• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\l(2)k09913

General Information
Symbol	Dmel\l(2)k09913	Species	D. melanogaster
Name	lethal (2) k09913	Annotation symbol	CG3082
Feature type	protein_coding_gene	FlyBase ID	FBgn0021979
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	59C3-59C3	Sequence location	2R:18,954,725..18,959,404 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) k09913 is referred to in FlyBase by the symbol Dmel\l(2)k09913 (CG3082, FBgn0021979). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 9 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Protein of unknown function DUF829, TMEM53. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1631028_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of l(2)k09913. Gene sequence location is 2R:18954725..18959404.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA04699 BKN31771
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59C3-59C3   Limits computationally determined from genome sequence between P{PZ}l(2)0649606496&P{lacW}l(2)k09913k09913 and P{lacW}l(2)k07136k07136
Experimentally Determined Cytological Location
Cytogenetic map Notes References 59C3-59C5   (determined by in situ hybridisation)   (Spradling et al., 1999) 59C3-59C5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)k09913 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Only one EST supports this alternative transcript
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)k09913-RA FBtr0071959  NM_166582   1900   389 l(2)k09913-RB FBtr0071958  NM_166583   1691   389 l(2)k09913-RC FBtr0071960  NM_137907   1969   389 l(2)k09913-RD FBtr0071961  NM_166584   1457   316
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)k09913-PA   FBpp0071870   44.2   389   9.89     NP_726284   AAF46947 l(2)k09913-PB   FBpp0071869   44.2   389   9.89     NP_726285   AAF46948 l(2)k09913-PC   FBpp0071871   44.2   389   9.89     NP_611751   AAF46949 l(2)k09913-PD   FBpp0071872   36.6   316   9.80     NP_726286   AAM68234
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF829, TMEM53 (IPR008547)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201443   AA201854   AA202403   AA202500   AA263844   AA263986   AA264407   AA440719   AA440984   AA567731   AA568048   AA820846   AA940764   AA941072   AA941168   AA941250   AA941404   AA942393   AA979017   AE013599 AAF46947   AE013599 AAF46948   AE013599 AAF46949   AE013599 AAM68234   AI062062   AI063869   AI063892   AI113881   AI134664   AI135914   AI259060   AI259547   AI296122   AI387886   AI388390   AI389797   AI403351   AI403439   AI455922   AI456606   AI456762   AI456843   AI457055   AI515853   AI518376   AI533135   AI533913   AQ025910   AW942367   AY061202 AAL28750   BG633057   BG638816   BG641105   BI161531   BI166031   BI166899   BI212696   BI212785   BI214058   BI232741   BI239429   BI240231   BI240386   BI242803   BI370596   BI372377   BI485242   BI564142   BI564206   BI568855   BI568856   BI570619   BI570984   BI586809   BI589936   BI590546   BI591440   BI592342   BI606641   BI613077   BI613101   BI615388   BI615818   BI616137   BI617207   BI617412   BI618962   BI622520   BI623894   BI625152   BI627654   BI628594   BI628983   BI630378   BI634854   BI635973   BI639120   BI639434   BI639541   BP554193   BP554194   BT001813 AAN71568   CA806153   CK659054   CK659280   CO155806   CO187203   CO264609   CO265997   CO284923   CO288413   CO296069   CO297857   CO299286   CO302284   CO304898   CO306194   CO310160   CO324083   CO337448   CO341530   CZ478586   EC061032   EC064615   EC070326   EC085596   EC196215   EC198493   EC201695   EC210366   EC229894   EC233100   EC234530   EC241212   EC247188   EC253482   EC262644   EC266119   EC267536   EL871959   EL871960   EL880292   EL880293   EL881948   EL881949   EL882181   EL882182   ES693306   ES693315   ES693342   ES693344   ES693355   ES693360   ES693367   ES693394   ES693410   ES693432   ES693479   ES693508   ES693527   ES693529   ES693534   ES693537   ES693540   ES693547   ES693657   ES693681   ES693703   ES693743   ES693808   ES693834   ES693838   ES693848   ES693850   ES693860   ES693862   ES693863   ES693902   ES693926   ES693929   ES693947   ES693951   ES693975   ES693987   ES693991   ES693998   ES694022   ES694046   ES694050   ES694072   ES694076   ES694078   ES694104   ES694120
