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Gene Dmel\Pcaf

General Information
Symbol	Dmel\Pcaf	Species	D. melanogaster
Name	Pcaf	Annotation symbol	CG4107
Feature type	protein_coding_gene	FlyBase ID	FBgn0020388
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	GCN5, dGCN5, dmGCN5, P/CAF, Gcn5/PCAF, dKAT2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69C4-69C4	Sequence location	3L:12,514,229..12,517,114 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pcaf is referred to in FlyBase by the symbol Dmel\Pcaf (CG4107, FBgn0020388). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; chromatin binding. There is experimental evidence that it is involved in the biological process: histone H3 acetylation; dendrite morphogenesis; histone H4 acetylation; muscle organ development; axon target recognition. 20 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; external compound sense organ; thoracic segment; adult; appendage segment; peripheral nervous system; eo support cell; imaginal precursor. It has one annotated transcript and one annotated polypeptide. Protein features are: Acyl-CoA N-acyltransferase; Bromodomain; Bromodomain, conserved site; GCN5-related N-acetyltransferase (GNAT) domain; Histone acetylase PCAF; PCAF, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval midgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627246_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pcaf. Gene sequence location is 3L:12514229..12517114.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Kirilly et al., 2011, Neuron 72(1): 86--100 Sequence features HFA11248 BKN22042 Controlled Vocabulary Terms nucleus chromatin binding histone acetyltransferase complex
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69C4-69C4   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References 69C8-69C12     (Smith, 1997.10.14) 69C8-69C12   (determined by in situ hybridisation)   (Smith et al., 1998) 69C8-69C12   (determined by in situ hybridisation)   (Smith et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pcaf for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pcaf-RA FBtr0075969  NM_140329   2770   813
Additional Transcript Data & Comments
Reported size (kB)	2.8 (northern blot) (Smith et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pcaf-PA   FBpp0075701   92.2   813   9.15     NP_648586   AAF49904
Additional Polypeptide Data & Comments
Reported size (kDa)	813 (aa); 998 (kD observed); 93 (kD predicted) (Smith et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain, conserved site (IPR018359) GCN5-related N-acetyltransferase (GNAT) domain (IPR000182) Bromodomain (IPR001487) PCAF, N-terminal (IPR009464) Acyl-CoA N-acyltransferase (IPR016181) Histone acetylase PCAF (IPR016376)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201588   AA202950   AA246431   AA246559   AA246713   AA263838   AA391484   AA392076   AA536486   AA536552   AA536592   AA538914   AA538935   AA539663   AA540018   AA540193   AA540999   AA567259   AA695025   AA735095   AA735952   AA817017   AA941701   AA942144   AA948792   AA951240   AA951264   AA951434   AA952010   AA978585   AA990859   AE014296 AAF49904   AF029776 AAC39102   AI134208   AI292458   AI295627   AI456262   AI456789   AI456802   AI512635   AI514970   AI515783   AI519268   AI519914   AI519932   AI520300   AI531434   AI533473   AI543875   AI546086   AW940418   AX260127   AY069097 AAL39242   BI162247   BI165916   BI167924   BI167930   BI240149   BI366084   BI367335   BI375061   BI482707   BI484317   BI577651   BI578518   BI579518   BI608902   BI609644   BI627237   BI638999   CA804023   CA806062   CA806870   CA807446   CA807744   CO271414   CO275066   CO275731   CO279491   CO282368   CO296885   CO302080   CO313933   CZ485384   CZ488035   CZ488036   EC059906   EC071586   EC083657   EC195331   EC197486   EC199539   EC201213   EC211375   EC214101   EC247688   EC248618   GH787223   GH795904   GH938190
