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Gene Dmel\Tor

General Information
Symbol	Dmel\Tor	Species	D. melanogaster
Name	Target of rapamycin	Annotation symbol	CG5092
Feature type	protein_coding_gene	FlyBase ID	FBgn0021796
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	dTOR, mTOR, FRAP/TOR
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34A4-34A4	Sequence location	2L:13,004,480..13,013,197 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Target of rapamycin is referred to in FlyBase by the symbol Dmel\Tor (CG5092, FBgn0021796). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein self-association. There is experimental evidence for 15 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; single-organism developmental process; growth; response to DNA damage stimulus; positive regulation of ribosome biogenesis; endocytic recycling; energy taxis; determination of adult lifespan; neuron differentiation. 40 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organelle; cytoplasmic part; anatomical structure; organ system subdivision; intracellular organelle; portion of tissue; salivary gland imaginal ring; embryonic/larval fat body; cell part; nucleus; cell cycle; external compound sense organ; adult segment; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; Domain of unknown function DUF3385, target of rapamycin protein; PIK-related kinase; PIK-related kinase, FAT; PIK-related kinase, FATC; Phosphatidylinositol 3-/4-kinase, catalytic domain; Phosphatidylinositol 3/4-kinase, conserved site; Protein kinase-like domain; Rapamycin-binding domain; Serine/threonine-protein kinase TOR/Smg1; Tetratricopeptide repeat; Tetratricopeptide repeat-containing domain; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641510_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tor. Gene sequence location is 2L:13004480..13013197.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34A4-34A4   Limits computationally determined from genome sequence between P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639 and P{lacW}l(2)k11328k11328&P{lacW}l(2)k10105k10105
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34A3-34A4   (determined by in situ hybridisation)   (Spradling et al., 1999) 34A3-34A4     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tor for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tor-RA FBtr0080422  NM_080152   7984   2470 Tor-RB FBtr0336615  NM_001273498   7987   2471
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tor-PA   FBpp0080003   281.0   2470   6.91     NP_524891   AAF53237 Tor-PB   FBpp0307598   281.2   2471   6.91     NP_001260427   AGB92962
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidylinositol 3/4-kinase, conserved site (IPR018936) Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403) PIK-related kinase, FAT (IPR003151) PIK-related kinase, FATC (IPR003152) Rapamycin-binding domain (IPR009076) Protein kinase-like domain (IPR011009) Armadillo-like helical (IPR011989) Tetratricopeptide repeat-containing domain (IPR013026) PIK-related kinase (IPR014009) Armadillo-type fold (IPR016024) Tetratricopeptide repeat (IPR019734) Domain of unknown function DUF3385, target of rapamycin protein (IPR024585) Serine/threonine-protein kinase TOR/Smg1 (IPR026683) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803234   AE014134 AAF53237   AE014134 AGB92962   AI403196   AI531294   AQ026123   AQ073518   AW941350   AW944227   AY052068 AAK93492   AY069275 AAL39420   BI228418   CO186204   CO269181   CO329991   CO343609   CZ483284   EC051706   EC051710   EC054209   EC056021   EC059091   EC194499   EC216264   EC250865   EC253768   EW712647   EW712688   EY198877
UniProtKB/Swiss-Prot	Q9VK45
UniProtKB/TrEMBL	Q8T9I6 Q960H0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    260.25 Larval Midgut    105 Larval Hindgut    116.9 Larval Malpighian Tubules    135.6 Larval Fat Body    200.2 Larval Salivary Gland    206.5 Larval Trachea    194.9 Larval Carcass    124.05 Adult Head    101.8 Adult Eye    129.05 Adult Brain    151.7 Adult Thoracic-Abdominal Ganglion    150.6 Adult Crop    184 Adult Midgut    116.6 Adult Hindgut    238.8 Adult Malpighian Tubules    153.6 Adult Fat Body    110.7 Adult Salivary Gland    166.7 Adult Heart    167.625 Adult VirginFemale Spermatheca    215.6 Adult InseminatedFemale Spermatheca    247.6 Adult Ovary    273.7 Adult Testis    40.1 Adult Male Accessory Gland    76 Adult Carcass    139.