General Information Symbol Dmel\ AbiSpecies D. melanogaster Name Abelson interacting protein Annotation symbol CG9749 Feature type protein_coding_gene FlyBase ID FBgn0020510 Gene Model Status Current Stock availability 4 publicly
available Also Known As dAbi, Ablphilin Genomic Location Chromosome (arm) 3R Recombination map Cytogenetic map 88A9-88A9 Sequence location 3R:9,944,984..9,948,142 [-]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
Abelson interacting protein is referred to in FlyBase by the symbol
Dmel\Abi (CG9749, FBgn0020510). It is a protein_coding_gene from
Drosophila melanogaster . There is experimental evidence that it has the
molecular function : protein binding. There is experimental evidence for 15 unique
biological process terms, many of which group under: cellular component organization or biogenesis; single-organism developmental process; biological regulation; organelle organization; cell projection assembly; actin filament-based process; sensory organ development; localization; regulation of developmental process; positive regulation of cellular metabolic process; growth; muscle cell differentiation.
25 alleles are reported . The
phenotypes of these alleles are annotated with: dorsocentral bristle; chaeta; longitudinal connective; scutellar bristle; sensory mother cell. It has
6 annotated transcripts and
6 annotated polypeptides .
Protein features are: Abl-interactor, homeo-domain homologous domain; Neutrophil cytosol factor 2 p67phox; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632196_at partially aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Abi: 13 out of 14 probes fall into this exonic region. Gene sequence location is
3R:9944984..9948142 .
User Contributed Data External Summaries
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
88A-88B
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.48
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) 473 (aa); 52 (kD observed)
Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
inferred from direct assay
inferred from physical interaction with
WASp inferred from physical interaction with
SCAR ,
Hem Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
High
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
356.475
Larval Midgut
296.4
Larval Hindgut
286.9
Larval Malpighian Tubules
225.8
Larval Fat Body
221.9
Larval Salivary Gland
306.4
Larval Trachea
255.4
Larval Carcass
288.125
Adult Head
152.9
Adult Eye
136.925
Adult Brain
262.1
Adult Thoracic-Abdominal Ganglion
219.4
Adult Crop
210.2
Adult Midgut
219.8
Adult Hindgut
212.1
Adult Malpighian Tubules
155.2
Adult Fat Body
158.3
Adult Salivary Gland
233.4
Adult Heart
147.025
Adult VirginFemale Spermatheca
149
Adult InseminatedFemale Spermatheca
156.4
Adult Ovary
307.4
Adult Testis
190.6
Adult Male Accessory Gland
231.1
Adult Carcass
144.9
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
152.9
NA
Eye
136.925
NA
Brain
262.1
356.475
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
219.4
NA
Crop
210.2
296.4
Midgut
219.8
286.9
Hindgut
212.1
225.8
Malpighian Tubules
155.2
221.9
Fat Body
158.3
306.4
Salivary Gland
233.4
NA
Heart
147.025
255.4
Trachea
NA
NA
VirginFemale Spermatheca
149
NA
InseminatedFemale Spermatheca
156.4
NA
Ovary
307.4
NA
Testis
190.6
NA
Male Accessory Gland
231.1
288.125
Carcass
144.9
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
67
central nervous system, larvae L3
72
central nervous system, pupae P8
78
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
33
head, mated 4-day male
33
head, mated 20-day male
38
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
43
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
34
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
36
carcass, larvae L3 wandering
44
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
79
ovary, mated 4-day female
83
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(67)
central nervous system, larvae L3
(72)
central nervous system, pupae P8
(78)
head, virgin 1-day female
24
head, virgin 4-day female
(28)
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
(33)
head, mated 4-day male
(33)
head, mated 20-day male