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MLS7 Q7K274
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0021979    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0021979 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0021979 expression level Developmental Stage   Expression Level embryo 00-02hr    7553 embryo 02-04hr    9989 embryo 04-06hr    5961 embryo 06-08hr    4239 embryo 08-10hr    4827 embryo 10-12hr    5143 embryo 12-14hr    3881 embryo 14-16hr    4461 embryo 16-18hr    3345 embryo 18-20hr    3760 embryo 20-22hr    4068 embryo 22-24hr    3374 larva L1    1911 larva L2    2170 larva L3 12hr old    2889 larva L3 puffstage 1-2    5088 larva L3 puffstage 3-6    5864 larva L3 puffstage 7-9    6274 white prepupae new    6298 white prepupae 12hr    5742 white prepupae 24hr    7824 pupae 2d postWPP    8191 pupae 3d postWPP    6487 pupae 4d postWPP    5521 adult male 01day    5866 adult male 05day    5560 adult male 30day    4928 adult female 01day    5743 adult female 05day    4941 adult female 30day    5245 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7553) embryo 02-04hr  (9989) embryo 04-06hr  (5961) embryo 06-08hr  (4239) embryo 08-10hr  (4827) embryo 10-12hr  (5143) embryo 12-14hr  (3881) embryo 14-16hr  (4461) embryo 16-18hr  (3345) embryo 18-20hr  (3760) embryo 20-22hr  (4068) embryo 22-24hr  (3374) larva L1  (1911) larva L2  (2170) larva L3 12hr old  (2889) larva L3 puffstage 1-2  (5088) larva L3 puffstage 3-6  (5864) larva L3 puffstage 7-9  (6274) white prepupae new  (6298) white prepupae 12hr  (5742) white prepupae 24hr  (7824) pupae 2d postWPP  (8191) pupae 3d postWPP  (6487) pupae 4d postWPP  (5521) adult male 01day  (5866) adult male 05day  (5560) adult male 30day  (4928) adult female 01day  (5743) adult female 05day  (4941) adult female 30day  (5245) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7553) embryo 02-04hr  (9989) embryo 04-06hr  (5961) embryo 06-08hr  (4239) embryo 08-10hr  (4827) embryo 10-12hr  (5143) embryo 12-14hr  (3881) embryo 14-16hr  (4461) embryo 16-18hr  (3345) embryo 18-20hr  (3760) embryo 20-22hr  (4068) embryo 22-24hr  (3374) larva L1  (1911) larva L2  (2170) larva L3 12hr old  (2889) larva L3 puffstage 1-2  (5088) larva L3 puffstage 3-6  (5864) larva L3 puffstage 7-9  (6274) white prepupae new  (6298) white prepupae 12hr  (5742) white prepupae 24hr  (7824) pupae 2d postWPP  (8191) pupae 3d postWPP  (6487) pupae 4d postWPP  (5521) adult male 01day  (5866) adult male 05day  (5560) adult male 30day  (4928) adult female 01day  (5743) adult female 05day  (4941) adult female 30day  (5245) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7553 embryo 02-04hr    9989 embryo 04-06hr    5961 embryo 06-08hr    4239 embryo 08-10hr    4827 embryo 10-12hr    5143 embryo 12-14hr    3881 embryo 14-16hr    4461 embryo 16-18hr    3345 embryo 18-20hr    3760 embryo 20-22hr    4068 embryo 22-24hr    3374 larva L1    1911 larva L2    2170 larva L3 12hr old    2889 larva L3 puffstage 1-2    5088 larva L3 puffstage 3-6    5864 larva L3 puffstage 7-9    6274 white prepupae new    6298 white prepupae 12hr    5742 white prepupae 24hr    7824 pupae 2d postWPP    8191 pupae 3d postWPP    6487 pupae 4d postWPP    5521 adult male 01day    5866 adult male 05day    5560 adult male 30day    4928 adult female 01day    5743 adult female 05day    4941 adult female 30day    5245 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7553 embryo 02-04hr    9989 embryo 