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Gene Dmel\Rs1

General Information
Symbol	Dmel\Rs1	Species	D. melanogaster
Name	Rs1	Annotation symbol	CG2173
Feature type	protein_coding_gene	FlyBase ID	FBgn0021995
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(2)k09514
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44B7-44B7	Sequence location	2R:4,052,385..4,055,274 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rs1 is referred to in FlyBase by the symbol Dmel\Rs1 (CG2173, FBgn0021995). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent RNA helicase activity; RNA helicase activity. It is reported to be involved in the biological process: ribosome biogenesis. 6 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; RNA helicase, ATP-dependent, DEAD-box, conserved site; RNA helicase, DEAD-box type, Q motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631198_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rs1. Gene sequence location is 2R:4052385..4055274.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44B7-44B7   Limits computationally determined from genome sequence between P{EP}kermitEP493 and P{lacW}Rs1k09514&P{lacW}l(2)k03110k03110
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44C1-44C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 44B7-44B8     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rs1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rs1-RA FBtr0088788  NM_143713   2527   782
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rs1-PA   FBpp0087865   87.8   782   10.14     NP_651970   AAF59119
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202806   AA263900   AA440636   AA695461   AA696215   AA803658   AA816344   AA938832   AE013599 AAF59119   AF181659 AAD55444   AI455736   AQ025895   AW942361   BI161951   BI161952   BI165919   BI165931   BI168459   BI169508   BI173416   BI230399   BI354021   BI358075   BI366216   BI374215   BI580049   BI639696   BT004908 AAO49161   CO276434   CO303298   CO328766   CO341161   CO342829   EC052063   EC055086   EC056627   EC060030   EC078799   EC226037   EC235936   EC253449   EC259498
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JQN4 Q7KK34
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium somatic muscle primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    166.475 Larval Midgut    68.8 Larval Hindgut    78.3 Larval Malpighian Tubules    36.8 Larval Fat Body    40.6 Larval Salivary Gland    106.5 Larval Trachea    129.375 Larval Carcass    111.475 Adult Head    66.4 Adult Eye    65.4 Adult Brain    54.7 Adult Thoracic-Abdominal Ganglion    63.2 Adult Crop    80.4 Adult Midgut    64.6 Adult Hindgut    61.5 Adult Malpighian Tubules    76.2 Adult Fat Body    97.3 Adult Salivary Gland    113.3 Adult Heart    146.125 Adult VirginFemale Spermatheca    101.6 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    211 Adult Testis    34.4 Adult Male Accessory Gland    173.1 Adult Carcass    63.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    66.4   NA  Eye    65.4   NA  Brain    54.7   166.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    63.2   NA  Crop    80.4   68.8  Midgut    64.6   78.3  Hindgut    61.5   36.8  Malpighian Tubules    76.2   40.6  Fat Body    97.3   106.5  Salivary Gland    113.3   NA  Heart    146.125   129.375  Trachea    NA   NA  VirginFemale Spermatheca    101.6   NA  InseminatedFemale Spermatheca    140.5   NA  Ovary    211   NA  Testis    34.4   NA  Male Accessory Gland    173.1   111.475  Carcass    63.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    35 testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (35) testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    35 testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    35 testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    35 testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (35) testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    35 testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    11 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    6 digestive system, 4-day adult    14 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    12 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    35 testis, mated 4-day male    9 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    69 embryo 04-06hr    77 embryo 06-08hr    69 embryo 08-10hr    61 embryo 10-12hr    58 embryo 12-14hr    38 embryo 14-16hr    30 embryo 16-18hr    26 embryo 18-20hr    18 embryo 20-22hr    51 embryo 22-24hr    41 larva L1    60 larva L2    30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day    33 adult female 05day    38 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (39) embryo 02-04hr  (69) embryo 04-06hr  (77) embryo 06-08hr  (69) embryo 08-10hr  (61) embryo 10-12hr  (58) embryo 12-14hr  (38) embryo 14-16hr  (30) embryo 16-18hr  26 embryo 18-20hr    18 embryo 20-22hr  (51) embryo 22-24hr  (41) larva L1  (60) larva L2  (30) larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day  (33) adult female 05day  (38) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    69 embryo 04-06hr    77 embryo 06-08hr    69 embryo 08-10hr    61 embryo 10-12hr    58 embryo 12-14hr    38 embryo 14-16hr    30 embryo 16-18hr    26 embryo 18-20hr    18 embryo 20-22hr    51 embryo 22-24hr    41 larva L1    60 larva L2    30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day    33 adult female 05day    38 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    69 embryo 04-06hr    77 embryo 06-08hr    69 embryo 08-10hr    61 embryo 10-12hr    58 embryo 12-14hr    38 embryo 14-16hr    30 embryo 16-18hr    26 embryo 18-20hr    18 embryo 20-22hr    51 embryo 22-24hr    41 larva L1    60 larva L2    30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day    33 adult female 05day    38 adult female 30day    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    69 embryo 04-06hr    77 embryo 06-08hr    69 embryo 08-10hr    61 embryo 10-12hr    58 embryo 12-14hr    38 embryo 14-16hr    30 embryo 16-18hr    26 embryo 18-20hr    18 embryo 20-22hr    51 embryo 22-24hr    41 larva L1    60 larva L2    30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day    33 adult female 05day    38 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (39) embryo 02-04hr  (69) embryo 04-06hr  (77) embryo 06-08hr  (69) embryo 08-10hr  (61) embryo 10-12hr  (58) embryo 12-14hr  (38) embryo 14-16hr  30 embryo 16-18hr  26 embryo 18-20hr    18 embryo 20-22hr  (51) embryo 22-24hr  (41) larva L1  (60) larva L2  30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day  (33) adult female 05day  (38) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    69 embryo 04-06hr    77 embryo 06-08hr    69 embryo 08-10hr    61 embryo 10-12hr    58 embryo 12-14hr    38 embryo 14-16hr    30 embryo 16-18hr    26 embryo 18-20hr    18 embryo 20-22hr    51 embryo 22-24hr    41 larva L1    60 larva L2    30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day    33 adult female 05day    38 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    69 embryo 04-06hr    77 embryo 06-08hr    69 embryo 08-10hr    61 embryo 10-12hr    58 embryo 12-14hr    38 embryo 14-16hr    30 embryo 16-18hr    26 embryo 18-20hr    18 embryo 20-22hr    51 embryo 22-24hr    41 larva L1    60 larva L2    30 larva L3 12hr old    20 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    7 adult female 01day    33 adult female 05day    38 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    31 embryonic GM2    33 embryonic Kc167    62 embryonic S1    30 embryonic S3    30 leg disc CME L1    54 wing disc CME-W2    58 wing disc ML-DmD8    28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    21 ovary fGS/OSS    39 ovary OSC    34 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4  (60) embryonic 1182-4H  (31) embryonic GM2  (33) embryonic Kc167  (62) embryonic S1  (30) embryonic S3  (30) leg disc CME L1  (54) wing disc CME-W2  (58) wing disc ML-DmD8  (28) wing disc ML-DmD9    25 wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (61) wing disc ML-DmD32  (46) haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (32) antennal disc ML-DmD20-c5  (30) mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (49) CNS ML-DmBG2-c2  (47) tumorous blood cells mbn2    21 ovary fGS/OSS  (39) ovary OSC  (34) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    31 embryonic GM2    33 embryonic Kc167    62 embryonic S1    30 embryonic S3    30 leg disc CME L1    54 wing disc CME-W2    58 wing disc ML-DmD8    28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    21 ovary fGS/OSS    39 ovary OSC    34 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    31 embryonic GM2    33 embryonic Kc167    62 embryonic S1    30 embryonic S3    30 leg disc CME L1    54 wing disc CME-W2    58 wing disc ML-DmD8    28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    21 ovary fGS/OSS    39 ovary OSC    34 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    31 embryonic GM2    33 embryonic Kc167    62 embryonic S1    30 embryonic S3    30 leg disc CME L1    54 wing disc CME-W2    58 wing disc ML-DmD8    28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    21 ovary fGS/OSS    39 ovary OSC    34 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4  (60) embryonic 1182-4H  31 embryonic GM2  (33) embryonic Kc167  (62) embryonic S1  30 embryonic S3  30 leg disc CME L1  (54) wing disc CME-W2  (58) wing disc ML-DmD8  28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (61) wing disc ML-DmD32  (46) haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  32 antennal disc ML-DmD20-c5  30 mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (49) CNS ML-DmBG2-c2  (47) tumorous blood cells mbn2    21 ovary fGS/OSS  (39) ovary OSC  (34) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    31 embryonic GM2    33 embryonic Kc167    62 embryonic S1    30 embryonic S3    30 leg disc CME L1    54 wing disc CME-W2    58 wing disc ML-DmD8    28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    21 ovary fGS/OSS    39 ovary OSC    34 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    31 embryonic GM2    33 embryonic Kc167    62 embryonic S1    30 embryonic S3    30 leg disc CME L1    54 wing disc CME-W2    58 wing disc ML-DmD8    28 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    21 ovary fGS/OSS    39 ovary OSC    34 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD15481 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021995 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2173-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rs1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Rs1k09513 Rs1k09514 viable, with Scer\GAL4pnr-MD237 Rs1GD14790 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Rs1GD14790 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Rs1GD14790
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Rs1 Class Mutagen Stocks Known lesion Rs1k09514 P-element activity 2 -- Rs1k09513 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rs1 Class Mutagen Stocks Known lesion Rs1GD14790 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rs1HMS00354 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rs1KK102837 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rs1NIG.2173R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)44CE (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)H3C1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)nap16 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2R)Exel6056 (Ryder, 2004.4.26) Df(2R)Exel7095 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14790} NA P{KK102837} NA P{NIG.2173R} NA P{TRiP.HMS00354} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Rs1k09513 No P{lacW}Rs1k09514 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent RNA helicase activity inferred from sequence or structural similarity with Saccharomyces DRS1 (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) RNA helicase activity inferred from sequence or structural similarity with Saccharomyces DRS1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
ribosome biogenesis non-traceable author statement (Spradling et al., 1999)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Rs1 - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - AnxB9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Atg7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Bub1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG10086 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG10131 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG10496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG1091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG10996 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG11655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG12301 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG1234 experimental knowledge based (Guruharsha et al., 2011) Rs1 - CG12818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG13430 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG13567 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG14109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG14253 