(38)
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
(27)
digestive system, larvae L3 wandering
(43)
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
(34)
fat body, larvae L3 wandering
22
fat body, white prepupae
(29)
fat body, pupae P8
(36)
carcass, larvae L3 wandering
(44)
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
(79)
ovary, mated 4-day female
(83)
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
67
central nervous system, larvae L3
72
central nervous system, pupae P8
78
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
33
head, mated 4-day male
33
head, mated 20-day male
38
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
43
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
34
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
36
carcass, larvae L3 wandering
44
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
79
ovary, mated 4-day female
83
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
67
central nervous system, larvae L3
72
central nervous system, pupae P8
78
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
33
head, mated 4-day male
33
head, mated 20-day male
38
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
43
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
34
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
36
carcass, larvae L3 wandering
44
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
79
ovary, mated 4-day female
83
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
67
central nervous system, larvae L3
72
central nervous system, pupae P8
78
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
33
head, mated 4-day male
33
head, mated 20-day male
38
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
43
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
34
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
36
carcass, larvae L3 wandering
44
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
79
ovary, mated 4-day female
83
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(67)
central nervous system, larvae L3
(72)
central nervous system, pupae P8
(78)
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
(33)
head, mated 4-day male
(33)
head, mated 20-day male
(38)
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
(43)
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
(34)
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
(36)
carcass, larvae L3 wandering
(44)
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
(79)
ovary, mated 4-day female
(83)
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
67
central nervous system, larvae L3
72
central nervous system, pupae P8
78
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
33
head, mated 4-day male
33
head, mated 20-day male
38
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
43
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
34
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
36
carcass, larvae L3 wandering
44
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
79
ovary, mated 4-day female
83
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
67
central nervous system, larvae L3
72
central nervous system, pupae P8
78
head, virgin 1-day female
24
head, virgin 4-day female
28
head, virgin 20-day female
19
head, mated 1-day female
25
head, mated 4-day female
20
head, mated 20-day female
19
head, mated 1-day male
33
head, mated 4-day male
33
head, mated 20-day male
38
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
27
digestive system, larvae L3 wandering
43
digestive system, 1-day adult
23
digestive system, 4-day adult
26
digestive system, 20-day adult
34
fat body, larvae L3 wandering
22
fat body, white prepupae
29
fat body, pupae P8
36
carcass, larvae L3 wandering
44
carcass, 1-day adult
16
carcass, 4-day adult
20
carcass, 20-day adult
22
ovary, virgin 4-day female
79
ovary, mated 4-day female
83
testis, mated 4-day male
25
accessory gland, mated 4-day male
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
58
embryo 02-04hr
56
embryo 04-06hr
57
embryo 06-08hr
80
embryo 08-10hr
74
embryo 10-12hr
65
embryo 12-14hr
57
embryo 14-16hr
46
embryo 16-18hr
37
embryo 18-20hr
