l(2)06736, l(2)45Ca, Protein kinase related to protein kinase N, Dpkn, 3-2
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.49
Gene model reviewed during 6.05
Interacts (via N-terminus) with Rho1 (via REM repeats), Rac1 (via REM 1 repeat) and Rac2.
Phosphorylated (By similarity). Autophosphorylated; autophosphorylation is stimulated by GTP-bound Rho/Rac GTPases.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pkn using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pkn in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG2049, CG2055 merged as CG2049 in release 3 of the genome annotation.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
Pkn is required specifically for epidermal shape changes during the morphogenetic process of dorsal closure in the developing embryo. Together with Rho1, Pkn mediates a pathway for cell shape changes in dorsal closure that is independent of the Rac GTPase-mediated Jun amino (N)-terminal kinase (JNK) cascade.
Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.