FB2020_03, released Jun 16, 2020

Gene: Dmel\Dredd

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General Information
Symbol
Dmel\Dredd
Species
D. melanogaster
Name
Death related ced-3/Nedd2-like caspase
Annotation Symbol
CG7486
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020381
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Death related ced-3/Nedd2-like caspase (Dredd) encodes a protein that functions downstream of Fadd, and is thought to activate by cleavage the transcription factor encoded by Rel in the immune deficiency pathway. This pathway regulates the antibacterial response and other less characterized cellular processes. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Dcp-2/Dredd, EG:115C2.9 , Dcp-2, Dcp2

Key Links
Genomic Location
Cytogenetic map
1B12-1B13
Sequence location
X:633,622..635,545 [-]
Recombination map

1-0

RefSeq locus
NC_004354 REGION:633622..635545
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cysteine-type endopeptidase activator activity involved in apoptotic process
inferred from mutant phenotype
(assigned by UniProt )
(Chen et al., 1998)
endopeptidase activity
inferred from direct assay
(Paquette et al., 2010, Ertürk-Hasdemir et al., 2009)
protein binding
inferred from physical interaction with FLYBASE:Fadd; FB:FBgn0038928
(Hu and Yang, 2000)
inferred from physical interaction with UniProtKB:Q94527
(assigned by UniProt )
(Leulier et al., 2000)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
cysteine-type endopeptidase activity
traceable author statement
(Brachmann and Cagan, 2003, Richardson and Kumar, 2002, Kumar and Doumanis, 2000, Tittel and Steller, 2000, Abrams, 1999)
cysteine-type endopeptidase activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000047947
(assigned by GO_Central )
(Gaudet et al., 2011)
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000047948
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (15 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
apoptotic process
inferred from mutant phenotype
(assigned by UniProt )
(Chen et al., 1998)
defense response
inferred from mutant phenotype
(Elrod-Erickson et al., 2000)
defense response to Gram-negative bacterium
inferred from mutant phenotype
(Meinander et al., 2012, Wang et al., 2012, Berkey et al., 2009)
inferred from mutant phenotype
(assigned by UniProt )
(Jang et al., 2006, Leulier et al., 2000)
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
immune response
inferred from mutant phenotype
(Ryu et al., 2006)
negative regulation of programmed cell death
inferred from mutant phenotype
(Berkey et al., 2009)
peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Meinander et al., 2012, Ertürk-Hasdemir et al., 2009, Valanne et al., 2007, Zhou et al., 2005, Leulier et al., 2000)
inferred from mutant phenotype
(assigned by UniProt )
(Jang et al., 2006)
inferred from direct assay
(Paquette et al., 2010)
inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323
(Delaney et al., 2006)
peripheral nervous system neuron development
inferred from mutant phenotype
(Ayyar et al., 2007)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from mutant phenotype
(assigned by UniProt )
(Jang et al., 2006)
positive regulation of defense response to virus by host
inferred from mutant phenotype
(Avadhanula et al., 2009)
positive regulation of innate immune response
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
protein processing
inferred from direct assay
(Ertürk-Hasdemir et al., 2009)
sperm individualization
inferred from mutant phenotype
(Huh et al., 2004)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
activation of cysteine-type endopeptidase activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000047948
(assigned by GO_Central )
(Gaudet et al., 2011)
apoptotic process
traceable author statement
(Richardson and Kumar, 2002, Kimbrell and Beutler, 2001, Kumar and Doumanis, 2000)
non-traceable author statement
(Lawen, 2003)
inferred from biological aspect of ancestor with PANTHER:PTN000047947
(assigned by GO_Central )
(Gaudet et al., 2011)
immune response
traceable author statement
(Kimbrell and Beutler, 2001)
innate immune response
traceable author statement
(Kumar and Doumanis, 2000)
positive regulation of antibacterial peptide biosynthetic process
traceable author statement
(Richardson and Kumar, 2002, Kumar and Doumanis, 2000)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(assigned by UniProt )
(Chen et al., 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000047947
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase C14A family. (Q8IRY7)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CASPASES -
Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. (Adapted from FBrf0215539).
Pathway (FlyBase)
Imd Signaling Pathway Core Components -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
Protein Function (UniProtKB)
Effector of the programmed cell death (PCD) activators rpr, grim and hid (PubMed:9740659). May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (PubMed:10934188). Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection (PubMed:11269502). Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA (PubMed:22549468).
(UniProt, Q8IRY7)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Dredd or the JBrowse view of Dmel\Dredd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dredd-RD
FBtr0114559
NM_057903
1613
488
Dredd-RE
FBtr0114560
NM_057901
1631
494
Dredd-RF
FBtr0114561
NM_057902
1689
284
Dredd-RG
FBtr0340083
NM_001297822
1650
440
Additional Transcript Data and Comments
Reported size (kB)

