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Gene Dmel\Abi

General Information
Symbol	Dmel\Abi	Species	D. melanogaster
Name	Abelson interacting protein	Annotation symbol	CG9749
Feature type	protein_coding_gene	FlyBase ID	FBgn0020510
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dAbi, Ablphilin
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88A9-88A9	Sequence location	3R:9,944,984..9,948,142 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Abelson interacting protein is referred to in FlyBase by the symbol Dmel\Abi (CG9749, FBgn0020510). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 15 unique biological process terms, many of which group under: cellular component organization or biogenesis; single-organism developmental process; biological regulation; organelle organization; cell projection assembly; actin filament-based process; sensory organ development; localization; regulation of developmental process; positive regulation of cellular metabolic process; growth; muscle cell differentiation. 25 alleles are reported. The phenotypes of these alleles are annotated with: dorsocentral bristle; chaeta; longitudinal connective; scutellar bristle; sensory mother cell. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Abl-interactor, homeo-domain homologous domain; Neutrophil cytosol factor 2 p67phox; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632196_at partially aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Abi: 13 out of 14 probes fall into this exonic region. Gene sequence location is 3R:9944984..9948142.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88A9-88A9   Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88A-88B   (determined by in situ hybridisation)   (Gangadharan and Tear, 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Abi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Abi-RA FBtr0082910  NM_057915   2379   473 Abi-RB FBtr0112896  NM_001104315   2373   473 Abi-RC FBtr0307076  NM_001260161   2291   472 Abi-RD FBtr0307077  NM_001260162   2391   477 Abi-RE FBtr0337096  NM_001275630   2376   472 Abi-RF FBtr0337097  NM_001275631   2294   473
Additional Transcript Data & Comments
Reported size (kB)	1.7 (longest cDNA) (Juang and Hoffmann, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Abi-PA   FBpp0082371   51.9   473   6.93     NP_477263   AAF55021 Abi-PB   FBpp0111809   51.9   473   6.93     NP_001097785   ABW08669 Abi-PC   FBpp0297919   51.9   472   6.93     NP_001247090   AFH06408 Abi-PD   FBpp0297920   52.4   477   7.09     NP_001247091   AFH06409 Abi-PE   FBpp0308012   51.9   472   6.93     NP_001262559   AGB95940 Abi-PF   FBpp0308013   51.9   473   6.93     NP_001262560   AGB95941
Additional Polypeptide Data & Comments
Reported size (kDa)	473 (aa); 52 (kD observed) (Juang and Hoffmann, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) Src homology-3 domain (IPR001452) Abl-interactor, homeo-domain homologous domain (IPR012849)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA949993   AA951542   AE014297 AAF55021   AE014297 ABW08669   AC007441   AC007904   AF151115 AAD38382   AE014297 AFH06408   AE014297 AFH06409   AE014297 AGB95940   AE014297 AGB95941   AI456605   AI456858   AI457032   AI516875   AI516885   AI519260   AI531987   AI534023   AI534026   AI541715   AW943364   AY051877 AAK93301   BF506031   BG635570   BG636879   BI161716   BI161717   BI165171   BI212807   BI228726   BI228860   BI228874   BI236593   BI357029   BI361342   BI366630   BI368086   BI368437   BI372841   BI374470   BI483470   BI483788   BI485711   BI485937   BI486535   BI486663   BI577944   BI579310   BI580622   BI632194   BI638387   CK660561   CO155030   CO273172   CO279512   CO293212   CO296753   CO336187   EC075192   EC076432   EC083682   EC220126   EC235173   EC265053   EC267450   EV593215   GH755714   GH756151   GH770749   GH772152   GH774565   GH783527   GH786202   GH788109   GH789638   GH791756   GH795878   GH801610   GH802158   GH819328   GH821615   GH826623   GH835376   GH835482   GH863564   GH868881   GH872177   GH875092   GH881030   GH890305   GH895607   GH895895   GH896949   GH898094   GH899637   GH901315   GH905008   GH910311   GH913949   GH914623   GH923722   GH923964   GH926393   GH934196   GH935461
