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Gene Dmel\Scp2

General Information
Symbol	Dmel\Scp2	Species	D. melanogaster
Name	Sarcoplasmic calcium-binding protein 2	Annotation symbol	CG14904
Feature type	protein_coding_gene	FlyBase ID	FBgn0020907
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	dSCP2
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	89B20-89D4	Sequence location	3R:12,400,265..12,409,385 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sarcoplasmic calcium-binding protein 2 is referred to in FlyBase by the symbol Dmel\Scp2 (CG14904, FBgn0020907). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activity. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Calcium-binding EF-hand; EF-Hand 1, calcium-binding site; EF-hand-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1635398_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Scp2. Gene sequence location is 3R:12400265..12409385.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B20-89D4   Limits computationally determined from genome sequence between P{lacW}CSN5L4032 and P{EP}MESK4EP1015
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89D1-89D2     (Quattrone, 1998.9.19) 89D1-89D2     (Kelly, 1997.7.18) 89A-89A   (determined by in situ hybridisation)   (Kelly et al., 1997)
Experimentally Determined Recombination Data
Location	3- (Kelly, 1997.7.18)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Scp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Scp2-RA FBtr0083361  NM_079657   1283   184
Additional Transcript Data & Comments
Reported size (kB)	1.1 (longest cDNA) (Kelly et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Scp2-PA   FBpp0082806   21.3   184   4.16     NP_524381   AAF55336
Additional Polypeptide Data & Comments
Reported size (kDa)	184 (aa); 21 (kD predicted) (Kelly et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EF-Hand 1, calcium-binding site (IPR018247) EF-hand domain (IPR002048) EF-hand-like domain (IPR011992)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698856   AA801558   AE014297 AAF55336   AF014952 AAB67805   AF093240 AAC62484   AI106609   AI114191   AY089680 AAL90418   BG632161   BG632340   BI167594   BI240854   BI568420   BI606779   BI607134   BI610110   BI612576   BI617134   BI621077   BI625439   BT012494   BT025915   CO190549   CO265954   CO272011   CO275311   CO280622   CO313411   CO315515   CO320768   CO323886   CO328553   CO331733   EC060700   EC072979   EC089272   EC214012   EC215236   EC218361   EC235198   EC239264   EC241281   EC251023   EL872596   EL872840   EL872965   EL875466   EL879206   EL879560   EV595883
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O16158
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   Malpighian tubule primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic Malpighian tubule tip cell   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   neuron of adult brain | restricted   (Kelly et al., 1997)
Additional Descriptive Data
	Scp2 transcript is detected in neuronal cell bodies in the brain. Strongest hybridization is in two layers of cells in the the lamina or first optic ganglion, in cells lying between the medulla and lobula, in the central region of the brain separating the optic lobe from the protocerebrum, and in specific cell bodies in the central brain. (Kelly et al., 1997)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules    3962.8 Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head    1693.2 Adult Eye    4274.25 Adult Brain    1442.9 Adult Thoracic-Abdominal Ganglion    3065.6 Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules    3687.3 Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules  (3962.8) Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head  (1693.2) Adult Eye  (4274.25) Adult Brain  (1442.9) Adult Thoracic-Abdominal Ganglion  (3065.6) Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules  (3687.3) Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules  (3962.8) Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head  (1693.2) Adult Eye  (4274.25) Adult Brain  (1442.9) Adult Thoracic-Abdominal Ganglion  (3065.6) Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules  (3687.3) Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules    3962.8 Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head    1693.2 Adult Eye    4274.25 Adult Brain    1442.9 Adult Thoracic-Abdominal Ganglion    3065.6 Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules    3687.3 Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules    3962.8 Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head    1693.2 Adult Eye    4274.25 Adult Brain    1442.9 Adult Thoracic-Abdominal Ganglion    3065.6 Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules    3687.3 Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules  (3962.8) Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head  (1693.2) Adult Eye  (4274.25) Adult Brain  (1442.9) Adult Thoracic-Abdominal Ganglion  (3065.6) Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules  (3687.3) Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules  (3962.8) Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head  1693.2 Adult Eye  (4274.25) Adult Brain  1442.9 Adult Thoracic-Abdominal Ganglion  (3065.6) Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules  (3687.3) Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    141.775 Larval Midgut    14.3 Larval Hindgut    11.6 Larval Malpighian Tubules    3962.8 Larval Fat Body    12.3 Larval Salivary Gland    5.5 Larval Trachea    106.875 Larval Carcass    62.625 Adult Head    1693.2 Adult Eye    4274.25 Adult Brain    1442.9 Adult Thoracic-Abdominal Ganglion    3065.6 Adult Crop    4.7 Adult Midgut    7.3 Adult Hindgut    4.9 Adult Malpighian Tubules    3687.3 Adult Fat Body    89.2 Adult Salivary Gland    14.3 Adult Heart    13.65 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.1 Adult Testis    3.8 Adult Male Accessory Gland    5.4 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1693.2   NA  Eye    4274.25   NA  Brain    1442.9   141.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3065.6   NA  Crop    4.7   no informative data  Midgut    7.3   no informative data  Hindgut    4.9   3962.8  Malpighian Tubules    3687.3   no informative data  Fat Body    no informative data   5.5  Salivary Gland    no informative data   NA  Heart    13.65   106.875  Trachea    NA   NA  VirginFemale Spermatheca    4.7   NA  InseminatedFemale Spermatheca    4.3   NA  Ovary    2.1   NA  Testis    3.8   NA  Male Accessory Gland    5.4   62.625  Carcass    51.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    48 head, virgin 1-day female    96 head, virgin 4-day female    55 head, virgin 20-day female    30 head, mated 1-day female    72 head, mated 4-day female    56 head, mated 20-day female    26 head, mated 1-day male    114 head, mated 4-day male    86 head, mated 20-day male    69 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    58 digestive system, 4-day adult    55 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8  (48) head, virgin 1-day female  (96) head, virgin 4-day female  (55) head, virgin 20-day female  (30) head, mated 1-day female  (72) head, mated 4-day female  (56) head, mated 20-day female  26 head, mated 1-day male  (114) head, mated 4-day male  (86) head, mated 20-day male  (69) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult  (58) digestive system, 4-day adult  (55) digestive system, 20-day adult  (36) fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    48 head, virgin 1-day female    96 head, virgin 4-day female    55 head, virgin 20-day female    30 head, mated 1-day female    72 head, mated 4-day female    56 head, mated 20-day female    26 head, mated 1-day male  (114) head, mated 4-day male    86 head, mated 20-day male    69 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    58 digestive system, 4-day adult    55 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    48 head, virgin 1-day female    96 head, virgin 4-day female    55 head, virgin 20-day female    30 head, mated 1-day female    72 head, mated 4-day female    56 head, mated 20-day female    26 head, mated 1-day male    114 head, mated 4-day male    86 head, mated 20-day male    69 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    58 digestive system, 4-day adult    55 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    48 head, virgin 1-day female    96 head, virgin 4-day female    55 head, virgin 20-day female    30 head, mated 1-day female    72 head, mated 4-day female    56 head, mated 20-day female    26 head, mated 1-day male    114 head, mated 4-day male    86 head, mated 20-day male    69 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    58 digestive system, 4-day adult    55 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8  (48) head, virgin 1-day female  (96) head, virgin 4-day female  (55) head, virgin 20-day female  30 head, mated 1-day female  (72) head, mated 4-day female  (56) head, mated 20-day female  26 head, mated 1-day male  (114) head, mated 4-day male  (86) head, mated 20-day male  (69) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult  (58) digestive system, 4-day adult  (55) digestive system, 20-day adult  (36) fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    48 head, virgin 1-day female    96 head, virgin 4-day female    55 head, virgin 20-day female    30 head, mated 1-day female    72 head, mated 4-day female    56 head, mated 20-day female    26 head, mated 1-day male  114 head, mated 4-day male    86 head, mated 20-day male    69 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    58 digestive system, 4-day adult    55 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    48 head, virgin 1-day female    96 head, virgin 4-day female    55 head, virgin 20-day female    30 head, mated 1-day female    72 head, mated 4-day female    56 head, mated 20-day female    26 head, mated 1-day male    114 head, mated 4-day male    86 head, mated 20-day male    69 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    58 digestive system, 4-day adult    