Elf, Dsup35, delf
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
619 (aa); 85 (kD observed); 66 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eRF3 using the Feature Mapper tool.
elf protein is primarily detected in the testis in adult males on Western blots though some is also present in the residual carcasses. It is detected by immunolocalization as low level, nonuniform staining throughout the spermatogonia, the spermatocytes, and the spermatids. In mature primary spermatocytes, staining is observed in single discrete spots within the nuclei of most primary spermatocytes. In a few, a pair of intense spots is seen.
GBrowse - Visual display of RNA-Seq signalsView Dmel\eRF3 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutations in Elf show a strong maternal-effect nonsense suppression due to readthrough of stop codons and are zygotically lethal during larval stages.
Depletion of the Elf gene product in spermatocytes might lead to the global disruptions in meiotic spindle assembly seen in mutant spermatocytes.
Mutants exhibit male sterility, frequent failure to maintain proper assembled spindles after metaphase.
The gene product may be required to help mediate assembly and maintenance of asters and the central spindle.