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9Y0S9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lamellipodium membrane inferred from direct assay (Huang et al., 2007) perinuclear region of cytoplasm inferred from direct assay (Huang et al., 2007) colocalizes_with protein complex inferred from physical interaction with WASp (Stephan et al., 2011) colocalizes_with SCAR complex inferred from physical interaction with SCAR, Hem (Stephan et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    356.475 Larval Midgut    296.4 Larval Hindgut    286.9 Larval Malpighian Tubules    225.8 Larval Fat Body    221.9 Larval Salivary Gland    306.4 Larval Trachea    255.4 Larval Carcass    288.125 Adult Head    152.9 Adult Eye    136.925 Adult Brain    262.1 Adult Thoracic-Abdominal Ganglion    219.4 Adult Crop    210.2 Adult Midgut    219.8 Adult Hindgut    212.1 Adult Malpighian Tubules    155.2 Adult Fat Body    158.3 Adult Salivary Gland    233.4 Adult Heart    147.025 Adult VirginFemale Spermatheca    149 Adult InseminatedFemale Spermatheca    156.4 Adult Ovary    307.4 Adult Testis    190.6 Adult Male Accessory Gland    231.1 Adult Carcass    144.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    152.9   NA  Eye    136.925   NA  Brain    262.1   356.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    219.4   NA  Crop    210.2   296.4  Midgut    219.8   286.9  Hindgut    212.1   225.8  Malpighian Tubules    155.2   221.9  Fat Body    158.3   306.4  Salivary Gland    233.4   NA  Heart    147.025   255.4  Trachea    NA   NA  VirginFemale Spermatheca    149   NA  InseminatedFemale Spermatheca    156.4   NA  Ovary    307.4   NA  Testis    190.6   NA  Male Accessory Gland    231.1   288.125  Carcass    144.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    67 central nervous system, larvae L3    72 central nervous system, pupae P8    78 head, virgin 1-day female    24 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    38 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    43 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    34 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    36 carcass, larvae L3 wandering    44 carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female    79 ovary, mated 4-day female    83 testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (67) central nervous system, larvae L3  (72) central nervous system, pupae P8  (78) head, virgin 1-day female    24 head, virgin 4-day female  (28) head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male  (33) head, mated 4-day male  (33) head, mated 20-day male  (38) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (27) digestive system, larvae L3 wandering  (43) digestive system, 1-day adult    23 digestive system, 4-day adult  26 digestive system, 20-day adult  (34) fat body, larvae L3 wandering    22 fat body, white prepupae  (29) fat body, pupae P8  (36) carcass, larvae L3 wandering  (44) carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female  (79) ovary, mated 4-day female  (83) testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    67 central nervous system, larvae L3    72 central nervous system, pupae P8    78 head, virgin 1-day female    24 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    38 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    43 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    34 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    36 carcass, larvae L3 wandering    44 carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female    79 ovary, mated 4-day female    83 testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    67 central nervous system, larvae L3    72 central nervous system, pupae P8    78 head, virgin 1-day female    24 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    38 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    43 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    34 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    36 carcass, larvae L3 wandering    44 carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female    79 ovary, mated 4-day female    83 testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    67 central nervous system, larvae L3    72 central nervous system, pupae P8    78 head, virgin 1-day female    24 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    38 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    43 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    34 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    36 carcass, larvae L3 wandering    44 carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female    79 ovary, mated 4-day female    83 testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (67) central nervous system, larvae L3  (72) central nervous system, pupae P8  (78) head, virgin 1-day female    24 head, virgin 4-day female  28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male  (33) head, mated 4-day male  (33) head, mated 20-day male  (38) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  27 digestive system, larvae L3 wandering  (43) digestive system, 1-day adult    23 digestive system, 4-day adult  26 digestive system, 20-day adult  (34) fat body, larvae L3 wandering    22 fat body, white prepupae  29 fat body, pupae P8  (36) carcass, larvae L3 wandering  (44) carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female  (79) ovary, mated 4-day female  (83) testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    67 central nervous system, larvae L3    72 central nervous system, pupae P8    78 head, virgin 1-day female    24 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    38 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    43 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    34 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    36 carcass, larvae L3 wandering    44 carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female    79 ovary, mated 4-day female    83 testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    67 central nervous system, larvae L3    72 central nervous system, pupae P8    78 head, virgin 1-day female    24 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    25 head, mated 4-day female    20 head, mated 20-day female    19 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    38 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    43 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    34 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    36 carcass, larvae L3 wandering    44 carcass, 1-day adult    16 carcass, 4-day adult    20 carcass, 20-day adult    22 ovary, virgin 4-day female    79 ovary, mated 4-day female    83 testis, mated 4-day male    25 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    80 embryo 08-10hr    74 embryo 10-12hr    65 embryo 12-14hr    57 embryo 14-16hr    46 embryo 16-18hr    37 embryo 18-20hr    33 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    34 white prepupae 24hr    40 pupae 2d postWPP    34 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (56) embryo 04-06hr  (57) embryo 06-08hr  (80) embryo 08-10hr  (74) embryo 10-12hr  (65) embryo 12-14hr  (57) embryo 14-16hr  (46) embryo 16-18hr  (37) embryo 18-20hr  (33) embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (28) white prepupae new  (32) white prepupae 12hr  (34) white prepupae 24hr  (40) pupae 2d postWPP  (34) pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day  (33) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    80 embryo 08-10hr    74 embryo 10-12hr    65 embryo 12-14hr    57 embryo 14-16hr    46 embryo 16-18hr    37 embryo 18-20hr    33 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    34 white prepupae 24hr    40 pupae 2d postWPP    34 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    80 embryo 08-10hr    74 embryo 10-12hr    65 embryo 12-14hr    57 embryo 14-16hr    46 embryo 16-18hr    37 embryo 18-20hr    33 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    34 white prepupae 24hr    40 pupae 2d postWPP    34 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    80 embryo 08-10hr    74 embryo 10-12hr    65 embryo 12-14hr    57 embryo 14-16hr    46 embryo 16-18hr    37 embryo 18-20hr    33 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    34 white prepupae 24hr    40 pupae 2d postWPP    34 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (56) embryo 04-06hr  (57) embryo 06-08hr  (80) embryo 08-10hr  (74) embryo 10-12hr  (65) embryo 12-14hr  (57) embryo 14-16hr  (46) embryo 16-18hr  (37) embryo 18-20hr  (33) embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  28 white prepupae new  32 white prepupae 12hr  (34) white prepupae 24hr  (40) pupae 2d postWPP  (34) pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day  (33) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    80 embryo 08-10hr    74 embryo 10-12hr    65 embryo 12-14hr    57 embryo 14-16hr    46 embryo 16-18hr    37 embryo 18-20hr    33 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    