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Gene Dmel\Dad

General Information
Symbol	Dmel\Dad	Species	D. melanogaster
Name	Daughters against dpp	Annotation symbol	CG5201
Feature type	protein_coding_gene	FlyBase ID	FBgn0020493
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	1883
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89E11-89E11	Sequence location	3R:12,879,729..12,896,130 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Daughters against dpp is referred to in FlyBase by the symbol Dmel\Dad (CG5201, FBgn0020493). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity. There is experimental evidence for 14 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; post-embryonic organ morphogenesis; regulation of developmental process; cellular component organization or biogenesis; localization; cellular component movement; instar larval or pupal morphogenesis; instar larval development; digestive tract development. 37 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; thoracic segment; portion of tissue; imaginal precursor; late extended germ band embryo; peripheral nervous system; dorsal branch primordium; organelle; synapse; external compound sense organ. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Dwarfin; MAD homology 1, Dwarfin-type; MAD homology, MH1; SMAD domain, Dwarfin-type; SMAD domain-like; SMAD/FHA domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633556_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Dad. Gene sequence location is 3R:12879729..12896130.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms regulation of phosphorylation protein binding
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89E11-89E11   Limits computationally determined from genome sequence between P{EP}CG5208EP562&P{EP}DadEP3196 and P{PZ}l(3)0788207882
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89E-89E     (Tsuneizumi, 1997.5.21) 89E10-89E11   (determined by in situ hybridisation)   (Spradling et al., 1999) 89E-89F   (determined by in situ hybridisation)   (Tsuneizumi et al., 1997) 89E10-89E11   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dad for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 DGC clone GH23534 appears problematic: incomplete CDS Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dad-RA FBtr0083393  NM_057912   3767   568 Dad-RB FBtr0083394  NM_169740   3550   568 Dad-RC FBtr0100160  NM_001014629   3751   568
Additional Transcript Data & Comments
Reported size (kB)	3.8 (longest cDNA) (Tsuneizumi et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dad-PA   FBpp0082834   63.6   568   7.87     NP_477260   AAN13728 Dad-PB   FBpp0082835   63.6   568   7.87     NP_732196   AAF55383 Dad-PC   FBpp0099512   63.6   568   7.87     NP_001014629   AAX52959
Additional Polypeptide Data & Comments
Reported size (kDa)	568 (aa); 63.6 (kD predicted) (Tsuneizumi et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SMAD domain, Dwarfin-type (IPR001132) MAD homology 1, Dwarfin-type (IPR003619) SMAD/FHA domain (IPR008984) MAD homology, MH1 (IPR013019) Dwarfin (IPR013790) SMAD domain-like (IPR017855)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA433221   AE014297 AAF55383   AE014297 AAN13728   AE014297 AAX52959   AB004232 BAA22841   AC007807   AI292505   AI403970   AQ025305   AQ026297   AQ073944   AX093935   AY070520 AAL47991   BG632881   BI622395   BI631612   BT016082 AAV36967   CO178721   CO187832   CO275149   CO297632   CO310696   CO320059   CO326250   CO328559   CO333829   CZ467668   CZ467669   CZ469534   CZ472691   CZ473865   CZ479346   CZ479780   CZ481794   DN154161   EC064705   EC078605   EC080421   EC080579   EC087567   EC195929   EC203764   EC213037   EC213657   EC238634   EC239583   EC239905   EC246002   EC246679   EC255589   EC260720   ES688523   GH941971   GH942711   GH943112   GH943416   GH944559   GH944725   GH945439   GH945470   GH946467   GH947222   GH948203   GH948423   GH950189   GH950228   GH952223   GH959543   GH960372   GH960550   GH963152   GH965087   GH966954   GH968120   GH969842   GH970406   GH971000   GH972453   GH973669   GH973683   GH973806   GH974872   GH978501   GH978528   GH981790   GH982627
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q5U110 Q8SZT4 O15968