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76216 Q9VTZ1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Smith et al., 1998)
Additional Descriptive Data
	Pcaf transcripts are detected throughout development on northern blots with the highest levels in early embryos and late larvae. (Smith et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020388    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020388 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020388 expression level Developmental Stage   Expression Level embryo 00-02hr    3695 embryo 02-04hr    4267 embryo 04-06hr    3880 embryo 06-08hr    3746 embryo 08-10hr    3356 embryo 10-12hr    3368 embryo 12-14hr    1864 embryo 14-16hr    2370 embryo 16-18hr    1693 embryo 18-20hr    1095 embryo 20-22hr    2532 embryo 22-24hr    1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr    1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day    1736 adult female 30day    1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3695) embryo 02-04hr  (4267) embryo 04-06hr  (3880) embryo 06-08hr  (3746) embryo 08-10hr  (3356) embryo 10-12hr  (3368) embryo 12-14hr  (1864) embryo 14-16hr  (2370) embryo 16-18hr  (1693) embryo 18-20hr  (1095) embryo 20-22hr  (2532) embryo 22-24hr  (1993) larva L1  (732) larva L2  (655) larva L3 12hr old  (568) larva L3 puffstage 1-2  (899) larva L3 puffstage 3-6  (1154) larva L3 puffstage 7-9  (1092) white prepupae new  (1012) white prepupae 12hr  (1309) white prepupae 24hr  (1545) pupae 2d postWPP  (1036) pupae 3d postWPP  (558) pupae 4d postWPP  (472) adult male 01day  (878) adult male 05day  (978) adult male 30day  (1016) adult female 01day  (1188) adult female 05day  (1736) adult female 30day  (1932) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3695) embryo 02-04hr  (4267) embryo 04-06hr  (3880) embryo 06-08hr  (3746) embryo 08-10hr  (3356) embryo 10-12hr  (3368) embryo 12-14hr  (1864) embryo 14-16hr  (2370) embryo 16-18hr  (1693) embryo 18-20hr    1095 embryo 20-22hr  (2532) embryo 22-24hr  (1993) larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr  (1545) pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day  (1736) adult female 30day  (1932) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3695 embryo 02-04hr    4267 embryo 04-06hr    3880 embryo 06-08hr    3746 embryo 08-10hr    3356 embryo 10-12hr    3368 embryo 12-14hr    1864 embryo 14-16hr    2370 embryo 16-18hr    1693 embryo 18-20hr    1095 embryo 20-22hr    2532 embryo 22-24hr    1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr    1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day    1736 adult female 30day    1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3695 embryo 02-04hr    4267 embryo 04-06hr    3880 embryo 06-08hr    3746 embryo 08-10hr    3356 embryo 10-12hr    3368 embryo 12-14hr    1864 embryo 14-16hr    2370 embryo 16-18hr    1693 embryo 18-20hr    1095 embryo 20-22hr    2532 embryo 22-24hr    1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr    1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day    1736 adult female 30day    1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020388 expression level Developmental Stage   Expression Level embryo 00-02hr    3695 embryo 02-04hr    4267 embryo 04-06hr    3880 embryo 06-08hr    3746 embryo 08-10hr    3356 embryo 10-12hr    3368 embryo 12-14hr    1864 embryo 14-16hr    2370 embryo 16-18hr    1693 embryo 18-20hr    1095 embryo 20-22hr    2532 embryo 22-24hr    