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FB2021_04, released August 17, 2021

Gene: Dmel\emb

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General Information
Symbol
Dmel\emb
Species
D. melanogaster
Name
embargoed
Annotation Symbol
CG13387
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020497
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
embargoed (emb) encodes an exportin involved in protein export from the nucleus. It regulates the response to hypoxia and is involved in centriole replication. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Crm1, dCRM1, Exportin, XPO1, l(2)k16715

Key Links
Genomic Location
Cytogenetic map
29C1-29C3
Sequence location
2L:8,403,573..8,408,853 [+]
Recombination map
2-32
RefSeq locus
NT_033779 REGION:8403573..8408853
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables nuclear export signal receptor activity
inferred from direct assay
(assigned by UniProt )
(Roth et al., 2003)
inferred from mutant phenotype
(assigned by UniProt )
(Xylourgidis et al., 2006)
enables protein binding
inferred from physical interaction with UniProtKB:Q9GYU8
(assigned by UniProt )
(Roth et al., 2003)
inferred from physical interaction with FLYBASE:Nup214; FB:FBgn0010660
(Xylourgidis et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables nuclear export signal receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000131749
(assigned by GO_Central )
(Gaudet et al., 2011)
enables small GTPase binding
inferred from electronic annotation with InterPro:IPR001494
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in centriole replication
inferred from mutant phenotype
(Dobbelaere et al., 2008)
involved_in nuclear export
inferred from direct assay
(Song et al., 2005)
involved_in nuclear pore complex assembly
inferred from mutant phenotype
(assigned by UniProt )
(Hampoelz et al., 2019)
involved_in protein export from nucleus
inferred from mutant phenotype
(Irisarri et al., 2009, Bi et al., 2005)
inferred from mutant phenotype
(assigned by UniProt )
(Collier et al., 2000)
involved_in protein transport
inferred from direct assay
(assigned by UniProt )
(Roth et al., 2003)
involved_in ribosomal small subunit export from nucleus
inferred from mutant phenotype
(Kim et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in ribosomal large subunit export from nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000131787
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in ribosomal small subunit export from nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000131787
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nuclear membrane
inferred from direct assay
(Dobbelaere et al., 2008)
part_of nuclear pore
inferred from mutant phenotype
(assigned by UniProt )
(Roth et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000131749
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000131749
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the exportin family. (Q9TVM2)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
embargoed (emb) encodes an exportin involved in protein export from the nucleus. It regulates the response to hypoxia and is involved in centriole replication. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
BETA IMPORTINS -
Importin-β family proteins are nucleocytoplasmic transport receptors that import and export proteins and RNAs through the nuclear pores. In some import/export pathways, importin-β directly interacts with the cargo. For cargo containing a classical nuclear localization (cNLS) signal, importin-α acts as an adaptor linking the cargo to importin-β. (Adapted from FBrf0235243, FBrf0131350 and PMID:21029754).
Protein Function (UniProtKB)
Receptor for the leucine-rich nuclear export signal (NES) (PubMed:10636888, PubMed:14638854, PubMed:16103875). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form (PubMed:10636888, PubMed:14638854). Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm (PubMed:14638854, PubMed:25858587, PubMed:17032737). Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae (PubMed:31626769). Required for the function or maintenance of certain tissues such as brain and gut (PubMed:10924475).
(UniProt, Q9TVM2)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\emb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.45

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
emb-RA
FBtr0079663
NM_164818
4492
1063
emb-RB
FBtr0346708
NM_001316387
3919
1063
Additional Transcript Data and Comments
Reported size (kB)

4.2, 3.5 (northern blot)

(Collier et al., 2000)

3.8 (northern blot)

(Fasken et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
emb-PA
FBpp0079278
122.8
1063
5.70
NP_723391
AAG22423
emb-PB
FBpp0312321
122.8
1063
5.70
NP_001303316
ALI30202
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1063 aa isoforms: emb-PA, emb-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

1063 (aa)

(Collier et al., 2000)

1063 (aa); 123 (kD predicted)

(Fasken et al., 2000)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Clbn (via its N-terminus) (PubMed:16103875). Associates with the nuclear pore complex via interaction with mbo and Nup214 (PubMed:14638854, PubMed:17032737). Interacts with target proteins containing NES sequences such as actin and dl (PubMed:10924475, PubMed:14638854, PubMed:17032737).

(UniProt, Q9TVM2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\emb using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval midgut
(Collier et al., 2000)
embryonic/larval posterior spiracle
(Collier et al., 2000)
embryonic brain
(Collier et al., 2000)
organism | ubiquitous
(Collier et al., 2000)
embryonic/larval somatic muscle
(Collier et al., 2000)
larval ventral nerve cord
(Collier et al., 2000)
embryonic/larval hindgut
(Collier et al., 2000)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 15
embryonic brain
(Collier et al., 2000)
embryonic hindgut
(Collier et al., 2000)
posterior spiracle primordium
(Collier et al., 2000)
embryonic stage 15
larval ventral nerve cord
(Collier et al., 2000)
embryonic/larval midgut primordium
(Collier et al., 2000)
embryonic somatic muscle
(Collier et al., 2000)
Additional Descriptive Data

emb transcripts are expressed ubiquitously at all stages of embryonic development. Elevated levels are observed in brain, hindgut, and posterior spiracles shortly before dorsal closure and in ventral nerve cord, midgut, and somatic musculature after dorsal closure.