33
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
34
white prepupae 24hr
40
pupae 2d postWPP
34
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
33
adult female 30day
35
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(58)
embryo 02-04hr
(56)
embryo 04-06hr
(57)
embryo 06-08hr
(80)
embryo 08-10hr
(74)
embryo 10-12hr
(65)
embryo 12-14hr
(57)
embryo 14-16hr
(46)
embryo 16-18hr
(37)
embryo 18-20hr
(33)
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
(28)
white prepupae new
(32)
white prepupae 12hr
(34)
white prepupae 24hr
(40)
pupae 2d postWPP
(34)
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
(33)
adult female 30day
(35)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
58
embryo 02-04hr
56
embryo 04-06hr
57
embryo 06-08hr
80
embryo 08-10hr
74
embryo 10-12hr
65
embryo 12-14hr
57
embryo 14-16hr
46
embryo 16-18hr
37
embryo 18-20hr
33
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
34
white prepupae 24hr
40
pupae 2d postWPP
34
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
33
adult female 30day
35
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
58
embryo 02-04hr
56
embryo 04-06hr
57
embryo 06-08hr
80
embryo 08-10hr
74
embryo 10-12hr
65
embryo 12-14hr
57
embryo 14-16hr
46
embryo 16-18hr
37
embryo 18-20hr
33
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
34
white prepupae 24hr
40
pupae 2d postWPP
34
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
33
adult female 30day
35
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
58
embryo 02-04hr
56
embryo 04-06hr
57
embryo 06-08hr
80
embryo 08-10hr
74
embryo 10-12hr
65
embryo 12-14hr
57
embryo 14-16hr
46
embryo 16-18hr
37
embryo 18-20hr
33
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
34
white prepupae 24hr
40
pupae 2d postWPP
34
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
33
adult female 30day
35
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(58)
embryo 02-04hr
(56)
embryo 04-06hr
(57)
embryo 06-08hr
(80)
embryo 08-10hr
(74)
embryo 10-12hr
(65)
embryo 12-14hr
(57)
embryo 14-16hr
(46)
embryo 16-18hr
(37)
embryo 18-20hr
(33)
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
(34)
white prepupae 24hr
(40)
pupae 2d postWPP
(34)
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
(33)
adult female 30day
(35)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
58
embryo 02-04hr
56
embryo 04-06hr
57
embryo 06-08hr
80
embryo 08-10hr
74
embryo 10-12hr
65
embryo 12-14hr
57
embryo 14-16hr
46
embryo 16-18hr
37
embryo 18-20hr
33
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
34
white prepupae 24hr
40
pupae 2d postWPP
34
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
33
adult female 30day
35
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
58
embryo 02-04hr
56
embryo 04-06hr
57
embryo 06-08hr
80
embryo 08-10hr
74
embryo 10-12hr
65
embryo 12-14hr
57
embryo 14-16hr
46
embryo 16-18hr
37
embryo 18-20hr
33
embryo 20-22hr
21
embryo 22-24hr
24
larva L1
21
larva L2
15
larva L3 12hr old
14
larva L3 puffstage 1-2
14
larva L3 puffstage 3-6
22
larva L3 puffstage 7-9
28
white prepupae new
32
white prepupae 12hr
34
white prepupae 24hr
40
pupae 2d postWPP
34
pupae 3d postWPP
22
pupae 4d postWPP
14
adult male 01day
17
adult male 05day
20
adult male 30day
19
adult female 01day
24
adult female 05day
33
adult female 30day
35
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
68
Schneider line 2 Sg4
86
embryonic 1182-4H
168
embryonic GM2
165
embryonic Kc167
128
embryonic S1
146
embryonic S3
88
leg disc CME L1
117
wing disc CME-W2
86
wing disc ML-DmD8
75
wing disc ML-DmD9
95
wing disc ML-DmD16-c3
103
wing disc ML-DmD21
54
wing disc ML-DmD32
138
haltere disc ML-DmD17-c3
118
eye-antennal disc ML-DmD11
84
antennal disc ML-DmD20-c5
96
mixed discs ML-DmD4-c1
106
CNS ML-DmBG1-c1
107
CNS ML-DmBG2-c2
74
tumorous blood cells mbn2
90
ovary fGS/OSS
79
ovary OSC
76
ovary OSS
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(68)
Schneider line 2 Sg4
(86)
embryonic 1182-4H
(168)
embryonic GM2
(165)
embryonic Kc167
(128)
embryonic S1
(146)
embryonic S3
(88)
leg disc CME L1
(117)
wing disc CME-W2
(86)
wing disc ML-DmD8
(75)
wing disc ML-DmD9
(95)
wing disc ML-DmD16-c3
