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Gene Dmel\GluRIIB

General Information
Symbol	Dmel\GluRIIB	Species	D. melanogaster
Name	Glutamate receptor IIB	Annotation symbol	CG7234
Feature type	protein_coding_gene	FlyBase ID	FBgn0020429
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	dglurIIB
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25E6-25E6	Sequence location	2L:5,559,342..5,563,502 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Glutamate receptor IIB is referred to in FlyBase by the symbol Dmel\GluRIIB (CG7234, FBgn0020429). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: ion transport. 13 alleles are reported. The phenotype of these alleles is annotated with: neuromuscular junction. It has one annotated transcript and one annotated polypeptide. Protein features are: Extracellular ligand-binding receptor; Extracellular solute-binding protein, family 3; Glutamate receptor, L-glutamate/glycine-binding; Ionotropic glutamate receptor; NMDA receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1625654_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of GluRIIB. Gene sequence location is 2L:5559342..5563502.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Insertions Mi{MIC}GluRIIB[MI03631]a Mi{MIC}GluRIIB[MI03631]b Alleles GluRIIB[MI03631] Sequence features BKN25825 HFA03335 References Bellen, 2011.10.25, set956.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25E6-25E6   Limits computationally determined from genome sequence between P{lacW}Hel25Ek11511 and P{lacW}l(2)k06502k06502
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25F-25F     (Petersen, 1998.1.20) 25F-25F   (determined by in situ hybridisation)   (Petersen et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\GluRIIB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone SD17808 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) GluRIIB-RI FBtr0089577  NM_078761   2949   913
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein GluRIIB-PI   FBpp0088541   104.3   913   6.38     NP_523485   AAF52269
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	Antibody raised to C-terminal peptide -ASSAKKKKKTRRIEK (Marrus et al., 2004)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320) NMDA receptor (IPR001508) Extracellular ligand-binding receptor (IPR001828) Extracellular solute-binding protein, family 3 (IPR001638) Glutamate receptor, L-glutamate/glycine-binding (IPR019594)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52269   AF044202 AAC00192   BI636198   CS133221   EY198608   FE527367   FE527370   FE527552   FE527620   FL502850
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O45028 Q9VMP3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
epitope tag Stage Tissue/Position (including subcellular localization) Reference embryonic stage 17   embryonic/larval neuromuscular junction   (Saitoe et al., 2001) immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   somatic muscle   • neuromuscular junction (Marrus et al., 2004) somatic muscle   • type I terminal button (Marrus et al., 2004) somatic muscle   • type Is terminal button (Marrus et al., 2004) somatic muscle   • type Ib terminal button (Marrus et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020429    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020429 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020429 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr  (292) embryo 12-14hr  (502) embryo 14-16hr  (328) embryo 16-18hr  (309) embryo 18-20hr  (258) embryo 20-22hr  (272) embryo 22-24hr  (334) larva L1  (182) larva L2  (141) larva L3 12hr old  (120) larva L3 puffstage 1-2  (115) larva L3 puffstage 3-6  (217) larva L3 puffstage 7-9  (170) white prepupae new  105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020429 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr  (292) embryo 12-14hr  (502) embryo 14-16hr  (328) embryo 16-18hr  (309) embryo 18-20hr  (258) embryo 20-22hr  (272) embryo 22-24hr  (334) larva L1  (182) larva L2  141 larva L3 12hr old  120 larva L3 puffstage 1-2  115 larva L3 puffstage 3-6  (217) larva L3 puffstage 7-9  (170) white prepupae new  105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    10 embryo 04-06hr    2 embryo 06-08hr    16 embryo 08-10hr    33 embryo 10-12hr    292 embryo 12-14hr    502 embryo 14-16hr    328 embryo 16-18hr    309 embryo 18-20hr    258 embryo 20-22hr    272 embryo 22-24hr    334 larva L1    182 larva L2    141 larva L3 12hr old    120 larva L3 puffstage 1-2    115 larva L3 puffstage 3-6    217 larva L3 puffstage 7-9    170 white prepupae new    105 white prepupae 12hr    29 white prepupae 24hr    41 pupae 2d postWPP    31 pupae 3d postWPP    16 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    13 adult male 30day    19 adult female 01day    14 adult female 05day    6 adult female 30day    8 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020429    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020429 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020429 expression level Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020429 expression level Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    12.175 Larval Midgut no informative data Larval Hindgut    25.5 Larval Malpighian Tubules    14.