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Gene Dmel\Dredd

General Information
Symbol	Dmel\Dredd	Species	D. melanogaster
Name	Death related ced-3/Nedd2-like protein	Annotation symbol	CG7486
Feature type	protein_coding_gene	FlyBase ID	FBgn0020381
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Dcp-2/Dredd, Dcp-2, EG:115C2.9, Dcp2
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	1B12-1B13	Sequence location	X:527,553..529,760 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Death related ced-3/Nedd2-like protein is referred to in FlyBase by the symbol Dmel\Dredd (CG7486, FBgn0020381). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; apoptotic protease activator activity; endopeptidase activity. There is experimental evidence that it is involved in the biological process: immune response; apoptotic process; peripheral nervous system neuron development; sperm individualization; protein processing; defense response to Gram-negative bacterium; peptidoglycan recognition protein signaling pathway; defense response. 31 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639071_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Dredd. Gene sequence location is X:527553..529760.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Guntermann and Foley, 2011, J. Biol. Chem. 286(35): 30284--30294 Controlled Vocabulary Terms proteolysis protein processing
FB2012_01	References Paredes et al., 2011, Immunity 35(5): 770--779 Sequence features BKN30428 HFA18461
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1B12-1B13   Limits computationally determined from genome sequence between P{EP}svrEP356&P{EP}argEP452 and P{EP}DreddEP1412&P{EP}Suv4-20EP1216a
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1B10-1B10     (Inohara, 1997.10.28) 1B13-1B13     (Chen, 1997.6.5)
Experimentally Determined Recombination Data
Location	1- (Inohara, 1997.10.28)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dredd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone GH10971 appears problematic: unspliced intron Atypical cDNA supported: retained intron (FBrf0104738).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dredd-RD FBtr0114559  NM_057903   1897   488 Dredd-RE FBtr0114560  NM_057901   1915   494 Dredd-RF FBtr0114561  NM_057902   1973   284
Additional Transcript Data & Comments
Reported size (kB)	1.708, 1.694 (longest cDNA) (Chen et al., 1998) 1.7, 1.5 (northern blot) (Voelker et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dredd-PD   FBpp0113051   55.5   488   6.95     NP_477251   AAN09022 Dredd-PE   FBpp0113052   56.2   494   6.95     NP_477249   AAF45533 Dredd-PF   FBpp0113053   32.2   284   7.00     NP_477250   AAN09023
Additional Polypeptide Data & Comments
Reported size (kDa)	494, 488 (aa) (Chen et al., 1998)
Comments	When apoptosis is triggered by the expression of rpr, grim, or W proteins, caspase-like processing of the the α, γ, and δ isoforms of Dredd protein occurs. (It is likely that the putative α isoform is a truncated form of the δ isoform.) (Chen et al., 1998, Chen et al., 1998) Dredd protein has two death effector domains, and a caspase-like domain. (Inohara et al., 1997)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) MEROPS - An information resource for peptidases and the proteins that inhibit them • C14.950
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439704   AE014298 AAF45533   AE014298 AAN09022   AE014298 AAN09023   AF007016 AAC31214   AF031652 AAC15843   AF083894 AAC33117   AF083895 AAC33118   AI109704   AI133919   AI257247   AI402238   AI405366   AQ025449   AY060275 AAL25314   CL528108   CO281024   CO292673   CO302379   EC051574   EC051575   EC052060   EC055115   EC056599   EC063676   EC068752   EC085532   EC245022
UniProtKB/Swiss-Prot	Q8IRY7