1.708, 1.694 (longest cDNA)

(Chen et al., 1998)

1.7, 1.5 (northern blot)

(Voelker et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dredd-PD
FBpp0113051
55.5
488
6.95
NP_477251
AAN09022
Dredd-PE
FBpp0113052
56.2
494
6.95
NP_477249
AAF45533
Dredd-PF
FBpp0113053
32.2
284
7.00
NP_477250
AAN09023
Dredd-PG
FBpp0309082
50.0
440
7.83
NP_001284751
AHN59222
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

494, 488 (aa)

(Chen et al., 1998)
Comments

When apoptosis is triggered by the expression of rpr, grim, or W proteins, caspase-like processing of the the α, γ, and δ isoforms of Dredd protein occurs. (It is likely that the putative α isoform is a truncated form of the δ isoform.)

(Chen et al., 1998)

Dredd protein has two death effector domains, and a caspase-like domain.

(Inohara et al., 1997)
External Data
Subunit Structure (UniProtKB)

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 15 kDa (caspase-8 subunit p15) and a 10 kDa (caspase-8 subunit p10) subunit (PubMed:9740659). Interacts (via N-terminus) with Diap2; likely to bind Diap2 simultaneously with Fadd to form a trimeric complex (PubMed:10934188, PubMed:22549468).

(UniProt, Q8IRY7)
Post Translational Modification

Polyubiquitinated by Diap2 following activation of the immune deficiency (Imd) pathway.

