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Gene Dmel\Nrk

General Information
Symbol	Dmel\Nrk	Species	D. melanogaster
Name	Neurospecific receptor kinase	Annotation symbol	CG4007
Feature type	protein_coding_gene	FlyBase ID	FBgn0020391
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Dnrk, DmHD-434, nrtk_dros
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49F4-49F4	Sequence location	2R:9,047,554..9,050,989 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Neurospecific receptor kinase is referred to in FlyBase by the symbol Dmel\Nrk (CG4007, FBgn0020391). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: protein phosphorylation; signal transduction. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Frizzled domain; Kringle; Kringle, conserved site; Kringle-like fold; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, receptor ROR, subgroup; Tyrosine-protein kinase, receptor Ror2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1635246_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nrk. Gene sequence location is 2R:9047554..9050989.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN20304 BKN50656 HFA07480 BKN51233
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49F4-49F4   Limits computationally determined from genome sequence between P{lacW}Psck07834&P{lacW}Su(z)2k06344 and P{EP}EP873EP873
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49F-49F   (determined by in situ hybridisation)   (Oishi et al., 1997) 49F7-49F8   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nrk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nrk-RA FBtr0087728  NM_057907   3249   724
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nrk-PA   FBpp0086841   81.8   724   6.62     NP_477255   AAF58420
Additional Polypeptide Data & Comments
Reported size (kDa)	714 (aa) (Oishi et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Kringle, conserved site (IPR018056) Kringle (IPR000001) Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Kringle-like fold (IPR013806) Tyrosine-protein kinase, receptor ROR, subgroup (IPR016247) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, receptor Ror2 (IPR020715) Frizzled domain (IPR020067) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58420   AB001420 BAA20134   AC005471   AF037164 AAD02091   AJ002920 CAA05755   AQ034035   BI243422   BI368028   BI375890   BI482018   BI579538   BT033065   CO272128   CO294520   CO305653   CO343372   CQ847774   EC053348   EC053799   EC054831   EC054851   EC055028   EC055342   EC055859   EC201374   EC203438   EC209198   EC230036   EC252410   EV580906
UniProtKB/Swiss-Prot	Q9V6K3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Oishi et al., 1997) embryonic stage 10 -- 17   neurogenic region   (Oishi et al., 1997) presumptive embryonic/larval central nervous system   (Oishi et al., 1997) embryonic stage 17   peripheral nervous system   (Oishi et al., 1997)
Additional Descriptive Data
	The 3.5 kb Nrk transcript is expressed at 4-22 hours of embryogenesis, with the highest embryonic expression at 4-10 hours. Expression continues to be detected in larvae, reaches its highest levels in pupae and is low in adult flies. Using in situ hybridization, embryonic expression is first detected at stage 10, in ventral regions of the germ band. Expression continues to be detected in the developing nervous system through the rest of embryonic development. (Oishi et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020391    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020391 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020391 expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr    2091 embryo 12-14hr    2045 embryo 14-16hr    2026 embryo 16-18hr    1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr  (109) embryo 04-06hr  (192) embryo 06-08hr  (686) embryo 08-10hr  (1178) embryo 10-12hr  (2091) embryo 12-14hr  (2045) embryo 14-16hr  (2026) embryo 16-18hr  (1623) embryo 18-20hr  (1197) embryo 20-22hr  (572) embryo 22-24hr  (703) larva L1  (575) larva L2  (239) larva L3 12hr old  (132) larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (412) larva L3 puffstage 7-9  (540) white prepupae new  (641) white prepupae 12hr  (1035) white prepupae 24hr  (1090) pupae 2d postWPP  (791) pupae 3d postWPP  (183) pupae 4d postWPP  (121) adult