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Gene Dmel\Idgf1

General Information
Symbol	Dmel\Idgf1	Species	D. melanogaster
Name	Imaginal disc growth factor 1	Annotation symbol	CG4472
Feature type	protein_coding_gene	FlyBase ID	FBgn0020416
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	IDGF, BG:DS02780.5
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	36A1-36A1	Sequence location	2L:16,445,280..16,446,793 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Imaginal disc growth factor 1 is referred to in FlyBase by the symbol Dmel\Idgf1 (CG4472, FBgn0020416). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: imaginal disc growth factor receptor binding. There is experimental evidence that it is involved in the biological process: imaginal disc development. 21 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Chitinase II; Glycoside hydrolase, family 18, catalytic domain; Glycoside hydrolase, subgroup, catalytic domain; Glycoside hydrolase, superfamily; Imaginal disc growth factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult hindgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval hindgut, adult Malpighian tubules, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1633237_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Idgf1. Gene sequence location is 2L:16445280..16446793.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27013 HFA03349
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36A1-36A1   Limits computationally determined from genome sequence between P{EP}fzyEP1028&P{lacW}mRpL4k14608 and P{PZ}dacP
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36A2-36A4     (Kawamura, 1998.10.28) 36A2-36A4     (Kawamura et al., 1997)
Experimentally Determined Recombination Data
Location	2- (Kawamura et al., 1997)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Idgf1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Idgf1-RA FBtr0080860  NM_057910   1443   439
Additional Transcript Data & Comments
Reported size (kB)	1.481 (longest cDNA) (Kawamura et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Idgf1-PA   FBpp0080417   49.4   439   7.28     NP_477258   AAF53535
Additional Polypeptide Data & Comments
Reported size (kDa)	439 (aa) (Kawamura et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 18, catalytic domain (IPR001223) Chitinase II (IPR011583) Imaginal disc growth factor (IPR015520) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA735713   AE014134 AAF53535   AC092398   AE003416 AAF45016   AF102236 AAC99417   AF394691 AAM69623   AF394692 AAM69624   AF394693 AAM69625   AF394694 AAM69626   AF394695 AAM69627   AF394696 AAM69628   AF394697 AAM69629   AF394698 AAM69630   AF394699 AAM69631   AF394700 AAM69632   AF394701 AAM69633   AF394702 AAM69634   AF394703 AAM69635   AF394704 AAM69636   AF394705 AAM69637   AF394706 AAM69638   AF394707 AAM69639   AF394708 AAM69640   AF394709 AAM69641   AF394710 AAM69642   AI063618   AI064422   AI108631   AI109071   AI292999   AI293096   AI296331   AI387590   AI388365   AI389407   AI389428   AI402943   AI405224   AW940692   AY069157 AAL39302   BI165192   BI166047   BI166330   BI167259   BI167812   BI485236   BI580940   BI641738   BP545950   CO155511   CO156216   CO156846   CO156921   CO335722   CO337222   CO337678   EC233517   EC258689   EC262196   EC262466   EC262936   EC264277   EC265930   EC267658   EV597100   GH924395
UniProtKB/Swiss-Prot	Q8MM24
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral furrow | vicinity of   (Kawamura et al., 1999) amnioproctodeal invagination | vicinity of   (Kawamura et al., 1999) embryonic stage & larval stage   embryonic/larval salivary gland   (Kawamura et al., 1999) third instar larval stage   embryonic/larval brain   (Kawamura et al., 1999) ring gland   (Kawamura et al., 1999) imaginal disc   (Kawamura et al., 1999) adult stage & oogenesis   oocyte   (Kawamura et al., 1999) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   cephalic furrow | vicinity of   (Kawamura et al., 1999) embryonic/larval tracheal system   (Kawamura et al., 1999) yolk   (Kawamura et al., 1999) embryonic stage & larval stage   embryonic/larval fat body   (Kawamura et al., 1999) third instar larval stage   embryonic/larval optic lobe   (Kawamura et al., 1999) embryonic/larval lymph gland   (Kawamura et al., 1999) adult stage & oogenesis   nurse cell   (Kawamura et al., 1999)
Additional Descriptive Data