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.925 Larval Carcass    73.4 Adult Head    9.9 Adult Eye    4.9 Adult Brain    9.8 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    17.9 Adult Midgut    9.5 Adult Hindgut    22.9 Adult Malpighian Tubules no informative data Adult Fat Body    22.2 Adult Salivary Gland no informative data Adult Heart    16.225 Adult VirginFemale Spermatheca    23.8 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    9.9   NA  Eye    4.9   NA  Brain    9.8   12.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.8   NA  Crop    17.9   no informative data  Midgut    9.5   25.5  Hindgut    22.9   14.4  Malpighian Tubules    no informative data   no informative data  Fat Body    22.2   no informative data  Salivary Gland    no informative data   NA  Heart    16.225   6.925  Trachea    NA   NA  VirginFemale Spermatheca    23.8   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    5.6   NA  Testis    6.5   NA  Male Accessory Gland    no informative data   73.4  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020429 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7234-RI
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 GluRIIBGD917 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4Mhc.PW GluRIIBScer\UAS.cDa neurophysiology defective GluRIIBunspecified neurophysiology defective | larval stage GluRIIBMhc.T:Hsap\MYC wild-type GluRIIB+tg GluRIIBMhc.PD Phenotype manifest in Allele neuromuscular junction GluRIIBMhc.PD neuromuscular junction, with Scer\GAL4how-24B GluRIIBScer\UAS.cDa neuromuscular junction, with Scer\GAL4Mhc.PW GluRIIBScer\UAS.cDa neuromuscular junction | larval stage GluRIIBMhc.T:Hsap\MYC neuromuscular junction | larval stage, with Scer\GAL4Mhc.PW GluRIIBScer\UAS.cDa
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of GluRIIB Class Mutagen Stocks Known lesion GluRIIBAD1 P-element activity 0 Yes GluRIIBMI03631 0 -- GluRIIBunspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of GluRIIB Class Mutagen Stocks Known lesion GluRIIBGD917 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GluRIIBJF03145 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GluRIIBKK105825 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GluRIIB+t.cSa in vitro construct - genomic fragment 0 Yes GluRIIB+tg in vitro construct - genomic fragment 0 Yes GluRIIBGluRIIA.CTD.T:Avic\GFP-EGFP in vitro construct - genomic fragment in vitro construct - coding region fusion 0 Yes GluRIIBMhc.PD in vitro construct - regulatory fusion 0 Yes GluRIIBMhc.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes GluRIIBScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes GluRIIBT:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)cl-h4 (Sigrist et al., 2002) Df(2L)Exel6256 (Ryder, 2004.4.26) Df(2L)Exel7023 (Ryder, 2004.4.26) Df(2L)Exel8016 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD917} NA P{KK105825} NA P{TRiP.JF03145} NA P{UAS-GluRIIB.D} NA characterization construct P{GluRIIB.+t} NA P{GluRIIB.CTDGluRIIA-GFP} NA P{GluRIIB.GFP} NA P{GluRIIB+g} NA P{Mhc.GluRIIB.D} NA P{Mhc.GluRIIB.Myc} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}GluRIIBMI03631a NA Mi{MIC}GluRIIBMI03631b NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity inferred from direct assay (Petersen et al., 1997) glutamate receptor activity inferred from direct assay (DiAntonio et al., 1997)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
neuromuscular junction inferred from direct assay (Karr et al., 2009, Kohsaka et al., 2007) colocalizes_with postsynaptic membrane inferred from direct assay (Kohsaka et al., 2007)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
extracellular-glutamate-gated ion channel activity inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR001508, InterPro:IPR019594 (FlyBase Curators et al., 2004-) kainate selective glutamate receptor activity inferred from sequence or structural similarity (Littleton and Ganetzky, 2000)
Biological Process
CV term Evidence References
ion transport inferred from electronic annotation with InterPro:IPR001508 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
outer membrane-bounded periplasmic space inferred from electronic annotation with InterPro:IPR001638 (FlyBase Curators et al., 2004-) plasma membrane inferred from sequence or structural similarity with GluRIIA (Petersen et al., 1997)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions GluRIIB allele Gene References GluRIIBScer\UAS.cDa GluRIIA (Sigrist et al., 2002) unspecified GluRIIA (DiAntonio et al., 1997)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0020429
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH11035 Dmoj\GI17554 Dvir\GJ15540 Dwil\GK14684
Curated drosophilid orthologs	Dpse\GA20200
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0242592 FBgn0216690 FBgn0202733 FBgn0194739 FBgn0173469 FBgn0080195 FBgn0163951 FBgn0140298 FBgn0118516 FBgn0117214 FBgn0092598