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG14262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG14507 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG14718 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG15118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG15161 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG15484 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG17029 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG1738 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG2691 experimental knowledge based (Guruharsha et al., 2011) Rs1 - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG31111 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG32137 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG32278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG32344 experimental knowledge based (Guruharsha et al., 2011) Rs1 - CG32812 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG3603 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG3919 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG3995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG42724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG43897 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4415 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4546 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4610 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4709 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4880 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG4951 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG5196 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG5850 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG5886 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG6034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG6073 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG6123 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG6652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG6674 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG6852 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7028 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7137 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7747 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG7818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG8545 experimental knowledge based (Guruharsha et al., 2011) Rs1 - CG8765 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG8801 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Rs1 - CG8939 experimental knowledge based (Guruharsha et al., 2011) Rs1 - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CG9253 experimental knowledge based (Guruharsha et al., 2011) Rs1 - Cdc5 experimental knowledge based (Guruharsha et al., 2011) Rs1 - Chi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - CycB3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Cyt-c-d anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Dbp73D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Dh44-R2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Eap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Fas3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - GABPI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - GstD10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - HDAC6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Hakai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Hcs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Hydr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Incenp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Jon99Ci anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Jra anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Kr-h1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Max anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Moca-cyp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Ns1 experimental knowledge based (Guruharsha et al., 2011) Rs1 - Obp49a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Obp56e anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Oli anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Opbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - PP2A-B' anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Pdf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Pka-C1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Prosα3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Prosβ5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Prp3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Ras64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - RasGAP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Rca1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Rcd5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - RpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Rpn11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Sbp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Sk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Snm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Srp72 experimental knowledge based (Guruharsha et al., 2011) Rs1 - Sse anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Syx1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - TfIIEα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Timp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Trp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Tsp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Ttc19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Ublcp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Ugt86De anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - Vps25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - awd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - boi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - botv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - bsh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - cbx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - dbe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - dome anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - eIF-2α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - eIF-4E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - gcl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - grau anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - grp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - ihog anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - l(1)G0020 experimental