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Gene Dmel\Xbp1

General Information
Symbol	Dmel\Xbp1	Species	D. melanogaster
Name	X box binding protein-1	Annotation symbol	CG9415
Feature type	protein_coding_gene	FlyBase ID	FBgn0021872
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	XBP-1, Dxbp-1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57C3-57C4	Sequence location	2R:17,031,050..17,033,255 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene X box binding protein-1 is referred to in FlyBase by the symbol Dmel\Xbp1 (CG9415, FBgn0021872). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process: chaeta development; endoplasmic reticulum unfolded protein response; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; wing disc development; lateral inhibition; response to endoplasmic reticulum stress. 12 alleles are reported. The phenotypes of these alleles are annotated with: eye; eye photoreceptor cell; tormogen cell; scutellar bristle; wing; imaginal disc; scutum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Basic leucine zipper; Basic-leucine zipper (bZIP) transcription factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1635355_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Xbp1. Gene sequence location is 2R:17031050..17033255.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Clones AT23514 SD02172 Transcripts Xbp1-RD Xbp1-RE Polypeptides Xbp1-PD Xbp1-PE
FB2012_01	Sequence features HFA04553 BKN22698 Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57C3-57C4   Limits computationally determined from genome sequence between P{PZ}king-tubby02821&P{lacW}Xbp1k13803 and P{EP}CG4266EP2258
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57C1-57C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 57C1-57C2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Xbp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene with transcript subject to HAC1-type intron splice site recognition and cleavage, creating a frameshift; highly conserved phenomenon (FBrf0194899). Gene model reviewed during 5.42 Multiphase exon postulated: exon reading frame varies in alternative transcripts (FBrf0194899). Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Xbp1-RD FBtr0310044     2142   307 Xbp1-RE FBtr0310045     2119   498
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Xbp1-PD   FBpp0301745   33.7   307   9.80       Xbp1-PE   FBpp0301746   53.1   498   4.41
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper (bZIP) transcription factor (IPR004827) Basic leucine zipper (IPR011700)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201136   AA201806   AA540305   AA695440   AA695899   AA697310   AA801496   AA801531   AA802201   AA948783   AA978462   AI062088   AI064346   AI106719   AI107469   AI109867   AI114167   AI124272   AI134575   AI135082   AI135692   AI238404   AI239041   AI258879   AI259650   AI260559   AI260937   AI292587   AI295568   AI296564   AI296780   AI297174   AI388461   AI388977   AI390012   AI402166   AI402519   AI403014   AI403652   AI403931   AI405275   AI406002   AI516917   AI517731   AI518545   AI519312   AI530948   AI531216   AI531227   AI531511   AI531669   AI531883   AI532383   AI532730   AI533305   AI533330   AI533966   AI534110   AI534312   AI541633   AI542297   AI542449   AI542616   AI543014   AI543225   AI543614   AI544300   AQ034031   AQ072913   AY059442   BF488279   BF494116   BF498063   BF500214   BG632613   BG635492   BG635607   BG635898   BG635973   BG636386   BG636893   BG637205   BG639319   BG639538   BG640153   BG641180   BG641376   BI141831   BI141863   BI141979   BI163813   BI173769   BI212993   BI214077   BI215902   BI228005   BI231066   BI231945   BI238201   BI239885   BI239964   BI241009   BI243748   BI351607   BI351795   BI351830   BI352142   BI363056   BI366767   BI369821   BI564016   BI567691   BI569719   BI569770   BI570908   BI572101   BI575997   BI579472   BI582046   BI582229   BI582735   BI585144   BI585258   BI586267   BI587605   BI587920   BI589321   BI589695   BI589800   BI590881   BI591634   BI592179   BI611304   BI613662   BI613895   BI614172   BI616558   BI617365   BI618579   BI620295   BI622140   BI623154   BI623172   BI624019   BI624452   BI626181   BI626982   BI630422   BI630509   BI630552   BI631439   BI632437   BI633177   BI633434   BI633692   BI633944   BI635168   BI635290   BI635361   BI635862   BI636128   BI636288   BI636356   BI636643   BI636974   BI637139   BI637701   BI638750   