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Gene Dmel\Rtc1

General Information
Symbol	Dmel\Rtc1	Species	D. melanogaster
Name	Rtc1	Annotation symbol	CG11130
Feature type	protein_coding_gene	FlyBase ID	FBgn0020909
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	12B10-12C1	Sequence location	X:13,651,210..13,652,631 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rtc1 is referred to in FlyBase by the symbol Dmel\Rtc1 (CG11130, FBgn0020909). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: RNA-3'-phosphate cyclase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: RNA processing; ribosome biogenesis. 2 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: RNA 3'-terminal phosphate cyclase; RNA 3'-terminal phosphate cyclase domain; RNA 3'-terminal phosphate cyclase, insert domain; RNA 3'-terminal phosphate cyclase-like, conserved site; RNA 3'-terminal phosphate cyclase-like, eukaryotic; RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1638146_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rtc1. Gene sequence location is X:13651210..13652631.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA20285 BKN45333 BKN20205 Controlled Vocabulary Terms ribosome biogenesis nucleolus
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12B10-12C1   Limits computationally determined from genome sequence between P{EP}gEP514 and P{EP}EP1354&P{EP}EP790
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rtc1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rtc1-RA FBtr0073820  NM_132691   1303   384
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rtc1-PA   FBpp0073651   42.1   384   8.16     NP_572919   AAF48313
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA 3'-terminal phosphate cyclase (IPR000228) RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (IPR013792) RNA 3'-terminal phosphate cyclase, insert domain (IPR013796) RNA 3'-terminal phosphate cyclase-like, eukaryotic (IPR016443) RNA 3'-terminal phosphate cyclase-like, conserved site (IPR020719) RNA 3'-terminal phosphate cyclase domain (IPR023797)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246457   AA694859   AA697029   AA802132   AA803152   AE014298 AAF48313   AI531728   AW944274   AY058762 AAL13991   BI237966   CO187169   CO262065   CO273649   CO274912   CO298403   CO311213   EC082865   EC202182   EC206319   EC209362   EC211261   EC217849   EC242480   EC251089   EV587585   EV591174   EV591286   EV596311   GH739499   GH740435   GH742445   GH743354   GH743885   GH745521   GH762052   GH764786   GH765339   X04754 CAB55765
UniProtKB/Swiss-Prot	P56175
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0020909    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0020909 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0020909 expression level Developmental Stage   Expression Level embryo 00-02hr    2925 embryo 02-04hr    3397 embryo 04-06hr    2791 embryo 06-08hr    3132 embryo 08-10hr    3379 embryo 10-12hr    3217 embryo 12-14hr    1934 embryo 14-16hr    1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr    2241 embryo 22-24hr    1789 larva L1    2713 larva L2    1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day    1488 adult female 05day    1961 adult female 30day    2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2925) embryo 02-04hr  (3397) embryo 04-06hr  (2791) embryo 06-08hr  (3132) embryo 08-10hr  (3379) embryo 10-12hr  (3217) embryo 12-14hr  (1934) embryo 14-16hr  (1548) embryo 16-18hr  (1269) embryo 18-20hr  (957) embryo 20-22hr  (2241) embryo 22-24hr  (1789) larva L1  (2713) larva L2  (1408) larva L3 12hr old  (946) larva L3 puffstage 1-2  (530) larva L3 puffstage 3-6  (656) larva L3 puffstage 7-9  (679) white prepupae new  (627) white prepupae 12hr  (625) white prepupae 