FB2020_01, released Feb 12, 2020

Gene: Dmel\Abi

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General Information
Symbol
Dmel\Abi
Species
D. melanogaster
Name
Abelson interacting protein
Annotation Symbol
CG9749
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020510
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

dAbi, Abelson interactor, Ablphilin

Key Links
Genomic Location
Cytogenetic map
88A9-88A9
Sequence location
3R:14,119,262..14,122,420 [-]
Recombination map

3-54

RefSeq locus
NT_033777 REGION:14119262..14122420
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
cadherin binding; protein binding
Predictions / Assertions
SH3 domain binding
Summaries
Gene Group (FlyBase)
WAVE REGULATORY COMPLEX -
The WAVE Regulatory Complex (WRC) is a multi-subunit complex that controls actin cytoskeletal dynamics. WRC activates the Arp2/3-mediated actin nucleation. WRC contains the nucleation-promoting factor SCAR, a member of the WASP family. (Adapted from FBrf0208042 and FBrf0224564).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\Abi or the JBrowse view of Dmel\Abi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Abi-RA
FBtr0082910
NM_057915
2379
473
Abi-RB
FBtr0112896
NM_001104315
2373
473
Abi-RC
FBtr0307076
NM_001260161
2291
472
Abi-RD
FBtr0307077
NM_001260162
2391
477
Abi-RE
FBtr0337096
NM_001275630
2376
472
Abi-RF
FBtr0337097
NM_001275631
2294
473
Additional Transcript Data and Comments
Reported size (kB)

1.7 (longest cDNA)

(Juang and Hoffmann, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Abi-PA
FBpp0082371
51.9
473
6.93
NP_477263
AAF55021
Abi-PB
FBpp0111809
51.9
473
6.93
NP_001097785
ABW08669
Abi-PC
FBpp0297919
51.9
472
6.93
NP_001247090
AFH06408
Abi-PD
FBpp0297920
52.4
477
7.09
NP_001247091
AFH06409
Abi-PE
FBpp0308012
51.9
472
6.93
NP_001262559
AGB95940
Abi-PF
FBpp0308013
51.9
473
6.93
NP_001262560
AGB95941
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

473 aa isoforms: Abi-PA, Abi-PB, Abi-PF
472 aa isoforms: Abi-PC, Abi-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

473 (aa); 52 (kD observed)