04-06hr    5961 embryo 06-08hr    4239 embryo 08-10hr    4827 embryo 10-12hr    5143 embryo 12-14hr    3881 embryo 14-16hr    4461 embryo 16-18hr    3345 embryo 18-20hr    3760 embryo 20-22hr    4068 embryo 22-24hr    3374 larva L1    1911 larva L2    2170 larva L3 12hr old    2889 larva L3 puffstage 1-2    5088 larva L3 puffstage 3-6    5864 larva L3 puffstage 7-9    6274 white prepupae new    6298 white prepupae 12hr    5742 white prepupae 24hr    7824 pupae 2d postWPP    8191 pupae 3d postWPP    6487 pupae 4d postWPP    5521 adult male 01day    5866 adult male 05day    5560 adult male 30day    4928 adult female 01day    5743 adult female 05day    4941 adult female 30day    5245 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0021979 expression level Developmental Stage   Expression Level embryo 00-02hr    7553 embryo 02-04hr    9989 embryo 04-06hr    5961 embryo 06-08hr    4239 embryo 08-10hr    4827 embryo 10-12hr    5143 embryo 12-14hr    3881 embryo 14-16hr    4461 embryo 16-18hr    3345 embryo 18-20hr    3760 embryo 20-22hr    4068 embryo 22-24hr    3374 larva L1    1911 larva L2    2170 larva L3 12hr old    2889 larva L3 puffstage 1-2    5088 larva L3 puffstage 3-6    5864 larva L3 puffstage 7-9    6274 white prepupae new    6298 white prepupae 12hr    5742 white prepupae 24hr    7824 pupae 2d postWPP    8191 pupae 3d postWPP    6487 pupae 4d postWPP    5521 adult male 01day    5866 adult male 05day    5560 adult male 30day    4928 adult female 01day    5743 adult female 05day    4941 adult female 30day    5245 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7553) embryo 02-04hr  (9989) embryo 04-06hr  (5961) embryo 06-08hr  (4239) embryo 08-10hr  (4827) embryo 10-12hr  (5143) embryo 12-14hr  (3881) embryo 14-16hr  (4461) embryo 16-18hr  (3345) embryo 18-20hr  (3760) embryo 20-22hr  (4068) embryo 22-24hr  (3374) larva L1  (1911) larva L2  (2170) larva L3 12hr old  (2889) larva L3 puffstage 1-2  (5088) larva L3 puffstage 3-6  (5864) larva L3 puffstage 7-9  (6274) white prepupae new  (6298) white prepupae 12hr  (5742) white prepupae 24hr  (7824) pupae 2d postWPP  (8191) pupae 3d postWPP  (6487) pupae 4d postWPP  (5521) adult male 01day  (5866) adult male 05day  (5560) adult male 30day  (4928) adult female 01day  (5743) adult female 05day  (4941) adult female 30day  (5245) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7553) embryo 02-04hr  (9989) embryo 04-06hr  (5961) embryo 06-08hr  (4239) embryo 08-10hr  (4827) embryo 10-12hr  (5143) embryo 12-14hr  (3881) embryo 14-16hr  (4461) embryo 16-18hr  (3345) embryo 18-20hr  (3760) embryo 20-22hr  (4068) embryo 22-24hr  (3374) larva L1  1911 larva L2  2170 larva L3 12hr old  (2889) larva L3 puffstage 1-2  (5088) larva L3 puffstage 3-6  (5864) larva L3 puffstage 7-9  (6274) white prepupae new  (6298) white prepupae 12hr  (5742) white prepupae 24hr  (7824) pupae 2d postWPP  (8191) pupae 3d postWPP  (6487) pupae 4d postWPP  (5521) adult male 01day  (5866) adult male 05day  (5560) adult male 30day  (4928) adult female 01day  (5743) adult female 05day  (4941) adult female 30day  (5245) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7553 embryo 02-04hr    9989 embryo 04-06hr    5961 embryo 06-08hr    4239 embryo 08-10hr    4827 embryo 10-12hr    5143 embryo 12-14hr    3881 embryo 14-16hr    4461 embryo 16-18hr    3345 embryo 18-20hr    3760 embryo 20-22hr    4068 embryo 22-24hr    3374 larva L1    1911 larva L2    2170 larva L3 12hr old    2889 larva L3 puffstage 1-2    5088 larva L3 puffstage 3-6    5864 larva L3 puffstage 7-9    6274 white prepupae new    6298 white prepupae 12hr    5742 white prepupae 24hr    7824 pupae 2d postWPP    8191 pupae 3d postWPP    6487 pupae 4d postWPP    5521 adult male 01day    5866 adult male 05day    5560 adult male 30day    4928 adult female 01day    5743 adult female 05day    4941 adult female 30day    5245 