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Gene Dmel\Su(z)12

General Information
Symbol	Dmel\Su(z)12	Species	D. melanogaster
Name	Su(z)12	Annotation symbol	CG8013
Feature type	protein_coding_gene	FlyBase ID	FBgn0020887
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(3)76BDo
Genomic Location
Chromosome (arm)	3L	Recombination map	3-49.5
Cytogenetic map	76D4-76D4	Sequence location	3L:19,911,342..19,916,562 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Su(z)12 is referred to in FlyBase by the symbol Dmel\Su(z)12 (CG8013, FBgn0020887). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; nucleosome binding; histone methyltransferase activity. There is experimental evidence that it is involved in the biological process: negative regulation of response to gamma radiation; histone methylation; dendrite morphogenesis; neuron development; muscle organ development; neurogenesis. 16 alleles are reported. The phenotypes of these alleles are annotated with: antenna; metathoracic metatarsus; mesothoracic tergum; mesothoracic metatarsus; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Polycomb protein, VEFS-Box; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623952_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Su(z)12. Gene sequence location is 3L:19911342..19916562.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms negative regulation of response to gamma radiation
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76D4-76D4   Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103
Experimentally Determined Cytological Location
Cytogenetic map Notes References 76E-76F     (Birve, 1999.5.7) 76E-77B   (determined by in situ hybridisation)   (Birve and Rasmuson-Lestander, 1997)
Experimentally Determined Recombination Data
Location	3-49.5 (Birve and Rasmuson-Lestander, 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Su(z)12 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Su(z)12-RA FBtr0074916  NM_143802   4098   855 Su(z)12-RB FBtr0074917  NM_168826   3936   900
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Su(z)12-PA   FBpp0074685   95.3   855   7.28     NP_652059   AAF49094 Su(z)12-PB   FBpp0074686   100.1   900   9.19     NP_730465   AAN11641
Additional Polypeptide Data & Comments
Reported size (kDa)	900 (aa); 105 (kD) (Muller et al., 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Polycomb protein, VEFS-Box (IPR019135)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438961   AA816533   AE014296 AAF49094   AE014296 AAN11641   AF149047 AAF73149   AI531264   AI533210   AI534041   AI944678   AW944394   AX094266   AY069809 AAL39954   BI171540   BI484016   BI484750   BI486204   CO177996   CO268897   CO279575   CO295561   CO295764   CO306628   CO306632   CO309782   CO311429   CO331100   CO341120   CO341352   EC060812   EC075479   EC197188   EC202333   EC203073   EC228005   EC232768   EC236035   EC248890   EC252176   EC257121   EV591071   EV591258
UniProtKB/Swiss-Prot	Q9NJG9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References insertion site P{}Su(z)12[1] 3L:19,913,975..19,913,977 evidence=experimental comment=P{}Su(z)121 is inserted into codon 564 of Su(z)12. The orientation of the insertion was not reported. (Birve et al., 2001)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
ESC/E(Z) complex inferred from direct assay (Muller et al., 2002, Czermin et al., 2002, Ohno et al., 2008, Herz et al., 2012) histone methyltransferase complex inferred from direct assay (Ketel et al., 2005) nucleus inferred from direct assay (Klymenko et al., 2006, Czermin et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary    645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary  (645.4) Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary    645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary    645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary    645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary  645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary    645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    358.625 Larval Midgut    128.7 Larval Hindgut    145.8 Larval Malpighian Tubules    200.2 Larval Fat Body    141.7 Larval Salivary Gland    282.3 Larval Trachea    281.025 Larval Carcass    167.875 Adult Head    58.5 Adult Eye    86.45 Adult Brain    160.1 Adult Thoracic-Abdominal Ganglion    113.8 Adult Crop    98.3 Adult Midgut    70.7 Adult Hindgut    79.4 Adult Malpighian Tubules    115.7 Adult Fat Body    106.4 Adult Salivary Gland    169.6 Adult Heart    112.75 Adult VirginFemale Spermatheca    123 Adult InseminatedFemale Spermatheca    134.7 Adult Ovary    645.4 Adult Testis    57.2 Adult Male Accessory Gland    131.7 Adult Carcass    95.