(Juang and Hoffmann, 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Abi using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (32 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cadherin binding
inferred from physical interaction with UniProtKB:Q9VW71
(Squarr et al., 2016)
protein binding
inferred from physical interaction with FLYBASE:ena; FB:FBgn0000578
(Chen et al., 2014)
(assigned by UniProt )
(Chia et al., 2014)
inferred from physical interaction with FLYBASE:Abl; FB:FBgn0000017
(Juang and Hoffmann, 1999)
inferred from physical interaction with FLYBASE:Ptp61F; FB:FBgn0267487
(Huang et al., 2007)
inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771
(Bogdan and Klambt, 2003)
inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
(Bogdan and Klambt, 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
SH3 domain binding
inferred from biological aspect of ancestor with PANTHER:PTN000048906
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (22 terms)
Terms Based on Experimental Evidence (22 terms)
CV Term
Evidence
References
actin cytoskeleton organization
inferred from mutant phenotype
(Lin et al., 2009, Bogdan et al., 2005)
axon extension involved in axon guidance
inferred from mutant phenotype
(Stephan et al., 2011)
cell adhesion
inferred from mutant phenotype
(Jani and Schock, 2007)
cell adhesion mediated by integrin
inferred from mutant phenotype
(Gohl et al., 2010)
cell morphogenesis
inferred from mutant phenotype
(D'Ambrosio and Vale, 2010)
cell projection assembly
inferred from mutant phenotype
(Kunda et al., 2003)
central nervous system neuron axonogenesis
inferred from mutant phenotype
(Lin et al., 2009)
centripetally migrating follicle cell migration
inferred from mutant phenotype
(Squarr et al., 2016)
chaeta development
inferred from mutant phenotype
(Stephan et al., 2008, Bogdan et al., 2005)
cortical actin cytoskeleton organization
inferred from mutant phenotype
(Kunda et al., 2003)
establishment of planar polarity of follicular epithelium
inferred from mutant phenotype
(Squarr et al., 2016)
lamellipodium assembly
inferred from mutant phenotype
(Huang et al., 2007)
muscle attachment
inferred from mutant phenotype
(Jani and Schock, 2007)
neuromuscular junction development
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
(Lin et al., 2009)
oogenesis
inferred from mutant phenotype
(Chen et al., 2014, Chen et al., 2014)
photoreceptor cell axon guidance
inferred from mutant phenotype
(Chen et al., 2014)
positive regulation of cytoskeleton organization
inferred from mutant phenotype
(Chen et al., 2014)
positive regulation of filopodium assembly
inferred from mutant phenotype
(Squarr et al., 2016)
positive regulation of protein kinase activity
inferred from direct assay
(Juang and Hoffmann, 1999)
positive regulation of stress fiber assembly
inferred from mutant phenotype
(Squarr et al., 2016)
regulation of actin cytoskeleton organization
inferred from mutant phenotype
(Chen et al., 2014)
regulation of cell shape
inferred from mutant phenotype
(Kunda et al., 2003)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
actin-based cell projection
inferred from direct assay
(Squarr et al., 2016)
basal cortex
inferred from direct assay
(Squarr et al., 2016)
basal part of cell
inferred from direct assay
(Gohl et al., 2010)
lamellipodium membrane
inferred from direct assay
(Huang et al., 2007)
perinuclear region of cytoplasm
inferred from direct assay
(Huang et al., 2007)
protein-containing complex
inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
(Stephan et al., 2011)
SCAR complex
inferred from direct assay
(Chen et al., 2014)
inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771, FLYBASE:SCAR; FB:FBgn0041781
(Stephan et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
eye photoreceptor cell
• axon
(Stephan et al., 2011)
medulla
(Stephan et al., 2011)
lamina
(Stephan et al., 2011)
embryonic stage 17
commissure
(Lin et al., 2009)
longitudinal connective
(Lin et al., 2009)
midline
(Lin et al., 2009)
third instar larval stage
ventral nerve cord
(Lin et al., 2009)
embryonic/larval brain
(Lin et al., 2009)
embryonic/larval optic lobe
(Lin et al., 2009)
embryonic/larval optic stalk
(Lin et al., 2009)
photoreceptor cell
(Lin et al., 2009)
synaptic neuropil
(Lin et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval brain
(Stephan et al., 2011)
Additional Descriptive Data

Abi is expressed in the brain and ventral nerve cord of the embryonic CNS, specifically in the commissures and longitudinal connectives. There is also some staining along the midline. In third instar larvae expression is observed in several regions of the brain including the neuropil, in axon fascicles of the ventral nerve cord, in photoreceptor cells in the eye disc, and in photoreceptor axons projecting through the optic stalk into the optic lobe.

