FlyBase Gene Report: Dmel\JIL-1

General Information

Symbol

Dmel\JIL-1

Species

D. melanogaster

Name

JIL-1 kinase

Annotation Symbol

CG6297

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020412

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Snapshot

JIL-1 kinase (JIL-1) encodes a Serine/Threonine tandem kinase that phosphorylates the Serine 10 residue of the product of His3. A key function of the product of JIL-1 is to antagonize heterochromatization and to regulate levels of gene expression by controlling the distribution of the Lysine 9 dimethylation mark of the epigenetic histone encoded by His3. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Su(var)3-1, JIL1, MSK, Suppressor of variegation 3-1, Su-var(3)1

Key Links

Genomic Location

Cytogenetic map

68A5-68A6

Sequence location

3L:11,078,752..11,093,193 [-]

Recombination map

3-34

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

AGC KINASES (UNCLASSIFIED)

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q9V3I5)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

histone kinase activity (H3-S10 specific); protein binding; protein serine/threonine kinase activity

Predictions / Assertions

ATP binding; protein serine/threonine kinase activity

Summaries

Gene Group (FlyBase)

AGC KINASES (UNCLASSIFIED) -: The AGC kinase subfamily are serine/threonine kinases that were originally defined based on the sequence similarity of the catalytic domain. The AGC KINASE (UNCLASSIFIED) gene group represents AGC kinases that do not fall into the PKA, PKC or PKG families. (Adapted from FBrf0132098 and PMID:20027184).

Protein Function (UniProtKB)

Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A.

(UniProt, Q9V3I5)

Summary (Interactive Fly)

protein serine/threonine kinase involved in dosage compensation - phosphorylates the His3 Serine 10 residue - antagonizes heterochromatization - regulates levels of gene expression by controlling the distribution of the epigenetic histone His3 Lysine 9 dimethylation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\JIL-1 or the JBrowse view of Dmel\JIL-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

JIL-1-RA

FBtr0076237

NM_168439

5712

1207

JIL-1-RB

FBtr0076236

NM_140175

5147

1207

JIL-1-RC

FBtr0332707

NM_001274768

6550

1207

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

JIL-1-PA

FBpp0075966

137.0

1207

6.56

NP_729661

AAN11898

JIL-1-PB

FBpp0075965

137.0

1207

6.56

NP_648432

AAF50105

JIL-1-PC

FBpp0304953

137.0

1207

6.56

NP_001261697

AGB94391

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1207 aa isoforms: JIL-1-PA, JIL-1-PB, JIL-1-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with lola. Interacts with proteins of the male specific lethal (MSL) dosage compensation complex; this interaction is mediated by the kinase domains.

(UniProt, Q9V3I5)

Post Translational Modification

Autophosphorylated in vitro.

(UniProt, Q9V3I5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\JIL-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (22 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

histone kinase activity (H3-S10 specific)

inferred from mutant phenotype

(assigned by UniProt )

(Wang et al., 2001)

inferred from mutant phenotype

(Zhang et al., 2006)

protein binding

inferred from physical interaction with UniProtKB:Q7KQZ4

(assigned by UniProt )

(Zhang et al., 2003)

protein serine/threonine kinase activity

inferred from direct assay

(Jin et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR017892

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000682065

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

chromatin organization

inferred from mutant phenotype

(assigned by UniProt )

(Wang et al., 2001)

inferred from mutant phenotype

(Bao et al., 2007)

chromosome organization

inferred from mutant phenotype

(Zhang et al., 2003)

histone phosphorylation

inferred from direct assay

(assigned by UniProt )

(Jin et al., 1999)

inferred from mutant phenotype

(assigned by UniProt )

(Wang et al., 2001)

negative regulation of chromatin silencing

inferred from mutant phenotype

(Zhang et al., 2006)

oogenesis

inferred from mutant phenotype

(Zhang et al., 2003)

peptidyl-serine phosphorylation

inferred from mutant phenotype

(assigned by UniProt )

(Wang et al., 2001)

protein autophosphorylation

inferred from direct assay

(assigned by UniProt )

