FlyBase Gene Report: Dmel\eIF3h

General Information

Symbol

Dmel\eIF3h

Species

D. melanogaster

Name

eukaryotic translation initiation factor 3 subunit h

Annotation Symbol

CG9124

Feature Type

protein_coding_gene

FlyBase ID

FBgn0022023

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (UniProt, Q9U9Q4)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

eIF-3p40, l(2)k09003, Eukaryotic initiation factor 3 p40 subunit

Key Links

Genomic Location

Cytogenetic map

25C3-25C3

Sequence location

2L:5,051,193..5,053,094 [-]

Recombination map

2-15

RefSeq locus

NT_033779 REGION:5051193..5053094

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables isopeptidase activity

inferred from electronic annotation with InterPro:IPR000555

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables metal-dependent deubiquitinase activity

inferred from sequence or structural similarity with UniProtKB:O15372

(Zhou et al., 2020)

enables metallopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000045368

(assigned by GO_Central )

(Gaudet et al., 2011)

contributes_to translation initiation factor activity

inferred from biological aspect of ancestor with PANTHER:PTN000045506

(assigned by GO_Central )

(Gaudet et al., 2011)

enables translation initiation factor activity

inferred from sequence or structural similarity

(Lasko, 2000)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in positive regulation of Notch signaling pathway

inferred from mutant phenotype

(Zhang et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process

inferred from sequence or structural similarity with UniProtKB:O15372

(Zhou et al., 2020)

involved_in translational initiation

inferred from sequence or structural similarity

(Lasko, 2000)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in cytosol

inferred from sequence or structural similarity

(Lasko, 2000)

part_of eukaryotic 43S preinitiation complex

inferred from biological aspect of ancestor with PANTHER:PTN000045506

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of eukaryotic translation initiation factor 3 complex

inferred from sequence or structural similarity

(Lasko, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000045506

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of polysomal ribosome

inferred from biological aspect of ancestor with PANTHER:PTN000045506

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

JAMM DEUBIQUITINASES

CYTOPLASMIC TRANSLATION INITIATION FACTORS

Pathway (FlyBase)

Positive Regulators of Notch Signaling Pathway

Protein Family (UniProt)

Belongs to the eIF-3 subunit H family. (Q9U9Q4)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

JAMM DEUBIQUITINASES -: The JAMM (JAB1/MPN/MOV34) sub-family of deubiquitinases are Zn[2+]-binding metalloproteases. In general, JAMMs are components of larger assemblies such as the proteasome. JAMM deubiquitinases belong to MEROPS family M67. (Adapted from FBrf0224141).
CYTOPLASMIC TRANSLATION INITIATION FACTORS -: Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).

Pathway (FlyBase)

Positive Regulators of Notch Signaling Pathway -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Protein Function (UniProtKB)

(UniProt, Q9U9Q4)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\eIF3h for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9U9Q4)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

eIF3h-RA

FBtr0079030

NM_080095

1496

338

eIF3h-RB

FBtr0079031

NM_205909

1182

338

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

eIF3h-PA

FBpp0078667

38.4

338

6.01

NP_524834

AAF52210

eIF3h-PB

FBpp0089133

38.4

338

6.01

NP_995631

AAS64639

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

338 aa isoforms: eIF3h-PA, eIF3h-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (PubMed:23716590).

(UniProt, Q9U9Q4)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9U9Q4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF3h using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

eIF-3p40_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eIF3h in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eIF3h

View exonic expression by tissue for Dmel\eIF3h

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0022023

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45682/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0022023

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0022023

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0022023

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9124

Flygut - An atlas of the Drosophila adult midgut

FBgn0022023

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eIF3h

Transgenic constructs containing regulatory region of eIF3h

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)BSC51

(Deal and Cook, 2004.5.27)

Df(2L)BSC110

(Marygold et al., 2007, Deal and Cook, 2005.6.1)

Df(2L)Exel7022

(Marygold et al., 2007, Ryder, 2004.4.26)

Gene not disrupted in

Df(2L)cl-h3

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)tkv2

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

eIF3h^GD14127

lethal, with Scer\GAL4^Mef2.PR

eIF3h^GD14127

lethal, with Scer\GAL4^pnr-MD237

eIF3h^GD14127

lethal | pupal stage, with Scer\GAL4^pnr-MD237

eIF3h^GD14127

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^dpp.PU

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

eIF3h^GD14127

viable, with Scer\GAL4^tin.CΔ4

eIF3h^GD14127

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage

eIF3h^GD14127

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

eIF3h^GD14127

some die during pupal stage, with Scer\GAL4^dpp.PU

visible, with Scer\GAL4^bbg-C96

eIF3h^KK102344

Phenotype manifest in

Allele

embryonic/larval somatic muscle cell, with Scer\GAL4^Mef2.PR

eIF3h^GD14127

ganglion mother cell | larval stage

eIF3h^GD14127

larval neuroblast | larval stage

eIF3h^GD14127

sarcomere, with Scer\GAL4^Mef2.PR

eIF3h^GD14127

wing, with Scer\GAL4^bbg-C96

eIF3h^KK102344

wing margin bristle, with Scer\GAL4^bbg-C96

eIF3h^KK102344

Z disc, with Scer\GAL4^Mef2.PR

eIF3h^GD14127

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\EIF3H

13 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Eif3h

13 of 15

Yes

Rattus norvegicus (Norway rat) (3)