24hr  (671) pupae 2d postWPP  (626) pupae 3d postWPP  (317) pupae 4d postWPP  (401) adult male 01day  (354) adult male 05day  (407) adult male 30day  (392) adult female 01day  (1488) adult female 05day  (1961) adult female 30day  (2006) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2925) embryo 02-04hr  (3397) embryo 04-06hr  (2791) embryo 06-08hr  (3132) embryo 08-10hr  (3379) embryo 10-12hr  (3217) embryo 12-14hr  (1934) embryo 14-16hr  (1548) embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr  (2241) embryo 22-24hr  (1789) larva L1  (2713) larva L2  1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day  1488 adult female 05day  (1961) adult female 30day  (2006) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2925 embryo 02-04hr    3397 embryo 04-06hr    2791 embryo 06-08hr    3132 embryo 08-10hr    3379 embryo 10-12hr    3217 embryo 12-14hr    1934 embryo 14-16hr    1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr    2241 embryo 22-24hr    1789 larva L1    2713 larva L2    1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day    1488 adult female 05day    1961 adult female 30day    2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2925 embryo 02-04hr    3397 embryo 04-06hr    2791 embryo 06-08hr    3132 embryo 08-10hr    3379 embryo 10-12hr    3217 embryo 12-14hr    1934 embryo 14-16hr    1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr    2241 embryo 22-24hr    1789 larva L1    2713 larva L2    1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day    1488 adult female 05day    1961 adult female 30day    2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0020909 expression level Developmental Stage   Expression Level embryo 00-02hr    2925 embryo 02-04hr    3397 embryo 04-06hr    2791 embryo 06-08hr    3132 embryo 08-10hr    3379 embryo 10-12hr    3217 embryo 12-14hr    1934 embryo 14-16hr    1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr    2241 embryo 22-24hr    1789 larva L1    2713 larva L2    1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day    1488 adult female 05day    1961 adult female 30day    2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2925) embryo 02-04hr  (3397) embryo 04-06hr  (2791) embryo 06-08hr  (3132) embryo 08-10hr  (3379) embryo 10-12hr  (3217) embryo 12-14hr  (1934) embryo 14-16hr  (1548) embryo 16-18hr  (1269) embryo 18-20hr  (957) embryo 20-22hr  (2241) embryo 22-24hr  (1789) larva L1  (2713) larva L2  (1408) larva L3 12hr old  (946) larva L3 puffstage 1-2  (530) larva L3 puffstage 3-6  (656) larva L3 puffstage 7-9  (679) white prepupae new  (627) white prepupae 12hr  (625) white prepupae 24hr  (671) pupae 2d postWPP  (626) pupae 3d postWPP  (317) pupae 4d postWPP  (401) adult male 01day  (354) adult male 05day  (407) adult male 30day  (392) adult female 01day  (1488) adult female 05day  (1961) adult female 30day  (2006) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2925) embryo 02-04hr  (3397) embryo 04-06hr  (2791) embryo 06-08hr  (3132) embryo 08-10hr  (3379) embryo 10-12hr  (3217) embryo 12-14hr  1934 embryo 14-16hr  1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr  2241 embryo 22-24hr  1789 larva L1  (2713) larva L2  1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day  1488 adult female 05day  1961 adult female 30day  2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2925 embryo 02-04hr    3397 embryo 04-06hr    2791 embryo 06-08hr    3132 embryo 08-10hr    3379 embryo 10-12hr    3217 embryo 12-14hr    1934 embryo 14-16hr    1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr    2241 embryo 22-24hr    1789 larva L1    2713 larva L2    1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day    1488 adult female 05day    1961 adult female 30day    2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2925 