(Jin et al., 1999)

protein phosphorylation

inferred from direct assay

(Jin et al., 1999)

telomere maintenance

inferred from mutant phenotype

(Silva-Sousa and Casacuberta, 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000682065

(assigned by GO_Central )

(Gaudet et al., 2011)

protein phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000682065

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

colocalizes_with nuclear chromatin

inferred from direct assay

(Wang et al., 2001)

nuclear chromosome

inferred from direct assay

(assigned by UniProt )

(Jin et al., 1999)

inferred from direct assay

(Figueiredo et al., 2014)

nucleus

inferred from high throughput direct assay

(Lye et al., 2014)

polytene chromosome

inferred from direct assay

(Rath et al., 2006)

polytene chromosome interband

inferred from direct assay

(assigned by UniProt )

(Jin et al., 1999)

polytene chromosome puff

inferred from direct assay

(Ciurciu et al., 2009)

X chromosome located dosage compensation complex, transcription activating

inferred from physical interaction with UniProtKB:P50534

(assigned by UniProt )

(Jin et al., 2000)

inferred from physical interaction with UniProtKB:P50535

(assigned by UniProt )

(Jin et al., 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000682065

(assigned by GO_Central )

(Gaudet et al., 2011)

nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000682065

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with nuclear chromatin

inferred from direct assay

(Wang et al., 2001)

nuclear chromosome

inferred from direct assay

(assigned by UniProt )

(Jin et al., 1999)

inferred from direct assay

(Figueiredo et al., 2014)

nucleus

inferred from high throughput direct assay

(Lye et al., 2014)

polytene chromosome

inferred from direct assay

(Rath et al., 2006)

polytene chromosome interband

inferred from direct assay

(assigned by UniProt )

(Jin et al., 1999)

polytene chromosome puff

inferred from direct assay

(Ciurciu et al., 2009)

X chromosome located dosage compensation complex, transcription activating

inferred from physical interaction with UniProtKB:P50534

(assigned by UniProt )

(Jin et al., 2000)

inferred from physical interaction with UniProtKB:P50535

(assigned by UniProt )

(Jin et al., 2000)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}JIL-1^CPTI000274

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\JIL-1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\JIL-1

View exonic expression by tissue for Dmel\JIL-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020412

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6297-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6297

Flygut - An atlas of the Drosophila adult midgut

FBgn0020412

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 45 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 30 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of JIL-1

Transgenic constructs containing regulatory region of JIL-1

Deletions and Duplications ( 9 )

Disrupted in

Df(3L)h9

(Jin et al., 1997)

Df(3L)h76

(Jin et al., 1997)

Df(3L)lxd6

(Zhang et al., 2003)

Df(3L)lxd8

(Jin et al., 1997)

Df(3L)vin2

(Zhang et al., 2003)

Df(3L)vin5

(Zhang et al., 2003)

Not disrupted in

Df(3L)h76

(Zhang et al., 2003)

Df(3L)lxd8

(Zhang et al., 2003)

Df(3L)vin3

(Zhang et al., 2003)

Df(3L)vin4

(Zhang et al., 2003)

Partially disrupted in

Df(3L)h9

(Zhang et al., 2003)

Df(3L)JIL-1^z60

(Zhang et al., 2003)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^- :

JIL-1^EP3657

lethal (with JIL-1^z2)

JIL-1^z60

lethal (with JIL-1^z60)

JIL-1^z2

lethal | recessive

lethal - all die before end of embryonic stage | maternal effect (with JIL-1^EP3657), with Scer\GAL4^- :

JIL-1^z2

lethal - all die before end of embryonic stage | maternal effect (with JIL-1^h9)

JIL-1^z2

lethal - all die before end of embryonic stage | maternal effect (with JIL-1^z2)

JIL-1^h9

lethal - all die before end of embryonic stage | maternal effect (with JIL-1^z2), with Scer\GAL4^- :

JIL-1^EP3657

lethal - all die before end of embryonic stage | maternal effect | partially (with JIL-1^Scim)

