FlyBase Gene Report: Dmel\Abi

General Information

Symbol

Dmel\Abi

Species

D. melanogaster

Name

Abelson interacting protein

Annotation Symbol

CG9749

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020510

Gene Model Status

Stock Availability

8 publicly available

Gene Snapshot

Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis. [Date last reviewed: 2019-09-26]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dAbi, Abelson interactor, Ablphilin

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:14,119,262..14,122,420 [-]

Recombination map

3-54

RefSeq locus

NT_033777 REGION:14119262..14122420

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (34 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cadherin binding

inferred from physical interaction with UniProtKB:Q9VW71

(Squarr et al., 2016)

enables protein binding

inferred from physical interaction with UniProtKB:B1Q236,UniProtKB:P55162,UniProtKB:Q8MLQ0,UniProtKB:Q9VF87,UniProtKB:Q9VKM2

(assigned by UniProt )

(Chia et al., 2014)

inferred from physical interaction with FLYBASE:Abl; FB:FBgn0000017

(Juang and Hoffmann, 1999)

inferred from physical interaction with FLYBASE:Ptp61F; FB:FBgn0267487

(Huang et al., 2007)

inferred from physical interaction with FLYBASE:ena; FB:FBgn0000578

(Chen et al., 2014)

inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771

(Bogdan and Klambt, 2003)

inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273

(Bogdan and Klambt, 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables SH3 domain binding

inferred from biological aspect of ancestor with PANTHER:PTN000048906

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (24 terms)

Terms Based on Experimental Evidence (23 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from mutant phenotype

(Lin et al., 2009, Bogdan et al., 2005)

involved_in axon extension involved in axon guidance

inferred from mutant phenotype

(Stephan et al., 2011)

involved_in cell adhesion mediated by integrin

inferred from mutant phenotype

(Gohl et al., 2010)

involved_in cell adhesion

inferred from mutant phenotype

(Jani and Schock, 2007)

involved_in cell morphogenesis

inferred from mutant phenotype

(D'Ambrosio and Vale, 2010)

involved_in cell projection assembly

inferred from mutant phenotype

(Kunda et al., 2003)

involved_in central nervous system neuron axonogenesis

inferred from mutant phenotype

(Lin et al., 2009)

involved_in centripetally migrating follicle cell migration

inferred from mutant phenotype

(Squarr et al., 2016)

involved_in chaeta development

inferred from mutant phenotype

(Stephan et al., 2008, Bogdan et al., 2005)

involved_in cortical actin cytoskeleton organization

inferred from mutant phenotype

(Kunda et al., 2003)

involved_in establishment of planar polarity of follicular epithelium

inferred from mutant phenotype

(Squarr et al., 2016)

involved_in lamellipodium assembly

inferred from mutant phenotype

(Huang et al., 2007)

involved_in muscle attachment

inferred from mutant phenotype

(Jani and Schock, 2007)

involved_in neuromuscular junction development

inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017

(Lin et al., 2009)

involved_in oogenesis

inferred from mutant phenotype

(Chen et al., 2014, Chen et al., 2014)

involved_in photoreceptor cell axon guidance

inferred from mutant phenotype

(Chen et al., 2014)

involved_in positive regulation of cytoskeleton organization

inferred from mutant phenotype

(Chen et al., 2014)

involved_in positive regulation of filopodium assembly

inferred from mutant phenotype

(Squarr et al., 2016)

involved_in positive regulation of G2/M transition of mitotic cell cycle

inferred from mutant phenotype

(Lim et al., 2018)

involved_in positive regulation of protein kinase activity

inferred from direct assay

(Juang and Hoffmann, 1999)

involved_in positive regulation of stress fiber assembly

inferred from mutant phenotype

(Squarr et al., 2016)

involved_in regulation of actin cytoskeleton organization

inferred from mutant phenotype

(Chen et al., 2014)

involved_in regulation of cell shape

inferred from mutant phenotype

(Kunda et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in actin polymerization or depolymerization

inferred from electronic annotation with InterPro:IPR036993

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

located_in actin-based cell projection

inferred from direct assay

(Squarr et al., 2016)

located_in basal cortex

inferred from direct assay

(Squarr et al., 2016)

located_in basal part of cell

inferred from direct assay

(Gohl et al., 2010)

located_in lamellipodium membrane

inferred from direct assay

(Huang et al., 2007)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Huang et al., 2007)

part_of protein-containing complex

inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273

(Stephan et al., 2011)

part_of SCAR complex

inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771, FLYBASE:SCAR; FB:FBgn0041781