1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr    1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day    1736 adult female 30day    1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3695) embryo 02-04hr  (4267) embryo 04-06hr  (3880) embryo 06-08hr  (3746) embryo 08-10hr  (3356) embryo 10-12hr  (3368) embryo 12-14hr  (1864) embryo 14-16hr  (2370) embryo 16-18hr  (1693) embryo 18-20hr  (1095) embryo 20-22hr  (2532) embryo 22-24hr  (1993) larva L1  (732) larva L2  (655) larva L3 12hr old  (568) larva L3 puffstage 1-2  (899) larva L3 puffstage 3-6  (1154) larva L3 puffstage 7-9  (1092) white prepupae new  (1012) white prepupae 12hr  (1309) white prepupae 24hr  (1545) pupae 2d postWPP  (1036) pupae 3d postWPP  (558) pupae 4d postWPP  (472) adult male 01day  (878) adult male 05day  (978) adult male 30day  (1016) adult female 01day  (1188) adult female 05day  (1736) adult female 30day  (1932) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3695) embryo 02-04hr  (4267) embryo 04-06hr  (3880) embryo 06-08hr  (3746) embryo 08-10hr  (3356) embryo 10-12hr  (3368) embryo 12-14hr  1864 embryo 14-16hr  2370 embryo 16-18hr  1693 embryo 18-20hr    1095 embryo 20-22hr  (2532) embryo 22-24hr  1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr  1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day  1736 adult female 30day  1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3695 embryo 02-04hr    4267 embryo 04-06hr    3880 embryo 06-08hr    3746 embryo 08-10hr    3356 embryo 10-12hr    3368 embryo 12-14hr    1864 embryo 14-16hr    2370 embryo 16-18hr    1693 embryo 18-20hr    1095 embryo 20-22hr    2532 embryo 22-24hr    1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr    1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day    1736 adult female 30day    1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3695 embryo 02-04hr    4267 embryo 04-06hr    3880 embryo 06-08hr    3746 embryo 08-10hr    3356 embryo 10-12hr    3368 embryo 12-14hr    1864 embryo 14-16hr    2370 embryo 16-18hr    1693 embryo 18-20hr    1095 embryo 20-22hr    2532 embryo 22-24hr    1993 larva L1    732 larva L2    655 larva L3 12hr old    568 larva L3 puffstage 1-2    899 larva L3 puffstage 3-6    1154 larva L3 puffstage 7-9    1092 white prepupae new    1012 white prepupae 12hr    1309 white prepupae 24hr    1545 pupae 2d postWPP    1036 pupae 3d postWPP    558 pupae 4d postWPP    472 adult male 01day    878 adult male 05day    978 adult male 30day    1016 adult female 01day    1188 adult female 05day    1736 adult female 30day    1932 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020388    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020388 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval midgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020388 expression level Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020388 expression level Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    193.475 Larval Midgut    122.5 Larval Hindgut    98.3 Larval Malpighian Tubules    164.1 Larval Fat Body    118.4 Larval Salivary Gland    90.9 Larval Trachea    127.7 Larval Carcass    96.25 Adult Head    98.9 Adult Eye    70.05 Adult Brain    129.5 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    106.6 Adult Midgut    98.8 Adult Hindgut    99.4 Adult Malpighian Tubules    126.1 Adult Fat Body    162.6 Adult Salivary Gland    62.8 Adult Heart    119.3 Adult VirginFemale Spermatheca    242.9 Adult InseminatedFemale Spermatheca    242.6 Adult Ovary    244.7 Adult Testis    29 Adult Male Accessory Gland    112.7 Adult Carcass    121.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    98.9   NA  Eye    70.05   NA  Brain    129.5   193.