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Gene Dmel\Lcp65Ag1

General Information
Symbol	Dmel\Lcp65Ag1	Species	D. melanogaster
Name	Lcp65Ag1	Annotation symbol	CG10530
Feature type	protein_coding_gene	FlyBase ID	FBgn0020638
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	LCP8
Genomic Location
Chromosome (arm)	3L	Recombination map	3-11
Cytogenetic map	65A6-65A6	Sequence location	3L:6,127,797..6,128,374 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lcp65Ag1 is referred to in FlyBase by the symbol Dmel\Lcp65Ag1 (CG10530, FBgn0020638). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of chitin-based cuticle; structural constituent of chitin-based larval cuticle. It is reported to be involved in the biological process: larval chitin-based cuticle development. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Insect cuticle protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Lcp65Ag1. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Lcp65Ag1. Gene sequence location is 3L:6127797..6128374.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65A6-65A6   Limits computationally determined from genome sequence between P{PZ}loj04026 and P{PZ}l(3)0209402094
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65A-65A     (Charles et al., 1996)
Experimentally Determined Recombination Data
Location	3-11 (Chihara and Kimbrell, 1986)
Left of (cM)
Right of (cM)
Notes	Not separated from Lcp65Ab1 or Lcp65Ab2 in 563 progeny.   Maps within 0.18 map units of Lcp65Ab1 and Lcp65Ab2. (Chihara and Kimbrell, 1986)
Gene Model & Products
Please see the GBrowse view of Dmel\Lcp65Ag1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lcp65Ag1-RA FBtr0077058  NM_057925   517   105
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lcp65Ag1-PA   FBpp0076766   11.2   105   3.91     NP_477273   AAF50692
Additional Polypeptide Data & Comments
Reported size (kDa)	105 (aa) (Charles et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50692   AC004357   AC004767   AI256923   AI257277   AI294350   AY061536   BI168655   BI169677   BI214882   BI232179   BI236790   BI357856   BI357909   BI362894   BI482330   BI580346   BT001522   BT011478   BT030765   BT032679   BT126359   CO265493   CO302152   EC061401   EC246189   FE862760   FE862852   FE863002   GH738831   GH739324   GH739775   GH744946   GH745559   GH761557   GH764132   GH768847   GH948826   GH951476   GH954105   GH959431   GH959909   GH961677   GH961821   GH962078   GH970622   GH972873   GH980660   GH980865   U84753 AAB88071
UniProtKB/Swiss-Prot	P92201
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Charles et al., 1998) larval stage     (Charles et al., 1998) prepupal stage P4 -- pupal stage P5(i)     (Charles et al., 1998) Comment:reference states 7-13 hr APF
Additional Descriptive Data
	With a probe that recognizes Lcp65Ag1, Lcp65Ag2, and Lcp65Ag3 transcripts, expression is detected at significant levels during the synthesis of all larval cuticles. Expression is first detected in the embryo during the synthesis of the first instar larval cuticle, declines after ecdysis, and increases again during the synthesis of the cuticles for the second and third larval instars. Declines again between 12-18 hr after ecdysis to the third larval instar. Expressed transiently at 7-13 hr after pupariation, during pupal cuticle deposition. (Charles et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    10 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    19 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr    35 embryo 16-18hr    513 embryo 18-20hr    1390 embryo 20-22hr    2168 embryo 22-24hr    1098 larva L1    836 larva L2    261 larva L3 12hr old    3127 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    144 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr  (35) embryo 16-18hr  (513) embryo 18-20hr  (1390) embryo 20-22hr  (2168) embryo 22-24hr  (1098) larva L1  (836) larva L2  (261) larva L3 12hr old  (3127) larva L3 puffstage 1-2  (77) larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr  (144) white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr    35 embryo 16-18hr  (513) embryo 18-20hr  (1390) embryo 20-22hr  (2168) embryo 22-24hr  (1098) larva L1  (836) larva L2  (261) larva L3 12hr old  (3127) larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr  (144) white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr    35 embryo 16-18hr    513 embryo 18-20hr    1390 embryo 20-22hr    2168 embryo 22-24hr    1098 larva L1    836 larva L2    261 larva L3 12hr old    3127 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    144 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr    35 embryo 