FlyBase Gene Report: Dmel\eIF4B

General Information

Symbol

Dmel\eIF4B

Species

D. melanogaster

Name

eukaryotic translation initiation factor 4B

Annotation Symbol

CG10837

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020660

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

eukaryotic translation initiation factor 4B (eIF4B) encodes a protein involved in cap-dependent translation, cell survival, and proliferation. [Date last reviewed: 2019-07-11]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

eIF-4B

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:27,842,669..27,858,271 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:27842669..27858271

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables translation initiation factor activity

inferred from physical interaction with FLYBASE:eIF4E1; FB:FBgn0015218

(Duncan et al., 1995)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in translational initiation

inferred from physical interaction with FLYBASE:eIF4E1; FB:FBgn0015218

(Duncan et al., 1995)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in eukaryotic translation initiation factor 4F complex assembly

inferred from electronic annotation with InterPro:IPR033107

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Hernandez et al., 2004)

inferred from physical interaction with FLYBASE:eIF4E1; FB:FBgn0015218

(Duncan et al., 1995)

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYTOPLASMIC TRANSLATION INITIATION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC TRANSLATION INITIATION FACTORS -: Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\eIF4B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

eIF4B-RA

FBtr0113681

NM_001015321

1651

390

eIF4B-RB

FBtr0113680

NM_001015319

1504

459

eIF4B-RE

FBtr0113679

NM_001015320

1575

389

eIF4B-RF

FBtr0334940

NM_001276232

1443

392

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

eIF4B-PA

FBpp0112404

44.2

390

6.08

NP_001015321

EAA46128

eIF4B-PB

FBpp0112403

52.2

459

6.95

NP_001015319

EAA46129

eIF4B-PE

FBpp0112402

44.1

389

6.08

NP_001015320

EAA46131

eIF4B-PF

FBpp0306959

44.5

392

6.60

NP_001263161

ELP57406

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4B using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Hernandez et al., 2004)

inferred from physical interaction with FLYBASE:eIF4E1; FB:FBgn0015218

(Duncan et al., 1995)

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{769.FSVS-1}eIF4B^CPTI002187

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eIF4B in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eIF4B

View exonic expression by tissue for Dmel\eIF4B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020660

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020660

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10837-RE;CG10837-RE;CG10837-RB;CG10837-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10837

Flygut - An atlas of the Drosophila adult midgut

FBgn0020660

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eIF4B

Transgenic constructs containing regulatory region of eIF4B

Deletions and Duplications ( 13 )

Disrupted in

Df(3L)1-16

(Marygold et al., 2007)

Df(3L)1-166

(Syrzycka et al., 2019)

Df(3L)2-30

(Syrzycka et al., 2019)

Df(3L)2A-54

(Syrzycka et al., 2019)

Df(3L)9-56

(Syrzycka et al., 2019)

In(3L)C90

(Syrzycka et al., 2019)

Not disrupted in

Df(2R)247

(Coulthard and Alm, 2010.7.21)

Df(3L)5A-406

(Syrzycka et al., 2019)

Df(3L)7B-75

(Syrzycka et al., 2019)

Df(3L)10A-301

(Syrzycka et al., 2019)

Df(3L)FX33

(Syrzycka et al., 2019)

Df(3L)K-2

(Syrzycka et al., 2019)

Df(3L)TTT

(Syrzycka et al., 2019)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^da.G32

eIF4B^HMS04503

viable, with Scer\GAL4^Mef2.PR

eIF4B^GD7103

viable, with Scer\GAL4^pnr-MD237

eIF4B^GD7103

viable, with Scer\GAL4^tin.CΔ4

eIF4B^GD7103

viable, with Scer\GAL4^Tub.PU

Sterility

Allele

fertile, with Scer\GAL4^Tub.PU

Other Phenotypes

Allele

cell growth defective, with Scer\GAL4^Act.PU

eIF4B^L.UAS

size defective, with Scer\GAL4^Tub.PU

eIF4B^GD7103

visible, with Scer\GAL4^GMR.PF

eIF4B^L.UAS

Phenotype manifest in

Allele

chaeta | supernumerary, with Scer\GAL4^GMR.PF

eIF4B^L.UAS

eye, with Scer\GAL4^GMR.PF

eIF4B^L.UAS

macrochaeta, with Scer\GAL4^Tub.PU

eIF4B^GD7103

ommatidium, with Scer\GAL4^GMR.PF

eIF4B^L.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (28)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\EIF4B