JIL-1^z2

lethal - all die before end of embryonic stage | maternal effect | partially (with JIL-1^z2)

lethal - all die before end of embryonic stage | maternal effect | partially (with JIL-1^z28)

JIL-1^z2

partially lethal | recessive, with Scer\GAL4^- :

JIL-1^EP3657

partially lethal - majority die (with JIL-1^z2)

JIL-1^z60

partially lethal - majority die (with JIL-1^z60)

JIL-1^z2

viable

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

JIL-1^GL00146

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

female sterile (with JIL-1^h9)

JIL-1^z2

female sterile (with JIL-1^z2)

JIL-1^h9

fertile

fertile, with Scer\GAL4^- :

JIL-1^EP3657

Other Phenotypes

Allele

enhancer of variegation, with In(1)w^m4, Scer\GAL4^da.G32

enhancer of variegation, with JIL-1^CTD.UAS.ECFP, Scer\GAL4^da.G32

JIL-1^z2

enhancer of variegation, with JIL-1^z2, Scer\GAL4^da.G32

JIL-1^CTD.UAS.ECFP

enhancer of variegation, with P{hsp26-pt-T}39C-3

JIL-1^z60

enhancer of variegation, with P{hsp26-pt-T}118E-10

JIL-1^z60

enhancer of variegation, with P{hsp26-pt-T}118E-25

JIL-1^z60

enhancer of variegation, with P{hsp26-pt-T}118E-32

JIL-1^z60

enhancer of variegation (with JIL-1^CTD.UAS.ECFP), with Scer\GAL4^da.G32

JIL-1^z2

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}39C-3

JIL-1^z60

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-10

JIL-1^z60

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-25

JIL-1^z60

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-32

JIL-1^z60

enhancer of variegation (with JIL-1^z2), with Scer\GAL4^da.G32

JIL-1^CTD.UAS.ECFP

enhancer of variegation (with JIL-1^z60), with P{hsp26-pt-T}39C-3

JIL-1^z2

enhancer of variegation (with JIL-1^z60), with P{hsp26-pt-T}118E-10

JIL-1^z2

enhancer of variegation (with JIL-1^z60), with P{hsp26-pt-T}118E-25

JIL-1^z2

enhancer of variegation (with JIL-1^z60), with P{hsp26-pt-T}118E-32

JIL-1^z2

meiotic cell cycle defective | dominant

JIL-1^Scim

mitotic cell cycle defective | third instar larval stage

JIL-1^z2

modifier of variegation, with JIL-1^UAS.ECFP, Scer\GAL4^da.G32

JIL-1^z2

modifier of variegation, with JIL-1^z2, Scer\GAL4^da.G32

JIL-1^UAS.ECFP

modifier of variegation (with JIL-1^UAS.ECFP), with Scer\GAL4^da.G32

JIL-1^z2

modifier of variegation (with JIL-1^z2), with Scer\GAL4^da.G32

JIL-1^UAS.ECFP

non-suppressor of variegation | dominant, with P{RS5}5-HA-1902

JIL-1⁴

some die during embryonic stage | maternal effect (with JIL-1^EP3657), with Scer\GAL4^- :

JIL-1^z2

some die during embryonic stage | maternal effect (with JIL-1^h9)

JIL-1^z2

some die during embryonic stage | maternal effect (with JIL-1^z2)

JIL-1^h9

some die during embryonic stage | maternal effect (with JIL-1^z2), with Scer\GAL4^- :

JIL-1^EP3657

some die during embryonic stage | partially (with JIL-1^Scim)

JIL-1^z2

some die during embryonic stage | partially (with JIL-1^z2)

some die during embryonic stage | partially (with JIL-1^z28)