(Lin et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
actin-based cell projection
inferred from direct assay
(Squarr et al., 2016)
basal cortex
inferred from direct assay
(Squarr et al., 2016)
basal part of cell
inferred from direct assay
(Gohl et al., 2010)
lamellipodium membrane
inferred from direct assay
(Huang et al., 2007)
perinuclear region of cytoplasm
inferred from direct assay
(Huang et al., 2007)
protein-containing complex
inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
(Stephan et al., 2011)
SCAR complex
inferred from direct assay
(Chen et al., 2014)
inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771, FLYBASE:SCAR; FB:FBgn0041781
(Stephan et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Abi in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Abi
Transgenic constructs containing regulatory region of Abi
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of embryonic stage | germline clone | maternal effect | recessive
lethal - all die before end of P-stage
lethal - all die before end of pupal stage (with AbiKO)
lethal - all die before end of pupal stage (with AbiP2)
lethal - all die before end of pupal stage (with Df(3R)JY19)
lethal - all die during P-stage (with Df(3R)su(Hw)7)
partially lethal - majority die, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155
partially lethal - majority die, with Abi5/Df(3R)su(Hw)7, Scer\GAL4how-24B
partially lethal - majority die (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155
partially lethal - majority die (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4how-24B
partially lethal - majority live, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155, Scer\GAL4how-24B
partially lethal - majority live (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155, Scer\GAL4how-24B
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female fertile, with Scer\GAL4da.PU
female semi-sterile, with AbiUASp.AW, Scer\GAL4da.PU
female semi-sterile, with AbiUASp.cCa, Scer\GAL4da.PU
female semi-sterile, with AbiΔ20, Scer\GAL4da.PU
female sterile, with AbiUAS.cSa, Scer\GAL4da.PU
female sterile, with AbiUASp.ΔEna, Scer\GAL4da.PU
female sterile, with AbiΔ20, Scer\GAL4da.PU
Other Phenotypes
Allele
cell migration defective, with AbiΔ20, Scer\GAL4da.PU
cell migration defective, with AbiΔWIRS.UAS, Scer\GAL4da.PU
cell polarity defective, with AbiΔ20, Scer\GAL4da.PU
cell polarity defective, with AbiΔWIRS.UAS, Scer\GAL4da.PU
flight defective, with Scer\GAL4Mef2.PR
majority die during P-stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155
majority die during P-stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4how-24B
majority die during P-stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155
majority die during P-stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4how-24B
neuroanatomy defective
neuroanatomy defective | embryonic stage (with AbiKO)
neuroanatomy defective | embryonic stage (with AbiP2)
neuroanatomy defective | embryonic stage | maternal effect, with Df(3R)JY19/AbiP1
neuroanatomy defective | embryonic stage | maternal effect (with Df(3R)JY19), with AbiP2
neuroanatomy defective | recessive | third instar larval stage
neuroanatomy defective | third instar larval stage
neuroanatomy defective | third instar larval stage (with Df(3R)su(Hw)7)
neurophysiology defective | third instar larval stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4Abi.PK
neurophysiology defective | third instar larval stage (with Df(3R)su(Hw)7)
neurophysiology defective | third instar larval stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4Abi.PK
some die during embryonic stage | maternal effect | recessive
some die during P-stage
some die during P-stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155, Scer\GAL4how-24B
some die during P-stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155, Scer\GAL4how-24B
some die during pupal stage (with AbiKO)
some die during pupal stage (with AbiP2)
some die during pupal stage (with Df(3R)JY19)
uncoordinated (with Df(3R)su(Hw)7)
visible, with Scer\GAL4sca-537.4
Phenotype manifest in
Allele
actin-based cell projection | oogenesis, with AbiΔ20, Scer\GAL4da.PU
actin-based cell projection | oogenesis, with AbiΔWIRS.UAS, Scer\GAL4da.PU
actin-based cell projection | oogenesis | somatic clone
actin cytoskeleton, with AbiUASp.AW
actin cytoskeleton, with AbiΔ20
actin filament bundle | oogenesis | oogenesis, with AbiΔ20, Scer\GAL4da.PU
actin filament bundle | oogenesis | oogenesis, with AbiΔWIRS.UAS, Scer\GAL4da.PU
actin filament bundle | oogenesis | somatic clone
centripetally migrating follicle cell | somatic clone
chaeta, with Scer\GAL4sca-537.4
chaeta & mesothoracic tergum | ectopic, with Scer\GAL4sca-537.4
dorsocentral bristle, with Scer\GAL4sca-537.4
egg, with Scer\GAL4da.PU
egg | maternal effect, with AbiΔ20, Scer\GAL4da.PU
egg | maternal effect, with AbiΔWIRS.UAS, Scer\GAL4da.PU
egg | maternal effect, with Scer\GAL4GR1
