FlyBase Gene Report: Dmel\emb

General Information

Symbol

Dmel\emb

Species

D. melanogaster

Name

embargoed

Annotation Symbol

CG13387

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020497

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Snapshot

embargoed (emb) encodes an exportin involved in protein export from the nucleus. It regulates the response to hypoxia and is involved in centriole replication. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Crm1, dCRM1, Exportin, l(2)k16715, Chromosomal region maintenance 1

Key Links

Genomic Location

Cytogenetic map

29C1-29C3

Sequence location

2L:8,403,573..8,408,853 [+]

Recombination map

2-32

RefSeq locus

NT_033779 REGION:8403573..8408853

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

nuclear export signal receptor activity

inferred from mutant phenotype

(assigned by UniProt )

(Xylourgidis et al., 2006)

inferred from direct assay

(assigned by UniProt )

(Roth et al., 2003)

protein binding

inferred from physical interaction with FLYBASE:Nup214; FB:FBgn0010660

(Xylourgidis et al., 2006)

inferred from physical interaction with UniProtKB:Q9GYU8

(assigned by UniProt )

(Roth et al., 2003)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

nuclear export signal receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000131749

(assigned by GO_Central )

(Gaudet et al., 2011)

Ran GTPase binding

inferred from electronic annotation with InterPro:IPR001494

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

centriole replication

inferred from mutant phenotype

(Dobbelaere et al., 2008)

multicellular organism development

inferred from direct assay

(assigned by UniProt )

(Collier et al., 2000)

nuclear export

inferred from direct assay

(Song et al., 2005)

nuclear pore complex assembly

inferred from mutant phenotype

(assigned by UniProt )

(Hampoelz et al., 2019)

protein export from nucleus

inferred from mutant phenotype

(Irisarri et al., 2009, Bi et al., 2005)

protein transport

inferred from direct assay

(assigned by UniProt )

(Roth et al., 2003)

regulation of cellular response to hypoxia

inferred from mutant phenotype

(Irisarri et al., 2009)

ribosomal small subunit export from nucleus

inferred from mutant phenotype

(Kim et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

regulation of protein export from nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000131749

(assigned by GO_Central )

(Gaudet et al., 2011)

ribosomal large subunit export from nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000131787

(assigned by GO_Central )

(Gaudet et al., 2011)

ribosomal small subunit export from nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000131787

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

nuclear membrane

inferred from direct assay

(Dobbelaere et al., 2008)

nuclear pore

inferred from mutant phenotype

(assigned by UniProt )

(Roth et al., 2003)

nucleus

inferred from direct assay

(Dobbelaere et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000131749

(assigned by GO_Central )

(Gaudet et al., 2011)

nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000131749

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

BETA IMPORTINS

Protein Family (UniProt)

Belongs to the exportin family. (Q9TVM2)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

BETA IMPORTINS -: Importin-β family proteins are nucleocytoplasmic transport receptors that import and export proteins and RNAs through the nuclear pores. In some import/export pathways, importin-β directly interacts with the cargo. For cargo containing a classical nuclear localization (cNLS) signal, importin-α acts as an adaptor linking the cargo to importin-β. (Adapted from FBrf0235243, FBrf0131350 and PMID:21029754).

Protein Function (UniProtKB)

Receptor for the leucine-rich nuclear export signal (NES) (PubMed:10636888, PubMed:14638854, PubMed:16103875). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form (PubMed:10636888, PubMed:14638854). Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm (PubMed:14638854, PubMed:25858587, PubMed:17032737). Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae (PubMed:31626769). Required for the function or maintenance of certain tissues such as brain and gut (PubMed:10924475).

(UniProt, Q9TVM2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\emb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.45

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

emb-RA

FBtr0079663

NM_164818

4492

1063

emb-RB

FBtr0346708

NM_001316387

3919

1063

Additional Transcript Data and Comments

Reported size (kB)

4.2, 3.5 (northern blot)

(Collier et al., 2000)

3.8 (northern blot)

(Fasken et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

emb-PA

FBpp0079278

122.8

1063

5.70

NP_723391

AAG22423

emb-PB

FBpp0312321

122.8

1063

5.70

NP_001303316

ALI30202

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1063 aa isoforms: emb-PA, emb-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

1063 (aa)

(Collier et al., 2000)

1063 (aa); 123 (kD predicted)

(Fasken et al., 2000)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Clbn (via its N-terminus) (PubMed:16103875). Associates with the nuclear pore complex via interaction with mbo and Nup214 (PubMed:14638854, PubMed:17032737). Interacts with target proteins containing NES sequences such as actin and dl (PubMed:10924475, PubMed:14638854, PubMed:17032737).

