Open Close
General Information
Symbol
Dmel\Tor
Species
D. melanogaster
Name
Target of rapamycin
Annotation Symbol
CG5092
Feature Type
FlyBase ID
FBgn0021796
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
dTOR, mTOR, TORC1, FRAP/TOR, l(2)k17004
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:13,004,480..13,013,197 [+]
Recombination map
2-47
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the PI3/PI4-kinase family. (Q9VK45)
Summaries
Gene Group (FlyBase)
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
TORC1 COMPLEX -
TOR complex 1 (TORC1) is a target of rapamycin (Tor) kinase-containing complex that mediates the response to a variety of stimuli including stress, insulin-like peptides and amino acids. TORC1 regulates processes such as translation, cell growth and autophagy. It can be inhibited by rapamycin. (Adapted from FBrf0238220).
TORC2 COMPLEX -
TOR complex 2 (TORC2) is a target of rapamycin (Tor) kinase-containing complex that phosphorylates several AGC family kinases, including Akt1 (PKB). mTORC2 regulates a variety of cellular processes such as insulin signaling and actin reorganization. It is insensitive to rapamycin. (Adapted from FBrf0238220).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Positive Regulators of Insulin-like Receptor Signaling Pathway -
Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Protein Function (UniProtKB)
Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Regulates growth during animal development by coupling growth factor signaling to nutrient availability (PubMed:11069888). Central regulators of autophagy (PubMed:18604198, PubMed:19225150). May be involved in atg1 phosphorylation (PubMed:19225150). May also be involved, directly or indirectly, in the control of neuronal function (PubMed:15454083). Phosphorylates S6K/p70S6K, in vitro (PubMed:11069888). May regulate the activity of S6K (PubMed:11069885). Overexpression inhibits growth and reduces cell size (PubMed:14505573). Affects the timing of neuronal cell differentiation (PubMed:15454083). Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation (PubMed:15454083). Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism (PubMed:14505573). As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR (PubMed:25920570). REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation (PubMed:25920570). When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function (PubMed:25920570). This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes (PubMed:25920570). In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Rag GTPases act as activators of TORC1 in response to amino acid signals (PubMed:18604198).
(UniProt, Q9VK45)
Summary (Interactive Fly)
Phosphatidylinositol 3-kinase - involved in perception of nutrient status - pivotal member of the TOR pathway involved in regulation of growth and cell proliferation
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Tor or the JBrowse view of Dmel\Tor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0080422
7984
2470
FBtr0336615
7987
2471
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0080003
281.0
2470
6.91
FBpp0307598
281.2
2471
6.91
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
May be part of a minimal complex, TORC1, consisting of tor, raptor and lst8. May be part of a minimal complex, TORC2, consisting of tor, rictor and lst8 (By similarity). Self-associates; assembles into homomultimeric complexes. Component of a multiprotein complex.
(UniProt, Q9VK45)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (46 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with UniProtKB:Q9W328
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q7K0T0
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9U9A9
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence model
inferred from sequence or structural similarity with HGNC:3942
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR009076
(assigned by InterPro )
Biological Process (37 terms)
Terms Based on Experimental Evidence (32 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from physical interaction with UniProtKB:C3KKC3
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:3942
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000124197
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:3942
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:3942
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tor in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tor
Transgenic constructs containing regulatory region of Tor
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior fascicle & synapse, with Scer\GAL4elav-C155
dorsal mesothoracic disc & nucleolus
larval salivary gland & nucleus (with Tor2L1)
larval salivary gland & nucleus (with Tork17004)
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
 
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
Yes
1 of 15
Yes
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
13 of 13
Yes
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
3 of 12
Yes
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
6 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
12 of 15
Yes
Yes
2 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
15 of 15
Yes
Yes
13 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
12 of 12
Yes
Yes
9 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919004A )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915003G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W002B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0026 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0046 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
2 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 6 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    May be part of a minimal complex, TORC1, consisting of tor, raptor and lst8. May be part of a minimal complex, TORC2, consisting of tor, rictor and lst8 (By similarity). Self-associates; assembles into homomultimeric complexes. Component of a multiprotein complex.