JIL-1^z2

suppressor of variegation, with Dp(1;f)γ238

JIL-1^unspecified

suppressor of variegation, with Dp(3;Y)BL2

JIL-1^unspecified

suppressor of variegation, with In(1)w^m4

suppressor of variegation, with In(3L)BL1

JIL-1^unspecified

suppressor of variegation, with JIL-1^z2, Scer\GAL4^da.G32

JIL-1^{ΔCTD.UAS.ECFP}

suppressor of variegation, with JIL-1^{ΔCTD.UAS.ECFP}, Scer\GAL4^da.G32

JIL-1^z2

suppressor of variegation, with P{hsp26-pt-T}39C-3

JIL-1³

suppressor of variegation, with P{hsp26-pt-T}118E-10

suppressor of variegation, with P{hsp26-pt-T}118E-25

JIL-1³

suppressor of variegation, with P{hsp26-pt-T}118E-32

JIL-1³

suppressor of variegation, with P{RS5}5-HA-1005

JIL-1⁴

suppressor of variegation, with T(1;4)w^m258-21

JIL-1^unspecified

suppressor of variegation, with T(2;3)Sb^V

JIL-1^unspecified

suppressor of variegation, with T(2;3)V21-P{lacW}92E.x3

JIL-1^unspecified

suppressor of variegation (with JIL-1^h9), with In(1)w^m4

JIL-1^z2

suppressor of variegation (with JIL-1^z2), with In(1)w^m4

suppressor of variegation (with JIL-1^z2), with Scer\GAL4^da.G32

JIL-1^{ΔCTD.UAS.ECFP}

suppressor of variegation (with JIL-1^z60), with In(1)w^m4

JIL-1^z2

suppressor of variegation (with JIL-1^{ΔCTD.UAS.ECFP}), with Scer\GAL4^da.G32

JIL-1^z2

suppressor of variegation | dominant, with In(1)w^m4

JIL-1⁴

suppressor of variegation | dominant, with In(1)w^m4h

suppressor of variegation | dominant, with P{RS3}pan^CB-5204-3

JIL-1⁴

suppressor of variegation | dominant, with P{RS5}5-HA-1992

JIL-1⁴

suppressor of variegation | dominant, with T(2;3)V21-P{lacW}92E.x3

JIL-1⁴

visible | adult stage, with Scer\GAL4^nub.PK

JIL-1^KK101300

visible | homeotic, with Scer\GAL4^- :

JIL-1^EP3657

visible | homeotic (with JIL-1^EP3657), with Scer\GAL4^- :

JIL-1^z2

visible | homeotic (with JIL-1^z2), with Scer\GAL4^- :

JIL-1^EP3657

wild-type

JIL-1^Hsp83.GFP

Phenotype manifest in

Allele

abdominal sternite 5 | ectopic | male, with Scer\GAL4^- :

JIL-1^EP3657

abdominal sternite 5 | ectopic | male (with JIL-1^EP3657), with Scer\GAL4^- :

JIL-1^z2

abdominal sternite 5 | ectopic | male (with JIL-1^z2), with Scer\GAL4^- :

JIL-1^EP3657

abdominal sternite 6 | male, with Scer\GAL4^- :

JIL-1^EP3657

abdominal sternite 6 | male (with JIL-1^EP3657), with Scer\GAL4^- :

JIL-1^z2

abdominal sternite 6 | male (with JIL-1^z2), with Scer\GAL4^- :

JIL-1^EP3657

chromatin, with Scer\GAL4^- :

JIL-1^EP3657

egg (with JIL-1^h9)

JIL-1^z2

egg (with JIL-1^z2)

JIL-1^h9

egg chamber (with JIL-1^h9)

JIL-1^z2

egg chamber (with JIL-1^z2)

JIL-1^h9

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

JIL-1^HMS04489

euchromatin

JIL-1^z2

intersegmental nerve, with Scer\GAL4^elav-C155

JIL-1^EP3657

larval neuroblast | third instar larval stage

JIL-1^z2

nucleus, with Scer\GAL4^- :

JIL-1^EP3657

nurse cell (with JIL-1^h9)

JIL-1^z2

nurse cell (with JIL-1^z2)

JIL-1^h9

oocyte nucleus (with JIL-1^h9)

JIL-1^z2

oocyte nucleus (with JIL-1^z2)

JIL-1^h9

ovariole (with JIL-1^h9)

JIL-1^z2

ovariole (with JIL-1^z2)

JIL-1^h9

ovary, with Scer\GAL4^- :