BI638797   BI638851   BI639298   BI639357   BI639534   BI639695   BI639761   BI639975   BI640161   BI640264   BI640731   BI640986   BI641030   BP541376   BP551851   BP552337   BT021380 AAX33528   CK131829   CK657250   CK657493   CK657638   CK661176   CK661666   CK662465   CO153678   CO155939   CO156041   CO156770   CO180207   CO271055   CO272469   CO272628   CO280823   CO281654   CO287936   CO295554   CO303349   CO315671   CO321603   CO327495   CO336392   CO336645   CO336906   CO337886   CO339519   CO341145   CZ476377   DN154179   EC054235   EC061924   EC062992   EC063992   EC064037   EC064339   EC077076   EC089179   EC197368   EC197892   EC199475   EC207555   EC223766   EC226164   EC246685   EC251257   EC254704   EC255316   EC255320   EC259178   EC261429   EC262181   EC262384   EC262724   EC262986   EC264214   EC264342   EC264816   EL870373   EL884832   EL885084   ES689773   EV579907   EV594796   GH945762   GH946096   GH946227   GH953751   GH953903   GH954150   GH955146   GH958965   GH959147   GH961842   GH965271   GH966372   GH976286   GH981488
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MLW7 Q5BI44
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0021872    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0021872 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0021872 expression level Developmental Stage   Expression Level embryo 00-02hr    8842 embryo 02-04hr    3240 embryo 04-06hr    3627 embryo 06-08hr    10220 embryo 08-10hr    14706 embryo 10-12hr    29353 embryo 12-14hr    15976 embryo 14-16hr    21266 embryo 16-18hr    18140 embryo 18-20hr    18310 embryo 20-22hr    16008 embryo 22-24hr    14691 larva L1    17094 larva L2    15772 larva L3 12hr old    17703 larva L3 puffstage 1-2    14384 larva L3 puffstage 3-6    16122 larva L3 puffstage 7-9    15286 white prepupae new    13211 white prepupae 12hr    9664 white prepupae 24hr    13428 pupae 2d postWPP    12494 pupae 3d postWPP    12140 pupae 4d postWPP    15486 adult male 01day    14567 adult male 05day    16982 adult male 30day    19345 adult female 01day    16577 adult female 05day    11126 adult female 30day    11910 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8842) embryo 02-04hr  (3240) embryo 04-06hr  (3627) embryo 06-08hr  (10220) embryo 08-10hr  (14706) embryo 10-12hr  (29353) embryo 12-14hr  (15976) embryo 14-16hr  (21266) embryo 16-18hr  (18140) embryo 18-20hr  (18310) embryo 20-22hr  (16008) embryo 22-24hr  (14691) larva L1  (17094) larva L2  (15772) larva L3 12hr old  (17703) larva L3 puffstage 1-2  (14384) larva L3 puffstage 3-6  (16122) larva L3 puffstage 7-9  (15286) white prepupae new  (13211) white prepupae 12hr  (9664) white prepupae 24hr  (13428) pupae 2d postWPP  (12494) pupae 3d postWPP  (12140) pupae 4d postWPP  (15486) adult male 01day  (14567) adult male 05day  (16982) adult male 30day  (19345) adult female 01day  (16577) adult female 05day  (11126) adult female 30day  (11910) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8842) embryo 02-04hr  (3240) embryo 04-06hr  (3627) embryo 06-08hr  (10220) embryo 08-10hr  (14706) embryo 10-12hr  (29353) embryo 12-14hr  (15976) embryo 14-16hr  (21266) embryo 16-18hr  (18140) embryo 18-20hr  (18310) embryo 20-22hr  (16008) embryo 22-24hr  (14691) larva L1  (17094) larva L2  (15772) larva L3 12hr old  (17703) larva L3 puffstage 1-2  (14384) larva L3 puffstage 3-6  (16122) larva L3 puffstage 7-9  (15286) white prepupae new  (13211) white prepupae 12hr  (9664) white prepupae 24hr  (13428) pupae 2d postWPP  (12494) pupae 3d postWPP  (12140) pupae 4d postWPP  (15486) adult male 01day  (14567) adult male 05day  (16982) adult male 30day  (19345) adult female 01day  (16577) adult female 05day  (11126) adult female 30day  (11910) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8842 embryo 02-04hr    3240 embryo 04-06hr    3627 embryo 06-08hr  10220 embryo 08-10hr  (14706) embryo 10-12hr  (29353) embryo 12-14hr  (15976) embryo 14-16hr  (21266) embryo 16-18hr  (18140) embryo 18-20hr  (18310) embryo 20-22hr  (16008) embryo 22-24hr  (14691) larva L1  (17094) larva L2  (15772) larva L3 12hr old  (17703) larva L3 puffstage 1-2  (14384) larva L3 puffstage 3-6  (16122) larva L3 puffstage 7-9  (15286) white prepupae new  (13211) white prepupae 12hr    9664 white prepupae 24hr  (13428) pupae 2d postWPP  (12494) pupae 3d postWPP  (12140) pupae 4d postWPP  (15486) adult male 01day  (14567) adult male 05day  (16982) adult male 30day  (19345) adult