16-18hr    513 embryo 18-20hr    1390 embryo 20-22hr    2168 embryo 22-24hr    1098 larva L1    836 larva L2    261 larva L3 12hr old    3127 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    144 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr  (35) embryo 16-18hr  (513) embryo 18-20hr  (1390) embryo 20-22hr  (2168) embryo 22-24hr  (1098) larva L1  (836) larva L2  (261) larva L3 12hr old  (3127) larva L3 puffstage 1-2  (77) larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr  (144) white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr    35 embryo 16-18hr  (513) embryo 18-20hr  (1390) embryo 20-22hr  (2168) embryo 22-24hr  (1098) larva L1  (836) larva L2  (261) larva L3 12hr old  (3127) larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr  (144) white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    2 embryo 14-16hr    35 embryo 16-18hr    513 embryo 18-20hr    1390 embryo 20-22hr    2168 embryo 22-24hr    1098 larva L1    836 larva L2    261 larva L3 12hr old    3127 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    144 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    10 pupae 4d postWPP    2 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    368 Cadmium 50 mM 6 hrs, larvae L3    795 Cadmium 50 mM 12 hrs, larvae L3    122 Cadmium 50 mM 48 hrs, 4-day adult    600 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    139 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    380 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1188 Ethanol 10% 3 hrs, larvae L3    919 Caffeine 1.5 mg/ml 4 hrs, larvae L3    530 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    699 Rotenone 8 μg 12 hrs, larvae L3    1381 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult  (368) Cadmium 50 mM 6 hrs, larvae L3  (795) Cadmium 50 mM 12 hrs, larvae L3  (122) Cadmium 50 mM 48 hrs, 4-day adult  (600) Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3  (139) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3  (380) Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3  (1188) Ethanol 10% 3 hrs, larvae L3  (919) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (530) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3  (699) Rotenone 8 μg 12 hrs, larvae L3  (1381) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult  (368) Cadmium 50 mM 6 hrs, larvae L3  (795) Cadmium 50 mM 12 hrs, larvae L3  (122) Cadmium 50 mM 48 hrs, 4-day adult  (600) Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3  (139) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3  (380) Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3  (1188) Ethanol 10% 3 hrs, larvae L3  (919) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (530) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3  (699) Rotenone 8 μg 12 hrs, larvae L3  (1381) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    368 Cadmium 50 mM 6 hrs, larvae L3    795 Cadmium 50 mM 12 hrs, larvae L3    122 Cadmium 50 mM 48 hrs, 4-day adult    600 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    139 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    380 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1188 Ethanol 10% 3 hrs, larvae L3    919 Caffeine 1.5 mg/ml 4 hrs, larvae L3    530 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    699 Rotenone 8 μg 12 hrs, larvae L3    1381 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    368 Cadmium 50 mM 6 hrs, larvae L3    795 Cadmium 50 mM 12 hrs, larvae L3    122 Cadmium 50 mM 48 hrs, 4-day adult    600 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    139 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    380 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1188 Ethanol 10% 3 hrs, larvae L3    919 Caffeine 1.5 mg/ml 4 hrs, larvae L3    530 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    699 Rotenone 8 μg 12 hrs, larvae L3    1381 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult  (368) Cadmium 50 mM 6 hrs, larvae L3  (795) Cadmium 50 mM 12 hrs, larvae L3  (122) Cadmium 50 mM 48 hrs, 4-day adult  (600) Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3  (139) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3  (380) Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3  (1188) Ethanol 10% 3 hrs, larvae L3  (919) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (530) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3  (699) Rotenone 8 μg 12 hrs, larvae L3  (1381) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult  (368) Cadmium 50 mM 6 hrs, larvae L3  (795) Cadmium 50 mM 12 hrs, larvae L3  122 Cadmium 50 mM 48 hrs, 4-day adult  (600) Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3  