(Stephan et al., 2011)

inferred from direct assay

(Chen et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

WAVE REGULATORY COMPLEX

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

WAVE REGULATORY COMPLEX -: The WAVE Regulatory Complex (WRC) is a multi-subunit complex that controls actin cytoskeletal dynamics. WRC activates the Arp2/3-mediated actin nucleation. WRC contains the nucleation-promoting factor SCAR, a member of the WASP family. (Adapted from FBrf0208042 and FBrf0224564).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

6

Number of Unique Polypeptides

3

Please see the JBrowse view of Dmel\Abi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0082910

2379

473

FBtr0112896

2373

473

FBtr0307076

2291

472

FBtr0307077

2391

477

FBtr0337096

2376

472

FBtr0337097

2294

473

Additional Transcript Data and Comments

Reported size (kB)

1.7 (longest cDNA)

(Juang and Hoffmann, 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0082371

51.9

473

6.93

FBpp0111809

51.9

473

6.93

FBpp0297919

51.9

472

6.93

FBpp0297920

52.4

477

7.09

FBpp0308012

51.9

472

6.93

FBpp0308013

51.9

473

6.93

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

473 aa isoforms: Abi-PA, Abi-PB, Abi-PF

472 aa isoforms: Abi-PC, Abi-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

473 (aa); 52 (kD observed)

(Juang and Hoffmann, 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Abi using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

eye photoreceptor cell

• axon

(Stephan et al., 2011)

(Stephan et al., 2011)

(Stephan et al., 2011)

embryonic stage 17

(Lin et al., 2009)

longitudinal connective

(Lin et al., 2009)

(Lin et al., 2009)

third instar larval stage

ventral nerve cord

(Lin et al., 2009)

embryonic/larval brain

(Lin et al., 2009)

embryonic/larval optic lobe

(Lin et al., 2009)

embryonic/larval optic stalk

(Lin et al., 2009)

photoreceptor cell

(Lin et al., 2009)

synaptic neuropil

(Lin et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval brain

(Stephan et al., 2011)

Additional Descriptive Data

Abi is expressed in the brain and ventral nerve cord of the embryonic CNS, specifically in the commissures and longitudinal connectives. There is also some staining along the midline. In third instar larvae expression is observed in several regions of the brain including the neuropil, in axon fascicles of the ventral nerve cord, in photoreceptor cells in the eye disc, and in photoreceptor axons projecting through the optic stalk into the optic lobe.

(Lin et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in actin-based cell projection

inferred from direct assay

(Squarr et al., 2016)

located_in basal cortex

inferred from direct assay

(Squarr et al., 2016)

located_in basal part of cell

inferred from direct assay

(Gohl et al., 2010)

located_in lamellipodium membrane

inferred from direct assay

(Huang et al., 2007)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Huang et al., 2007)

part_of protein-containing complex

inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273

(Stephan et al., 2011)

part_of SCAR complex

inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771, FLYBASE:SCAR; FB:FBgn0041781

(Stephan et al., 2011)

inferred from direct assay

(Chen et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Abi in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Abi

View exonic expression by tissue for Dmel\Abi

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020510

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020510

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9749-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9749

Flygut - An atlas of the Drosophila adult midgut

FBgn0020510

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 35 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Abi

Transgenic constructs containing regulatory region of Abi

Deletions and Duplications ( 1 )

Disrupted in

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Abi^KO

lethal - all die before end of embryonic stage | germline clone | maternal effect | recessive

Abi^unspecified

lethal - all die before end of P-stage

Abi^Δ20

lethal - all die before end of pupal stage (with Abi^KO)