egg chamber, with AbiUASp.AW, Scer\GAL4da.PU
egg chamber, with AbiΔ20, Scer\GAL4da.PU
egg chamber, with AbiΔWIRS.UAS, Scer\GAL4da.PU
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage (with Df(3R)su(Hw)7)
filamentous actin, with AbiUAS.cSa
filamentous actin, with AbiUASp.ΔEna, Scer\GAL4da.PU
filamentous actin, with AbiΔ20
filamentous actin, with AbiΔ20, Scer\GAL4da.PU
filamentous actin | ectopic, with Scer\GAL4en-e16E
filopodium | oogenesis | somatic clone
follicle cell, with AbiΔ20, Scer\GAL4da.PU
follicle cell, with AbiΔWIRS.UAS, Scer\GAL4da.PU
intersegmental nerve branch ISNb of A1-7 | embryonic stage
lamina | third instar larval stage
longitudinal connective (with AbiKO)
longitudinal connective (with AbiP2)
longitudinal connective (with Df(3R)JY19)
longitudinal connective | maternal effect, with Df(3R)JY19/AbiP1
longitudinal connective | maternal effect (with Df(3R)JY19), with AbiP2
macrophage
medulla | third instar larval stage
microtubule | third instar larval stage (with Df(3R)su(Hw)7)
NMJ bouton | third instar larval stage (with Df(3R)su(Hw)7)
notopleural bristle | supernumerary, with Scer\GAL4sca-537.4
nurse cell, with AbiUAS.cSa
nurse cell, with AbiUASp.AW
nurse cell, with AbiUASp.ΔEna, Scer\GAL4da.PU
nurse cell, with AbiΔ20
nurse cell, with AbiΔ20, Scer\GAL4da.PU
outer photoreceptor cell | third instar larval stage
photoreceptor
photoreceptor cell R2 | third instar larval stage
photoreceptor cell R3 | third instar larval stage
photoreceptor cell R4 | third instar larval stage
photoreceptor cell R5 | third instar larval stage
presumptive embryonic/larval nervous system | maternal effect
scutellar bristle, with Scer\GAL4sca-537.4
sensory mother cell, with Scer\GAL4sca-537.4
sensory mother cell | supernumerary, with Scer\GAL4sca-537.4
tract | somatic clone | third instar larval stage
tract | third instar larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABI2
15 of 15
Yes
Yes
Hsap\ABI1
12 of 15
No
Yes
Hsap\ABI3
5 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abi2
14 of 15
Yes
Yes
Mmus\Abi1
12 of 15
No
Yes
Mmus\Abi3
4 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Abi1
10 of 13
Yes
Yes
Rnor\Abi2
5 of 13
No
Yes
Rnor\Abi3
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\abi1
8 of 12
Yes
Yes
Xtro\abi2
7 of 12
No
Yes
Danio rerio (Zebrafish) (7)
Drer\abi2a
14 of 15
Yes
Yes
Drer\abi2b
12 of 15
No
Yes
Drer\abi1a
10 of 15
No
Yes
Drer\abi3a
6 of 15
No
Yes
Drer\abi1b
5 of 15
No
Yes
Drer\abi3b
4 of 15
No
Yes
Drer\si:ch211-57b15.2
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\abi-1
12 of 15
Yes
Yes
Cele\mlk-1
1 of 15
No
No
Cele\nck-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\ABIL2
2 of 9
Yes
Yes
Atha\ABIL3
2 of 9
Yes
Yes
Atha\ABIL1
1 of 9
No
Yes
Atha\ABIL4
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919082Y )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Abi
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012513
Drosophila simulans
Dsim\GD20455
Drosophila sechellia
Dsec\GM25884
Drosophila erecta
Dere\GG21491
Drosophila yakuba
Dyak\GE10059
Drosophila ananassae
Dana\GF18788
Drosophila pseudoobscura pseudoobscura
Dpse\GA22007
Drosophila persimilis
Dper\GL23309
Drosophila willistoni
Dwil\GK10907
Drosophila virilis
Dvir\GJ22620
Drosophila mojavensis
Dmoj\GI24554
Drosophila grimshawi
Dgri\GH19698
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915061M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020316
Glossina morsitans
Tsetse fly
Gmor\GMOY008349
Mayetiola destructor
Hessian fly
Mdes\Mdes000647
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014130
Anopheles darlingi
American malaria mosquito
Adar\ADAC002629
Anopheles gambiae
Malaria mosquito
Agam\AGAP001046
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006389
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018548
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0721 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012500
Danaus plexippus
Monarch butterfly
Dple\DPOGS201238-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003204
Heliconius melpomene
Postman butterfly
Hmel\HMEL002771
Apis florea
Little honeybee
Aflo\3591392708
Apis mellifera
Western honey bee
Amel\Abi
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16633
Bombus terrestris
Buff-tailed bumblebee
Bter\15204901
Linepithema humile
Argentine ant
Lhum\LH17230
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00146b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG033463
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019117
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07699
Tribolium castaneum
Red flour beetle
Tcas\TC000412
Pediculus humanus
Human body louse
Phum\PHUM354390
Rhodnius prolixus
Kissing bug
Rpro\RPRC009616
Cimex lectularius
Bed bug
Clec\CLEC004137
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006331
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16022
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06X7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW002934