55 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    12 carcass, larvae L3 wandering    8 carcass, 1-day adult    19 carcass, 4-day adult    14 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2    36 larva L3 12hr old    66 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP    44 pupae 4d postWPP    59 adult male 01day    52 adult male 05day    30 adult male 30day    22 adult female 01day    35 adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2  (36) larva L3 12hr old  (66) larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP  (44) pupae 4d postWPP  (59) adult male 01day  (52) adult male 05day  (30) adult male 30day    22 adult female 01day  (35) adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2    36 larva L3 12hr old    66 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP    44 pupae 4d postWPP    59 adult male 01day    52 adult male 05day    30 adult male 30day    22 adult female 01day    35 adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2    36 larva L3 12hr old    66 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP    44 pupae 4d postWPP    59 adult male 01day    52 adult male 05day    30 adult male 30day    22 adult female 01day    35 adult female 05day    8 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2    36 larva L3 12hr old    66 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP    44 pupae 4d postWPP    59 adult male 01day    52 adult male 05day    30 adult male 30day    22 adult female 01day    35 adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2  (36) larva L3 12hr old  (66) larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP  (44) pupae 4d postWPP  (59) adult male 01day  (52) adult male 05day  30 adult male 30day    22 adult female 01day  (35) adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2    36 larva L3 12hr old    66 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP    44 pupae 4d postWPP    59 adult male 01day    52 adult male 05day    30 adult male 30day    22 adult female 01day    35 adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    24 larva L2    36 larva L3 12hr old    66 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    4 pupae 2d postWPP    12 pupae 3d postWPP    44 pupae 4d postWPP    59 adult male 01day    52 adult male 05day    30 adult male 30day    22 adult female 01day    35 adult female 05day    8 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • PC00291 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020907 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14904-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Scp2GD7705 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Scp2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Scp2 Class Mutagen Stocks Known lesion Scp2GD7705 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6270 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7705} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
GTPase activity inferred from direct assay (Nelson et al., 2003)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from sequence or structural similarity with UniProtKB:O76730 (FlyBase, 1992-) non-traceable author statement (Kelly, 1997.7.18) GTPase activity inferred from sequence or structural similarity with UniProtKB:O76730 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
sarcoplasmic reticulum inferred from sequence or structural similarity with UniProtKB:O76730 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Scp2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67060 DroID - A comprehensive database of gene and protein interactions. • FBgn0020907 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42015
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TB4XT Dipteran inclusive ortholog search EOG67WNXX Insect inclusive ortholog search EOG6W6MS8 Arthropod inclusive ortholog search EOG6NK9BV Metazoa inclusive ortholog search EOG62ZHJR
Orthologs in Drosophila Species (EOG6TB4XT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Scp2     Drosophila simulans   Dsim\GD20278 Y   Drosophila sechellia   Dsec\GM15421 Y   Drosophila erecta   Dere\GG16823 Y   Drosophila yakuba   Dyak\GE26142 Y   Drosophila ananassae   Dana\GF17935 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13342 Y   Drosophila persimilis   Dper\GL27293 Y   Drosophila willistoni   Dwil\GK22835 Y   Drosophila virilis   Dvir\GJ22847 Y   Drosophila mojavensis   Dmoj\GI10386 Y   Drosophila grimshawi   Dgri\GH20505 Y
Orthologs in non-Drosophila Dipterans (EOG67WNXX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010792   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010789   Anopheles gambiae Malaria mosquito  Agam\AGAP004645   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005976   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005975