    (UniProt, Q9VK45 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Insulin-like Receptor Signaling Pathway Core Components -
    The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
    Positive Regulators of Insulin-like Receptor Signaling Pathway -
    Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-47
    Cytogenetic map
    Sequence location
    2L:13,004,480..13,013,197 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    34A4-34A4
    Limits computationally determined from genome sequence between P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639 and P{lacW}l(2)k11328k11328&P{lacW}l(2)k10105k10105
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    34A3-34A4
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (6)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: l(2)k17004 Tor
      Source for database merge of
      Source for merge of: Tor CG5092
      Additional comments
      Other Comments
      Tor is specifically required for developmental axon regrowth but not initial axon outgrowth.
      dsRNA made from templates generated with primers directed against this gene results in a reduced mean cell diameter and a corresponding decrease in S6k phosphorylation. Silencing Tor generates a cell-expression profile similar to that of rapamycin-treated cells.
      dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.
      dsRNA made from templates generated with primers directed against this gene decreases the level of phosphorylation of both Akt1 and S6k in S2 cells.
      Allelic series: TorR248stop = TorQ528stop = TorV2148D > TorG2256D = Tor2L1 > TorR97C = TorE161K = TorA948V = TorW1251R based on the stage of lethality.
      Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.
      When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, a decrease in cell size and a decrease in cytokinetic index is seen.
      Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body. Tor suppresses autophagy independently of S6k.
      Loss of Tor activity causes induction of autophagy in normally fed animals.
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 85 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      modMine - A data warehouse for the modENCODE project
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      ApoDroso - Functional genomic database for photoreceptor development, survival and function
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (31)
      Reported As
      Symbol Synonym
      TOR
      (Bayliak et al., 2019, Chaplot et al., 2019, Hansen et al., 2019, Kim and Choi, 2019, Zheng et al., 2019, Gáliková and Klepsatel, 2018, Kang et al., 2018, Kounatidis and Chtarbanova, 2018, Lee et al., 2018, Lehmann, 2018, Tang et al., 2018, Filer et al., 2017, Haller et al., 2017, Hoedjes et al., 2017, Kamalesh et al., 2017, Kim et al., 2017, Liu et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Romero-Pozuelo et al., 2017, Strilbytska et al., 2017, Tue et al., 2017, Xiang et al., 2017, Alfa and Kim, 2016, Cannon and Bodmer, 2016, Kuleesha et al., 2016, Li et al., 2016, Marmor-Kollet and Schuldiner, 2016, Niwa and Niwa, 2016, Purice et al., 2016, Rabinovich et al., 2016, Tsokanos et al., 2016, Yaniv and Schuldiner, 2016, Burn et al., 2015, Diop and Bodmer, 2015, Diop et al., 2015, Homem et al., 2015, Ma et al., 2015, Nässel et al., 2015, Obata and Miura, 2015, Schmitt et al., 2015, Tiebe et al., 2015, Wang et al., 2015, Barrio