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage     (Voelker et al., 1989) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 10   organism | ubiquitous   (Chen et al., 1998) embryonic stage 11   embryonic gnathal segment | restricted   (Chen et al., 1998) embryonic labral segment | restricted   (Chen et al., 1998) embryonic stage 13   ventral nerve cord   (Chen et al., 1998) dorsal ridge   (Chen et al., 1998) embryonic stage 16   presumptive embryonic/larval central nervous system   (Chen et al., 1998) adult stage & oogenesis stage S10   oocyte   (Chen et al., 1998) adult stageoogenesis stage S10 -- S13   nurse cell   (Chen et al., 1998) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Voelker et al., 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020381    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020381 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020381 expression level Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    1498 larva L3 puffstage 7-9    1880 white prepupae new    1620 white prepupae 12hr    1485 white prepupae 24hr    1878 pupae 2d postWPP    1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (586) embryo 02-04hr  (414) embryo 04-06hr  (296) embryo 06-08hr  (595) embryo 08-10hr  (764) embryo 10-12hr  (1010) embryo 12-14hr  (949) embryo 14-16hr  (1024) embryo 16-18hr  (784) embryo 18-20hr  (716) embryo 20-22hr  (828) embryo 22-24hr  (849) larva L1  (1329) larva L2  (1121) larva L3 12hr old  (909) larva L3 puffstage 1-2  (1309) larva L3 puffstage 3-6  (1498) larva L3 puffstage 7-9  (1880) white prepupae new  (1620) white prepupae 12hr  (1485) white prepupae 24hr  (1878) pupae 2d postWPP  (1652) pupae 3d postWPP  (970) pupae 4d postWPP  (797) adult male 01day  (867) adult male 05day  (1036) adult male 30day  (1256) adult female 01day  (1059) adult female 05day  (999) adult female 30day  (1089) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6  1498 larva L3 puffstage 7-9  (1880) white prepupae new  (1620) white prepupae 12hr  1485 white prepupae 24hr  (1878) pupae 2d postWPP  (1652) pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    1498 larva L3 puffstage 7-9    1880 white prepupae new    1620 white prepupae 12hr    1485 white prepupae 24hr    1878 pupae 2d postWPP    1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    1498 larva L3 puffstage 7-9    1880 white prepupae new    1620 white prepupae 12hr    1485 white prepupae 24hr    1878 pupae 2d postWPP    1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020381 expression level Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    1498 larva L3 puffstage 7-9    1880 white prepupae new    1620 white prepupae 12hr    1485 white prepupae 24hr    1878 pupae 2d postWPP    1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (586) embryo 02-04hr  (414) embryo 04-06hr  (296) embryo 06-08hr  (595) embryo 08-10hr  (764) embryo 10-12hr  (1010) embryo 12-14hr  (949) embryo 14-16hr  (1024) embryo 16-18hr  (784) embryo 18-20hr  (716) embryo 20-22hr  (828) embryo 22-24hr  (849) larva L1  (1329) larva L2  (1121) larva L3 12hr old  (909) larva L3 puffstage 1-2  (1309) larva L3 puffstage 3-6  (1498) larva L3 puffstage 7-9  (1880) white prepupae new  (1620) white prepupae 12hr  (1485) white prepupae 24hr  (1878) pupae 2d postWPP  (1652) pupae 3d postWPP  (970) pupae 4d postWPP  (797) adult male 01day  (867) adult male 05day  (1036) adult male 30day  (1256) adult female 01day  (1059) adult female 05day  (999) adult female 30day  (1089) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6  1498 larva L3 puffstage 7-9  1880 white prepupae new  1620 white prepupae 12hr  1485 white prepupae 24hr  1878 pupae 2d postWPP  1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    1498 larva L3 puffstage 7-9    1880 white prepupae new    1620 white prepupae 12hr    1485 white prepupae 24hr    1878 pupae 2d postWPP    1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    586 embryo 02-04hr    414 embryo 04-06hr    296 embryo 06-08hr    595 embryo 08-10hr    764 embryo 10-12hr    1010 embryo 12-14hr    949 embryo 14-16hr    1024 embryo 16-18hr    784 embryo 18-20hr    716 embryo 20-22hr    828 embryo 22-24hr    849 larva L1    1329 larva L2    1121 larva L3 12hr old    909 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    1498 larva L3 puffstage 7-9    1880 white prepupae new    1620 white prepupae 12hr    1485 white prepupae 24hr    1878 pupae 2d postWPP    1652 pupae 3d postWPP    970 pupae 4d postWPP    797 adult male 01day    867 adult male 05day    1036 adult male 30day    1256 adult female 01day    1059 adult female 05day    999 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020381    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020381 