female 01day  (16577) adult female 05day  (11126) adult female 30day  (11910) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8842 embryo 02-04hr    3240 embryo 04-06hr    3627 embryo 06-08hr    10220 embryo 08-10hr    14706 embryo 10-12hr    29353 embryo 12-14hr    15976 embryo 14-16hr    21266 embryo 16-18hr    18140 embryo 18-20hr    18310 embryo 20-22hr    16008 embryo 22-24hr    14691 larva L1    17094 larva L2    15772 larva L3 12hr old    17703 larva L3 puffstage 1-2    14384 larva L3 puffstage 3-6    16122 larva L3 puffstage 7-9    15286 white prepupae new    13211 white prepupae 12hr    9664 white prepupae 24hr    13428 pupae 2d postWPP    12494 pupae 3d postWPP    12140 pupae 4d postWPP    15486 adult male 01day    14567 adult male 05day    16982 adult male 30day    19345 adult female 01day    16577 adult female 05day    11126 adult female 30day    11910 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0021872 expression level Developmental Stage   Expression Level embryo 00-02hr    8842 embryo 02-04hr    3240 embryo 04-06hr    3627 embryo 06-08hr    10220 embryo 08-10hr    14706 embryo 10-12hr    29353 embryo 12-14hr    15976 embryo 14-16hr    21266 embryo 16-18hr    18140 embryo 18-20hr    18310 embryo 20-22hr    16008 embryo 22-24hr    14691 larva L1    17094 larva L2    15772 larva L3 12hr old    17703 larva L3 puffstage 1-2    14384 larva L3 puffstage 3-6    16122 larva L3 puffstage 7-9    15286 white prepupae new    13211 white prepupae 12hr    9664 white prepupae 24hr    13428 pupae 2d postWPP    12494 pupae 3d postWPP    12140 pupae 4d postWPP    15486 adult male 01day    14567 adult male 05day    16982 adult male 30day    19345 adult female 01day    16577 adult female 05day    11126 adult female 30day    11910 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8842) embryo 02-04hr  (3240) embryo 04-06hr  (3627) embryo 06-08hr  (10220) embryo 08-10hr  (14706) embryo 10-12hr  (29353) embryo 12-14hr  (15976) embryo 14-16hr  (21266) embryo 16-18hr  (18140) embryo 18-20hr  (18310) embryo 20-22hr  (16008) embryo 22-24hr  (14691) larva L1  (17094) larva L2  (15772) larva L3 12hr old  (17703) larva L3 puffstage 1-2  (14384) larva L3 puffstage 3-6  (16122) larva L3 puffstage 7-9  (15286) white prepupae new  (13211) white prepupae 12hr  (9664) white prepupae 24hr  (13428) pupae 2d postWPP  (12494) pupae 3d postWPP  (12140) pupae 4d postWPP  (15486) adult male 01day  (14567) adult male 05day  (16982) adult male 30day  (19345) adult female 01day  (16577) adult female 05day  (11126) adult female 30day  (11910) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8842) embryo 02-04hr  (3240) embryo 04-06hr  (3627) embryo 06-08hr  (10220) embryo 08-10hr  (14706) embryo 10-12hr  (29353) embryo 12-14hr  (15976) embryo 14-16hr  (21266) embryo 16-18hr  (18140) embryo 18-20hr  (18310) embryo 20-22hr  (16008) embryo 22-24hr  (14691) larva L1  (17094) larva L2  (15772) larva L3 12hr old  (17703) larva L3 puffstage 1-2  (14384) larva L3 puffstage 3-6  (16122) larva L3 puffstage 7-9  (15286) white prepupae new  (13211) white prepupae 12hr  (9664) white prepupae 24hr  (13428) pupae 2d postWPP  (12494) pupae 3d postWPP  (12140) pupae 4d postWPP  (15486) adult male 01day  (14567) adult male 05day  (16982) adult male 30day  (19345) adult female 01day  (16577) adult female 05day  (11126) adult female 30day  (11910) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8842 embryo 02-04hr    3240 embryo 04-06hr    3627 embryo 06-08hr  10220 embryo 08-10hr  14706 embryo 10-12hr  (29353) embryo 12-14hr  15976 embryo 14-16hr  (21266) embryo 16-18hr  18140 embryo 18-20hr  18310 embryo 20-22hr  16008 embryo 22-24hr  14691 larva L1  17094 larva L2  15772 larva L3 12hr old  17703 larva L3 puffstage 1-2  14384 larva L3 puffstage 3-6  16122 larva L3 puffstage 7-9  15286 white prepupae new  13211 white prepupae 12hr    9664 white prepupae 24hr  13428 pupae 2d postWPP  12494 pupae 3d postWPP  12140 pupae 4d postWPP  15486 adult male 01day  14567 adult male 05day  16982 adult male 30day  19345 adult female 01day  16577 adult female 05day  11126 adult female 30day  11910 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8842 embryo 02-04hr    3240 embryo 04-06hr    3627 embryo 06-08hr    10220 embryo 08-10hr    14706 embryo 10-12hr    29353 embryo 12-14hr    15976 embryo 14-16hr    21266 embryo 16-18hr    18140 embryo 18-20hr    18310 embryo 20-22hr    16008 embryo 22-24hr    14691 larva L1    17094 