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69380.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11460
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308744
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AN8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abi2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abi1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abi1L_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012655
Gallus gallus
Domestic chicken
Ggal\ABI1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008714
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001287
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABI2; abl interactor 2
    15 of 15
    606442
        ABI1; abl interactor 1
        12 of 15
        603050
            ABI3; ABI family member 3
            5 of 15
            606363
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                RNA-RNA
                Physical Interaction
                Assay
                References
                Abi - mir-252
                luminiscence technology, phenotype-based detection assay, western blot
                (Lim et al., 2018)
                protein-protein
                Physical Interaction
                Assay
                References
                Abi - Abl
                enzymatic study, western blot, inferred by author, pull down
                (Lin et al., 2004, Juang and Hoffmann, 1999)
                Abi - Cdc42
                pull down, western blot
                (Fricke et al., 2009)
                Abi - Cdk1
                pull down, western blot, anti tag western blot, two hybrid
                (Lin et al., 2004)
                Abi - Cip4
                anti bait coimmunoprecipitation, western blot, two hybrid
                (Fricke et al., 2009)
                Abi - Egfr
                anti bait coimmunoprecipitation, western blot
                (Stephan et al., 2008)
                Abi - HSPC300
                pull down, molecular sieving, molecular weight estimation by staining
                (Chen et al., 2014, Ismail et al., 2009)
                Abi - Hem
                two hybrid, pull down, western blot, molecular sieving
                (Kim et al., 2019, Stephan et al., 2011, Bogdan et al., 2005, Bogdan and Klambt, 2003)
                Abi - Hexo2
                anti tag coimmunoprecipitation, western blot
                (White-Grindley et al., 2014)
                Abi - Lar
                pull down, western blot
                (Squarr et al., 2016)
                Abi - Ptp61F
                pull down, anti tag western blot
                (Huang et al., 2007)
                Abi - SCAR
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, two hybrid, molecular sieving, pull down, bimolecular fluorescence complementation, fluorescence microscopy
                (Kim et al., 2019, Chen et al., 2014, Stephan et al., 2011, Gohl et al., 2010, Fricke et al., 2009, Bogdan et al., 2005)
                Abi - Sra-1
                anti bait coimmunoprecipitation, peptide massfingerprinting
                (Gautier et al., 2011)
                Abi - WASp
                pull down, western blot, molecular sieving, two hybrid, anti bait coimmunoprecipitation
                (Kim et al., 2019, Stephan et al., 2011, Bogdan et al., 2005, Bogdan and Klambt, 2003)
                Abi - ena
                pull down, anti tag western blot, western blot, far western blotting, peptide array
                (Chen et al., 2014)
                Abi - kug
                pull down, molecular weight estimation by staining
                (Squarr et al., 2016)
                Abi - orb2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (White-Grindley et al., 2014)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Abi
                suppressible
                Abl
                (Lin et al., 2009)
                Abi
                suppressible
                SCAR
                (Stephan et al., 2011)
                Abi
                enhanceable
                SCAR
                (Kannan et al., 2017)
                Abi
                suppressible
                WASp
                (Bogdan et al., 2005)
                Abi
                suppressible
                wit
                (Kim et al., 2019)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Abl
                suppressible
                Abi
                (Kim et al., 2019, Lin et al., 2009)
                Lar
                enhanceable
                Abi
                (Squarr et al., 2016)
                Rac1
                suppressible
                Abi
                (Kim et al., 2019)
                SCAR
                enhanceable
                Abi
                (Kannan et al., 2017)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map