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    127.4   NA  Crop    106.6   122.5  Midgut    98.8   98.3  Hindgut    99.4   164.1  Malpighian Tubules    126.1   118.4  Fat Body    162.6   90.9  Salivary Gland    62.8   NA  Heart    119.3   127.7  Trachea    NA   NA  VirginFemale Spermatheca    242.9   NA  InseminatedFemale Spermatheca    242.6   NA  Ovary    244.7   NA  Testis    29   NA  Male Accessory Gland    112.7   96.25  Carcass    121.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020388 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4107-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pcaf Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3L)sex204) PcafC137T PcafE333st PcafQ186st PcafΔT280-F285 lethal | prepupal stage (with PcafE333st) PcafQ186st lethal | prepupal stage (with PcafQ186st) PcafE333st lethal | prepupal stage | recessive PcafE333st lethal | recessive PcafQ186st PcafΔT280-F285 semi-lethal | pharate adult stage (with PcafC137T) PcafE333st semi-lethal | pharate adult stage (with PcafE333st) PcafC137T PcafΔT280-F285 semi-lethal | pharate adult stage (with PcafΔT280-F285) PcafE333st viable, with Scer\GAL4pnr-MD237 PcafGD11218 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 PcafGD11218 Phenotype manifest in Allele adult cuticle & adult abdomen (with PcafC137T) PcafE333st adult cuticle & adult abdomen (with PcafE333st) PcafΔT280-F285 PcafC137T adult cuticle & adult abdomen (with PcafΔT280-F285) PcafE333st cuticle & abdomen & pharate adult, with Scer\GAL4esg-NP5153 PcafdsRNA.Scer\UAS cuticle & abdomen & pharate adult (with PcafC137T) PcafE333st cuticle & abdomen & pharate adult (with PcafE333st) PcafΔT280-F285 PcafC137T cuticle & abdomen & pharate adult (with PcafΔT280-F285) PcafE333st eye, with Df(3L)sex204/PcafE333st, Scer\GAL4da.G32 PcafΔPcaf.Scer\UAS eye (with Df(3L)sex204), with PcafΔPcaf.Scer\UAS, Scer\GAL4da.G32 PcafE333st eye (with PcafC137T) PcafE333st eye (with PcafE333st) PcafΔT280-F285 PcafC137T eye (with PcafΔT280-F285) PcafE333st eye photoreceptor cell PcafE333st femur, with Df(3L)sex204/PcafE333st, Scer\GAL4da.G32 PcafΔPcaf.Scer\UAS femur (with Df(3L)sex204), with PcafΔPcaf.Scer\UAS, Scer\GAL4da.G32 PcafE333st imaginal disc PcafE333st metathoracic leg (with PcafC137T) PcafE333st metathoracic leg (with PcafE333st) PcafΔT280-F285 PcafC137T metathoracic leg (with PcafΔT280-F285) PcafE333st metathoracic leg | pharate adult stage (with PcafC137T) PcafE333st metathoracic leg | pharate adult stage (with PcafE333st) PcafΔT280-F285 PcafC137T metathoracic leg | pharate adult stage (with PcafΔT280-F285) PcafE333st ommatidium (with PcafC137T) PcafE333st ommatidium (with PcafE333st) PcafΔT280-F285 PcafC137T ommatidium (with PcafΔT280-F285) PcafE333st ovary, with Df(3L)sex204/PcafE333st, Scer\GAL4da.G32 PcafΔBromo.Scer\UAS PcafScer\UAS.cCa ovary (with Df(3L)sex204), with PcafScer\UAS.cCa, Scer\GAL4da.G32 PcafE333st ovary (with Df(3L)sex204), with PcafΔBromo.Scer\UAS, Scer\GAL4da.G32 PcafE333st polytene chromosome puff | wandering third instar larval stage PcafE333st prepupa PcafE333st prepupa (with PcafE333st) PcafQ186st prepupa (with PcafQ186st) PcafE333st stage S5 oocyte, with Df(3L)sex204/PcafE333st, Scer\GAL4da.G32 PcafΔBromo.Scer\UAS PcafScer\UAS.cCa stage S5 oocyte (with Df(3L)sex204), with PcafScer\UAS.cCa, Scer\GAL4da.G32 PcafE333st stage S5 oocyte (with Df(3L)sex204), with PcafΔBromo.Scer\UAS, Scer\GAL4da.G32 PcafE333st stage S6 oocyte, with Df(3L)sex204/PcafE333st, Scer\GAL4da.G32 PcafΔBromo.Scer\UAS PcafScer\UAS.cCa stage S6 oocyte (with Df(3L)sex204), with PcafScer\UAS.cCa, Scer\GAL4da.G32 PcafE333st stage S6 oocyte (with Df(3L)sex204), with PcafΔBromo.Scer\UAS, Scer\GAL4da.G32 PcafE333st tarsal segment, with