FlyBase Gene Report: Dmel\eRF3

General Information

Symbol

Dmel\eRF3

Species

D. melanogaster

Name

eukaryotic translation release factor 3

Annotation Symbol

CG6382

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020443

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

eukaryotic translation release factor 3 (eRF3) encodes a GTP-binding protein important in the termination of protein translation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Elf, Dsup35, delf

Key Links

Genomic Location

Cytogenetic map

33E4-33E5

Sequence location

2L:12,434,452..12,441,279 [+]

Recombination map

2-46

RefSeq locus

NT_033779 REGION:12434452..12441279

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables GTP binding

inferred from sequence or structural similarity

(Chao et al., 2003)

inferred from electronic annotation with InterPro:IPR000795, InterPro:IPR004161

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from electronic annotation with InterPro:IPR000795

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000561878

(GO Reference Genome Project, 2011-)

enables translation release factor activity

inferred from biological aspect of ancestor with PANTHER:PTN000562411

(GO Reference Genome Project, 2011-)

enables translation termination factor activity

inferred from sequence or structural similarity

(Lasko, 2000)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in translational termination

inferred from mutant phenotype

(Chao et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in translation

inferred from biological aspect of ancestor with PANTHER:PTN000561878

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of translation release factor complex

inferred from biological aspect of ancestor with PANTHER:PTN000562411

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CYTOPLASMIC TRANSLATION RELEASE FACTORS

TRANSLATIONAL GTPASES

ERF1-ERF3 TRANSLATION TERMINATION COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Snapshot

eukaryotic translation release factor 3 (eRF3) encodes a GTP-binding protein important in the termination of protein translation. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

CYTOPLASMIC TRANSLATION RELEASE FACTORS -: Cytoplasmic (or eukaryotic) translation termination (or release) factors catalyze the release of the nascent polypeptide chain from ribosomes in the cytoplasm. (Adapted from FBrf0233552 and PMID:22751155).
TRANSLATIONAL GTPASES -: Translational GTPases are a family of GTPases that facilitate and control protein synthesis on the ribosome. (Adapted from PMID:26971860).
ERF1-ERF3 TRANSLATION TERMINATION COMPLEX -: The ERF1-ERF3 translation termination complex is required for the termination of protein synthesis which occurs when one of three stop codons (UAA, UAG or UGA) enters the ribosomal A site. eRF1 stimulates GTP binding to eRF3, inducing the GTPase activity of eRF3 that couples codon recognition and peptidyl-tRNA hydrolysis mediated by eRF1 to ensure rapid and efficient peptide release on the ribosome. (Adapted from ComplexPortal.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\eRF3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VK85)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

eRF3-RA

FBtr0080369

NM_057911

3443

619

eRF3-RB

FBtr0333089

NM_001273486

4120

619

eRF3-RC

FBtr0333090

NM_001273487

2760

495

eRF3-RD

FBtr0344859

NM_001298945

3003

619

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

eRF3-PA

FBpp0079951

66.5

619

4.99

FBpp0305302

66.5

619

4.99

FBpp0305303

55.3

495

7.21

FBpp0311174

66.5

619

4.99

Q9VK85

NP_001285874

AHN54388

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

619 aa isoforms: eRF3-PA, eRF3-PB, eRF3-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

619 (aa); 85 (kD observed); 66 (kD predicted)

(Basu et al., 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eRF3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

spermatid

(Basu et al., 1998)

spermatogonium

(Basu et al., 1998)

spermatocyte

(Basu et al., 1998)

testis

(Basu et al., 1998)

Additional Descriptive Data

elf protein is primarily detected in the testis in adult males on Western blots though some is also present in the residual carcasses. It is detected by immunolocalization as low level, nonuniform staining throughout the spermatogonia, the spermatocytes, and the spermatids. In mature primary spermatocytes, staining is observed in single discrete spots within the nuclei of most primary spermatocytes. In a few, a pair of intense spots is seen.