JIL-1^EP3657

ovary (with JIL-1^h9)

JIL-1^z2

ovary (with JIL-1^z2)

JIL-1^h9

polytene chromosome

polytene chromosome, with Scer\GAL4^- :

JIL-1^EP3657

polytene chromosome (with JIL-1^h9)

JIL-1^z2

polytene chromosome (with JIL-1^z2)

JIL-1^h9

polytene chromosome | larval stage

JIL-1^z2

polytene chromosome | larval stage, with Scer\GAL4^hs.PB

JIL-1^{ΔCTD.UAS.GFP}

polytene chromosome | male

polytene chromosome band | male

JIL-1^z2

polytene chromosome band | male (with JIL-1^h9)

JIL-1^z2

polytene chromosome band | male (with JIL-1^z2)

JIL-1^h9

polytene chromosome interband

JIL-1^z2

polytene chromosome interband (with JIL-1^h9)

JIL-1^z2

polytene chromosome interband (with JIL-1^z2)

JIL-1^h9

spindle, with Scer\GAL4^- :

JIL-1^EP3657

spindle | third instar larval stage

JIL-1^z2

wing anterior compartment, with Scer\GAL4^nub.PK

JIL-1^KK101300

wing vein, with Scer\GAL4^nub.PK

JIL-1^KK101300

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RPS6KA5

10 of 15

Yes

Hsap\RPS6KA4

9 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rps6ka5

8 of 15

Yes

Mmus\Rps6ka4

7 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Rps6ka4

7 of 13

Yes

Rnor\Rps6ka5

4 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Stk32a

1 of 13

Rnor\Stk32b

1 of 13

Rnor\Stk32c

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\rps6ka4

4 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (19)

Drer\rps6ka4

9 of 15

Yes

Drer\rps6ka5

9 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-195b13.1

1 of 15

Drer\stk32a

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\rskn-2

7 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\PK1

3 of 9

Yes

Atha\S6K2

3 of 9

Yes

Atha\AT3G19100

1 of 9

Atha\CIPK17

1 of 9

Atha\NEK2

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\YPK3

3 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\psk1

2 of 12

Yes

Spom\ppk1

1 of 12

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919029O )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\JIL-1

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA23554

Drosophila pseudoobscura pseudoobscura

Dpse\GA22763

Drosophila persimilis

Dper\GL24920

Drosophila persimilis

Dper\GL25406

Drosophila willistoni

Dwil\GK13379

Drosophila virilis

Dvir\GJ11970

Drosophila mojavensis

Dmoj\GI13195

Drosophila grimshawi

Dgri\GH16260

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500S3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17006903

Glossina morsitans

Tsetse fly

Gmor\GMOY002331

Glossina morsitans

Tsetse fly

Gmor\GMOY002332

Glossina morsitans

Tsetse fly

Gmor\GMOY001854

Mayetiola destructor

Hessian fly

Mdes\Mdes001670

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011145

Anopheles darlingi

American malaria mosquito

Adar\ADAC000072

Anopheles gambiae

Malaria mosquito

Agam\CPR106

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011936

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012176

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0217 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA011088

Bombyx mori

Silkmoth

Bmor\BGIBMGA000142

Danaus plexippus

Monarch butterfly

Dple\DPOGS203202-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS205511-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005786

Heliconius melpomene

Postman butterfly

Hmel\HMEL011296

Heliconius melpomene

Postman butterfly

Hmel\HMEL015753

Apis florea

Little honeybee

Aflo\2452734196

Apis florea

Little honeybee

Aflo\4102039604

Apis mellifera

Western honey bee

Amel\S6kII

Apis mellifera

Western honey bee

Amel\GB40565

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18811

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11539

Bombus terrestris

Buff-tailed bumblebee

Bter\15207129

Bombus terrestris

Buff-tailed bumblebee

Bter\15216629

Linepithema humile

Argentine ant

Lhum\LH21897

Linepithema humile

Argentine ant

Lhum\LH19909

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00270f

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002f1a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013142