(UniProt, Q8IRY7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dredd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Voelker et al., 1989)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis stage S10
oocyte
(Chen et al., 1998)
embryonic stage 16
presumptive embryonic/larval central nervous system
(Chen et al., 1998)
adult stageoogenesis stage S10 -- S13
nurse cell
(Chen et al., 1998)
embryonic stage 13
ventral nerve cord
(Chen et al., 1998)
dorsal ridge
(Chen et al., 1998)
embryonic stage 11
embryonic gnathal segment | restricted
(Chen et al., 1998)
embryonic labral segment | restricted
(Chen et al., 1998)
embryonic stage 1 -- 10
organism | ubiquitous
(Chen et al., 1998)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Voelker et al., 1989)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult Malpighian tubule
(McGettigan et al., 2005)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(assigned by UniProt )
(Chen et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dredd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dredd
Transgenic constructs containing regulatory region of Dredd
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
cell shape defective | adult stage | conditional
decreased cell death | adult stage
immune response defective
immune response defective, with Scer\GAL4- :
immune response defective (with Df(1)su(s)R194)
immune response defective (with Df(1)su(s)R194), with Scer\GAL4- :
immune response defective | adult stage
immune response defective | recessive
increased cell death | conditional
increased occurrence of cell division | adult stage
neuroanatomy defective | adult stage
oxidative stress response defective
radiation resistant
short lived | conditional
starvation stress response defective | adult stage, with Scer\GAL4Cg.PA
visible | adult stage, with Scer\GAL4ap-md544
visible | dominant
wild-type
Phenotype manifest in
Allele
adult fat body | nutrition conditional, with Scer\GAL4Cg.PA
intestinal stem cell
macrochaeta | ectopic
mesothoracic tergum
peptidergic neuron | adult stage | ectopic
retina | conditional
rhabdomere | conditional
spermatid
wing, with Scer\GAL4ap-md544
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CASP10
5 of 15
Yes
Yes
Hsap\CASP8
4 of 15
No
Yes
Hsap\CASP9
3 of 15
No
Yes
Hsap\CFLAR
3 of 15
No
Yes
Hsap\CASP1
2 of 15
No
Yes
1  
Hsap\CASP2
2 of 15
No
No
Hsap\CASP3
2 of 15
No
No
7  
Hsap\CASP4
2 of 15
No
No
Hsap\CASP5
2 of 15
No
No
Hsap\CASP14
2 of 15
No
No
Hsap\CARD8
1 of 15
No
Yes
Hsap\CARD16
1 of 15
No
No
Hsap\CARD17
1 of 15
No
No
Hsap\CARD18
1 of 15
No
No
Hsap\CASP6
1 of 15
No
No
Hsap\CASP7
1 of 15
No
No
Hsap\CASP12
1 of 15
No
No
Hsap\CASP16P
1 of 15
No
No
Hsap\PEA15
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Casp8
4 of 15
Yes
Yes
Mmus\Casp9
3 of 15
No
Yes
Mmus\Cflar
3 of 15
No
Yes
Mmus\Casp1
2 of 15
No
No
Mmus\Casp2
2 of 15
No
No
Mmus\Casp3
2 of 15
No
No
Mmus\Casp4
2 of 15
No
No
Mmus\Casp12
2 of 15
No
No
Mmus\Casp14
2 of 15
No
No
Mmus\Casp6
1 of 15
No
No
Mmus\Casp7
1 of 15
No
No
Mmus\Pea15a
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (11)
Rnor\Casp8
4 of 13
Yes
Yes
Rnor\Cflar
3 of 13
No
Yes
Rnor\Casp1
2 of 13
No
No
Rnor\Casp3
2 of 13
No
No
Rnor\Casp4
2 of 13
No
Yes
Rnor\Casp12
2 of 13
No
No
Rnor\Casp14
2 of 13
No
No
Rnor\Casp2
1 of 13
No
No
Rnor\Casp9
1 of 13
No
No
Rnor\LOC103689977
1 of 13
No
No
Rnor\Pea15
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (9)
Xtro\casp10
4 of 12
Yes
Yes
Xtro\casp1
2 of 12
No
No
Xtro\casp9
2 of 12
No
Yes
Xtro\LOC733553
2 of 12
No
No
Xtro\casp2
1 of 12
No
No
Xtro\casp3
1 of 12
No
No
Xtro\casp6
1 of 12
No
No
Xtro\casp7
1 of 12
No
No
Xtro\pea15
1 of 12
No
Yes
Danio rerio (Zebrafish) (23)
Drer\casp10
5 of 15
Yes
Yes
Drer\casp8l1
4 of 15
No
Yes
Drer\casp9
3 of 15
No
Yes
Drer\casp22
3 of 15
No
Yes
Drer\cflara
3 of 15
No
Yes
Drer\casp3a
2 of 15
No
No
Drer\casp3b
2 of 15
No
No
Drer\casp8
2 of 15
No
Yes
Drer\casp20
2 of 15
No
Yes
Drer\casp23
2 of 15
No
No
Drer\caspa
2 of 15
No
No
Drer\caspb
2 of 15
No
No
Drer\caspbl
2 of 15
No
No
Drer\caspxa
2 of 15
No
No
Drer\LOC798445
2 of 15
No
No
Drer\si:ch211-195h23.3
2 of 15
No
Yes
Drer\casp2
1 of 15
No
No
Drer\casp6a
1 of 15
No
No
Drer\casp7
1 of 15
No
No
Drer\casp17
1 of 15
No
No
Drer\casp21
1 of 15
No
No
Drer\pea15
1 of 15
No
Yes
Drer\pycard
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ced-3
3 of 15
Yes
No
1  
Cele\csp-1
2 of 15
No
No
Cele\csp-2
2 of 15
No
No
Cele\csp-3
2 of 15
No
Yes
Cele\ZK795.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907RR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004662
Drosophila simulans
Dsim\Dredd
Drosophila sechellia
Dsec\GM19030
Drosophila erecta
Dere\GG12750
Drosophila yakuba
Dyak\Dredd
Drosophila ananassae
Dana\GF22232
Drosophila pseudoobscura pseudoobscura
Dpse\GA20387
Drosophila persimilis
Dper\GL26745
Drosophila willistoni
Dwil\GK16170
Drosophila virilis
Dvir\GJ16702
Drosophila mojavensis
Dmoj\GI21675
Drosophila grimshawi
Dgri\GH24782
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508GV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17027448
Glossina morsitans
Tsetse fly
Gmor\GMOY007083
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04277
Mayetiola destructor
Hessian fly
Mdes\Mdes008004
Anopheles darlingi
American malaria mosquito
Adar\ADAC003947
Anopheles gambiae
Malaria mosquito
Agam\CASPL1
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014995
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W040T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008021
Bombyx mori
Silkmoth
Bmor\BGIBMGA006726
Danaus plexippus
Monarch butterfly