(UniProt, Q9TVM2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\emb using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval midgut

(Collier et al., 2000)

embryonic/larval posterior spiracle

(Collier et al., 2000)

embryonic brain

(Collier et al., 2000)

organism | ubiquitous

(Collier et al., 2000)

embryonic/larval somatic muscle

(Collier et al., 2000)

ventral nerve cord

(Collier et al., 2000)

embryonic/larval hindgut

(Collier et al., 2000)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 15

embryonic brain

(Collier et al., 2000)

embryonic hindgut

(Collier et al., 2000)

posterior spiracle primordium

(Collier et al., 2000)

embryonic stage 15

ventral nerve cord

(Collier et al., 2000)

embryonic/larval midgut primordium

(Collier et al., 2000)

embryonic somatic muscle

(Collier et al., 2000)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

Additional Descriptive Data

emb transcripts are expressed ubiquitously at all stages of embryonic development. Elevated levels are observed in brain, hindgut, and posterior spiracles shortly before dorsal closure and in ventral nerve cord, midgut, and somatic musculature after dorsal closure.

(Collier et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

nuclear membrane

inferred from direct assay

(Dobbelaere et al., 2008)

nuclear pore

inferred from mutant phenotype

(assigned by UniProt )

(Roth et al., 2003)

nucleus

inferred from direct assay

(Dobbelaere et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\emb in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\emb

View exonic expression by tissue for Dmel\emb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020497

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020497

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG13387-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13387

Flygut - An atlas of the Drosophila adult midgut

FBgn0020497

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\emb

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of emb

Transgenic constructs containing regulatory region of emb

Deletions and Duplications ( 5 )

Disrupted in

Df(2L)Exel8021

(Ryder, 2004.4.26)

Df(2L)N22-14

(Collier et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

T(Y;2)fy⁴

(Collier et al., 2000)

Not disrupted in

Df(2L)N22-5

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)TE29Aa-11

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)N22-14)

lethal | recessive

lethal - all die before end of larval stage (with Df(2L)N22-14)

lethal - all die before end of second instar larval stage

emb²

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

emb^GD1239

partially lethal - majority die, with Scer\GAL4^pnr-MD237

emb^GD1239

viable, with Scer\GAL4^tin.CΔ4

emb^GD1239

Other Phenotypes

Allele

some die during larval stage (with Df(2L)N22-14)

some die during pupal stage, with Scer\GAL4^pnr-MD237

emb^GD1239

some die during second instar larval stage

emb²

stress response defective | embryonic stage

emb³

stress response defective | embryonic stage, with Scer\GAL4^en-e16E

emb^UAS.cIa

Phenotype manifest in

Allele

annulate lamellae | oogenesis, with Scer\GAL4^VP16.nos.UTR

emb^HMS00991

embryonic/larval tracheal system

emb^unspecified

oocyte, with Scer\GAL4^VP16.nos.UTR

emb^HMS00991

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\XPO1

13 of 15

Yes

Hsap\XPO5

2 of 15

Hsap\XPO6

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Xpo1

13 of 15

Yes

Mmus\Xpo5

2 of 15

Mmus\Xpo6

1 of 15

Rattus norvegicus (Norway rat) (3)

Rnor\Xpo1

13 of 13

Yes

Rnor\Xpo5

2 of 13

Rnor\Xpo6

1 of 13

Xenopus tropicalis (Western clawed frog) (6)

Xtro\xpo1

9 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (4)

Drer\xpo1b

13 of 15

Yes

Drer\xpo1a

11 of 15

Yes

Drer\xpo5

2 of 15

Drer\xpo6

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\xpo-1

12 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\XPO1A

9 of 9

Yes

Atha\XPO1B

8 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CRM1

13 of 15

Yes

Scer\MSN5

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\crm1

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901CT )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12246

Drosophila persimilis

Dper\GL25946

Drosophila willistoni

Dwil\GK18416

Drosophila virilis

Dvir\GJ18235

Drosophila mojavensis

Dmoj\GI13968

Drosophila grimshawi

Dgri\GH13431

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500T9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17009084