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435541 3R:12,890,673..12,891,685 evidence=Reporter construct (in vivo) (Weiss et al., 2010, Halfon, 2012.6.19) regulatory region FBsf0000436468 3R:12,881,903..12,882,623 evidence=Reporter construct (in vivo) (Junion et al., 2012, Halfon, 2012.6.19) regulatory region FBsf0000436543 3R:12,881,961..12,882,498 evidence=Reporter construct (in vivo) (Weiss et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   dorsal ectoderm   (Marty et al., 2000) third instar larval stage   wing disc | restricted   (Tsuneizumi et al., 1997)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{lacZ}DadP1883 Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Tsuneizumi et al., 1997) third instar larval stage   wing disc | restricted   (Tsuneizumi et al., 1997) oogenesis   female germline stem cell   (Song et al., 2004) cystoblast | subset   (Song et al., 2004) spermatogenesis   male germline stem cell   (Kawase et al., 2004) primary gonial cell   (Kawase et al., 2004)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea    561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop    687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea  (561.1) Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop  (687) Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea    561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop    687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea    561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop    687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea    561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop    687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea  561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop  687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea    561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop    687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    317.925 Larval Midgut    99.3 Larval Hindgut    219.4 Larval Malpighian Tubules    143.9 Larval Fat Body    109 Larval Salivary Gland    27.5 Larval Trachea    561.1 Larval Carcass    281.825 Adult Head    237.5 Adult Eye    422.825 Adult Brain    262.2 Adult Thoracic-Abdominal Ganglion    410 Adult Crop    687 Adult Midgut    279.9 Adult Hindgut    329.5 Adult Malpighian Tubules    268 Adult Fat Body    230.7 Adult Salivary Gland    386.4 Adult Heart    217.525 Adult VirginFemale Spermatheca    333.9 Adult InseminatedFemale Spermatheca    371.5 Adult Ovary    124.9 Adult Testis    33.2 Adult Male Accessory Gland    100.4 Adult Carcass    261.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    237.5   NA  Eye    422.825   NA  Brain    262.2   317.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    410   NA  Crop    687   99.3  Midgut    279.9   219.4  Hindgut    329.5   143.9  Malpighian Tubules    268   109  Fat Body    230.7   27.5  Salivary Gland    386.4   NA  Heart    217.525   561.1  Trachea    NA   NA  VirginFemale Spermatheca    333.9   NA  InseminatedFemale Spermatheca    371.5   NA  Ovary    124.9   NA  Testis    no informative data   NA  Male Accessory Gland    100.4   281.825  Carcass    261.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (37) central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering  (27) carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (37) central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering  27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    20 central nervous system, pupae P8    20 head, virgin 1-day female    19 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    27 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    18 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    3 embryo 04-06hr    6 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    12 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    10 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    6 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    5 embryonic Kc167    10 embryonic S1    13 embryonic S3    4 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    2 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    8 ovary fGS/OSS    4 ovary OSC    10 