Abi^P2

lethal - all die before end of pupal stage (with Abi^P2)

Abi^KO

lethal - all die before end of pupal stage (with Df(3R)JY19)

lethal - all die during P-stage (with Df(3R)su(Hw)7)

Abi⁵

partially lethal - majority die, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^elav-C155

Abi^UAS.Tag:HA

partially lethal - majority die, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^how-24B

Abi^UAS.Tag:HA

partially lethal - majority die (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^elav-C155

Abi⁵

partially lethal - majority die (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^how-24B

Abi⁵

partially lethal - majority live, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^elav-C155, Scer\GAL4^how-24B

Abi^UAS.Tag:HA

partially lethal - majority live (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^elav-C155, Scer\GAL4^how-24B

Abi⁵

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Abi^GD14302

viable, with Scer\GAL4^pnr-MD237

Abi^GD14302

viable, with Scer\GAL4^tin.CΔ4

Abi^GD14302

Sterility

Allele

female fertile, with Scer\GAL4^da.PU

Abi^UASp.ΔEna

female semi-sterile, with Abi^UASp.AW, Scer\GAL4^da.PU

Abi^Δ20

female semi-sterile, with Abi^UASp.cCa, Scer\GAL4^da.PU

Abi^Δ20

female semi-sterile, with Abi^Δ20, Scer\GAL4^da.PU

female sterile, with Abi^UAS.cSa, Scer\GAL4^da.PU

Abi^Δ20

female sterile, with Abi^UASp.ΔEna, Scer\GAL4^da.PU

Abi^Δ20

female sterile, with Abi^Δ20, Scer\GAL4^da.PU

Other Phenotypes

Allele

cell migration defective, with Abi^Δ20, Scer\GAL4^da.PU

Abi^ΔWIRS.UAS

cell migration defective, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

cell polarity defective, with Abi^Δ20, Scer\GAL4^da.PU

Abi^ΔWIRS.UAS

cell polarity defective, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

flight defective, with Scer\GAL4^Mef2.PR

Abi^GD14302

majority die during P-stage, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^elav-C155

Abi^UAS.Tag:HA

majority die during P-stage, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^how-24B

Abi^UAS.Tag:HA

majority die during P-stage (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^elav-C155

Abi⁵

majority die during P-stage (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^how-24B

Abi⁵

neuroanatomy defective

Abi^Δ20

neuroanatomy defective | embryonic stage (with Abi^KO)

Abi^P2

neuroanatomy defective | embryonic stage (with Abi^P2)

Abi^KO

neuroanatomy defective | embryonic stage | maternal effect, with Df(3R)JY19/Abi^P1

Abi^P2

neuroanatomy defective | embryonic stage | maternal effect (with Df(3R)JY19), with Abi^P2

Abi^P1

neuroanatomy defective | recessive | third instar larval stage

Abi^Δ20

neuroanatomy defective | third instar larval stage

neuroanatomy defective | third instar larval stage (with Df(3R)su(Hw)7)

Abi⁵

neurophysiology defective | third instar larval stage, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^Abi.PK

Abi^UAS.Tag:HA

neurophysiology defective | third instar larval stage (with Df(3R)su(Hw)7)

Abi⁵

neurophysiology defective | third instar larval stage (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^Abi.PK

Abi⁵

some die during embryonic stage | maternal effect | recessive

Abi^unspecified

some die during P-stage

Abi^Δ20

some die during P-stage, with Abi⁵/Df(3R)su(Hw)7, Scer\GAL4^elav-C155, Scer\GAL4^how-24B

Abi^UAS.Tag:HA

some die during P-stage (with Df(3R)su(Hw)7), with Abi^UAS.Tag:HA, Scer\GAL4^elav-C155, Scer\GAL4^how-24B

Abi⁵

some die during pupal stage (with Abi^KO)

Abi^P2

some die during pupal stage (with Abi^P2)

Abi^KO

some die during pupal stage (with Df(3R)JY19)

uncoordinated (with Df(3R)su(Hw)7)