12 of 15

Yes

Hsap\EIF4H

4 of 15

Hsap\BOLL

1 of 15

Hsap\CIRBP

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (30)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Eif4b

11 of 15

Yes

Mmus\Eif4h

3 of 15

Mmus\Boll

1 of 15

Mmus\Cirbp

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (26)

Rnor\Eif4b

10 of 13

Yes

Rnor\Eif4h

3 of 13

Rnor\Boll

1 of 13

Rnor\Cirbp

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (22)

Xtro\eif4b

10 of 12

Yes

Xtro\eif4h

4 of 12

Xtro\cirbp

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (29)

Drer\eif4bb

12 of 15

Yes

Drer\eif4ba

11 of 15

Yes

Drer\eif4h

4 of 15

Drer\cirbpa

1 of 15

Yes

Drer\cirbpb

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\zgc:55733

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\drr-2

2 of 15

Yes

Cele\daz-1

1 of 15

Cele\H05C05.1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\NUC-L1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (16)

Scer\TIF3

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\MUD1

1 of 15

Scer\NAB3

1 of 15

Scer\NAB6

1 of 15

Yes

Scer\NAM8

1 of 15

Scer\NGR1

1 of 15

Scer\NOP6

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\sce3

7 of 12

Yes

Spom\gar2

1 of 12

Spom\SPBC365.04c

1 of 12

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A82 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila willistoni

Dwil\GK27265

Drosophila virilis

Dvir\GJ25690

Drosophila mojavensis

Dmoj\GI23629

Drosophila grimshawi

Dgri\GH18041

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507JX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17004998

Glossina morsitans

Tsetse fly

Gmor\GMOY009478

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03901

Mayetiola destructor

Hessian fly

Mdes\Mdes000241

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009646

Anopheles gambiae

Malaria mosquito

Agam\AGAP000526

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ017755

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07WV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006463

Danaus plexippus

Monarch butterfly

Dple\DPOGS208296-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008374

Apis florea

Little honeybee

Aflo\2171968852

Apis mellifera

Western honey bee

Amel\LOC409560

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24468

Bombus terrestris

Buff-tailed bumblebee

Bter\15211991

Linepithema humile

Argentine ant

Lhum\LH23598

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001628

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009055

Tribolium castaneum

Red flour beetle

Tcas\TC011031

Pediculus humanus

Human body louse

Phum\PHUM259900

Rhodnius prolixus

Kissing bug

Rpro\RPRC015344

Cimex lectularius

Bed bug

Clec\CLEC004020

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008088

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00773

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0NFE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007036

Ixodes scapularis

Black-legged tick

Isca\ISCW018203

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75123.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g08810

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_340635

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_261723

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_325769

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DWC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Etif4BL

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000016816

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027699

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (26)

Gene Symbol

Score

Source

Alignment

5 of 10

4 of 10

3 of 10

2 of 10

bol

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

ssx

1 of 10

Sxl

1 of 10

tra2

1 of 10

trv

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

eIF4B^GD7103

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Linsalata et al., 2019)

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Linsalata et al., 2019)

eIF4B^HMS04503

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis-1

modeled by Zzzz\GGGGCC^{44.LDS.UAS.GR-GFP}

(Goodman et al., 2019)

eIF4B^VSH330010

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis-1

modeled by Zzzz\GGGGCC^{44.LDS.UAS.GR-GFP}

(Goodman et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EIF4B; eukaryotic translation initiation factor 4B

12 of 15

603928

EIF4H; eukaryotic translation initiation factor 4H

4 of 15

603431

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

eIF4B - CG11771

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - CG12768

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - CG30344

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - CG31125

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - CG9377

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - Calr

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - Chd64

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - Cyp4ae1

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - Gip

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - Mes2

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - TyrRS

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - bmm

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - capt

experimental knowledge based

(Guruharsha et al., 2011)

eIF4B - msl-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Mendjan et al., 2006)

RNA-protein

Physical Interaction

Assay

References

eIF4B - Ubx

nucleic acid uv cross-linking assay, autoradiography

(Hernandez et al., 2004)

eIF4B - cad

nucleic acid uv cross-linking assay, autoradiography

(Hernandez et al., 2004)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

78166

DroID - A comprehensive database of gene and protein interactions.