larva L2    15772 larva L3 12hr old    17703 larva L3 puffstage 1-2    14384 larva L3 puffstage 3-6    16122 larva L3 puffstage 7-9    15286 white prepupae new    13211 white prepupae 12hr    9664 white prepupae 24hr    13428 pupae 2d postWPP    12494 pupae 3d postWPP    12140 pupae 4d postWPP    15486 adult male 01day    14567 adult male 05day    16982 adult male 30day    19345 adult female 01day    16577 adult female 05day    11126 adult female 30day    11910 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0021872    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0021872 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0021872 expression level Tissue   Expression Level Larval Central Nervous System    643.175 Larval Midgut    1181.6 Larval Hindgut    1170.2 Larval Malpighian Tubules    968.4 Larval Fat Body    1301.9 Larval Salivary Gland    2343.5 Larval Trachea    401.175 Larval Carcass    1176.075 Adult Head    809.8 Adult Eye    504.6 Adult Brain    769.8 Adult Thoracic-Abdominal Ganglion    1019.2 Adult Crop    1786.9 Adult Midgut    1022.7 Adult Hindgut    1421 Adult Malpighian Tubules    878.7 Adult Fat Body    1464.9 Adult Salivary Gland    2952.1 Adult Heart    1006.575 Adult VirginFemale Spermatheca    2100.2 Adult InseminatedFemale Spermatheca    1937.8 Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland    2040.2 Adult Carcass    1240.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (643.175) Larval Midgut  (1181.6) Larval Hindgut  (1170.2) Larval Malpighian Tubules  (968.4) Larval Fat Body  (1301.9) Larval Salivary Gland  (2343.5) Larval Trachea    401.175 Larval Carcass  (1176.075) Adult Head  (809.8) Adult Eye  504.6 Adult Brain  (769.8) Adult Thoracic-Abdominal Ganglion  (1019.2) Adult Crop  (1786.9) Adult Midgut  (1022.7) Adult Hindgut  (1421) Adult Malpighian Tubules  (878.7) Adult Fat Body  (1464.9) Adult Salivary Gland  (2952.1) Adult Heart  (1006.575) Adult VirginFemale Spermatheca  (2100.2) Adult InseminatedFemale Spermatheca  (1937.8) Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland  (2040.2) Adult Carcass  (1240.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    643.175 Larval Midgut  (1181.6) Larval Hindgut  (1170.2) Larval Malpighian Tubules    968.4 Larval Fat Body  (1301.9) Larval Salivary Gland  (2343.5) Larval Trachea    401.175 Larval Carcass  (1176.075) Adult Head    809.8 Adult Eye    504.6 Adult Brain    769.8 Adult Thoracic-Abdominal Ganglion  1019.2 Adult Crop  (1786.9) Adult Midgut  1022.7 Adult Hindgut  (1421) Adult Malpighian Tubules    878.7 Adult Fat Body  (1464.9) Adult Salivary Gland  (2952.1) Adult Heart  1006.575 Adult VirginFemale Spermatheca  (2100.2) Adult InseminatedFemale Spermatheca  (1937.8) Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland  (2040.2) Adult Carcass  (1240.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    643.175 Larval Midgut    1181.6 Larval Hindgut    1170.2 Larval Malpighian Tubules    968.4 Larval Fat Body    1301.9 Larval Salivary Gland    2343.5 Larval Trachea    401.175 Larval Carcass    1176.075 Adult Head    809.8 Adult Eye    504.6 Adult Brain    769.8 Adult Thoracic-Abdominal Ganglion    1019.2 Adult Crop    1786.9 Adult Midgut    1022.7 Adult Hindgut    1421 Adult Malpighian Tubules    878.7 Adult Fat Body    1464.9 Adult Salivary Gland    2952.1 Adult Heart    1006.575 Adult VirginFemale Spermatheca    2100.2 Adult InseminatedFemale Spermatheca    1937.8 Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland    2040.2 Adult Carcass    1240.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0021872 expression level Tissue   Expression Level Larval Central Nervous System    643.175 Larval Midgut    1181.6 Larval Hindgut    1170.2 Larval Malpighian Tubules    968.4 Larval Fat Body    1301.9 Larval Salivary Gland    2343.5 Larval Trachea    401.175 Larval Carcass    1176.075 Adult Head    809.8 Adult Eye    504.6 Adult Brain    769.8 Adult Thoracic-Abdominal Ganglion    1019.2 Adult Crop    1786.9 Adult Midgut    1022.7 Adult Hindgut    1421 Adult Malpighian Tubules    878.7 Adult Fat Body    1464.9 Adult Salivary Gland    2952.1 Adult Heart    1006.575 Adult VirginFemale Spermatheca    2100.2 Adult InseminatedFemale Spermatheca    1937.8 Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland    2040.2 Adult Carcass    1240.