dGcn5, Pcaf, dmGCN5, dKAT2, KAT
a major histone H3 acetylase in Drosophila that plays a key role in the control of specific morphogenetic cascades during developmental transitions - Gcn5 interacts with Cyclin A to facilitate proper turnover in germ-line stem cells - Gcn5 promotes Cyclin A ubiquitination, which is dependent on its acetylating activity.
Please see the JBrowse view of Dmel\Gcn5 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
2.8 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
813 (aa); 998 (kD observed); 93 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gcn5 using the Feature Mapper tool.
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
GBrowse - Visual display of RNA-Seq signals
View Dmel\Gcn5 in GBrowse 23-38
3-32.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Pcaf CG4107
Source for identity of: Gcn5 Pcaf
FlyBase Curator comment: "Pcaf" renamed to "Gcn5" to reflect overwhelming usage in the literature and the symbol used in the first research paper to characterize the gene (FBrf0103041).
Relationship of "Pcaf" to "HatB" unclear.
DNA-protein interactions: genome-wide binding profile assayed for Pcaf protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Pcaf causes an increase in lateral branching and a marked reduction in dorsal extension of ddaE neurons. RNAi also causes defects in muscle and defects in dendrite morphogenesis.
Cloned by degenerate PCR using primers designed from human and yeast homologs.