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7553 embryo 02-04hr    9989 embryo 04-06hr    5961 embryo 06-08hr    4239 embryo 08-10hr    4827 embryo 10-12hr    5143 embryo 12-14hr    3881 embryo 14-16hr    4461 embryo 16-18hr    3345 embryo 18-20hr    3760 embryo 20-22hr    4068 embryo 22-24hr    3374 larva L1    1911 larva L2    2170 larva L3 12hr old    2889 larva L3 puffstage 1-2    5088 larva L3 puffstage 3-6    5864 larva L3 puffstage 7-9    6274 white prepupae new    6298 white prepupae 12hr    5742 white prepupae 24hr    7824 pupae 2d postWPP    8191 pupae 3d postWPP    6487 pupae 4d postWPP    5521 adult male 01day    5866 adult male 05day    5560 adult male 30day    4928 adult female 01day    5743 adult female 05day    4941 adult female 30day    5245 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0021979    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0021979 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0021979 expression level Tissue   Expression Level Larval Central Nervous System    958.025 Larval Midgut    903.4 Larval Hindgut    694.2 Larval Malpighian Tubules    800.6 Larval Fat Body    1821.7 Larval Salivary Gland    585.2 Larval Trachea    1087.475 Larval Carcass    728.4 Adult Head    1456.7 Adult Eye    2772.95 Adult Brain    1342 Adult Thoracic-Abdominal Ganglion    1875.2 Adult Crop    1108.9 Adult Midgut    965.3 Adult Hindgut    790.9 Adult Malpighian Tubules    1255.2 Adult Fat Body    1386.4 Adult Salivary Gland    680.9 Adult Heart    1598.35 Adult VirginFemale Spermatheca    1776.5 Adult InseminatedFemale Spermatheca    1642.3 Adult Ovary    528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass    939.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (958.025) Larval Midgut  (903.4) Larval Hindgut  (694.2) Larval Malpighian Tubules  (800.6) Larval Fat Body  (1821.7) Larval Salivary Gland  (585.2) Larval Trachea  (1087.475) Larval Carcass  (728.4) Adult Head  (1456.7) Adult Eye  (2772.95) Adult Brain  (1342) Adult Thoracic-Abdominal Ganglion  (1875.2) Adult Crop  (1108.9) Adult Midgut  (965.3) Adult Hindgut  (790.9) Adult Malpighian Tubules  (1255.2) Adult Fat Body  (1386.4) Adult Salivary Gland  (680.9) Adult Heart  (1598.35) Adult VirginFemale Spermatheca  (1776.5) Adult InseminatedFemale Spermatheca  (1642.3) Adult Ovary  528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass  (939.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    958.025 Larval Midgut    903.4 Larval Hindgut    694.2 Larval Malpighian Tubules    800.6 Larval Fat Body  (1821.7) Larval Salivary Gland    585.2 Larval Trachea  (1087.475) Larval Carcass    728.4 Adult Head  (1456.7) Adult Eye  (2772.95) Adult Brain  (1342) Adult Thoracic-Abdominal Ganglion  (1875.2) Adult Crop  (1108.9) Adult Midgut    965.3 Adult Hindgut    790.9 Adult Malpighian Tubules  (1255.2) Adult Fat Body  (1386.4) Adult Salivary Gland    680.9 Adult Heart  (1598.35) Adult VirginFemale Spermatheca  (1776.5) Adult InseminatedFemale Spermatheca  (1642.3) Adult Ovary    528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass    939.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    958.025 Larval Midgut    903.4 Larval Hindgut    694.2 Larval Malpighian Tubules    800.6 Larval Fat Body    1821.7 Larval Salivary Gland    585.2 Larval Trachea    1087.475 Larval Carcass    728.4 Adult Head    1456.7 Adult Eye    2772.95 Adult Brain    1342 Adult Thoracic-Abdominal Ganglion    1875.2 Adult Crop    1108.9 Adult Midgut    965.3 Adult Hindgut    790.9 Adult Malpighian Tubules    1255.2 Adult Fat Body    1386.4 Adult Salivary Gland    680.9 Adult Heart    1598.35 Adult VirginFemale Spermatheca    1776.5 Adult InseminatedFemale Spermatheca    1642.3 Adult Ovary    528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass    939.