	Idgf1 transcripts are expressed at all stages tested on northern blots but most heavily in mid-larval stages. Idgf1 transcripts are present in the yolk cytoplasm in the early embryo but are excluded from the blastoderm as it cellularizes. During gastrulation, transcripts are observed in rows parallel to the major invaginations including the ventral furrow, the cephalic furrow, and the anterior and posterior midgut invaginations. In late embryos, Idgf1 transcripts are observed in yolk cells, fat body, salivary glands, and in the tracheal system. In third instar larvae, Idgf1 transcripts are strongly expressed in fat body, the ring gland, and in lymph glands. Expression is also observed in the optic lobes, the central brain, and in imaginal discs. Duing oogenesis, Idgf1 transcripts are present in nurse cells and in the oocyte. While the patterns of expression of the four Idgf genes are in general very similar, they are differentially expressed in the larval salivary glands. Levels of Idgf2 and Idgf4 are generally higher than Idgf1 and Idgf3. (Kawamura et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020416    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020416 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020416 expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr    4283 embryo 20-22hr    7660 embryo 22-24hr    10219 larva L1    2400 larva L2    1803 larva L3 12hr old    3231 larva L3 puffstage 1-2    2438 larva L3 puffstage 3-6    1899 larva L3 puffstage 7-9    2298 white prepupae new    2787 white prepupae 12hr    1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP    4133 adult male 01day    1935 adult male 05day    1466 adult male 30day    1451 adult female 01day    1294 adult female 05day    1454 adult female 30day    2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr  (167) embryo 16-18hr  (1228) embryo 18-20hr  (4283) embryo 20-22hr  (7660) embryo 22-24hr  (10219) larva L1  (2400) larva L2  (1803) larva L3 12hr old  (3231) larva L3 puffstage 1-2  (2438) larva L3 puffstage 3-6  (1899) larva L3 puffstage 7-9  (2298) white prepupae new  (2787) white prepupae 12hr  (1863) white prepupae 24hr  (371) pupae 2d postWPP  (500) pupae 3d postWPP  (295) pupae 4d postWPP  (4133) adult male 01day  (1935) adult male 05day  (1466) adult male 30day  (1451) adult female 01day  (1294) adult female 05day  (1454) adult female 30day  (2148) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr  (4283) embryo 20-22hr  (7660) embryo 22-24hr  (10219) larva L1  (2400) larva L2  (1803) larva L3 12hr old  (3231) larva L3 puffstage 1-2  (2438) larva L3 puffstage 3-6  (1899) larva L3 puffstage 7-9  (2298) white prepupae new  (2787) white prepupae 12hr  (1863) white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP  (4133) adult male 01day  (1935) adult male 05day  1466 adult male 30day  1451 adult female 01day    1294 adult female 05day  1454 adult female 30day  (2148) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr    4283 embryo 20-22hr    7660 embryo 22-24hr  10219 larva L1    2400 larva L2    1803 larva L3 12hr old    3231 larva L3 puffstage 1-2    2438 larva L3 puffstage 3-6    1899 larva L3 puffstage 7-9    2298 white prepupae new    2787 white prepupae 12hr    1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP    4133 adult male 01day    1935 adult male 05day    1466 adult male 30day    1451 adult female 01day    1294 adult female 05day    1454 adult female 30day    2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr    4283 embryo 20-22hr    7660 embryo 22-24hr    10219 larva L1    2400 larva L2    1803 larva L3 12hr old    3231 larva L3 puffstage 1-2    2438 larva L3 puffstage 3-6    1899 larva L3 puffstage 7-9    2298 white prepupae new    2787 white prepupae 12hr    1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP    4133 adult male 01day    1935 adult male 05day    1466 adult male 30day    1451 adult female 01day    1294 adult female 05day    1454 adult female 30day    2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020416 expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr    4283 embryo 20-22hr    7660 embryo 22-24hr    10219 larva L1    2400 larva L2    1803 larva L3 12hr old    3231 larva L3 puffstage 1-2    2438 larva L3 puffstage 3-6    1899 larva L3 puffstage 7-9    2298 white prepupae new    2787 white prepupae 12hr    1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP    4133 adult male 01day    1935 adult male 05day    1466 adult male 30day    1451 adult female 01day    1294 adult female 05day    1454 adult female 30day    2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr  (167) embryo 16-18hr  (1228) embryo 18-20hr  (4283) embryo 