(Collier et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nuclear membrane
inferred from direct assay
(Dobbelaere et al., 2008)
part_of nuclear pore
inferred from mutant phenotype
(assigned by UniProt )
(Roth et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\emb in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of emb
Transgenic constructs containing regulatory region of emb
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\XPO1
13 of 15
Yes
Yes
Hsap\XPO5
2 of 15
No
No
Hsap\XPO6
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Xpo1
13 of 15
Yes
Yes
Mmus\Xpo5
2 of 15
No
No
Mmus\Xpo6
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Xpo1
13 of 13
Yes
Yes
Rnor\Xpo5
2 of 13
No
No
Rnor\Xpo6
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\xpo1
9 of 12
Yes
Yes
Xtro\xpo5
2 of 12
No
No
Xtro\exd3
1 of 12
No
No
Xtro\LOC100486598
1 of 12
No
No
Xtro\xpo5.2
1 of 12
No
No
Xtro\xpo6
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\xpo1b
13 of 15
Yes
Yes
Drer\xpo1a
11 of 15
No
Yes
Drer\xpo5
2 of 15
No
No
Drer\xpo6
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\xpo-1
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\XPO1A
9 of 9
Yes
Yes
Atha\XPO1B
8 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CRM1
13 of 15
Yes
Yes
Scer\MSN5
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\crm1
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901CT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000356
Drosophila simulans
Dsim\GD23540
Drosophila sechellia
Dsec\GM16937
Drosophila erecta
Dere\GG10550
Drosophila yakuba
Dyak\emb
Drosophila ananassae
Dana\GF15231
Drosophila pseudoobscura pseudoobscura
Dpse\GA12246
Drosophila persimilis
Dper\GL25946
Drosophila willistoni
Dwil\GK18416
Drosophila virilis
Dvir\GJ18235
Drosophila mojavensis
Dmoj\GI13968
Drosophila grimshawi
Dgri\GH13431
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500T9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009084
Glossina morsitans
Tsetse fly
Gmor\GMOY008254
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04319
Mayetiola destructor
Hessian fly
Mdes\Mdes009645
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001484
Anopheles darlingi
American malaria mosquito
Adar\ADAC009480
Anopheles gambiae
Malaria mosquito
Agam\AGAP009929
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009366
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00MS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010657
Danaus plexippus
Monarch butterfly
Dple\DPOGS208474-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004304
Apis florea
Little honeybee
Aflo\2147610723
Apis mellifera
Western honey bee
Amel\emb
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13552
Bombus terrestris
Buff-tailed bumblebee
Bter\15212076
Linepithema humile
Argentine ant
Lhum\LH19165
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b79
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003078
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05513
Tribolium castaneum
Red flour beetle
Tcas\TC012162
Pediculus humanus
Human body louse
Phum\PHUM345850
Cimex lectularius
Bed bug
Clec\CLEC006386
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006557
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07239
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00LI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015297
Ixodes scapularis
Black-legged tick
Isca\ISCW004041
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62271.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00740
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_66185
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_3736
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327633
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_253003
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307675
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_270167
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G013G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Xpo1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Xpo1h
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024562
Gallus gallus
Domestic chicken
Ggal\XPO1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ranbp21
4 of 10
ebo
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    XPO1; exportin 1
    13 of 15
    602559
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        emb - CG2064
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Cand1
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Dfd
        bimolecular fluorescence complementation, fluorescence microscopy
        (Duffraisse et al., 2020)
        emb - Ipo9
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Karyβ3
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - MRP
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Nup214
        anti bait coimmunoprecipitation, western blot, two hybrid, pull down, anti tag western blot
        (Xylourgidis et al., 2006)
        emb - Pp2A-29B
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Scamp
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Scr
        pull down, western blot, bimolecular fluorescence complementation, fluorescence microscopy
        (Duffraisse et al., 2020)
        emb - Sec61α
        experimental knowledge based
        (Guruharsha et al., 2011)
        emb - Ubx
        bimolecular fluorescence complementation, fluorescence microscopy, pull down, western blot
        (Duffraisse et al., 2020)
        emb - Z600
        anti bait coimmunoprecipitation, peptide massfingerprinting
        (Gawlinski et al., 2007)
        emb - tim
        pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot
        (Cai et al., 2021)
        RNA-protein
        Physical Interaction
        Assay
        References
        emb - polo
        pull down, Identification by mass spectrometry
        (Oliveira et al., 2019)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        emb
        suppressible
        mbo
        (Roth et al., 2003)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        hid
        enhanceable
        emb
        (Bilen and Bonini, 2007)
        External Data
        Subunit Structure (UniProtKB)
        Interacts with Clbn (via its N-terminus) (PubMed:16103875). Associates with the nuclear pore complex via interaction with mbo and Nup214 (PubMed:14638854, PubMed:17032737). Interacts with target proteins containing NES sequences such as actin and dl (PubMed:10924475, PubMed:14638854, PubMed:17032737).
        (UniProt, Q9TVM2 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-32
        Cytogenetic map
        29C1-29C3
        Sequence location
        2L:8,403,573..8,408,853 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        29C1-29C3
        Limits computationally determined from genome sequence between P{lacW}l(2)k12914k12914&P{lacW}Akap200k07118a and P{lacW}l(2)k03706k03706&P{lacW}Acerk07704
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        29C-29C
        (Hovemann, 1999.8.27)
        29C1-29C5
        (Fasken, 1999.9.28)
        29C1-29C2
        (Collier, 1999.8.23)
        29C3-29C4
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        29C3-29C4
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-32