139 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3  (380) Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3  (1188) Ethanol 10% 3 hrs, larvae L3  (919) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (530) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3  (699) Rotenone 8 μg 12 hrs, larvae L3  (1381) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    368 Cadmium 50 mM 6 hrs, larvae L3    795 Cadmium 50 mM 12 hrs, larvae L3    122 Cadmium 50 mM 48 hrs, 4-day adult    600 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    139 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    380 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1188 Ethanol 10% 3 hrs, larvae L3    919 Caffeine 1.5 mg/ml 4 hrs, larvae L3    530 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    699 Rotenone 8 μg 12 hrs, larvae L3    1381 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_32 mE1_20_mRNA_expression_cluster_12
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020638
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele electrophoretic variant | slow Lcp65Ag1S Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Lcp65Ag1 Class Mutagen Stocks Known lesion Lcp65Ag1S natural population 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lcp65Ag1 Class Mutagen Stocks Known lesion Lcp65Ag1GD17309 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel8101 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4872} NA P{GD17309} NA P{GD17310} NA P{GD17404} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
structural constituent of chitin-based cuticle inferred from sequence or structural similarity with InterPro:IPR000618 (Willis, 2007.1.3) inferred from sequence or structural similarity with Pfam:PF00379 (Willis, 2007.1.3) structural constituent of chitin-based larval cuticle inferred from sequence or structural similarity (Charles et al., 1997) inferred from sequence or structural similarity with EMBL:AF026266 (FlyBase, 1992-) non-traceable author statement (assigned by UniProtKB) (Charles et al., 1998)
Biological Process
CV term Evidence References
larval chitin-based cuticle development non-traceable author statement (assigned by UniProtKB) (Charles et al., 1998)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (assigned by UniProtKB) (Charles et al., 1998)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lcp65Ag1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64158 DroID - A comprehensive database of gene and protein interactions. • FBgn0020638 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38703
Orthologs
OrthoDB Orthologs (261) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6T1J7B Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6KKX13, EOG6QJQK1 Arthropod inclusive ortholog search EOG63R24R Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6T1J7B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Lcp65Ag3     Drosophila melanogaster fruit fly  Dmel\Lcp65Ag2     Drosophila melanogaster fruit fly  Dmel\Lcp65Ag1     Drosophila melanogaster fruit fly  Dmel\Lcp65Af     Drosophila simulans   Dsim\GD13150   Y Drosophila simulans   Dsim\GD13151   Y Drosophila simulans   Dsim\GD13153   Y Drosophila simulans   Dsim\GD13149   Y Drosophila sechellia   Dsec\GM13866   Y Drosophila sechellia   Dsec\GM13868   Y Drosophila erecta   Dere\GG14086   Y Drosophila erecta   Dere\GG14083   Y Drosophila ananassae   Dana\GF10925   Y Drosophila ananassae   Dana\GF10921   Y Drosophila ananassae   Dana\GF23525   Y Drosophila ananassae   Dana\GF23526   Y Drosophila ananassae   Dana\GF10918   Y Drosophila ananassae   Dana\GF10923   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA23851   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA23852   Y Drosophila persimilis   Dper\GL15517   Y Drosophila persimilis   Dper\GL15520   Y Drosophila willistoni   Dwil\GK16924   Y Drosophila willistoni   Dwil\GK16916   Y Drosophila willistoni   Dwil\GK16914   Y Drosophila willistoni   Dwil\GK16921   Y Drosophila willistoni   Dwil\GK16923   Y Drosophila virilis   Dvir\GJ12680   Y Drosophila virilis   Dvir\GJ12749   Y Drosophila virilis   Dvir\GJ12681   Y Drosophila virilis   Dvir\GJ12752   Y Drosophila mojavensis   Dmoj\GI12627   Y Drosophila mojavensis   Dmoj\GI12628   Y Drosophila grimshawi   Dgri\GH15845   Y Drosophila grimshawi   Dgri\GH15846   Y Drosophila grimshawi   Dgri\GH15650   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6KKX13, EOG6QJQK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47906 Y Apis mellifera Western honey bee  Amel\LOC724649 Y Apis mellifera Western honey bee  Amel\CPR12 Y Apis mellifera Western honey bee  