et al., 2014, Frank, 2014, Ghosh et al., 2014, Mulakkal et al., 2014, Nagy et al., 2014, Owusu-Ansah and Perrimon, 2014, Varma et al., 2014, Xu and Cherry, 2014, Callier and Nijhout, 2013, Esslinger et al., 2013, Gems and Partridge, 2013, Lee and Brey, 2013, Luo et al., 2013, Mukherjee and Duttaroy, 2013, Nowak et al., 2013, Rajan and Perrimon, 2013, Rallis et al., 2013, Tixier et al., 2013, Tran et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Eleftherianos and Castillo, 2012, Ferguson et al., 2012, Grewal, 2012, Kayashima et al., 2012, Marshall et al., 2012, Rincon-Limas et al., 2012, Yaniv et al., 2012, Boyd et al., 2011, Glatter et al., 2011, Lindquist et al., 2011, Oldham, 2011, Parker, 2011, Partridge et al., 2011, Rajan and Perrimon, 2011, Birse et al., 2010, Bjedov et al., 2010, Bryk et al., 2010, Chang and Neufeld, 2010, Iijima-Ando and Iijima, 2010, Lee et al., 2010, Li et al., 2010, Liu and Lu, 2010, Ribeiro and Dickson, 2010, Vargas et al., 2010, Chang and Neufeld, 2009, Kourtis and Tavernarakis, 2009, Dutta and Baehrecke, 2008, Kaplan et al., 2008, Layalle et al., 2008, Lee et al., 2008, Leopold and Layalle, 2008, McNeill et al., 2008, Oldham et al., 2008, Teleman et al., 2008, Ballard and Wharton, 2007, Berry and Baehrecke, 2007, Grewal et al., 2007, Hall et al., 2007, Hoshizaki and Gibbs, 2007, Lee et al., 2007, Ocorr et al., 2007, Wessells et al., 2007, Edgar, 2006, Goraksha and Neufeld, 2006, Guertin et al., 2006, Hennig et al., 2006, Khurana et al., 2006, Min et al., 2006, Mosimann et al., 2006, Ruvinsky, 2006, Takacs-Vellai, 2006, Wu and Brown, 2006, Yang et al., 2006, Bodmer, 2005, Cygnar et al., 2005, Goberdhan et al., 2005, Grewal et al., 2005, Scott et al., 2005, Shingleton, 2005, Teleman et al., 2005, Hay and Sonenberg, 2004, Pan et al., 2004, Scott et al., 2004, Scott et al., 2004, Stocker et al., 2004, Tatar et al., 2004, Tu and Tatar, 2004, Bergmann and Lane, 2003, Nijhout, 2003, Saucedo et al., 2003, Saucedo et al., 2003, Scott and Neufeld, 2003, Stocker et al., 2003, Oldham et al., 2001)
      Tor
      (Birnbaum et al., 2019, Huang et al., 2019, Johnson and Toettcher, 2019, Li et al., 2019, Lin et al., 2019, Meltzer et al., 2019, Texada et al., 2019, Westfall et al., 2019, Cara et al., 2018, Kang et al., 2018, Kuo et al., 2018, Lee et al., 2018, Leow et al., 2018, Tamirisa et al., 2018, Tsai et al., 2018, Velentzas et al., 2018, Galluzzi et al., 2017, Johnson et al., 2017, Lee et al., 2017, Perry et al., 2017, Song et al., 2017, Wen et al., 2017, Xu et al., 2017, Xu et al., 2017, Yan et al., 2017, Kučerová et al., 2016, Liu et al., 2016, Penney et al., 2016, Puah and Wasser, 2016, Sarov et al., 2016, Wei et al., 2016, Aradska et al., 2015, Diop et al., 2015, Francis and Ghabrial, 2015, Frankel et al., 2015, Gilboa, 2015, Lin et al., 2015, Mensah et al., 2015, Okada et al., 2015, Onyenwoke et al., 2015, Stratoulias and Heino, 2015, Wu et al., 2015, Xu et al., 2015, Adamson et al., 2014, Deivasigamani et al., 2014, Gómez-Lamarca et al., 2014, Hasygar and Hietakangas, 2014, Moy et al., 2014, Pathak et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Wei et al., 2014, Brianti et al., 2013, O'Farrell et al., 2013, Soh et al., 2013, Tang et al., 2013, Tixier et al., 2013, Tixier et al., 2013, Vilmos et al., 2013, Adamson and Lajeunesse, 2012, Avet-Rochex et al., 2012, Chakrabarti et al., 2012, Dar et al., 2012, Dimitroff et al., 2012, Garcia et al., 2012, Pritchett