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28718 y1 v1; P{TRiP.JF03145}attP2
VDRC	v105581 P{KK105825}VIE-260B v7878 w1118; P{GD917}v7878
Genomic Clones ( 1 )
	BACR35L07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG3-chr2L.639.pred.a DMG4-chr2L.10.010.pred.a SD17808
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020429 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33789
Antibody Information
	polyclonal (Marrus et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: GluRIIB CG7234 (Skupski, 1999.11)
Source for database merge of
Additional comments
Other Comments
	GluRIIC is required for synaptic localisation of GluRIIA and GluRIIB proteins. Either GluRIIA or GluRIIB, but not both, is required for synaptic localisation of GluRIIC protein. GluRIIA and GluRIIB proteins compete with each other for access to GluRIIC protein and subsequent localisation to the synapse. (Marrus et al., 2004) Animals doubly mutant for GluRIIA and GluRIIB show late embryonic lethality, which can be rescued by transgenes expressing either gene alone. (DiAntonio et al., 1997) Glutamate receptor channels in Drosophila embryos and larvae have been studied using the patch-clamp technique. (Nishikawa and Kidokoro, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078761 RefSeq (Proteins) • NP_523485 DDBJ / EMBL / GenBank • AAC00192 AAF52269 AF044202 BI636198 CS133221 Entrez Gene - A searchable database of RefSeq genes. • 33789 UniProtKB/TrEMBL • O45028 Q9VMP3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320) NMDA receptor (IPR001508) Extracellular ligand-binding receptor (IPR001828) Extracellular solute-binding protein, family 3 (IPR001638) Glutamate receptor, L-glutamate/glycine-binding (IPR019594)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0020429 DRSC - Results from RNAi screens. • FBgn0020429 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020429 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7234-RI FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020429 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33789 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/glutrc1.htm modMine - Data generated by the modENCODE project. • FBgn0020429 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0242592 FBgn0216690 FBgn0202733 FBgn0194739 FBgn0173469 FBgn0080195 FBgn0163951 FBgn0140298 FBgn0118516 FBgn0117214 FBgn0092598
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG7234 (Benton et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009) DGluIIB (DiAntonio et al., 1997) dglurIIB (Sigrist et al., 2002) dGluRIIB (Ma et al., 2001) DGluRIIB (Griffith, 2004, Marrus et al., 2004, Saitoe et al., 2001, Petersen, 1998.1.20, DiAntonio et al., 1999, Davis and Goodman, 1998, Davis et al., 1998, Petersen et al., 1997, Rivlin et al., 2004, van der Plas et al., 2006, Guerrero et al., 2005, Wairkar et al., 2008, Lee et al., 2008, Owald et al., 2010) DGluR-IIB (Saitoe et al., 2001) glurIIB (Featherstone et al., 2001) GluRIIb (Krishnan et al., 2001) Glu-RIIB   GluRIIB (Augustin et al., 2007, Haas et al., 2007, Chen et al., 2005, Rasse et al., 2005, Schmid et al., 2006, Kohsaka et al., 2007, Pan and Broadie, 2007, Benton et al., 2009, Chen and Featherstone, 2005, Giagtzoglou et al., 2009, Schmid et al., 2008, Karr et al., 2009, Ramachandran et al., 2009, Chai et al., 2008, Chen et al., 2010, Higashi-Kovtun et al., 2010, Wang et al., 2010, Croset et al., 2010, Morimoto et al., 2010, Pilgram et al., 2011, Sun et al., 2011, Wang et al., 2011) unnamed (Landmesser, 1998, Nishikawa and Kidokoro, 1995)
Name Synonym	glutamate receptor (Verstreken and Bellen, 2002) Glutamate receptor IIB
Secondary FlyBase IDs
References ( 68 )
Generate a list of	All references relating to this gene ( 68 )
List References by type	Research paper  ( 46 ) Supplementary material  ( 3 ) Review  ( 5 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 9 )
	Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Sun et al., 2011, J. Neurosci. 31(2): 687--699 Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. [FBrf0212770] Wang et al., 2011, J. Neurosci. 31(8): 2868--2877 Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an alexander disease model. [FBrf0213281] Chen et al., 2010, PLoS ONE 5(6): e11115 Neurexin in embryonic Drosophila neuromuscular junctions. [FBrf0211087] Croset et al., 2010, PLoS Genet. 6(8): Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681] Higashi-Kovtun et al., 2010, J. Neurosci. 30(15): 5253--5268 Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. [FBrf0210588] Morimoto et al., 2010, Neuroscience 165(4): 1284--1292 Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neuromuscular junctions. [FBrf0209866] Owald et al., 2010, J. Cell Biol. 188(4): 565--579 A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. [FBrf0210057] Wang et al., 2010, J. Cell Sci. 123(9): 1546--1556 Drosophila twinfilin is required for cell migration and synaptic endocytosis. [FBrf0210650] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...