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0021979 expression level Tissue   Expression Level Larval Central Nervous System    958.025 Larval Midgut    903.4 Larval Hindgut    694.2 Larval Malpighian Tubules    800.6 Larval Fat Body    1821.7 Larval Salivary Gland    585.2 Larval Trachea    1087.475 Larval Carcass    728.4 Adult Head    1456.7 Adult Eye    2772.95 Adult Brain    1342 Adult Thoracic-Abdominal Ganglion    1875.2 Adult Crop    1108.9 Adult Midgut    965.3 Adult Hindgut    790.9 Adult Malpighian Tubules    1255.2 Adult Fat Body    1386.4 Adult Salivary Gland    680.9 Adult Heart    1598.35 Adult VirginFemale Spermatheca    1776.5 Adult InseminatedFemale Spermatheca    1642.3 Adult Ovary    528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass    939.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (958.025) Larval Midgut  (903.4) Larval Hindgut  694.2 Larval Malpighian Tubules  800.6 Larval Fat Body  (1821.7) Larval Salivary Gland  585.2 Larval Trachea  (1087.475) Larval Carcass  728.4 Adult Head  (1456.7) Adult Eye  (2772.95) Adult Brain  (1342) Adult Thoracic-Abdominal Ganglion  (1875.2) Adult Crop  (1108.9) Adult Midgut  (965.3) Adult Hindgut  790.9 Adult Malpighian Tubules  (1255.2) Adult Fat Body  (1386.4) Adult Salivary Gland  680.9 Adult Heart  (1598.35) Adult VirginFemale Spermatheca  (1776.5) Adult InseminatedFemale Spermatheca  (1642.3) Adult Ovary  528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass  (939.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    958.025 Larval Midgut    903.4 Larval Hindgut    694.2 Larval Malpighian Tubules    800.6 Larval Fat Body  (1821.7) Larval Salivary Gland    585.2 Larval Trachea  1087.475 Larval Carcass    728.4 Adult Head  1456.7 Adult Eye  (2772.95) Adult Brain  1342 Adult Thoracic-Abdominal Ganglion  (1875.2) Adult Crop  1108.9 Adult Midgut    965.3 Adult Hindgut    790.9 Adult Malpighian Tubules  1255.2 Adult Fat Body  1386.4 Adult Salivary Gland    680.9 Adult Heart  1598.35 Adult VirginFemale Spermatheca  (1776.5) Adult InseminatedFemale Spermatheca  1642.3 Adult Ovary    528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass    939.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    958.025 Larval Midgut    903.4 Larval Hindgut    694.2 Larval Malpighian Tubules    800.6 Larval Fat Body    1821.7 Larval Salivary Gland    585.2 Larval Trachea    1087.475 Larval Carcass    728.4 Adult Head    1456.7 Adult Eye    2772.95 Adult Brain    1342 Adult Thoracic-Abdominal Ganglion    1875.2 Adult Crop    1108.9 Adult Midgut    965.3 Adult Hindgut    790.9 Adult Malpighian Tubules    1255.2 Adult Fat Body    1386.4 Adult Salivary Gland    680.9 Adult Heart    1598.35 Adult VirginFemale Spermatheca    1776.5 Adult InseminatedFemale Spermatheca    1642.3 Adult Ovary    528.2 Adult Testis    186.8 Adult Male Accessory Gland    371.4 Adult Carcass    939.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1456.7   NA  Eye    2772.95   NA  Brain    1342   958.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1875.2   NA  Crop    1108.9   903.4  Midgut    965.3   694.2  Hindgut    790.9   800.6  Malpighian Tubules    1255.2   1821.7  Fat Body    1386.4   585.2  Salivary Gland    680.9   NA  Heart    1598.35   1087.475  Trachea    NA   NA  VirginFemale Spermatheca    1776.5   NA  InseminatedFemale Spermatheca    1642.3   NA  Ovary    528.2   NA  Testis    186.8   NA  Male Accessory Gland    371.4   728.4  Carcass    939.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021979 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3082-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for l(2)k09913 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive l(2)k09913k09913 Phenotype manifest in Allele