FBgn0020660

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3355041

MIST (protein-protein) - An integrated Molecular Interaction Database

eIF-4B

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

Sequence location

3L:27,842,669..27,858,271 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

h48-h48

(determined by in situ hybridisation)

(Rossi et al., 2007)

Heterochromatic, cytological location not yet determined.

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

61727

y¹ w^*; Mi{MIC}eIF4B^MI14258

57305

y¹ sc^* v¹ sev²¹; P{TRiP.HMS04503}attP40

Kyoto

115372

w¹¹¹⁸; PBac{769.FSVS-1}eIF4B^CPTI002187

VDRC

v330010

P{VSH330010}attP40

v31364

w¹¹¹⁸; P{GD7103}v31364

v318291

PBac{fTRG00939.sfGFP-TVPTBF}VK00033

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (26)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020660

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020660

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3355041

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Na et al., 2016)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: eIF4B eIF-4B

(Marygold et al., 2017)

Source for database merge of

Additional comments

Other Comments

eIF-4B is incorrectly located to 2Rh in FlyBase - it's actually in 3Lh (see data on the CP000217 scaffold in FBrf0200204). (Statement true as of FB2010_06.)

(Coulthard and Alm, 2010.7.21)

A major phosphoprotein which co-purifies with eIF-4E on m⁷GTP-Sepharose and shows decreased phosphorylation and association with eIF-4E after heat shock has been identified. This phosphoprotein may correspond to eIF-4B.

(Duncan et al., 1995)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3355041

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020660

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020660

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10837

Flygut - An atlas of the Drosophila adult midgut

FBgn0020660

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3355041

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10837

modMine - A data warehouse for the modENCODE project

FBgn0020660

Linkouts

BioGRID - A database of protein and genetic interactions.

78166

DPiM - Drosophila Protein interaction map

FBgn0020660

DroID - A comprehensive database of gene and protein interactions.

FBgn0020660

DRSC - Results frm RNAi screens

FBgn0020660

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0020660

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10837-RE;CG10837-RE;CG10837-RB;CG10837-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020660

FlyMine - An integrated database for Drosophila genomics

FBgn0020660

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3355041

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

eIF-4B

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG10837

(Vasudevan et al., 2020, Syrzycka et al., 2019, Marygold et al., 2017, Meadows, 2017.1.11, Çiçek et al., 2016, Na et al., 2016, Meadows, 2014.12.12, Ni et al., 2010.12.1, Perkins et al., 2009, Drosophila Heterochromatin Genome Project, 2007, Rossi et al., 2007, Hernandez et al., 2004, Robertson, 2001.1.8)

Dm-eIF4B

(Hernandez et al., 2004)

EIF-4B

(Mendjan et al., 2006)

EIF4B

(Linsalata et al., 2019)

Eif4B

eIF-4B

(Syrzycka et al., 2019, Hu et al., 2016, Na et al., 2016, Sarov et al., 2016, Völker-Albert et al., 2016, Ashwal-Fluss et al., 2014, Mukherjee et al., 2014, Coulthard and Alm, 2010.7.21, Marygold et al., 2007, Rossi et al., 2007, Muller et al., 2005)

eIF-4B-L

(Hernandez and Vazquez-Pianzola, 2005)

eIF-4B-S

(Hernandez and Vazquez-Pianzola, 2005)

eIF-4b

(Coulthard and Alm, 2010.7.21)

eIF4B

(Vandehoef et al., 2020, Vasudevan et al., 2020, Goodman et al., 2019, Linsalata et al., 2019, Rode et al., 2018, Marygold et al., 2017, Olson et al., 2013, Hernandez and Vazquez-Pianzola, 2005, Lasko, 2000)

eIF4B-L

(Hernandez and Vazquez-Pianzola, 2005)

eIF4B-S

(Hernandez and Vazquez-Pianzola, 2005)

eIf4b

(Coulthard and Alm, 2010.7.21)

Name Synonyms

Eukaryotic initiation factor 4B

(Duncan et al., 1995)

eukaryotic translation initiation factor 4B

Secondary FlyBase IDs

FBgn0040057
FBan0010837

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

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