Pros45, p42C, DUG
Please see the JBrowse view of Dmel\Rpt6 for information on other features
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Gene model reviewed during 5.52
Supported by strand-specific RNA-Seq data.
1.35 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
405 (aa)
405 (aa); 43 (kD observed)
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts with Rpn6 (PubMed:22187461). Interacts with imd and Usp2 isoform A (PubMed:25027767).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rpt6 using the Feature Mapper tool.
Comment: maternally deposited
Rpt6 transcripts are uniformly distributed in early embryos. By the cellular blastoderm stage they are located primarily in the pole cells and in a layer between the newly formed epidermal cells and the yolk platelets. At stage 8, expression is mainly in the pole cells and in cells undergoing morphogenetic movement. At stage 13, transcripts are found in the germ band and in the anterior and posterior midgut primordia. In late embryos and in 1st instar larvae, expression is strongest in the CNS.
Rpt6 transcripts are expressed at all developmental stages and in adult males and females.
Rpt6 protein is detected at all developmental stages tested.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Rpt6 in GBrowse 21-65
1-65
1-65.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Pros45 CG1489
Source for identity of: Rpt6 Pros45
The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms.
"DUG" reported in FBrf0101966 and "Pros45" reported in this paper share 99% protein sequence identity and are the same gene (Pros45).
Expression is enriched in embryonic gonads.