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of l(2)k09913 Class Mutagen Stocks Known lesion l(2)k09913k09913 P-element activity 2 -- l(2)k09913CB-5617-3 1 -- l(2)k09913e00736 piggyBac transposase 1 -- l(2)k09913e03946 1 -- l(2)k09913EY20574 P-element activity 1 -- l(2)k09913G18923 P-element activity 1 -- l(2)k09913NP0009 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)k09913 Class Mutagen Stocks Known lesion l(2)k09913KK111771 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)k09913GD4546 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)59AD (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)bwVDe2LPxKR (Spradling et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4546} NA P{KK111771} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)k09913k09913 No P{lacW}l(2)SH1719SH1719 No miscellaneous insertions P{RS3}l(2)k09913CB-5617-3 NA PBac{RB}l(2)k09913e00736 NA PBac{RB}l(2)k09913e03946 NA insertion of enhancer trap binary system P{GawB}l(2)k09913NP0009 No insertion of mobile activating element P{EP}l(2)k09913G18923 NA P{EPgy2}l(2)k09913EY20574 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)k09913 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63267 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0021979 DroID - A comprehensive database of gene and protein interactions. • FBgn0021979 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37661
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13561 Dere\l(2)k09913 Dgri\GH20830 Dmoj\GI20930 Dper\GL11302 Dpse\GA15913 Dsec\GM15981 Dsim\GD11735 Dvir\GJ20657 Dwil\GK19549 Dyak\l(2)k09913
Curated drosophilid orthologs	Dere\l(2)k09913   Dpse\GA15913   Dsim\l(2)k09913 (Swanson et al., 2001) Dyak\l(2)k09913
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008734-PA Aedes aegypti (mosquito) AGAP011464-PA Anopheles gambiae (mosquito) XP_624941.1 Apis mellifera (honey bee) At5g44250.1 Arabidopsis thaliana (wall cress) 122204 Branchiostoma floridae (lancelet) 82341 Branchiostoma floridae (lancelet) BGIBMGA009220-PA Bombyx mori (silk worm) ENSBTAP00000042597 Bos taurus (bovine) CPIJ006220 Culex pipens (mosquito) 151990 Capitella spl (polychaete worm) ENSDARP00000075652 Danio rerio (zebra fish) ENSGACP00000016662 Gymnopilus aculeatus (mushroom) 168792 Hypsipyla robusta (cedar shoot borer) ISCW023976-PA Ixodes scapularis (deer tick) 121859 Lottia gigantea (owl limpet) 27002 Monocosta brevicollis (choanoflagellate) XP_001606567.1 Nasonia vitripennis (wasp) LOC_Os11g40070.1 Oryza sativa (asian rice) PHUM002317-PA Pediculus humanus (human body louse) XP_001178118.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974475.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013948 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033870 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14504 LH17916 ISCW023976 ISCW005373 FBgn0067957 FBgn0221547 FBgn0207795 FBgn0183474 FBgn0170897 FBgn0075929 FBgn0148911 FBgn0143664 FBgn0128292 FBgn0064603 FBgn0090590 CPIJ006220 BGIBMGA009219 BGIBMGA009220 BGIBMGA009218 GB10512 AGAP011464 AGAP011465 AAEL008734 PB20651 PHUM291270 GLEAN_07567
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	22399 y1 w67c23; P{EPgy2}l(2)k09913EY20574 12194 y1 w67c23; P{lacW}l(2)k09913k09913/CyO 26948 y1 w*; P{EP}CG42640G18923 l(2)k09913G18923
Harvard	- PBac{RB}l(2)k09913e00736 - PBac{RB}l(2)k09913e03946
Kyoto	123715 w1118; P{RS3}l(2)k09913CB-5617-3 103493 y* w*; P{GawB}l(2)k09913NP0009 / CyO, P{UAS-lacZ.UW14}UW14 111440 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}l(2)k09913k09913 /CyO y+
VDRC	v102477 P{KK111771}VIE-260B
Genomic Clones ( 2 )
	BACR08P09 BACR37H13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 131 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15586 RH35959
Other clones	DPiM_LD15586 DPiM_RH35959