(103)
wing disc ML-DmD21
(54)
wing disc ML-DmD32
(138)
haltere disc ML-DmD17-c3
(118)
eye-antennal disc ML-DmD11
(84)
antennal disc ML-DmD20-c5
(96)
mixed discs ML-DmD4-c1
(106)
CNS ML-DmBG1-c1
(107)
CNS ML-DmBG2-c2
(74)
tumorous blood cells mbn2
(90)
ovary fGS/OSS
(79)
ovary OSC
(76)
ovary OSS
(30)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
68
Schneider line 2 Sg4
86
embryonic 1182-4H
(168)
embryonic GM2
(165)
embryonic Kc167
(128)
embryonic S1
(146)
embryonic S3
88
leg disc CME L1
(117)
wing disc CME-W2
86
wing disc ML-DmD8
75
wing disc ML-DmD9
95
wing disc ML-DmD16-c3
103
wing disc ML-DmD21
54
wing disc ML-DmD32
(138)
haltere disc ML-DmD17-c3
(118)
eye-antennal disc ML-DmD11
84
antennal disc ML-DmD20-c5
96
mixed discs ML-DmD4-c1
106
CNS ML-DmBG1-c1
107
CNS ML-DmBG2-c2
74
tumorous blood cells mbn2
90
ovary fGS/OSS
79
ovary OSC
76
ovary OSS
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
68
Schneider line 2 Sg4
86
embryonic 1182-4H
168
embryonic GM2
165
embryonic Kc167
128
embryonic S1
146
embryonic S3
88
leg disc CME L1
117
wing disc CME-W2
86
wing disc ML-DmD8
75
wing disc ML-DmD9
95
wing disc ML-DmD16-c3
103
wing disc ML-DmD21
54
wing disc ML-DmD32
138
haltere disc ML-DmD17-c3
118
eye-antennal disc ML-DmD11
84
antennal disc ML-DmD20-c5
96
mixed discs ML-DmD4-c1
106
CNS ML-DmBG1-c1
107
CNS ML-DmBG2-c2
74
tumorous blood cells mbn2
90
ovary fGS/OSS
79
ovary OSC
76
ovary OSS
30
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
68
Schneider line 2 Sg4
86
embryonic 1182-4H
168
embryonic GM2
165
embryonic Kc167
128
embryonic S1
146
embryonic S3
88
leg disc CME L1
117
wing disc CME-W2
86
wing disc ML-DmD8
75
wing disc ML-DmD9
95
wing disc ML-DmD16-c3
103
wing disc ML-DmD21
54
wing disc ML-DmD32
138
haltere disc ML-DmD17-c3
118
eye-antennal disc ML-DmD11
84
antennal disc ML-DmD20-c5
96
mixed discs ML-DmD4-c1
106
CNS ML-DmBG1-c1
107
CNS ML-DmBG2-c2
74
tumorous blood cells mbn2
90
ovary fGS/OSS
79
ovary OSC
76
ovary OSS
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(68)
Schneider line 2 Sg4
(86)
embryonic 1182-4H
(168)
embryonic GM2
(165)
embryonic Kc167
(128)
embryonic S1
(146)
embryonic S3
(88)
leg disc CME L1
(117)
wing disc CME-W2
(86)
wing disc ML-DmD8
(75)
wing disc ML-DmD9
(95)
wing disc ML-DmD16-c3
(103)
wing disc ML-DmD21
(54)
wing disc ML-DmD32
(138)
haltere disc ML-DmD17-c3
(118)
eye-antennal disc ML-DmD11
(84)
antennal disc ML-DmD20-c5
(96)
mixed discs ML-DmD4-c1
(106)
CNS ML-DmBG1-c1
(107)
CNS ML-DmBG2-c2
(74)
tumorous blood cells mbn2
(90)
ovary fGS/OSS
(79)
ovary OSC
(76)
ovary OSS
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
68
Schneider line 2 Sg4
86
embryonic 1182-4H
(168)
embryonic GM2
(165)
embryonic Kc167
128
embryonic S1
(146)
embryonic S3
88
leg disc CME L1
117
wing disc CME-W2
86
wing disc ML-DmD8
75
wing disc ML-DmD9
95
wing disc ML-DmD16-c3
103
wing disc ML-DmD21
54
wing disc ML-DmD32
138
haltere disc ML-DmD17-c3
118
eye-antennal disc ML-DmD11
84
antennal disc ML-DmD20-c5
96
mixed discs ML-DmD4-c1
106
CNS ML-DmBG1-c1
107
CNS ML-DmBG2-c2
74
tumorous blood cells mbn2
90
ovary fGS/OSS
79
ovary OSC
76
ovary OSS
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
68
Schneider line 2 Sg4
86
embryonic 1182-4H
168
embryonic GM2
165
embryonic Kc167
128
embryonic S1
146
embryonic S3
88
leg disc CME L1
117
wing disc CME-W2
86
wing disc ML-DmD8
75
wing disc ML-DmD9
95
wing disc ML-DmD16-c3
103
wing disc ML-DmD21
54
wing disc ML-DmD32
138
haltere disc ML-DmD17-c3
118
eye-antennal disc ML-DmD11
84
antennal disc ML-DmD20-c5
96
mixed discs ML-DmD4-c1
106
CNS ML-DmBG1-c1
107
CNS ML-DmBG2-c2
74
tumorous blood cells mbn2
90
ovary fGS/OSS
79
ovary OSC
76
ovary OSS
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
41
cold shock, 4-day adult
28
heat shock, 4-day adult
42
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
35
Cadmium 100 mM 48 hrs, 4-day adult
70
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
35
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
64
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
72
Caffeine 25 mg/ml 48 hrs, 4-day adult
34
Paraquat 5 mM 48 hrs, 4-day adult
57
Paraquat 10 mM 48 hrs, 4-day adult