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    101.8   NA  Eye    129.05   NA  Brain    151.7   260.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    150.6   NA  Crop    184   105  Midgut    116.6   116.9  Hindgut    238.8   135.6  Malpighian Tubules    153.6   200.2  Fat Body    110.7   206.5  Salivary Gland    166.7   NA  Heart    167.625   194.9  Trachea    NA   NA  VirginFemale Spermatheca    215.6   NA  InseminatedFemale Spermatheca    247.6   NA  Ovary    273.7   NA  Testis    40.1   NA  Male Accessory Gland    76   124.05  Carcass    139.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    17 ovary, mated 4-day female    14 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    14 embryo 04-06hr    22 embryo 06-08hr    22 embryo 08-10hr    22 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    16 embryo 16-18hr    11 embryo 18-20hr    8 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    13 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    5 adult male 01day    8 adult male 05day    8 adult male 30day    10 adult female 01day    12 adult female 05day    17 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1    29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1  (29) embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1    29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1    29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1    29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1  29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1    29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    13 embryonic 1182-4H    23 embryonic GM2    16 embryonic Kc167    15 embryonic S1    29 embryonic S3    13 leg disc CME L1    15 wing disc CME-W2    13 wing disc ML-DmD8    17 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    8 ovary fGS/OSS    16 ovary OSC    15 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021796 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5092-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Tork17004 lethal, with Scer\GAL4Act5C.PI TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG lethal, with Scer\GAL4ap-md544 TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG lethal, with Scer\GAL4da.G32 TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG lethal, with Scer\GAL4ey.PH TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG lethal (with TorA948V) TorΔP lethal (with TorE161K) TorΔP lethal (with TorG2256D) TorΔP lethal (with TorQ528stop) TorΔP lethal (with TorR97C) TorΔP lethal (with TorR248stop) TorΔP lethal (with TorV2148D) TorΔP lethal (with TorW1251R) TorΔP lethal (with TorΔP) TorA948V TorE161K TorG2256D TorQ528stop TorR97C TorR248stop TorV2148D TorW1251R lethal | larval stage TorΔP lethal | pupal stage | recessive TorA948V TorE161K TorR97C TorW1251R lethal | recessive Tork17004 lethal | recessive | second instar larval stage TorQ528stop TorR248stop TorV2148D lethal | recessive | third instar larval stage TorG2256D Sterility Allele sterile | recessive TorA948V TorE161K TorR97C TorW1251R Other Phenotypes Allele body size defective | second instar larval stage Tork17004 cell size defective TorΔP chemical sensitive | dominant Torunspecified decreased cell number, with Scer\GAL4Bx-MS1096 TorWT.Scer\UAS.T:Zzzz\FLAG decreased cell number, with Scer\GAL4en-e16E TorWT.Scer\UAS.T:Zzzz\FLAG decreased cell number, with Scer\GAL4nub-AC-62 TorTED.Scer\UAS decreased cell number | somatic clone TorΔP decreased cell size Tork17004 decreased cell size, with Scer\GAL4nub-AC-62 TorNIG.5092R TorTED.Scer\UAS decreased cell size | somatic clone Tor2L1 TorΔP decreased cell size | somatic clone, with Scer\GAL4Act5C.PP TorNIG.5092R developmental rate defective TorΔP developmental rate defective, with Scer\GAL4Bx-MS1096 TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG developmental rate defective, with Scer\GAL4en-e16E TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG developmental rate defective, with Scer\GAL4ppl.PP TorTED.Scer\UAS developmental rate defective | recessive TorA948V TorE161K TorR97C TorW1251R gravitaxis defective Tork17004 increased cell death Torey.hs.T:Zzzz\FLAG increased cell death, with Scer\GAL4en.PU TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG increased cell death | recessive TorA948V TorE161K TorR97C TorW1251R increased cell size, with Scer\GAL4en-e16E TorWT.Scer\UAS.T:Zzzz\FLAG long lived, with Scer\GAL4da.G32 TorFRB.Scer\UAS long lived, with