FB2022_03, released June 9, 2022

Gene: Dmel\scu

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General Information
Symbol
Dmel\scu
Species
D. melanogaster
Name
scully
Annotation Symbol
CG7113
Feature Type
protein_coding_gene
FlyBase ID
FBgn0021765
Gene Model Status
Current
Stock Availability
14 publicly available
Enzyme Name (EC)
7-beta-hydroxysteroid dehydrogenase (NADP(+)) (1.1.1.201)
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)) (1.1.1.239)
Acetoacetyl-CoA reductase (1.1.1.36)
17-beta-estradiol 17-dehydrogenase (1.1.1.62)
Gene Summary
scully (scu) encodes a mitochondrial protein that is part of a three protein complex responsible for cleaving the 5'-end of mitochondrial tRNAs. scu product forms a sub-complex with the protein encoded by rswl. This sub-complex binds the tRNA and recruits the metallonuclease encoded by mldr, which is responsible for cleaving the phosphodiester backbone of the RNA. Loss of scu results in lethality and aberrantly processed mtDNA transcripts. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)
All Summaries
Also Known As

HL-X

Key Links
Genomic Location
Cytogenetic map
16F6-16F6
Sequence location
Recombination map
1-59
RefSeq locus
NC_004354 REGION:18091259..18092853
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
inferred from direct assay
(Shafqat et al., 2003)
enables acetoacetyl-CoA reductase activity
inferred from direct assay
(Shafqat et al., 2003)
enables estradiol 17-beta-dehydrogenase activity
inferred from direct assay
(Shafqat et al., 2003)
enables steroid dehydrogenase activity
inferred from direct assay
(Shafqat et al., 2003)
enables testosterone dehydrogenase (NAD+) activity
inferred from direct assay
(Shafqat et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables estradiol 17-beta-dehydrogenase activity
inferred from biological aspect of ancestor with PANTHER:PTN001213039
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in acyl-CoA metabolic process
inferred from direct assay
(Shafqat et al., 2003)
involved_in androgen metabolic process
inferred from direct assay
(Shafqat et al., 2003)
involved_in ecdysone metabolic process
inferred from direct assay
(Shafqat et al., 2003)
involved_in estrogen metabolic process
inferred from direct assay
(Shafqat et al., 2003)
involved_in fatty acid metabolic process
inferred from direct assay
(Shafqat et al., 2003)
involved_in mitochondrial tRNA processing
inferred from mutant phenotype
(Sen et al., 2016)
involved_in steroid metabolic process
inferred from direct assay
(Shafqat et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in androgen metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001213039
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in estrogen metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001213039
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001213039
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of mitochondrial ribonuclease P complex
inferred from direct assay
(Sen et al., 2016)
located_in mitochondrion
inferred from direct assay
(Sen et al., 2016)
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN001213039
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in mitochondrion
inferred from sequence or structural similarity with UniProtKB:O08756
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the short-chain dehydrogenases/reductases (SDR) family. (O18404)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
A 7-beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH (1.1.1.201)
Testosterone + NAD(+) = androstenedione + NADH (1.1.1.239)
(R)-3-hydroxyacyl-CoA + NADP(+) = 3-oxoacyl-CoA + NADPH (1.1.1.36)
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H (1.1.1.62)
Predictions / Assertions
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H (1.1.1.62)
Summaries
Gene Snapshot
scully (scu) encodes a mitochondrial protein that is part of a three protein complex responsible for cleaving the 5'-end of mitochondrial tRNAs. scu product forms a sub-complex with the protein encoded by rswl. This sub-complex binds the tRNA and recruits the metallonuclease encoded by mldr, which is responsible for cleaving the phosphodiester backbone of the RNA. Loss of scu results in lethality and aberrantly processed mtDNA transcripts. [Date last reviewed: 2018-10-04]
Gene Group (FlyBase)
CH-OH STEROID DEHYDROGENASES -
Steroid dehydrogenases are NAD or NADP dependent oxidoreductases with steroid as a substrate. Most members of the family contain the tyrosine and lysine of the catalytic triad in a YxxxK sequence. (Adapted from PMID:10668397).
MITOCHONDRIAL RNASE P COMPLEX -
Mitochondrial ribonuclease P is a eukaryotic-specific, protein-only enzyme that catalyzes 5' end maturation of mitochondrial precursor transfer RNAs. It comprises 3 subunits (none of which are homologous to the RNA-based RNase P proteins): a tRNA methyltransferase, a short-chain dehydrogenase/reductase, and a metallonuclease, which houses the RNase P active site. (Adapted from PMID:27187488.)
Protein Function (UniProtKB)
Versatile enzyme presenting two types of activity; L-3-hydroxyacyl-CoA dehydrogenase ((3S)-3-hydroxyacyl-CoA dehydrogenase) activity and hydroxysteroid dehydrogenase (HSD) activity with a wide substrate spectrum. As a (3S)-3-hydroxyacyl-CoA dehydrogenase, it functions in the third step of the fatty acid beta-oxidation pathway, a major metabolic process in which fatty acids are oxidized to provide a significant source of energy, while also generating acyl-CoA metabolites used by many metabolic routes (PubMed:12917011) (Probable). As a HSD, it functions in the degradation pathways of glucocorticoids and sex steroids and epimerization of bile acids; catalyzes the beta-oxidation at position 17 of androgens and estrogens, has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone, and carries out oxidative conversions of 7-beta-hydroxylated bile acids like ursodeoxycholate or isoursodeoxycholate (also known as 3-beta,7-beta-dihydroxy-5-beta-cholan-24-oate or 7-beta-hydroxyisolithocholate, respectively). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). Required for cell survival during embryonic development. May play a role in germline formation (PubMed:9585418, PubMed:12917011).
(UniProt, O18404)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(1)16Fd
Major lethal phase in early pupae. Somatic mosaics in the adult hypoderm show fewer and smaller bristles and smooth ommatidia. Lethal in germ-line mosaics.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\scu for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18404)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.39