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020493 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5201-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone, with Scer\GAL4Act5C.PP DadScer\UAS.cTa lethal, with Scer\GAL432B DadScer\UAS.cTa lethal, with Scer\GAL469B DadScer\UAS.cTa lethal, with Scer\GAL4ap-md544 DadScer\UAS.cTa lethal, with Scer\GAL4C-765 DadScer\UAS.cTa lethal, with Scer\GAL4Dll-md23 DadScer\UAS.cTa lethal, with Scer\GAL4dpp.blk1 DadScer\UAS.cTa lethal, with Scer\GAL4en-e16E DadScer\UAS.cTa lethal, with Scer\GAL4how-24B DadScer\UAS.cTa lethal, with Scer\GAL4pnr-MD237 DadGD1335 lethal, with Scer\GAL4ptc-559.1 DadScer\UAS.cTa lethal, with Scer\GAL4T80 DadScer\UAS.cTa lethal | recessive Dadj1E4 DadP1883 partially lethal - majority die DadCB04353 Dadj1E4 Dadsl partially lethal - majority die | recessive Dadj1E4 Other Phenotypes Allele cell shape defective, with Scer\GAL4Ubx-lac1-Gal4 DadScer\UAS.cTa increased cell death | somatic clone, with Scer\GAL4Act5C.PI DadScer\UAS.cTa mitotic cell cycle defective | cell autonomous | somatic clone | third instar larval stage DadScer\UAS.cTa mitotic cell cycle defective | cell non-autonomous | somatic clone | third instar larval stage DadScer\UAS.cTa neuroanatomy defective, with Scer\GAL4Rapgap1-OK6 DadScer\UAS.cTa neuroanatomy defective | larval stage Dadj1E4 neuroanatomy defective | larval stage (with Dad271-68) Dadj1E4 neuroanatomy defective | larval stage (with Dadj1E4) Dad271-68 neuroanatomy defective | recessive Dad271-68 neuroanatomy defective | third instar larval stage Dad271-68 Dadj1E4 neurophysiology defective, with Scer\GAL4Mhc.PW DadScer\UAS.cTa visible, with Scer\GAL4A9 DadScer\UAS.cTa visible, with Scer\GAL4Bx-MS1096 DadScer\UAS.cTa visible, with Scer\GAL4dpp.3KK DadEP-459 DadScer\UAS.cTa visible, with Scer\GAL4dpp.s-hc DadScer\UAS.cTa visible, with Scer\GAL4vg.PM DadScer\UAS.cTa visible | dominant Dadj1E4 Phenotype manifest in Allele amnioserosa, with Scer\GAL4pAS DadScer\UAS.cTa anterior crossvein, with Scer\GAL471B DadScer\UAS.cTa bouton | supernumerary Dad271-68 dorsal appendage Dadj1E4 dorsal appendage, with Scer\GAL4CY2 DadScer\UAS.cTa dorsal appendage | ectopic Dadj1E4 dorsal branch primordium, with Scer\GAL4btl.PS DadScer\UAS.cTa egg operculum, with Scer\GAL4CY2 DadScer\UAS.cTa embryonic anterior Malpighian tubule, with Scer\GAL4byn-Gal4 DadScer\UAS.cTa embryonic dorsal epidermis, with Scer\GAL4pAS DadScer\UAS.cTa eye disc & peripodial epithelium, with Scer\GAL4c311 DadScer\UAS.cTa eye photoreceptor cell stalk, with Scer\GAL4bi-omb-Gal4 DadScer\UAS.cTa fat body, with Scer\GAL4Act5C.PI DadScer\UAS.cTa female germline stem cell Dad271-68 female germline stem cell, with Scer\GAL4nos.PG DadScer\UAS.cTa female germline stem cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.P\T.cJa filamentous actin, with Scer\GAL4pAS DadScer\UAS.cTa germline cell | female | larval stage, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.cTa germline cyst | ectopic, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.cTa histoblast | somatic clone, with Scer\GAL4Scer\FRT.Act5C DadScer\UAS.cTa histoblast nest | somatic clone, with Scer\GAL4Scer\FRT.Act5C DadScer\UAS.cTa lamina, with Scer\GAL4bi-omb-Gal4 DadScer\UAS.cTa lamina anlage glial cell, with Scer\GAL4bi-omb-Gal4 DadScer\UAS.cTa lamina intrinsic neuron, with Scer\GAL4bi-omb-Gal4 DadScer\UAS.cTa lamina tangential neuron, with Scer\GAL4bi-omb-Gal4 DadScer\UAS.cTa male germline stem cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.cTa maxillary palpus, with Scer\GAL4dpp.s-hc DadScer\UAS.cTa mesothoracic extracoxal depressor muscle 66, with Scer\GAL41151 DadScer\UAS.cTa neuromuscular junction Dad271-68 neuromuscular junction, with Scer\GAL4Rapgap1-OK6 DadScer\UAS.cTa NMJ bouton Dad271-68 NMJ bouton | larval stage | supernumerary Dadj1E4 NMJ bouton | larval stage | supernumerary (with Dad271-68) Dadj1E4 NMJ bouton | larval stage | supernumerary (with Dadj1E4) Dad271-68 NMJ bouton | third instar larval stage Dadj1E4 peripodial epithelium, with Scer\GAL4Ubx-lac1-Gal4 DadScer\UAS.cTa spermatocyte, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.cTa spermatogonium, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.cTa testis, with Scer\GAL4nos.UTR.T:Hsim\VP16 