34 white prepupae 24hr    40 pupae 2d postWPP    34 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    80 embryo 08-10hr    74 embryo 10-12hr    65 embryo 12-14hr    57 embryo 14-16hr    46 embryo 16-18hr    37 embryo 18-20hr    33 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    21 larva L2    15 larva L3 12hr old    14 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    34 white prepupae 24hr    40 pupae 2d postWPP    34 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    17 adult male 05day    20 adult male 30day    19 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    86 embryonic 1182-4H    168 embryonic GM2    165 embryonic Kc167    128 embryonic S1    146 embryonic S3    88 leg disc CME L1    117 wing disc CME-W2    86 wing disc ML-DmD8    75 wing disc ML-DmD9    95 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    54 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    118 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    106 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    90 ovary fGS/OSS    79 ovary OSC    76 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (68) Schneider line 2 Sg4  (86) embryonic 1182-4H  (168) embryonic GM2  (165) embryonic Kc167  (128) embryonic S1  (146) embryonic S3  (88) leg disc CME L1  (117) wing disc CME-W2  (86) wing disc ML-DmD8  (75) wing disc ML-DmD9  (95) wing disc ML-DmD16-c3  (103) wing disc ML-DmD21  (54) wing disc ML-DmD32  (138) haltere disc ML-DmD17-c3  (118) eye-antennal disc ML-DmD11  (84) antennal disc ML-DmD20-c5  (96) mixed discs ML-DmD4-c1  (106) CNS ML-DmBG1-c1  (107) CNS ML-DmBG2-c2  (74) tumorous blood cells mbn2  (90) ovary fGS/OSS  (79) ovary OSC  (76) ovary OSS  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    86 embryonic 1182-4H  (168) embryonic GM2  (165) embryonic Kc167  (128) embryonic S1  (146) embryonic S3    88 leg disc CME L1  (117) wing disc CME-W2    86 wing disc ML-DmD8    75 wing disc ML-DmD9    95 wing disc ML-DmD16-c3  103 wing disc ML-DmD21    54 wing disc ML-DmD32  (138) haltere disc ML-DmD17-c3  (118) eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1  106 CNS ML-DmBG1-c1  107 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    90 ovary fGS/OSS    79 ovary OSC    76 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    86 embryonic 1182-4H    168 embryonic GM2    165 embryonic Kc167    128 embryonic S1    146 embryonic S3    88 leg disc CME L1    117 wing disc CME-W2    86 wing disc ML-DmD8    75 wing disc ML-DmD9    95 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    54 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    118 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    106 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    90 ovary fGS/OSS    79 ovary OSC    76 ovary OSS    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    86 embryonic 1182-4H    168 embryonic GM2    165 embryonic Kc167    128 embryonic S1    146 embryonic S3    88 leg disc CME L1    117 wing disc CME-W2    86 wing disc ML-DmD8    75 wing disc ML-DmD9    95 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    54 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    118 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    106 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    90 ovary fGS/OSS    79 ovary OSC    76 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (68) Schneider line 2 Sg4  (86) embryonic 1182-4H  (168) embryonic GM2  (165) embryonic Kc167  (128) embryonic S1  (146) embryonic S3  (88) leg disc CME L1  (117) wing disc CME-W2  (86) wing disc ML-DmD8  (75) wing disc ML-DmD9  (95) wing disc ML-DmD16-c3  (103) wing disc ML-DmD21  (54) wing disc ML-DmD32  (138) haltere disc ML-DmD17-c3  (118) eye-antennal disc ML-DmD11  (84) antennal disc ML-DmD20-c5  (96) mixed discs ML-DmD4-c1  (106) CNS ML-DmBG1-c1  (107) CNS ML-DmBG2-c2  (74) tumorous blood cells mbn2  (90) ovary fGS/OSS  (79) ovary OSC  (76) ovary OSS  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    86 embryonic 1182-4H  (168) embryonic GM2  (165) embryonic Kc167  128 embryonic S1  (146) embryonic S3    88 leg disc CME L1  117 wing disc CME-W2    86 wing disc ML-DmD8    75 wing disc ML-DmD9    95 wing disc ML-DmD16-c3  103 wing disc ML-DmD21    54 wing disc ML-DmD32  138 haltere disc ML-DmD17-c3  118 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1  106 CNS ML-DmBG1-c1  107 