embryo 02-04hr    3397 embryo 04-06hr    2791 embryo 06-08hr    3132 embryo 08-10hr    3379 embryo 10-12hr    3217 embryo 12-14hr    1934 embryo 14-16hr    1548 embryo 16-18hr    1269 embryo 18-20hr    957 embryo 20-22hr    2241 embryo 22-24hr    1789 larva L1    2713 larva L2    1408 larva L3 12hr old    946 larva L3 puffstage 1-2    530 larva L3 puffstage 3-6    656 larva L3 puffstage 7-9    679 white prepupae new    627 white prepupae 12hr    625 white prepupae 24hr    671 pupae 2d postWPP    626 pupae 3d postWPP    317 pupae 4d postWPP    401 adult male 01day    354 adult male 05day    407 adult male 30day    392 adult female 01day    1488 adult female 05day    1961 adult female 30day    2006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0020909    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0020909 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0020909 expression level Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0020909 expression level Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    149.575 Larval Midgut    65.2 Larval Hindgut    80.2 Larval Malpighian Tubules    44.2 Larval Fat Body    49.7 Larval Salivary Gland    115.4 Larval Trachea    154.75 Larval Carcass    94.75 Adult Head    74.4 Adult Eye    45.875 Adult Brain    66.3 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    99 Adult Midgut    80.5 Adult Hindgut    83.5 Adult Malpighian Tubules    80.6 Adult Fat Body    93.2 Adult Salivary Gland    89.1 Adult Heart    55.45 Adult VirginFemale Spermatheca    61.9 Adult InseminatedFemale Spermatheca    81 Adult Ovary    252.2 Adult Testis    41.4 Adult Male Accessory Gland    96.7 Adult Carcass    83.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    74.4   NA  Eye    45.875   NA  Brain    66.3   149.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    67.3   NA  Crop    99   65.2  Midgut    80.5   80.2  Hindgut    83.5   44.2  Malpighian Tubules    80.6   49.7  Fat Body    93.2   115.4  Salivary Gland    89.1   NA  Heart    55.45   154.75  Trachea    NA   NA  VirginFemale Spermatheca    61.9   NA  InseminatedFemale Spermatheca    81   NA  Ovary    252.2   NA  Testis    41.4   NA  Male Accessory Gland    96.7   94.75  Carcass    83.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020909 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11130-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Rtc1GD7208 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Rtc1GD7208 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Rtc1GD7208 trichogen cell, with Scer\GAL4pnr-MD237 Rtc1GD7208
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Rtc1 Class Mutagen Stocks Known lesion Rtc1G817 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rtc1 Class Mutagen Stocks Known lesion Rtc1GD7208 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6247 (Ryder, 2004.4.26)
Duplicated in	Dp(1;3)DC274 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7208} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Rtc1G817 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
RNA-3'-phosphate cyclase activity inferred from sequence or structural similarity with UniProtKB:Q08096 (FlyBase, 1992-)
Biological Process
CV term Evidence References
ribosome biogenesis inferred from electronic annotation with InterPro:IPR016443 (FlyBase Curators et al., 2004-) RNA processing inferred from electronic annotation with InterPro:IPR000228 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleolus inferred from electronic annotation with InterPro:IPR016443 (FlyBase Curators et al., 2004-) nucleus non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rtc1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0020909 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32338