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020381 expression level Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020381 expression level Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.25 Larval Midgut    117.4 Larval Hindgut    180.1 Larval Malpighian Tubules    189.2 Larval Fat Body    191.8 Larval Salivary Gland    297.3 Larval Trachea    219.5 Larval Carcass    120.375 Adult Head    92.7 Adult Eye    109.3 Adult Brain    63.5 Adult Thoracic-Abdominal Ganglion    82.5 Adult Crop    202.7 Adult Midgut    170.7 Adult Hindgut    217.9 Adult Malpighian Tubules    170.2 Adult Fat Body    164.8 Adult Salivary Gland    235 Adult Heart    152.3 Adult VirginFemale Spermatheca    210.8 Adult InseminatedFemale Spermatheca    238.2 Adult Ovary    91 Adult Testis    54 Adult Male Accessory Gland    251.8 Adult Carcass    140.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    92.7   NA  Eye    109.3   NA  Brain    63.5   111.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    82.5   NA  Crop    202.7   117.4  Midgut    170.7   180.1  Hindgut    217.9   189.2  Malpighian Tubules    170.2   191.8  Fat Body    164.8   297.3  Salivary Gland    235   NA  Heart    152.3   219.5  Trachea    NA   NA  VirginFemale Spermatheca    210.8   NA  InseminatedFemale Spermatheca    238.2   NA  Ovary    91   NA  Testis    54   NA  Male Accessory Gland    251.8   120.375  Carcass    140.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020381 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7486-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable DreddB118 DreddD44 DreddD55 DreddEY08404 DreddF64 DreddL23 viable, with Scer\GAL4pnr-MD237 DreddGD12252 Sterility Allele fertile DreddEY08404 Other Phenotypes Allele immune response defective DreddB118 DreddEP1412 Dreddunspecified immune response defective, with Scer\GAL4[-]: DreddEP1412 immune response defective (with Df(1)su(s)R194), with Scer\GAL4[-]: DreddEP1412 radiation resistant DreddD55 visible | dominant DreddEP1412 wild-type Dredd+tCa Phenotype manifest in Allele macrochaeta | ectopic DreddEP1412 mesothoracic tergum DreddEP1412 spermatid DreddB118
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Dredd Class Mutagen Stocks Known lesion DreddEP1412 hypomorphic allele - genetic evidence P-element activity 1 Yes DreddEY08404 P-element activity 1 -- DreddB118 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes DreddD44 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes DreddD55 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes DreddF64 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes DreddL23 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes DreddD3 P-element activity 0 Yes Dreddunspecified 0 --
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dredd Class Mutagen Stocks Known lesion DreddGD12252 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DreddHMS00063 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DreddKK110428 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dredd+tCa in vitro construct - genomic fragment 0 Yes DreddAct5C.T:SV5\V5 in vitro construct - coding region fusion 0 Yes DreddC:A.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes DredddsRNA.cMa in vitro construct - RNAi 0 Yes DredddsRNA.cPa in vitro construct - RNAi 0 Yes DredddsRNA.cZa in vitro construct - RNAi 0 Yes DredddsRNA.Scer\UAS.cLa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Dreddhs.PH in vitro construct 0 Yes DreddMtnA.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes DreddScer\UAS.cVa 0 Yes DreddScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dreddα.MtnA.T:Zzzz\FLAG,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dreddα.MtnA in vitro construct - regulatory fusion 0 Yes Dreddα.Δ1-120.MtnA.T:Zzzz\FLAG,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dreddβ.MtnA in vitro construct - regulatory fusion 0 Yes Dreddγ.MtnA.T:Uuuu\T7,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dreddγ.MtnA in vitro construct - regulatory fusion 0 Yes Dreddδ.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dreddδ.MtnA.T:Uuuu\T7,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)DreddD3 (Leulier et al., 2000) Df(1)su(s)R194 (Elrod-Erickson et al., 2000, Leulier et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12252} NA P{KK110428} NA P{TRiP.HMS00063} NA P{UAS-Dredd.V} NA reporter construct P{Dredd-lacZ.L} No characterization construct P{Dredd+.C} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DreddEP1412 NA P{EPgy2}DreddEY08404 NA miscellaneous insertions P{SUPor-P}su(s)KG05922 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