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    90 ovary fGS/OSS    79 ovary OSC    76 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    86 embryonic 1182-4H    168 embryonic GM2    165 embryonic Kc167    128 embryonic S1    146 embryonic S3    88 leg disc CME L1    117 wing disc CME-W2    86 wing disc ML-DmD8    75 wing disc ML-DmD9    95 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    54 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    118 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    106 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    90 ovary fGS/OSS    79 ovary OSC    76 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    28 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    64 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  (28) heat shock, 4-day adult  (42) Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult  (30) Ethanol 2.5% 3 hrs, larvae L3  (64) Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (72) Caffeine 25 mg/ml 48 hrs, 4-day adult  (34) Paraquat 5 mM 48 hrs, 4-day adult  (57) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    28 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    64 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    28 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    64 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    28 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    64 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  28 heat shock, 4-day adult  (42) Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult  30 Ethanol 2.5% 3 hrs, larvae L3  (64) Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (72) Caffeine 25 mg/ml 48 hrs, 4-day adult  (34) Paraquat 5 mM 48 hrs, 4-day adult  (57) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    28 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    64 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    28 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    64 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD37010 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020510 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9749-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | maternal effect | recessive Abiunspecified lethal | P-stage AbiΔ20 lethal | pupal stage (with AbiKO) AbiP2 lethal | pupal stage (with AbiP2) AbiKO lethal | pupal stage (with Df(3R)JY19) AbiKO AbiP2 lethal | recessive AbiKO viable, with Scer\GAL4pnr-MD237 AbiGD14302 Other Phenotypes Allele cell shape defective AbidsRNA.cKa neuroanatomy defective | embryonic stage (with AbiKO) AbiP2 neuroanatomy defective | embryonic stage (with AbiP2) AbiKO neuroanatomy defective | embryonic stage | maternal effect, with Df(3R)JY19/AbiP1 AbiP2 neuroanatomy defective | embryonic stage | maternal effect (with Df(3R)JY19), with AbiP2 AbiP1 neuroanatomy defective | recessive | third instar larval stage AbiΔ20 visible, with Scer\GAL4sca-537.4 AbidsRNA.Scer\UAS AbiScer\UAS.T:Myr-Src64B Phenotype manifest in Allele chaeta, with Scer\GAL4sca-537.4 AbidsRNA.Scer\UAS chaeta & mesothoracic tergum | ectopic, with Scer\GAL4sca-537.4 AbiScer\UAS.T:Myr-Src64B dorsocentral bristle, with Scer\GAL4sca-537.4 AbidsRNA.Scer\UAS filamentous actin | ectopic, with Scer\GAL4en-e16E AbiScer\UAS.T:Myr-Src64B lamina | third instar larval stage AbiΔ20 longitudinal connective (with AbiKO) AbiP2 longitudinal connective (with AbiP2) AbiKO longitudinal connective (with Df(3R)JY19) AbiKO longitudinal connective | maternal effect, with Df(3R)JY19/AbiP1 AbiP2 longitudinal connective | maternal effect (with Df(3R)JY19), with AbiP2 AbiP1 medulla | third instar larval stage AbiΔ20 notopleural bristle | supernumerary, with Scer\GAL4sca-537.4 AbiScer\UAS.T:Myr-Src64B outer photoreceptor cell | third instar larval stage AbiΔ20 photoreceptor cell R2 | third instar larval stage AbiΔ20 photoreceptor cell R3 | third instar larval stage AbiΔ20 photoreceptor cell R4 | third instar larval stage AbiΔ20 photoreceptor cell R5 | third instar larval stage AbiΔ20 presumptive embryonic/larval nervous system | maternal effect Abiunspecified scutellar bristle, with Scer\GAL4sca-537.4 AbidsRNA.Scer\UAS sensory mother cell, with Scer\GAL4sca-537.4 AbidsRNA.Scer\UAS sensory mother cell | supernumerary, with Scer\GAL4sca-537.4 AbiScer\UAS.T:Myr-Src64B tract | somatic clone | third instar larval stage AbiΔ20 tract | third instar larval stage AbiΔ20