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  643.175 Larval Midgut  (1181.6) Larval Hindgut  (1170.2) Larval Malpighian Tubules  (968.4) Larval Fat Body  (1301.9) Larval Salivary Gland  (2343.5) Larval Trachea    401.175 Larval Carcass  (1176.075) Adult Head  809.8 Adult Eye  504.6 Adult Brain  769.8 Adult Thoracic-Abdominal Ganglion  (1019.2) Adult Crop  (1786.9) Adult Midgut  (1022.7) Adult Hindgut  (1421) Adult Malpighian Tubules  (878.7) Adult Fat Body  (1464.9) Adult Salivary Gland  (2952.1) Adult Heart  (1006.575) Adult VirginFemale Spermatheca  (2100.2) Adult InseminatedFemale Spermatheca  (1937.8) Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland  (2040.2) Adult Carcass  (1240.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    643.175 Larval Midgut  1181.6 Larval Hindgut  1170.2 Larval Malpighian Tubules    968.4 Larval Fat Body  1301.9 Larval Salivary Gland  (2343.5) Larval Trachea    401.175 Larval Carcass  1176.075 Adult Head    809.8 Adult Eye    504.6 Adult Brain    769.8 Adult Thoracic-Abdominal Ganglion  1019.2 Adult Crop  (1786.9) Adult Midgut  1022.7 Adult Hindgut  1421 Adult Malpighian Tubules    878.7 Adult Fat Body  1464.9 Adult Salivary Gland  (2952.1) Adult Heart  1006.575 Adult VirginFemale Spermatheca  (2100.2) Adult InseminatedFemale Spermatheca  (1937.8) Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland  (2040.2) Adult Carcass  1240.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    643.175 Larval Midgut    1181.6 Larval Hindgut    1170.2 Larval Malpighian Tubules    968.4 Larval Fat Body    1301.9 Larval Salivary Gland    2343.5 Larval Trachea    401.175 Larval Carcass    1176.075 Adult Head    809.8 Adult Eye    504.6 Adult Brain    769.8 Adult Thoracic-Abdominal Ganglion    1019.2 Adult Crop    1786.9 Adult Midgut    1022.7 Adult Hindgut    1421 Adult Malpighian Tubules    878.7 Adult Fat Body    1464.9 Adult Salivary Gland    2952.1 Adult Heart    1006.575 Adult VirginFemale Spermatheca    2100.2 Adult InseminatedFemale Spermatheca    1937.8 Adult Ovary    274.9 Adult Testis    166.4 Adult Male Accessory Gland    2040.2 Adult Carcass    1240.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    809.8   NA  Eye    504.6   NA  Brain    769.8   643.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1019.2   NA  Crop    1786.9   1181.6  Midgut    1022.7   1170.2  Hindgut    1421   968.4  Malpighian Tubules    878.7   1301.9  Fat Body    1464.9   2343.5  Salivary Gland    2952.1   NA  Heart    1006.575   401.175  Trachea    NA   NA  VirginFemale Spermatheca    2100.2   NA  InseminatedFemale Spermatheca    1937.8   NA  Ovary    274.9   NA  Testis    166.4   NA  Male Accessory Gland    2040.2   1176.075  Carcass    1240.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021872 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9415-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Xbp1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Xbp1CB02061 lethal (with Df(2R)CC2) Xbp1k13803 lethal | first instar larval stage | recessive Xbp1k13803 lethal | recessive Xbp1k13803 lethal | recessive | second instar larval stage Xbp1k13803 semi-lethal, with Scer\GAL4ap-md544 Xbp1GD4745 viable, with Scer\GAL4pnr-MD237 Xbp1GD4745 Other Phenotypes Allele developmental rate defective | recessive Xbp1k13803 hypoactive | first instar larval stage | recessive Xbp1k13803 increased cell death, with Scer\GAL4elav-C155 Xbp1GD4745 increased cell death, with Scer\GAL4GMR.PF Xbp1Scer\UAS.RB increased cell death, with Scer\GAL4ninaE.PT Xbp1Scer\UAS.RB neuroanatomy defective, with Scer\GAL4elav-C155 Xbp1GD4745 visible, with Scer\GAL4pnr-MD237 Xbp1GD4745 Phenotype manifest in Allele autophagic vacuole & larval fat body | somatic clone | cell autonomous Xbp1k13803 autophagic vacuole & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP Xbp1Scer\UAS.RB chaeta | supernumerary, with Scer\GAL4pnr-MD237 Xbp1GD4745 eye, with Scer\GAL4GMR.PF Xbp1Scer\UAS.RB eye photoreceptor cell, with Scer\GAL4ninaE.PT Xbp1Scer\UAS.RB imaginal disc (with Df(2R)F36) Xbp1k13803 lysosome & larval fat body | somatic clone | cell autonomous Xbp1k13803 lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP Xbp1Scer\UAS.RB macrochaeta | supernumerary, with Scer\GAL4ap-md544 Xbp1GD4745 macrochaeta | supernumerary, with Scer\GAL4pnr-MD237 Xbp1GD4745 scutellar bristle, with Scer\GAL4pnr-MD237 Xbp1GD4745 scutum, with Scer\GAL4ap-md544 Xbp1GD4745 scutum, with Scer\GAL4pnr-MD237 Xbp1GD4745 tormogen cell, with Scer\GAL4pnr-MD237 Xbp1GD4745 wing, with Scer\GAL4ap-md544 Xbp1GD4745