male 01day    98 adult male 05day  (128) adult male 30day  (136) adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr  (2091) embryo 12-14hr  (2045) embryo 14-16hr  (2026) embryo 16-18hr  (1623) embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr    2091 embryo 12-14hr    2045 embryo 14-16hr    2026 embryo 16-18hr    1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr    2091 embryo 12-14hr    2045 embryo 14-16hr    2026 embryo 16-18hr    1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020391 expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr    2091 embryo 12-14hr    2045 embryo 14-16hr    2026 embryo 16-18hr    1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr  109 embryo 04-06hr  (192) embryo 06-08hr  (686) embryo 08-10hr  (1178) embryo 10-12hr  (2091) embryo 12-14hr  (2045) embryo 14-16hr  (2026) embryo 16-18hr  (1623) embryo 18-20hr  (1197) embryo 20-22hr  (572) embryo 22-24hr  (703) larva L1  (575) larva L2  (239) larva L3 12hr old  132 larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (412) larva L3 puffstage 7-9  (540) white prepupae new  (641) white prepupae 12hr  (1035) white prepupae 24hr  (1090) pupae 2d postWPP  (791) pupae 3d postWPP  (183) pupae 4d postWPP  121 adult male 01day    98 adult male 05day  128 adult male 30day  136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr  2091 embryo 12-14hr  2045 embryo 14-16hr  2026 embryo 16-18hr  1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr    2091 embryo 12-14hr    2045 embryo 14-16hr    2026 embryo 16-18hr    1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    109 embryo 04-06hr    192 embryo 06-08hr    686 embryo 08-10hr    1178 embryo 10-12hr    2091 embryo 12-14hr    2045 embryo 14-16hr    2026 embryo 16-18hr    1623 embryo 18-20hr    1197 embryo 20-22hr    572 embryo 22-24hr    703 larva L1    575 larva L2    239 larva L3 12hr old    132 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    412 larva L3 puffstage 7-9    540 white prepupae new    641 white prepupae 12hr    1035 white prepupae 24hr    1090 pupae 2d postWPP    791 pupae 3d postWPP    183 pupae 4d postWPP    121 adult male 01day    98 adult male 05day    128 adult male 30day    136 adult female 01day    83 adult female 05day    61 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020391    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020391 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020391 expression level Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020391 expression level Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    97.275 Larval Midgut    2.4 Larval Hindgut    1.5 Larval Malpighian Tubules    4.5 Larval Fat Body    1.9 Larval Salivary Gland    3.9 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    7.6 Adult Eye    1.45 Adult Brain    17.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4 Adult Midgut    3.3 Adult Hindgut    6.7 Adult Malpighian Tubules    8.1 Adult Fat Body    3.6 Adult Salivary Gland    6.7 Adult Heart    6.45 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    1.9 Adult Ovary    2.6 Adult Testis    5 Adult Male Accessory Gland    1.2 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.6   NA  Eye    1.45   NA  Brain    17.7   97.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    4   2.4  Midgut    3.3   1.5  Hindgut    6.7   4.5  Malpighian Tubules    8.1   1.9  Fat Body    3.6   3.9  Salivary Gland    6.7   NA  Heart    6.45   1.025  Trachea    NA   NA  VirginFemale Spermatheca    1.9   NA  InseminatedFemale Spermatheca    1.9   NA  Ovary    2.6   NA  Testis    5   NA  Male Accessory Gland    1.2   1.45  Carcass    2.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4007-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Nrkk14301 viable, with Scer\GAL4pnr-MD237 NrkGD44 NrkGD2540 NrkGD14403 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Nrk Class Mutagen Stocks Known lesion Nrkk14301 P-element activity 2 Yes NrkG2759 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nrk Class Mutagen Stocks Known lesion NrkGD14403 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes NrkGD2540 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NrkGD44 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NrkKK100208 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8057 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD44} NA P{GD2540} NA P{GD14403} NA P{KK100208} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Nrkk14301 No insertion of mobile activating element P{EP}NrkG2759 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
