Cas, Dcas, l(2)k03902, CAS/CSE1 segregation protein
signaling protein - functions in axonal fasciculation and pathfinding - functions with integrins to specify axon guidance - functions in nuclear transport in the Notch pathway
Please see the JBrowse view of Dmel\Cse1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Binds with high affinity to importin-alpha only in the presence of RanGTP.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cse1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: low expression in the adult brain cortex
JBrowse - Visual display of RNA-Seq signals
View Dmel\Cse1 in JBrowse2-53
2-51.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Cas is a ubiquitous export receptor that seems to be required in all tissues.
Source for identity of: Cse1 Cas
Renamed from 'Cas' to 'Cse1' in order to minimise confusion with the unrelated 'cas' gene (which only differed by case) and to be consistent with the nomenclature used in other organisms for orthologs of this gene.