DadScer\UAS.cTa thoracic adult muscle precursor cell, with Scer\GAL41151 DadScer\UAS.cTa tracheal tip cell | embryonic stage, with Scer\GAL4btl.PS DadScer\UAS.cTa ventral thoracic disc, with Scer\GAL4Dll-md23 DadScer\UAS.cTa vibrissae, with Scer\GAL4dpp.s-hc DadScer\UAS.cTa wing Dadj1E4 wing, with Scer\GAL4Bx-MS1096 DadScer\UAS.cTa wing, with Scer\GAL4Gug-AGiR DadScer\UAS.cTa wing, with Scer\GAL4nub-AC-62 DadScer\UAS.cTa wing, with Scer\GAL4salm-459.2 DadScer\UAS.cTa wing, with Scer\GAL4vg.PM DadScer\UAS.cTa wing disc, with Scer\GAL4A9 DadScer\UAS.cTa wing disc, with Scer\GAL4Dll-md23 DadScer\UAS.cTa wing disc, with Scer\GAL4Gug-AGiR DadScer\UAS.cTa wing disc, with Scer\GAL4nub-AC-62 DadScer\UAS.cTa wing disc, with Scer\GAL4Ubx-lac1-Gal4 DadScer\UAS.cTa wing disc | cell autonomous | third instar larval stage DadScer\UAS.cTa wing disc | cell non-autonomous | medial | third instar larval stage DadScer\UAS.cTa wing disc | somatic clone, with Scer\GAL4Act5C.PI DadScer\UAS.cTa wing margin, with Scer\GAL4Gug-AGiR DadScer\UAS.cTa wing pouch, with Scer\GAL4en-e16E DadScer\UAS.cTa wing vein Dad271-68 wing vein, with Scer\GAL4dpp.3KK DadScer\UAS.cTa DadEP-459 wing vein, with Scer\GAL4salm-459.2 DadScer\UAS.cTa wing vein | ectopic Dad271-68 Dadj1E4 wing vein L2 Dad212 wing vein L4, with Scer\GAL471B DadScer\UAS.cTa wing vein L5, with Scer\GAL471B DadScer\UAS.cTa
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of Dad Class Mutagen Stocks Known lesion Dadj1E4 P-element activity 2 -- Dad5-HA-1208 1 -- Dad5-HA-2296 1 -- Dad5-SZ-3138 1 -- Dadc02089 piggyBac transposase 1 -- Dadc04820 piggyBac transposase 1 -- Dadd02235 P-element activity 1 -- Dadd04322 P-element activity 1 -- Dade01533 piggyBac transposase 1 -- Dade01972 piggyBac transposase 1 -- Dade04042 piggyBac transposase 1 -- DadEP3196 P-element activity 1 Yes DadEY00775 1 -- DadGS7178 1 Yes DadMI04922 1 -- DadNP0974 1 -- Dad1 0 -- Dad212 P-element activity 0 Yes Dad271-68 P-element activity 0 Yes DadCB04353 P-element activity 0 Yes DadEP-459 0 -- DadEP3361 P-element activity 0 Yes DadHC111A P-element activity 0 Yes DadHC7 P-element activity 0 Yes DadP1883 P-element activity 0 -- Dadp1883Δ32 0 -- DadPZ P-element activity 0 Yes Dadsl 0 -- DadΔ1883-3a 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dad Class Mutagen Stocks Known lesion DadGD1335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DadHMS01102 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DadJF02133 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DadT:Avic\GFP-SF,T:Zzzz\FLAG in vitro construct - coding region fusion 1 Yes DadKK108340 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DadNIG.5201R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DadScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes DadScer\UAS.P\T.cJa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)C4 (Spradling et al., 1999) Df(3R)ED5780 (Ryder and Roote, 2004.11.10)
Disrupted in	Df(3R)Exel6176 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1335} NA P{KK108340} NA P{NIG.5201R} NA P{TRiP.HMS01102} NA P{TRiP.JF02133} NA P{UAS-Dad.T} NA P{UASp-Dad.J} NA reporter construct P{Dad-lacZ.5xAE-1} No P{Dad-lacZ.5xAE} No P{Dad-lacZ.5xHASE} No P{Dad-lacZ.5xNASE} No P{Dad-lacZ.5xSE} No P{Dad-lacZ.5xSE+1} No P{Dad-lacZ.13} No P{Dad-lacZ.13PO} No P{Dad-lacZ.13V} No P{Dad-lacZ.AEd} No P{Dad-lacZ.Int52} No P{Dad-lacZ.m1m4} No P{Dad-lacZ.N} No P{Dad-lacZ.NASE} No P{Dad-lacZ.SBEd} No characterization construct PBac{Dad-GFP.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{HomingPigeon.FRT}DadHC7 No P{HomingPigeon.FRT}DadHC111A No P{lacW}Dadj1E4 No P{lacZ}DadP1883 No P{PZ}DadPZ No insertion of mobile activating element P{EP}DadEP3196 NA P{EP}DadEP3361 NA P{EPgy2}DadEY00775 NA P{GSV1}DadEP-459 NA P{GSV1}EP-435EP-435 NA P{GSV2}DadGS7178 NA P{XP}Dadd02235 NA P{XP}Dadd04322 NA miscellaneous insertions Mi{MIC}DadMI04922 NA P{PTT-GB}DadCB04353 NA P{RS5}Dad5-HA-1208 NA P{RS5}Dad5-HA-2296 NA P{RS5}Dad5-SZ-3138 NA PBac{PB}Dadc02089 NA PBac{PB}Dadc04820 NA PBac{RB}Dade01533 NA PBac{RB}Dade01972 NA PBac{RB}Dade04042 NA insertion of enhancer trap binary system P{GawB}DadNP0974 No
