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Gene Dmel\Idgf3

General Information
Symbol	Dmel\Idgf3	Species	D. melanogaster
Name	Imaginal disc growth factor 3	Annotation symbol	CG4559
Feature type	protein_coding_gene	FlyBase ID	FBgn0020414
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	BG:DS02780.2, IDGF
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	36A1-36A1	Sequence location	2L:16,450,907..16,455,194 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Imaginal disc growth factor 3 is referred to in FlyBase by the symbol Dmel\Idgf3 (CG4559, FBgn0020414). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: imaginal disc growth factor receptor binding. There is experimental evidence that it is involved in the biological process: imaginal disc development. 24 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Chitinase II; Glycoside hydrolase, catalytic domain; Glycoside hydrolase, family 18, catalytic domain; Glycoside hydrolase, superfamily; Imaginal disc growth factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut. Gene sequence location is 2L:16450907..16454538.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides Idgf3-PD Transcripts Idgf3-RD
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36A1-36A1   Limits computationally determined from genome sequence between P{EP}fzyEP1028&P{lacW}mRpL4k14608 and P{PZ}dacP
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36A2-36A4     (Kawamura, 1998.10.28) 36A2-36A4     (Kawamura et al., 1997)
Experimentally Determined Recombination Data
Location	2- (Kawamura et al., 1997)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Idgf3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Idgf3-RA FBtr0080864  NM_057908   1649   441 Idgf3-RB FBtr0080863  NM_165157   3145   441 Idgf3-RC FBtr0080862  NM_165158   1724   441 Idgf3-RD FBtr0342945     3801   441
Additional Transcript Data & Comments
Reported size (kB)	1.683 (longest cDNA) (Kawamura et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Idgf3-PA   FBpp0080421   49.3   441   7.62     NP_477256   AAF53537 Idgf3-PB   FBpp0080420   49.3   441   7.62     NP_723966   AAN10940 Idgf3-PC   FBpp0080419   49.3   441   7.62     NP_723967   AAN10941 Idgf3-PD   FBpp0309719   49.3   441   7.62
Additional Polypeptide Data & Comments
Reported size (kDa)	441 (aa) (Kawamura et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 18, catalytic domain (IPR001223) Chitinase II (IPR011583) Imaginal disc growth factor (IPR015520) Glycoside hydrolase, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140680   AA140749   AA695975   AA696436   AA697525   AA802437   AE014134 AAF53537   AE014134 AAN10940   AE014134 AAN10941   AC093177   AE003416 AAF45018   AF102238 AAC99419   AF394713 AAM69645   AF394714 AAM69646   AF394715 AAM69647   AF394716 AAM69648   AF394717 AAM69649   AF394718 AAM69650   AF394719 AAM69651   AF394720 AAM69652   AF394721 AAM69653   AF394722 AAM69654   AF394723 AAM69655   AF394724 AAM69656   AF394725 AAM69657   AF394726 AAM69658   AF394727 AAM69659   AF394728 AAM69660   AF394729 AAM69661   AF394730 AAM69662   AF394731 AAM69663   AF394732 AAM69664   AI108968   AI109961   AI296507   AI387637   AI389527   AI402082   AI945837   AY047561 AAK77293   BF493906   BF499298   BF500209   BF501915   BF503918   BG635529   BI215098   BI232243   BI232652   BI361734   BI362835   BI362846   BI374907   BI374923   BI633636   BI640572   CA803665   CA804637   CA804964   CA805754   CA806573   CA807009   CA807249   CA807394   CA807597   CA807790   CO154755   CO184198   CO190877   CO195843   CO265648   CO268116   CO281697   CO282974   CO296260   CO320231   CO332446   CO335497   EC056979   EC205099   EC207032   EC224861   EC239151   EC263796   EC264980   GH755430   GH781398   GH781866   GH783827   GH791395   GH794427   GH795698   GH796849   GH806822   GH807656   GH810222   GH818447   GH825401   GH829184   GH834120   GH837679   GH838491   GH839043   GH840477   GH843887   GH848179   GH849171   GH859431   GH861374   GH867487   GH869900   GH870727   GH874503   GH875229   GH879494   GH885112   GH886145   GH888149   GH889737   GH890012   GH890199   GH898197   GH902157   GH902704   GH904283   GH919481   GH922212   GH929904   GH932780   GH936434   GH939683
UniProtKB/Swiss-Prot	Q8MLZ7
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral furrow | vicinity of   (Kawamura et al., 1999) amnioproctodeal invagination | vicinity of   (Kawamura et al., 1999) embryonic stage & larval stage   embryonic/larval salivary gland   (Kawamura et al., 1999) third instar larval stage   embryonic/larval brain   (Kawamura et al., 1999) ring gland   (Kawamura et al., 1999) imaginal disc   (Kawamura et al., 1999) adult stage & oogenesis   oocyte   (Kawamura et al., 1999) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   cephalic furrow | vicinity of   (Kawamura et al., 1999) embryonic/larval tracheal system   (Kawamura et al., 1999) yolk   (Kawamura et al., 1999) embryonic stage & larval stage   embryonic/larval fat body   (Kawamura et al., 1999) embryonic stage 11 -- 12   yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval fat body   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) third instar larval stage   embryonic/larval optic lobe   (Kawamura et al., 1999) embryonic/larval lymph gland   (Kawamura et al., 1999) adult stage & oogenesis   nurse cell   (Kawamura et al., 1999)
Additional Descriptive Data