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Abi Class Mutagen Stocks Known lesion AbiEY20423 P-element activity 1 -- AbiΔ20 amorphic allele - molecular evidence P-element activity 0 Yes AbiKO loss of function allele recombination ends-out gene targeting 0 Yes AbiP1 hypomorphic allele - genetic evidence 0 -- AbiP2 loss of function allele 0 -- Abiunspecified 0 --
Alleles Carried on Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Abi Class Mutagen Stocks Known lesion AbiGD14302 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AbiHMS01597 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AbiKK108071 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Abia.Act5C in vitro construct - regulatory fusion 0 Yes AbiAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AbidsRNA.cKa in vitro construct - RNAi 0 Yes AbidsRNA.cRa in vitro construct - RNAi 0 Yes AbidsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes AbiEndsOut.L in vitro construct 0 Yes AbiNIG.9749R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AbiScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes AbiScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AbiScer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AbiWAB-HHR.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes AbiΔC.Scer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AbiΔC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes AbiΔN.Scer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AbiΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes AbiΔSH3.Act5C.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7359 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14302} NA P{KK108071} NA P{NIG.9749R} NA P{TRiP.HMS01597} NA P{UAS-Abi.Myr} NA P{UAS-Abi.RNAi} NA P{UAS-Abi.ΔC.Myr} NA P{UAS-Abi.ΔN.Myr} NA P{UAS-Ani.S} NA P{UAS-Ani.WAB-HHR} NA P{UAS-Ani.ΔC} NA P{UAS-Ani.ΔN} NA P{UAS-GFP-Abi} NA characterization construct P{EndsOut-Abi.L} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}AbiP1 NA P{EP}AbiP2 NA P{EPgy2}AbiEY20423 NA
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 20 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Abl (Juang and Hoffmann, 1999) inferred from physical interaction with Hem AND inferred from physical interaction with WASp (Bogdan and Klambt, 2003) inferred from physical interaction with Ptp61F (Huang et al., 2007)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Bogdan et al., 2005, Lin et al., 2009) axon extension involved in axon guidance inferred from mutant phenotype (Stephan et al., 2011) cell adhesion inferred from mutant phenotype (Jani and Schock, 2007) cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) cell projection assembly inferred from mutant phenotype (Kunda et al., 2003) central nervous system neuron axonogenesis inferred from mutant phenotype (Lin et al., 2009) chaeta development inferred from mutant phenotype (Bogdan et al., 2005) cortical actin cytoskeleton organization inferred from mutant phenotype (Kunda et al., 2003) Golgi organization inferred from mutant phenotype (Kondylis et al., 2011) lamellipodium assembly inferred from mutant phenotype (Huang et al., 2007) muscle attachment inferred from mutant phenotype (Jani and Schock, 2007) neuromuscular junction development inferred from genetic interaction with Abl (Lin et al., 2009) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of protein kinase activity inferred from direct assay (Juang and Hoffmann, 1999) regulation of cell shape inferred from mutant phenotype (Kunda et al., 2003)
Cellular Component
CV term Evidence References
lamellipodium membrane inferred from direct assay (Huang et al., 2007) perinuclear region of cytoplasm inferred from direct assay (Huang et al., 2007) colocalizes_with protein complex inferred from physical interaction with WASp (Stephan et al., 2011) colocalizes_with SCAR complex inferred from physical interaction with SCAR, Hem (Stephan et al., 2011)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
signal transducer activity inferred from sequence or structural similarity with EMBL:U17698 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Abi allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66795 DroID - A comprehensive database of gene and protein interactions. • FBgn0020510 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41718 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9Y0S9
Orthologs
OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GJ07Z Dipteran inclusive ortholog search EOG628292 Insect inclusive ortholog search EOG615F8X Arthropod inclusive ortholog search EOG6ZGMTV Metazoa inclusive ortholog search EOG6PP99F
Orthologs in Drosophila Species (EOG6GJ07Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Abi     Drosophila simulans   Dsim\GD20455 Y   Drosophila sechellia   Dsec\GM25884 Y   Drosophila erecta   Dere\GG21491 Y   Drosophila yakuba   Dyak\GE10059 Y   Drosophila ananassae   Dana\GF18788 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22007 Y   Drosophila persimilis   Dper\GL23309 Y   Drosophila willistoni   Dwil\GK10907 Y   Drosophila virilis   Dvir\GJ22620 Y   Drosophila mojavensis   Dmoj\GI24554 Y   Drosophila grimshawi   Dgri\GH19698 Y
Orthologs in non-Drosophila Dipterans (EOG628292)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014130   Anopheles gambiae Malaria mosquito  Agam\AGAP001046   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006389   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018548
Orthologs in non-Dipteran Insects (EOG615F8X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Abi   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG033463   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019117   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15675   Atta cephalotes Leafcutter ant  Acep\ACEP14905   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21259   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14674   Linepithema humile Argentine ant  Lhum\LH17230   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21102   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10445   Solenopsis invicta Red fire ant  Sinv\SINV11798   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006331   Bombyx mori Silkmoth  Bmor\BGIBMGA012500   Pediculus humanus Human body louse  Phum\PHUM354390   Tribolium castaneum Red flour beetle  Tcas\TC000412
Orthologs in non-Insect Arthropods (EOG6ZGMTV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\benA   Ixodes scapularis Deer tick  Isca\ISCW002934
Orthologs in non-Arthropod Metazoa (EOG6PP99F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\abi-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027968gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016173gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014235gn   Danio rerio Zebrafish  Drer\abi1b   Danio rerio Zebrafish  Drer\DKEY-33M14.7   Danio rerio Zebrafish  Drer\abi1a   Danio rerio Zebrafish  Drer\zgc:136560   Danio rerio Zebrafish  Drer\ENSDARG00000063283   Xenopus tropicalis Western clawed frog  Xtro\abi1   Xenopus tropicalis Western clawed frog  Xtro\abi2   Gallus gallus Domestic chicken  Ggal\ABI3   Gallus gallus Domestic chicken  Ggal\ABI2   Gallus gallus Domestic chicken  Ggal\ABI1   Mus musculus House mouse  Mmus\Abi2   Mus musculus House mouse  Mmus\Abi3   Mus musculus House mouse  Mmus\Abi1   Rattus norvegicus Norway rat  Rnor\Abi1   Rattus norvegicus Norway rat  Rnor\Abi2   Rattus norvegicus Norway rat  Rnor\Abi3   Homo sapiens Human  Hsap\ENSG00000138443   Homo sapiens Human  Hsap\ENSG00000136754   Homo sapiens Human  Hsap\ABI3
Human Orthologs (3)
Gene OMIM HGNC Hsap\ENSG00000138443     Hsap\ENSG00000136754     Hsap\ABI3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20455 Drosophila sechellia Dsec\GM25884 Drosophila erecta Dere\GG21491 Drosophila yakuba Dyak\GE10059 Drosophila ananassae Dana\GF18788 Drosophila pseudoobscura pseudoobscura Dpse\GA22007 Drosophila persimilis Dper\GL23309 Drosophila willistoni Dwil\GK10907 Drosophila virilis Dvir\GJ22620 Drosophila mojavensis Dmoj\GI24554 Drosophila grimshawi Dgri\GH19698
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	23107 y1 w67c23; P{EPgy2}AbiEY20423 36707 y1 sc* v1; P{TRiP.HMS01597}attP2
VDRC	v100714 P{KK108071}VIE-260B v36142 w1118; P{GD14302}v36142/TM3
Genomic Clones ( 2 )
	BACR01H04 BACR10E03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 94 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD37010
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08382 GH27462 GH27474 LD28582 LD32090 LD36681 LD37245 LD38782 LP19221 RE05002 RE18046 RE26358 RE26514 RE26531 RE32665 RE43368 RE45519 RE52209 RE53996 RE54407 RE60026 RE62068 RE66372 RE66733 RE69046 RE69301 RE69977 RE70118 RE71721 RE73324 RE74838 SD03315 SD06474 SD06485 SD06754 SD13022 SD14693 SD20663 SD25837