Scer\GAL4Lk6-DJ634 TorFRB.Scer\UAS mitotic cell cycle defective | somatic clone TorΔP neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 TorEP2353 neuroanatomy defective | somatic clone TorLL04239 TorΔP size defective, with Scer\GAL4en.PU TorTED.Scer\UAS size defective, with Scer\GAL4ey.PH TorWT.Scer\UAS.T:Zzzz\FLAG size defective, with Scer\GAL4MD-638 TorTED.Scer\UAS size defective, with Scer\GAL4nub-AC-62 TorNIG.5092R TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG small body Tork17004 TorΔP small body, with Scer\GAL4[-]: TorEP2353 small body, with Scer\GAL4en-e16E TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG small body | adult stage | recessive TorA948V TorE161K TorR97C TorW1251R small body | recessive | third instar larval stage Tork17004 visible, with Scer\GAL4Bx-MS1096 TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG visible, with Scer\GAL4en-e16E TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG wild-type Tor+t9.4 wild-type, with Scer\GAL4Act5C.PI TorFRB.Scer\UAS wild-type, with Scer\GAL4ap-md544 TorFRB.Scer\UAS wild-type, with Scer\GAL4Bx-MS1096 TorFRB.Scer\UAS wild-type, with Scer\GAL4en-e16E TorFRB.Scer\UAS wild-type, with Scer\GAL4ey.PH TorFRB.Scer\UAS wild-type, with Scer\GAL4GMR.PF TorFRB.Scer\UAS TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 TorEP2353 autophagic vacuole, with Scer\GAL4GMR.PU TorTED.Scer\UAS autophagic vacuole, with Scer\GAL4Lsp2.PH TorTED.Scer\UAS axon | somatic clone TorLL04239 TorΔP cell cycle TorΔP dendrite | somatic clone TorLL04239 TorΔP dendritic arborizing neuron | somatic clone TorΔP dorsal mesothoracic disc & nucleolus TorΔP embryonic/larval fat body TorΔP embryonic/larval fat body, with Scer\GAL4ppl.PP TorTED.Scer\UAS TorNIG.5092R embryonic/larval neuroblast Tor2L19 embryonic/larval salivary gland TorΔP eye Torey.hs.T:Zzzz\FLAG eye, with Scer\GAL4ey.PH TorWT.Scer\UAS.T:Zzzz\FLAG eye, with Scer\GAL4GMR.PU TorTED.Scer\UAS eye-antennal disc primordium Torey.hs.T:Zzzz\FLAG eye disc | somatic clone TorΔP fat body TorΔP Tork17004 fat body, with Scer\GAL4Lsp2.PH TorTED.Scer\UAS fat body | second instar larval stage Tork17004 fat body | somatic clone TorΔP fat body | somatic clone, with Scer\GAL4Act5C.PP TorNIG.5092R head | somatic clone Tor2L1 Tor2L19 intersegmental nerve, with Scer\GAL4elav-C155 TorEP2353 larva TorΔP Tork17004 larva, with Scer\GAL4[-]: TorEP2353 larval salivary gland & nucleus (with Tor2L1) Tork17004 larval salivary gland & nucleus (with Tork17004) Tor2L1 lysosome, with Scer\GAL4Lsp2.PH TorTED.Scer\UAS mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP TorWT.Scer\UAS.T:Zzzz\FLAG nucleus Tork17004 ovary TorA948V TorE161K TorR97C TorW1251R salivary gland imaginal ring TorΔP testis TorA948V TorE161K TorR97C TorW1251R vesicle Tork17004 wing, with Scer\GAL4Bx-MS1096 TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG wing, with Scer\GAL4en.PU TorTED.Scer\UAS wing, with Scer\GAL4en-e16E TorWT.Scer\UAS.T:Zzzz\FLAG wing, with Scer\GAL4MD-638 TorTED.Scer\UAS wing, with Scer\GAL4nub-AC-62 TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG TorNIG.5092R wing | posterior, with Scer\GAL4en-e16E TorTED.Scer\UAS TorWT.Scer\UAS.T:Zzzz\FLAG
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of Tor Class Mutagen Stocks Known lesion Tork17004 P-element activity 2 Yes Torf00113 1 -- Torf00799 piggyBac transposase 1 -- TorLL04239 piggyBac transposase 1 -- TorMB07988 1 -- TorΔP P-element activity 1 Yes Tor15 0 -- Tor2L15 0 -- Tor2L19 ethyl methanesulfonate 0 Yes Tor2L1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Tor2L7 0 -- TorA948V hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes TorE161K hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes TorEP2353 P-element activity 0 Yes TorG2256D hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes TorQ528stop loss of function allele ethyl methanesulfonate 0 Yes TorR248stop loss of function allele ethyl methanesulfonate 0 Yes TorR97C hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Torunspecified 0 -- TorV2148D loss of function allele ethyl methanesulfonate 0 Yes TorW1251R hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes TorΔ6B 0 --