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
scu-RA
FBtr0074511
NM_078672
1034
255
scu-RB
FBtr0308351
NM_001258800
1134
126
Additional Transcript Data and Comments
Reported size (kB)

1.0 (northern blot)

(Torroja et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
scu-PA
FBpp0074285
26.9
255
9.52
O18404
NP_523396
AAF48797
scu-PB
FBpp0300670
13.4
126
7.36
D5A7S2
NP_001245729
AFH07442
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

255 (aa); 27 (kD predicted)

(Torroja et al., 1998)
Comments
External Data
Subunit Structure (UniProtKB)

Multimer.

(UniProt, O18404)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scu using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
primordial germ cell
(Fisher et al., 2012)
embryonic stage 11 -- 12
germline cell
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic midgut chamber
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
late embryonic stage
gonad | precursor
(Torroja et al., 1998)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Torroja et al., 1998)
larval stage
gonad
(Torroja et al., 1998)
third instar larval stage
epithelial cell of midgut
(Torroja et al., 1998)
embryonic/larval central nervous system
(Torroja et al., 1998)
embryonic/larval salivary gland
(Torroja et al., 1998)
imaginal disc
(Torroja et al., 1998)
Malpighian tubule
(Torroja et al., 1998)
adult stage | female
(Torroja et al., 1998)
adult stage | male
(Torroja et al., 1998)
Additional Descriptive Data

scu transcripts are detected in all stages tested (embryos and adult males and females). In late embryos, strong expression is observed in the gonadal primordia and the expression persists through the larval stages. Larval expression is also observed in the imaginal discs, CNS, and salivary glands. Weaker expression is observed in gut epithelial cells and in Malpighian tubules. In adults, high transcript levels were observed in ovaries within the nurse cells and in testes.