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Xbp1 Class Mutagen Stocks Known lesion Xbp1DG20703 2 -- Xbp1k13803 loss of function allele P-element activity 2 Yes Xbp1CB02061 P-element activity 0 Yes Xbp1d08698 P-element activity 0 -- Xbp1EP2112 P-element activity 0 -- Xbp1excP wild-type allele Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Xbp1 Class Mutagen Stocks Known lesion Xbp1GD4745 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Xbp1JF02012 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Xbp1KK102632 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Xbp1Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Xbp1Scer\UAS.RB in vitro construct - regulatory fusion 0 Yes Xbp1Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC484 (Christensen et al., 2008.4.15) Df(2R)CC2 (Souid et al., 2007) Df(2R)Exel6072 (Ryder, 2004.4.26) Df(2R)Exel6073 (Ryder, 2004.4.26) Df(2R)Exel7167 (Ryder, 2004.4.26) Df(2R)F36 (Ryoo et al., 2007) Df(2R)Pu-D17 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)XE3030 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)E3578 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4745} NA P{KK102632} NA P{TRiP.JF02012} NA P{UAS-Xbp1.EGFP} NA P{UAS-Xbp1.RB} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH1050SH1050 No P{lacW}Xbp1k13803 No insertion of mobile activating element P{EP}Xbp1EP2112 NA P{XP}Xbp1d08698 NA miscellaneous insertions P{PTT-GB}Xbp1CB02061 NA P{wHy}Xbp1DG20703 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chaeta development inferred from genetic interaction with Chi (Bronstein et al., 2010) inferred from genetic interaction with Ssdp (Bronstein et al., 2010) inferred from mutant phenotype (Bronstein et al., 2010) endoplasmic reticulum unfolded protein response inferred from direct assay (Ryoo et al., 2007, Plongthongkum et al., 2007) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response inferred from direct assay (Plongthongkum et al., 2007) response to endoplasmic reticulum stress inferred from direct assay (Ryoo et al., 2007, Plongthongkum et al., 2007) wing disc development inferred from genetic interaction with ap (Bronstein et al., 2010) inferred from genetic interaction with Bx (Bronstein et al., 2010) inferred from mutant phenotype (Bronstein et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
protein dimerization activity inferred from electronic annotation with InterPro:IPR011700 (FlyBase Curators et al., 2004-) protein homodimerization activity inferred from sequence or structural similarity (Fassler et al., 2002) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR011700 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:AF027963 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with EMBL:AF027963 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:AF027963 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Xbp1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68905 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0021872 DroID - A comprehensive database of gene and protein interactions. • FBgn0021872 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44226
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11937 Dere\GG22091 Dgri\GH20722 Dmoj\GI20807 Dpse\GA25098 Dsec\GM15809 Dsim\GD11567 Dvir\GJ20540 Dwil\GK19655 Dyak\GE12171
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005558-PA Aedes aegypti (mosquito) AGAP010623-PA Anopheles gambiae (mosquito) XP_392383.2 Apis mellifera (honey bee) 114732 Branchiostoma floridae (lancelet) CBP31476 Caenorhabditis briggsae (nematode) CE40513 Caenorhabditis elegans (worm) ENSCAFP00000017593 Canis familiaris (dog) ENSCINP00000015310 Ciona intestinalis (sea squirt) JA06495 Caenorhabditis japonica (nematode) CPIJ005730 Culex pipens (mosquito) ENSCPOP00000007019 Cavia porcellus (guinea pig) RP38294 Caenorhabditis remanei (nematode) ENSCSAVP00000008810 Ciona savignyi (sedentary tunicate) 221349 Capitella spl (polychaete worm) ENSDARP00000051648 Danio rerio (zebra fish) ENSECAP00000012506 Equus caballus (horse) ENSGACP00000018848 Gymnopilus aculeatus (mushroom) ENSP00000343155 Homo sapiens (human) ENSMODP00000010675 Monodelphis domestica (gray opossum) ENSMMUP00000009460 Macaca mulatta (rhesus monkey) ENSMUSP00000105492 Mus musculus (house mouse) PHUM009694-PA Pediculus humanus (human body louse) ENSPPYP00000013025 Pongo pygmaeus (orangutan) ENSPTRP00000024464 Pan troglodytes (chimpanzee) ENSRNOP00000014044 Rattus norvegicus (norway rat) XP_001176000.1 Strongylocentrotus purpuratus (purple sea urchin) XP_973680.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018695 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041380 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057183 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13553 LH23031 ISCW007440 FBgn0229936 FBgn0221653 FBgn0207680 FBgn0183308 FBgn0170725 JGI_V11_314438 FBgn0246481 FBgn0147766 FBgn0143542 FBgn0128185 FBgn0114266 FBgn0088976 CPIJ005730 BGIBMGA002915 GB17511 AGAP010623 AAEL005558 PB24175 PHUM437880 GLEAN_12878