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    58.5   NA  Eye    86.45   NA  Brain    160.1   358.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    113.8   NA  Crop    98.3   128.7  Midgut    70.7   145.8  Hindgut    79.4   200.2  Malpighian Tubules    115.7   141.7  Fat Body    106.4   282.3  Salivary Gland    169.6   NA  Heart    112.75   281.025  Trachea    NA   NA  VirginFemale Spermatheca    123   NA  InseminatedFemale Spermatheca    134.7   NA  Ovary    645.4   NA  Testis    57.2   NA  Male Accessory Gland    131.7   167.875  Carcass    95.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    54 ovary, mated 4-day female    54 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3  (29) central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female  (54) ovary, mated 4-day female  (54) testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    54 ovary, mated 4-day female    54 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    54 ovary, mated 4-day female    54 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    54 ovary, mated 4-day female    54 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3  29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female  (54) ovary, mated 4-day female  (54) testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    54 ovary, mated 4-day female    54 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    29 central nervous system, pupae P8    10 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    17 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    54 ovary, mated 4-day female    54 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    38 embryo 04-06hr    59 embryo 06-08hr    40 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (61) embryo 02-04hr  (38) embryo 04-06hr  (59) embryo 06-08hr  (40) embryo 08-10hr  26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day  (38) adult female 30day  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    38 embryo 04-06hr    59 embryo 06-08hr    40 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    38 embryo 04-06hr    59 embryo 06-08hr    40 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day    38 adult female 30day    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    38 embryo 04-06hr    59 embryo 06-08hr    40 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (61) embryo 02-04hr  (38) embryo 04-06hr  (59) embryo 06-08hr  (40) embryo 08-10hr  26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day  (38) adult female 30day  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    38 embryo 04-06hr    59 embryo 06-08hr    40 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    38 embryo 04-06hr    59 embryo 06-08hr    40 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    13 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    9 adult female 01day    24 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    46 embryonic 1182-4H    27 embryonic GM2    36 embryonic Kc167    29 embryonic S1    31 embryonic S3    20 leg disc CME L1    51 wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    33 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS    51 ovary OSC    28 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (46) embryonic 1182-4H  (27) embryonic GM2  (36) embryonic Kc167  (29) embryonic S1  (31) embryonic S3    20 leg disc CME L1  (51) wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3  (28) wing disc ML-DmD21  (33) wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS  (51) ovary OSC  (28) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    46 embryonic 1182-4H    27 embryonic GM2    36 embryonic Kc167    29 embryonic S1    31 embryonic S3    20 leg disc CME L1    51 wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    33 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS    51 ovary OSC    28 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    46 embryonic 1182-4H    27 embryonic GM2    36 embryonic Kc167    29 embryonic S1    31 embryonic S3    20 leg disc CME L1    51 wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    33 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS    51 ovary OSC    28 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    46 embryonic 1182-4H    27 embryonic GM2    36 embryonic Kc167    29 embryonic S1    31 embryonic S3    20 leg disc CME L1    51 wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    