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tor Class Mutagen Stocks Known lesion TorGL00156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TorHMS00904 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TorHMS01114 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TorTED.Scer\UAS antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes TorWT.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Tor+t9.4 in vitro construct - genomic fragment 0 Yes TordsRNA.cGa in vitro construct - RNAi 0 Yes TordsRNA.cSa in vitro construct - RNAi 0 Yes Torey.hs.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TorFRB.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TorGD10721 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TorNIG.5092R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TorRR in vitro construct - amino acid replacement 0 Yes TorRRKD in vitro construct - amino acid replacement 0 Yes TorScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes TorScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TorT:Ivir\HA1 in vitro construct - coding region fusion 0 Yes TorT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)Prl (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)Exel7055 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10721} NA P{TRiP.GL00156} NA P{TRiP.HMS00904} NA P{TRiP.HMS01114} NA P{UAS-Tor.FRB} NA P{UAS-Tor.myc} NA P{UAS-Tor.TED} NA P{UAS-Tor.W} NA P{UAS-Tor.WT} NA heat-shock construct P{ey-TOR.FLAG} NA characterization construct P{dTOR-9.4} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}TorEP2353 NA miscellaneous insertions PBac{SAstopDsRed}LL04239 NA PBac{WH}Torf00113 NA PBac{WH}Torf00799 NA insertion of enhancer trap P{lacW}Tork17004 No insertion of enhancer trap binary system Mi{ET1}TorMB07988 No
Gene Ontology: Function, Process & Cellular Component ( 26 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
protein self-association inferred from direct assay (Zhang et al., 2006)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Rheb (Dimitroff et al., 2012) dendrite morphogenesis inferred from mutant phenotype (Koike-Kumagai et al., 2009) determination of adult lifespan inferred from mutant phenotype (Kapahi et al., 2004) endocytic recycling inferred from direct assay (Hennig et al., 2006) gonad development inferred from mutant phenotype (Zhang et al., 2006) multicellular organism growth inferred from mutant phenotype (Zhang et al., 2006) negative regulation of macroautophagy inferred from mutant phenotype (Scott et al., 2004) phototaxis inferred from genetic interaction with Rheb (Dimitroff et al., 2012) positive regulation of cell size inferred from genetic interaction with gig (Cully et al., 2010) inferred from mutant phenotype (Hall et al., 2007, Cully et al., 2010) positive regulation of protein phosphorylation inferred from genetic interaction with gig (Cully et al., 2010) positive regulation of ribosome biogenesis inferred from mutant phenotype (Hall et al., 2007) regulation of cell growth inferred from direct assay (Hennig et al., 2006) regulation of reactive oxygen species metabolic process inferred from genetic interaction with InR (Lee et al., 2010) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) synaptic growth at neuromuscular junction inferred from genetic interaction with Rheb (Dimitroff et al., 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
drug binding inferred from electronic annotation with InterPro:IPR009076 (FlyBase Curators et al., 2004-) phosphotransferase activity, alcohol group as acceptor inferred from electronic annotation with InterPro:IPR000403, InterPro:IPR018936 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
detection of nutrient traceable author statement (Potter and Xu, 2001) growth traceable author statement (Oldham et al., 2000) phosphorylation non-traceable author statement (Morrison et al., 2000) positive regulation of cell growth non-traceable author statement (Johnston and Gallant, 2002) traceable author statement (Oldham and Hafen, 2003, Bergmann and Lane, 2003) positive regulation of cell size traceable author statement (Potter and Xu, 2001, Jacinto and Hall, 2003) positive regulation of multicellular organism growth traceable author statement (Jacinto and Hall, 2003) positive regulation of organ growth traceable author statement (Potter and Xu, 2001) response to nutrient traceable author statement (Oldham et al., 2000, Jacinto and Hall, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tor - Lst8 anti bait coimmunoprecipitation, anti tag western blot (Wang et al., 2012) Tor - hppy pull down, autoradiography (Resnik-Docampo and de Celis, 2011) Tor - raptor anti bait coimmunoprecipitation, anti tag western blot (Wang et al., 2012)
Other