	Idgf3 transcripts are expressed at all stages tested on northern blots but most heavily in mid-larval stages. Idgf3 transcripts are present in the yolk cytoplasm in the early embryo but are excluded from the blastoderm as it cellularizes. During gastrulation, transcripts are observed in rows parallel to the major invaginations including the ventral furrow, the cephalic furrow, and the anterior and posterior midgut invaginations. In late embryos, Idgf3 transcripts are observed in yolk cells, fat body, salivary glands, and in the tracheal system. In third instar larvae, Idgf3 transcripts are strongly expressed in fat body, the ring gland, and in lymph glands. Expression is also observed in the optic lobes, the central brain, and in imaginal discs. Duing oogenesis, Idgf3 transcripts are present in nurse cells and in the oocyte. While the patterns of expression of the four Idgf genes are in general very similar, they are differentially expressed in the larval salivary glands. Levels of Idgf2 and Idgf4 are generally higher than Idgf1 and Idgf3. (Kawamura et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female    43 head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female    31 head, mated 1-day male    25 head, mated 4-day male    32 head, mated 20-day male    46 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    37 digestive system, 4-day adult    27 digestive system, 20-day adult    29 fat body, larvae L3 wandering    60 fat body, white prepupae    45 fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult    37 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    83 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female  (43) head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female  (31) head, mated 1-day male    25 head, mated 4-day male  (32) head, mated 20-day male  (46) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult  (37) digestive system, 4-day adult  (27) digestive system, 20-day adult  (29) fat body, larvae L3 wandering  (60) fat body, white prepupae  (45) fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult  (37) ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male  (83) accessory gland, mated 4-day male  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female    43 head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female    31 head, mated 1-day male    25 head, mated 4-day male    32 head, mated 20-day male    46 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    37 digestive system, 4-day adult    27 digestive system, 20-day adult    29 fat body, larvae L3 wandering    60 fat body, white prepupae    45 fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult    37 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    83 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female    43 head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female    31 head, mated 1-day male    25 head, mated 4-day male    32 head, mated 20-day male    46 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    37 digestive system, 4-day adult    27 digestive system, 20-day adult    29 fat body, larvae L3 wandering    60 fat body, white prepupae    45 fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult    37 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    83 accessory gland, mated 4-day male    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female    43 head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female    31 head, mated 1-day male    25 head, mated 4-day male    32 head, mated 20-day male    46 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    37 digestive system, 4-day adult    27 digestive system, 20-day adult    29 fat body, larvae L3 wandering    60 fat body, white prepupae    45 fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult    37 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    83 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female  (43) head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female  31 head, mated 1-day male    25 head, mated 4-day male  32 head, mated 20-day male  (46) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult  (37) digestive system, 4-day adult  27 digestive system, 20-day adult  29 fat body, larvae L3 wandering  (60) fat body, white prepupae  (45) fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult  (37) ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male  (83) accessory gland, mated 4-day male  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female    43 head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female    31 head, mated 1-day male    25 head, mated 4-day male    32 head, mated 20-day male    46 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    37 digestive system, 4-day adult    27 digestive system, 20-day adult    29 fat body, larvae L3 wandering    60 fat body, white prepupae    45 fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult    37 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    83 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    23 head, virgin 20-day female    43 head, mated 1-day female    18 head, mated 4-day female    23 head, mated 20-day female    31 head, mated 1-day male    25 head, mated 4-day male    32 head, mated 20-day male    46 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    37 digestive system, 4-day adult    27 digestive system, 20-day adult    29 fat body, larvae L3 wandering    60 fat body, white prepupae    45 fat body, pupae P8    21 carcass, larvae L3 wandering    23 carcass, 1-day adult    23 carcass, 4-day adult    22 carcass, 20-day adult    37 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    