Dple\DPOGS212093-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005605
Apis florea
Little honeybee
Aflo\4246744548
Apis mellifera
Western honey bee
Amel\GB45352
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21054
Bombus terrestris
Buff-tailed bumblebee
Bter\15211291
Linepithema humile
Argentine ant
Lhum\LH11454
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000c29
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007191
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04021
Tribolium castaneum
Red flour beetle
Tcas\Dredd
Pediculus humanus
Human body louse
Phum\PHUM574530
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13406
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03XG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW003039
Ixodes scapularis
Black-legged tick
Isca\ISCW022545
Ixodes scapularis
Black-legged tick
Isca\ISCW001741
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_198557
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_7107
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300681
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0606 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cspe9L1c
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dcp-1
3 of 10
Decay
3 of 10
Drice
3 of 10
Dronc
3 of 10
Damm
2 of 10
Strica
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 7 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CASP10; caspase 10
    5 of 15
    601762
    CASP8; caspase 8
    4 of 15
    601763
    CASP9; caspase 9
    3 of 15
    602234
        CFLAR; CASP8 and FADD like apoptosis regulator
        3 of 15
        603599
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Dredd
            enzymatic study, western blot, anti tag coimmunoprecipitation, anti tag western blot
            (Kim et al., 2014, Meinander et al., 2012)
            Dredd - Act5C
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - BacA\p35
            anti tag coimmunoprecipitation, anti tag western blot
            (Guntermann and Foley, 2011)
            Dredd - CCT6
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - CG9626
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - Cp190
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - Dark
            anti tag coimmunoprecipitation, anti tag western blot
            (Hu and Yang, 2000)
            Dredd - Diap2
            anti tag coimmunoprecipitation, anti tag western blot, pull down
            (Guntermann et al., 2015, Meinander et al., 2012, Guntermann and Foley, 2011)
            Dredd - Fadd
            anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
            (Fukuyama et al., 2012, Meinander et al., 2012, Guntermann and Foley, 2011, Horng and Medzhitov, 2001, Hu and Yang, 2000)
            Dredd - Hsc70-1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - Hsc70-3
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - Nup358
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - RanGAP
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - Rel
            enzymatic study, western blot
            (Kim et al., 2014, Ertürk-Hasdemir et al., 2009)
            Dredd - RpL12
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - RpL22
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - RpS28b
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - SERCA
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - Sod1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - dnr1
            anti tag coimmunoprecipitation, anti tag western blot
            (Guntermann et al., 2009)
            Dredd - imd
            enzymatic study, western blot
            (Kim et al., 2014)
            Dredd - pzg
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Dredd - βTub56D
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Dredd
            suppressible
            CecA1
            (Ryu et al., 2006)
            Dredd
            enhanceable
            Rel
            (Ayyar et al., 2007)
            Dredd
            enhanceable
            Tollo
            (Ayyar et al., 2007)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Diap1
            enhanceable
            Dredd
            (Leulier et al., 2006)
            Dronc
            suppressible
            Dredd
            (Lee et al., 2011)
            norpA
            suppressible
            Dredd
            (Chinchore et al., 2012)
            PGRP-LF
            suppressible
            Dredd
            (Maillet et al., 2008)
            Rel
            enhanceable
            Dredd
            (Ayyar et al., 2007)
            rpr
            suppressible
            Dredd
            (Di Fruscio et al., 2003)
            RYBP
            suppressible
            Dredd
            (González and Busturia, 2009)
            Tollo
            enhanceable
            Dredd
            (Ayyar et al., 2007)
            External Data
            Subunit Structure (UniProtKB)
            Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 15 kDa (caspase-8 subunit p15) and a 10 kDa (caspase-8 subunit p10) subunit (PubMed:9740659). Interacts (via N-terminus) with Diap2; likely to bind Diap2 simultaneously with Fadd to form a trimeric complex (PubMed:10934188, PubMed:22549468).
            (UniProt, Q8IRY7 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Imd Signaling Pathway Core Components -
            The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
            Metabolic Pathways
            External Data
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map