protein tyrosine kinase activity inferred from direct assay (Oishi et al., 1997)
Biological Process
CV term Evidence References
protein phosphorylation inferred from direct assay (Oishi et al., 1997) signal transduction inferred from direct assay (Oishi et al., 1997)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR016247, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity non-traceable author statement (Minami, 1997.2.25, Oates, 1997.11.10, Morrison et al., 2000) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity (Oishi et al., 1997) inferred from sequence or structural similarity with EMBL:AF006464 (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000) transmembrane receptor protein tyrosine kinase signaling pathway inferred from electronic annotation with InterPro:IPR016247 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
plasma membrane inferred from sequence or structural similarity (Oishi et al., 1997)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nrk allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0020391 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36445
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12938 Dere\GG20358 Dgri\GH20314 Dmoj\GI19986 Dper\GL11237 Dpse\GA17849 Dsec\GM21445 Dsim\GD10943 Dvir\GJ21235 Dwil\GK21680 Dyak\GE12517
Curated drosophilid orthologs	Dpse\GA17849
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001370-PA Aedes aegypti (mosquito) AGAP006988-PA Anopheles gambiae (mosquito) XP_391863.3 Apis mellifera (honey bee) XP_001942959.1 Acyrthosiphon pisum (pea aphid) At1g21210.1 Arabidopsis thaliana (wall cress) BGIBMGA000354-PA Bombyx mori (silk worm) ENSBTAP00000003558 Bos taurus (bovine) ENSCAFP00000004412 Canis familiaris (dog) CPIJ002245 Culex pipens (mosquito) ENSCPOP00000011772 Cavia porcellus (guinea pig) 180235 Capitella spl (polychaete worm) ENSDARP00000028386 Danio rerio (zebra fish) ENSECAP00000008277 Equus caballus (horse) ENSGACP00000024106 Gymnopilus aculeatus (mushroom) ENSGALP00000025318 Gallus gallus (chicken) ENSP00000363571 Homo sapiens (human) 219301 Lottia gigantea (owl limpet) ENSMODP00000004898 Monodelphis domestica (gray opossum) ENSMMUP00000039675 Macaca mulatta (rhesus monkey) ENSMUSP00000095665 Mus musculus (house mouse) 84420 Nematostella vectensis (starlet anemone) XP_001601716.1 Nasonia vitripennis (wasp) ENSOANP00000011101 Ornithorynchus anatinus (platypus) ENSORLP00000015124 Oryzias latipes (japanese killifish) PHUM002649-PA Pediculus humanus (human body louse) ENSPPYP00000021837 Pongo pygmaeus (orangutan) 136671 Phytophthora sojae (root rot pathogen) 142741 Phytophthora sojae (root rot pathogen) ENSPTRP00000049076 Pan troglodytes (chimpanzee) ENSRNOP00000056324 Rattus norvegicus (norway rat) 4798026 Sorghum bicolor (sorghum) Smp_136550 Schistosoma mansoni (trematode parasite) ENSTNIP00000005174 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007874 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17724 NV11060 LH18048 ISCW007787 ISCW003016 FBgn0230255 FBgn0223665 FBgn0208368 FBgn0182706 FBgn0176326 JGI_V11_51694 FBgn0077858 FBgn0148846 FBgn0142723 FBgn0127778 FBgn0112549 FBgn0089972 CPIJ002245 BGIBMGA000354 ACYPI000994 GB15972 AGAP006988 AAEL001370 PHUM523320 GLEAN_14181
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	28454 y1 w*; P{EP}NrkG2759 CG34439G2759 11122 y1 w67c23; P{lacW}Nrkk14301 CG34439k14301 TppIIk14301/CyO
Kyoto	111339 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Nrkk14301 /CyO y+
VDRC	v103804 P{KK100208}VIE-260B v9653 w1118; P{GD2540}v9653 v841 w1118; P{GD44}v841/TM3 v36282 w1118; P{GD14403}v36282 v36284 w1118; P{GD14403}v36284 v42442 w1118; P{GD14403}v42442
Genomic Clones ( 1 )
	BACR48I10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE55360
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE41061 RE53930 RE63791 RE64658 RE73584
Other clones	7842 75117 146260 214371.39 CK01.63C.C10 Dmel_dig_006129_0666_3299 EC053348 EC053799 EC054831 EC054851 EC055028 EC055342 EC055859 EK105942 EK207125 EK249163 EP16655