        (FlyBase, 2016)

        2-27.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (21)
        cDNA Clones (117)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: emb l(2)k16715

        (Collier et al., 2000)
        Additional comments
        Other Comments

        sima protein nuclear export is affected in emb mutant embryos.

        (Irisarri et al., 2009)

        emb is involved in centriole duplication.

        (Dobbelaere et al., 2008)

        Mutations of the S.pombe crm1 are suppressed by expression of the Drosophila emb.

        (Collier et al., 1997)
        Origin and Etymology
        Discoverer
        Etymology

        The gene is named "embargoed" to reflect the nuclear export defects of the mutants.

        (Collier et al., 2000)
        Identification
        External Crossreferences and Linkouts ( 61 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB
        EMBL-EBI Single Cell Expression Atlas
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (21)
        Reported As
        Symbol Synonym
        CG13387
        (Hosono et al., 2015, Ding et al., 2014, Schertel et al., 2013, Christis and Munro, 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Mason and Goldfarb, 2009, Dobbelaere et al., 2008, Ni et al., 2008, Lippai et al., 2000)
        CRM1
        (Gamez et al., 2020, Irisarri et al., 2009, Sabri et al., 2007, Xylourgidis et al., 2006, Tootle and Rebay, 2005, Herold et al., 2003, Roth et al., 2003, Roth et al., 2003, Roth et al., 2003, Xylourgidis et al., 2003, Bienz, 2002, Fasken, 1999.9.28)
        Crm1
        (Kneuss et al., 2019, Freibaum et al., 2015, Kim et al., 2015, Büssing et al., 2010, Gawlinski et al., 2007, Song et al., 2005, Bono et al., 2004, Hieronymus and Silver, 2004, Hovemann, 1999.8.27, Collier and Gubb, 1997, Collier et al., 1997)
        DCRM1
        (Roth et al., 2003)
        Emb
        (Keegan and Hughes, 2021, Duffraisse et al., 2020, Oliveira et al., 2019, Sowa et al., 2018, Boeynaems et al., 2016, Schwartz et al., 2016, Finan et al., 2011, Büssing et al., 2010)
        XPO-1
        (Büssing et al., 2010)
        XPO1
        (Layalle et al., 2021, Swevers et al., 2018, Büssing et al., 2010)
        Xpo1
        (Chan et al., 2011)
        crm1
        (Nawathean and Rosbash, 2004, Tootle et al., 2003)
        dCRM1
        (Jin et al., 2012, Roth et al., 2003, Xylourgidis et al., 2003, Fasken et al., 2000)
        dXPO1
        (Yasunaga et al., 2014)
        emb
        (Evans et al., 2021, Cunningham et al., 2020, Okazaki et al., 2020, Meltzer et al., 2019, Mu et al., 2019, Steyaert et al., 2018, Solis et al., 2017, Transgenic RNAi Project members, 2017-, Lee et al., 2016, Schertel et al., 2013, Irisarri et al., 2009, Dobbelaere et al., 2008, McElroy et al., 2008, Bilen and Bonini, 2007, Bi et al., 2005)
        l(2)k16715
        (Spradling et al., 1999)
        xpo1
        (Cai et al., 2021)
        Name Synonyms
        Chromosomal region maintenance 1
        (Collier et al., 1997)
        Embargoed
        (Deivasigamani et al., 2014, Büssing et al., 2010)
        Exportin
        (Zhang et al., 2015, Bi et al., 2005, Bi et al., 2004)
        Exportin-1
        (Nie et al., 2009)
        embargoed
        (Hampoelz et al., 2019, Akan et al., 2016, Kimura and Imamoto, 2014, Yasunaga et al., 2014, Irisarri et al., 2009, Mason and Goldfarb, 2009, Bilen and Bonini, 2007, Bi et al., 2005, Roth et al., 2003)
        exportin
        (Jin et al., 2012)
        exportin-1
        (Chan et al., 2011)
        Secondary FlyBase IDs
        • FBgn0021807
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (107)