Interacting group Assay References
Tor - Lst8 anti bait coimmunoprecipitation, anti tag western blot (Wang et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tor allele Gene References Tor2L1 Tsc1 (Radimerski et al., 2002, Gao et al., 2002) TorEP2353 Pten (Oldham et al., 2000) S6k (Zhang et al., 2000) Tork17004 S6k (Zhang et al., 2000) TorTED.Scer\UAS dm (Hennig and Neufeld, 2002) TorWT.Scer\UAS.T:Zzzz\FLAG Pi3K92E (Hennig and Neufeld, 2002) TorΔP Atg1 (Scott et al., 2004) Atg5 (Scott et al., 2004) CycE (Zhang et al., 2000) S6k (Scott et al., 2004) unspecified CG1139 (Goberdhan et al., 2005) foxo (Goberdhan et al., 2005) gig (Zhang et al., 2006) path (Goberdhan et al., 2005) Pi3K92E (Berry and Baehrecke, 2007, Coelho et al., 2005) Ras85D (Berry and Baehrecke, 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70789 DroID - A comprehensive database of gene and protein interactions. • FBgn0021796 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47396 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VK45
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X982D Dipteran inclusive ortholog search EOG60GCZQ Insect inclusive ortholog search EOG65MM14 Arthropod inclusive ortholog search EOG6PC86T Metazoa inclusive ortholog search EOG64BPTW
Orthologs in Drosophila Species (EOG6X982D)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tor     Drosophila simulans   Dsim\GD23862 Y   Drosophila sechellia   Dsec\GM10089     Drosophila erecta   Dere\GG23806 Y   Drosophila yakuba   Dyak\GE18612     Drosophila ananassae   Dana\GF14216 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18654 Y   Drosophila persimilis   Dper\GL24734 Y   Drosophila willistoni   Dwil\GK15310 Y   Drosophila virilis   Dvir\GJ16824 Y   Drosophila mojavensis   Dmoj\GI18090     Drosophila grimshawi   Dgri\GH11387 Y
Orthologs in non-Drosophila Dipterans (EOG60GCZQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000693   Anopheles gambiae Malaria mosquito  Agam\AGAP007873   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004787
Orthologs in non-Dipteran Insects (EOG65MM14)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44905   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010797   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26772   Atta cephalotes Leafcutter ant  Acep\ACEP23536   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18446   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13521   Linepithema humile Argentine ant  Lhum\LH11663   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27240   Solenopsis invicta Red fire ant  Sinv\SINV22769   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004568   Bombyx mori Silkmoth  Bmor\BGIBMGA008924   Bombyx mori Silkmoth  Bmor\BGIBMGA008952   Pediculus humanus Human body louse  Phum\PHUM268820   Tribolium castaneum Red flour beetle  Tcas\TC005546
Orthologs in non-Insect Arthropods (EOG6PC86T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\matK
Orthologs in non-Arthropod Metazoa (EOG64BPTW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\B0261.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006053gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006612gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027361gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006054gn   Danio rerio Zebrafish  Drer\mtor   Xenopus tropicalis Western clawed frog  Xtro\mtor   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000017426   Gallus gallus Domestic chicken  Ggal\MTOR   Mus musculus House mouse  Mmus\Mtor   Rattus norvegicus Norway rat  Rnor\Mtor   Homo sapiens Human  Hsap\MTOR
Human Orthologs (1)
Gene OMIM HGNC Hsap\MTOR
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23862 Drosophila erecta Dere\GG23806 Drosophila ananassae Dana\GF14216 Drosophila pseudoobscura pseudoobscura Dpse\GA18654 Drosophila persimilis Dper\GL24734 Drosophila willistoni Dwil\GK15310 Drosophila virilis Dvir\GJ16824 Drosophila grimshawi Dgri\GH11387
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	7013 y1 w*; P{UAS-Tor.TED}II 25363 w1118; Mi{ET1}TorMB07988 7012 y1 w* P{hsFLP}1; P{UAS-Tor.WT}III 7014 y1 w*; TorΔP P{neoFRT}40A/CyO 11218 y1 w67c23; P{lacW}Tork17004/CyO 35578 y1 sc* v1; P{TRiP.GL00156}attP2 33951 y1 sc* v1; P{TRiP.HMS00904}attP2 34639 y1 sc* v1; P{TRiP.HMS01114}attP2
Harvard	- PBac{WH}Torf00113 - PBac{WH}Torf00799
Kyoto	111369 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}Tork17004 P{neoFRT}40A/CyO y+ 141209 y* w*; PBac{SAstopDsRed}LL04239 P{neoFRT}40A P{FRT(whs)}G13 cn1 bw1/CyO, S* bw1