Rnor\LOC100911110

11 of 13

Yes

Rnor\Eif3h

7 of 13

Yes

Rnor\LOC108348062

2 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\eif3h

13 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\eif3hb

14 of 15

Yes

Drer\eif3ha

13 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\eif-3.H

14 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\TIF3H1

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC821.05

10 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EIF3H; eukaryotic translation initiation factor 3 subunit H

13 of 15

603912

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

eIF3h - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

eIF3h - Trc8

pull down, autoradiography

(Lee et al., 2010)

eIF3h - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

eIF3h - aub

affinity technology, tag visualisation by luciferase assay

(Ramat et al., 2020)

eIF3h - eIF3a

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3b

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3c

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3e

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3f1

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3g1

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3k

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3l

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - eIF3m

experimental knowledge based

(Guruharsha et al., 2011)

eIF3h - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

eIF3h - mxt

anti tag coimmunoprecipitation, anti tag western blot

(Hernández et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (PubMed:23716590).

(UniProt, Q9U9Q4 )

Linkouts

BioGRID - A database of protein and genetic interactions.

69808

DroID - A comprehensive database of gene and protein interactions.

FBgn0022023

MIST (protein-protein) - An integrated Molecular Interaction Database

eIF-3p40

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Notch Signaling Pathway -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0022023

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

RNA transport

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-15

Cytogenetic map

25C3-25C3

Sequence location

2L:5,051,193..5,053,094 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25C3-25C3

Limits computationally determined from genome sequence between P{lacW}vkg^k16721&P{lacW}Cg25C^k00405 and P{lacW}l(2)k11206^k11206

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

25C1-25C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

25C1-25C2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-15

(FlyBase, 2016)

2-16.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

10845

y¹ w^67c23; P{lacW}eIF3h^k09003/CyO

55603

y¹ sc^* v¹ sev²¹; P{TRiP.GL01831}attP2

82966

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06644}attP40

Kyoto

112356

w^*; P{GawB}eIF3h^NP0834 / CyO

102701

y¹ w^67c23 ; P{lacW}eIF3h^k09306 / CyO

103021

y¹ w^67c23 ; P{lacW}eIF3h^k16615 / CyO

104898

y^* w^*; P{GawB}eIF3h^NP5205 / CyO, P{UAS-lacZ.UW14}UW14

111254

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}eIF3h^k09003 P{neoFRT}40A/CyO y⁺

VDRC

v106189

P{KK102344}VIE-260B

v36087

w¹¹¹⁸; P{GD14127}v36087

v342180

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01740}attP40/CyO-GFP

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (94)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0022023

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0022023

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

45682

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: BcDNA:GM14618 CG9124

(Kodira, 1999.11)

Source for identity of: eIF3h eIF-3p40

(Marygold et al., 2017)

Source for database merge of

Source for merge of: eIF-3p40 BcDNA:GM14618

(Misra, 2000.8.9)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45682

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9U9Q4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9U9Q4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9U9Q4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0022023

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0022023

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45682/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0022023

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

eIF-3p40_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0022023

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0022023

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9124

Flygut - An atlas of the Drosophila adult midgut

FBgn0022023

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0022023

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

45682

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014327

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9124

MARRVEL_MODEL - MARRVEL (model organism gene)

45682

modMine - A data warehouse for the modENCODE project

FBgn0022023

Linkouts

BioGRID - A database of protein and genetic interactions.

69808

DroID - A comprehensive database of gene and protein interactions.

FBgn0022023

DRSC - Results frm RNAi screens

FBgn0022023

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0022023

FlyMine - An integrated database for Drosophila genomics

FBgn0022023

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

RNA transport

MIST (protein-protein) - An integrated Molecular Interaction Database

eIF-3p40

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BcDNA:GM14618

CG9124

(Vasudevan et al., 2020, Kolkhof et al., 2017, Marygold et al., 2017, Hosono et al., 2015, Shanshan and Laixin, 2015, White-Grindley et al., 2014, Hernández et al., 2013, Zhang et al., 2012, Zhang et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Puri et al., 2008, Lasko, 2000, Whitfield, 2000.5.17)

EIF3H

(Zhou et al., 2020)

Q9U9Q4

(Clague et al., 2013)

eIF-3

(Spradling et al., 1999)

eIF-3p40

(Badmos et al., 2021, Olesnicky et al., 2014, White-Grindley et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Zhang et al., 2012, Friedman et al., 2011, Lee et al., 2010, Puri et al., 2008, Marygold et al., 2007)

eIF3-S3

(Lasko, 2000)

eIF3h

(Jin et al., 2020, Wang et al., 2020, Marygold et al., 2017, Majzoub et al., 2014, Hernández et al., 2013, Yao and Fox, 2011, Lee et al., 2010)

eIF3p40

(Vasudevan et al., 2020)

eIf3-p44

(Jasper et al., 2002)

l(2)k09003

(Beaton, 2000.1.31, BDGP Project Members, 1994-1999)

Name Synonyms

Eukaryotic initiation factor 3 p40 subunit

(Cammarato et al., 2011, Spradling et al., 1999)

eukaryotic translation initiation factor 3 subunit h

Secondary FlyBase IDs