FB2025_01 , released February 20, 2025
Gene: Dmel\Scp2
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General Information
Symbol
Dmel\Scp2
Species
D. melanogaster
Name
Sarcoplasmic calcium-binding protein 2
Annotation Symbol
CG14904
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020907
Gene Model Status
Current
Stock Availability
42 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

JHDK, dSCP2, Calexcitin

Key Links
Genomic Location
Cytogenetic map
89B20-89D4
Sequence location
Recombination map
3-59
RefSeq locus
NT_033777 REGION:16574543..16583663
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables GTPase activity
inferred from direct assay
(Nelson et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR002048
(InterPro Project Members, 2004-)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Group (FlyBase)
UNCLASSIFIED GTPASES -
This group comprises GTPases that do not classify under other groups in FlyBase.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Scp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O16158)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Scp2-RA
FBtr0083361
NM_079657
1283
184
Additional Transcript Data and Comments
Reported size (kB)

1.1 (longest cDNA)

(Kelly et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Scp2-PA
FBpp0082806
21.3
184
4.16
O16158
NP_524381
AAF55336
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

184 (aa); 21 (kD predicted)

(Kelly et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Scp2 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.86

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
Malpighian tubule primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic Malpighian tubule tip cell
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of adult brain | restricted
(Kelly et al., 1997)
Additional Descriptive Data

Scp2 transcript is detected in neuronal cell bodies in the brain. Strongest hybridization is in two layers of cells in the the lamina or first optic ganglion, in cells lying between the medulla and lobula, in the central region of the brain separating the optic lobe from the protocerebrum, and in specific cell bodies in the central brain.

(Kelly et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Scp2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Scp2
Transgenic constructs containing regulatory region of Scp2
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6270
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\CETN3
1 of 14
Yes
No
1  
Hsap\DGKB
1 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Cetn3
1 of 14
Yes
No
Rnor\Dgkb
1 of 14
Yes
No
Rnor\Guca1a
1 of 14
Yes
No
Mus musculus (laboratory mouse) (2)
Mmus\Cetn3
1 of 14
Yes
No
Mmus\Guca1a
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (1)
Xtro\ppef1
1 of 13
Yes
No
Danio rerio (Zebrafish) (3)
Drer\calub
1 of 14
Yes
No
Drer\guca1e
1 of 14
Yes
No
Drer\kcnip1b
1 of 14
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\cex-1
8 of 14
Yes
Yes
Cele\cex-2
8 of 14
Yes
Yes
Cele\cal-8
1 of 14
No
No
Cele\chpf-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP004645
12 of 12
Yes
Yes
Agam\AgaP_AGAP001177
1 of 12
No
No
Agam\AgaP_AGAP006686
1 of 12
No
No
Agam\AgaP_AGAP007963
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AT2G41410
1 of 13
Yes
Yes
Atha\AT4G27790
1 of 13
Yes
No
Atha\AT5G08580
1 of 13
Yes
No
Atha\CPK15
1 of 13
Yes
No
Atha\CPK23
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CMD1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Scp2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
scf
2 of 13
Scp1
2 of 13
α-Spec
1 of 13
CBP
1 of 13
CG31650
1 of 13
Frq1
1 of 13
myd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Summary of Genetic Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-59
    Cytogenetic map
    89B20-89D4
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    89B20-89D4
    Limits computationally determined from genome sequence between P{lacW}CSN5L4032 and P{EP}MESK4EP1015
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    89D1-89D2
    (Quattrone, 1998.9.19, Kelly, 1997.7.18)
    89A-89A
    (determined by in situ hybridisation)
    (Kelly et al., 1997)
    Experimentally Determined Recombination Data
    Location

    3-59

    (FlyBase, 2016)

    3-58.7

    (Comeron et al., 2012)

    3-

    (Kelly, 1997.7.18)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (42)
    Genomic Clones (23)
    cDNA Clones (40)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Ortholog of B. mori juvenile-hormone-related gene (involved in JH biosynthesis, metabolism or signaling).

          (Cheng et al., 2014)

          cDNA identified using the DCABP-23 antibody.

          (Kelly et al., 1997)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (15)
          Reported As
          Symbol Synonym
          CE
          (Nelson et al., 2003)
          CG14904
          (Cheng et al., 2014)
          Cex
          Dcabp-A.2
          (Kelly et al., 1997)
          JHDK
          (Cheng et al., 2014, Maxwell et al., 2002)
          SCP2
          (Toprak et al., 2020, Phillips et al., 2000, Kelly, 1997.7.18)
          Scp2
          (Croset et al., 2018, Gene Disruption Project members, 2018-, Icreverzi et al., 2015, Bischof and FlyORF project members, 2014.6.20, Cordes et al., 2013, Friedman et al., 2011, Barmina et al., 2005)
          ScpX
          (Deolankar et al., 2022)
          cex
          (Nelson et al., 2003)
          dSCP2
          (Nelson et al., 2003, Maxwell et al., 2002)
          Name Synonyms
          Ca2+-sensing low molecular weight GTPase
          Calexcitin
          (Icreverzi et al., 2015, Nelson et al., 2003)
          Cex Ca2+-sensing low molecular weight
          (Quattrone, 1998.9.19)
          Drosophila Ca2+-binding protein A.2
          (Kelly et al., 1997)
          Sarcoplasmic calcium-binding protein 2
          Secondary FlyBase IDs
          • FBgn0025677
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 36 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (36)