apoptotic protease activator activity inferred from mutant phenotype (assigned by UniProtKB) (Chen et al., 1998) endopeptidase activity inferred from direct assay (Ertürk-Hasdemir et al., 2009) protein binding inferred from physical interaction with BG4 (Hu and Yang, 2000) inferred from physical interaction with Rel (assigned by UniProtKB) (Leulier et al., 2000)
Biological Process
CV term Evidence References
apoptotic process inferred from expression pattern AND inferred from genetic interaction with rpr (assigned by UniProtKB) (Chen et al., 1998) defense response inferred from mutant phenotype (Elrod-Erickson et al., 2000) defense response to Gram-negative bacterium inferred from mutant phenotype (assigned by UniProtKB) (Leulier et al., 2000) immune response inferred from mutant phenotype (Ryu et al., 2006) peptidoglycan recognition protein signaling pathway inferred from mutant phenotype (Leulier et al., 2000) peripheral nervous system neuron development inferred from mutant phenotype (Ayyar et al., 2007) protein processing inferred from direct assay (Ertürk-Hasdemir et al., 2009) sperm individualization inferred from mutant phenotype (Huh et al., 2004)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Chen et al., 1998)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with human CASP10 AND inferred from sequence or structural similarity with human CASP8 (assigned by UniProtKB) (Chen et al., 1998) non-traceable author statement (Chen, 1997.6.5, Inohara, 1997.10.28, Lemaitre, 2000.12.20) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Brachmann and Cagan, 2003, Tittel and Steller, 2000, Abrams, 1999)
Biological Process
CV term Evidence References
apoptotic process non-traceable author statement (Chen, 1997.6.5, Lawen, 2003) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Kimbrell and Beutler, 2001) defense response to Gram-negative bacterium traceable author statement (Leclerc and Reichhart, 2004) immune response traceable author statement (Kimbrell and Beutler, 2001) innate immune response traceable author statement (Kumar and Doumanis, 2000) positive regulation of antibacterial peptide biosynthetic process non-traceable author statement (Lemaitre, 2000.12.20) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002) proteolysis inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR002398, InterPro:IPR011600 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dredd allele Gene References unspecified CecA1 (Ryu et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57579 DroID - A comprehensive database of gene and protein interactions. • FBgn0020381 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31011
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22232 Dere\GG12750 Dgri\GH24782 Dmoj\GI21675 Dper\GL26745 Dpse\GA20387 Dsec\GM19030 Dsim\Dredd Dvir\GJ16702 Dwil\GK16170 Dyak\Dredd
Curated drosophilid orthologs	Dpse\GA20387   Dsim\Dredd   Dyak\Dredd
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014148-PA Aedes aegypti (mosquito) AGAP011693-PA Anopheles gambiae (mosquito) XP_001120830.1 Apis mellifera (honey bee) 194931 Branchiostoma floridae (lancelet) BGIBMGA006726-PA Bombyx mori (silk worm) CBP35208 Caenorhabditis briggsae (nematode) CE28270 Caenorhabditis elegans (worm) CPIJ014995 Culex pipens (mosquito) ENSCPOP00000008633 Cavia porcellus (guinea pig) 225308 Daphnia pulex (daphnia) ENSP00000351273 Homo sapiens (human) ENSMMUP00000037892 Macaca mulatta (rhesus monkey) PHUM003209-PA Pediculus humanus (human body louse) ENSPTRP00000021879 Pan troglodytes (chimpanzee) XP_972371.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV25478 LH11454 FBgn0067449 FBgn0218172 FBgn0203883 FBgn0067524 FBgn0173933 JGI_V11_225308 JGI_V11_45861 FBgn0080382 FBgn0164326 FBgn0144405 FBgn0132237 FBgn0105037 FBgn0099230 CPIJ014995 BGIBMGA008021 BGIBMGA006726 GB30331 GB17683 GB16425 CASPL1 PB21427 PHUM574530 GLEAN_14026