33 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS    51 ovary OSC    28 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (46) embryonic 1182-4H  27 embryonic GM2  (36) embryonic Kc167  29 embryonic S1  31 embryonic S3    20 leg disc CME L1  (51) wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3  28 wing disc ML-DmD21  (33) wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS  (51) ovary OSC  28 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    46 embryonic 1182-4H    27 embryonic GM2    36 embryonic Kc167    29 embryonic S1    31 embryonic S3    20 leg disc CME L1    51 wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    33 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS    51 ovary OSC    28 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    46 embryonic 1182-4H    27 embryonic GM2    36 embryonic Kc167    29 embryonic S1    31 embryonic S3    20 leg disc CME L1    51 wing disc CME-W2    18 wing disc ML-DmD8    21 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    33 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    13 ovary fGS/OSS    51 ovary OSC    28 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (32) Paraquat 10 mM 48 hrs, 4-day adult  (30) Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  32 Paraquat 10 mM 48 hrs, 4-day adult  30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • SD04959 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020887 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8013-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Su(z)12GD15573 lethal | embryonic stage | recessive Su(z)121 lethal | larval stage | recessive Su(z)121 Su(z)122 Su(z)123 Su(z)124 lethal | recessive Su(z)122 Su(z)123 Su(z)124 Su(z)125 viable, with Scer\GAL4pnr-MD237 Su(z)12GD15573 Other Phenotypes Allele decreased cell number | somatic clone Su(z)121 mitotic cell cycle defective | somatic clone Su(z)121 neuroanatomy defective Su(z)122 Su(z)125 neuroanatomy defective (with Su(z)122) Su(z)125 neuroanatomy defective (with Su(z)125) Su(z)122 neuroanatomy defective | larval stage Su(z)12GD15573 neuroanatomy defective | somatic clone Su(z)121 Su(z)124 suppressor of variegation | dominant, with In(1)wm4 Su(z)121 Su(z)122 Su(z)123 Su(z)124 Su(z)125 visible, with Scer\GAL4pnr-MD237 Su(z)12GD15573 visible | homeotic | pharate adult stage (with Su(z)123) Su(z)125 visible | homeotic | pharate adult stage (with Su(z)124) Su(z)125 visible | homeotic | pharate adult stage (with Su(z)125) Su(z)123 Su(z)124 visible | somatic clone Su(z)1233A8 Su(z)1233C2 Su(z)1233C4 Su(z)1233P6 Su(z)12974 Su(z)122036 Su(z)12daed Phenotype manifest in Allele antenna (with Su(z)123) Su(z)125 antenna (with Su(z)125) Su(z)123 dendrite & dendritic arborising neuron Su(z)122 Su(z)125 dendrite & dendritic arborising neuron (with Su(z)122) Su(z)125 dendrite & dendritic arborising neuron (with Su(z)125) Su(z)122 dendrite & dendritic arborising neuron | somatic clone Su(z)121 dendrite & dorsal multidendritic neuron ddaC | somatic clone Su(z)124 egg | germline clone Su(z)121 embryonic/larval neuroblast | larval stage Su(z)12GD15573 embryonic abdominal segment | germline clone (with Df(3L)kto2) Su(z)122 Su(z)125 embryonic head segment | germline clone (with Df(3L)kto2) Su(z)122 Su(z)125 embryonic mesothoracic segment | germline clone (with Df(3L)kto2) Su(z)122 Su(z)125 embryonic metathoracic segment | germline clone (with Df(3L)kto2) Su(z)122 Su(z)125 embryonic prothoracic segment | germline clone (with Df(3L)kto2) Su(z)122 Su(z)125 ganglion mother cell | larval stage Su(z)12GD15573 haltere | ectopic (with Su(z)123) Su(z)125 haltere | ectopic (with Su(z)125) Su(z)123 leg | ectopic (with Su(z)123) Su(z)125 leg | ectopic (with Su(z)125) Su(z)123 mesothoracic metatarsus (with Su(z)123) Su(z)125 mesothoracic metatarsus (with Su(z)125) Su(z)123 mesothoracic tergum, with Scer\GAL4pnr-MD237 Su(z)12GD15573 metathoracic metatarsus (with Su(z)123) Su(z)125 metathoracic metatarsus (with Su(z)125) Su(z)123 neuroblast | somatic clone Su(z)121 sex comb | ectopic (with Su(z)123) Su(z)125 sex comb | ectopic (with Su(z)125) Su(z)123 wing (with Su(z)123) Su(z)125 wing (with Su(z)125) Su(z)123 wing | cell autonomous | somatic clone Su(z)12daed wing | cell non-autonomous | somatic clone Su(z)12daed wing | somatic clone Su(z)12daed Su(z)1233A8 Su(z)1233C2 Su(z)1233C4 Su(z)1233P6 Su(z)12974 Su(z)122036 wing hinge | cell non-autonomous | somatic clone Su(z)12daed