Genomic Clones ( 2 )
	BACR27F17 BACR48D10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 17 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM10438 SD02269
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22586 RE25959
Other clones	191787 193549 214381.3 CK01.17B.B6 CK01.99A.C5 EC051706 EC051710 EC054209 EC056021 EK016839 EK093807 EK294320 EP17351
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0021796 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47396
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: l(2)k17004 Tor (Oldham et al., 2000)
Source for database merge of	Source for merge of: Tor CG5092 (Zhang et al., 2000)
Additional comments
Other Comments
	Tor is specifically required for developmental axon regrowth but not initial axon outgrowth. (Yaniv et al., 2012) dsRNA made from templates generated with primers directed against this gene results in a reduced mean cell diameter and a corresponding decrease in S6k phosphorylation. Silencing Tor generates a cell-expression profile similar to that of rapamycin-treated cells. (Guertin et al., 2006) dsRNA made from templates generated with primers directed against this gene decreases the level of phosphorylation of both Akt1 and S6k in S2 cells. (Yang et al., 2006) dsRNA made from templates generated with primers directed against this gene used to treat S2 cells. (Yang et al., 2006) Allelic series: TorR248stop = TorQ528stop = TorV2148D > TorG2256D = Tor2L1 > TorR97C = TorE161K = TorA948V = TorW1251R based on the stage of lethality. (Zhang et al., 2006) Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes. (Agaisse et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, a decrease in cell size and a decrease in cytokinetic index is seen. (Bettencourt-Dias et al., 2004) Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body. Tor suppresses autophagy independently of S6k. (Scott et al., 2004) Loss of Tor activity causes induction of autophagy in normally fed animals. (Scott et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080152 NM_001273498 RefSeq (Proteins) • NP_524891 NP_001260427 DDBJ / EMBL / GenBank • AA803234 AAF53237 AAK93492 AAL39420 AGB92962 AI531294 AQ026123 AQ073518 AW941350 AW944227 AY052068 AY069275 CZ483284 Entrez Gene - A searchable database of RefSeq genes. • 47396 UniProtKB/Swiss-Prot • Q9VK45 UniProtKB/TrEMBL • Q8T9I6 Q960H0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidylinositol 3/4-kinase, conserved site (IPR018936) Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403) PIK-related kinase, FAT (IPR003151) PIK-related kinase, FATC (IPR003152) Rapamycin-binding domain (IPR009076) Protein kinase-like domain (IPR011009) Armadillo-like helical (IPR011989) Tetratricopeptide repeat-containing domain (IPR013026) PIK-related kinase (IPR014009) Armadillo-type fold (IPR016024) Tetratricopeptide repeat (IPR019734) Domain of unknown function DUF3385, target of rapamycin protein (IPR024585) Serine/threonine-protein kinase TOR/Smg1 (IPR026683) Tetratricopeptide-like helical (IPR011990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70789 DroID - A comprehensive database of gene and protein interactions. • FBgn0021796 DRSC - Results from RNAi screens. • FBgn0021796 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021796 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5092-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0021796 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47396 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/tor1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47396 modMine - Data generated by the modENCODE project. • FBgn0021796 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VK45
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	5092 (Ravi et al., 2009) CG5092 (Sarbassov et al., 2004, Song et al., 2004, Holloway et al., 2008, Sun et al., 2010, Ni et al., 2010.12.1, Ni et al., 2011.7.19, Derré et al., 2007) CT16317 (Morrison et al., 2000) CT24745 (Morrison et al., 2000) CT24817 (Morrison et al., 2000) DmTOR (Chen et al., 2006) dTOR (Kapahi et al., 2004, Sarbassov et al., 2005, Jorgensen and Tyers, 2004, Sarbassov et al., 2004, Sarbassov et al., 2004, Kapahi et al., 2004, Goraksha and Neufeld, 2005, Ruhf et al., 2004, Buch et al., 2004, Lee and Orr-Weaver, 2003, Oldham et al., 2004, Manning and Cantley, 2003, Bradley and Leevers, 2003, Jacinto and Hall, 2003, Radimerski