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with sax (Kamiya et al., 2008) inferred from physical interaction with tkv (Kamiya et al., 2008) transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity inferred from genetic interaction with Mad AND inferred from genetic interaction with tkv (Tsuneizumi et al., 1997)
Biological Process
CV term Evidence References
anterior/posterior pattern specification, imaginal disc inferred from mutant phenotype (McClure and Schubiger, 2005) BMP signaling pathway involved in Malpighian tubule cell chemotaxis inferred from direct assay (Bunt et al., 2010) cell elongation involved in imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Widmann and Dahmann, 2009) cell migration inferred from mutant phenotype (Ninov et al., 2010) eye-antennal disc development inferred from mutant phenotype (Stultz et al., 2006) germ-line stem cell maintenance inferred from mutant phenotype (Shivdasani and Ingham, 2003) histoblast morphogenesis inferred from mutant phenotype (Ninov et al., 2010) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) Malpighian tubule morphogenesis inferred from mutant phenotype (Bunt et al., 2010) morphogenesis of larval imaginal disc epithelium inferred from mutant phenotype (McClure and Schubiger, 2005) negative regulation of muscle organ development inferred from mutant phenotype (Jaramillo et al., 2009) negative regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Nahm et al., 2010) negative regulation of transforming growth factor beta receptor signaling pathway inferred from genetic interaction with Mad AND inferred from genetic interaction with tkv AND inferred from mutant phenotype (Tsuneizumi et al., 1997) regulation of phosphorylation inferred from direct assay (Kamiya et al., 2008) retinal ganglion cell axon guidance inferred from mutant phenotype (Yoshida et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR013019 (FlyBase Curators et al., 2004-) transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity traceable author statement (Kawabata and Miyazono, 1999)
Biological Process
CV term Evidence References
negative regulation of transforming growth factor beta receptor signaling pathway traceable author statement (Kawabata and Miyazono, 1999) regulation of transforming growth factor beta receptor signaling pathway inferred from sequence or structural similarity with EMBL:AF010133 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
transcription factor complex inferred from electronic annotation with InterPro:IPR013019 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dad - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - CG13900 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dad - eIF4AIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dad allele Gene References Dad1 os (Bach et al., 2003) Dad271-68 CycE (Horsfield et al., 1998) DadEP3196 pnr (Pena-Rangel et al., 2002) Dadj1E4 H (Johannes and Preiss, 2002) DadP1883 CycE (Horsfield et al., 1998) gbb (Kawase et al., 2004) DadScer\UAS.cTa arm (Ribeiro et al., 2004) Mad (Tsuneizumi et al., 1997) tkv (Tsuneizumi et al., 1997) DadΔ1883-3a CycE (Horsfield et al., 1998) unspecified L (Singh et al., 2005) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67099 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020493 DroID - A comprehensive database of gene and protein interactions. • FBgn0020493 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42059 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q5U110
Orthologs
OrthoDB Orthologs (28) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG651F9B Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6B2RSR Arthropod inclusive ortholog search EOG69CNQ7 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG651F9B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dad     Drosophila simulans   Dsim\GD19135 Y   Drosophila sechellia   Dsec\GM15202 Y   Drosophila erecta   Dere\GG21962 Y   Drosophila yakuba   Dyak\GE24606 Y   Drosophila ananassae   Dana\GF17083 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18732 Y   Drosophila persimilis   Dper\GL21924 Y   Drosophila willistoni   Dwil\GK13383 Y   Drosophila virilis   Dvir\GJ10569 Y   Drosophila mojavensis   Dmoj\GI23854 Y   Drosophila grimshawi   Dgri\GH19558 