83 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    29 larva L3 12hr old    41 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day    33 adult male 05day    36 adult male 30day    33 adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr  (28) larva L1    22 larva L2  (29) larva L3 12hr old  (41) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  (29) white prepupae new    25 white prepupae 12hr  (27) white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day  (33) adult male 05day  (36) adult male 30day  (33) adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    29 larva L3 12hr old    41 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day    33 adult male 05day    36 adult male 30day    33 adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    29 larva L3 12hr old    41 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day    33 adult male 05day    36 adult male 30day    33 adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    29 larva L3 12hr old    41 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day    33 adult male 05day    36 adult male 30day    33 adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr  28 larva L1    22 larva L2  29 larva L3 12hr old  (41) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  29 white prepupae new    25 white prepupae 12hr  27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day  (33) adult male 05day  (36) adult male 30day  (33) adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    29 larva L3 12hr old    41 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day    33 adult male 05day    36 adult male 30day    33 adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    7 embryo 10-12hr    14 embryo 12-14hr    11 embryo 14-16hr    10 embryo 16-18hr    16 embryo 18-20hr    23 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    29 larva L3 12hr old    41 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    27 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    23 adult male 01day    33 adult male 05day    36 adult male 30day    33 adult female 01day    13 adult female 05day    10 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    77 Schneider line 2 Sg4    37 embryonic 1182-4H    108 embryonic GM2    93 embryonic Kc167    52 embryonic S1    309 embryonic S3    78 leg disc CME L1    26 wing disc CME-W2    52 wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    108 wing disc ML-DmD21    16 wing disc ML-DmD32    97 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    132 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    119 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (77) Schneider line 2 Sg4  (37) embryonic 1182-4H  (108) embryonic GM2  (93) embryonic Kc167  (52) embryonic S1  (309) embryonic S3  (78) leg disc CME L1  26 wing disc CME-W2  (52) wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  (108) wing disc ML-DmD21    16 wing disc ML-DmD32  (97) haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (132) antennal disc ML-DmD20-c5  (134) mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2  (119) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    77 Schneider line 2 Sg4    37 embryonic 1182-4H  (108) embryonic GM2    93 embryonic Kc167    52 embryonic S1  (309) embryonic S3    78 leg disc CME L1    26 wing disc CME-W2    52 wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  (108) wing disc ML-DmD21    16 wing disc ML-DmD32    97 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (132) antennal disc ML-DmD20-c5  (134) mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2  (119) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    77 Schneider line 2 Sg4    37 embryonic 1182-4H    108 embryonic GM2    93 embryonic Kc167    52 embryonic S1    309 embryonic S3    78 leg disc CME L1    26 wing disc CME-W2    52 wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    108 wing disc ML-DmD21    16 wing disc ML-DmD32    97 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    132 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    119 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    77 Schneider line 2 Sg4    37 embryonic 1182-4H    108 embryonic GM2    93 embryonic Kc167    52 embryonic S1    309 embryonic S3    78 leg disc CME L1    26 wing disc CME-W2    52 wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    108 wing disc ML-DmD21    16 wing disc ML-DmD32    97 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    132 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    119 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (77) Schneider line 2 Sg4  (37) embryonic 1182-4H  (108) embryonic GM2  (93) embryonic Kc167  (52) embryonic S1  (309) embryonic S3  (78) leg disc CME L1  26 wing disc CME-W2  (52) wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  (108) wing disc ML-DmD21    16 wing disc ML-DmD32  (97) haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (132) antennal disc ML-DmD20-c5  (134) mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2  (119) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    77 Schneider line 2 Sg4    37 embryonic 1182-4H  108 embryonic GM2    93 embryonic Kc167    52 embryonic S1  (309) embryonic S3    78 leg disc CME L1    26 wing disc CME-W2    52 wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  108 wing disc ML-DmD21    16 wing disc ML-DmD32    97 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  132 antennal disc ML-DmD20-c5  134 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2  