                3-54

                Cytogenetic map
                88A9-88A9
                Sequence location
                3R:14,119,262..14,122,420 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                88A9-88A9
                Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                88A-88B
                (determined by in situ hybridisation)
                (Gangadharan and Tear, 1999)
                Experimentally Determined Recombination Data
                Location

                3-54

                (FlyBase, 2016)

                3-52.7

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (8)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (94)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  monoclonal

                  (Kim et al., 2019)

                  polyclonal

                  (Gautier et al., 2011, Stephan et al., 2011, Georgiou and Baum, 2010)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Abi CG9749

                  (Zheng, 1999.11)
                  Source for database merge of
                  Additional comments
                  Other Comments

                  S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                  (Stroschein-Stevenson et al., 2006)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                  (Rogers et al., 2003)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 56 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (9)
                  Reported As
                  Symbol Synonym
                  Abi
                  (Gao et al., 2019, Kim et al., 2019, Lim et al., 2018, Barlan et al., 2017, Transgenic RNAi Project members, 2017-, Squarr et al., 2016, Chen et al., 2014, Chen et al., 2014, Huelsmann, 2014.12.18, Huelsmann, 2014.12.18, Valanne, 2014, White-Grindley et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Reed et al., 2012, Rohn et al., 2011, Ulvila et al., 2011, Zhu and Bhat, 2011, Zhu and Bhat, 2011, D'Ambrosio and Vale, 2010, Georgiou and Baum, 2010, Gohl et al., 2010, Hilger et al., 2009, Elwell et al., 2008, Stephan et al., 2008, Chen et al., 2007, Huang et al., 2007, Huang et al., 2007, Jani and Schock, 2007, Kondylis et al., 2007, Qurashi et al., 2007, Stroschein-Stevenson et al., 2006, Bogdan et al., 2005, Rogers et al., 2003)
                  Abi-1
                  (Tepass et al., 2002)
                  Ablphilin
                  (Gangadharan, 1999.9.16, Gangadharan and Tear, 1999)
                  CG9749
                  (Çiçek et al., 2016, White-Grindley et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Rogers et al., 2003, Ramet et al., 2002)
                  abi
                  (Crest et al., 2017, Kannan et al., 2017, Hamp et al., 2016, Gupta et al., 2014, Kondylis et al., 2011, Stephan et al., 2011, Fricke et al., 2009, Lin et al., 2009)
                  dAbi
                  (Chia et al., 2014, Wang et al., 2010, Ismail et al., 2009, Lin et al., 2004, Wahlstrom et al., 2001, Juang and Hoffmann, 1999)
                  Name Synonyms
                  Abelson Interacting Protein
                  (Chang et al., 2008, Juang et al., 1997)
                  Abelson interacting protein
                  (Gupta et al., 2014, Wang et al., 2010, Lin et al., 2009)
                  Abelson interactor
                  (Stephan et al., 2011, Gohl et al., 2010, Stephan et al., 2008)
                  Secondary FlyBase IDs
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (103)