Orthologs in non-Dipteran Insects (EOG6W6MS8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Scp2   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022716   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13757   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22940   Linepithema humile Argentine ant  Lhum\LH20766   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12301   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12302   Solenopsis invicta Red fire ant  Sinv\SINV25283   Solenopsis invicta Red fire ant  Sinv\SINV23052   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002599   Bombyx mori Silkmoth  Bmor\BGIBMGA006444   Bombyx mori Silkmoth  Bmor\BGIBMGA008815   Bombyx mori Silkmoth  Bmor\BGIBMGA008814   Tribolium castaneum Red flour beetle  Tcas\TC000753
Orthologs in non-Insect Arthropods (EOG6NK9BV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\gB   Ixodes scapularis Deer tick  Isca\ISCW017571
Orthologs in non-Arthropod Metazoa (EOG62ZHJR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cex-2   Caenorhabditis elegans Nematode  Cele\cex-1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20278 Drosophila sechellia Dsec\GM15421 Drosophila erecta Dere\GG16823 Drosophila yakuba Dyak\GE26142 Drosophila ananassae Dana\GF17935 Drosophila pseudoobscura pseudoobscura Dpse\GA13342 Drosophila persimilis Dper\GL27293 Drosophila willistoni Dwil\GK22835 Drosophila virilis Dvir\GJ22847 Drosophila mojavensis Dmoj\GI10386 Drosophila grimshawi Dgri\GH20505
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v31916 w1118; P{GD7705}v31916 v31918 w1118; P{GD7705}v31918
Genomic Clones ( 1 )
	BACR48L13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 44 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL05814 IP09412 RH52364
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04433 GH10906 HL06654 RE08012 RE37789 RH14987 RH39863 RH41502 RH47370 RH65860 RH73611 RH74138
Other clones	15265 34654 65155 107240 158763 159822 183168 273964 CK01.56C.H8 CK01.61C.G5 Dmel_neb_011531_0686_0453 EK048527 EK105449 EK117104 EK144547 EK154506 EK191818 EK232758 EK261725 EK288028 EK290851 EK301532 GH06666 IP04491 IP04691 IP04791 IP05470 IP09212 IP09512
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020907 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42015
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	cDNA identified using the DCABP-23 antibody. (Kelly et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079657 RefSeq (Proteins) • NP_524381 DDBJ / EMBL / GenBank • AA698856 AAB67805 AAC62484 AAF55336 AAL90418 AF014952 AF093240 AY089680 BI621077 Entrez Gene - A searchable database of RefSeq genes. • 42015 UniProtKB/TrEMBL • O16158
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EF-Hand 1, calcium-binding site (IPR018247) EF-hand domain (IPR002048) EF-hand-like domain (IPR011992) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00291
Linkouts
	BioGRID - A database of protein and genetic interactions • 67060 DroID - A comprehensive database of gene and protein interactions. • FBgn0020907 DRSC - Results from RNAi screens. • FBgn0020907 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020907 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14904-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020907 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42015 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42015 modMine - Data generated by the modENCODE project. • FBgn0020907
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CE (Nelson et al., 2003) cex (Nelson et al., 2003) Cex   CG14904   Dcabp-A.2 (Kelly et al., 1997) dSCP2 (Nelson et al., 2003, Maxwell et al., 2002) JHDK (Maxwell et al., 2002) SCP2 (Phillips et al., 2000, Kelly, 1997.7.18) Scp2 (Barmina et al., 2005)
Name Synonym	Ca2+-sensing low molecular weight GTPase   Calexcitin (Nelson et al., 2003) Cex Ca2+-sensing low molecular weight (Quattrone, 1998.9.19) Drosophila Ca2+-binding protein A.2 (Kelly et al., 1997) Sarcoplasmic calcium-binding protein 2
Secondary FlyBase IDs
	FBgn0025677
References ( 19 )
Research paper	Barmina et al., 2005, Dev. Biol. 288(2): 528--544 Sex- and segment-specific modulation of gene expression profiles in Drosophila. [FBrf0190088] Nelson et al., 2003, Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 135(4): 627--638 Calcium-regulated GTPase activity in the calcium-binding protein calexcitin. [FBrf0161996] Maxwell et al., 2002, J. Biol. Chem. 277(24): 21882--21890 Juvenile hormone diol kinase. [FBrf0149606] Phillips et al., 2000, J. Neurosci. 20(22): 8254--8261 The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin. [FBrf0131377] Kelly et al., 1997, Insect Biochem. Mol. Biol. 27(8/9): 783--792 Identification of a gene family from Drosophila melanogaster encoding proteins with homology to invertebrate sarcoplasmic calcium-binding proteins (SCPS). [FBrf0099787]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Quattrone, 1998.9.19, GenBank/EMBL/DDBJ: AF093240 Drosophila melanogaster Cex Ca2+-sensing low molecular weight GTPase mRNA, complete cds. [FBrf0119326] Kelly, 1997.7.18, GenBank/EMBL/DDBJ: AF014952 Drosophila melanogaster calcium-binding protein (SCP2) mRNA, complete cds. [FBrf0116845]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651] FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]