119 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    77 Schneider line 2 Sg4    37 embryonic 1182-4H    108 embryonic GM2    93 embryonic Kc167    52 embryonic S1    309 embryonic S3    78 leg disc CME L1    26 wing disc CME-W2    52 wing disc ML-DmD8    3 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    108 wing disc ML-DmD21    16 wing disc ML-DmD32    97 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    132 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    119 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (40) Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult  (30) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult  (28) Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3  (56) Ethanol 10% 3 hrs, larvae L3  (38) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (58) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult  (35) Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (40) Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult  30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult  28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3  (56) Ethanol 10% 3 hrs, larvae L3  (38) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (58) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult  (35) Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GH07453 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020414 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4559-RA;CG4559-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Idgf3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Idgf3GD5407 Phenotype manifest in Allele
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of Idgf3 Class Mutagen Stocks Known lesion Idgf3MB09118 1 -- Idgf3NP2446 1 -- Idgf313 natural population 0 Yes Idgf315 natural population 0 Yes Idgf31 natural population 0 Yes Idgf325 natural population 0 Yes Idgf329 natural population 0 Yes Idgf333 natural population 0 Yes Idgf334 natural population 0 Yes Idgf336 natural population 0 Yes Idgf337 natural population 0 Yes Idgf339 natural population 0 Yes Idgf340 natural population 0 Yes Idgf345 natural population 0 Yes Idgf346 natural population 0 Yes Idgf347 natural population 0 Yes Idgf348 natural population 0 Yes Idgf352 natural population 0 Yes Idgf358 natural population 0 Yes Idgf363 natural population 0 Yes Idgf380 natural population 0 Yes Idgf38 natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Idgf3 Class Mutagen Stocks Known lesion Idgf3GD5407 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Idgf3NIG.4559R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7065 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5407} NA P{NIG.4559R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Idgf3MB09118 No P{GawB}Idgf3NP2446 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
imaginal disc growth factor receptor binding inferred from direct assay (Kawamura et al., 1997) inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Biological Process
CV term Evidence References
imaginal disc development inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
NOT chitinase activity inferred from sequence or structural similarity (assigned by UniProtKB) (Kawamura et al., 1999) chitinase activity inferred from electronic annotation with InterPro:IPR011583 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR001223, InterPro:IPR013781 (FlyBase Curators et al., 2004-) chitin catabolic process inferred from electronic annotation with InterPro:IPR011583 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Idgf3 - CG11911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Idgf3 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0020414
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62NJK9 Dipteran inclusive ortholog search EOG6TF0TN Insect inclusive ortholog search EOG6B5N1J Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG62NJK9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Idgf3     Drosophila simulans   Dsim\Idgf3 Y   Drosophila sechellia   Dsec\GM17179 Y   Drosophila erecta   Dere\GG22750 Y   Drosophila yakuba   Dyak\Idgf3 Y   Drosophila ananassae   Dana\GF13995 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18257 Y   Drosophila persimilis   Dper\GL19639 Y   Drosophila willistoni   Dwil\GK24711 Y   Drosophila virilis   Dvir\GJ22649 Y   Drosophila mojavensis   Dmoj\GI17260 Y   Drosophila grimshawi   Dgri\GH25191 Y
Orthologs in non-Drosophila Dipterans (EOG6TF0TN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001965 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002023 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008060 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008061 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802014 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802013 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802015 Y
Orthologs in non-Dipteran Insects (EOG6B5N1J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52829 Y Apis mellifera Western honey bee  Amel\GB48505 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG024747 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21020 Y Atta cephalotes Leafcutter ant  Acep\ACEP16941 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21654 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20220 Y Linepithema humile Argentine ant  Lhum\LH20042 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16624 Y Solenopsis invicta Red fire ant  Sinv\SINV24111 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001365 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000648 Y Tribolium castaneum Red flour beetle  Tcas\TC013918 Y Tribolium castaneum Red flour beetle  Tcas\TC013917 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Idgf3 Drosophila sechellia Dsec\GM17179 Drosophila erecta Dere\GG22750 Drosophila yakuba Dyak\Idgf3 Drosophila ananassae Dana\GF13995 Drosophila pseudoobscura pseudoobscura Dpse\GA18257 Drosophila persimilis Dper\GL19639 Drosophila willistoni Dwil\GK24711 Drosophila virilis Dvir\GJ22649 Drosophila mojavensis Dmoj\GI17260 Drosophila grimshawi Dgri\GH25191