Scer\GAL4vg.boundary PcafdsRNA.Scer\UAS trichogen cell, with Scer\GAL4pnr-MD237 PcafGD11218 wing, with Df(3L)sex204/PcafE333st, Scer\GAL4da.G32 PcafΔPcaf.Scer\UAS wing (with Df(3L)sex204), with PcafΔPcaf.Scer\UAS, Scer\GAL4da.G32 PcafE333st wing (with PcafC137T) PcafE333st wing (with PcafE333st) PcafΔT280-F285 PcafC137T wing (with PcafΔT280-F285) PcafE333st wing disc | posterior compartment, with Scer\GAL4en-e16E PcafdsRNA.Scer\UAS wing margin, with Scer\GAL4vg.boundary PcafdsRNA.Scer\UAS wing vein | posterior compartment, with Scer\GAL4en-e16E PcafdsRNA.Scer\UAS
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Pcaf Class Mutagen Stocks Known lesion Pcaff02830 piggyBac transposase 2 -- Pcaff05456 piggyBac transposase 2 -- PcafC137T hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes PcafE333st ethyl methanesulfonate 1 Yes PcafMB09741 1 -- PcafQ186st loss of function allele ethyl methanesulfonate 1 Yes PcafΔT280-F285 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Pcafunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pcaf Class Mutagen Stocks Known lesion PcafGD11218 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes PcafdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PcafGL00439 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PcafHMS00941 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pcaf+t4.7 in vitro construct - genomic fragment 0 Yes PcafdsRNA.cRa in vitro construct - RNAi 0 Yes PcafKK101976 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PcafScer\UAS.cCa in vitro construct - coding region fusion 0 Yes PcafΔAda.Scer\UAS in vitro construct - deletion 0 Yes PcafΔBromo.Scer\UAS in vitro construct - deletion 0 Yes PcafΔHAT.Scer\UAS in vitro construct - deletion 0 Yes PcafΔPcaf.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)sex204 (Carre et al., 2005, Carre et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11218} NA P{KK101976} NA P{TRiP.GL00439} NA P{TRiP.HMS00941} NA P{UAS-Pcaf.C} NA P{UAS-Pcaf.dsRNA} NA P{UAS-Pcaf.ΔAda} NA P{UAS-Pcaf.ΔBromo} NA P{UAS-Pcaf.ΔHAT} NA P{UAS-Pcaf.ΔPcaf} NA characterization construct P{PL} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Pcaff02830 NA PBac{WH}Pcaff05456 NA insertion of enhancer trap binary system Mi{ET1}PcafMB09741 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Guelman et al., 2006) H3 histone acetyltransferase activity inferred from direct assay (Suganuma et al., 2008) H4 histone acetyltransferase activity inferred from direct assay (Suganuma et al., 2008)
Biological Process
CV term Evidence References
axon target recognition inferred from mutant phenotype (Weake et al., 2008) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) histone H3 acetylation inferred from direct assay (Suganuma et al., 2008, Guelman et al., 2006) histone H4 acetylation inferred from direct assay (Suganuma et al., 2008, Guelman et al., 2006) muscle organ development inferred from mutant phenotype (Parrish et al., 2006)
Cellular Component
CV term Evidence References
histone acetyltransferase complex inferred from direct assay (Guelman et al., 2006) nucleus inferred from direct assay (Weake et al., 2011) polytene chromosome inferred from direct assay (Kusch et al., 2003) SAGA complex inferred from direct assay (Weake et al., 2011)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
histone acetyltransferase activity inferred from sequence or structural similarity (Smith et al., 1997) inferred from sequence or structural similarity with Saccharomyces GCN5 (FlyBase, 1992-) non-traceable author statement (Smith, 1997.10.14)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR009464, InterPro:IPR016376 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