Glossina morsitans

Tsetse fly

Gmor\GMOY008254

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04319

Mayetiola destructor

Hessian fly

Mdes\Mdes009645

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001484

Anopheles darlingi

American malaria mosquito

Adar\ADAC009480

Anopheles gambiae

Malaria mosquito

Agam\AGAP009929

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009366

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00MS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010657

Danaus plexippus

Monarch butterfly

Dple\DPOGS208474-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004304

Apis florea

Little honeybee

Aflo\2147610723

Apis mellifera

Western honey bee

Amel\emb

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13552

Bombus terrestris

Buff-tailed bumblebee

Bter\15212076

Linepithema humile

Argentine ant

Lhum\LH19165

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001b79

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003078

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05513

Tribolium castaneum

Red flour beetle

Tcas\TC012162

Pediculus humanus

Human body louse

Phum\PHUM345850

Cimex lectularius

Bed bug

Clec\CLEC006386

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006557

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07239

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00LI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR015297

Ixodes scapularis

Black-legged tick

Isca\ISCW004041

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62271.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g00740

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_66185

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_3736

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_327633

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_253003

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307675

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_270167

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G013G )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Xpo1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Xpo1h

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024562

Gallus gallus

Domestic chicken

Ggal\XPO1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

4 of 10

ebo

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

emb^JF01311

exacerbates amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

exacerbates frontotemporal dementia

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Sowa et al., 2018)

emb^NIG.13387R

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chan et al., 2011)

emb^E128-1A

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chan et al., 2011)

emb^EY08770

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Sowa et al., 2018)

emb^E2-1A

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

XPO1; exportin 1

13 of 15

602559

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

emb - CG2064

experimental knowledge based

(Guruharsha et al., 2011)

emb - Cand1

experimental knowledge based

(Guruharsha et al., 2011)

emb - Karyβ3

experimental knowledge based

(Guruharsha et al., 2011)

emb - MRP

experimental knowledge based

(Guruharsha et al., 2011)

emb - Nup214

pull down, anti tag western blot, two hybrid, anti bait coimmunoprecipitation, western blot

(Xylourgidis et al., 2006)

emb - Pp2A-29B

experimental knowledge based

(Guruharsha et al., 2011)

emb - Ranbp9

experimental knowledge based

(Guruharsha et al., 2011)

emb - Scamp

experimental knowledge based

(Guruharsha et al., 2011)

emb - Sec61α

experimental knowledge based

(Guruharsha et al., 2011)

emb - Z600

anti bait coimmunoprecipitation, peptide massfingerprinting

(Gawlinski et al., 2007)

RNA-protein

Physical Interaction

Assay

References

emb - polo

pull down, Identification by mass spectrometry

(Oliveira et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

emb

suppressible

mbo

(Roth et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hid

enhanceable

emb

(Bilen and Bonini, 2007)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9TVM2 )

Linkouts

BioGRID - A database of protein and genetic interactions.

60290

DroID - A comprehensive database of gene and protein interactions.

FBgn0020497

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34167

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-32

Cytogenetic map

29C1-29C3

Sequence location

2L:8,403,573..8,408,853 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

29C1-29C3

Limits computationally determined from genome sequence between P{lacW}l(2)k12914^k12914&P{lacW}Akap200^k07118a and P{lacW}l(2)k03706^k03706&P{lacW}Acer^k07704

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

29C-29C

(Hovemann, 1999.8.27)

29C1-29C5

(Fasken, 1999.9.28)

29C1-29C2

(Collier, 1999.8.23)

29C3-29C4

(determined by in situ hybridisation)

(Spradling et al., 1999)

29C3-29C4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-32

(FlyBase, 2016)

2-27.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

31353

y¹ v¹; P{TRiP.JF01311}attP2

81489

y¹ v¹; P{TKO.GS04819}attP40

11195

y¹ w^67c23; P{lacW}emb^k16715/CyO

19935

y¹ w^67c23; P{EPgy2}emb^EY08770/CyO

34021

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00991}attP2

Kyoto

125029

w¹¹¹⁸; P{RS5}emb^5-HA-1048

102459

y¹ w^67c23 ; P{lacW}emb^k06303 / CyO

114576

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{EPgy2}emb^EY08770 P{neoFRT}40A/CyO y⁺

111361

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}emb^k16715 P{neoFRT}40A/CyO y⁺

VDRC

v103767

P{KK102552}VIE-260B

v3347

w¹¹¹⁸; P{GD1239}v3347

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (117)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD45706

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020497

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020497

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34167

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: emb l(2)k16715

(Collier et al., 2000)

Additional comments

Other Comments

sima protein nuclear export is affected in emb mutant embryos.