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004335

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01859

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03427

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09351

Tribolium castaneum

Red flour beetle

Tcas\TC001074

Tribolium castaneum

Red flour beetle

Tcas\TC000021

Pediculus humanus

Human body louse

Phum\PHUM508900

Pediculus humanus

Human body louse

Phum\PHUM599900

Rhodnius prolixus

Kissing bug

Rpro\RPRC003727

Rhodnius prolixus

Kissing bug

Rpro\RPRC000863

Cimex lectularius

Bed bug

Clec\CLEC007762

Cimex lectularius

Bed bug

Clec\CLEC007763

Cimex lectularius

Bed bug

Clec\CLEC006450

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI47192

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004772

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17521

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00262

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03WL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011282

Strigamia maritima

European centipede

Smar\SMAR015072

Strigamia maritima

European centipede

Smar\SMAR001186

Strigamia maritima

European centipede

Smar\SMAR015647

Ixodes scapularis

Black-legged tick

Isca\ISCW017390

Ixodes scapularis

Black-legged tick

Isca\ISCW012610

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82508.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68004.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65578.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM64654.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66159.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g08980

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g01350

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g14060

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_225339

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_23503

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_318992

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01KO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Msk_1

Ciona intestinalis

Vase tunicate

Cint\rps6ka5

Gallus gallus

Domestic chicken

Ggal\RPS6KA5

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

S6k

3 of 10

2 of 10

2 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

JIL-1^KG08229

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Park et al., 2013)

JIL-1^KK101300

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Park et al., 2013)

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPS6KA5; ribosomal protein S6 kinase A5

10 of 15

603607

RPS6KA4; ribosomal protein S6 kinase A4

9 of 15

603606

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

JIL-1 - Chro

far western blotting, western blot, anti bait coimmunoprecipitation, coimmunoprecipitation

(Gan et al., 2011, Rath et al., 2006)

JIL-1 - His2Av

pull down, western blot, enzymatic study, autoradiography

(Thomas et al., 2014)

JIL-1 - His3

enzymatic study, western blot, autoradiography, pull down, far western blotting, anti tag western blot

(Thomas et al., 2014, Bao et al., 2008)

JIL-1 - Lam

anti bait coimmunoprecipitation, western blot, pull down, two hybrid

(Bao et al., 2005)

JIL-1 - Parp

pull down, western blot

(Thomas et al., 2014)

JIL-1 - Su(var)3-9

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, autoradiography, pull down, affinity chromatography technology, western blot

(Boeke et al., 2010)

JIL-1 - lola

two hybrid, anti bait coimmunoprecipitation, western blot, pull down

(Zhang et al., 2003)

JIL-1 - msl-1

proximity ligation assay, fluorescence microscopy, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, pull down

(Lindehell et al., 2015, Jin et al., 2000)

JIL-1 - msl-2

western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, anti tag western blot, proximity ligation assay, fluorescence microscopy

(Lindehell et al., 2015, Jin et al., 2000)

JIL-1 - msl-3

anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Zee et al., 2016, Alekseyenko et al., 2014, Jin et al., 2000)

JIL-1 - pzg

anti bait coimmunoprecipitation, western blot

(Silva-Sousa et al., 2012, Gan et al., 2011)

RNA-RNA

Physical Interaction

Assay

References

JIL-1 - mir-124

luminiscence technology

(Sun et al., 2012)

RNA-protein

Physical Interaction

Assay

References

JIL-1 - Unr

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Mihailovich et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

JIL-1

suppressible

lola

(Zhang et al., 2003)

JIL-1

suppressible

Su(var)3-9

(Deng et al., 2007, Zhang et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm|trx

enhanceable

JIL-1

(Zhang et al., 2003)

Chro

enhanceable

JIL-1

(Rath et al., 2006)

E(var)2-1

suppressible

JIL-1

(Lerach et al., 2006)

External Data

Subunit Structure (UniProtKB)

Interacts with lola. Interacts with proteins of the male specific lethal (MSL) dosage compensation complex; this interaction is mediated by the kinase domains.

(UniProt, Q9V3I5 )

Linkouts

BioGRID - A database of protein and genetic interactions.