Abi⁵

visible, with Scer\GAL4^sca-537.4

Phenotype manifest in

Allele

actin-based cell projection | oogenesis | oogenesis, with Abi^Δ20, Scer\GAL4^da.PU

Abi^ΔWIRS.UAS

actin-based cell projection | oogenesis | oogenesis, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

actin-based cell projection | oogenesis | oogenesis | somatic clone

Abi^Δ20

actin cytoskeleton, with Abi^UASp.AW

Abi^Δ20

actin cytoskeleton, with Abi^Δ20

Abi^UASp.AW

actin filament bundle | oogenesis | oogenesis, with Abi^Δ20, Scer\GAL4^da.PU

Abi^ΔWIRS.UAS

actin filament bundle | oogenesis | oogenesis, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

actin filament bundle | oogenesis | somatic clone

Abi^Δ20

centripetal follicle cell | somatic clone

Abi^Δ20

chaeta, with Scer\GAL4^sca-537.4

Abi^dsRNA.UAS

chaeta & mesothoracic tergum | ectopic, with Scer\GAL4^sca-537.4

Abi^{UAS.Tag:Myr(Src64B)}

dorsocentral bristle, with Scer\GAL4^sca-537.4

Abi^dsRNA.UAS

egg, with Scer\GAL4^da.PU

Abi^UAS.ΔEna

egg | maternal effect, with Abi^Δ20, Scer\GAL4^da.PU

Abi^ΔWIRS.UAS

egg | maternal effect, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

egg | maternal effect, with Scer\GAL4^GR1

Abi^HMS01597

egg chamber, with Abi^UASp.AW, Scer\GAL4^da.PU

Abi^Δ20

egg chamber, with Abi^Δ20, Scer\GAL4^da.PU

egg chamber, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

embryonic/larval neuromuscular junction | third instar larval stage

embryonic/larval neuromuscular junction | third instar larval stage (with Df(3R)su(Hw)7)

Abi⁵

filamentous actin, with Abi^UAS.cSa

Abi^Δ20

filamentous actin, with Abi^UASp.ΔEna, Scer\GAL4^da.PU

Abi^Δ20

filamentous actin, with Abi^Δ20

Abi^UAS.cSa

filamentous actin, with Abi^Δ20, Scer\GAL4^da.PU

Abi^UASp.ΔEna

filamentous actin | ectopic, with Scer\GAL4^en-e16E

Abi^{UAS.Tag:Myr(Src64B)}

filopodium | oogenesis | somatic clone

Abi^Δ20

follicle cell, with Abi^Δ20, Scer\GAL4^da.PU

Abi^ΔWIRS.UAS

follicle cell, with Abi^ΔWIRS.UAS, Scer\GAL4^da.PU

Abi^Δ20

intersegmental nerve branch ISNb of A1-7 | embryonic stage

Abi^KO

lamina | third instar larval stage

Abi^Δ20

longitudinal connective (with Abi^KO)

Abi^P2

longitudinal connective (with Abi^P2)

Abi^KO

longitudinal connective (with Df(3R)JY19)

Abi^KO

longitudinal connective | maternal effect, with Df(3R)JY19/Abi^P1

Abi^P2

longitudinal connective | maternal effect (with Df(3R)JY19), with Abi^P2

Abi^P1

Abi^Δ20

medulla | third instar larval stage

Abi^Δ20

microtubule | third instar larval stage (with Df(3R)su(Hw)7)

Abi⁵

NMJ bouton | third instar larval stage (with Df(3R)su(Hw)7)