(Torroja et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of mitochondrial ribonuclease P complex
inferred from direct assay
(Sen et al., 2016)
located_in mitochondrion
inferred from direct assay
(Sen et al., 2016)
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\scu in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of scu
Transgenic constructs containing regulatory region of scu
Aberrations (Deficiencies and Duplications) ( 3 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die before end of P-stage
lethal - all die before end of P-stage, with Scer\GAL4Act5C.PI
lethal - all die before end of P-stage, with Scer\GAL4αTub84B.PL
lethal - all die before end of P-stage | recessive
lethal - all die before end of pupal stage | recessive
partially lethal - majority die, with Scer\GAL4Act5C.PI
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal developmental rate
abnormal neurophysiology | germline clone
some die during embryonic stage
some die during pupal stage
some die during pupal stage | recessive
wild-type
Phenotype manifest in
Allele
embryonic/larval brain | larval stage
eye photoreceptor cell & mitochondrion | somatic clone
eye photoreceptor cell | somatic clone
female germline stem cell | germline clone
larval neuroblast
mitochondrion | larval stage
neuroblast | larval stage
ommatidium | somatic clone
pupal spiracle
rhabdomere | somatic clone
spermatocyte
spermatocyte & mitochondrion
spermatocyte & nucleolus
testis
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HSD17B10
15 of 15
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hsd17b10
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Hsd17b10
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\hsd17b10
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\hsd17b10
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ard-1
14 of 15
Yes
Yes
Cele\C06E4.3
2 of 15
No
No
Cele\dhs-11
1 of 15
No
No
Cele\F02C12.2
1 of 15
No
No
Cele\F26D2.15
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (23)
Atha\AT3G26770
5 of 9
Yes
Yes
Atha\AT2G47120
4 of 9
No
Yes
Atha\AT3G26760
4 of 9
No
Yes
Atha\ABA2
3 of 9
No
Yes
Atha\AT3G29260
3 of 9
No
Yes
Atha\AT4G03140
3 of 9
No
Yes
Atha\ATA1
3 of 9
No
Yes
Atha\SDR2
3 of 9
No
Yes
Atha\SDR4
3 of 9
No
Yes
Atha\AT2G29340
2 of 9
No
Yes
Atha\SDR3
2 of 9
No
Yes
Atha\AT1G24360
1 of 9
No
No
Atha\AT1G62610
1 of 9
No
No
Atha\AT1G63380
1 of 9
No
No
Atha\AT2G29150
1 of 9
No
No
Atha\AT2G29310
1 of 9
No
No
Atha\AT2G30670
1 of 9
No
Yes
Atha\AT3G46170
1 of 9
No
No
Atha\AT3G55290
1 of 9
No
No
Atha\AT3G55310
1 of 9
No
No
Atha\AT5G06060
1 of 9
No
No
Atha\AT5G18210
1 of 9
No
No
Atha\SDR5
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\YDL114W
2 of 15
Yes
No
Scer\AYR1
1 of 15
No
No
Scer\IRC24
1 of 15
No
No
Scer\TDA5
1 of 15
No
No
Scer\YIR035C
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPAC4H3.08
1 of 12
Yes
No
Spom\SPAC8E11.10
1 of 12
Yes
Yes
Spom\SPAC922.06
1 of 12
Yes
No
Spom\SPBC30D10.05c
1 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (22)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG2070
1 of 10
CG3603
1 of 10
CG3842
1 of 10
CG6012
1 of 10
CG8888
1 of 10
CG9265
1 of 10
CG13284
1 of 10
CG13833
1 of 10
CG15629
1 of 10
CG17121
1 of 10
CG30491
1 of 10
CG30495
1 of 10
CG31809
1 of 10
CG31810
1 of 10
firl
1 of 10
Ldsdh1
1 of 10
Mfe2
1 of 10
naz
1 of 10
Rdh1
1 of 10
spidey
1 of 10
sro
1 of 10
Wwox
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HSD17B10; hydroxysteroid 17-beta dehydrogenase 10
    15 of 15
    300256
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    scu - Akap200
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Akr1B
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Ald1
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - AnxB10
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Bacc
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG10638
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG11267
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG14715
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG2852
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG5174
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG5355
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - CG8036
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Calr
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Chd64
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Cndp2
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Cog3
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Df31
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Eb1
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - EndoGI
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Eno
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Fim
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Fkbp12
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Fkbp14
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - GstE6
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - GstO3
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - GstT1
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - HINT1
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Inos
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Mdh2
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Moe
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Nacα
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Nlp
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Ntf-2
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - PCNA
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - PHGPx
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Pdi
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Pgk
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Pglym78
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Prosβ5
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Prx2540-2
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Rab11
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - RhoGDI
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Sh3β
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Stip1
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Sumo
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Trx-2
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - Uch
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - awd
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - capt
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - chic
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - cib
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - eEF5
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - fabp
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - loqs
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - mldr
    anti tag coimmunoprecipitation, anti tag western blot
    (Sen et al., 2016)
    scu - regucalcin
    experimental knowledge based
    (Guruharsha et al., 2011)
    scu - rswl
    anti tag coimmunoprecipitation, anti tag western blot
    (Sen et al., 2016)
    scu - yip2
    experimental knowledge based
    (Guruharsha et al., 2011)
    RNA-protein
    Physical Interaction
    Assay
    References
    scu - PQBP1
    anti bait coimmunoprecipitation, primer specific pcr
    (Wan et al., 2015)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Multimer.
    (UniProt, O18404 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-59
    Cytogenetic map
    16F6-16F6
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    16F6-16F6
    Limits computationally determined from genome sequence between P{EP}EP970 and P{EP}ari-1EP317
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    16E-17A
    (Ortuno-Sahagun, 1997.10.13)
    Experimentally Determined Recombination Data
    Location

    1-59

    (FlyBase, 2016)

    1-58.9

    (Comeron et al., 2012)
    Left of (cM)
    (Torroja et al., 1998)
    Right of (cM)
    (Torroja et al., 1998)
    Notes

    Mapped by recombination and segmental aneuploidy to the interval between Sh and wupA.

    (Torroja et al., 1998)
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (10)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (117)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Saoji et al., 2021)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    Candidate gene for cyst presence/absence quantitative trait locus.

    (Macdonald and Goldstein, 1999)

    Analysis of scu mutants suggests a role for scu in germline formation.

    (Torroja et al., 1998)

    Mutation analysis of scu suggests scu is required for nervous system development and required in mature neurons.

    (de la Pompa, 1994)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 51 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL - MARRVEL (model organism gene)
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (15)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    References (91)