(Basu et al., 1998)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}eRF3^CPTI000609

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\eRF3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eRF3

View exonic expression by tissue for Dmel\eRF3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020443

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34658/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020443

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020443

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020443

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6382

Flygut - An atlas of the Drosophila adult midgut

FBgn0020443

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\eRF3

Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eRF3

Transgenic constructs containing regulatory region of eRF3

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)BSC407

(Christensen et al., 2008.4.15)

Df(2L)ED776

(Marygold et al., 2007)

Df(2L)Exel6033

(Marygold et al., 2007, Ryder, 2004.4.26)

Df(2L)prd1.7

(Chao et al., 2003)

Df(2L)Prl

(Harris et al., 2003, Spradling et al., 1999, Basu et al., 1998, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2L)prd1.7

(BDGP Project Members, 1994-1999)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

eRF3^k06909

lethal - all die before end of larval stage | recessive

eRF3^LR16

viable

Sterility

Allele

fertile

eRF3^EY12435

male sterile

eRF3^63D

Other Phenotypes

Allele

abnormal cytokinesis

eRF3^63D

some die during larval stage | recessive

eRF3^LR16

Phenotype manifest in

Allele

aster

eRF3^63D

Nebenkern

eRF3^63D

onion stage spermatid

eRF3^63D

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\GSPT1

13 of 14

Yes

Hsap\GSPT2

12 of 14

Yes

4 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Gspt1

13 of 14

Yes

Rnor\Gspt2

12 of 14

Yes

4 of 14

4 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Gspt1

13 of 14

Yes

Mmus\Gspt2

12 of 14

Yes

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\gspt1

8 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (17)

Drer\gspt1

13 of 14

Yes

Drer\gspt1l

12 of 14

Yes

5 of 14

4 of 14

4 of 14

4 of 14

3 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\erfa-3

12 of 14

Yes

4 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP009310

12 of 12

Yes

4 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (21)

Atha\AT1G18070

13 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

2 of 13

Yes

Atha\AT1G35550

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\SUP35

13 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\sup35

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

1 of 12

Yes

Spom\tif213

1 of 12

Spom\tuf1

1 of 12

Escherichia coli (enterobacterium) (4)

Ecol\cysN

5 of 11

Yes

Ecol\selB

1 of 11

Ecol\tufA

1 of 11

Ecol\tufB

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:eRF3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

9 of 13

9 of 13

8 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

waw

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

eRF3^EY12435

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GSPT1; G1 to S phase transition 1

13 of 14

139259

GSPT2; G1 to S phase transition 2

12 of 14

300418

EEF1A2; eukaryotic translation elongation factor 1 alpha 2

4 of 14

602959

EEF1A1; eukaryotic translation elongation factor 1 alpha 1

3 of 14

130590

HBS1L; HBS1 like translational GTPase

3 of 14

612450

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

eRF3 - Lipt2

experimental knowledge based

(Guruharsha et al., 2011)

eRF3 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

eRF3

(Chao et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60705

DroID - A comprehensive database of gene and protein interactions.

FBgn0020443

MIST (protein-protein) - An integrated Molecular Interaction Database

34658

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-46

Cytogenetic map

33E4-33E5

Sequence location

2L:12,434,452..12,441,279 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33E4-33E5

Limits computationally determined from genome sequence between P{PZ}Rab6⁰⁸³²³ and P{EP}Elf^EP476&P{EP}bun^EP488

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

33E7-33E9

(Basu, 1997.2.6, Basu et al., 1997)

33E5-33E7

(determined by in situ hybridisation)

(Spradling et al., 1999)

33E7-33E9

(determined by in situ hybridisation)

(Basu et al., 1998, Basu, 1997.4.19)

33E5-33E7

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-46

(FlyBase, 2016)

2-40.9

(Comeron et al., 2012)

(Chao et al., 2003)

Left of (cM)

Right of (cM)

Notes

Maps very close to b.