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01114 GH03974 GH04002 GH10372 GH12189 GH13836 GH18569 GH21060 GH22771 GH22874 HL01223 HL01691 LD01994 LD02574 LD03771 LD04471 LD07080 LD07353 LD08058 LD10329 LD22988 LD24757 LD25026 LD25155 LD25285 LD25533 LD26571 LD33256 LD35656 LD36682 LD36883 LD37278 LD37867 LD41540 LP02383 LP02982 LP09940 LP16504 LP16933 RE01031 RE06050 RE07144 RE17828 RE18112 RE19757 RE28862 RE35913 RE36929 RE37225 RE40235 RE57286 RE59326 RE68540 RH03462 RH04181 RH05216 RH05380 RH05787 RH09991 RH26915 RH35859 RH39103 RH42149 RH42175 RH45001 RH45647 RH46008 RH47468 RH47740 RH49915 RH54409 RH56255 RH57072 RH57763 RH59410 RH65143 RH69021 RH73249 SD04856 SD05908 SD12350 SD17524 SD21572 SD22008 SD22148
Other clones	15990 16815 30610 34858 55708 57149 74056 80296 97843 214345.64 521769 525600 569118 CK01.52B.G3 CK01.57D.G7 CK01.86D.E4 CK01.92B.C4 EK027201 EK068450 EK139724 EK144640 EK167601 EK170753 EK175016 EK183824 EK192505 EK212624 EK220623 EK246702 EK250504 EN06760 EN14556 EP12621 ESG012a.E21_H04 FGM228E08 GH19287 IP03966 IP10125 IP11754 IP11954 LD36990 RH01141
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0021979 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37661
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137907 NM_166582 NM_166583 NM_166584 RefSeq (Proteins) • NP_611751 NP_726284 NP_726285 NP_726286 DDBJ / EMBL / GenBank • AA263986 AA440719 AAF46947 AAF46948 AAF46949 AAL28750 AAM68234 AAN71568 AQ025910 AW942367 AY061202 BI564206 BT001813 CZ478586 Entrez Gene - A searchable database of RefSeq genes. • 37661 UniProtKB/TrEMBL • Q7K274 Q8MLS7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF829, TMEM53 (IPR008547)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63267 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0021979 DroID - A comprehensive database of gene and protein interactions. • FBgn0021979 DRSC - Results from RNAi screens. • FBgn0021979 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021979 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3082-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0021979 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37661 InParanoid A subset of ortholog calls from InParanoid. • AAEL008734-PA Aedes aegypti (mosquito) AGAP011464-PA Anopheles gambiae (mosquito) XP_624941.1 Apis mellifera (honey bee) At5g44250.1 Arabidopsis thaliana (wall cress) 122204 Branchiostoma floridae (lancelet) 82341 Branchiostoma floridae (lancelet) BGIBMGA009220-PA Bombyx mori (silk worm) ENSBTAP00000042597 Bos taurus (bovine) CPIJ006220 Culex pipens (mosquito) 151990 Capitella spl (polychaete worm) ENSDARP00000075652 Danio rerio (zebra fish) ENSGACP00000016662 Gymnopilus aculeatus (mushroom) 168792 Hypsipyla robusta (cedar shoot borer) ISCW023976-PA Ixodes scapularis (deer tick) 121859 Lottia gigantea (owl limpet) 27002 Monocosta brevicollis (choanoflagellate) XP_001606567.1 Nasonia vitripennis (wasp) LOC_Os11g40070.1 Oryza sativa (asian rice) PHUM002317-PA Pediculus humanus (human body louse) XP_001178118.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974475.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013948 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033870 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37661 modMine - Data generated by the modENCODE project. • FBgn0021979 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14504 LH17916 ISCW023976 ISCW005373 FBgn0067957 FBgn0221547 FBgn0207795 FBgn0183474 FBgn0170897 FBgn0075929 FBgn0148911 FBgn0143664 FBgn0128292 FBgn0064603 FBgn0090590 CPIJ006220 BGIBMGA009219 BGIBMGA009220 BGIBMGA009218 GB10512 AGAP011464 AGAP011465 AAEL008734 PB20651 PHUM291270 GLEAN_07567
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	1(2)k09913 (Domazet-Loso and Tautz, 2003) CG3082 (Keleman et al., 2009.8.5, Cammarato et al., 2011) l(2)k09913 (Nelson et al., 2005, Telonis-Scott et al., 2009, Juhasz et al., 2007)
Name Synonym	lethal (2) k09913 (Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 3 ) FlyBase analysis  ( 1 ) Computer file  ( 4 )
Recent research papers ( 1 )
	Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Show all research papers ...