57
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(41)
cold shock, 4-day adult
(28)
heat shock, 4-day adult
(42)
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
(35)
Cadmium 100 mM 48 hrs, 4-day adult
(70)
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
(35)
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
(30)
Ethanol 2.5% 3 hrs, larvae L3
(64)
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(72)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(34)
Paraquat 5 mM 48 hrs, 4-day adult
(57)
Paraquat 10 mM 48 hrs, 4-day adult
(57)
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
41
cold shock, 4-day adult
28
heat shock, 4-day adult
42
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
35
Cadmium 100 mM 48 hrs, 4-day adult
70
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
35
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
64
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
72
Caffeine 25 mg/ml 48 hrs, 4-day adult
34
Paraquat 5 mM 48 hrs, 4-day adult
57
Paraquat 10 mM 48 hrs, 4-day adult
57
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
41
cold shock, 4-day adult
28
heat shock, 4-day adult
42
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
35
Cadmium 100 mM 48 hrs, 4-day adult
70
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
35
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
64
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
72
Caffeine 25 mg/ml 48 hrs, 4-day adult
34
Paraquat 5 mM 48 hrs, 4-day adult
57
Paraquat 10 mM 48 hrs, 4-day adult
57
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
41
cold shock, 4-day adult
28
heat shock, 4-day adult
42
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
35
Cadmium 100 mM 48 hrs, 4-day adult
70
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
35
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
64
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
72
Caffeine 25 mg/ml 48 hrs, 4-day adult
34
Paraquat 5 mM 48 hrs, 4-day adult
57
Paraquat 10 mM 48 hrs, 4-day adult
57
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(41)
cold shock, 4-day adult
28
heat shock, 4-day adult
(42)
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
(35)
Cadmium 100 mM 48 hrs, 4-day adult
(70)
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
(35)
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
(64)
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(72)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(34)
Paraquat 5 mM 48 hrs, 4-day adult
(57)
Paraquat 10 mM 48 hrs, 4-day adult
(57)
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
41
cold shock, 4-day adult
28
heat shock, 4-day adult
42
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
35
Cadmium 100 mM 48 hrs, 4-day adult
70
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
35
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
64
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
72
Caffeine 25 mg/ml 48 hrs, 4-day adult
34
Paraquat 5 mM 48 hrs, 4-day adult
57
Paraquat 10 mM 48 hrs, 4-day adult
57
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
41
cold shock, 4-day adult
28
heat shock, 4-day adult
42
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
20
Cadmium 50 mM 48 hrs, 4-day adult
35
Cadmium 100 mM 48 hrs, 4-day adult
70
Copper 0.5 mM 12 hrs, larvae L3
23
Copper 15 mM 48 hrs, 4-day adult
35
Zinc 5 mM 12 hrs, larvae L3
25
Zinc 4.5 mM 48 hrs, 4-day adult
30
Ethanol 2.5% 3 hrs, larvae L3
64
Ethanol 5% 3 hrs, larvae L3
24
Ethanol 10% 3 hrs, larvae L3
24
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
72
Caffeine 25 mg/ml 48 hrs, 4-day adult
34
Paraquat 5 mM 48 hrs, 4-day adult
57
Paraquat 10 mM 48 hrs, 4-day adult
57
Rotenone 2 μg 12 hrs, larvae L3
23
Rotenone 8 μg 12 hrs, larvae L3
24
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 6 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 19 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs UAS construct
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
characterization construct
Insertions insertion of mobile activating element
Gene Ontology: Function, Process