            1-0

            Cytogenetic map
            1B12-1B13
            Sequence location
            X:633,622..635,545 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            1B12-1B13
            Limits computationally determined from genome sequence between P{EP}svrEP356&P{EP}argEP452 and P{EP}DreddEP1412&P{EP}Suv4-20EP1216a
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            1B10-1B10
            (Inohara, 1997.10.28)
            1B13-1B13
            (Chen, 1997.6.5)
            Experimentally Determined Recombination Data
            Location

            1-0

            (FlyBase, 2016)

            1-0.0

            (Comeron et al., 2012)

            1-

            (Inohara, 1997.10.28)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (8)
            Genomic Clones (16)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (14)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: Dredd anon-1BCa

              (Rodriguez, 1997.9.8)
              Additional comments

              Changed ‘protein’ to ‘caspase’ in the gene fullname to be more informative and consistent with fullnames of other caspase-encoding genes.

              (Steller et al., 2014.7.9)
              Other Comments

              Dredd is necessary to provide immunity to reactive oxygen species-resistant pathogens.

              (Ryu et al., 2006)

              dsRNA made from templates generated with primers directed against this gene stops cleavage of the Rel protein product in mbn-2 and S2 cells.

              (Kleino et al., 2005)

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              Rel endoproteolysis appears to be carried out by the caspase Dredd.

              (Stoven et al., 2003)

              Mutants show no detectable induction of Dpt, CecA1 and CecA2. Attacin levels are reduced compared to wild type and Drs induction is normal.

              (Lu et al., 2001)

              Mutation in Dredd renders flies highly susceptible to infection by Gram-negative bacteria.

              (Leulier et al., 2000)

              "Gene order: In direction of increasing cytology: RpL36+ l(1)1Bi+ Dredd- su(s)+" was stated as revision.

              (Chen et al., 1998)

              "Gene order: In direction of increasing cytology: RpL36? l(1)1Bi+ Dredd- su(s)+ CG13367? l(1)1Bk?" was stated as revision.

              (Rodriguez, 1997.9.8)

              FlyBase curator comment: Gene order described in this paper is "l(1)1Bi? RpL36+ Dredd- su(s)+ CG13367? l(1)1Bk?". FBrf0098592 subsequently reversed the order of l(1)1Bi and RpL36.

              (Voelker et al., 1989)

              Transcription unit defined during molecular analysis of the su(s) region.