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6B2RSR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50411   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26955   Atta cephalotes Leafcutter ant  Acep\ACEP26217   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22944   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20495   Linepithema humile Argentine ant  Lhum\LH18667   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27298   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27302   Solenopsis invicta Red fire ant  Sinv\SINV22023   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009993   Acyrthosiphon pisum Pea aphid  Apim\ACYPI064940   Bombyx mori Silkmoth  Bmor\BGIBMGA013476   Pediculus humanus Human body louse  Phum\PHUM411970   Tribolium castaneum Red flour beetle  Tcas\Dad
Orthologs in non-Insect Arthropods (EOG69CNQ7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_35004   Ixodes scapularis Deer tick  Isca\ISCW007410
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19135 Drosophila sechellia Dsec\GM15202 Drosophila erecta Dere\GG21962 Drosophila yakuba Dyak\GE24606 Drosophila ananassae Dana\GF17083 Drosophila pseudoobscura pseudoobscura Dpse\GA18732 Drosophila persimilis Dper\GL21924 Drosophila willistoni Dwil\GK13383 Drosophila virilis Dvir\GJ10569 Drosophila mojavensis Dmoj\GI23854 Drosophila grimshawi Dgri\GH19558
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	42669 w1118; PBac{Dad-GFP.FLAG}VK00037
Harvard	- P{XP}Dadd02235 - P{XP}Dadd04322 - PBac{PB}Dadc02089 - PBac{PB}Dadc04820 - PBac{RB}Dade01533 - PBac{RB}Dade01972 - PBac{RB}Dade04042
Kyoto	125141 w1118; P{RS5}Dad5-HA-1208 125590 w1118; P{RS5}Dad5-HA-2296 125913 w1118; P{RS5}Dad5-SZ-3138
VDRC	v42840 w1118; P{GD1335}v42840
	More stocks available...
Genomic Clones ( 2 )
	BACR01E04 BACR03M20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH23534 LD47465
Other clones	DPiM_LD47465
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH54257 RH61224
Other clones	56808 65379 80247 99605 99671 102616 154634 163557 177212 210988.2 214217.57 214545.42 282455 CK01.31B.F4 CK01.40B.E12 CK01.72C.F5 EK033839 EK057423 EK116603 EK170235 EK192554 EK222314 EK282021 EK290857 EK308119 EP03520 GH15427 RP004146866 RP004174064 RP004175929 RP004199208 RP004199886 RP004211118 RP004219381 RP004219544 RP004227683 RP004230583 RP004230921 RP004238330 RP004239472 RP004252900 RP004253510 RP004256343 RP004257770 RP004259309 RP004260670 RP004354890 RP004375397 RP004377433 RP004377549 RP004397684 RP004419031 RP004427485 RP004434870 RP004459728 RP004473847 RP004496396 RP004517500 RP004544225 RP004545990 RP004557153
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020493 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42059
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dad anon-EST:fe1F5 (FlyBase, 1996-) Source for merge of: Dad EP3196 (Bidet et al., 2003) Source for merge of: Dad l(3)j1E4 (Henderson et al., 1999)
Additional comments	Dad can antagonize BMP signalling in Xenopus embryos. (Tsuneizumi et al., 1997)
Other Comments
	Area matching Drosophila DAD gene, Acc. No. AB004232. (Davies, 2001.3.15) Dad may be capable of antagonizing signals from both the Dpp/BMP and TGF-beta/Activin TGF-beta subfamilies. (Marquez et al., 2001) Overexpression of Dad, Hsap\MADH6 or Hsap\MADH7 have comparable, truncated leg phenotypes. (Marquez et al., 2001) Dad mutations have no effect on salivary gland formation. (Henderson et al., 1999) Loss of function alleles of Dad, enhance the CycEJP mutant eye phenotype. (Horsfield et al., 1998) Transcription of Dad is induced by the dpp signal. The Dad product shows weak homology to Mad. (Tsuneizumi and Tabata, 1997) The pattern organizing mechanism governed by dpp may involve a negative feedback circuit mediated by Dad. (Tsuneizumi and Tabata, 1997) The transcription of Dad is induced by dpp, while the action of Dad antagonizes dpp. (Tsuneizumi et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057912 NM_169740 NM_001014629 RefSeq (Proteins) • NP_477260 NP_732196 NP_001014629 DDBJ / EMBL / GenBank • AA433221 AAF55383 AAF55383.1 AAL47991 AAN13728 AAN13728.1 AAV36967 AAX52959 AB004232 AC007807 AI403970 AQ025305 AQ026297 AQ073944 AX093935 AY070520 BAA22841 BT016082 CZ467668 CZ467669 