20-22hr  (7660) embryo 22-24hr  (10219) larva L1  (2400) larva L2  (1803) larva L3 12hr old  (3231) larva L3 puffstage 1-2  (2438) larva L3 puffstage 3-6  (1899) larva L3 puffstage 7-9  (2298) white prepupae new  (2787) white prepupae 12hr  (1863) white prepupae 24hr  (371) pupae 2d postWPP  (500) pupae 3d postWPP  (295) pupae 4d postWPP  (4133) adult male 01day  (1935) adult male 05day  (1466) adult male 30day  (1451) adult female 01day  (1294) adult female 05day  (1454) adult female 30day  (2148) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr  (4283) embryo 20-22hr  (7660) embryo 22-24hr  (10219) larva L1  2400 larva L2  1803 larva L3 12hr old  (3231) larva L3 puffstage 1-2  2438 larva L3 puffstage 3-6  1899 larva L3 puffstage 7-9  2298 white prepupae new  (2787) white prepupae 12hr  1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP  (4133) adult male 01day  1935 adult male 05day  1466 adult male 30day  1451 adult female 01day    1294 adult female 05day  1454 adult female 30day  2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr    4283 embryo 20-22hr    7660 embryo 22-24hr  10219 larva L1    2400 larva L2    1803 larva L3 12hr old    3231 larva L3 puffstage 1-2    2438 larva L3 puffstage 3-6    1899 larva L3 puffstage 7-9    2298 white prepupae new    2787 white prepupae 12hr    1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP    4133 adult male 01day    1935 adult male 05day    1466 adult male 30day    1451 adult female 01day    1294 adult female 05day    1454 adult female 30day    2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    4 embryo 04-06hr    5 embryo 06-08hr    13 embryo 08-10hr    35 embryo 10-12hr    27 embryo 12-14hr    31 embryo 14-16hr    167 embryo 16-18hr    1228 embryo 18-20hr    4283 embryo 20-22hr    7660 embryo 22-24hr    10219 larva L1    2400 larva L2    1803 larva L3 12hr old    3231 larva L3 puffstage 1-2    2438 larva L3 puffstage 3-6    1899 larva L3 puffstage 7-9    2298 white prepupae new    2787 white prepupae 12hr    1863 white prepupae 24hr    371 pupae 2d postWPP    500 pupae 3d postWPP    295 pupae 4d postWPP    4133 adult male 01day    1935 adult male 05day    1466 adult male 30day    1451 adult female 01day    1294 adult female 05day    1454 adult female 30day    2148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020416    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020416 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult hindgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval hindgut, adult Malpighian tubules, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020416 expression level Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body    1300.4 Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head    597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut    699.7 Adult Malpighian Tubules    401.5 Adult Fat Body    1503.4 Adult Salivary Gland    75.9 Adult Heart    1230.6 Adult VirginFemale Spermatheca    1689.5 Adult InseminatedFemale Spermatheca    1409.2 Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass    696.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body  (1300.4) Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head  (597.7) Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut  (699.7) Adult Malpighian Tubules    401.5 Adult Fat Body  (1503.4) Adult Salivary Gland    75.9 Adult Heart  (1230.6) Adult VirginFemale Spermatheca  (1689.5) Adult InseminatedFemale Spermatheca  (1409.2) Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass  (696.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body  (1300.4) Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head    597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut    699.7 Adult Malpighian Tubules    401.5 Adult Fat Body  (1503.4) Adult Salivary Gland    75.9 Adult Heart  (1230.6) Adult VirginFemale Spermatheca  (1689.5) Adult InseminatedFemale Spermatheca  (1409.2) Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass    696.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body    1300.4 Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head    597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut    699.7 Adult Malpighian Tubules    401.5 Adult Fat Body    1503.4 Adult Salivary Gland    75.9 Adult Heart    1230.6 Adult VirginFemale Spermatheca    1689.5 Adult InseminatedFemale Spermatheca    1409.2 Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass    696.