64615

DroID - A comprehensive database of gene and protein interactions.

FBgn0020412

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39241

MIST (genetic) - An integrated Molecular Interaction Database

JIL-1

MIST (protein-protein) - An integrated Molecular Interaction Database

JIL-1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-34

Cytogenetic map

68A5-68A6

Sequence location

3L:11,078,752..11,093,193 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

68A5-68A6

Limits computationally determined from genome sequence between P{PZ}l(3)01239⁰¹²³⁹&P{lacW}l(3)01239^j9B4 and P{PZ}CycA⁰²⁴⁶¹&P{PZ}CycA⁰³⁹⁴⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

68A-68A

(determined by in situ hybridisation)

(Zhang et al., 2003)

68A4-68A5

(Jin, 1999.4.11, Jin et al., 1997)

Localised by deficiency mapping, chromosomes unspecified.

(Jin et al., 1997)

Experimentally Determined Recombination Data

Location

3-34

(FlyBase, 2016)

3-28.4

(Comeron et al., 2012)

(Jin et al., 1997)

3-31.4 +/- 0.8

(Reuter et al., 1986)

3-31.4

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Bloomington

42571

y¹ v¹; P{TRiP.HMJ02230}attP40

63894

w¹¹¹⁸; PBac{IT.GAL4}JIL-1^0916-G4

14572

y¹; P{SUPor-P}JIL-1^Scim ry⁵⁰⁶

20854

y¹ w^67c23; P{EPgy2}JIL-1^EY13085

21352

y¹ w^67c23; P{EPgy2}JIL-1^EY04795

6347

In(1)w^m4h; JIL-1³/TM3, Sb¹ Ser¹

55875

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04148}attP2

Kyoto

115019

w¹¹¹⁸; PBac{602.P.SVS-1}JIL-1^CPTI000274

115516

w¹¹¹⁸; PBac{681.P.FSVS-1}JIL-1^CPTI001616

VDRC

v330134

P{VSH330134}attP40

v107001

P{KK101300}VIE-260B

v342443

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01360}attP40/CyO-GFP

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (82)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020412

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020412

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39241

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zielke et al., 2016, Riddle et al., 2012, Regnard et al., 2011, Jin et al., 2000)

monoclonal

(Jin et al., 2000)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

5C9-2C7

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: JIL-1 CG6297

(Zhang, 1999.11)

Source for database merge of

Source for merge of: JIL-1 Su(var)3-1

(Ebert et al., 2004)

Source for merge of: JIL-1 anon-WO0118547.379

(FlyBase, 1996-)

Additional comments

Source for merge of JIL-1 anon-WO0118547.379 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Loss of function mutations in JIL-1 are strong suppressors of position effect variegation.

(Lerach et al., 2006)

The COOH-terminal domain of the JIL-1 product is required for correct chromosome localization.

(Zhang et al., 2006)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells is seen.

(Bettencourt-Dias et al., 2004)

JIL-1 has a role in controlling heterochromatin compaction and expansion.

(Ebert et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila EST AA246367. This EST has sequence similarity to human ribosome S6 PK gene.

(Davies, 2001.3.15)

In JIL-1 hypomorphs, euchromatic regions of polytene chromosomes are severely reduced and the chromosome arms are condensed. This is correlated with decreased levels of His3 protein Ser10 phosphorylation.

(Wang et al., 2001)

JIL-1 may play a role in transcriptional control, potentially by regulating chromatin structure.

(Jin et al., 1999)

Isolated in an expression library screen using monoclonal antibody 2A (mAb2A).

(Jin et al., 1997)

Mutations exhibit a small discs phenotype.

(Jin et al., 1997)

Monoclonal antibody mAb2A, which recognises Skeletor and JIL-1 proteins, disrupts nuclear morphology and perturbs mitosis when injected into early syncytial embryos.

(Johansen et al., 1996)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 87 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39241

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3I5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PI05

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020412

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6297

Flygut - An atlas of the Drosophila adult midgut

FBgn0020412

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39241

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6297

modMine - A data warehouse for the modENCODE project

FBgn0020412

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V3I5

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

13330-JIL1[KG02848]

BioGRID - A database of protein and genetic interactions.