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22603 Dere\GG17810 Dgri\GH12798 Dmoj\GI15953 Dper\GL19868 Dpse\GA10780 Dsec\GM17638 Dsim\GD24814 Dvir\GJ18845 Dwil\GK10124 Dyak\GE17106
Curated drosophilid orthologs	Dpse\GA10780
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001080-PA Aedes aegypti (mosquito) AGAP010498-PA Anopheles gambiae (mosquito) XP_001945525.1 Acyrthosiphon pisum (pea aphid) At5g22100.1 Arabidopsis thaliana (wall cress) 8631 Batrachochytrium dendrobatidis (chytrid fungus) 114924 Branchiostoma floridae (lancelet) 274592 Branchiostoma floridae (lancelet) XP_001893478.1 Brugia malayi (roundworm nematode) BGIBMGA009849-PA Bombyx mori (silk worm) ENSBTAP00000024840 Bos taurus (bovine) CAL0001795 Candida albicans (a form of yeast) CN21640 Caenorhabditis brenneri (small nematode) CBP17086 Caenorhabditis briggsae (nematode) CE32083 Caenorhabditis elegans (worm) ENSCAFP00000003072 Canis familiaris (dog) CAGL0E02343g Candida glabrata (haploid yeast) Chro.80423 Cryptosporidium hominis (obligate parasite) JA18564 Caenorhabditis japonica (nematode) CMQ312C Cyanidioschyzon merolae (red alga) cn07150 Cryptococcus neoformans (yeast-like fungus) cgd8_3660 Cryptosporidium parvum (protozoan parasite) CPIJ012313 Culex pipens (mosquito) ENSCPOP00000013839 Cavia porcellus (guinea pig) 138936 Chlamidomonas reinhardtii (green alga) RP04376 Caenorhabditis remanei (nematode) 218453 Capitella spl (polychaete worm) DDB0238227 Dictyostelium discoideum (amoeba) DEHA2F23430g Debaryomyces Hansenii (yeast) 303058 Daphnia pulex (daphnia) ENSDARP00000090911 Danio rerio (zebra fish) ENSECAP00000013757 Equus caballus (horse) XP_649981 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023096 Gymnopilus aculeatus (mushroom) ENSGALP00000024184 Gallus gallus (chicken) GL50803_6590 Giardia lamblia (flagellated protozoan) 115371 Hypsipyla robusta (cedar shoot borer) ENSP00000371169 Homo sapiens (human) KLLA0C05984g Kluyveromyces lactis (yeast) 216688 Lottia gigantea (owl limpet) LmjF35.1700 Leishmania major (virus) 18812 Monocosta brevicollis (choanoflagellate) ENSMODP00000019198 Monodelphis domestica (gray opossum) ENSMMUP00000008837 Macaca mulatta (rhesus monkey) ENSMUSP00000067579 Mus musculus (house mouse) 194731 Nematostella vectensis (starlet anemone) XP_001604756.1 Nasonia vitripennis (wasp) ENSOANP00000020845 Ornithorynchus anatinus (platypus) ENSORLP00000013085 Oryzias latipes (japanese killifish) LOC_Os03g61790.1 Oryza sativa (asian rice) 18113 Ostreococcus tauri (green alga) PF14_0677 Plasmodium falciparum (protozoal parasite) PHUM002380-PA Pediculus humanus (human body louse) PP03304 Pristionchus pacificus (nematode) 106207 Physcomitrella patens (moss) ENSPPYP00000021552 Pongo pygmaeus (orangutan) 71091 Phytophthora ramorum (sudden oak death pathogen) 108412 Phytophthora sojae (root rot pathogen) 650409 Populus trichocarpa (black cottonwood) ENSPTRP00000035488 Pan troglodytes (chimpanzee) PVX_116920 Plasmodium vivax (protozoal parasite) ENSRNOP00000044460 Rattus norvegicus (norway rat) 5051333 Sorghum bicolor (sorghum) YOL010W Saccharomyces cerevisiae (budding yeast) Smp_102450 Schistosoma mansoni (trematode parasite) SPAC12G12.06c Schizosaccharomyces pombe (fission yeast) XP_797204.2 Strongylocentrotus purpuratus (purple sea urchin) 21493 Trichoplax adhaerens (metazoa) TA03460 Theileria annulata (apicomplexan parasite) XP_967971.1 Tribolium castaneum (red flour beetle) Tc00.1047053510761.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016197 Tetraodon nigroviridis (green spotted pufferfish) TP03_0231 Theileria parva (parasitic protozoan) 29705 Thalassiosira pseudonana (marine diatom) ENSTRUP00000026468 Takifugu rubripes (pufferfish Takifugu) 7.m00396 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000001308 Xenopus tropicalis (frog) YALI0A05555g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15598 NV15100 LH24768 ISCW015647 FBgn0234587 FBgn0212139 FBgn0205991 FBgn0196134 FBgn0172546 JGI_V11_303058 FBgn0070836 FBgn0157466 FBgn0138702 FBgn0120277 FBgn0110031 FBgn0099597 CPIJ012313 BGIBMGA009849 ACYPI007470 GB12601 AGAP010498 AAEL001080 PHUM613900 GLEAN_02529