Amel\GB46298 Y Apis mellifera Western honey bee  Amel\GB52161 Y Apis mellifera Western honey bee  Amel\CPR13 Y Apis mellifera Western honey bee  Amel\GB47903 Y Apis mellifera Western honey bee  Amel\GB42612 Y Apis mellifera Western honey bee  Amel\GB43670 Y Apis mellifera Western honey bee  Amel\GB46297 Y Apis mellifera Western honey bee  Amel\GB47902 Y Apis mellifera Western honey bee  Amel\GB46312 Y Apis mellifera Western honey bee  Amel\GB46299 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006503 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006859 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005393 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006863 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013411 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013416 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006864 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010389 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010007 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006867 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016022 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013414 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013417 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007522 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006861 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010008 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006862 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013413 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22753 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22751 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17027 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17029 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21414 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19798 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22756 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17028 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22755 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21415 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21416 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22752 Y Atta cephalotes Leafcutter ant  Acep\ACEP25267 Y Atta cephalotes Leafcutter ant  Acep\ACEP27437 Y Atta cephalotes Leafcutter ant  Acep\ACEP24251 Y Atta cephalotes Leafcutter ant  Acep\ACEP17449 Y Atta cephalotes Leafcutter ant  Acep\ACEP27431 Y Atta cephalotes Leafcutter ant  Acep\ACEP25266 Y Atta cephalotes Leafcutter ant  Acep\ACEP24250 Y Atta cephalotes Leafcutter ant  Acep\ACEP27444 Y Atta cephalotes Leafcutter ant  Acep\ACEP27432 Y Atta cephalotes Leafcutter ant  Acep\ACEP25277 Y Atta cephalotes Leafcutter ant  Acep\ACEP24236 Y Atta cephalotes Leafcutter ant  Acep\ACEP25265 Y Atta cephalotes Leafcutter ant  Acep\ACEP27427 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21033 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14804 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21024 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21020 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20940 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15374 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20939 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21032 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21025 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20958 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21019 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21021 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14803 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14802 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21887 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21889 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20594 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20587 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19362 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20586 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19363 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20593 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20772 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19364 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21888 Y Linepithema humile Argentine ant  Lhum\LH23807 Y Linepithema humile Argentine ant  Lhum\LH19211 Y Linepithema humile Argentine ant  Lhum\LH16388 Y Linepithema humile Argentine ant  Lhum\LH16391 Y Linepithema humile Argentine ant  Lhum\LH19218 Y Linepithema humile Argentine ant  Lhum\LH16383 Y Linepithema humile Argentine