64615

DroID - A comprehensive database of gene and protein interactions.

FBgn0020412

DRSC - Results frm RNAi screens

FBgn0020412

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

5C9-2C7

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020412

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6297-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020412

FlyMine - An integrated database for Drosophila genomics

FBgn0020412

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39241

MIST (genetic) - An integrated Molecular Interaction Database

JIL-1

MIST (protein-protein) - An integrated Molecular Interaction Database

JIL-1

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

2Ab17

(Walker et al., 1995)

CG6297

(Meadows, 2017.1.11, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Haussmann et al., 2008, Makunin et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000)

IL-1

(Deng et al., 2005)

JIL

(Wutz, 2003)

JIL-1

(Luzhin et al., 2019, El-Sharnouby et al., 2017, Li et al., 2017, Clandinin and Owens, 2016-, Ulianov et al., 2016, Zee et al., 2016, Di Cara et al., 2015, Dietz et al., 2015, Kanoh et al., 2015, Kwong et al., 2015, Lucchesi and Kuroda, 2015, Alekseyenko et al., 2014, Ashwal-Fluss et al., 2014, Comoglio and Paro, 2014, Ho et al., 2014, Liu et al., 2014, Lye et al., 2014, Sopko et al., 2014, Thomas et al., 2014, Wang et al., 2014, Zhimulev et al., 2014, Girton et al., 2013, Li et al., 2013, Park et al., 2013, Raffa et al., 2013, Silva-Sousa and Casacuberta, 2013, Wang et al., 2013, Wang et al., 2013, Alekseyenko et al., 2012, Hainaut et al., 2012, Hohl et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kellner et al., 2012, Riddle et al., 2012, Sakoparnig et al., 2012, Sun et al., 2012, Takács et al., 2012, Yao et al., 2012, Demakov et al., 2011, Gan et al., 2011, Regnard et al., 2011, Wang et al., 2011, Wang et al., 2011, Boeke et al., 2010, Deng et al., 2010, Huang et al., 2010, Karam et al., 2010, Ciurciu et al., 2009, Ding et al., 2009, Bao et al., 2008, Cai et al., 2008, Ciurciu et al., 2008, Deng et al., 2008, Bao et al., 2007, Deng et al., 2007, Ivaldi et al., 2007, Deng and Meller, 2006, Johansen and Johansen, 2006, Lerach et al., 2006, Liebl et al., 2006, Mendjan et al., 2006, Andreyeva et al., 2005, Bao et al., 2005, Beckstead et al., 2005, Lam et al., 2005, Lerach et al., 2005, Zhimulev et al., 2003, Jin et al., 2000)

JIL1

(Rennie et al., 2018, Lindehell et al., 2015, Figueiredo et al., 2014, Ost et al., 2014, Li and Zhou, 2013, Grewal and Elgin, 2007, Straub and Becker, 2007, Gilfillan et al., 2004, Birchler et al., 2001)

Jil-1

(Li et al., 2017, Koya and Meller, 2015, McElroy et al., 2014, Zielke and Saumweber, 2014, Mihailovich et al., 2012, Prabhakaran and Kelley, 2012, Jin, 1999.4.11)

Jil1

(Zielke et al., 2016, Eggert et al., 2005)

MSK

(Bjorklund et al., 2006, Morrison et al., 2000)

MSK1

(Park et al., 2013)

Su(var)3-1

(Ost et al., 2014, Elgin and Reuter, 2013, Abramov et al., 2011, Phalke et al., 2009, Reuter et al., 2005, Joanis and Lloyd, 2002, Westphal and Reuter, 2002, Kurenova et al., 1998)

Su(var)3-103

(Netter et al., 1998)

Su-var(3)1

(Wustmann et al., 1989, Reuter et al., 1986)

Su-var(3)103

(Fauvarque and Dura, 1993)

anon-WO0118547.379

mAb2A

(Johansen et al., 1996)

Name Synonyms

JIL-1

JIL-1 histone H3S10 kinase