(Chao et al., 2003)

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

7067

eRF3^LR16 pr¹/CyO

13928

y¹; P{SUPor-P}eRF3^KG02116

81488

y¹ v¹; P{TKO.GS04818}attP40

20740

y¹ w^67c23; P{EPgy2}eRF3^EY12435

10648

y¹ w^67c23; P{lacW}eRF3^k06909/CyO

36703

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01592}attP2

Kyoto

124504

w¹¹¹⁸; P{RS3}eRF3^UM-8369-3

125101

w¹¹¹⁸; P{RS5}eRF3^5-HA-1140

115113

w¹¹¹⁸; PBac{602.P.SVS-1}eRF3^CPTI000609

NIG-Fly

M2L-1652

y¹ w¹¹¹⁸; eRF3^SK4 P{neoFRT}40A/CyO-Tb

M2L-1653

y¹ w¹¹¹⁸; eRF3^SK8 P{neoFRT}40A/CyO-Tb

VDRC

v106240

P{KK100758}VIE-260B

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (111)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE07731

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020443

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020443

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Basu et al., 1998)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mutations in Elf show a strong maternal-effect nonsense suppression due to readthrough of stop codons and are zygotically lethal during larval stages.

(Chao et al., 2003)

Depletion of the Elf gene product in spermatocytes might lead to the global disruptions in meiotic spindle assembly seen in mutant spermatocytes.

(Basu et al., 1998)

Mutants exhibit male sterility, frequent failure to maintain proper assembled spindles after metaphase.

(Basu et al., 1997)

The gene product may be required to help mediate assembly and maintenance of asters and the central spindle.

(Basu et al., 1997)

Elf is involved in mediating cytokinesis and chromosome segregation in spermatocytes, identified on the basis of hypomorphic mutant phenotypes.

(Basu, 1997.4.19)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Elf CG6382

(Zhong, 1999.11)

Source for identity of: eRF3 Elf

(Marygold et al., 2017)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG6382

(National Institute of Genetics Fly Stocks, 2022-, Marygold et al., 2017, Christis and Munro, 2012, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Quinones-Coello, 2007, Lasko, 2000)

DSUP35

(Brogna et al., 2002)

Dsup35

(Basu, 1997.2.6)

Elf

(Titlow et al., 2023, Dent et al., 2015, Luck et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Ambegaokar and Jackson, 2011, Friedman et al., 2011, Christensen et al., 2008.4.15, Buszczak et al., 2007, Marygold et al., 2007, Quinones-Coello, 2007, Walser et al., 2006)

deRF3

(Wu et al., 2019)

delf

(Basu, 1997.4.19)

dsup35

(Basu et al., 1998)

eRF3

(Karki et al., 2022, Evans et al., 2021, Uçkun et al., 2021, Lu and Guo, 2020, Levis, 2018.8.30, Marygold et al., 2017, Transgenic RNAi Project members, 2017-, Bejsovec et al., 2003, Chao et al., 2003, Inagaki and Ford Doolittle, 2000, Lasko, 2000)

elf

(Lye et al., 2014)

Name Synonyms

Ef1α-like factor

(Basu et al., 1997)

eukaryotic release factor 3

(Chao et al., 2003)

eukaryotic translation release factor 3

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 72 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34658

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VK85

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VK85

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020443

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34658/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020443

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020443

FlyMine - An integrated database for Drosophila genomics

FBgn0020443

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6382

MARRVEL_MODEL - MARRVEL (model organism gene)

34658

Linkouts

BioGRID - A database of protein and genetic interactions.

60705

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020443

DroID - A comprehensive database of gene and protein interactions.

FBgn0020443

DRSC - Results frm RNAi screens

FBgn0020443

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020443

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020443

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6382

Flygut - An atlas of the Drosophila adult midgut

FBgn0020443

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0020443

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006729

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

34658

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (79)

The following external sites may use different assemblies or annotations than FlyBase.

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