CZ469534 CZ472691 CZ473865 CZ479346 CZ479780 CZ481794 Entrez Gene - A searchable database of RefSeq genes. • 42059 UniProtKB/TrEMBL • O15968 Q5U110 Q8SZT4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SMAD domain, Dwarfin-type (IPR001132) MAD homology 1, Dwarfin-type (IPR003619) SMAD/FHA domain (IPR008984) MAD homology, MH1 (IPR013019) Dwarfin (IPR013790) SMAD domain-like (IPR017855)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67099 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0020493 DroID - A comprehensive database of gene and protein interactions. • FBgn0020493 DRSC - Results from RNAi screens. • FBgn0020493 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020493 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5201-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020493 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42059 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/dad1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42059 modMine - Data generated by the modENCODE project. • FBgn0020493 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q5U110
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	1883 (Tsuneizumi et al., 1997, Tsuneizumi and Tabata, 1997, ) anon-EST:fe1F5   CG5201 (Mohit et al., 2006, Quinones-Coello, 2007, Molnar et al., 2006, Perkins et al., 2009.3.31, Ni et al., 2010.12.1, Keleman et al., 2009.8.5) Dad (Jordan et al., 2005, Ward et al., 2006, Rogulja and Irvine, 2005, Xi and Xie, 2005, Tyler et al., 2007, Yavari et al., 2007, Dudu, 2006, Martin-Castellanos and Edgar, 2002, Stultz et al., 2006, Kruger, 2005, Dudu et al., 2006, Gregory et al., 2007, Dworkin and Gibson, 2006, Bunt and Hime, 2004, Chen and Schupbach, 2006, Kirilly et al., 2005, Buszczak et al., 2007, Quinones-Coello, 2007, de Navascués and Modolell, 2007, Song et al., 2007, Crickmore and Mann, 2007, Payne and Braun, 2006, Molnar et al., 2006, Wada et al., 2007, Kirilly et al., 2011, Ables and Drummond-Barbosa, 2010, Sato et al., 2010, Galindo et al., 2011, Umemori et al., 2009, Yakoby et al., 2008, Choksi et al., 2006, Grammont, 2007, Wang et al., 2008, Kucherenko et al., 2008, Chang et al., 2008, Yakoby et al., 2008, Ng, 2008, Goold and Davis, 2007, Franciscovich et al., 2008, Ogiso et al., 2011, Zartman et al., 2008, Ziv et al., 2009, Narbonne-Reveau et al., 2006, Jaramillo et al., 2009, Shen et al., 2008, Zahedi et al., 2008, Widmann and Dahmann, 2009, Kamiya et al., 2008, Zeng et al., 2007, Pinto et al., 2008, Zeitlinger et al., 2007, Guo and Wang, 2009, Zhao et al., 2008, Firth et al., 2010, Ballard et al., 2010, Li et al., 2010, Jin et al., 2008, Kagey et al., 2012, Leatherman and Dinardo, 2010, Chen et al., 2010, König et al., 2011, Dworkin et al., 2011, Liu et al., 2011, Wang et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Lu et al., 2012, Spokony and White, 2012.11.14) dad (Dworkin and Gibson., 2006, Gilboa and Lehmann, 2004, Shivdasani and Ingham, 2003, Marty et al., 2000, Sweeney and Davis, 2002, Sanyal and Ramaswami, 2002, Adachi-Yamada and O'Connor, 2002, Nakagoshi et al., 2002, Cavodeassi et al., 2002, Ribeiro et al., 2002, Kubota et al., 2000, Podos and Ferguson, 1999, Kudoh, 1999, Kudoh, 1999, Horsfield et al., 1998, Whitman, 1998, Cho and Blitz, 1998, Henderson and Andrew, 1998, Weiss et al., 2006, Mohit et al., 2006, Sotillos and De Celis, 2005, Eaton and Davis, 2005, Weiss et al., 2007, Kaneko et al., 2011, Hadar et al., 2012, Szuperák et al., 2011, Chang et al., 2008, Chau et al., 2008, Narbonne-Reveau et al., 2006, Molnar et al., 2006, Shen et al., 2008, Kyoda et al., 2000, Shravage et al., 2007, Ogiso et al., 2011, Wartlick et al., 2011, Nahm et al., 2010, Umemori et al., 2009, Oh and Irvine, 2011, Jiang et al., 2008, Xu et al., 2007, Barrio et al., 2007, O'Keefe et al., 2007, Umemori et al., 2007, Tanaka et al., 2007, O'Connor-Giles et al., 2008, Liu et al., 2009, McKay et al., 2009, Lindner et al., 2007, Foronda et al., 2009, Cruz et al., 2009, Hayashi et al., 2009, Ninov et al., 2010, Ballard et al., 2010, Franciscovich et al., 2008, Vuilleumier et al., 2010, Leatherman and Dinardo, 2010, Bunt et al., 2010, Goldstein et al., 2011, Weiss et al., 2010, Rodal et al., 2011, Pennetier et al., 2012, Xia et al., 2010) DAD (Tsuneizumi, 1997.5.21, Lembong et al., 2009) Dad1 (Xie and Spradling, 1998) EP3196   EP(3)3196 (Pena-Rangel et al., 2002) l(3)j1E4 (Johannes and Preiss, 2002, )