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10456 P{EP}DreddEP1412 w1118 16892 y1 P{EPgy2}DreddEY08404 w67c23 34070 y1 sc* v1; P{TRiP.HMS00063}attP2
VDRC	v104726 P{KK110428}VIE-260B v28041 w1118; P{GD12252}v28041/CyO
Genomic Clones ( 1 )
	BACR16G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10971
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08960 GH25343 LP05556
Other clones	37550 55990 72482 CK01.14B.G11 EC051574 EC051575 EC052060 EC055115 EC056599 EK155746 EK184030 EK200730
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020381 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31011
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dredd anon-1BCa (Rodriguez, 1997.9.8)
Additional comments
Other Comments
	Dredd is necessary to provide immunity to reactive oxygen species-resistant pathogens. (Ryu et al., 2006) dsRNA made from templates generated with primers directed against this gene stops cleavage of the Rel protein product in mbn-2 and S2 cells. (Kleino et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Rel endoproteolysis appears to be carried out by the caspase Dredd. (Stoven et al., 2003) Mutants show no detectable induction of Dpt, CecA1 and CecA2. Attacin levels are reduced compared to wild type and Drs induction is normal. (Lu et al., 2001) Mutation in Dredd renders flies highly susceptible to infection by Gram-negative bacteria. (Leulier et al., 2000) "Gene order: In direction of increasing cytology: RpL36+ l(1)1Bi+ Dredd- su(s)+" was stated as revision. (Chen et al., 1998) "Gene order: In direction of increasing cytology: RpL36? l(1)1Bi+ Dredd- su(s)+ CG13367? l(1)1Bk?" was stated as revision. (Rodriguez, 1997.9.8) FlyBase curator comment: Gene order described in this paper is "l(1)1Bi? RpL36+ Dredd- su(s)+ CG13367? l(1)1Bk?". FBrf0098592 subsequently reversed the order of l(1)1Bi and RpL36. (Voelker et al., 1989) Transcription unit defined during molecular analysis of the su(s) region. (Voelker et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057901 NM_057902 NM_057903 RefSeq (Proteins) • NP_477249 NP_477250 NP_477251 DDBJ / EMBL / GenBank • AA439704 AAC15843 AAC31214 AAC33117 AAC33118 AAF45533 AAF45533.2 AAL25314 AAN09022 AAN09022.1 AAN09023 AAN09023.1 AF007016 AF031652 AF083894 AF083895 AI133919 AI402238 AL031581 AQ025449 AY060275 CL528108 Entrez Gene - A searchable database of RefSeq genes. • 31011 UniProtKB/Swiss-Prot • Q8IRY7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) MEROPS - An information resource for peptidases and the proteins that inhibit them • C14.950
Linkouts
	BioGRID - A database of protein and genetic interactions • 57579 DroID - A comprehensive database of gene and protein interactions. • FBgn0020381 DRSC - Results from RNAi screens. • FBgn0020381 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020381 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7486-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020381 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 148668 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31011 InParanoid A subset of ortholog calls from InParanoid. • AAEL014148-PA Aedes aegypti (mosquito) AGAP011693-PA Anopheles gambiae (mosquito) XP_001120830.1 Apis mellifera (honey bee) 194931 Branchiostoma floridae (lancelet) BGIBMGA006726-PA Bombyx mori (silk worm) CBP35208 Caenorhabditis briggsae (nematode) CE28270 Caenorhabditis elegans (worm) CPIJ014995 Culex pipens (mosquito) ENSCPOP00000008633 Cavia porcellus (guinea pig) 225308 Daphnia pulex (daphnia) ENSP00000351273 Homo sapiens (human) ENSMMUP00000037892 Macaca mulatta (rhesus monkey) PHUM003209-PA Pediculus humanus (human body louse) ENSPTRP00000021879 Pan troglodytes (chimpanzee) XP_972371.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/dredd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31011 modMine - Data generated by the modENCODE project. • FBgn0020381 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV25478 LH11454 FBgn0067449 FBgn0218172 FBgn0203883 FBgn0067524 FBgn0173933 JGI_V11_225308 JGI_V11_45861 FBgn0080382 FBgn0164326 FBgn0144405 FBgn0132237 FBgn0105037 FBgn0099230 CPIJ014995 BGIBMGA008021 BGIBMGA006726 GB30331 GB17683 GB16425 CASPL1 PB21427 PHUM574530 GLEAN_14026