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020416 expression level Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body    1300.4 Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head    597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut    699.7 Adult Malpighian Tubules    401.5 Adult Fat Body    1503.4 Adult Salivary Gland    75.9 Adult Heart    1230.6 Adult VirginFemale Spermatheca    1689.5 Adult InseminatedFemale Spermatheca    1409.2 Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass    696.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body  (1300.4) Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head  597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut  699.7 Adult Malpighian Tubules    401.5 Adult Fat Body  (1503.4) Adult Salivary Gland    75.9 Adult Heart  (1230.6) Adult VirginFemale Spermatheca  (1689.5) Adult InseminatedFemale Spermatheca  (1409.2) Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass  696.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body  1300.4 Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head    597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut    699.7 Adult Malpighian Tubules    401.5 Adult Fat Body  1503.4 Adult Salivary Gland    75.9 Adult Heart  1230.6 Adult VirginFemale Spermatheca  1689.5 Adult InseminatedFemale Spermatheca  1409.2 Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass    696.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.975 Larval Midgut    4.3 Larval Hindgut    254.9 Larval Malpighian Tubules    78.9 Larval Fat Body    1300.4 Larval Salivary Gland no informative data Larval Trachea    46.6 Larval Carcass    114.3 Adult Head    597.7 Adult Eye    323.475 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    25.2 Adult Crop    358.1 Adult Midgut no informative data Adult Hindgut    699.7 Adult Malpighian Tubules    401.5 Adult Fat Body    1503.4 Adult Salivary Gland    75.9 Adult Heart    1230.6 Adult VirginFemale Spermatheca    1689.5 Adult InseminatedFemale Spermatheca    1409.2 Adult Ovary    5.1 Adult Testis no informative data Adult Male Accessory Gland    4.1 Adult Carcass    696.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    597.7   NA  Eye    323.475   NA  Brain    27.1   5.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25.2   NA  Crop    358.1   4.3  Midgut    no informative data   254.9  Hindgut    699.7   78.9  Malpighian Tubules    401.5   1300.4  Fat Body    1503.4   no informative data  Salivary Gland    75.9   NA  Heart    1230.6   46.6  Trachea    NA   NA  VirginFemale Spermatheca    1689.5   NA  InseminatedFemale Spermatheca    1409.2   NA  Ovary    5.1   NA  Testis    no informative data   NA  Male Accessory Gland    4.1   114.3  Carcass    696.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020416 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4472-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Idgf1GD5405 Phenotype manifest in Allele
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of Idgf1 Class Mutagen Stocks Known lesion Idgf113 natural population 0 Yes Idgf115 natural population 0 Yes Idgf11 natural population 0 Yes Idgf125 natural population 0 Yes Idgf129 natural population 0 Yes Idgf133 natural population 0 Yes Idgf134 natural population 0 Yes Idgf136 natural population 0 Yes Idgf137 natural population 0 Yes Idgf139 natural population 0 Yes Idgf140 natural population 0 Yes Idgf145 natural population 0 Yes Idgf146 natural population 0 Yes Idgf147 natural population 0 Yes Idgf148 natural population 0 Yes Idgf152 natural population 0 Yes Idgf158 natural population 0 Yes Idgf163 natural population 0 Yes Idgf180 natural population 0 Yes Idgf18 natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Idgf1 Class Mutagen Stocks Known lesion Idgf1GD5405 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7065 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5405} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
imaginal disc growth factor receptor binding inferred from direct assay (Kawamura et al., 1997) inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Biological Process
CV term Evidence References
imaginal disc development inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Kawamura et al., 1999)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cation binding inferred from electronic annotation with InterPro:IPR013781 (FlyBase Curators et al., 2004-) NOT chitinase activity inferred from sequence or structural similarity (assigned by UniProtKB) (Kawamura et al., 1999) chitinase activity inferred from electronic annotation with InterPro:IPR011583 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
