A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Abi

General Information
SymbolDmel\AbiSpeciesD. melanogaster
NameAbelson Interacting ProteinAnnotation symbolCG9749
Feature typeprotein_coding_geneFlyBase IDFBgn0020510
Created / Updated2003-12-01/2007-03-20
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map88A9-88A9Sequence location3R:9,944,982..9,948,142 [-]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
The gene Abelson Interacting Protein is referred to in FlyBase by the symbol Abi (CG9749, FBgn0020510). It has the cytological map location 88A9. Its sequence location is 3R:9944982..9948142. Its molecular function is described as: signal transducer activity; protein binding. It is involved in the biological processes: positive regulation of protein kinase activity; cell projection biogenesis; cortical actin cytoskeleton organization and biogenesis; regulation of cell shape; phagocytosis, engulfment; cell adhesion; muscle attachment; lamellipodium biogenesis. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
88A9-88A9  
Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
88A-88B
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: Abi- twf+ 140up-
hide Gene Model & Products
Please see the GBrowse view of Dmel\Abi for information on other features
detailed view FBtr0112896 FBtr0082910 FBtr0082891 FBtr0082909 FBpp0082371 FBpp0111809 FBpp0082352 FBti0075450 FBti0011782 FBti0044920
Comments on Gene Model
EST data support existence of multiple transcripts due to variable use of 5' exons
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0082910
  2381
  473
FBtr0112896
  2375
  473
Additional Transcript Data & Comments
Reported size (kB)
1.7 (longest cDNA)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Abi-PA  
FBpp0082371  
51.9  
473  
6.93  
Abi-PB  
FBpp0111809  
51.9  
473  
6.93  
Additional Polypeptide Data & Comments
Reported size (kD)
473 (aa); 52 (kD observed)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0112896 FBtr0082910 FBtr0082891 FBtr0082909
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of AbiClassMutagenStocksKnown lesion
        AbiEY204231 --
        hide Alleles Carried on Transgenic Constructs ( 6 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of AbiClassMutagenStocksKnown lesion
        AbiAct5C.T:Ivir\HA10 Yes
        AbiGD143021 Yes
        Abia.Act5C0 Yes
        AbidsRNA.cKa0 Yes
        AbidsRNA.cRa0 Yes
        AbiΔSH3.Act5C.T:Ivir\HA10 Yes
        hide Aneuploid Aberrations
        Useful deficiency
        Disrupted in
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        Insertions
        Type of insertions
        Name
        Expression data
        insertion of mobile activating element
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
        hide Gene Ontology: Function, Process & Cellular Component ( 13 )
        hide Molecular Function
        CV term
        References
        inferred from physical interaction with FLYBASE:Abl; FB:FBgn0000017
        inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771 AND inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
        inferred from physical interaction with FLYBASE:Ptp61F; FB:FBgn0003138
        inferred from sequence or structural similarity with EMBL:U17698
        hide Biological Process
        CV term
        References
        inferred from mutant phenotype
        inferred from mutant phenotype
        inferred from mutant phenotype
        inferred from mutant phenotype
        inferred from mutant phenotype
        inferred from mutant phenotype
        inferred from direct assay
        inferred from mutant phenotype
        hide Cellular Component
        CV term
        References
        inferred from electronic annotation with InterPro:IPR012849
        inferred from direct assay
        inferred from direct assay
        hide Sequence Ontology: Class of Gene
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Abi allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 2 )
        VDRC
        Bloomington
        hide Genomic Clones ( 2 )
        hide cDNA Clones ( 47 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: Abi CG9749
        Source for database merge of
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        RefSeq (Proteins)
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        DEDB - Drosophila exon database: splicing graphs
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        InParanoid orthologs - Eukaryotic orthologs