Name Synonym	anon-fast-evolving-1F5   daughter against dpp (Jiang et al., 2008) Daughters against dpp (Jordan et al., 2005, Li and White, 2003, Gregory et al., 2007, Dworkin and Gibson, 2006, Chang et al., 2008, Guo and Wang, 2009) daughters against dpp (Tsuneizumi, 1997.5.21, Ogiso et al., 2011, Oh and Irvine, 2011, Umemori et al., 2007, Lindner et al., 2007, Foronda et al., 2009, Zhao et al., 2008, Vuilleumier et al., 2010) Daughters against Dpp (Umemori et al., 2009, Tanaka et al., 2007, Pinto et al., 2008) Daughters against DPP (Lembong et al., 2009)
Secondary FlyBase IDs
	FBgn0024521 FBgn0025250 FBgn0062662
References ( 236 )
Generate a list of	All references relating to this gene ( 236 )
List References by type	Research paper  ( 151 ) Supplementary material  ( 7 ) Review  ( 32 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 18 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 2 ) Conference report  ( 1 )
Recent research papers ( 25 )
	Peterson and O'Connor, 2013, Development 140(3): 649--659 Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements. [FBrf0220378] Acharya et al., 2012, G3 (Bethesda) 2(11): 1459--1472 Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein. [FBrf0220009] Bischoff, 2012, Dev. Biol. 363(1): 179--190 Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila. [FBrf0217475] Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Junion et al., 2012, Cell 148(3): 473--486 A transcription factor collective defines cardiac cell fate and reflects lineage history. [FBrf0217404] Kagey et al., 2012, Mech. Dev. 129(9-12): 339--349 Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. [FBrf0219794] Lu et al., 2012, PLoS Biol. 10(7): e1001357 Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells. [FBrf0218889] Pennetier et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(9): 3389--3394 Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals. [FBrf0217568] Ziv et al., 2012, J. Cell Sci. 125(23): 5811--5818 Inverse regulation of target genes at the brink of the BMP morphogen activity gradient. [FBrf0220860] Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Eliazer et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(17): 7064--7069 Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary. [FBrf0213593] Galindo et al., 2011, Dev. Biol. 353(2): 396--410 Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers. [FBrf0213529] Goldstein et al., 2011, Hum. Mol. Genet. 20(5): 894--904 SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy. [FBrf0212934] Hamaratoglu et al., 2011, PLoS Biol. 9(10): e1001182 Dpp signaling activity requires pentagone to scale with tissue size in the growing Drosophila wing imaginal disc. [FBrf0216502] Kaneko et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(27): 11127--11132 Smad inhibition by the Ste20 kinase Misshapen. [FBrf0214278] Kirilly et al., 2011, Development 138(23): 5087--5097 Self-maintained escort cells form a germline stem cell differentiation niche. [FBrf0216598] König et al., 2011, EMBO J. 30(8): 1549--1562 Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. [FBrf0213531] Liu et al., 2011, Dev. Growth Differ. 53(6): 822--841 Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila. [FBrf0214664] Ogiso et al., 2011, Dev. Growth Differ. 53(5): 668--678 Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad. [FBrf0213936] Oh and Irvine, 2011, Dev. Cell 20(1): 109--122 Cooperative Regulation of Growth by Yorkie and Mad through bantam. [FBrf0212763] Rodal et al., 2011, J. Cell Biol. 193(1): 201--217 A presynaptic endosomal trafficking pathway controls synaptic growth signaling. [FBrf0213353] Szuperák et al., 2011, Development 138(4): 715--724 Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida. [FBrf0212881] Wang et al., 2011, PLoS Genet. 7(12): e1002426 Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. [FBrf0217048] Wartlick et al., 2011, Science 331(6021): 1154--1159 Dynamics of Dpp signaling and proliferation control. [FBrf0214313] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...