et al., 2002, Oldham and Hafen, 2003, Marygold and Leevers, 2002, Hennig et al., 2003, Hennig and Neufeld, 2002, Hennig and Neufeld, 2002, Montagne et al., 2002, Radimerski et al., 2002, Kozma and Thomas, 2002, Potter and Xu, 2001, Prober and Edgar, 2001, Gingras et al., 2001, Rhode et al., 2001, Radimerski et al., 2001, Cho et al., 2001, Zhang et al., 2000, Oldham et al., 2000, Oldham et al., 2000, Inoki and Guan, 2006, Wullschleger, 2006, Guertin et al., 2006, Yang et al., 2006, Lasko and Sonenberg, 2007, Miron et al., 2003, Wu et al., 2007, Dekanty et al., 2005, Lizcano et al., 2003, Findlay et al., 2007, Lee et al., 2007, Luong et al., 2006, Mattila et al., 2008, Wang and Huang, 2009, Wessells et al., 2009, Thomson and Johnson, 2010, Dekanty et al., 2010, Bánréti et al., 2012) dTor (Wang et al., 2005, Oldham et al., 2005, Kockel et al., 2005, Radimerski et al., 2002, DiAngelo and Birnbaum, 2006, Song et al., 2008, Read et al., 2009, Cully et al., 2010) dtor (Lee and Orr-Weaver, 2003, Li et al., 2010) FRAP/TOR (Morrison et al., 2000, Morrison et al., 2000) l(2)k17004 (Spradling et al., 1999, ) mTOR (Findlay et al., 2005, McManus and Alessi, 2002) Tor (Martin et al., 2007, Kim and Yoo, 2007, Knox et al., 2007, Blanco et al., 2010, Parisi et al., 2007, Frei et al., 2007, Walker et al., 2006, Friedman and Perrimon, 2006, Teleman et al., 2005, Bateman and McNeill, 2005, Holloway et al., 2008, Mandal et al., 2005, Sun et al., 2010, Song et al., 2008, Hariharan, 2006, Turner et al., 2011, Rehmann et al., 2008, Tang et al., 2011, Harvey et al., 2008, Juhász et al., 2008, Hou et al., 2008, Scott et al., 2007, Patel and Tamanoi, 2006, Chittaranjan et al., 2009, Alvarez-Ponce et al., 2009, Scott et al., 2007, Juhász et al., 2007, Nuzhdin et al., 2009, Bülow et al., 2010, Koike-Kumagai et al., 2009, Sousa-Nunes et al., 2011, Wang and Huang, 2009, Patch et al., 2009, Grewal et al., 2007, Sims et al., 2009, Chen et al., 2006, Robinson et al., 2010, Ballard et al., 2010, Fernández-Ayala et al., 2010, Kim et al., 2010, Zhang et al., 2010, LaFever et al., 2010, Haberman et al., 2010, Cully et al., 2010, Sun et al., 2010, Djiane et al., 2011, Friedman et al., 2011, Zeng et al., 2010, Nisoli et al., 2010, Terashima and Bownes, 2005, Resnik-Docampo and de Celis, 2011, Hsieh et al., 2010, Johnson et al., 2010, Derré et al., 2007, Dimitroff et al., 2012, Tokusumi et al., 2012, Zhang et al., 2012, Kuronen et al., 2009, Pritchett and McCall, 2012, Dar et al., 2012, Chakrabarti et al., 2012, Lindquist et al., 2011) TOR (McNeill et al., 2008, Shingleton, 2005, Teleman et al., 2005, Cygnar et al., 2005, Scott et al., 2004, Scott et al., 2004, Pan et al., 2004, Scott et al., 2005, Grewal et al., 2005, Hay and Sonenberg, 2004, Nijhout, 2003, Tu and Tatar, 2004, Tatar et al., 2004, Stocker et al., 2004, Bergmann and Lane, 2003, Saucedo et al., 2003, Stocker et al., 2003, Scott and Neufeld, 2003, Oldham et al., 2001, Bodmer, 2005, Min et al., 2006, Goraksha and Neufeld, 2006, Edgar, 2006, Wessells et al., 2007, Ballard and Wharton, 2007, Yang et al., 2006, Takacs-Vellai, 2006, Saucedo et al., 2003, Goberdhan et al., 2005, Mosimann et al., 2006, Ruvinsky, 2006, Guertin et al., 2006, Hoshizaki and Gibbs, 2007, Ocorr et al., 2007, Berry and Baehrecke, 2007, Oldham et al., 2008, Leopold and Layalle, 2008, Hennig et al., 2006, Glatter et al., 2011, Lindquist et al., 2011, Layalle et al., 2008, Grewal et al., 2007, Dutta and Baehrecke, 2008, Lee et al., 2008, Hall et al., 2007, Kaplan et al., 2008, Chang and Neufeld, 2009, Yaniv et al., 2012, Lee et al., 2010, Lee et al., 2007, Teleman et al., 2008, Khurana et al., 2006, Ribeiro and Dickson, 2010, Vargas et al., 2010, Zheng and Sehgal, 2010, Bryk et al., 2010, Birse et al., 2010, Boyd et al., 2011, Li et al., 2010, Bjedov et al., 2010, Ferguson et al., 2012, Marshall et al., 2012) tor (Saucedo et al., 2003, Kuronen et al., 2009, Wang et al., 2012, Parrish et al., 2009, Li et al., 2010, Killip and Grewal, 2012) Tor|TOR (Alvarez-Ponce et al., 2012) unnamed (Kraut et al., 2001)