Abi⁵

notopleural bristle | supernumerary, with Scer\GAL4^sca-537.4

Abi^{UAS.Tag:Myr(Src64B)}

nurse cell, with Abi^UAS.cSa

Abi^Δ20

nurse cell, with Abi^UASp.AW

Abi^Δ20

nurse cell, with Abi^UASp.ΔEna, Scer\GAL4^da.PU

Abi^Δ20

nurse cell, with Abi^Δ20

nurse cell, with Abi^Δ20, Scer\GAL4^da.PU

Abi^UASp.ΔEna

outer photoreceptor cell | third instar larval stage

Abi^Δ20

Abi^Δ20

photoreceptor cell R2 | third instar larval stage

Abi^Δ20

photoreceptor cell R3 | third instar larval stage

Abi^Δ20

photoreceptor cell R4 | third instar larval stage

Abi^Δ20

photoreceptor cell R5 | third instar larval stage

Abi^Δ20

presumptive embryonic/larval nervous system | maternal effect

Abi^unspecified

scutellar bristle, with Scer\GAL4^sca-537.4

Abi^dsRNA.UAS

sensory mother cell, with Scer\GAL4^sca-537.4

Abi^dsRNA.UAS

sensory mother cell | supernumerary, with Scer\GAL4^sca-537.4

Abi^{UAS.Tag:Myr(Src64B)}

tract | somatic clone | third instar larval stage

Abi^Δ20

tract | third instar larval stage

Abi^Δ20

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

12 of 15

No

Yes

5 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

12 of 15

Yes

Yes

5 of 15

No

Yes

Rattus norvegicus (Norway rat) (3)

9 of 13

Yes

Yes

5 of 13

No

Yes

5 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (2)

8 of 12

Yes

Yes

7 of 12

No

Yes

Danio rerio (Zebrafish) (6)

13 of 15

Yes

Yes

11 of 15

No

Yes

9 of 15

No

Yes

6 of 15

No

Yes

5 of 15

No

Yes

4 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

12 of 15

Yes

Yes

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (4)

1 of 9

Yes

Yes

1 of 9

Yes

Yes

1 of 9

Yes

Yes

1 of 9

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919082Y )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00012513

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915061M )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY008349

Mayetiola destructor

Hessian fly

Mdes\Mdes000647

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014130

Anopheles darlingi

American malaria mosquito

Adar\ADAC002629

Anopheles gambiae

Malaria mosquito

Agam\AGAP001046

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006389

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018548

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0721 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012500

Danaus plexippus

Monarch butterfly

Dple\DPOGS201238-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL003204

Heliconius melpomene

Postman butterfly

Hmel\HMEL002771

Apis florea

Little honeybee

Aflo\3591392708

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00146b

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG033463

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG019117

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM354390

Rhodnius prolixus

Kissing bug

Rpro\RPRC009616

Cimex lectularius

Bed bug

Clec\CLEC004137

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006331

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16022

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06X7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW002934

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69380.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g11460

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308744

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AN8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Abi1L_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012655

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008714

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001287

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ABI2; abl interactor 2

14 of 15

ABI1; abl interactor 1

12 of 15

ABI3; ABI family member 3

5 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

phenotype-based detection assay, western blot, luminiscence technology

(Lim et al., 2018)

protein-protein

Physical Interaction

Assay

References

pull down, western blot, enzymatic study, inferred by author

(Lin et al., 2004, Juang and Hoffmann, 1999)

pull down, western blot

(Fricke et al., 2009)

two hybrid, pull down, western blot, anti tag western blot

(Lin et al., 2004)

anti bait coimmunoprecipitation, western blot, two hybrid

(Fricke et al., 2009)

anti bait coimmunoprecipitation, peptide massfingerprinting

(Gautier et al., 2011)

anti bait coimmunoprecipitation, western blot

(Stephan et al., 2008)

pull down, molecular sieving, molecular weight estimation by staining

(Chen et al., 2014, Ismail et al., 2009)

pull down, western blot, two hybrid, molecular sieving

(Kim et al., 2019, Stephan et al., 2011, Bogdan et al., 2005, Bogdan and Klambt, 2003)

anti tag coimmunoprecipitation, western blot

(White-Grindley et al., 2014)

pull down, western blot

(Squarr et al., 2016)

pull down, anti tag western blot

(Huang et al., 2007)

anti tag coimmunoprecipitation, western blot, pull down, two hybrid, molecular sieving, bimolecular fluorescence complementation, fluorescence microscopy, anti bait coimmunoprecipitation