ant  Lhum\LH10870 Y Linepithema humile Argentine ant  Lhum\LH24581 Y Linepithema humile Argentine ant  Lhum\LH24582 Y Linepithema humile Argentine ant  Lhum\LH16382 Y Linepithema humile Argentine ant  Lhum\LH24583 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20785 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14690 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18423 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14691 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18425 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14673 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20784 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14688 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20800 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24199 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14682 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20794 Y Solenopsis invicta Red fire ant  Sinv\SINV25632 Y Solenopsis invicta Red fire ant  Sinv\SINV21745 Y Solenopsis invicta Red fire ant  Sinv\SINV21730 Y Solenopsis invicta Red fire ant  Sinv\SINV25026 Y Solenopsis invicta Red fire ant  Sinv\SINV16553 Y Solenopsis invicta Red fire ant  Sinv\SINV21768 Y Solenopsis invicta Red fire ant  Sinv\SINV25020 Y Solenopsis invicta Red fire ant  Sinv\SINV25023 Y Solenopsis invicta Red fire ant  Sinv\SINV16530 Y Solenopsis invicta Red fire ant  Sinv\SINV21761 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009006 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI066082 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003649 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001610 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005591 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001775 Y Bombyx mori Silkmoth  Bmor\BmorCPR23 Y Bombyx mori Silkmoth  Bmor\BmorCPR39 Y Bombyx mori Silkmoth  Bmor\BmorCPR6 Y Bombyx mori Silkmoth  Bmor\BmorCPR33 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000340 Y Bombyx mori Silkmoth  Bmor\BmorCPR26 Y Bombyx mori Silkmoth  Bmor\BmorCPR37 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007015 Y Bombyx mori Silkmoth  Bmor\BmorCPR7 Y Bombyx mori Silkmoth  Bmor\BmorCPR24 Y Bombyx mori Silkmoth  Bmor\BmorCPR4 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000341 Y Bombyx mori Silkmoth  Bmor\BmorCPR34 Y Bombyx mori Silkmoth  Bmor\BmorCPR27 Y Bombyx mori Silkmoth  Bmor\BmorCPR18 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002549 Y Bombyx mori Silkmoth  Bmor\BmorCPR38 Y Bombyx mori Silkmoth  Bmor\BmorCPR43 Y Bombyx mori Silkmoth  Bmor\BmorCPR42 Y Bombyx mori Silkmoth  Bmor\BmorCPR32 Y Bombyx mori Silkmoth  Bmor\BmorCPR49 Y Bombyx mori Silkmoth  Bmor\BmorCPR13 Y Bombyx mori Silkmoth  Bmor\BmorCPR9 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005277 Y Bombyx mori Silkmoth  Bmor\BmorCPR19 Y Pediculus humanus Human body louse  Phum\PHUM392770 Y Pediculus humanus Human body louse  Phum\PHUM605650 Y Pediculus humanus Human body louse  Phum\PHUM392750 Y Pediculus humanus Human body louse  Phum\PHUM605980 Y Pediculus humanus Human body louse  Phum\PHUM601840 Y Pediculus humanus Human body louse  Phum\PHUM606390 Y Pediculus humanus Human body louse  Phum\PHUM392730 Y Tribolium castaneum Red flour beetle  Tcas\TC013127 Y Tribolium castaneum Red flour beetle  Tcas\TC014500 Y Tribolium castaneum Red flour beetle  Tcas\TC014499 Y Tribolium castaneum Red flour beetle  Tcas\TC013131 Y Tribolium castaneum Red flour beetle  Tcas\TC014685 Y Tribolium castaneum Red flour beetle  Tcas\TC003831 Y Tribolium castaneum Red flour beetle  Tcas\TC013307 Y Tribolium castaneum Red flour beetle  Tcas\TC003834 Y Tribolium castaneum Red flour beetle  Tcas\TC013129 Y Tribolium castaneum Red flour beetle  Tcas\TC003832 Y Tribolium castaneum Red flour beetle  Tcas\TC014497 Y Tribolium castaneum Red flour beetle  Tcas\TC014770 Y Tribolium castaneum Red flour beetle  Tcas\TC013139 Y Tribolium castaneum Red flour beetle  Tcas\TC014771 Y Tribolium castaneum Red flour beetle  Tcas\TC013128 Y Tribolium castaneum Red flour beetle  Tcas\TC014498 Y Tribolium castaneum Red flour beetle  Tcas\TC014686 Y Tribolium castaneum Red flour beetle  Tcas\TC003830 Y Tribolium castaneum Red flour beetle  Tcas\TC003835 Y Tribolium castaneum Red flour beetle  Tcas\TC013138 Y Tribolium castaneum Red flour beetle  Tcas\TC004547 Y Tribolium castaneum Red flour beetle  Tcas\TC013130 Y Tribolium castaneum Red flour beetle  Tcas\TC013135 Y Tribolium castaneum Red flour beetle  Tcas\TC014720 Y Tribolium castaneum Red flour beetle  Tcas\TC002595 Y Tribolium castaneum Red flour beetle  Tcas\TC013126 Y Tribolium castaneum Red flour beetle  Tcas\TC004548 Y