Other clones	21376 64859 73075 104400 524359 557084 CK01.127C.F1 Dmel_neb_010030_0644_3575 EK109908 EK134920 EK202151 EK215105 EN05234 EN12021 RE01144 RP003019079 RP003026214 RP003043089 RP003061345 RP003095640 RP003141825 RP003168811 RP003176338 RP003211824 RP003213625 RP003229536 RP003231105 RP003239802 RP003243584 RP003244820 RP003288214 RP003309513 RP003324467 RP003347243 RP003347645 RP003349687 RP003380048 RP003423472 RP003430202 RP003441948 RP003446234 RP003460309 RP003472758 RP003509574 RP003509661 RP003524201 RP003572025 RP003632968 RP003645712 RP003649259 RP003652484 RP003655823 RP003676667 RP003678673
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020510 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41718
Antibody Information
	polyclonal (Gautier et al., 2011, Stephan et al., 2011, Georgiou and Baum, 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Abi CG9749 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057915 NM_001104315 NM_001260161 NM_001260162 NM_001275630 NM_001275631 RefSeq (Proteins) • NP_477263 NP_001097785 NP_001247090 NP_001247091 NP_001262559 NP_001262560 DDBJ / EMBL / GenBank • AAD38382 AAF55021 AAK93301 ABW08669 AC007441 AC007904 AF151115 AFH06408 AFH06409 AGB95940 AGB95941 AI456858 AW943364 AY051877 Entrez Gene - A searchable database of RefSeq genes. • 41718 UniProtKB/TrEMBL • Q9Y0S9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) Src homology-3 domain (IPR001452) Abl-interactor, homeo-domain homologous domain (IPR012849) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD37010
Linkouts
	BioGRID - A database of protein and genetic interactions • 66795 DroID - A comprehensive database of gene and protein interactions. • FBgn0020510 DRSC - Results from RNAi screens. • FBgn0020510 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020510 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9749-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020510 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41718 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/abi.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41718 modMine - Data generated by the modENCODE project. • FBgn0020510 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9Y0S9
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Abi (Rogers et al., 2003, Huang et al., 2007, Chen et al., 2007, Stroschein-Stevenson et al., 2006, Jani and Schock, 2007, Huang et al., 2007, Stephan et al., 2008, Bogdan et al., 2005, Zhu and Bhat, 2011, Ulvila et al., 2011, Elwell et al., 2008, Zhu and Bhat, 2011, Kondylis et al., 2007, Qurashi et al., 2007, Hilger et al., 2009, Gohl et al., 2010, Georgiou and Baum, 2010, D'Ambrosio and Vale, 2010, Japanese National Institute of Genetics, 2012.5.21, Reed et al., 2012) abi (Lin et al., 2009, Fricke et al., 2009, Kondylis et al., 2011, Stephan et al., 2011) Abi-1 (Tepass et al., 2002) Ablphilin (Gangadharan, 1999.9.16, Gangadharan and Tear, 1999) CG9749 (Ramet et al., 2002, Rogers et al., 2003, Ni et al., 2011.7.19, Keleman et al., 2009.8.5) dAbi (Wahlstrom et al., 2001, Juang and Hoffmann, 1999, Lin et al., 2004, Ismail et al., 2009, Wang et al., 2010)
Name Synonym	Abelson Interacting Protein (Juang et al., 1997) Abelson interacting protein (Lin et al., 2009, Wang et al., 2010) Abelson interactor (Stephan et al., 2008, Gohl et al., 2010, Stephan et al., 2011)
Secondary FlyBase IDs
References ( 64 )
Generate a list of	All references relating to this gene ( 64 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 7 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 7 )
	Reed et al., 2012, Cell. Microbiol. 14(4): 529--545 Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. [FBrf0217748] Gautier et al., 2011, J. Cell Sci. 124(20): 3414--3427 Clathrin is required for Scar/Wave-mediated lamellipodium formation. [FBrf0216441] Kondylis et al., 2011, PLoS ONE 6(2): e17173 Identification of ER Proteins Involved in the Functional Organisation of the Early Secretory Pathway in Drosophila Cells by a Targeted RNAi Screen. [FBrf0213167] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Ulvila et al., 2011, J. Leukoc. Biol. 89(5): 649--659 Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. [FBrf0214462] Zhu and Bhat, 2011, Dev. Biol. 357(2): 283--294 The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. [FBrf0214765] Zhu and Bhat, 2011, Mech. Dev. 128(7-10): 483--495 The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb. [FBrf0216763] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...