knowledge based (Guruharsha et al., 2011) Rs1 - lack anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - lwr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - nclb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - nop5 experimental knowledge based (Guruharsha et al., 2011) Rs1 - pit experimental knowledge based (Guruharsha et al., 2011) Rs1 - row anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - shtd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - sina anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - slmb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - slow anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - su(Hw) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - tor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rs1 - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rs1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68823 DroID - A comprehensive database of gene and protein interactions. • FBgn0021995 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44087
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6549J5 Dipteran inclusive ortholog search EOG6H1B3Z Insect inclusive ortholog search EOG62RC3R Arthropod inclusive ortholog search EOG6DZ09M Metazoa inclusive ortholog search EOG6KQ64C
Orthologs in Drosophila Species (EOG6549J5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rs1     Drosophila simulans   Dsim\GD10546 Y   Drosophila sechellia   Dsec\GM21012 Y   Drosophila erecta   Dere\GG23340 Y   Drosophila yakuba   Dyak\GE19181 Y   Drosophila ananassae   Dana\GF13667 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15282 Y   Drosophila persimilis   Dper\GL11206 Y   Drosophila willistoni   Dwil\GK15774 Y   Drosophila virilis   Dvir\GJ21693 Y   Drosophila mojavensis   Dmoj\GI18677 Y   Drosophila grimshawi   Dgri\GH21077 Y
Orthologs in non-Drosophila Dipterans (EOG6H1B3Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010317   Anopheles gambiae Malaria mosquito  Agam\AGAP011084   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007987
Orthologs in non-Dipteran Insects (EOG62RC3R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40538   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012681   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22579   Atta cephalotes Leafcutter ant  Acep\ACEP11814   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20652   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19654   Linepithema humile Argentine ant  Lhum\LH24192   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15106   Solenopsis invicta Red fire ant  Sinv\SINV21372   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007695   Bombyx mori Silkmoth  Bmor\BGIBMGA014157   Pediculus humanus Human body louse  Phum\PHUM131490   Tribolium castaneum Red flour beetle  Tcas\TC009390
Orthologs in non-Insect Arthropods (EOG6DZ09M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_209410   Ixodes scapularis Deer tick  Isca\ISCW012337
Orthologs in non-Arthropod Metazoa (EOG6KQ64C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y71G12B.8   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017028gn   Danio rerio Zebrafish  Drer\ddx27   Xenopus tropicalis Western clawed frog  Xtro\ddx27   Gallus gallus Domestic chicken  Ggal\DDX27   Mus musculus House mouse  Mmus\Ddx27   Rattus norvegicus Norway rat  Rnor\Ddx27   Homo sapiens Human  Hsap\DDX27
Human Orthologs (1)
Gene OMIM HGNC Hsap\DDX27
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10546 Drosophila sechellia Dsec\GM21012 Drosophila erecta Dere\GG23340 Drosophila yakuba Dyak\GE19181 Drosophila ananassae Dana\GF13667 Drosophila pseudoobscura pseudoobscura Dpse\GA15282 Drosophila persimilis Dper\GL11206 Drosophila willistoni Dwil\GK15774 Drosophila virilis Dvir\GJ21693 Drosophila mojavensis Dmoj\GI18677 Drosophila grimshawi Dgri\GH21077
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10885 y1 w67c23; P{lacW}Rs1k09514/CyO 32363 y1 sc* v1; P{TRiP.HMS00354}attP2/TM3, Sb1
Kyoto	102713 y1 w67c23 ; P{lacW}Rs1k09513 / CyO 111263 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Rs1k09514 /CyO y+
VDRC	v36516 w1118; P{GD14790}v36516
Genomic Clones ( 1 )
	BACR09N11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM05306 LD15481
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02864 GM13826 GM13834 GM25986 LD01243 LD03124 LD07121 LD35403 RE05920 RE05932 RE09192 RE10695 RE14011 RE16331 RE44746 RE51712 RE61751 RE74170 SD22350
Other clones	76851 120832 190136 214213.34 214283.45 CK01.147C.C6 EC052063 EC055086 EC056627 EK120843 EK240923 EK291355 EP11954 EP15560 RE01407
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0021995 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44087
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: BcDNA:GM05306 CG2173 (Heiman, 1999.11)
Source for database merge of	Source for merge of: Rs1 CG2173 (Misra, 2000.8.9)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143713 RefSeq (Proteins) • NP_651970 DDBJ / EMBL / GenBank • AA440636 AA696215 AAD55444 AAF59119 AAO49161 AF181659 AQ025895 AW942361 BT004908 Entrez Gene - A searchable database of RefSeq genes. • 44087 UniProtKB/TrEMBL • Q7JQN4 Q7KK34
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15481
Linkouts
	BioGRID - A database of protein and genetic interactions • 68823 DroID - A comprehensive database of gene and protein interactions. • FBgn0021995 DRSC - Results from RNAi screens. • FBgn0021995 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0021995 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2173-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0021995 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44087 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44087 modMine - Data generated by the modENCODE project. • FBgn0021995
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	153844_at (Kristensen et al., 2005) BcDNA:GM05306   cg2173 (Lasko, 2000) CG2173 (Huang et al., 2005, Andersen and Tapon, 2008, Ni et al., 2010.12.1, Keleman et al., 2009.8.5) DmRH21 (Boudet et al., 2001) Drs1 (Spradling et al., 1999) l(2)k09514 (Beaton, 2000.1.31, BDGP Project Members, 1994-1999, ) Rs1 (Girard et al., 2006, Pawar et al., 2011, Casper and Van Doren, 2009, Chen et al., 2008, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Rs1
Secondary FlyBase IDs
	FBgn0028477
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 1 )
	Pawar et al., 2011, J. Biomol. Screen. 16(4): 436--442 RNAi Screening of Drosophila (Sophophora) melanogaster S2 Cells for Ricin Sensitivity and Resistance. [FBrf0213418] Show all research papers ...