chitin catabolic process inferred from electronic annotation with InterPro:IPR011583 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Idgf1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0020416
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13993 Dere\GG22747 Dmoj\GI17258 Dper\GL19637 Dpse\GA18209 Dsec\GM17177 Dsim\Idgf1 Dvir\GJ22627 Dwil\GK24709 Dyak\Idgf1
Curated drosophilid orthologs	Dpse\GA18209   Dsim\Idgf1 (Zurovcova and Ayala, 2001) Dyak\Idgf1 (Zurovcova and Ayala, 2001)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0044136 FBgn0226669 FBgn0209731 FBgn0044200 FBgn0172088 FBgn0078216 FBgn0157235 FBgn0140002 FBgn0132644 FBgn0131083 FBgn0130987 FBgn0114912 FBgn0091020
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v12414 w1118; P{GD5405}v12414 v12416 w1118; P{GD5405}v12416
Genomic Clones ( 2 )
	BACR01N08 BACR33A07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH18152
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03533 GH04843 GH07581 GH07837 GH16059 GH16186 GH19247 GH20570 GH20594 GH22283 GH25164 GM09616 LP10192 RE05030 RE06067 RE06425 RE07603 RE08285 RE68533 RE75190 SD25318
Other clones	35090 214413.25 524943 528302 533466 542667 569521 Dmel_neb_015613_0932_2784 EN06225 EN07602 EN09426 EN09558 EN11054 EN14063 EN15051 FGH101C05 RP003346649
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020416 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34978
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Idgf1 CG4472 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Maps to subclone 8-f9 of P1 DS02780. (Kawamura et al., 1999) Candidate gene for tibia length quantitative trait locus. (Macdonald and Goldstein, 1999) Encodes a soluble growth factor that works in combination with insulin to stimulate cell proliferation, cell polarisation and movement. (Kawamura et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057910 RefSeq (Proteins) • NP_477258 DDBJ / EMBL / GenBank • AA735713 AAC99417 AAF45016 AAF53535 AAL39302 AAM69623 AAM69624 AAM69625 AAM69626 AAM69627 AAM69628 AAM69629 AAM69630 AAM69631 AAM69632 AAM69633 AAM69634 AAM69635 AAM69636 AAM69637 AAM69638 AAM69639 AAM69640 AAM69641 AAM69642 AC092398 AE003416 AF102236 AF394691 AF394692 AF394693 AF394694 AF394695 AF394696 AF394697 AF394698 AF394699 AF394700 AF394701 AF394702 AF394703 AF394704 AF394705 AF394706 AF394707 AF394708 AF394709 AF394710 AI063618 AI064422 AI108631 AI109071 AI387590 AW940692 AY069157 Entrez Gene - A searchable database of RefSeq genes. • 34978 UniProtKB/Swiss-Prot • Q8MM24
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 18, catalytic domain (IPR001223) Chitinase II (IPR011583) Imaginal disc growth factor (IPR015520) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0020416 DRSC - Results from RNAi screens. • FBgn0020416 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020416 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4472-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020416 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34978 modMine - Data generated by the modENCODE project. • FBgn0020416 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0044136 FBgn0226669 FBgn0209731 FBgn0044200 FBgn0172088 FBgn0078216 FBgn0157235 FBgn0140002 FBgn0132644 FBgn0131083 FBgn0130987 FBgn0114912 FBgn0091020
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BG:DS02780.5 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4472 (Kang et al., 2002, De Gregorio et al., 2001, Zhu et al., 2004, Riedl et al., 2005) DmIDGF1 (Zhu et al., 2008) IDGF (Edgar, 2006, Britton et al., 1999) IDGF1 (Monserrate et al., 2003, Monserrate et al., 2003, Kawamura, 1998.10.28, Hipfner and Cohen, 1999, Kucerova and Zurovec, 2007) IDGF-1 (Varela et al., 2002) idgf1 (Reese et al., 2000, Reese et al., 2000, Negre et al., 2006) Idgf1 (Morrell et al., 2006, Zurovcova et al., 2006, Zhu et al., 2004, Georlette et al., 2007, Kwon et al., 2008, Ayroles et al., 2009, Buchon et al., 2009, Lai et al., 2007, Bina et al., 2010, Seong et al., 2011, Riedl et al., 2005)
Name Synonym	Imaginal disc growth factor1 (Kang et al., 2002) Imaginal disc growth factor 1 (Kawamura et al., 1997, Negre et al., 2006, Lai et al., 2007, Harbison et al., 2005)
Secondary FlyBase IDs
	FBgn0027915
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Bina et al., 2010, EMBO Rep. 11(3): 201--207 Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. [FBrf0210131] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...