l(2)44Db, ESCRT-II, l(2)k08904
a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body - as part of this complex, Vps25 also has a role in RNA localization
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the endosomal sorting complex required for transport II (ESCRT-II) (By similarity). Interacts with Lsn/Snf8/Vps22 (Probable).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vps25 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Vps25 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Vps25 mosaics disply non-autonomous cell survival and overgrowth, and autonomous apoptosis.