SAGA complex inferred from sequence or structural similarity with Saccharomyces GCN5 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pcaf allele Gene References unspecified dm (Secombe et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64780 DroID - A comprehensive database of gene and protein interactions. • FBgn0020388 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39431
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24008 Dere\GG13817 Dgri\GH16844 Dmoj\GI13063 Dper\GL24945 Dpse\GA17962 Dsec\GM24646 Dsim\GD12710 Dvir\GJ13812 Dwil\GK12618 Dyak\GE20112
Curated drosophilid orthologs	Dpse\GA17962
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000452-PA Aedes aegypti (mosquito) AGAP004434-PA Anopheles gambiae (mosquito) XP_001948706.1 Acyrthosiphon pisum (pea aphid) BGIBMGA009251-PA Bombyx mori (silk worm) ENSBTAP00000000994 Bos taurus (bovine) CN06854 Caenorhabditis brenneri (small nematode) CBP31998 Caenorhabditis briggsae (nematode) CE24372 Caenorhabditis elegans (worm) ENSCAFP00000023075 Canis familiaris (dog) ENSCINP00000003167 Ciona intestinalis (sea squirt) JA01248 Caenorhabditis japonica (nematode) CPIJ007462 Culex pipens (mosquito) ENSCPOP00000007469 Cavia porcellus (guinea pig) RP47624 Caenorhabditis remanei (nematode) ENSCSAVP00000011782 Ciona savignyi (sedentary tunicate) 158153 Capitella spl (polychaete worm) 307456 Daphnia pulex (daphnia) ENSDARP00000085195 Danio rerio (zebra fish) ENSECAP00000022648 Equus caballus (horse) ENSGACP00000006594 Gymnopilus aculeatus (mushroom) ENSGALP00000018380 Gallus gallus (chicken) 77335 Hypsipyla robusta (cedar shoot borer) ENSP00000225916 Homo sapiens (human) ISCW007018-PA Ixodes scapularis (deer tick) KLLA0A05115g Kluyveromyces lactis (yeast) 143660 Lottia gigantea (owl limpet) ENSMODP00000032522 Monodelphis domestica (gray opossum) ENSMMUP00000026770 Macaca mulatta (rhesus monkey) ENSMUSP00000000724 Mus musculus (house mouse) 96946 Nematostella vectensis (starlet anemone) XP_001602974.1 Nasonia vitripennis (wasp) ENSOANP00000007907 Ornithorynchus anatinus (platypus) ENSORLP00000015316 Oryzias latipes (japanese killifish) LOC_Os10g28040.1 Oryza sativa (asian rice) PHUM004609-PA Pediculus humanus (human body louse) PP21123 Pristionchus pacificus (nematode) ENSPPYP00000015742 Pongo pygmaeus (orangutan) ENSPTRP00000015659 Pan troglodytes (chimpanzee) PVX_089200 Plasmodium vivax (protozoal parasite) ENSRNOP00000052125 Rattus norvegicus (norway rat) 5048857 Sorghum bicolor (sorghum) Smp_070190 Schistosoma mansoni (trematode parasite) XP_784879.2 Strongylocentrotus purpuratus (purple sea urchin) 22087 Trichoplax adhaerens (metazoa) XP_969631.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014663 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046332 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004922 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12311 NV17151 LH14811 LH18448 ISCW007018 FBgn0237435 FBgn0214627 FBgn0201031 FBgn0184437 FBgn0179509 JGI_V11_307456 FBgn0077971 FBgn0162532 FBgn0144541 FBgn0135820 FBgn0124315 FBgn0106080 FBgn0101002 CPIJ007462 BGIBMGA009251 ACYPI006760 ACYPI004763 GB19492 AGAP004434 AAEL000452 PHUM067370 GLEAN_14774
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	9332 w1118; P{UAS-Pcaf.dsRNA}tc2-c 33981 y1 sc* v1; P{TRiP.HMS00941}attP2 35601 y1 sc* v1; P{TRiP.GL00439}attP40 18590 w1118; PBac{WH}Pcaff02830/TM6B, Tb1 18868 w1118; PBac{WH}Pcaff05456/TM6B, Tb1 29885 w1118; Mi{ET1}PcafMB09741/TM6C, Sb1 9335 w1118; PcafC137T P{FRT(whs)}2A e1/TM3, P{ActGFP}JMR2, Ser1 9333 w1118; PcafE333st P{FRT(whs)}2A e1/TM3, P{ActGFP}JMR2, Ser1
Harvard	- PBac{WH}Pcaff02830 - PBac{WH}Pcaff05456
VDRC	v21786 w1118; P{GD11218}v21786 v21787 w1118; P{GD11218}v21787
	More stocks available...