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36445
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, spindle abnormalities, chromosome abnormalities are chromosome alignment defects are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification and characterisation of a new member of the Trk/Ror family RTKs, Nrk, which is expressed specifically in the developing nervous system during embryogenesis. (Oishi et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057907 RefSeq (Proteins) • NP_477255 DDBJ / EMBL / GenBank • AAD02091 AAF58420 AB001420 AC005471 AF037164 AJ002920 AQ034035 BAA20134 CAA05755 CQ847774 Entrez Gene - A searchable database of RefSeq genes. • 36445 UniProtKB/Swiss-Prot • Q9V6K3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Kringle, conserved site (IPR018056) Kringle (IPR000001) Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Kringle-like fold (IPR013806) Tyrosine-protein kinase, receptor ROR, subgroup (IPR016247) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, receptor Ror2 (IPR020715) Frizzled domain (IPR020067) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0020391 DRSC - Results from RNAi screens. • FBgn0020391 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4007-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36445 InParanoid A subset of ortholog calls from InParanoid. • AAEL001370-PA Aedes aegypti (mosquito) AGAP006988-PA Anopheles gambiae (mosquito) XP_391863.3 Apis mellifera (honey bee) XP_001942959.1 Acyrthosiphon pisum (pea aphid) At1g21210.1 Arabidopsis thaliana (wall cress) BGIBMGA000354-PA Bombyx mori (silk worm) ENSBTAP00000003558 Bos taurus (bovine) ENSCAFP00000004412 Canis familiaris (dog) CPIJ002245 Culex pipens (mosquito) ENSCPOP00000011772 Cavia porcellus (guinea pig) 180235 Capitella spl (polychaete worm) ENSDARP00000028386 Danio rerio (zebra fish) ENSECAP00000008277 Equus caballus (horse) ENSGACP00000024106 Gymnopilus aculeatus (mushroom) ENSGALP00000025318 Gallus gallus (chicken) ENSP00000363571 Homo sapiens (human) 219301 Lottia gigantea (owl limpet) ENSMODP00000004898 Monodelphis domestica (gray opossum) ENSMMUP00000039675 Macaca mulatta (rhesus monkey) ENSMUSP00000095665 Mus musculus (house mouse) 84420 Nematostella vectensis (starlet anemone) XP_001601716.1 Nasonia vitripennis (wasp) ENSOANP00000011101 Ornithorynchus anatinus (platypus) ENSORLP00000015124 Oryzias latipes (japanese killifish) PHUM002649-PA Pediculus humanus (human body louse) ENSPPYP00000021837 Pongo pygmaeus (orangutan) 136671 Phytophthora sojae (root rot pathogen) 142741 Phytophthora sojae (root rot pathogen) ENSPTRP00000049076 Pan troglodytes (chimpanzee) ENSRNOP00000056324 Rattus norvegicus (norway rat) 4798026 Sorghum bicolor (sorghum) Smp_136550 Schistosoma mansoni (trematode parasite) ENSTNIP00000005174 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007874 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36445 modMine - Data generated by the modENCODE project. • FBgn0020391 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17724 NV11060 LH18048 ISCW007787 ISCW003016 FBgn0230255 FBgn0223665 FBgn0208368 FBgn0182706 FBgn0176326 JGI_V11_51694 FBgn0077858 FBgn0148846 FBgn0142723 FBgn0127778 FBgn0112549 FBgn0089972 CPIJ002245 BGIBMGA000354 ACYPI000994 GB15972 AGAP006988 AAEL001370 PHUM523320 GLEAN_14181
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	anon-WO2004063362.79   CG4007 (Morrison et al., 2000, Whitfield, 2000.6.22, Kirienko and Fay, 2010, Keleman et al., 2009.8.5) DmHD-434 (Oates, 1997.11.10, Oates et al., 1998, ) Dnrk (Minami, 1997.2.25, Oishi et al., 1997, ) DNRK (Rehn et al., 1998) HD-434   l(2)k14301   Nrk (Sanchez, 2006, Kucherenko et al., 2008) nrk (Mattila et al., 2008) nrtk_dros (Saldanha et al., 1998, Saldanha et al., 1998) ROR2 (Banyai and Patthy, 2004)
Name Synonym	Drosophila neurospecific receptor kinase (Oishi et al., 1997) Neurospecific receptor kinase   neurospecific receptor tyrosine kinase (Minami, 1997.2.25)
Secondary FlyBase IDs
	FBgn0021861 FBgn0022790 FBgn0082206
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 5 ) Review  ( 3 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Kirienko and Fay, 2010, EMBO J. 29(4): 727--739 SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. [FBrf0210031] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...