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Su(z)12 Class Mutagen Stocks Known lesion Su(z)123 ethyl methanesulfonate 2 Yes Su(z)122 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Su(z)124 ethyl methanesulfonate 1 Yes Su(z)121 gain of function allele P-element activity 0 Yes Su(z)122036 ethyl methanesulfonate 0 -- Su(z)1233A8 ethyl methanesulfonate 0 -- Su(z)1233C2 ethyl methanesulfonate 0 -- Su(z)1233C4 ethyl methanesulfonate 0 -- Su(z)1233P6 ethyl methanesulfonate 0 -- Su(z)125 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Su(z)12974 ethyl methanesulfonate 0 -- Su(z)12daed ethyl methanesulfonate 0 -- Su(z)12unspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Su(z)12 Class Mutagen Stocks Known lesion Su(z)12GD15573 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Su(z)12HMS00280 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(z)12JF01706 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ash1A16 (Cooper et al., 2010) Df(3L)BSC2 (Cooper et al., 2010) Df(3L)BSC445 (Cooper et al., 2010) Df(3L)ED4858 (Cooper et al., 2010) Df(3L)Exel9007 (Cooper et al., 2010) Df(3L)Exel9008 (Cooper et al., 2010) Df(3L)Exel9009 (Cooper et al., 2010) Df(3L)kto2 (Birve et al., 1999, Zirin and Mann, 2004, Zhu et al., 2005, Cooper et al., 2010) Df(3L)XS411 (Cooper et al., 2010) Df(3L)XS533 (Cooper et al., 2010) Df(3L)XS543 (Cooper et al., 2010) Df(3L)XS572 (Cooper et al., 2010) Df(3L)XS917 (Cooper et al., 2010) Df(3L)XS2182 (Cooper et al., 2010)
Not disrupted in	Df(3L)25-21 (Cooper et al., 2010) Df(3L)A23 (Cooper et al., 2010) Df(3L)BSC20 (Cooper et al., 2010) Df(3L)BSC417 (Cooper et al., 2010) Df(3L)ED228 (Cooper et al., 2010) Df(3L)ED4799 (Cooper et al., 2010) Df(3L)Exel6135 (Cooper et al., 2010) Df(3L)Exel9011 (Cooper et al., 2010) Df(3L)Exel9045 (Cooper et al., 2010) Df(3L)Exel9046 (Cooper et al., 2010) Df(3L)kto22 (Cooper et al., 2010) Df(3L)pipeA13 (Cooper et al., 2010) Df(3L)XS705 (Cooper et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15573} NA P{TRiP.HMS00280} NA P{TRiP.JF01706} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Su(z)121 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
contributes_to histone methyltransferase activity inferred from direct assay (Ohno et al., 2008) histone methyltransferase activity inferred from direct assay (Ketel et al., 2005) contributes_to nucleosome binding inferred from direct assay (Nekrasov et al., 2005) protein binding inferred from physical interaction with Pcl (assigned by UniProtKB) (Tie et al., 2003)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) histone methylation inferred from direct assay (Muller et al., 2002) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) negative regulation of response to gamma radiation inferred from mutant phenotype (Zhang et al., 2008) neurogenesis inferred from mutant phenotype (Bello et al., 2007, Neumüller et al., 2011) neuron development inferred from mutant phenotype (Parrish et al., 2006)
Cellular Component
CV term Evidence References
ESC/E(Z) complex inferred from direct assay (Muller et al., 2002, Czermin et al., 2002, Ohno et al., 2008, Herz et al., 2012) histone methyltransferase complex inferred from direct assay (Ketel et al., 2005) nucleus inferred from direct assay (Klymenko et al., 2006, Czermin et al., 2002)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
contributes_to histone methyltransferase activity (H3-K27 specific) inferred by curator from GO:0035098 (Muller et al., 2002)
Biological Process
CV term Evidence References
cell proliferation non-traceable author statement (Chen et al., 2003)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Chen et al., 2003) polytene chromosome band non-traceable author statement (Chen et al., 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Su(z)12 - CG1124 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(z)12 - E(z) anti bait coimmunoprecipitation, western blot (Tie et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Su(z)12 allele Gene References Su(z)121 Asx (Birve and Rasmuson-Lestander, 1994) Pc (Birve and Rasmuson-Lestander, 1994) Pcl (Birve and Rasmuson-Lestander, 1994) Scm (Birve and Rasmuson-Lestander, 1994) unspecified sens (Parrish et al., 2006) z (Birve and Rasmuson-Lestander, 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71118 DroID - A comprehensive database of gene and protein interactions. • FBgn0020887 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48071
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NGH65 Dipteran inclusive ortholog search EOG6N30X2 Insect inclusive ortholog search EOG6DND0C Arthropod inclusive ortholog search EOG62BVQJ Metazoa inclusive ortholog search EOG6Q8HQ9