Genomic Clones ( 1 )
	BACR48G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 91 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11602
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH15365 GM01961 GM02234 GM10188 LD01003 LD03362 LD04652 LD05304 LD05327 LD05782 LD07034 LD10155 LD11548 LD17117 LD17309 LD17356 LD17946 LD18576 LD18611 LD19341 LD19593 LD20744 LD21994 LD26204 LD27065 LD27430 LD29012 LD31295 LD31608 LD31643 LD31889 LD34793 LD36152 LD36919 LD36935 LD38790 LD39540 LD39759 LD39784 LD40419 LD41454 LD44558 LD45539 LD46619 LP09312 RE01617 RE05917 RE08427 RE08443 RE36808 RE51534 RE53077 RE62782 RE65435 RE67404 RE71362 RE72394 RE73564 RH13622 RH14453 RH68493 SD02469 SD05306 SD21424
Other clones	20799 43921 55003 73061 81735 108296 CK01.51D.G2 CK01.141D.E12 CK01.143B.C6 CK01.168C.E6 EK103351 EK116343 EK118450 EK134715 EK160320 EK183020 EK215348 EK234327 ESG015b.E21_F07 ESG018a.E21_A08 ESG019b.E21.2_E10 ESG0111d.B21.1_B01 ESG0120d.B21_E02 RP003433857 RP003570605 RP003588270
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020388 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39431
Antibody Information
	polyclonal (Smith et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pcaf CG4107 (Bayraktaroglu, 1999.11)
Source for database merge of
Additional comments	Relationship of "Pcaf" to "HatB" unclear. (Smith, 1997.10.14)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Pcaf protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) dsRNA has been made from templates generated with primers directed against this gene. (Marr et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. RNAi of Pcaf causes an increase in lateral branching and a marked reduction in dorsal extension of ddaE neurons. RNAi also causes defects in muscle and defects in dendrite morphogenesis. (Parrish et al., 2006) Cloned by degenerate PCR using primers designed from human and yeast homologs. (Smith et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140329 RefSeq (Proteins) • NP_648586 DDBJ / EMBL / GenBank • AAC39102 AAF49904 AAL39242 AF029776 AI134208 AW940418 AX260127 AY069097 CZ485384 CZ488035 CZ488036 Entrez Gene - A searchable database of RefSeq genes. • 39431 UniProtKB/TrEMBL • O76216 Q9VTZ1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain, conserved site (IPR018359) GCN5-related N-acetyltransferase (GNAT) domain (IPR000182) Bromodomain (IPR001487) PCAF, N-terminal (IPR009464) Acyl-CoA N-acyltransferase (IPR016181) Histone acetylase PCAF (IPR016376)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64780 DroID - A comprehensive database of gene and protein interactions. • FBgn0020388 DRSC - Results from RNAi screens. • FBgn0020388 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020388 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4107-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020388 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 354269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39431 InParanoid A subset of ortholog calls from InParanoid. • AAEL000452-PA Aedes aegypti (mosquito) AGAP004434-PA Anopheles gambiae (mosquito) XP_001948706.1 Acyrthosiphon pisum (pea aphid) BGIBMGA009251-PA Bombyx mori (silk worm) ENSBTAP00000000994 Bos taurus (bovine) CN06854 Caenorhabditis brenneri (small nematode) CBP31998 Caenorhabditis briggsae (nematode) CE24372 Caenorhabditis elegans (worm) ENSCAFP00000023075 Canis familiaris (dog) ENSCINP00000003167 Ciona intestinalis (sea squirt) JA01248 Caenorhabditis japonica (nematode) CPIJ007462 Culex pipens (mosquito) ENSCPOP00000007469 Cavia porcellus (guinea pig) RP47624 Caenorhabditis remanei (nematode) ENSCSAVP00000011782 Ciona savignyi (sedentary tunicate) 158153 Capitella spl (polychaete worm) 307456 Daphnia pulex (daphnia) ENSDARP00000085195 Danio rerio (zebra fish) ENSECAP00000022648 Equus caballus (horse) ENSGACP00000006594 Gymnopilus aculeatus (mushroom) ENSGALP00000018380 Gallus gallus (chicken) 77335 Hypsipyla robusta (cedar shoot borer) ENSP00000225916 Homo sapiens (human) ISCW007018-PA Ixodes scapularis (deer tick) KLLA0A05115g Kluyveromyces lactis (yeast) 143660 Lottia gigantea (owl limpet) ENSMODP00000032522 Monodelphis domestica (gray opossum) ENSMMUP00000026770 Macaca mulatta (rhesus monkey) ENSMUSP00000000724 Mus musculus (house mouse) 96946 