FB2020_01, released Feb 12, 2020

Gene: Dmel\Cse1

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General Information
Symbol
Dmel\Cse1
Species
D. melanogaster
Name
Chromosome segregation 1
Annotation Symbol
CG13281
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022213
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As

Cas, Dcas, CAS/CSE1 segregation protein, l(2)k03902

Key Links
Genomic Location
Cytogenetic map
36B1-36B2
Sequence location
2L:16,821,156..16,825,207 [-]
Recombination map

2-53

RefSeq locus
NT_033779 REGION:16821156..16825207
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the XPO2/CSE1 family. (Q9XZU1)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
nuclear export signal receptor activity; Ran GTPase binding
Summaries
Gene Group (FlyBase)
BETA IMPORTINS -
Importin-β family proteins are nucleocytoplasmic transport receptors that import and export proteins and RNAs through the nuclear pores. In some import/export pathways, importin-β directly interacts with the cargo. For cargo containing a classical nuclear localization (cNLS) signal, importin-α acts as an adaptor linking the cargo to importin-β. (Adapted from FBrf0235243, FBrf0131350 and PMID:21029754).
Protein Function (UniProtKB)
Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).
(UniProt, Q9XZU1)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Cse1 or the JBrowse view of Dmel\Cse1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cse1-RA
FBtr0080930
NM_078864
3237
975
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cse1-PA
FBpp0080484
110.1
975
5.50
NP_523588
AAF53575
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Binds with high affinity to importin-alpha only in the presence of RanGTP.

(UniProt, Q9XZU1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cse1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nuclear export signal receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000108304
(assigned by GO_Central )
(Gaudet et al., 2011)
Ran GTPase binding
inferred from electronic annotation with InterPro:IPR001494
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein export from nucleus
inferred from mutant phenotype
(Tekotte et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
protein export from nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000108304
(assigned by GO_Central )
(Gaudet et al., 2011)
protein import into nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
nuclear envelope
inferred from high throughput direct assay
(Lye et al., 2014)
nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(assigned by GO_Central )
(Gaudet et al., 2011)
nuclear envelope
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
nuclear envelope
inferred from high throughput direct assay
(Lye et al., 2014)
nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{602.P.SVS-1}Cse1CPTI000199
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind

Comment: low expression in the adult brain cortex

(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cse1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cse1
Transgenic constructs containing regulatory region of Cse1
Deletions and Duplications ( 4 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CSE1L
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cse1l
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Cse1l
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\cse1l
12 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\cse1l
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\xpo-2
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT2G46520
9 of 9
Yes
Yes
Atha\AT3G17340
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CSE1
14 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\kap109
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901MD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Cse1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000515
Drosophila simulans
Dsim\GD21894
Drosophila sechellia
Dsec\GM17155
Drosophila erecta
Dere\GG20105
Drosophila yakuba
Dyak\GE13161
Drosophila ananassae
Dana\GF14542
Drosophila pseudoobscura pseudoobscura
Dpse\GA12168
Drosophila persimilis
Dper\GL19330
Drosophila willistoni
Dwil\GK18154
Drosophila virilis
Dvir\GJ22118
Drosophila mojavensis
Dmoj\GI17179
Drosophila grimshawi
Dgri\GH13775
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500XZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17026307
Glossina morsitans
Tsetse fly
Gmor\GMOY010038
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07184
Mayetiola destructor
Hessian fly
Mdes\Mdes008402
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008741
Anopheles darlingi
American malaria mosquito
Adar\ADAC006648
Anopheles gambiae
Malaria mosquito
Agam\AGAP010711
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011802
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W018E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004241
Danaus plexippus
Monarch butterfly
Dple\DPOGS203512-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002750
Apis florea
Little honeybee
Aflo\2797666164
Apis mellifera
Western honey bee
Amel\Cas
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24568
Bombus terrestris
Buff-tailed bumblebee
Bter\15212022
Linepithema humile
Argentine ant
Lhum\LH12244
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00073d
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002881
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08860
Tribolium castaneum
Red flour beetle
Tcas\TC015935
Pediculus humanus
Human body louse
Phum\PHUM228000
Rhodnius prolixus
Kissing bug
Rpro\RPRC007018
Rhodnius prolixus
Kissing bug
Rpro\RPRC006914
Cimex lectularius
Bed bug
Clec\CLEC012918
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069408
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003906
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03480
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X016H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009497
Ixodes scapularis
Black-legged tick
Isca\ISCW015464
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61404.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61402.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g01350
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307683
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01TH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005202gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016770gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cas
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017425gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002277
Gallus gallus
Domestic chicken
Ggal\CSE1L
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Impβ11
1 of 10
msk
1 of 10
Ranbp9
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Cse1k03902
    ameliorates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN8OSCTG112.UAS
    (Mutsuddi et al., 2004)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CSE1L; chromosome segregation 1 like
    14 of 15
    601342
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Kap-α1
        enhanceable
        Cse1
        (Ratan et al., 2008)
        Kap-α1
        suppressible
        Cse1
        (Ratan et al., 2008)
        External Data
        Subunit Structure (UniProtKB)
        Binds with high affinity to importin-alpha only in the presence of RanGTP.
        (UniProt, Q9XZU1 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-53

        Cytogenetic map
        36B1-36B2
        Sequence location
        2L:16,821,156..16,825,207 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        36B1-36B2
        Limits computationally determined from genome sequence between P{lacW}Mhck10423&P{lacW}Cask03902 and P{lacW}Aac11k06710
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        36B1-36B2
        (Tekotte, 1999.5.6, BDGP Project Members, 1994-1999)
        36B1-36B2
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        Experimentally Determined Recombination Data
        Location

        2-53

        (FlyBase, 2016)

        2-51.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (13)
        Genomic Clones (15)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (43)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Cse1 Cas

          (FlyBase, 2009-)
          Source for database merge of
          Additional comments

          Renamed from 'Cas' to 'Cse1' in order to minimise confusion with the unrelated 'cas' gene (which only differed by case) and to be consistent with the nomenclature used in other organisms for orthologs of this gene.

          (FlyBase, 2009-)
          Other Comments

          S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

          (Stroschein-Stevenson et al., 2006)

          Cas is a ubiquitous export receptor that seems to be required in all tissues.

          (Tekotte et al., 2002)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 38 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (12)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (80)