Orthologs in Drosophila Species (EOG6NGH65)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Su(z)12     Drosophila simulans   Dsim\GD12239 Y   Drosophila sechellia   Dsec\GM15475 Y   Drosophila erecta   Dere\GG13361 Y   Drosophila yakuba   Dyak\GE22454 Y   Drosophila yakuba   Dyak\GE14721     Drosophila ananassae   Dana\GF10839 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20766 Y   Drosophila persimilis   Dper\GL22906 Y   Drosophila willistoni   Dwil\GK17218 Y   Drosophila virilis   Dvir\GJ11332 Y   Drosophila mojavensis   Dmoj\GI11653 Y   Drosophila grimshawi   Dgri\GH15126 Y
Orthologs in non-Drosophila Dipterans (EOG6N30X2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008578   Anopheles gambiae Malaria mosquito  Agam\AGAP011882   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013586   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013585
Orthologs in non-Dipteran Insects (EOG6DND0C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47335   Apis mellifera Western honey bee  Amel\GB47334   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000248   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10216   Atta cephalotes Leafcutter ant  Acep\ACEP20784   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15604   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19789   Linepithema humile Argentine ant  Lhum\LH23434   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14149   Solenopsis invicta Red fire ant  Sinv\SINV12487   Acyrthosiphon pisum Pea aphid  Apim\ACYPI085777   Bombyx mori Silkmoth  Bmor\BGIBMGA011842   Pediculus humanus Human body louse  Phum\PHUM186640   Tribolium castaneum Red flour beetle  Tcas\TC003521
Orthologs in non-Insect Arthropods (EOG62BVQJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Cops6   Ixodes scapularis Deer tick  Isca\ISCW023066
Orthologs in non-Arthropod Metazoa (EOG6Q8HQ9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013163gn   Danio rerio Zebrafish  Drer\suz12a   Danio rerio Zebrafish  Drer\suz12b   Xenopus tropicalis Western clawed frog  Xtro\suz12   Gallus gallus Domestic chicken  Ggal\SUZ12   Mus musculus House mouse  Mmus\Suz12   Homo sapiens Human  Hsap\SUZ12
Human Orthologs (1)
Gene OMIM HGNC Hsap\SUZ12
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12239 Drosophila sechellia Dsec\GM15475 Drosophila erecta Dere\GG13361 Drosophila yakuba Dyak\GE22454 Drosophila ananassae Dana\GF10839 Drosophila pseudoobscura pseudoobscura Dpse\GA20766 Drosophila persimilis Dper\GL22906 Drosophila willistoni Dwil\GK17218 Drosophila virilis Dvir\GJ11332 Drosophila mojavensis Dmoj\GI11653 Drosophila grimshawi Dgri\GH15126
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	31191 y1 v1; P{TRiP.JF01706}attP2 33402 y1 sc* v1; P{TRiP.HMS00280}attP2/TM3, Sb1 24469 w*; Su(z)124 P{FRT(whs)}2A e1/TM6C, Sb1 24159 w*; Su(z)122 P{FRT(whs)}2A/TM6C, Sb1 Tb1 5068 Su(z)123 red1 e*/TM6B, Sb1 Tb+ ca1
Kyoto	108016 Su(z)123 red1 e*/TM6B, Sb1 Tb1 ca1
VDRC	v42423 w1118; P{GD15573}v42423 v42422 w1118; P{GD15573}v42422/TM3
Genomic Clones ( 1 )
	BACR13N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD04959
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD02025 LD13365 RE13343 RE67029 RE67901 RE69595 SD02229 SD06516
Other clones	21181 28779 77368 78254 102813 120245 120247 194573 214471.46 214565.44 bs04b05 CK01.121D.F7 Dmel_neb_014568_0399_2642 Dmel_neb_015811_0444_1461 EK054936 EK093024 EK135411 EK210713 EK211537 EK219308 EK224534 EK251622 EK251626 EK298021 EP11912 EP12316
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020887 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48071
Antibody Information
	polyclonal (Muller et al., 2002, Tie et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Su(z)12 CG8013 (FlyBase, 1996-) Source for merge of: Su(z)12 l(3)76BDo (Birve et al., 2001)
Additional comments	Source for merge of Su(z)12 CG8013 was sequence comparison (date:000605). (FlyBase, 1996-)
Other Comments
	Su(z)12 is required for normal neuroblast proliferation in postembryonic central nervous system development. (Bello et al., 2007) Su(z)12 is required for for the maintenance of dendritic fields in class IV dendrite arborisation (da) neurons. (Parrish et al., 2007) dsRNA has been made from templates generated with primers directed against this gene. RNAi of Su(z)12 causes an increase in branch number and an expansion of the receptive field of class I neurons. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Area matching Drosophila EST AA438961. This EST has sequence similarity to Human KIAA0160 gene. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143802 NM_168826 RefSeq (Proteins) • NP_652059 NP_730465 DDBJ / EMBL / GenBank • AA438961 AA816533 AAF49094 AAF73149 AAL39954 AAN11641 AF149047 AI533210 AI944678 AW944394 AX094266 AY069809 Entrez Gene - A searchable database of RefSeq genes. • 48071 UniProtKB/Swiss-Prot • Q9NJG9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Polycomb protein, VEFS-Box (IPR019135) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD04959