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	25990 y1 v1; P{TRiP.JF02012}attP2 11104 y1 w67c23; P{lacW}Xbp1k13803/CyO 21744 y1 w67c23; P{wHy}Xbp1DG20703/SM6a
Kyoto	114701 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{wHy}Xbp1DG20703 /CyO y+ 111331 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Xbp1k13803 /CyO y+
VDRC	v15347 w1118; P{GD4745}v15347/TM3
Genomic Clones ( 2 )
	BACR12O13 BACR16B07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 258 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH09250 LD42070
Other clones	DPiM_LD42070
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02539 AT12422 AT14973 AT23514 GH01153 GH04727 GH05166 GH07648 GH10868 GH11342 GH12077 GH12708 GH13534 GH14442 GH15211 GH15526 GH19387 GH20043 GH21453 GH21755 GH22369 GH23135 GH23477 GH25226 GH26179 GH27519 GH28784 GM02830 GM04013 GM04739 GM08136 GM16150 GM16288 GM18047 HL02232 HL06581 LD03808 LD19758 LD27414 LD30649 LD38090 LD38850 LP02177 LP03117 LP03921 LP04470 LP04979 LP09241 LP10519 LP10854 LP11419 LP12850 LP20387 LP21312 LP22715 LP23390 LP23842 LP24103 RE03324 RE17953 RE18286 RE19780 RE22670 RE25128 RE25413 RE34595 RE36496 RE36602 RE37972 RE41470 RE52371 RE56130 RE73515 RH01856 RH01919 RH03289 RH04567 RH05694 RH06387 RH07444 RH09815 RH17490 RH19919 RH20188 RH21032 RH24616 RH24838 RH28326 RH28844 RH31730 RH32441 RH34984 RH38245 RH42869 RH43154 RH43484 RH47688 RH49443 RH51383 RH53966 RH55245 RH55269 RH56392 RH59569 RH59822 RH61014 RH64015 RH66730 RH68144 SD01747 SD02161 SD02190 SD02581 SD02902 SD03173 SD03878 SD04328 SD05067 SD05104 SD05667 SD06339 SD06625 SD07104 SD08562 SD08781 SD09034 SD09576 SD09923 SD10445 SD10803 SD11115 SD12456 SD12703 SD12919 SD13063 SD13415 SD13523 SD14072 SD14713 SD15085 SD15761 SD15825 SD15962 SD16429 SD16592 SD16687 SD17383 SD17703 SD17924 SD18007 SD18386 SD18838 SD19061 SD19760 SD21120 SD21178 SD21245 SD21849 SD21921 SD22135 SD22348 SD22431 SD22715 SD22963 SD23077 SD23716 SD24040 SD24089 SD26218 SD27183 SD27519 SD27839 SD28158
Other clones	8666 41775 42835 61366 65448 65717 76787 77291 81594 121225 124422 156882 214281.53 214289.57 214443.63 214573.44 281697 522689 525755 527081 528224 557809 558079 561966 569742 CK01.85A.C10 CK01.130B.F7 Dmel_dig_006165_0711_1209 Dmel_neb_011384_0606_0623 EC01217 EC054235 EK067343 EK101824 EK107259 EK107847 EK154946 EK157821 EK186015 EK193525 EK210663 EK241138 EK262138 EN02555 EN07053 EN07237 EN09059 EN12437 EN12943 EN13449 EN15517 EP02152 EP07358 EP11938 FGC001A02 FGM215B10 FGM218B10 HL02633 IP02469 IP16060 IP16260 LD03735 RE16869 RE47771 RH03166 RH26148 RH46553 RH59461 RP004010960 RP004017929 RP004102952 RP004119788 RP004122343 RP004124730 RP004221623 RP004224614 RP004227045 RP004230828 RP004323448 RP004480350 RP004494666 RP004531256 SD02172
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0021872 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44226
Antibody Information
	polyclonal (Plongthongkum et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Xbp1 anon-EST:Liang-1.41 (FlyBase, 1996-) Source for merge of: Xbp1 CG9415 (Misra, 2000.8.9)
Additional comments	Source for merge of Xbp1 anon-EST:Liang-1.41 was sequence comparison (date:030707). (FlyBase, 1996-)
Other Comments
	In response to ER stress, the original processed transcript of this gene is subject to HAC1-type intron splice-site recognition and cleavage by the Ire1 gene product. A small intron of 23nt is enzymatically removed, creating a frameshift in the resulting transcript and production of an alternative protein isoform. (Ryoo et al., 2007) Changes in expression profiles associated with the unfolded protein response have been analyzed in S2 cells following treatment with dsRNA made from templates generated with primers directed against this gene. (Hollien and Weissman, 2006) Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology. (Roch et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AA802201 