(Irisarri et al., 2009)

emb is involved in centriole duplication.

(Dobbelaere et al., 2008)

Mutations of the S.pombe crm1 are suppressed by expression of the Drosophila emb.

(Collier et al., 1997)

Origin and Etymology

Discoverer

Etymology

The gene is named "embargoed" to reflect the nuclear export defects of the mutants.

(Collier et al., 2000)

Identification

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34167

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9TVM2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020497

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020497

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13387

Flygut - An atlas of the Drosophila adult midgut

FBgn0020497

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34167

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG13387

modMine - A data warehouse for the modENCODE project

FBgn0020497

Linkouts

BioGRID - A database of protein and genetic interactions.

60290

DPiM - Drosophila Protein interaction map

FBgn0020497

DroID - A comprehensive database of gene and protein interactions.

FBgn0020497

DRSC - Results frm RNAi screens

FBgn0020497

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020497

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG13387-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020497

FlyMine - An integrated database for Drosophila genomics

FBgn0020497

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34167

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG13387

(Hosono et al., 2015, Ding et al., 2014, Schertel et al., 2013, Christis and Munro, 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Mason and Goldfarb, 2009, Dobbelaere et al., 2008, Ni et al., 2008, Lippai et al., 2000)

CRM1

(Irisarri et al., 2009, Sabri et al., 2007, Xylourgidis et al., 2006, Tootle and Rebay, 2005, Herold et al., 2003, Roth et al., 2003, Roth et al., 2003, Roth et al., 2003, Xylourgidis et al., 2003, Bienz, 2002, Fasken, 1999.9.28)

Crm1

(Kneuss et al., 2019, Freibaum et al., 2015, Kim et al., 2015, Büssing et al., 2010, Gawlinski et al., 2007, Song et al., 2005, Bono et al., 2004, Hieronymus and Silver, 2004, Hovemann, 1999.8.27, Collier and Gubb, 1997, Collier et al., 1997)

DCRM1

(Roth et al., 2003)

Emb

(Oliveira et al., 2019, Sowa et al., 2018, Boeynaems et al., 2016, Schwartz et al., 2016, Finan et al., 2011, Büssing et al., 2010)

XPO-1

(Büssing et al., 2010)

XPO1

(Swevers et al., 2018, Büssing et al., 2010)

Xpo1

(Chan et al., 2011)

crm1

(Nawathean and Rosbash, 2004, Tootle et al., 2003)

dCRM1

(Jin et al., 2012, Roth et al., 2003, Xylourgidis et al., 2003, Fasken et al., 2000)

dXPO1

(Yasunaga et al., 2014)

emb

(Okazaki et al., 2020, Meltzer et al., 2019, Mu et al., 2019, Steyaert et al., 2018, Transgenic RNAi Project members, 2017-, Lee et al., 2016, Schertel et al., 2013, Irisarri et al., 2009, Dobbelaere et al., 2008, McElroy et al., 2008, Bilen and Bonini, 2007, Bi et al., 2005)

l(2)k16715

(Spradling et al., 1999)

Name Synonyms

Chromosomal region maintenance 1

(Collier et al., 1997)

Embargoed

(Deivasigamani et al., 2014, Büssing et al., 2010)

Exportin

(Bi et al., 2005, Bi et al., 2004)

Exportin-1

(Nie et al., 2009)

embargoed

(Hampoelz et al., 2019, Akan et al., 2016, Kimura and Imamoto, 2014, Yasunaga et al., 2014, Irisarri et al., 2009, Mason and Goldfarb, 2009, Bilen and Bonini, 2007, Bi et al., 2005, Roth et al., 2003)

exportin

(Jin et al., 2012)

exportin-1

(Chan et al., 2011)

Secondary FlyBase IDs

FBgn0021807

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (98)

The following external sites may use different assemblies or annotations than FlyBase.

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