Name Synonym	Target of rapamycin (Martin et al., 2007, Oldham et al., 2000, Yang et al., 2006, Hennig et al., 2006, Patch et al., 2009, Kim et al., 2010, LaFever et al., 2010, Haberman et al., 2010, Terashima and Bownes, 2005) target-of-rapamycin (Davies et al., 2005, Takacs-Vellai, 2006, Marshall et al., 2012) target of rapamycin (Kim and Yoo, 2007, Glatter et al., 2011, Grewal et al., 2007, Harvey et al., 2008, Lee et al., 2010, Dutta and Baehrecke, 2008, Hall et al., 2007, Lee et al., 2007, Koike-Kumagai et al., 2009, Wang et al., 2009, Wessells et al., 2009, Ballard et al., 2010, Ribeiro and Dickson, 2010, Vargas et al., 2010, Cully et al., 2010, Sun et al., 2010, Pritchett and McCall, 2012) Target of Rapamycin (Ballard and Wharton, 2007, Leopold and Layalle, 2008) Target Of Rapamycin (Ocorr et al., 2007) Target-of-rapamycin (Patel and Tamanoi, 2006) target of rapamycin kinase (Khurana et al., 2006)
Secondary FlyBase IDs
	FBgn0032466
References ( 243 )
Generate a list of	All references relating to this gene ( 243 )
List References by type	Research paper  ( 137 ) Supplementary material  ( 9 ) Review  ( 37 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 43 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 32 )
	Adamson and Lajeunesse, 2012, ScientificWorldJournal 2012: 347597 A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. [FBrf0218446] Alvarez-Ponce et al., 2012, Mol. Biol. Evol. 29(1): 123--132 Molecular Population Genetics of the Insulin/TOR Signal Transduction Pathway: A Network-Level Analysis in Drosophila melanogaster. [FBrf0217435] Bánréti et al., 2012, Autophagy 8(4): 623--636 PP2A regulates autophagy in two alternative ways in Drosophila. [FBrf0219207] Chakrabarti et al., 2012, Cell Host Microbe 12(1): 60--70 Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. [FBrf0218984] Dar et al., 2012, Nature 486(7401): 80--84 Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. [FBrf0218587] Defays and Bertoli, 2012, Alcohol 46(8): 737--745 Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. [FBrf0220080] Dimitroff et al., 2012, PLoS ONE 7(2): e30722 Diet and Energy-Sensing Inputs Affect TorC1-Mediated Axon Misrouting but Not TorC2-Directed Synapse Growth in a Drosophila Model of Tuberous Sclerosis. [FBrf0217461] Dragojlovic-Munther and Martinez-Agosto, 2012, Development 139(20): 3752--3763 Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors. [FBrf0219482] Ferguson et al., 2012, J. Cell Sci. 125(6): 1407--1419 Modulation of gurken translation by insulin and TOR signaling in Drosophila. [FBrf0218097] Killip and Grewal, 2012, Dev. Biol. 371(2): 191--202 DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway. [FBrf0219592] Kuo et al., 2012, PLoS Genet. 8(4): e1002684 Insulin signaling mediates sexual attractiveness in Drosophila. [FBrf0218255] Marshall et al., 2012, EMBO J. 31(8): 1916--1930 Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. [FBrf0218035] Penney et al., 2012, Neuron 74(1): 166--178 TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0218076] Poels et al., 2012, Cell Death Differ. 19(10): 1590--1601 Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress. [FBrf0219353] Pritchett and McCall, 2012, Cell Death Differ. 19(6): 1069--1079 Role of the insulin/Tor signaling network in starvation-induced programmed cell death in Drosophila oogenesis. [FBrf0218230] Shim et al., 2012, Nat. Cell Biol. 14(4): 394--400 Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. [FBrf0217918] Straßburger et al., 2012, Dev. Biol. 367(2): 187--196 Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. [FBrf0218526] Thomson et al., 2012, genesis 50(6): 453--465 Oocyte destruction is activated during viral infection. [FBrf0218617] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Wang et al., 2012, Mol. Cell. Biol. 32(12): 2203--2213 LST8 Regulates Cell Growth via Target-of-Rapamycin Complex 2 (TORC2). [FBrf0218417] Yaniv et al., 2012, Curr. Biol. 22(19): 1774--1782 Axon Regrowth during Development and Regeneration Following Injury Share Molecular Mechanisms. [FBrf0219661] Zhang et al., 2012, Cell Death Dis. 3: 266 The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome. [FBrf0217356] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Glatter et al., 2011, Mol. Syst. Biol. 7: 547 Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. [FBrf0216604] Lindquist et al., 2011, Genome Res. 21(3): 433--446 Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Tang et al., 2011, PLoS Genet. 7(11): e1002373 FOXO Regulates Organ-Specific Phenotypic Plasticity In Drosophila. [FBrf0216701] Turner et al., 2011, PLoS Genet. 7(3): e1001336 Population-Based Resequencing of Experimentally Evolved Populations Reveals the Genetic Basis of Body Size Variation in Drosophila melanogaster. [FBrf0213327] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...