AAM70855 AAX33528 AI109867 AI124272 AI402166 AQ034031 AQ072913 BT021380 CZ476377 Entrez Gene - A searchable database of RefSeq genes. • 44226 UniProtKB/TrEMBL • Q5BI44 Q8MLW7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper (bZIP) transcription factor (IPR004827) Basic leucine zipper (IPR011700)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68905 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0021872 DroID - A comprehensive database of gene and protein interactions. • FBgn0021872 DRSC - Results from RNAi screens. • FBgn0021872 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021872 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9415-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0021872 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44226 InParanoid A subset of ortholog calls from InParanoid. • AAEL005558-PA Aedes aegypti (mosquito) AGAP010623-PA Anopheles gambiae (mosquito) XP_392383.2 Apis mellifera (honey bee) 114732 Branchiostoma floridae (lancelet) CBP31476 Caenorhabditis briggsae (nematode) CE40513 Caenorhabditis elegans (worm) ENSCAFP00000017593 Canis familiaris (dog) ENSCINP00000015310 Ciona intestinalis (sea squirt) JA06495 Caenorhabditis japonica (nematode) CPIJ005730 Culex pipens (mosquito) ENSCPOP00000007019 Cavia porcellus (guinea pig) RP38294 Caenorhabditis remanei (nematode) ENSCSAVP00000008810 Ciona savignyi (sedentary tunicate) 221349 Capitella spl (polychaete worm) ENSDARP00000051648 Danio rerio (zebra fish) ENSECAP00000012506 Equus caballus (horse) ENSGACP00000018848 Gymnopilus aculeatus (mushroom) ENSP00000343155 Homo sapiens (human) ENSMODP00000010675 Monodelphis domestica (gray opossum) ENSMMUP00000009460 Macaca mulatta (rhesus monkey) ENSMUSP00000105492 Mus musculus (house mouse) PHUM009694-PA Pediculus humanus (human body louse) ENSPPYP00000013025 Pongo pygmaeus (orangutan) ENSPTRP00000024464 Pan troglodytes (chimpanzee) ENSRNOP00000014044 Rattus norvegicus (norway rat) XP_001176000.1 Strongylocentrotus purpuratus (purple sea urchin) XP_973680.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018695 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041380 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057183 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44226 modMine - Data generated by the modENCODE project. • FBgn0021872 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13553 LH23031 ISCW007440 FBgn0229936 FBgn0221653 FBgn0207680 FBgn0183308 FBgn0170725 JGI_V11_314438 FBgn0246481 FBgn0147766 FBgn0143542 FBgn0128185 FBgn0114266 FBgn0088976 CPIJ005730 BGIBMGA002915 GB17511 AGAP010623 AAEL005558 PB24175 PHUM437880 GLEAN_12878
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	138/3 (Roch et al., 1998) anon-EST:Liang-1.41   CG9415 (Fassler et al., 2002, Hollien and Weissman, 2006, Perkins et al., 1.15.2009, Bronstein et al., 2010, Keleman et al., 2009.8.5) CG 9415 (Ryoo et al., 2007) clone 1.41 (Liang and Biggin, 1998) Dxbp-1 (Souid et al., 2007) dXbp-1 (Garrey et al., ) l(2)k13803 (BDGP Project Members, 1994-1999, ) xbp1 (Souid et al., 2003, Ryoo et al., 2006, Kang and Ryoo, 2007, Kang and Ryoo, 2008, Ryoo and Steller, 2007, Ryoo et al., 2007, Carbone et al., 2009, Mendes et al., 2009, Arsham and Neufeld, 2009, Bronstein et al., 2010, Chang et al., 2011) Xbp1 (Farkas et al., 2007, FlyBase Curators, 2008, Buszczak et al., 2007, Fox et al., 2008, Farkas et al., 2008, Christensen et al., 2008.4.15, Johansson et al., 2007, Ida et al., 2009, Arsham and Neufeld, 2009, Liu et al., 2009, Greene et al., 2005, Loewen and Feany, 2010, Ryoo et al., 2007, FlyBase Genome Annotators, 2007) XBP-1 (Hollien and Weissman, 2006) XBP1 (Plongthongkum et al., 2007) xbp-1 (Haecker et al., 2008, Kang and Ryoo, 2009) Xbp-1 (Ida et al., 2009)
Name Synonym	X-box binding protein (Plongthongkum et al., 2007) X box binding protein-1 (Spradling et al., 1999) X-box-binding protein 1 (Hollien and Weissman, 2006) X box binding protein 1 (Ida et al., 2009)
Secondary FlyBase IDs
	FBgn0025990 FBgn0034593
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 7 ) FlyBase analysis  ( 4 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Bronstein et al., 2010, PLoS Genet. 6(8): e1001063 Transcriptional regulation by CHIP/LDB complexes. [FBrf0211594] Loewen and Feany, 2010, PLoS ONE 5(9): e13084 The unfolded protein response protects from tau neurotoxicity in vivo. [FBrf0211994] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...