Nematostella vectensis (starlet anemone) XP_001602974.1 Nasonia vitripennis (wasp) ENSOANP00000007907 Ornithorynchus anatinus (platypus) ENSORLP00000015316 Oryzias latipes (japanese killifish) LOC_Os10g28040.1 Oryza sativa (asian rice) PHUM004609-PA Pediculus humanus (human body louse) PP21123 Pristionchus pacificus (nematode) ENSPPYP00000015742 Pongo pygmaeus (orangutan) ENSPTRP00000015659 Pan troglodytes (chimpanzee) PVX_089200 Plasmodium vivax (protozoal parasite) ENSRNOP00000052125 Rattus norvegicus (norway rat) 5048857 Sorghum bicolor (sorghum) Smp_070190 Schistosoma mansoni (trematode parasite) XP_784879.2 Strongylocentrotus purpuratus (purple sea urchin) 22087 Trichoplax adhaerens (metazoa) XP_969631.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014663 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046332 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004922 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/pcaf1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39431 modMine - Data generated by the modENCODE project. • FBgn0020388 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12311 NV17151 LH14811 LH18448 ISCW007018 FBgn0237435 FBgn0214627 FBgn0201031 FBgn0184437 FBgn0179509 JGI_V11_307456 FBgn0077971 FBgn0162532 FBgn0144541 FBgn0135820 FBgn0124315 FBgn0106080 FBgn0101002 CPIJ007462 BGIBMGA009251 ACYPI006760 ACYPI004763 GB19492 AGAP004434 AAEL000452 PHUM067370 GLEAN_14774
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	Ada4 (Guelman et al., 2006) anon-WO0172774.89   CG4107 (Ramet et al., 2002, Keleman et al., 2009.8.5, Weake et al., 2009, Gandhi et al., 2007, Ni et al., 2010.12.1, Ni et al., 2011.7.19) dGCN5 (Georgieva et al., 2001, Park et al., 2001, Smith et al., 1998, Kurshakova et al., 2007, Crump et al., 2011) dGcn5 (Swaminathan and Pile, 2010, Carre et al., 2005, Qi et al., 2004, Kusch et al., 2003, Muratoglu et al., 2003, Carre et al., 2005, Guelman et al., 2003, Kusch et al., 2003, Jacquier et al., 2007, Guelman et al., 2006, Weake et al., 2008, Ciurciu et al., 2006, Grau et al., 2008) dGCN5 HAT (Georgieva et al., 2000) dKAT2 (Weake et al., 2008, Crump et al., 2011) dmGCN5 (Lebedeva, 2005, Lebedeva et al., 2005) dmHAG401 (Pandey et al., 2002) dPCAF (Smith et al., 1997) GCN5 (Lebedeva, 2005, Lebedeva et al., 2005, Yang, 2004, Pankotai et al., 2005, Marr et al., 2006, Furrer et al., 2010, Tie et al., 2009, Boucher et al., 2001, Ferreira et al., 2007, Kopytova et al., 2010) Gcn5 (Dai and Mannervik, 2003, Smith, 1997.10.14, Di Croce et al., 1999, Carre et al., 2005, Guelman et al., 2006, Gause et al., 2006, Martinez and Arnosti, 2008, Weake et al., 2011, Hsu et al., 2008, Carré et al., 2008, Weake et al., 2009, Suganuma et al., 2008, Suganuma et al., 2010) gcn5 (Guelman et al., 2003, Weake et al., 2008) Gcn5/PCAF (Aoyagi and Wassarman, 2000) Gcn5/Pcaf (Guelman et al., 2006) KAT (Suganuma et al., 2010) P/CAF (Carre et al., 2004) p/CAF (Di Croce et al., 1999) Pcaf (Swaminathan and Pile, 2010, Parrish et al., 2006, Gan et al., 2010, Secombe et al., 2007, Ayroles et al., 2009, Tie et al., 2009) PCAF (Ma, 2005, Kuo and Allis, 1998, Filion et al., 2010)
Name Synonym	Pcaf
Secondary FlyBase IDs
	FBgn0046345
References ( 77 )
Generate a list of	All references relating to this gene ( 77 )
List References by type	Research paper  ( 42 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 ) Patent  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 9 )
	Crump et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 7814--7819 Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. [FBrf0213668] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Furrer et al., 2010, J. Biol. Chem. 285(51): 39623--39636 Drosophila Myc Interacts with Host Cell Factor (dHCF) to Activate Transcription and Control Growth. [FBrf0212501] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Kopytova et al., 2010, Genes Dev. 24(1): 86--96 Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. [FBrf0209575] Suganuma et al., 2010, Cell 142(5): 726--736 The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. [FBrf0214172] Swaminathan and Pile, 2010, Mech. Dev. 127(1-2): 96--106 Regulation of cell proliferation and wing development by Drosophila SIN3 and String. [FBrf0209854] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...