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	26606 w* P{EP}Rtc1G817/FM6, w*
VDRC	v18145 w1118; P{GD7208}v18145/TM3
Genomic Clones ( 1 )
	BACR11H20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 34 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD02972
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM01682 GM03904 GM08959 GM10315 LD05354 RE34311
Other clones	11103 53633 100972 274824 CK01.24B.D5 CK01.30D.D6 CK01.99C.D7 CK01.142C.E11 Dmel_neb_013996_0203_0777 Dmel_neb_015246_0324_3372 Dmel_neb_015532_0318_2744 Dmel_neb_015973_0907_1545 EK026847 EK084316 EK111735 EK115918 EK172920 EK223749 RP001005057 RP001013932 RP001015440 RP001021505 RP001026467 RP001026891 RP001033150 RP001034032 RP001039892
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0020909 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32338
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132691 RefSeq (Proteins) • NP_572919 DDBJ / EMBL / GenBank • AAF48313 AAL13991 AI531728 AW944274 AY058762 CAB55765 M15898 X04754 Entrez Gene - A searchable database of RefSeq genes. • 32338 UniProtKB/Swiss-Prot • P56175
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA 3'-terminal phosphate cyclase (IPR000228) RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (IPR013792) RNA 3'-terminal phosphate cyclase, insert domain (IPR013796) RNA 3'-terminal phosphate cyclase-like, eukaryotic (IPR016443) RNA 3'-terminal phosphate cyclase-like, conserved site (IPR020719) RNA 3'-terminal phosphate cyclase domain (IPR023797)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0020909 DRSC - Results from RNAi screens. • FBgn0020909 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020909 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11130-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0020909 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32338 InParanoid A subset of ortholog calls from InParanoid. • AAEL001080-PA Aedes aegypti (mosquito) AGAP010498-PA Anopheles gambiae (mosquito) XP_001945525.1 Acyrthosiphon pisum (pea aphid) At5g22100.1 Arabidopsis thaliana (wall cress) 8631 Batrachochytrium dendrobatidis (chytrid fungus) 114924 Branchiostoma floridae (lancelet) 274592 Branchiostoma floridae (lancelet) XP_001893478.1 Brugia malayi (roundworm nematode) BGIBMGA009849-PA Bombyx mori (silk worm) ENSBTAP00000024840 Bos taurus (bovine) CAL0001795 Candida albicans (a form of yeast) CN21640 Caenorhabditis brenneri (small nematode) CBP17086 Caenorhabditis briggsae (nematode) CE32083 Caenorhabditis elegans (worm) ENSCAFP00000003072 Canis familiaris (dog) CAGL0E02343g Candida glabrata (haploid yeast) Chro.80423 Cryptosporidium hominis (obligate parasite) JA18564 Caenorhabditis japonica (nematode) CMQ312C Cyanidioschyzon merolae (red alga) cn07150 Cryptococcus neoformans (yeast-like fungus) cgd8_3660 Cryptosporidium parvum (protozoan parasite) CPIJ012313 Culex pipens (mosquito) ENSCPOP00000013839 Cavia porcellus (guinea pig) 138936 Chlamidomonas reinhardtii (green alga) RP04376 Caenorhabditis remanei (nematode) 218453 Capitella spl (polychaete worm) DDB0238227 Dictyostelium discoideum (amoeba) DEHA2F23430g Debaryomyces Hansenii (yeast) 303058 Daphnia pulex (daphnia) ENSDARP00000090911 Danio rerio (zebra fish) ENSECAP00000013757 Equus caballus (horse) XP_649981 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023096 Gymnopilus aculeatus (mushroom) ENSGALP00000024184 Gallus gallus (chicken) GL50803_6590 Giardia lamblia (flagellated protozoan) 115371 Hypsipyla robusta (cedar shoot borer) ENSP00000371169 Homo sapiens (human) KLLA0C05984g Kluyveromyces lactis (yeast) 216688 Lottia gigantea (owl limpet) LmjF35.1700 Leishmania major (virus) 18812 Monocosta brevicollis (choanoflagellate) ENSMODP00000019198 Monodelphis domestica (gray opossum) ENSMMUP00000008837 Macaca mulatta (rhesus monkey) ENSMUSP00000067579 Mus musculus (house mouse) 194731 Nematostella vectensis (starlet anemone) XP_001604756.1 Nasonia vitripennis (wasp) ENSOANP00000020845 Ornithorynchus anatinus (platypus) ENSORLP00000013085 Oryzias latipes (japanese killifish) LOC_Os03g61790.1 Oryza sativa (asian rice) 18113 Ostreococcus tauri (green alga) PF14_0677 Plasmodium falciparum (protozoal parasite) PHUM002380-PA Pediculus humanus (human body louse) PP03304 Pristionchus pacificus (nematode) 106207 Physcomitrella patens (moss) ENSPPYP00000021552 Pongo pygmaeus (orangutan) 71091 Phytophthora ramorum (sudden oak death pathogen) 108412 Phytophthora sojae (root rot pathogen) 650409 Populus trichocarpa (black cottonwood) ENSPTRP00000035488 Pan troglodytes (chimpanzee) PVX_116920 Plasmodium vivax (protozoal parasite) ENSRNOP00000044460 Rattus norvegicus (norway rat) 5051333 Sorghum bicolor (sorghum) YOL010W Saccharomyces cerevisiae (budding yeast) Smp_102450 Schistosoma mansoni (trematode parasite) SPAC12G12.06c Schizosaccharomyces pombe (fission yeast) XP_797204.2 Strongylocentrotus purpuratus (purple sea urchin) 21493 Trichoplax adhaerens (metazoa) TA03460 Theileria annulata (apicomplexan parasite) XP_967971.1 Tribolium castaneum (red flour beetle) Tc00.1047053510761.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016197 Tetraodon nigroviridis (green spotted pufferfish) TP03_0231 Theileria parva (parasitic protozoan) 29705 Thalassiosira pseudonana (marine diatom) ENSTRUP00000026468 Takifugu rubripes (pufferfish Takifugu) 7.m00396 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000001308 Xenopus tropicalis (frog) YALI0A05555g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32338 modMine - Data generated by the modENCODE project. • FBgn0020909 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15598 NV15100 LH24768 ISCW015647 FBgn0234587 FBgn0212139 FBgn0205991 FBgn0196134 FBgn0172546 JGI_V11_303058 FBgn0070836 FBgn0157466 FBgn0138702 FBgn0120277 FBgn0110031 FBgn0099597 CPIJ012313 BGIBMGA009849 ACYPI007470 GB12601 AGAP010498 AAEL001080 PHUM613900 GLEAN_02529
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG11130   Rtc1 (Doumanis et al., 2009, Popodi et al., 2010-)
Name Synonym	Rtc1
Secondary FlyBase IDs
References ( 15 )
Research paper	Doumanis et al., 2009, PLoS ONE 4(9): e7275 RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. [FBrf0209128] Yan et al., 1987, Nucleic Acids Res. 15: 67--85 Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster. [FBrf0047113]
Supplementary material	Khanna et al., 2010, BMC Genomics 11(1): Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210978] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Popodi et al., 2010-, Small X duplications for the stock center collection. Small X duplications for the stock center collection. [FBrf0210621] Bellen, 2009.2.6, BDGP_2009_0206.GenExel.xml BDGP_2009_0206.GenExel.xml [FBrf0206623] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Yan, 1999.9.13, GenBank/EMBL/DDBJ: X04754 Drosophila yolk polypeptide gene YP3. [FBrf0122265]
Protein sequence record	Swiss-Prot Project Members, 1997.2.1, UniProtKB: P56175 PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (EC 6.5.1.4) (RNA-3'- PHOSPHATE CYCLASE) (RNA CYCLASE) (FRAGMENT). [FBrf0124133]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]