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	26437 w1118; Mi{ET1}Idgf3MB09118
Kyoto	104205 w*; P{GawB}Idgf3NP2446 / CyO
VDRC	v12423 w1118; P{GD5407}v12423 v12422 w1118; P{GD5407}v12422/TM3
Genomic Clones ( 2 )
	BACR01N08 BACR33A07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 103 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH07453
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05153 AT13828 AT14965 AT17494 GH09372 GH18211 GH20732 GM04853 GM05553 GM07677 HL02712 LP10440 RE21314 RE28275 RE28753 RE46073 RE47507 RE47520 RE62596 RE62616 SD12967 SD23488 SD27774
Other clones	82156 177509 272518 524087 534077 AT02278 bs17d09 CK01.17A.H8 CK01.62A.G8 CK00436 CK00463 EC27334 EC41070 EK049960 EK090209 EK143301 EK158603 EK161907 EK213242 EK282954 EK303507 EN04732 EN10564 ESG014a.E21_B08 ESG015d.B21_F06 ESG017a.E21_D05 ESG017d.E21_A09 ESG018c.E21.1_F08 ESG019c.E21_D12 ESG0110a.E21_A04 ESG0114c.B21_D01 ESG0115d.B21_H05 ESG0119c.B21_D02 RP003040133 RP003046108 RP003046409 RP003057214 RP003082161 RP003090174 RP003137445 RP003204475 RP003217946 RP003226078 RP003259055 RP003274555 RP003284868 RP003289431 RP003293022 RP003299669 RP003302005 RP003323353 RP003329645 RP003330679 RP003343230 RP003356741 RP003399819 RP003422146 RP003456275 RP003474260 RP003495682 RP003498480 RP003501265 RP003504563 RP003506751 RP003529737 RP003534060 RP003542185 RP003554258 RP003556524 RP003557533 RP003560164 RP003574468 RP003577438 RP003582994 RP003602111 RP003636320 RP003649469 RP003653825 RP003681581
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020414 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34981
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Idgf3 CG4559 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) Maps to subclone 3-d7 of P1 DS02780. (Kawamura et al., 1999) Candidate gene for tibia length quantitative trait locus. (Macdonald and Goldstein, 1999) Encodes a soluble growth factor that works in combination with insulin to stimulate cell proliferation, cell polarisation and movement. (Kawamura et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057908 NM_165157 NM_165158 RefSeq (Proteins) • NP_477256 NP_723966 NP_723967 DDBJ / EMBL / GenBank • AA140749 AA695975 AA802437 AAC99419 AAF45018 AAF53537 AAK77293 AAM69645 AAM69646 AAM69647 AAM69648 AAM69649 AAM69650 AAM69651 AAM69652 AAM69653 AAM69654 AAM69655 AAM69656 AAM69657 AAM69658 AAM69659 AAM69660 AAM69661 AAM69662 AAM69663 AAM69664 AAN10940 AAN10941 AC093177 AE003416 AF102238 AF394713 AF394714 AF394715 AF394716 AF394717 AF394718 AF394719 AF394720 AF394721 AF394722 AF394723 AF394724 AF394725 AF394726 AF394727 AF394728 AF394729 AF394730 AF394731 AF394732 AI108968 AI109961 AI402082 AI945837 AY047561 Entrez Gene - A searchable database of RefSeq genes. • 34981 UniProtKB/Swiss-Prot • Q8MLZ7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 18, catalytic domain (IPR001223) Chitinase II (IPR011583) Imaginal disc growth factor (IPR015520) Glycoside hydrolase, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH07453
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0020414 DRSC - Results from RNAi screens. • FBgn0020414 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020414 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4559-RA;CG4559-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020414 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34981 modMine - Data generated by the modENCODE project. • FBgn0020414
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BG:DS02780.2 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4559 (Karlsson et al., 2004, Irving et al., 2001, De Gregorio et al., 2001, Zhu et al., 2004, Mosallanejad et al., 2010) DmIDGF3 (Zhu et al., 2008) IDGF (Britton et al., 1999, Edgar, 2006) IDGF3 (Pappu et al., 2005, Monserrate et al., 2003, Monserrate et al., 2003, Kawamura, 1998.10.28, Hipfner and Cohen, 1999, Kucerova and Zurovec, 2007) IDGF-3 (Varela et al., 2002) idgf3 (Reese et al., 2000, Reese et al., 2000, Moorman et al., 2006) Idgf3 (Morrell et al., 2006, Zurovcova et al., 2006, Zhu et al., 2004, Liu and Lehmann, 2008, Gilchrist et al., 2008, Ayroles et al., 2009, Buchon et al., 2009, Pfeiffer et al., 2008, Nagoshi et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Imaginal disc growth factor 3 (Kawamura et al., 1997) imaginal disc growth factor 3 (Chintapalli et al., 2012)
Secondary FlyBase IDs
References ( 64 )
Generate a list of	All references relating to this gene ( 64 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 9 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 2 )
	Chintapalli et al., 2012, PLoS ONE 7(3): e32577 Functional correlates of positional and gender-specific renal asymmetry in Drosophila. [FBrf0218070] Rotstein et al., 2011, PLoS ONE 6(12): e28985 Tramtrack is genetically upstream of genes controlling tracheal tube size in Drosophila. [FBrf0217085] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...