Orthologs in non-Insect Arthropods (EOG63R24R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Map1d Y Daphnia pulex Water flea  Dpux\JGI_V11_253508 Y Daphnia pulex Water flea  Dpux\JGI_V11_58106 Y Daphnia pulex Water flea  Dpux\JGI_V11_263371 Y Daphnia pulex Water flea  Dpux\EF-1 alpha Y Daphnia pulex Water flea  Dpux\Psma3 Y Daphnia pulex Water flea  Dpux\MESK4 Y Daphnia pulex Water flea  Dpux\JGI_V11_60605 Y Daphnia pulex Water flea  Dpux\JGI_V11_303748 Y Daphnia pulex Water flea  Dpux\ycf9 Y Daphnia pulex Water flea  Dpux\Nktr Y Daphnia pulex Water flea  Dpux\JGI_V11_60650 Y Daphnia pulex Water flea  Dpux\JGI_V11_302740 Y Daphnia pulex Water flea  Dpux\JGI_V11_325416 Y Daphnia pulex Water flea  Dpux\PB2 Y Daphnia pulex Water flea  Dpux\JGI_V11_229448 Y Daphnia pulex Water flea  Dpux\JGI_V11_263370 Y Daphnia pulex Water flea  Dpux\JGI_V11_303733 Y Daphnia pulex Water flea  Dpux\JGI_V11_332302 Y Daphnia pulex Water flea  Dpux\JGI_V11_224365 Y Daphnia pulex Water flea  Dpux\JGI_V11_301237 Y Daphnia pulex Water flea  Dpux\Wbp4 Y Daphnia pulex Water flea  Dpux\JGI_V11_229447 Y Daphnia pulex Water flea  Dpux\CLDN25 Y Daphnia pulex Water flea  Dpux\ND1 Y Daphnia pulex Water flea  Dpux\JGI_V11_302183 Y Daphnia pulex Water flea  Dpux\JGI_V11_110014 Y Daphnia pulex Water flea  Dpux\mp20 Y Daphnia pulex Water flea  Dpux\JGI_V11_325539 Y Daphnia pulex Water flea  Dpux\JGI_V11_302739 Y Daphnia pulex Water flea  Dpux\JGI_V11_219079 Y Daphnia pulex Water flea  Dpux\Prc1 Y Daphnia pulex Water flea  Dpux\JGI_V11_109945 Y Daphnia pulex Water flea  Dpux\PB1-F2 Y Daphnia pulex Water flea  Dpux\JGI_V11_64995 Y Daphnia pulex Water flea  Dpux\JGI_V11_332314 Y Ixodes scapularis Deer tick  Isca\ISCW003132 Y Ixodes scapularis Deer tick  Isca\ISCW003791 Y Ixodes scapularis Deer tick  Isca\ISCW020944 Y Ixodes scapularis Deer tick  Isca\ISCW019775 Y Ixodes scapularis Deer tick  Isca\ISCW002954 Y Ixodes scapularis Deer tick  Isca\ISCW020943 Y Ixodes scapularis Deer tick  Isca\ISCW016302 Y Ixodes scapularis Deer tick  Isca\ISCW013798 Y Ixodes scapularis Deer tick  Isca\ISCW016310 Y Ixodes scapularis Deer tick  Isca\ISCW007107 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR09G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP01749 LP05686 RE01644 RE10603
Other clones	FI01403 FI09408
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP03676 LP05589 LP07704 RE09487 RE10928 RE21028 RE28204 RE32909 RE44450 RE44535 RE47575 RE65010 RE74528
Other clones	33149 59080 EK142812 EK183251 RM06685 RM06785 RM07385 RP01464 RP001002662 RP001017017 RP001023044 RP001026227 RP001040245 RP001047649 RP001055182 RP004119643 RP004158027 RP004192874 RP004236785 RP004238925 RP004390047 RP004424474 RP004529308 RP004531603 RP004532675 RP004550988 RP004558657
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020638 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38703
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Lcp65Ag1 CG10530 (Gabrielian, 1999.11)
Source for database merge of
Additional comments
Other Comments
	First identified by protein electrophoresis as LCP8; molecular studies showed that a protein of this mobility is coded by two genes in the cuticle protein gene cluster in 65A, Lcp65Ag1 and Lcp65Ag2. An electrophoretic allele of LCP8 was identified. This is listed under Lcp65Ag1; it may be a Lcp65Ag2 allele.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057925 RefSeq (Proteins) • NP_477273 DDBJ / EMBL / GenBank • AAB88071 AAF50692 AC004357 AC004767 U84753 Entrez Gene - A searchable database of RefSeq genes. • 38703 UniProtKB/Swiss-Prot • P92201
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64158 DroID - A comprehensive database of gene and protein interactions. • FBgn0020638 DRSC - Results from RNAi screens. • FBgn0020638 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020638 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020638 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38703 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38703 modMine - Data generated by the modENCODE project. • FBgn0020638
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG10530   DCP8-alpha   L3CP8 (Chihara and Kimbrell, 1986) LCP8 (Charles et al., 1998, Chihara et al., 1982) Lcp8   Lcp65Ag1 (Willis, 2007.1.3, Karouzou et al., 2007, Karouzou et al., 2007, Karouzou et al., 2007, Blanco et al., 2008) Lcp-g1 (Charles et al., 1998)
Name Synonym	Lcp65Ag1
Secondary FlyBase IDs
	FBgn0002539
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 6 ) Review  ( 1 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) Book  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...