& Cellular Component ( 21 unique terms ) Terms Based on
Experimental Evidence ( 20 terms ) Molecular Function inferred from physical interaction with
Abl inferred from physical interaction with
Hem AND inferred from physical interaction with
WASp inferred from physical interaction with
Ptp61F Biological Process inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with
Abl inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Cellular Component inferred from direct assay
inferred from direct assay
inferred from physical interaction with
WASp inferred from physical interaction with
SCAR ,
Hem Terms Based on Predictions or
Assertions ( 1 term ) Molecular Function inferred from sequence or structural similarity with
EMBL:U17698 Biological Process ( 0 terms) Cellular Component ( 0 terms) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.
Orthologs
OrthoDB Orthologs (56)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6GJ07Z )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG628292 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG615F8X )
Apis mellifera
Western honey bee
Amel\Abi
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG033463
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019117
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH15675
Atta cephalotes
Leafcutter ant
Acep\ACEP14905
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO21259
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL14674
Linepithema humile
Argentine ant
Lhum\LH17230
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB21102
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB10445
Solenopsis invicta
Red fire ant
Sinv\SINV11798
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6ZGMTV )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6PP99F )
Caenorhabditis elegans
Nematode
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Rattus norvegicus
Norway rat
Rattus norvegicus
Norway rat
Human Orthologs (3)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 4 )Bloomington VDRC Genomic Clones ( 2 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 94 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for identity of: Abi CG9749
Source for database merge of Additional comments Other Comments S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
- A cyberspace guide to Drosophila development and metazoan evolution
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
- A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.
Synonyms & Secondary IDs
( 9 )Reported As Symbol Synonym Abi
(
Rogers et al., 2003 ,
Huang et al., 2007 ,
Chen et al., 2007 ,
Stroschein-Stevenson et al., 2006 ,
Jani and Schock, 2007 ,
Huang et al., 2007 ,
Stephan et al., 2008 ,
Bogdan et al., 2005 ,
Zhu and Bhat, 2011 ,
Ulvila et al., 2011 ,
Elwell et al., 2008 ,
Zhu and Bhat, 2011 ,
Kondylis et al., 2007 ,
Qurashi et al., 2007 ,
Hilger et al., 2009 ,
Gohl et al., 2010 ,
Georgiou and Baum, 2010 ,
D'Ambrosio and Vale, 2010 ,
Japanese National Institute of Genetics, 2012.5.21 ,
Reed et al., 2012 )
Name Synonym Abelson Interacting Protein
Abelson interacting protein
Secondary FlyBase
IDs References ( 64 )Generate a list of List References by type
Recent research papers ( 7 )
Reed et al., 2012, Cell. Microbiol. 14(4): 529--545Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. [FBrf0217748] Gautier et al., 2011, J. Cell Sci. 124(20): 3414--3427Clathrin is required for Scar/Wave-mediated lamellipodium formation. [FBrf0216441] Kondylis et al., 2011, PLoS ONE 6(2): e17173Identification of ER Proteins Involved in the Functional Organisation of the Early Secretory Pathway in Drosophila Cells by a Targeted RNAi Screen. [FBrf0213167] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Ulvila et al., 2011, J. Leukoc. Biol. 89(5): 649--659Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. [FBrf0214462] Zhu and Bhat, 2011, Dev. Biol. 357(2): 283--294The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. [FBrf0214765] Zhu and Bhat, 2011, Mech. Dev. 128(7-10): 483--495The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb. [FBrf0216763]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011