and McCall, 2012, Tokusumi et al., 2012, Zhang et al., 2012, Djiane et al., 2011, Friedman et al., 2011, Lindquist et al., 2011, Read, 2011, Resnik-Docampo and de Celis, 2011, Sousa-Nunes et al., 2011, Tang et al., 2011, Turner et al., 2011, Willecke et al., 2011, Ballard et al., 2010, Blanco et al., 2010, Bülow et al., 2010, Cully et al., 2010, Fernández-Ayala et al., 2010, Haberman et al., 2010, Hsieh et al., 2010, Johnson et al., 2010, Kim et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Nisoli et al., 2010, Robinson et al., 2010, Sun et al., 2010, Sun et al., 2010, Zeng et al., 2010, Zhang et al., 2010, Zheng and Sehgal, 2010, Alvarez-Ponce et al., 2009, Chittaranjan et al., 2009, Koike-Kumagai et al., 2009, Kuronen et al., 2009, Nuzhdin et al., 2009, Patch et al., 2009, Sims et al., 2009, Wang and Huang, 2009, Harvey et al., 2008, Holloway et al., 2008, Hou et al., 2008, Juhász et al., 2008, Rehmann et al., 2008, Song et al., 2008, Derré et al., 2007, Frei et al., 2007, Grewal et al., 2007, Juhász et al., 2007, Kim and Yoo, 2007, Knox et al., 2007, Martin et al., 2007, Miranda-Saavedra and Barton, 2007, Parisi et al., 2007, Scott et al., 2007, Scott et al., 2007, Chen et al., 2006, Friedman and Perrimon, 2006, Hariharan, 2006, Patel and Tamanoi, 2006, Walker et al., 2006, Bateman and McNeill, 2005, Mandal et al., 2005, Teleman et al., 2005, Terashima and Bownes, 2005)
      dTOR
      (Lushchak et al., 2019, Westfall et al., 2019, Staats et al., 2018, Westfall et al., 2018, Bolukbasi et al., 2017, Brookheart and Duncan, 2016, David-Morrison et al., 2016, Erdogan et al., 2016, Wu and Storey, 2016, Chen et al., 2015, Kohlmaier et al., 2015, Merkling and van Rij, 2013, Mockett and Nobles, 2013, Shim et al., 2013, Wu et al., 2013, Eleftherianos and Castillo, 2012, Taillebourg et al., 2012, Kamakura, 2011, Nishimura et al., 2011, Partridge et al., 2011, Dekanty et al., 2010, Karbowniczek et al., 2010, Thomson and Johnson, 2010, Zirin and Perrimon, 2010, Wang and Huang, 2009, Wessells et al., 2009, Mattila et al., 2008, Findlay et al., 2007, Lasko and Sonenberg, 2007, Lee et al., 2007, Wu et al., 2007, Guertin et al., 2006, Inoki and Guan, 2006, Luong et al., 2006, Wullschleger, 2006, Yang et al., 2006, Dekanty et al., 2005, Goraksha and Neufeld, 2005, Sarbassov et al., 2005, Buch et al., 2004, Jorgensen and Tyers, 2004, Kapahi et al., 2004, Kapahi et al., 2004, Oldham et al., 2004, Ruhf et al., 2004, Sarbassov et al., 2004, Sarbassov et al., 2004, Bradley and Leevers, 2003, Hennig et al., 2003, Jacinto and Hall, 2003, Lee and Orr-Weaver, 2003, Lizcano et al., 2003, Manning and Cantley, 2003, Miron et al., 2003, Oldham and Hafen, 2003, Hennig and Neufeld, 2002, Hennig and Neufeld, 2002, Kozma and Thomas, 2002, Marygold and Leevers, 2002, Montagne et al., 2002, Radimerski et al., 2002, Radimerski et al., 2002, Cho et al., 2001, Gingras et al., 2001, Potter and Xu, 2001, Prober and Edgar, 2001, Radimerski et al., 2001, Rhode et al., 2001, Oldham et al., 2000, Oldham et al., 2000, Zhang et al., 2000)
      Name Synonyms
      Target-of-Rapamycin
      Target-of-rapamycin
      target of rapamycin complex 1
      target of rapamycin kinase
      Secondary FlyBase IDs
      • FBgn0032466
      Datasets (1)
      Study focus (1)
      Experimental Role
      Project
      Project Type
      Title
      • bait_protein
      Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
      References (512)