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	anon-1BCa   CG7486 (Irving et al., 2001, Benos, 2000.12.13, Keleman et al., 2009.8.5, Douglas et al., 2011, Ni et al., 2011.7.19) Dcp-2 (Richardson and Kumar, 2002, ) DCP-2 (Kumar and Doumanis, 2000) Dcp2 (Inohara, 1997.10.28, ) DCP2 (Inohara et al., 1997) Dcp-2/Dredd (Tittel and Steller, 2000, Brachmann and Cagan, 2003, Vernooy et al., 2000) DCP-2/DREDD (Meier et al., 2000, Bergmann et al., 1998) dcp-2/dredd (Vernooy et al., 2000, Bergmann et al., 1999) Dedd   Dredd (Guntermann et al., 2009, Zhou et al., 2005, McCall et al., 2007, Voelker et al., 1989, Akira et al., 2006, Delaney et al., 2006, Ryu et al., 2006, Bergmann, 2006, Kim et al., 2006, Jang et al., 2006, Ayyar et al., 2007, Waterhouse et al., 2007, McGettigan et al., 2005, Kuranaga and Miura, 2007, Li et al., 2002, Sevrioukov et al., 2007, Kornbluth and White, 2005, Goto et al., 2008, Leulier et al., 2006, Haerty et al., 2007, Ryu et al., 2008, Dijkers and O'Farrell, 2007, Lhocine et al., 2008, Junion et al., 2007, Primrose et al., 2007, Wu et al., 2007, Amarneh et al., 2009, Gesellchen et al., 2005, Cronin et al., 2009, Sackton et al., 2007, Sang et al., 2005, Hill-Burns and Clark, 2009, Aggarwal et al., 2008, Obbard et al., 2009, Kim et al., 2005, Aymeric et al., 2010, Suissa et al., 2011) DREDD (Manning et al., 2002, Leclerc and Reichhart, 2004, Hoffmann, 2003, Silverman et al., 2008, Christophides et al., 2002, Tsichritzis et al., 2007, Ertürk-Hasdemir et al., 2009, Paquette et al., 2010, Fan and Bergmann, 2010) dredd (Park et al., 2004, Kimbrell and Beutler, 2001, Schneider, 2000, Moreno et al., 2002, Richardson and Kumar, 2002, Gorski and Marra, 2002, Michel et al., 2001, Naitza et al., 2001, Kumar and Doumanis, 2000, Lemaitre, 2000.12.20, Leulier et al., 2000, Buszczak and Cooley, 2000, Elrod-Erickson et al., 2000, Rodriguez et al., 1999, Chen et al., 1998, Rodriguez et al., 1998, Baum et al., 2007, Cocco and Rabinow, 2007, Huh et al., 2007, Sevrioukov et al., 2007, Joza et al., 2008, Kondo et al., 2006, Hallem et al., 2007, Leulier et al., 2006, Brun et al., 2006, Leulier et al., 2003, Berkey et al., 2009, Paquette et al., 2010, Zsindely et al., 2009, Radyuk et al., 2010, Lee et al., 2011, Douglas et al., 2011) Dredd/DCP-2 (Leulier et al., 2006) EG:115C2.9 (Benos et al., 2001, Benos, 2000.12.13, ) Redd   unnamed (Voelker et al., 1990)
Name Synonym	caspase (Bose et al., 1998, Radyuk et al., 2010) Ced-3-like/Nedd2-like protein   Death caspase-2   Death related ced-3/Nedd2-like protein   Drosophila caspase (Inohara et al., 1997)
Secondary FlyBase IDs
	FBgn0013388 FBgn0023366 FBgn0024454 FBpp0070147 FBpp0070148 FBpp0070149 FBtr0070152 FBtr0070153 FBtr0070154
References ( 167 )
Generate a list of	All references relating to this gene ( 167 )
List References by type	Research paper  ( 90 ) Supplementary material  ( 8 ) Review  ( 41 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 9 )
	Douglas et al., 2011, Proc. Biol. Sci. 278(1704): 333--338 How the insect immune system interacts with an obligate symbiotic bacterium. [FBrf0212672] Guntermann and Foley, 2011, J. Biol. Chem. 286(35): 30284--30294 The Protein Dredd Is an Essential Component of the c-Jun N-terminal Kinase Pathway in the Drosophila Immune Response. [FBrf0214801] Lee et al., 2011, J. Comp. Neurol. 519(1): 34--48 Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. [FBrf0212368] Paredes et al., 2011, Immunity 35(5): 770--779 Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection. [FBrf0216727] Suissa et al., 2011, J. Biol. Chem. 286(17): 15556--15564 The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. [FBrf0213516] Aymeric et al., 2010, Molec. Immunol. 47(14): 2342--2348 Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens. [FBrf0211463] Fan and Bergmann, 2010, Cell Death Differ. 17(3): 534--539 The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. [FBrf0209949] Paquette et al., 2010, Mol. Cell 37(2): 172--182 Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-kappaB Signaling. [FBrf0209837] Radyuk et al., 2010, Biochim. biophys. Acta 1800(11): 1153--1163 Peroxiredoxin 5 modulates immune response in Drosophila. [FBrf0211669] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...