              (Voelker et al., 1989)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 68 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (25)
              Reported As
              Symbol Synonym
              CASP8_DROME
              (Fukuyama et al., 2012)
              CG7486
              (Douglas et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Irving et al., 2001, Benos, 2000.12.13)
              DCP-2
              (Kumar and Doumanis, 2000)
              DCP-2/DREDD
              (Meier et al., 2000, Bergmann et al., 1998)
              DCP2
              (Inohara et al., 1997)
              DREDD
              (Galenza and Foley, 2019, Mussabekova et al., 2017, Costechareyre et al., 2016, Imler, 2014, Kleino and Silverman, 2014, Ayyaz and Jasper, 2013, Ferrandon, 2013, Fukuyama et al., 2013, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Vandenabeele and Bertrand, 2012, Fan and Bergmann, 2010, Paquette et al., 2010, Ertürk-Hasdemir et al., 2009, Silverman et al., 2008, Tsichritzis et al., 2007, Leclerc and Reichhart, 2004, Hoffmann, 2003, Christophides et al., 2002, Manning et al., 2002)
              Dcp-2
              (Richardson and Kumar, 2002)
              Dcp-2/Dredd
              (Brachmann and Cagan, 2003, Tittel and Steller, 2000, Vernooy et al., 2000)
              Dcp2
              (Inohara, 1997.10.28)
              Dedd
              Dredd
              (Maitra et al., 2019, Meltzer et al., 2019, Molaei et al., 2019, Anthoney et al., 2018, Charroux et al., 2018, Goto et al., 2018, Kounatidis and Chtarbanova, 2018, Palmer et al., 2018, Zhai et al., 2018, Christesen et al., 2017, Keita et al., 2017, Kounatidis et al., 2017, Kurz et al., 2017, Tavignot et al., 2017, Transgenic RNAi Project members, 2017-, Alaraby et al., 2016, Eroglu and Derry, 2016, Liu et al., 2016, Mao et al., 2016, Melzer and Broemer, 2016, Reid and O'Brochta, 2016, Denton and Kumar, 2015, Guntermann et al., 2015, Momiuchi et al., 2015, Vedanayagam and Garrigan, 2015, Xia et al., 2015, Keebaugh and Schlenke, 2014, Kim et al., 2014, Myllymäki et al., 2014, Nandi et al., 2014, Steller et al., 2014.7.9, Xu and Cherry, 2014, Aparicio et al., 2013, Denton et al., 2013, Gendrin et al., 2013, Kari et al., 2013, Kingsolver et al., 2013, Lee et al., 2013, Merkling and van Rij, 2013, Yacobi-Sharon et al., 2013, Chen et al., 2012, Eleftherianos and Castillo, 2012, Fukuyama et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Meinander et al., 2012, Vecchio et al., 2012, Karpac et al., 2011, Keller et al., 2011, Kuranaga, 2011, Paredes et al., 2011, Suissa et al., 2011, Valanne et al., 2011, Aymeric et al., 2010, Hill-Burns and Clark, 2010, Kim et al., 2010, Sabin et al., 2010, Amarneh et al., 2009, Bond and Foley, 2009, Cronin et al., 2009, Guntermann et al., 2009, Hill-Burns and Clark, 2009, Luce-Fedrow et al., 2009, Obbard et al., 2009, Aggarwal et al., 2008, Goto et al., 2008, Hou et al., 2008, Lhocine et al., 2008, Maillet et al., 2008, Ryu et al., 2008, Ayyar et al., 2007, Dijkers and O'Farrell, 2007, Haerty et al., 2007, Junion et al., 2007, Kuranaga and Miura, 2007, McCall et al., 2007, Primrose et al., 2007, Sackton et al., 2007, Sevrioukov et al., 2007, Valanne et al., 2007, Waterhouse et al., 2007, Wu et al., 2007, Akira et al., 2006, Bergmann, 2006, Delaney et al., 2006, Jang et al., 2006, Kim et al., 2006, Leulier et al., 2006, Ryu et al., 2006, Gesellchen et al., 2005, Kim et al., 2005, Kornbluth and White, 2005, McGettigan et al., 2005, Sang et al., 2005, Zhou et al., 2005, Li et al., 2002, Voelker et al., 1989)
              Dredd/DCP-2
              (Leulier et al., 2006)
              EG:115C2.9
              (Benos et al., 2001, Benos, 2000.12.13)
              Redd
              anon-1BCa
              dDredd
              (Bangi et al., 2012)
              dcp-2/dredd
              (Vernooy et al., 2000, Bergmann et al., 1999)
              dredd
              (Blanco et al., 2020, Aalto et al., 2019, Shinoda et al., 2019, Hori et al., 2018, Napoletano et al., 2017, Ding et al., 2016, Arya and White, 2015, Kale et al., 2015, Verma and Tapadia, 2015, Fernando et al., 2014, Kuang et al., 2014, Liang et al., 2014, Verma and Tapadia, 2014, Lee et al., 2013, Lee et al., 2013, Nelson et al., 2013, Wang et al., 2013, Chinchore et al., 2012, Wang et al., 2012, Douglas et al., 2011, Lee et al., 2011, Paquette et al., 2010, Radyuk et al., 2010, Avadhanula et al., 2009, Berkey et al., 2009, González and Busturia, 2009, Xu et al., 2009, Zsindely et al., 2009, Joza et al., 2008, Baum et al., 2007, Cocco and Rabinow, 2007, Hallem et al., 2007, Huh et al., 2007, Sevrioukov et al., 2007, Balakireva et al., 2006, Brun et al., 2006, Kondo et al., 2006, Leulier et al., 2006, Park et al., 2004, Leulier et al., 2003, Gorski and Marra, 2002, Moreno et al., 2002, Richardson and Kumar, 2002, Kimbrell and Beutler, 2001, Michel et al., 2001, Naitza et al., 2001, Buszczak and Cooley, 2000, Elrod-Erickson et al., 2000, Kumar and Doumanis, 2000, Lemaitre, 2000.12.20, Leulier et al., 2000, Schneider, 2000, Rodriguez et al., 1999, Chen et al., 1998, Rodriguez et al., 1998)
              Name Synonyms
              Ced-3-like/Nedd2-like protein
              Death caspase-2
              Death related ced-3/Nedd2-like caspase
              (Steller et al., 2014.7.9)
              Death related ced-3/Nedd2-like protein
              Drosophila caspase
              (Inohara et al., 1997)
              caspase
              (Bose et al., 1998)
              death-related ced-3/neural precursor cell expressed developmentally downregulated 2 (NEDD2)-like protein
              (Fukuyama et al., 2013)
              Secondary FlyBase IDs
              • FBgn0013388
              • FBgn0023366
              • FBgn0024454
              • FBtr0070152
              • FBpp0070147
              • FBtr0070153
              • FBpp0070148
              • FBtr0070154
              • FBpp0070149
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (286)