(Kim et al., 2019, Chen et al., 2014, Stephan et al., 2011, Gohl et al., 2010, Fricke et al., 2009, Bogdan et al., 2005)

pull down, western blot, anti bait coimmunoprecipitation, two hybrid, molecular sieving

(Kim et al., 2019, Stephan et al., 2011, Bogdan et al., 2005, Bogdan and Klambt, 2003)

pull down, anti tag western blot, far western blotting, peptide array, western blot

(Chen et al., 2014)

pull down, molecular weight estimation by staining

(Squarr et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(White-Grindley et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lin et al., 2009)

suppressible

(Stephan et al., 2011)

enhanceable

(Kannan et al., 2017)

suppressible

(Bogdan et al., 2005)

suppressible

(Kim et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Kim et al., 2019, Lin et al., 2009)

enhanceable

(Squarr et al., 2016)

suppressible

(Kim et al., 2019)

enhanceable

(Kannan et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66795

DroID - A comprehensive database of gene and protein interactions.

FBgn0020510

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41718

MIST (protein-protein) - An integrated Molecular Interaction Database

Abi

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-54

Cytogenetic map

Sequence location

3R:14,119,262..14,122,420 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88A9-88A9

Limits computationally determined from genome sequence between P{PZ}flfl⁰¹⁹⁴⁹ and P{lacW}trx^j14A6&P{PZ}trx⁰⁰³⁴⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

88A-88B

(determined by in situ hybridisation)

(Gangadharan and Tear, 1999)

Experimentally Determined Recombination Data

Location

3-54

(FlyBase, 2016)

3-52.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

51455

y¹ v¹; P{TRiP.HMC03190}attP40

58730

y¹ w^*; M{UASp-mCherry.Abi}ZH-51D

58729

w^*; P{Ubi-mCherry.Abi}3/TM6B, Tb¹

23107

y¹ w^67c23; P{EPgy2}Abi^EY20423

83974

y¹ sc^* v¹ sev²¹; P{TKO.GS04060}attP40

36707

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01597}attP2

v100714

P{KK108071}VIE-260B

v36142

w¹¹¹⁸; P{GD14302}v36142/TM3

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (94)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD37010

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020510

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020510

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41718

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Kim et al., 2019)

polyclonal

(Gautier et al., 2011, Stephan et al., 2011, Georgiou and Baum, 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Abi CG9749

(Zheng, 1999.11)

Source for database merge of

Additional comments

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41718

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020510

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020510

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9749

Flygut - An atlas of the Drosophila adult midgut

FBgn0020510

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41718

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000412

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9749

modMine - A data warehouse for the modENCODE project

FBgn0020510

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9Y0S9

Linkouts

BioGRID - A database of protein and genetic interactions.

66795

DroID - A comprehensive database of gene and protein interactions.

FBgn0020510

DRSC - Results frm RNAi screens

FBgn0020510

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020510

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9749-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020510

FlyMine - An integrated database for Drosophila genomics

FBgn0020510

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41718

MIST (protein-protein) - An integrated Molecular Interaction Database

Abi

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Abi-1

(Tepass et al., 2002)

Ablphilin

(Gangadharan, 1999.9.16, Gangadharan and Tear, 1999)

CG9749

(Çiçek et al., 2016, White-Grindley et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Rogers et al., 2003, Ramet et al., 2002)

abi

(Santa-Cruz Mateos et al., 2020, Crest et al., 2017, Kannan et al., 2017, Hamp et al., 2016, Gupta et al., 2014, Kondylis et al., 2011, Stephan et al., 2011, Fricke et al., 2009, Lin et al., 2009)

dAbi

(Chia et al., 2014, Wang et al., 2010, Ismail et al., 2009, Lin et al., 2004, Wahlstrom et al., 2001, Juang and Hoffmann, 1999)

Name Synonyms

Abelson Interacting Protein

(Chang et al., 2008, Juang et al., 1997)

Abelson interacting protein

(Gupta et al., 2014, Wang et al., 2010, Lin et al., 2009)

Abelson interactor

(Stephan et al., 2011, Gohl et al., 2010, Stephan et al., 2008)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (106)