Linkouts
	BioGRID - A database of protein and genetic interactions • 71118 DroID - A comprehensive database of gene and protein interactions. • FBgn0020887 DRSC - Results from RNAi screens. • FBgn0020887 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020887 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8013-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020887 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48071 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48071 modMine - Data generated by the modENCODE project. • FBgn0020887
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG8013 (Klebes et al., 2005, Ni et al., 2008, Ni et al., 2010.12.1) l(3)76BDo (Zhu et al., 2005, Kehle et al., 1998, Cooper et al., 2010) Su(z)12 (Chen and Rasmuson-Lestander, 2009, Qi et al., 2006, Schuettengruber et al., 2007, Papp and Muller, 2006, Parrish et al., 2006, Klymenko et al., 2006, Ji et al., 2012, Nowak et al., 2011, Gan et al., 2010, Chen et al., 2008, Bello et al., 2007, Muller and Kassis, 2006, Chen et al., 2008, Lin et al., 2008, Sengupta et al., 2004, Nekrasov et al., 2005, de Ayala Alonso et al., 2007, Schmitges et al., 2011, Anderson et al., 2011, Jungreis, 2011.11.18, Toku et al., 2011, Nekrasov et al., 2007, Zhang et al., 2008, Parrish et al., 2007, Oktaba et al., 2008, Tie et al., 2003, Gambetta et al., 2009, Gambetta et al., 2009, Classen et al., 2009, Anholt and Williams, 2010, Cooper et al., 2010, Prabhakaran and Kelley, 2010, Neumüller et al., 2011, Herz et al., 2012, Davis et al., 2011, Yuan et al., 2012, Touma et al., 2012, Stepanik and Harte, 2012) SU(Z)12 (Chopra and Mishra, 2005, Czermin et al., 2002, Schwartz and Pirrotta, 2007, Tegeling et al., 2007, Tie et al., 2012, Tie et al., 2005, Joshi et al., 2008, Ketel et al., 2005, Wang et al., 2006, Kurzhals et al., 2008, Joshi et al., 2008, Tie et al., 2009, Ohno et al., 2008) Su(Z)12 (Taylor-Harding et al., 2004, Wen et al., 2012) su(z)12 (Prabhakaran and Kelley, 2010) Su(z)12 (Maeda and Karch, 2006)
Name Synonym	Su(z)12 (Davis et al., 2011) Suppressor-of-zeste-12 (Chen and Rasmuson-Lestander, 2009) Suppressor of zeste 12 (Schuettengruber et al., 2007, Tegeling et al., 2007, Chen et al., 2008, Bello et al., 2007, Muller and Kassis, 2006, Classen et al., 2009, Herz et al., 2012) Suppressor of zeste12 (Maeda and Karch, 2006)
Secondary FlyBase IDs
	FBgn0025924 FBgn0036917
References ( 98 )
Generate a list of	All references relating to this gene ( 98 )
List References by type	Research paper  ( 56 ) Supplementary material  ( 5 ) Review  ( 10 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 15 ) FlyBase analysis  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 )
Recent research papers ( 13 )
	Herz et al., 2012, Mol. Cell. Biol. 32(9): 1683--1693 Polycomb repressive complex 2-dependent and -independent functions of jarid2 in transcriptional regulation in Drosophila. [FBrf0218000] Ji et al., 2012, G3 (Bethesda) 2(12): 1651--1660 In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila. [FBrf0220353] Stepanik and Harte, 2012, Dev. Biol. 364(2): 249--258 A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes. [FBrf0217758] Tie et al., 2012, Mol. Cell. Biol. 32(12): 2323--2334 Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27. [FBrf0218406] Touma et al., 2012, Development 139(4): 657--666 Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons. [FBrf0217274] Wen et al., 2012, Dev. Dyn. 241(3): 455--464 The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. [FBrf0217472] Yuan et al., 2012, Science 337(6097): 971--975 Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. [FBrf0219425] Anderson et al., 2011, Development 138(10): 1957--1966 The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. [FBrf0213580] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Nowak et al., 2011, J. Biol. Chem. 286(26): 23388--23396 Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites. [FBrf0213994] Schmitges et al., 2011, Mol. Cell 42(3): 330--341 Histone methylation by PRC2 is inhibited by active chromatin marks. [FBrf0214598] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...