P{XP}crold03228 - P{XP}crold03416 - P{XP}crold06178 - PBac{PB}crolc04610 - PBac{PB}crolc04670 - PBac{RB}crole00560 - PBac{RB}crole04017 - PBac{WH}crolf00090 - PBac{WH}crolf07710
VDRC	v104313 P{KK107361}VIE-260B
	More stocks available...
Genomic Clones ( 1 )
	BACR05B13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 94 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH27971 LP02106
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH25569 GM02329 HL04029 LP03246 LP08582 RE67439 RE67504 RE69706 RE72293 RH70968 RH72971 SD24644
Other clones	57 29352 40197 42300 43480 53669 63825 71321 77007 100926 152984 163084 163929 166164 281495 300858 AI124287 AI124327 CK01.63A.C5 CK01.71B.H8 CK01.88B.H2 CK01.89C.H11 CK01.101B.A4 CK01.101B.H9 CK01.116A.C6 CK01.121B.B10 EC27093 EC256026 EC258949 EK056664 EK069561 EK070524 EK085434 EK092837 EK112107 EK114313 EK120916 EK137136 EK153405 EK153928 EK162735 EK170964 EK223463 EK235736 EK242108 EK256541 EK267450 EK268245 EK270004 EK273703 EK291813 EK304001 EK306925 EP02237 EP09540 EP14313 ESG0116b.B21_B04 LD16361 RP004050209 RP004079322 RP004097585 RP004156906 RP004164317 RP004192584 RP004199441 RP004199912 RP004201334 RP004219868 RP004254384 RP004265058 RP004266388 RP004320333 RP004339851 RP004352046 RP004372490 RP004384462 RP004462670 RP004493754 RP004521378 RP004529396
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020309 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34592
Antibody Information
	polyclonal (Mitchell et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: crol anon-EST:Liang-1.74 anon-EST:Liang-2.48 (Ashburner, 2004.6.30)
Additional comments
Other Comments
	EcR together with crol controls wing morphogenesis and cell adhesion by regulating integrin expression during metamorphosis. (D'Avino and Thummel, 2000) crol mutations specifically affect the transcription of a number of ecdysone-induced genes during the prepupal-pupal transition. (D'Avino and Thummel, 1998) crol is required for proper ecdysone-regulated gene expression during metamorphosis. (D'Avino and Thummel, 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057895 NM_057896 NM_057897 NM_164971 NM_001259064 NM_001273461 NM_001273462 NM_001273463 NM_001273464 RefSeq (Proteins) • NP_477243 NP_477244 NP_477245 NP_723687 NP_001245993 NP_001260390 NP_001260391 NP_001260392 NP_001260393 DDBJ / EMBL / GenBank • AA441431 AAC15516 AAC15517 AAC15518 AAF53121 AAL29086 AAM50207 AAN10784 AAN10785 AAN10786 AC006240 AC093199 AF020347 AF020348 AF020349 AFH03667 AGB92925 AGB92926 AGB92927 AGB92928 AI124287 AI124327 AI258817 AI517279 AQ025047 AQ072919 AQ073413 AW941081 AW942415 AW943984 AY061538 AY119553 CL632180 CZ469369 CZ469415 CZ472089 CZ472178 CZ473248 CZ473349 CZ474964 CZ474965 CZ478437 CZ481775 CZ481897 CZ482574 CZ490444 CZ490510 CZ490785 G00541 Entrez Gene - A searchable database of RefSeq genes. • 34592 UniProtKB/TrEMBL • O61360 O61361 O61362 Q8MRK4 Q95R99
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH27971 LP02106
Linkouts
	BioGRID - A database of protein and genetic interactions • 60645 DroID - A comprehensive database of gene and protein interactions. • FBgn0020309 DRSC - Results from RNAi screens. • FBgn0020309 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020309 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14938-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020309 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34592 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/crkdlg1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34592 modMine - Data generated by the modENCODE project. • FBgn0020309
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	anon-EST:Liang-1.74   anon-EST:Liang-2.48   CG14938 (Ashburner, 2004.6.30, Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Quinones-Coello, 2007, Molnar et al., 2006, Ida et al., 2009, Keleman et al., 2009.8.5, Maia et al., 2007, Schneiderman et al., 2010, Ni et al., 2010.12.1) clone 1.74 (Liang and Biggin, 1998) clone 2.48 (Liang and Biggin, 1998) crol (Jordan et al., 2006, Christensen and Cook, 2006.12.5, Altenhein et al., 2006, Christensen and Cook, 2006.12.5, Buszczak et al., 2007, Quinones-Coello, 2007, Zhang et al., 2007, Molnar et al., 2006, Kaltenbach et al., 2007, Cukier et al., 2008, Mitchell et al., 2008, Ida et al., 2009, Dworkin et al., 2009, Liu and Finley, 2010, Maia et al., 2007, Mourikis et al., 2010, Schneiderman et al., 2010, Beltran et al., 2007, Magwire et al., 2010, Abruzzi et al., 2011, Popkova et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Antao et al., 2012) Crol (Rendina et al., 2010) crol alpha (D'Avino, 1997.8.21) crol beta (D'Avino, 1997.8.21) crol gamma (D'Avino, 1997.8.21) l(2)04418   l(2)s2346   ORE-15 (Maia et al., 2007)
Name Synonym	crooked legs (D'Avino and Thummel, 1997, Jordan et al., 2006, Gregory et al., 2007, Kaltenbach et al., 2007, Magwire et al., 2010, Cukier et al., 2008, Harbison et al., 2005, Mourikis et al., 2010) Crooked legs (Mitchell et al., 2008) crooked-legs (Schneiderman et al., 2010)
Secondary FlyBase IDs
	FBgn0010573 FBgn0010685 FBgn0025949 FBgn0025978
References ( 81 )
Generate a list of	All references relating to this gene ( 81 )
List References by type	Research paper  ( 37 ) Supplementary material  ( 12 ) Review  ( 2 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Popkova et al., 2012, PLoS Genet. 8(12): e1003159 Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...